DK0418071T3 - Nye N-aryl- og N-heteroarylamid- og urinstofderivater som inhibitorer for acyl-coenzym A: cholesterol-acyltransferase - Google Patents
Nye N-aryl- og N-heteroarylamid- og urinstofderivater som inhibitorer for acyl-coenzym A: cholesterol-acyltransferaseInfo
- Publication number
- DK0418071T3 DK0418071T3 DK90310009.7T DK90310009T DK0418071T3 DK 0418071 T3 DK0418071 T3 DK 0418071T3 DK 90310009 T DK90310009 T DK 90310009T DK 0418071 T3 DK0418071 T3 DK 0418071T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- heteroarylamide
- aryl
- cholesterol acyltransferase
- new
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Furan Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1989/004033 WO1991004027A1 (en) | 1989-09-15 | 1989-09-15 | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0418071T3 true DK0418071T3 (da) | 1995-09-04 |
Family
ID=22215232
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94200437T DK0609960T3 (da) | 1989-09-15 | 1990-09-13 | Nye N-heteroarylamidderivater som inhibitorer af acylcoenzym-A: cholesterolacyltransferase |
DK90310009.7T DK0418071T3 (da) | 1989-09-15 | 1990-09-13 | Nye N-aryl- og N-heteroarylamid- og urinstofderivater som inhibitorer for acyl-coenzym A: cholesterol-acyltransferase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94200437T DK0609960T3 (da) | 1989-09-15 | 1990-09-13 | Nye N-heteroarylamidderivater som inhibitorer af acylcoenzym-A: cholesterolacyltransferase |
Country Status (24)
Country | Link |
---|---|
EP (2) | EP0609960B1 (xx) |
JP (1) | JPH0825974B2 (xx) |
KR (1) | KR930011303B1 (xx) |
CN (1) | CN1050183A (xx) |
AT (2) | ATE177082T1 (xx) |
AU (1) | AU652345B2 (xx) |
CA (1) | CA2025301C (xx) |
DD (1) | DD298092A5 (xx) |
DE (2) | DE69032981T2 (xx) |
DK (2) | DK0609960T3 (xx) |
EG (1) | EG19358A (xx) |
ES (2) | ES2071033T3 (xx) |
FI (1) | FI111362B (xx) |
GR (1) | GR3029826T3 (xx) |
HU (1) | HUT70027A (xx) |
IE (1) | IE66324B1 (xx) |
IL (3) | IL95610A (xx) |
MX (1) | MX22406A (xx) |
NO (1) | NO904022L (xx) |
NZ (1) | NZ235323A (xx) |
PL (4) | PL165370B1 (xx) |
PT (1) | PT95310B (xx) |
WO (1) | WO1991004027A1 (xx) |
ZA (1) | ZA907346B (xx) |
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WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
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JPH06500337A (ja) * | 1991-01-31 | 1994-01-13 | ファイザー・インコーポレーテッド | Acat阻害薬の製造における中間体の合成 |
FR2674522B1 (fr) * | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
CA2108014A1 (en) * | 1991-04-26 | 1992-10-27 | Ernest S. Hamanaka | 4-aryl-3-(heteroarylureido)quinoline derivatives |
US5238935A (en) * | 1991-05-20 | 1993-08-24 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
US5124337A (en) * | 1991-05-20 | 1992-06-23 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase |
ES2125325T3 (es) * | 1992-01-23 | 1999-03-01 | Pfizer | Derivados de 4-fenil-3-(heteroarilureido)-1,2-dihidro-2-oxoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos. |
FR2687402B1 (fr) * | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
JPH05320143A (ja) * | 1992-03-18 | 1993-12-03 | Mochida Pharmaceut Co Ltd | 新規ピリミジン誘導体 |
SK142694A3 (en) * | 1992-05-28 | 1995-06-07 | Pfizer | N-aryl and n-heteroarylurea derivatives as inhibitors of acylcoenzyme a:cholesterol-acyltransferase, pharmaceutical preparations contains these compounds and use |
HUT67475A (en) * | 1992-07-20 | 1995-04-28 | Eisai Co Ltd | Benzene derivatives and pharmaceutical compositions containing them as active components |
US5239082A (en) * | 1992-08-03 | 1993-08-24 | Warner-Lambert Company | Sulfonamide tetrazole ACAT inhibitors |
US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
AU2935895A (en) * | 1994-07-15 | 1996-02-16 | Takeda Chemical Industries Ltd. | Tricyclic compounds, their production and use |
US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
WO1996026925A1 (fr) * | 1995-03-01 | 1996-09-06 | Banyu Pharmaceutical Co., Ltd. | Derives de l'arylthioacetamide |
JP4191269B2 (ja) | 1996-05-17 | 2008-12-03 | 興和株式会社 | 新規なアニリド化合物及びこれを含有する医薬 |
