DK0384349T3 - Substituerede pyrroler - Google Patents

Substituerede pyrroler

Info

Publication number
DK0384349T3
DK0384349T3 DK90103142.7T DK90103142T DK0384349T3 DK 0384349 T3 DK0384349 T3 DK 0384349T3 DK 90103142 T DK90103142 T DK 90103142T DK 0384349 T3 DK0384349 T3 DK 0384349T3
Authority
DK
Denmark
Prior art keywords
active substances
derivatives
substances
pyrrols
substituted
Prior art date
Application number
DK90103142.7T
Other languages
Danish (da)
English (en)
Inventor
Peter David Davis
Christopher Huw Hill
Geoffrey Lawton
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898904161A external-priority patent/GB8904161D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0384349T3 publication Critical patent/DK0384349T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
DK90103142.7T 1989-02-23 1990-02-19 Substituerede pyrroler DK0384349T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898904161A GB8904161D0 (en) 1989-02-23 1989-02-23 Substituted pyrroles
GB898928210A GB8928210D0 (en) 1989-02-23 1989-12-13 Substituted pyrroles

Publications (1)

Publication Number Publication Date
DK0384349T3 true DK0384349T3 (da) 1994-09-05

Family

ID=26295005

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90103142.7T DK0384349T3 (da) 1989-02-23 1990-02-19 Substituerede pyrroler

Country Status (20)

Country Link
EP (1) EP0384349B1 (fr)
JP (1) JPH06102661B2 (fr)
AT (1) ATE104972T1 (fr)
AU (1) AU633051B2 (fr)
CA (1) CA2010636C (fr)
CZ (1) CZ284587B6 (fr)
DE (1) DE59005491D1 (fr)
DK (1) DK0384349T3 (fr)
DZ (1) DZ1399A1 (fr)
ES (1) ES2052995T3 (fr)
FI (1) FI93447C (fr)
HU (1) HU206351B (fr)
IE (1) IE64184B1 (fr)
IL (1) IL93433A (fr)
MC (1) MC2096A1 (fr)
NO (1) NO174891C (fr)
NZ (1) NZ232589A (fr)
PT (1) PT93246B (fr)
RU (2) RU2014332C1 (fr)
SK (1) SK85590A3 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2046801C (fr) * 1990-08-07 2002-02-26 Peter D. Davis Pyrroles substitues
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
EP0630241A1 (fr) * 1992-03-20 1994-12-28 The Wellcome Foundation Limited Derives d'indole presentant une action antivirale
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
JPH07238044A (ja) * 1993-12-07 1995-09-12 Eli Lilly & Co ビスインドリルマレイミドの改良合成法
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
YU49200B (sh) * 1993-12-07 2004-09-03 Eli Lilly And Company Inhibitori proteinske kinaze c
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
PT817627E (pt) * 1993-12-23 2005-07-29 Lilly Co Eli Inibidores da proteina cinase c
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
DK0695755T3 (da) * 1994-08-04 1999-06-28 Hoffmann La Roche Pyrrolocarbazoler
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
EP0797575B1 (fr) * 1994-12-13 2003-10-15 F. Hoffmann-La Roche Ag Derives imidazoles utilises comme inhibiteurs de la proteine kinase, notamment de la tyrosine kinase du recepteur du facteur de croissance de l'epiderme (egf-r)
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
ES2212814T3 (es) * 1996-10-31 2004-08-01 Harbor Branch Oceanographic Institution, Inc. Uso de compuestos y composiciones antiinflamatorias neurogenicas.
EP1224932A4 (fr) * 1999-08-20 2002-10-16 Sagami Chem Res Medicaments inhibant la mort cellulaire
WO2002010158A2 (fr) 2000-07-27 2002-02-07 F. Hoffmann-La Roche Ag Derives de 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione agissant comme inhibiteurs de la glycogene synthase kinase-3beta
CA2431166A1 (fr) 2000-12-08 2002-06-13 Ortho-Mcneil Pharmaceutical, Inc. Composes de pyrroline substitues par l'indazolyle comme inhibiteurs de kinase
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
JP2007501774A (ja) 2003-08-08 2007-02-01 ノバルティス アクチエンゲゼルシャフト スタウロスポリンを含む組み合わせ
RU2373201C2 (ru) * 2004-01-19 2009-11-20 Новартис Аг Индолилмалеимидные производные
WO2006061212A1 (fr) 2004-12-08 2006-06-15 Johannes Gutenberg-Universität Mainz Derives de 3-(indolyl)-4-arylmaleimide et utilisation comme inhibiteurs de l'angiogenese
PL1846406T3 (pl) 2005-02-09 2011-04-29 Arqule Inc Pochodne imidowe kwasu maleinowego, kompozycje farmaceutyczne i sposoby leczenia nowotworów
RU2008104510A (ru) 2005-07-11 2009-08-20 Новартис АГ (CH) Производные индолилмалеинимида
US7696222B2 (en) * 2005-08-12 2010-04-13 Merck Frosst Canada Ltd Indole derivatives as CRTH2 receptor antagonists
EP1980561B1 (fr) 2007-03-30 2013-10-09 Nerviano Medical Sciences S.R.L. Dérivés de pyridines 1h-pyrazolo[3,4-b] substitués actifs en tant qu'inhibiteurs de kinase
BRPI0813355A2 (pt) 2007-06-22 2014-12-30 Arqule Inc Compostos de quinazolinona e métodos de uso dos mesmos
JP5490688B2 (ja) 2007-06-22 2014-05-14 アークル インコーポレイテッド 癌の治療のためのインドリルピロリジン
CN101801961B (zh) * 2007-06-22 2014-09-24 艾科尔公司 吡咯烷酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺衍生物、组合物以及治疗癌症的方法
CA2737483A1 (fr) * 2008-09-22 2010-03-25 Merck Frosst Canada Ltd. Derives d'indole comme antagonistes du recepteur crth2
EP2343291A1 (fr) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz Composés de 3-(indolyl)- ou 3-(azaindolyl)-4-arylmaléimide et leur utilisation dans le traitement de tumeurs
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds
EP2474541A1 (fr) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Composés conjugués de 3-(indolyl)- et 3-(azaindolyl)-4-arylmaléimide et leur utilisation dans le traitement de tumeurs
MX2015014907A (es) * 2013-04-23 2016-03-07 Esteve Labor Dr Compuestos de pirazino - [1,2-a] indol, su preparacion y su uso en medicamentos.
EP3741375A1 (fr) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de traitement de maladies associées aux jonctions neuromusculaires
WO2016207366A1 (fr) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques de traitement d'infections virales
EP3187495A1 (fr) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz Composés de 3-(5-fluoroindolyl)-4-arylmaléimide et leur utilisation dans le traitement de tumeurs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
EP0350129A1 (fr) * 1988-07-07 1990-01-10 Duphar International Research B.V Indole cétones annelées avec un substituant imidazolylalkyle

