DK0441506T3 - Neurobeskyttende 3-piperidino-4-hydroxychroman-derivater - Google Patents

Neurobeskyttende 3-piperidino-4-hydroxychroman-derivater

Info

Publication number
DK0441506T3
DK0441506T3 DK91300549.2T DK91300549T DK0441506T3 DK 0441506 T3 DK0441506 T3 DK 0441506T3 DK 91300549 T DK91300549 T DK 91300549T DK 0441506 T3 DK0441506 T3 DK 0441506T3
Authority
DK
Denmark
Prior art keywords
piperidino
neuroprotective
hydroxychroman
hydroxychroman derivatives
derivatives
Prior art date
Application number
DK91300549.2T
Other languages
Danish (da)
English (en)
Inventor
Todd William Butler
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0441506T3 publication Critical patent/DK0441506T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/48Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK91300549.2T 1990-02-06 1991-01-24 Neurobeskyttende 3-piperidino-4-hydroxychroman-derivater DK0441506T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/000674 WO1991012005A1 (en) 1990-02-06 1990-02-06 Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs

Publications (1)

Publication Number Publication Date
DK0441506T3 true DK0441506T3 (da) 1994-09-05

Family

ID=22220666

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91300549.2T DK0441506T3 (da) 1990-02-06 1991-01-24 Neurobeskyttende 3-piperidino-4-hydroxychroman-derivater

Country Status (29)

Country Link
US (1) US5356905A (ru)
EP (1) EP0441506B1 (ru)
JP (1) JPH0768214B2 (ru)
KR (1) KR930011041B1 (ru)
CN (1) CN1029960C (ru)
AT (1) ATE108787T1 (ru)
AU (1) AU626490B2 (ru)
BR (1) BR9100490A (ru)
CA (1) CA2035653C (ru)
CZ (1) CZ286218B6 (ru)
DE (2) DE69102893T4 (ru)
DK (1) DK0441506T3 (ru)
EG (1) EG19643A (ru)
ES (1) ES2056571T3 (ru)
FI (1) FI94957C (ru)
HU (1) HU222726B1 (ru)
IE (1) IE63836B1 (ru)
IL (1) IL97100A (ru)
MX (1) MX24433A (ru)
MY (1) MY105293A (ru)
NO (1) NO178399C (ru)
NZ (1) NZ237025A (ru)
PH (1) PH31061A (ru)
PL (1) PL164866B1 (ru)
PT (1) PT96664B (ru)
RU (1) RU2099339C1 (ru)
SK (1) SK281729B6 (ru)
WO (1) WO1991012005A1 (ru)
ZA (1) ZA91830B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018502A1 (en) * 1991-04-18 1992-10-29 Pfizer Inc. Prodrug esters of phenolic 2-piperidino-1-alkanols
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
EP0741724B1 (en) * 1994-01-31 1999-08-11 Pfizer Inc. Neuroprotective chroman compounds
NZ284852A (en) * 1994-08-18 1998-06-26 Pfizer 3-(piperidin-1-yl)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidin-1-yl) alkanol derivatives; medicaments; used as a neuroprotective agent
EP0828513B1 (en) 1995-05-26 2004-01-21 Pfizer Inc. Combinations for the treatment of parkinsonism containing selective nmda antagonists
TW498067B (en) * 1996-07-19 2002-08-11 Hoffmann La Roche 4-hydroxy-piperidine derivatives
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
AU1153601A (en) 1999-10-29 2001-05-08 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole NMDA NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
IL145209A0 (en) 2000-09-06 2002-06-30 Pfizer Prod Inc Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
EA005974B1 (ru) 2001-02-23 2005-08-25 Мерк Энд Ко., Инк. N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
JP2005511478A (ja) 2001-04-03 2005-04-28 メルク エンド カムパニー インコーポレーテッド N−置換非アリール複素環アミジル系nmda/nr2b拮抗薬
WO2005034878A2 (en) * 2003-10-08 2005-04-21 President And Fellows Of Harvard College Pyrovalerone analogs and therapeutic uses thereof
DK1689721T3 (da) * 2003-11-26 2010-09-20 Pfizer Prod Inc Aminopyrazolderivater som GSK-3-ihibitorer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294804A (en) * 1961-01-27 1966-12-27 Sterling Drug Inc 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (ru) * 1966-09-27 1968-01-22
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
US4016281A (en) * 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
DE2507782A1 (de) * 1975-02-22 1976-09-02 Merck Patent Gmbh Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
EP0093534A1 (en) * 1982-04-28 1983-11-09 Beecham Group Plc Novel chromanols
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds

