DK0457250T3 - Bifunktionelle koblingsforbindelser, konjugater og fremgangsmåder til fremstilling deraf - Google Patents

Bifunktionelle koblingsforbindelser, konjugater og fremgangsmåder til fremstilling deraf

Info

Publication number
DK0457250T3
DK0457250T3 DK91107737T DK91107737T DK0457250T3 DK 0457250 T3 DK0457250 T3 DK 0457250T3 DK 91107737 T DK91107737 T DK 91107737T DK 91107737 T DK91107737 T DK 91107737T DK 0457250 T3 DK0457250 T3 DK 0457250T3
Authority
DK
Denmark
Prior art keywords
conjugates
methods
novel
bifunctional compounds
target
Prior art date
Application number
DK91107737T
Other languages
Danish (da)
English (en)
Inventor
Takushi Kaneko
David Willner
Ivo Monkovic
Robert S Greenfield
Gary R Braslawsky
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK0457250T3 publication Critical patent/DK0457250T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Static Random-Access Memory (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Measurement Of Radiation (AREA)
DK91107737T 1990-05-14 1991-05-13 Bifunktionelle koblingsforbindelser, konjugater og fremgangsmåder til fremstilling deraf DK0457250T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07522996 US5137877B1 (en) 1990-05-14 1990-05-14 Bifunctional linking compounds conjugates and methods for their production

Publications (1)

Publication Number Publication Date
DK0457250T3 true DK0457250T3 (da) 1999-11-29

Family

ID=24083237

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91107737T DK0457250T3 (da) 1990-05-14 1991-05-13 Bifunktionelle koblingsforbindelser, konjugater og fremgangsmåder til fremstilling deraf

Country Status (14)

