DK0448146T3 - Stabiliserede gonadotropinholdige præparater - Google Patents

Stabiliserede gonadotropinholdige præparater

Info

Publication number
DK0448146T3
DK0448146T3 DK91200483.5T DK91200483T DK0448146T3 DK 0448146 T3 DK0448146 T3 DK 0448146T3 DK 91200483 T DK91200483 T DK 91200483T DK 0448146 T3 DK0448146 T3 DK 0448146T3
Authority
DK
Denmark
Prior art keywords
preparations
lyophilized
dicarboxylic acid
disclosed
acid salt
Prior art date
Application number
DK91200483.5T
Other languages
Danish (da)
English (en)
Inventor
Andreas Leo Johannes De Meere
Marinus Arie De Ruiter
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of DK0448146T3 publication Critical patent/DK0448146T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK91200483.5T 1990-03-20 1991-03-06 Stabiliserede gonadotropinholdige præparater DK0448146T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90200665 1990-03-20

Publications (1)

Publication Number Publication Date
DK0448146T3 true DK0448146T3 (da) 1994-10-24

Family

ID=8204967

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91200483.5T DK0448146T3 (da) 1990-03-20 1991-03-06 Stabiliserede gonadotropinholdige præparater

Country Status (16)

Country Link
EP (1) EP0448146B1 (ko)
JP (1) JP3031570B2 (ko)
KR (1) KR100221123B1 (ko)
AT (1) ATE107172T1 (ko)
AU (1) AU631730B2 (ko)
CA (1) CA2037884C (ko)
DE (1) DE69102465T2 (ko)
DK (1) DK0448146T3 (ko)
ES (1) ES2057731T3 (ko)
FI (1) FI101194B (ko)
HK (1) HK1002494A1 (ko)
ID (1) ID905B (ko)
IE (1) IE64738B1 (ko)
NZ (1) NZ237458A (ko)
PT (1) PT97074B (ko)
ZA (1) ZA911659B (ko)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
DE69401204T2 (de) * 1993-04-28 1997-06-05 Akzo Nobel Nv Gonadotropin enthaltende gefriergetrocknete troepfen
JP4165878B2 (ja) * 1993-06-03 2008-10-15 株式会社林原生物化学研究所 トレハロース遊離酵素とその製造方法並びに用途
US5556771A (en) * 1995-02-10 1996-09-17 Gen-Probe Incorporated Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification
BR9510567A (pt) * 1995-03-21 1998-06-23 Applied Research Systems Formulaçoes líquidas de hcg
IL120202A (en) 1996-03-07 2001-03-19 Akzo Nobel Nv Container with freeze-dried vaccine components
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
WO2000004913A1 (en) * 1998-07-23 2000-02-03 Eli Lilly And Company Fsh and fsh variant formulations, products and methods
JP2002541213A (ja) 1999-04-13 2002-12-03 インヘール セラピューティック システムズ， インコーポレイテッド 不妊症の処置のための乾燥粉末処方物の肺投与
WO2002036145A2 (en) * 2000-10-31 2002-05-10 Pharma Mar, S.A. Kahalalide f formulation
WO2002053136A1 (fr) * 2000-12-28 2002-07-11 Takeda Chemical Industries, Ltd. Preparations a liberation soutenue
GB0207092D0 (en) * 2002-03-26 2002-05-08 Sod Conseils Rech Applic Stable pharmaceutical composition containing factor VIII
AU2004226666B9 (en) * 2003-04-02 2010-04-08 Ares Trading S.A. Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant
US20040248784A1 (en) 2003-06-03 2004-12-09 Marco Filicori Unitary combinations of FSH and hCG
SI1638595T1 (sl) 2003-06-20 2013-04-30 Ares Trading S.A. Liofilizirane formulacije fsh/lh
DE10333317A1 (de) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
SG151298A1 (en) 2004-04-08 2009-04-30 Biomatrica Inc Integration of sample storage and sample management for life science
EP1987067A4 (en) * 2006-02-15 2012-01-25 Imclone Llc ANTIBODY FORMULATION
JP5551601B2 (ja) * 2007-11-01 2014-07-16 メルク セローノ ソシエテ アノニム Ｌｈ液体調製物
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
US8519125B2 (en) 2009-05-11 2013-08-27 Biomatrica, Inc. Compositions and methods for biological sample storage
JP5933544B2 (ja) 2010-07-26 2016-06-08 バイオマトリカ， インコーポレーテッド 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
SG10201509149VA (en) 2010-11-05 2015-12-30 Baxter Int A new variant of antihemophilic factor viii having increased specific activity
CN102293756A (zh) * 2011-08-24 2011-12-28 蚌埠丰原涂山制药有限公司 一种尿促性素冻干粉针剂及其制备方法
AU2012328530A1 (en) 2011-10-28 2014-06-26 Prothena Biosciences Limited Humanized antibodies that recognize alpha-synuclein
EP2807188B1 (en) 2012-01-27 2019-09-11 Prothena Biosciences Limited Humanized antibodies that recognize alpha-synuclein
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
EP2934572A4 (en) 2012-12-20 2016-11-23 Biomatrica Inc FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
US10513555B2 (en) 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods
EP3656215B1 (en) 2014-06-10 2021-08-04 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
AU2016368265B2 (en) 2015-12-08 2021-10-28 Biomatrica, Inc. Reduction of erythrocyte sedimentation rate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932943A (en) * 1970-08-14 1976-01-20 E. I. Du Pont De Nemours And Company Method of preparation of lyophilized biological products
IT1057895B (it) * 1975-02-17 1982-03-30 Serono Lab Gonadotropina corionica umana parzialmente desalinizzata per indurre l'ouvulazione
EP0124018B1 (en) * 1983-04-28 1987-11-25 Armour Pharmaceutical Company Pharmaceutical preparation containing purified fibronectin
GB8604983D0 (en) * 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
US5059587A (en) * 1987-08-03 1991-10-22 Toyo Jozo Company, Ltd. Physiologically active peptide composition for nasal administration

Also Published As

Publication number Publication date
ID905B (id) 1996-09-10
ZA911659B (en) 1991-12-24
NZ237458A (en) 1992-02-25
JP3031570B2 (ja) 2000-04-10
FI101194B1 (fi) 1998-05-15
KR910016340A (ko) 1991-11-05
EP0448146A1 (en) 1991-09-25
AU631730B2 (en) 1992-12-03
FI911309A0 (fi) 1991-03-18
IE64738B1 (en) 1995-09-06
ES2057731T3 (es) 1994-10-16
CA2037884A1 (en) 1991-09-21
DE69102465D1 (de) 1994-07-21
PT97074B (pt) 1998-10-30
ATE107172T1 (de) 1994-07-15
JPH04217630A (ja) 1992-08-07
IE910732A1 (en) 1991-09-25
EP0448146B1 (en) 1994-06-15
KR100221123B1 (ko) 1999-09-15
PT97074A (pt) 1991-10-31
FI101194B (fi) 1998-05-15
DE69102465T2 (de) 1995-03-02
FI911309A (fi) 1991-09-21
AU7362391A (en) 1991-09-26
CA2037884C (en) 2003-10-21
HK1002494A1 (en) 1998-08-28

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