DK0462206T3 - Ekspanderede porphyriner: Store porphyrin-lignende tripyrroldimethinafledte makrocykler - Google Patents

Ekspanderede porphyriner: Store porphyrin-lignende tripyrroldimethinafledte makrocykler

Info

Publication number
DK0462206T3
DK0462206T3 DK90905072T DK90905072T DK0462206T3 DK 0462206 T3 DK0462206 T3 DK 0462206T3 DK 90905072 T DK90905072 T DK 90905072T DK 90905072 T DK90905072 T DK 90905072T DK 0462206 T3 DK0462206 T3 DK 0462206T3
Authority
DK
Denmark
Prior art keywords
complexes
texaphyrin
derivatives
porphyrin
macrocycles
Prior art date
Application number
DK90905072T
Other languages
English (en)
Inventor
Jonathan L Sessler
Gregory W Hemmi
Toshiaki Murai
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of DK0462206T3 publication Critical patent/DK0462206T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
DK90905072T 1989-03-06 1990-03-06 Ekspanderede porphyriner: Store porphyrin-lignende tripyrroldimethinafledte makrocykler DK0462206T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/320,293 US4935498A (en) 1989-03-06 1989-03-06 Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
PCT/US1990/001208 WO1990010633A1 (en) 1989-03-06 1990-03-06 Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles

Publications (1)

Publication Number Publication Date
DK0462206T3 true DK0462206T3 (da) 1999-04-26

Family

ID=23245758

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90905072T DK0462206T3 (da) 1989-03-06 1990-03-06 Ekspanderede porphyriner: Store porphyrin-lignende tripyrroldimethinafledte makrocykler

Country Status (10)

Country Link
US (3) US4935498A (da)
EP (1) EP0462206B1 (da)
JP (3) JP3315112B2 (da)
AT (1) ATE169020T1 (da)
AU (1) AU5278190A (da)
CA (1) CA2047699C (da)
DE (1) DE69032525T2 (da)
DK (1) DK0462206T3 (da)
ES (1) ES2119745T3 (da)
WO (1) WO1990010633A1 (da)

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JPH04505612A (ja) 1992-10-01
US4935498A (en) 1990-06-19
DE69032525D1 (de) 1998-09-03
AU5278190A (en) 1990-10-09
CA2047699C (en) 2004-07-13
EP0462206B1 (en) 1998-07-29
DE69032525T2 (de) 1999-04-15
JP2001011077A (ja) 2001-01-16
WO1990010633A1 (en) 1990-09-20
JP3315112B2 (ja) 2002-08-19
EP0462206A1 (en) 1991-12-27
ATE169020T1 (de) 1998-08-15
US5369101A (en) 1994-11-29
CA2047699A1 (en) 1990-09-07
JP2004002438A (ja) 2004-01-08
ES2119745T3 (es) 1998-10-16
US5525325A (en) 1996-06-11

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