EP1028953A1 (en) | 1997-11-03 | 2000-08-23 | Boehringer Ingelheim Pharmaceuticals Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
EP1473292A1 (en) * | 1997-11-03 | 2004-11-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
CA2321237A1 (en) | 1998-02-25 | 1999-09-02 | Masami Muraoka | Pyridone derivatives and process for producing the same |
US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
CA2360934A1 (en) | 1999-02-22 | 2000-08-31 | Lin-Hua Zhang | Polycyclo heterocyclic derivatives as antiinflammatory agents |
CA2361998C (en) | 1999-03-12 | 2009-04-07 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
NZ514711A (en) | 1999-03-12 | 2004-02-27 | Boehringer Ingelheim Pharma | Compounds useful as anti-inflammatory agents |
ATE312823T1 (de) | 1999-07-09 | 2005-12-15 | Boehringer Ingelheim Pharma | Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen |
US6492393B1 (en) | 1999-11-16 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
US6525046B1 (en) | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
GEP20043286B (en) | 2000-02-02 | 2004-07-26 | Warner Lambert Co | Dual Inhibitors of Cholesteryl Ester and Wax Ester Synthesis for Sebaceous Gland Disorders |
US6608052B2 (en) | 2000-02-16 | 2003-08-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
DE10050663A1 (de) † | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
CA2445003A1 (en) | 2001-05-16 | 2002-11-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
WO2002096876A1 (en) | 2001-05-25 | 2002-12-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Carbamate and oxamide compounds as inhibitors of cytokine production |
US7074805B2 (en) * | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
ATE420644T1 (de) * | 2002-02-20 | 2009-01-15 | Abbott Lab | Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1) |
WO2003072569A1 (en) | 2002-02-25 | 2003-09-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
WO2004002481A1 (en) | 2002-06-27 | 2004-01-08 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
US7183411B2 (en) * | 2002-07-12 | 2007-02-27 | Janssen Pharmaceutica N.V. | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor |
US6933311B2 (en) | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
TW200529845A (en) | 2003-12-12 | 2005-09-16 | Wyeth Corp | Quinolines useful in treating cardiovascular disease |
EP1723128B1 (en) | 2004-01-06 | 2012-11-07 | Novo Nordisk A/S | Heteroaryl-ureas and their use as glucokinase activators |
CA2565812C (en) | 2004-05-06 | 2012-03-13 | Warner-Lambert Company Llc | 4-phenylamino-quinazolin-6-yl-amides |
EP1767527A4 (en) | 2004-06-30 | 2009-11-11 | Kowa Co | PROCESS FOR PRODUCING CYCLIC DIAMINE DERIVATIVE |
ATE547396T1 (de) | 2005-07-08 | 2012-03-15 | Novo Nordisk As | Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren |
AU2006268708A1 (en) | 2005-07-08 | 2007-01-18 | Transtech Pharma Inc. | Dicycloalkyl urea glucokinase activators |
AU2006268589B2 (en) | 2005-07-14 | 2011-09-29 | Vtv Therapeutics Llc | Urea glucokinase activators |
ES2341489T3 (es) | 2005-07-27 | 2010-06-21 | F.Hoffmann-La Roche Ag | Derivados de 4-ariloxi quinolina como moduladores de 5-ht6. |
US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
WO2008024945A1 (en) | 2006-08-25 | 2008-02-28 | Abbott Laboratories | Indazole derivatives that inhibit trpv1 and uses thereof |
WO2008039645A1 (en) * | 2006-09-25 | 2008-04-03 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
CA2672196A1 (en) | 2006-12-20 | 2008-07-03 | Abbott Laboratories | Antagonists of the trpv1 receptor and uses thereof |
US8138185B2 (en) | 2007-01-09 | 2012-03-20 | Novo Nordisk A/S | Urea glucokinase activators |
CA2675111C (en) | 2007-01-11 | 2016-04-05 | Novo Nordisk A\S | Urea glucokinase activators |
WO2009117626A2 (en) | 2008-03-20 | 2009-09-24 | Abbott Laboratories | Methods for making central nervous system agents that are trpv1 antagonists |
MX2012006615A (es) | 2009-12-11 | 2012-10-05 | Autifony Therapeuticts Ltd | Derivados de imidazolidinodiona. |
KR101862375B1 (ko) | 2010-12-06 | 2018-05-29 | 오티포니 세라피틱스 리미티드 | Kv3 억제제로서 유용한 하이단토인 유도체 |