Country Link
US (2) US5137877B1 (fr)
EP (1) EP0457250B1 (fr)
JP (2) JP3010319B2 (fr)
AT (1) ATE182141T1 (fr)
AU (1) AU646850B2 (fr)
CA (1) CA2042503C (fr)
DE (1) DE69131435T2 (fr)
DK (1) DK0457250T3 (fr)
ES (1) ES2134761T3 (fr)
FI (1) FI100718B (fr)
GR (1) GR3031402T3 (fr)
IE (1) IE911635A1 (fr)
PT (1) PT97639B (fr)
ZA (1) ZA913591B (fr)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622929A (en) * 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
AU3937693A (en) * 1992-04-10 1993-11-18 Brigham And Women's Hospital Methods and compositions for oral delivery of therapeutic agents
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
JPH09502263A (ja) * 1993-08-27 1997-03-04 アボツト・ラボラトリーズ ヒドラジン誘導体化細胞
US5858327A (en) * 1993-09-03 1999-01-12 Resolutions Pharmaceuticals, Inc. Hydrazino-type N2 S2 radionuclide chelating compounds
US5502246A (en) * 1994-03-22 1996-03-26 Eli Lilly And Company Solid-phase synthesis utilizing photochemical carbon-sulfur bond cleavage of thioethers
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US5856571A (en) * 1995-06-07 1999-01-05 Cellpro, Incorporated Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto
WO1997014416A1 (fr) * 1995-10-18 1997-04-24 Merck & Co., Inc. Conjugues utiles pour traiter l'adenome prostatique benin
ES2195036T3 (es) * 1995-12-22 2003-12-01 Bristol Myers Squibb Co Conectores de hidrazona ramificados.
US6177404B1 (en) 1996-10-15 2001-01-23 Merck & Co., Inc. Conjugates useful in the treatment of benign prostatic hyperplasia
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
EP0941120A4 (fr) * 1996-11-05 2004-08-18 Bristol Myers Squibb Co Sequences de liaison peptidiques ramifiees
US6759509B1 (en) 1996-11-05 2004-07-06 Bristol-Myers Squibb Company Branched peptide linkers
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US20030215421A1 (en) * 1999-07-21 2003-11-20 Mcdonald John R. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US6299860B1 (en) * 1998-10-15 2001-10-09 Fluoro Probe, Inc. Method for viewing diseased tissue located within a body cavity
US6652836B2 (en) 1998-10-15 2003-11-25 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6222093B1 (en) * 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US6444657B1 (en) 1998-12-31 2002-09-03 Guilford Pharmaceuticals Inc. Methods for treating certain diseases using naaladase inhibitors
US7192729B2 (en) 1999-07-06 2007-03-20 General Atomics Methods for assaying homocysteine
WO2001062968A2 (fr) * 2000-02-25 2001-08-30 General Atomics Enzymes de liaison nucleique mutantes et leur application dans le diagnostic, la detection et la purification
WO2001071352A2 (fr) * 2000-03-17 2001-09-27 The Salk Institute For Biological Studies Compositions associees a la formation de complexes et leurs procedes d'utilisation
US6610504B1 (en) 2000-04-10 2003-08-26 General Atomics Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase
GB0012718D0 (en) * 2000-05-24 2000-07-19 Angeletti P Ist Richerche Bio Conjugates of aminodrugs
WO2002013873A2 (fr) * 2000-08-17 2002-02-21 Synapse Technologies, Inc. Compositions de composes conjugues a p97 et leurs methodes d'utilisation
WO2002013843A2 (fr) * 2000-08-17 2002-02-21 University Of British Columbia Agents chimiotherapeutiques conjugues avec p97, et leurs utilisations pour le traitement des tumeurs neurologiques
US7445802B2 (en) * 2000-12-26 2008-11-04 Yeda Research And Development Co. Ltd Site-specific in situ generation of allicin using a targeted alliinase delivery system for the treatment of cancers, tumors, infectious diseases and other allicin-sensitive diseases
IL154183A0 (en) 2001-05-31 2003-07-31 Medarex Inc Cytotoxins, prodrugs, linkers and stabilizers useful therefor
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
RU2196604C1 (ru) * 2001-12-21 2003-01-20 Северин Евгений Сергеевич Полипептид, являющийся аналогом рецепторсвязывающего фрагмента эпидермального фактора роста с 21-й по 31-ю аминокислоту, его конъюгат с доксорубицином и фармацевтическая композиция на его основе
US7282590B2 (en) * 2004-02-12 2007-10-16 The Research Foundation Of State University Of New York Drug conjugates
US7384760B2 (en) * 2004-04-30 2008-06-10 General Atomics Methods for assaying inhibitors of S-adenosylhomocysteine (SAH) hydrolase and S-adenosylmethionine (SAM)-dependent methyltransferase
JP4806680B2 (ja) * 2004-05-19 2011-11-02 メダレックス インコーポレイテッド 自己犠牲リンカー及び薬剤複合体
US7691962B2 (en) * 2004-05-19 2010-04-06 Medarex, Inc. Chemical linkers and conjugates thereof
US7541330B2 (en) * 2004-06-15 2009-06-02 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
WO2006012527A1 (fr) * 2004-07-23 2006-02-02 Endocyte, Inc. Groupes de liaison bivalents et conjugués de ceux-ci