Also Published As

Publication number Publication date
CZ85590A3 (cs) 1998-10-14
RU2014332C1 (ru) 1994-06-15
NO174891C (no) 1994-07-27
HU206351B (en) 1992-10-28
SK278711B6 (sk) 1998-01-14
IL93433A0 (en) 1990-11-29
ATE104972T1 (de) 1994-05-15
MC2096A1 (fr) 1991-02-15
AU5003390A (en) 1990-08-30
PT93246B (pt) 1996-01-31
CA2010636C (fr) 1999-12-14
HUT53369A (en) 1990-10-28
NO900855L (no) 1990-08-24
IL93433A (en) 1996-11-14
IE900647L (en) 1990-08-23
JPH06102661B2 (ja) 1994-12-14
NO900855D0 (no) 1990-02-22
HU900846D0 (en) 1990-04-28
ES2052995T3 (es) 1994-07-16
NZ232589A (en) 1992-09-25
SK85590A3 (en) 1998-01-14
PT93246A (pt) 1990-08-31
DE59005491D1 (de) 1994-06-01
EP0384349B1 (fr) 1994-04-27
NO174891B (no) 1994-04-18
IE64184B1 (en) 1995-07-12
FI93447C (fi) 1995-04-10
DZ1399A1 (fr) 2004-09-13
FI93447B (fi) 1994-12-30
RU2142460C1 (ru) 1999-12-10
JPH02264776A (ja) 1990-10-29
CZ284587B6 (cs) 1999-01-13
FI900863A0 (fi) 1990-02-21
CA2010636A1 (fr) 1990-08-23
EP0384349A1 (fr) 1990-08-29
AU633051B2 (en) 1993-01-21

Similar Documents

Publication Publication Date Title
DK0384349T3 (da) Substituerede pyrroler
FI96204C (fi) Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten yhdisteiden valmistamiseksi
CA2107105A1 (fr) Derives d'amine heterocycliques-cycliques
RU93033479A (ru) Способ получения замещенных пирролов, способ получения фармацевтических препаратов
DE122005000012I2 (de) N-(Pyrrolo(2-3-d)pyrimidin-3-ylacyl-Glutamins{urederivate
DE3880047T2 (de) Zusammensetzung eines zusatzes.
NO905608D0 (no) Fremgangsmaate for fremstilling av a-nor-steroid-3-karboksylsyrederivater.
FR2722210B1 (fr) Nouvelles streptogramines et procede de preparation de streptogramines par mutasynthese
NO995431D0 (no) Substituerte 3,3-diamino-2-propennitriler, deres fremstilling og anvendelse
NO905288L (no) Fremgangsmaate for aa oeke den spesifikke vekt av roedslam-faststoff.
DK0696278T3 (da) Herbicidtvirkende substituerede 1-phenyl- eller 1-pyridinylbenzotriazoler
ATE92469T1 (de) Neue alpha-aminocarbonsaeure-derivate, ihre herstellung und verwendung.
ATE92070T1 (de) Azachromanderivate.
FI906162A0 (fi) Foerfarande foer framstaellning av 3-(n-metyl-n-alkyl)-amino-2-metoximetylenpropan-1-olderivat.
DK0418990T3 (da) 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
KR910010503U (ko) 수차용 틀체장치
NO905569D0 (no) Fremgangsmaate for fremstilling av fettsyrehalogenider.
NO931072D0 (no) Fremgangsmaate for fremstilling av polyhydraksyfettsyreamider i naervaer av loesningsmiddler