BR112013031402A2 (pt) | 2011-06-07 | 2017-06-27 | Autifony Therapeutics Ltd | derivados de hidantoína como inibidores de kv3 |
BR112014028718A2 (pt) | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | derivados de hidantoína como inibidores de kv3 |
JP6240667B2 (ja) | 2012-05-22 | 2017-11-29 | アウトイフオンイ トヘラペウトイクス リミテッド | Kv3阻害剤としてのトリアゾール |
AU2019287437A1 (en) | 2018-06-12 | 2020-09-10 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
CN109553591B (zh) * | 2019-01-15 | 2020-12-15 | 山东安信制药有限公司 | 一种富马酸喹硫平中间体的制备方法 |
GB201919213D0 (en) * | 2019-12-23 | 2020-02-05 | Ucb Biopharma Sprl | Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds |
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NL125255C (xx) * | 1964-07-31 | |||
CH491112A (de) * | 1966-01-28 | 1970-05-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren |
CH500980A (de) * | 1966-01-28 | 1970-12-31 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Amiden aliphatischer Carbonsäuren |
US3555035A (en) * | 1966-01-28 | 1971-01-12 | Geigy Chem Corp | N-(substituted pyridyl) linolamides and -linolenamides |
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US4722927A (en) * | 1986-04-28 | 1988-02-02 | Warner-Lambert Company | Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase |
US4716175A (en) * | 1987-02-24 | 1987-12-29 | Warner-Lambert Company | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
US5238908A (en) * | 1989-08-31 | 1993-08-24 | Rohm And Haas Company | Herbicidal glutaramic acids and derivatives |
DE3929507A1 (de) * | 1989-09-06 | 1991-03-07 | Bayer Ag | Substituierte amino-pyridine |
WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
-
1989
- 1989-09-15 WO PCT/US1989/004033 patent/WO1991004027A1/en unknown
- 1989-09-15 MX MX2240690A patent/MX22406A/es unknown
-
1990
- 1990-09-07 IL IL9561090A patent/IL95610A/en not_active IP Right Cessation
- 1990-09-13 DE DE69032981T patent/DE69032981T2/de not_active Expired - Fee Related
- 1990-09-13 DE DE69018908T patent/DE69018908T2/de not_active Expired - Fee Related
- 1990-09-13 DK DK94200437T patent/DK0609960T3/da active
- 1990-09-13 EP EP94200437A patent/EP0609960B1/en not_active Expired - Lifetime
- 1990-09-13 AT AT94200437T patent/ATE177082T1/de not_active IP Right Cessation
- 1990-09-13 EP EP90310009A patent/EP0418071B1/en not_active Expired - Lifetime
- 1990-09-13 PT PT95310A patent/PT95310B/pt not_active IP Right Cessation
- 1990-09-13 CA CA002025301A patent/CA2025301C/en not_active Expired - Fee Related
- 1990-09-13 DK DK90310009.7T patent/DK0418071T3/da active
- 1990-09-13 EG EG54590A patent/EG19358A/xx active
- 1990-09-13 ES ES90310009T patent/ES2071033T3/es not_active Expired - Lifetime
- 1990-09-13 AT AT90310009T patent/ATE121730T1/de not_active IP Right Cessation
- 1990-09-13 ES ES94200437T patent/ES2127878T3/es not_active Expired - Lifetime
- 1990-09-14 NO NO90904022A patent/NO904022L/no unknown
- 1990-09-14 HU HU9302945A patent/HUT70027A/hu unknown
- 1990-09-14 PL PL90286899A patent/PL165370B1/pl unknown
- 1990-09-14 AU AU62553/90A patent/AU652345B2/en not_active Ceased
- 1990-09-14 ZA ZA907346A patent/ZA907346B/xx unknown
- 1990-09-14 JP JP2245969A patent/JPH0825974B2/ja not_active Expired - Fee Related
- 1990-09-14 PL PL29147290A patent/PL291472A1/xx unknown
- 1990-09-14 PL PL90291470A patent/PL165357B1/pl unknown
- 1990-09-14 KR KR1019900014554A patent/KR930011303B1/ko not_active IP Right Cessation
- 1990-09-14 FI FI904537A patent/FI111362B/fi active IP Right Grant
- 1990-09-14 IE IE333690A patent/IE66324B1/en not_active IP Right Cessation
- 1990-09-14 CN CN90108294A patent/CN1050183A/zh active Pending
- 1990-09-14 PL PL29147190A patent/PL291471A1/xx unknown
- 1990-09-14 NZ NZ235323A patent/NZ235323A/xx unknown
- 1990-09-27 DD DD90343971A patent/DD298092A5/de not_active IP Right Cessation
-
1994
- 1994-07-14 IL IL11032194A patent/IL110321A0/xx unknown
- 1994-07-14 IL IL11032494A patent/IL110324A0/xx unknown
-
1999
- 1999-03-30 GR GR990400917T patent/GR3029826T3/el unknown
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