AU2006214031A1 (en) * 2005-02-18 2006-08-24 Medarex, Inc. Human monoclonal antibodies to prostate specific membrane antigen (PSMA)
US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
NZ565964A (en) * 2005-08-24 2011-11-25 Immunogen Inc Process for preparing maytansinoid antibody conjugates by purifying with tangential flow filtration
AU2006294554B2 (en) * 2005-09-26 2013-03-21 E. R. Squibb & Sons, L.L.C. Antibody-drug conjugates and methods of use
PL1940789T3 (pl) 2005-10-26 2012-04-30 Squibb & Sons Llc Metody i związki do otrzymywania analogów cc-1065
WO2007059404A2 (fr) 2005-11-10 2007-05-24 Medarex, Inc. Composes et conjugues cytotoxiques
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
CA2678514A1 (fr) * 2007-02-21 2008-08-28 Medarex, Inc. Liants chimiques avec acides amines uniques et conjugues de ceux-ci
CA2688240A1 (fr) 2007-05-24 2008-12-04 The United States Government As Represented By The Department Of Veterans Affairs Transduction de proteines intranucleaires par voie de recuperation des nucleosides
WO2009039207A1 (fr) * 2007-09-19 2009-03-26 Oncofluor, Inc. Procédé d'imagerie et de traitement d'organes et de tissus
AU2015202204A1 (en) * 2008-04-30 2015-05-14 Immunogen, Inc. Cross-linkers and their uses
PL2281006T3 (pl) 2008-04-30 2018-01-31 Immunogen Inc Środki łączące i ich zastosowania
EP2297178B1 (fr) * 2008-05-27 2014-07-30 Genzyme Corporation Analogues peptidiques de l'hormone de stimulation d'alpha-melanocytes
KR101413480B1 (ko) 2008-12-05 2014-07-10 아브락시스 바이오사이언스, 엘엘씨 Ｓｐａｒｃ 결합 펩티드와 이들의 용도
US9155801B2 (en) 2009-05-28 2015-10-13 The United States Government As Represented By The Department Of Veterans Affairs Amino acid sequences which enhance peptide conjugate solubility
SG176068A1 (en) 2009-06-03 2011-12-29 Immunogen Inc Conjugation methods
GB201012410D0 (en) 2010-07-23 2010-09-08 Medical Res Council Intracellular immunity
SI2691155T1 (sl) 2011-03-29 2019-03-29 Immunogen, Inc. Priprava majtanzinoidnih konjugatov protiteles v postopku z enim korakom
EP2592103A1 (fr) 2011-11-08 2013-05-15 Adriacell S.p.A. Dérivés d'aldéhyde de polymère
GB201202268D0 (en) 2012-02-09 2012-03-28 Medical Res Council Intracellular immunity
JP6345181B2 (ja) 2012-10-04 2018-06-20 イムノゲン インコーポレーティッド 細胞結合剤細胞毒性剤コンジュゲートを精製するためのｐｖｄｆ膜の使用
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
CA2906784C (fr) 2013-03-15 2023-02-28 The Centre For Drug Research And Development Composes cytotoxiques et antimitotiques et leurs procedes d'utilisation
WO2015095953A1 (fr) 2013-12-27 2015-07-02 The Centre For Drug Research And Development Systèmes de liaison contenant un sulfonamide pour conjugués de médicaments
MX2016008448A (es) 2013-12-27 2017-01-09 Zymeworks Inc Conjugados de var2csa-farmaco.
WO2015127685A1 (fr) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Lieurs chargés et leurs utilisations pour la conjugaison
KR102494557B1 (ko) 2014-09-17 2023-02-02 자임워크스 비씨 인코포레이티드 세포독성 및 항유사분열성 화합물, 그리고 이를 이용하는 방법
EP3215537B1 (fr) 2014-11-05 2022-01-05 Nanyang Technological University Domaine vh stabilisé et autonome d'un anticorps
CN113350518A (zh) 2015-07-12 2021-09-07 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US9989535B2 (en) * 2015-10-01 2018-06-05 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
US20190330317A1 (en) 2016-06-15 2019-10-31 Yale University Anti-guanosine antibody as a molecular delivery vehicle
US10517958B2 (en) 2016-10-04 2019-12-31 Zymeworks Inc. Compositions and methods for the treatment of platinum-drug resistant cancer
CN116143678A (zh) 2016-11-14 2023-05-23 杭州多禧生物科技有限公司 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
US20210054102A1 (en) 2018-02-01 2021-02-25 Yale University Compositions and methods for enhancing nuclear translocation
WO2022013613A2 (fr) 2020-07-17 2022-01-20 Onena Medicines S.L. Anticorps dirigés contre des protéines lefty
CN113262311B (zh) * 2021-04-29 2022-08-05 武汉纳乐吉生命科技有限公司 肿瘤特异性刺激响应的羟烷基淀粉-阿霉素偶联物、其制备和应用
WO2023010060A2 (fr) 2021-07-27 2023-02-02 Novab, Inc. Anticorps anti-vlrb génétiquement modifiés présentant des fonctions effectrices immunitaires
WO2023056450A1 (fr) 2021-09-30 2023-04-06 Yale University Compositions et méthodes pour le traitement de la polykystose rénale autosomique dominante et d'autres maladies ayant une activité de mtor régulée à la hausse
WO2024050524A1 (fr) 2022-09-01 2024-03-07 University Of Georgia Research Foundation, Inc. Compositions et procédés de direction de l'apolipoprotéine l1 en vue d'induire la mort de cellules de mammifère
WO2024064752A2 (fr) 2022-09-20 2024-03-28 Yale University Compositions d'adhésifs humides dérivés d'adhésines de biofilm vibrio cholerae et procédés associés