Also Published As

Publication number Publication date
NZ237025A (en) 1992-11-25
IL97100A (en) 1996-06-18
JPH04211058A (ja) 1992-08-03
DE69102893D1 (de) 1994-08-25
CZ286218B6 (cs) 2000-02-16
CA2035653A1 (en) 1991-08-07
IE63836B1 (en) 1995-06-14
ZA91830B (en) 1992-09-30
MY105293A (en) 1994-09-30
RU2099339C1 (ru) 1997-12-20
FI923527A (fi) 1992-08-05
IE910372A1 (en) 1991-08-14
DE69102893T2 (de) 1994-11-03
NO178399B (no) 1995-12-11
EP0441506B1 (en) 1994-07-20
MX24433A (es) 1993-05-01
SK281729B6 (sk) 2001-07-10
NO923081L (no) 1992-08-05
EP0441506A3 (en) 1991-11-21
ES2056571T3 (es) 1994-10-01
KR930011041B1 (ko) 1993-11-20
WO1991012005A1 (en) 1991-08-22
FI94957B (fi) 1995-08-15
JPH0768214B2 (ja) 1995-07-26
PL288949A1 (en) 1991-07-29
BR9100490A (pt) 1991-10-29
AU7029391A (en) 1991-09-05
CS25091A3 (en) 1991-09-15
CA2035653C (en) 1999-12-21
IL97100A0 (en) 1992-03-29
NO178399C (no) 1996-03-20
FI94957C (fi) 1995-11-27
CN1053923A (zh) 1991-08-21
EP0441506A2 (en) 1991-08-14
ATE108787T1 (de) 1994-08-15
PT96664B (pt) 1998-07-31
HU222726B1 (hu) 2003-09-29
EG19643A (en) 1995-09-30
KR910015568A (ko) 1991-09-30
PH31061A (en) 1998-02-05
US5356905A (en) 1994-10-18
DE9101346U1 (ru) 1991-06-06
PT96664A (pt) 1991-10-31
PL164866B1 (pl) 1994-10-31
NO923081D0 (no) 1992-08-05
CN1029960C (zh) 1995-10-11
AU626490B2 (en) 1992-07-30
DE69102893T4 (de) 1995-08-10
FI923527A0 (fi) 1992-08-05

Similar Documents

Publication Publication Date Title
DK0441506T3 (da) Neurobeskyttende 3-piperidino-4-hydroxychroman-derivater
MX9800867A (es) Halogenobencimidazoles y su empleo como microbicidas.
MX9700273A (es) Benzamidinas sustituidas, su preparacion y empleo como sustancias medicamentosas.
DE69637747D1 (de) Zuckerverbindungen
TW332812B (en) A preparing process for phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups
FI933065A0 (fi) Foerfarande foer framstaellning av azabicyklo (2.2.2)oktan-3-iminer och foerfarandet anvaenda mellanprodukter
JPS53137905A (en) Preparation of polyol ether
HUT62581A (en) Process for producing pipeidine derivatives and pharmaceutical compositions comprising such compounds
JPS5319392A (en) Polyamino cyclic polysaccharide compounds and their preparation
CA2055174A1 (en) Process for the synthesis of alpha-((dialkylamino) substituted-methylene)-beta-oxo-(substituted) propanenitriles
JPS52100483A (en) Isoleucomycin a5
JPS546050A (en) Antistatic polyester composition
IT1240644B (it) Derivati polifosfazenici contenenti gruppi azobenzenici atti all&#39; impiego come materiali a caratteristiche fotocromiche
JPS5368790A (en) Preparation of 1-(2&#39;-tetrahydrofuryl)-5-fluorouracil
ES8606368A1 (es) Un procedimiento para producir un derivado de bencil-fosfi- nato etilico
JPS5382795A (en) Novel penicillin derivs., their phermaceutivals and process for theirpreparation
JPS5422353A (en) 2-chloro-2-cyano-7-alkylidene-bicyclo(2,2,1)-5-heptene and its preparation
JPS5368791A (en) Preparation of 1-(2&#39;-tetrahydrofuryl)-5-fluorouracil
JPS5432472A (en) Novel bicyclooctane derivatives
JPS52143287A (en) Mocrobial production of b-methyl-l-norleucine
JPS5436444A (en) Hinge for door
JPS5414738A (en) Paper transporting roller
JPS5239944A (en) Method for constructing a gate-post
JPS52125178A (en) Preparation of n#-(2-tetrahydrofuranyl)-5-fluorouracil
MY124079A (en) Process for producing 1, 2-dimethyl-3-hydroxypyrid-4- one