AU5003390A - Substituted pyrroles - Google Patents
Substituted pyrrolesInfo
- Publication number
- AU5003390A AU5003390A AU50033/90A AU5003390A AU5003390A AU 5003390 A AU5003390 A AU 5003390A AU 50033/90 A AU50033/90 A AU 50033/90A AU 5003390 A AU5003390 A AU 5003390A AU 5003390 A AU5003390 A AU 5003390A
- Authority
- AU
- Australia
- Prior art keywords
- substituted pyrroles
- active substances
- derivatives
- substances
- furandione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Pyridine Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
The pyrrole derivatives of the formula <IMAGE> in which R<1> to R<8>, R, X, Y and m have the meaning given in the description, are therapeutically active substances, in particular for use as substances having antiinflammatory, immunological, oncological, bronchopulmonary and cardiovascular activity or as active substances in the treatment of asthma or AIDS. They are prepared from corresponding furandione derivatives in which X and Y stand for =N-R or O.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8904161 | 1989-02-23 | ||
GB898904161A GB8904161D0 (en) | 1989-02-23 | 1989-02-23 | Substituted pyrroles |
GB898928210A GB8928210D0 (en) | 1989-02-23 | 1989-12-13 | Substituted pyrroles |
GB8928210 | 1989-12-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5003390A true AU5003390A (en) | 1990-08-30 |
AU633051B2 AU633051B2 (en) | 1993-01-21 |
Family
ID=26295005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU50033/90A Ceased AU633051B2 (en) | 1989-02-23 | 1990-02-21 | Substituted pyrroles |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0384349B1 (en) |
JP (1) | JPH06102661B2 (en) |
AT (1) | ATE104972T1 (en) |
AU (1) | AU633051B2 (en) |
CA (1) | CA2010636C (en) |
CZ (1) | CZ284587B6 (en) |
DE (1) | DE59005491D1 (en) |
DK (1) | DK0384349T3 (en) |
DZ (1) | DZ1399A1 (en) |
ES (1) | ES2052995T3 (en) |
FI (1) | FI93447C (en) |
HU (1) | HU206351B (en) |
IE (1) | IE64184B1 (en) |
IL (1) | IL93433A (en) |
MC (1) | MC2096A1 (en) |
NO (1) | NO174891C (en) |
NZ (1) | NZ232589A (en) |
PT (1) | PT93246B (en) |
RU (2) | RU2014332C1 (en) |
SK (1) | SK278711B6 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU649699B2 (en) * | 1990-08-07 | 1994-06-02 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
DE4128015A1 (en) * | 1991-08-23 | 1993-02-25 | Kali Chemie Pharma Gmbh | 1,7-ANELLIZED 2- (PIPERAZINOALKYL) INDOL DERIVATIVES AND METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SUCH COMPOUNDS |
GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
WO1993018765A1 (en) * | 1992-03-20 | 1993-09-30 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
US5721230A (en) * | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
RU2147304C1 (en) * | 1993-12-07 | 2000-04-10 | Эли Лилли Энд Компани | Macrocyclic bis-indol maleimide derivatives, method of preparation thereof (variants) and pharmaceutical composition |
US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
HUT69164A (en) * | 1993-12-07 | 1995-08-28 | Lilly Co Eli | Improved process for producing bis-indolyl-maleimide derivatives |
EP1449529B1 (en) * | 1993-12-23 | 2010-01-27 | Eli Lilly And Company | Protein Kinase C Inhibitors |
US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
DK0695755T3 (en) * | 1994-08-04 | 1999-06-28 | Hoffmann La Roche | pyrrolocarbazoles |
US5475110A (en) * | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
US5591855A (en) * | 1994-10-14 | 1997-01-07 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5594009A (en) * | 1994-10-14 | 1997-01-14 | Cephalon, Inc. | Fused pyrrolocarbazoles |
ATE252094T1 (en) * | 1994-12-13 | 2003-11-15 | Hoffmann La Roche | IMIDAZOLE DERIVATIVES WITH PROTEIN KINASE, IN PARTICULAR EGF-R TYROSINE KINASE, AN INHIBITING EFFECT |
US5616724A (en) * | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
ES2212814T3 (en) * | 1996-10-31 | 2004-08-01 | Harbor Branch Oceanographic Institution, Inc. | USE OF NEUROGENIC ANTI-INFLAMMATORY COMPOUNDS AND COMPOSITIONS. |
EP1224932A4 (en) * | 1999-08-20 | 2002-10-16 | Sagami Chem Res | Drugs inhibiting cell death |
HUP0301431A2 (en) | 2000-07-27 | 2003-08-28 | F. Hoffmann-La Roche Ag. | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivativas as inhibitors of glycogen synthase kinase-3betha, process for their preparation and pharmaceutical compositions containing them |
ES2263681T3 (en) | 2000-12-08 | 2006-12-16 | Ortho-Mcneil Pharmaceutical, Inc. | INDAZOLIL-SUBSTITUTED PIRROLINE COMPOUNDS AS INHIBITORS OF THE KINASA. |
TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