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470054A1 (de) * 1963-11-09 1969-05-29 Merck Ag E Schwefelhaltige Pyridin-Derivate und Verfahren zu deren Herstellung
US4130562A (en) * 1975-01-10 1978-12-19 Givaudan Corporation Odorant or flavoring thiazolyl disulphides
SE430062B (sv) * 1977-03-04 1983-10-17 Pharmacia Fine Chemicals Ab Kopplings- eller tioleringsreagens
US4112217A (en) * 1977-09-02 1978-09-05 Sri International Bis-hydrazones of daunomycin and adriamycin
US4250303A (en) * 1977-10-17 1981-02-10 Sri International N-Benzyl anthracyclines
US4258193A (en) * 1978-07-13 1981-03-24 Toyo Jozo Kabushiki Kaisha Disulfide derivatives having S--S exchange reactivity
US4303785A (en) * 1978-08-05 1981-12-01 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antitumor anthracycline antibiotics
US4202967A (en) * 1978-10-02 1980-05-13 Sri International N,N-pentamethylene derivatives of daunomycin and adriamycin
US4282031A (en) * 1979-01-03 1981-08-04 Gulf Oil Corporation Substituted thiosemicarbazides, their manufacture and use as plant growth regulants
US4252962A (en) * 1980-03-24 1981-02-24 Olin Corporation Process for producing 2-amino or selected 2-(substituted)amino-5-mercapto-1,3,4-thiadiazole compounds
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4314054A (en) * 1981-03-23 1982-02-02 Sri International 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin
SE8102193L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och dess anvendning
GB2116979B (en) * 1982-02-25 1985-05-15 Ward Page Faulk Conjugates of proteins with anti-tumour agents
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
ATE25197T1 (de) * 1982-05-12 1987-02-15 Harvard College Hybridproteinekodierende fusionierte gene, sie enthaltende klonierungsvektoren und deren verwendung.
GB2122612B (en) * 1982-06-16 1985-09-25 May & Baker Ltd Cystamine derivatives
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
US4590001A (en) * 1983-03-28 1986-05-20 Stjernholm Rune L Platinum bound to transferrin for use in the treatment of breast tumors
SE8302758L (sv) * 1983-05-17 1984-11-18 Pharmacia Ab Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening
US4545985A (en) * 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
JPS6157579A (ja) * 1984-08-29 1986-03-24 Toyama Chem Co Ltd ３−アミノピロリジンまたはその塩の製造法
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
JPS61274658A (ja) * 1985-05-29 1986-12-04 Morii Shokuhin Kk 半生状はるさめの製造方法
US4797491A (en) * 1986-03-17 1989-01-10 Cetus Corporation Compound 1-(3-(2-pyridyldithio)propionamido)-12-(5-hydrazidoglutaramido)-4,9-dioxadodecane
IN165717B (fr) * 1986-08-07 1989-12-23 Battelle Memorial Institute
US4970303A (en) * 1988-02-03 1990-11-13 Xoma Corporation Linking agents and methods
IL89220A (en) * 1988-02-11 1994-02-27 Bristol Myers Squibb Co Immunoconjugates of anthracycline, their production and pharmaceutical preparations containing them
US5157123A (en) * 1989-03-13 1992-10-20 Georgetown University S-(2-thiopyridyl)-l-cysteine, a heterobifunctional crosslinking reagent

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EP0457250A3 (en) 1992-07-01
US5137877A (en) 1992-08-11
IE911635A1 (en) 1991-11-20
CA2042503C (fr) 2002-07-23
CA2042503A1 (fr) 1991-11-15
PT97639A (pt) 1992-02-28
ES2134761T3 (es) 1999-10-16
EP0457250B1 (fr) 1999-07-14
FI912285A0 (fi) 1991-05-10
FI912285A (fi) 1991-11-15
DE69131435T2 (de) 2000-03-23
PT97639B (pt) 1998-08-31
DE69131435D1 (de) 1999-08-19
JP3010319B2 (ja) 2000-02-21
FI100718B (fi) 1998-02-13
JP3234980B2 (ja) 2001-12-04
EP0457250A2 (fr) 1991-11-21
AU646850B2 (en) 1994-03-10
US5137877B1 (en) 1996-01-30
GR3031402T3 (en) 2000-01-31
ZA913591B (en) 1992-02-26
JP2000026404A (ja) 2000-01-25
ATE182141T1 (de) 1999-07-15
AU7403891A (en) 1991-11-14
US5349066A (en) 1994-09-20
JPH04352765A (ja) 1992-12-07

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