CN100536850C (en) | 2003-08-08 | 2009-09-09 | 诺瓦提斯公司 | Combinations comprising staurosporines |
PT1709030E (en) * | 2004-01-19 | 2008-07-01 | Novartis Ag | Indolylmaleimide derivatives |
US8008320B2 (en) | 2004-12-08 | 2011-08-30 | Johannes Gutenberg-Universitatis | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
RU2409579C2 (en) | 2005-02-09 | 2011-01-20 | Аркьюл, Инк. | Compositions and methods of treating cancer |
RU2008104510A (en) * | 2005-07-11 | 2009-08-20 | Новартис АГ (CH) | INDOLYLMALEINIMIDE DERIVATIVES |
EP1915372B1 (en) * | 2005-08-12 | 2013-11-20 | Merck Canada Inc. | Indole derivatives as crth2 receptor antagonists |
EP1980561B1 (en) | 2007-03-30 | 2013-10-09 | Nerviano Medical Sciences S.R.L. | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors |
EP2173748B1 (en) | 2007-06-22 | 2011-08-31 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
JP5425060B2 (en) * | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for the treatment of cancer |
EP2173724B1 (en) | 2007-06-22 | 2012-12-05 | ArQule, Inc. | Quinazolinone compounds and methods of use thereof |
US8637671B2 (en) | 2008-09-22 | 2014-01-28 | Merck Canada Inc. | Indole derivatives as CRTH2 receptor antagonists |
EP2343291A1 (en) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
WO2011082266A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted heterocyclic compounds |
EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
BR112015026908A2 (en) * | 2013-04-23 | 2017-07-25 | Esteve Labor Dr | pyrazine [1,2-a] indole compounds, their preparation and use in pharmaceuticals |
EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
US5049563A (en) * | 1988-07-07 | 1991-09-17 | Duphar International Research B.V. | Annelated indoleketones with an imidazolylalkyl substituent |
-
1990
- 1990-02-16 MC MC902110A patent/MC2096A1/en unknown
- 1990-02-19 DE DE59005491T patent/DE59005491D1/en not_active Expired - Fee Related
- 1990-02-19 AT AT9090103142T patent/ATE104972T1/en not_active IP Right Cessation
- 1990-02-19 HU HU90846A patent/HU206351B/en not_active IP Right Cessation
- 1990-02-19 DK DK90103142.7T patent/DK0384349T3/en active
- 1990-02-19 NZ NZ232589A patent/NZ232589A/en unknown
- 1990-02-19 EP EP90103142A patent/EP0384349B1/en not_active Expired - Lifetime
- 1990-02-19 ES ES90103142T patent/ES2052995T3/en not_active Expired - Lifetime
- 1990-02-19 IL IL9343390A patent/IL93433A/en not_active IP Right Cessation
- 1990-02-21 AU AU50033/90A patent/AU633051B2/en not_active Ceased
- 1990-02-21 DZ DZ900033A patent/DZ1399A1/en active
- 1990-02-21 FI FI900863A patent/FI93447C/en not_active IP Right Cessation
- 1990-02-22 RU SU904743198A patent/RU2014332C1/en active
- 1990-02-22 CA CA002010636A patent/CA2010636C/en not_active Expired - Fee Related
- 1990-02-22 CZ CS90855A patent/CZ284587B6/en not_active IP Right Cessation
- 1990-02-22 IE IE64790A patent/IE64184B1/en not_active IP Right Cessation
- 1990-02-22 PT PT93246A patent/PT93246B/en not_active IP Right Cessation
- 1990-02-22 JP JP2042286A patent/JPH06102661B2/en not_active Expired - Fee Related
- 1990-02-22 NO NO900855A patent/NO174891C/en unknown
- 1990-02-22 SK SK855-90A patent/SK278711B6/en unknown
- 1990-02-22 RU RU93033479A patent/RU2142460C1/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU649699B2 (en) * | 1990-08-07 | 1994-06-02 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
Also Published As
Publication number | Publication date |
---|---|
NZ232589A (en) | 1992-09-25 |
EP0384349B1 (en) | 1994-04-27 |
HU206351B (en) | 1992-10-28 |
DE59005491D1 (en) | 1994-06-01 |
NO174891B (en) | 1994-04-18 |
SK85590A3 (en) | 1998-01-14 |
DK0384349T3 (en) | 1994-09-05 |
CZ284587B6 (en) | 1999-01-13 |
HU900846D0 (en) | 1990-04-28 |
IL93433A (en) | 1996-11-14 |
IE64184B1 (en) | 1995-07-12 |
IE900647L (en) | 1990-08-23 |
MC2096A1 (en) | 1991-02-15 |
CA2010636A1 (en) | 1990-08-23 |
FI93447B (en) | 1994-12-30 |
CA2010636C (en) | 1999-12-14 |
ATE104972T1 (en) | 1994-05-15 |
DZ1399A1 (en) | 2004-09-13 |
JPH02264776A (en) | 1990-10-29 |
PT93246B (en) | 1996-01-31 |
JPH06102661B2 (en) | 1994-12-14 |
EP0384349A1 (en) | 1990-08-29 |
ES2052995T3 (en) | 1994-07-16 |
NO900855D0 (en) | 1990-02-22 |
IL93433A0 (en) | 1990-11-29 |
PT93246A (en) | 1990-08-31 |
RU2142460C1 (en) | 1999-12-10 |
NO900855L (en) | 1990-08-24 |
FI900863A0 (en) | 1990-02-21 |
RU2014332C1 (en) | 1994-06-15 |
HUT53369A (en) | 1990-10-28 |
SK278711B6 (en) | 1998-01-14 |
NO174891C (en) | 1994-07-27 |
FI93447C (en) | 1995-04-10 |
AU633051B2 (en) | 1993-01-21 |
CZ85590A3 (en) | 1998-10-14 |
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