AU5003390A - Substituted pyrroles - Google Patents

Substituted pyrroles

Info

Publication number
AU5003390A
AU5003390A AU50033/90A AU5003390A AU5003390A AU 5003390 A AU5003390 A AU 5003390A AU 50033/90 A AU50033/90 A AU 50033/90A AU 5003390 A AU5003390 A AU 5003390A AU 5003390 A AU5003390 A AU 5003390A
Authority
AU
Australia
Prior art keywords
substituted pyrroles
pyrroles
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU50033/90A
Other versions
AU633051B2 (en
Inventor
Peter David Davis
Christopher Huw Hill
Geoffrey Lawton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB898904161A priority Critical patent/GB8904161D0/en
Priority to GB8904161 priority
Priority to GB898928210A priority patent/GB8928210D0/en
Priority to GB8928210 priority
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU5003390A publication Critical patent/AU5003390A/en
Application granted granted Critical
Publication of AU633051B2 publication Critical patent/AU633051B2/en
Anticipated expiration legal-status Critical
Application status is Ceased legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
AU50033/90A 1989-02-23 1990-02-21 Substituted pyrroles Ceased AU633051B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB898904161A GB8904161D0 (en) 1989-02-23 1989-02-23 Substituted pyrroles
GB8904161 1989-02-23
GB898928210A GB8928210D0 (en) 1989-02-23 1989-12-13 Substituted pyrroles
GB8928210 1989-12-13

Publications (2)

Publication Number Publication Date
AU5003390A true AU5003390A (en) 1990-08-30
AU633051B2 AU633051B2 (en) 1993-01-21

Family

ID=26295005

Family Applications (1)

Application Number Title Priority Date Filing Date
AU50033/90A Ceased AU633051B2 (en) 1989-02-23 1990-02-21 Substituted pyrroles

Country Status (20)

Country Link
EP (1) EP0384349B1 (en)
JP (1) JPH06102661B2 (en)
AT (1) AT104972T (en)
AU (1) AU633051B2 (en)
CA (1) CA2010636C (en)
CZ (1) CZ284587B6 (en)
DE (1) DE59005491D1 (en)
DK (1) DK0384349T3 (en)
DZ (1) DZ1399A1 (en)
ES (1) ES2052995T3 (en)
FI (1) FI93447C (en)
HU (1) HU206351B (en)
IE (1) IE64184B1 (en)
IL (1) IL93433A (en)
MC (1) MC2096A1 (en)
NO (1) NO174891C (en)
NZ (1) NZ232589A (en)
PT (1) PT93246B (en)
RU (2) RU2014332C1 (en)
SK (1) SK85590A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU649699B2 (en) * 1990-08-07 1994-06-02 F. Hoffmann-La Roche Ag Substituted pyrroles

Families Citing this family (46)

* Cited by examiner, † Cited by third party
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US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
DE4128015A1 (en) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellized 2- (piperazinoalkyl) indol derivatives and methods and intermediate products for their preparation and medicaments containing such compounds
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
EP0630241A1 (en) * 1992-03-20 1994-12-28 The Wellcome Foundation Limited Indole derivatives with antiviral activity
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
AT204579T (en) * 1993-12-07 2001-09-15 Lilly Co Eli Protein kinase C inhibitors
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
FI945705A (en) * 1993-12-07 1996-06-03 Lilly Co Eli Bisindolylmaleimides improved synthesis
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
DK0817627T3 (en) 1993-12-23 2005-06-06 Lilly Co Eli Inhibitors of protein kinase C
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
ES2123873T3 (en) * 1994-08-04 1999-01-16 Hoffmann La Roche Pyrrolocarbazole.
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
WO1996018626A1 (en) * 1994-12-13 1996-06-20 F. Hoffmann-La Roche Ag Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
EP0935463B1 (en) * 1996-10-31 2004-01-21 Harbor Branch Oceanographic Institution, Inc. Use of anti-neurogenic inflammatory compounds and compositions
EP1224932A4 (en) * 1999-08-20 2002-10-16 Sagami Chem Res Drugs inhibiting cell death
AT284885T (en) 2000-07-27 2005-01-15 Hoffmann La Roche 3-indolyl-4-phenyl-1h-pyrrol-2,5-dion derivatives as glycogen synthase kinase 3beta inhibitors
BR0116468A (en) 2000-12-08 2004-06-29 Ortho Mcneil Pharm Inc substituted pyrroline compounds of kinase inhibitors as indazolila
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20070191338A1 (en) 2003-08-08 2007-08-16 Atadja Peter W Combinations comprising staurosporines
RU2372348C2 (en) * 2004-01-19 2009-11-10 Новартис Аг Indolylmaleimide derivatives as protein kinase c (pkc) inhibitors
EP1819697B1 (en) 2004-12-08 2012-08-01 Johannes Gutenberg-Universität Mainz 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
ZA200706530B (en) 2005-02-09 2009-01-28 Arqule Inc Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
EP2246346B1 (en) * 2005-07-11 2012-10-24 Novartis AG Indolylmaleimide derivatives as protein kinase inhibitors
WO2007019675A1 (en) * 2005-08-12 2007-02-22 Merck Frosst Canada Ltd. Indole derivatives as crth2 receptor antagonists
EP1980561B1 (en) 2007-03-30 2013-10-09 Nerviano Medical Sciences S.R.L. Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors
WO2009002808A2 (en) 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
JP5425060B2 (en) * 2007-06-22 2014-02-26 アークル インコーポレイテッド Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for the treatment of cancer
CA2912546A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Compositions and methods for treatment of cancer
US8637671B2 (en) 2008-09-22 2014-01-28 Merck Canada Inc. Indole derivatives as CRTH2 receptor antagonists
EP2343291A1 (en) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds
EP2474541A1 (en) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
EP2989104B1 (en) * 2013-04-23 2019-08-21 Esteve Pharmaceuticals, S.A. Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
US20170209488A1 (en) 2014-07-17 2017-07-27 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
EP3187495A1 (en) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (en) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituted pyrroles, their use for preparing medicaments and medicaments based thereon
US5049563A (en) * 1988-07-07 1991-09-17 Duphar International Research B.V. Annelated indoleketones with an imidazolylalkyl substituent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU649699B2 (en) * 1990-08-07 1994-06-02 F. Hoffmann-La Roche Ag Substituted pyrroles

Also Published As

Publication number Publication date
SK85590A3 (en) 1998-01-14
NO900855L (en) 1990-08-24
FI900863A0 (en) 1990-02-21
CZ284587B6 (en) 1999-01-13
AU633051B2 (en) 1993-01-21
HU900846D0 (en) 1990-04-28
CA2010636C (en) 1999-12-14
IL93433A (en) 1996-11-14
MC2096A1 (en) 1991-02-15
DK0384349T3 (en) 1994-09-05
RU2142460C1 (en) 1999-12-10
AT104972T (en) 1994-05-15
FI93447B (en) 1994-12-30
IL93433D0 (en) 1990-11-29
NZ232589A (en) 1992-09-25
NO174891C (en) 1994-07-27
EP0384349A1 (en) 1990-08-29
RU2014332C1 (en) 1994-06-15
PT93246B (en) 1996-01-31
FI900863D0 (en)
NO174891B (en) 1994-04-18
CZ85590A3 (en) 1998-10-14
JPH02264776A (en) 1990-10-29
EP0384349B1 (en) 1994-04-27
IE64184B1 (en) 1995-07-12
PT93246A (en) 1990-08-31
HU206351B (en) 1992-10-28
CA2010636A1 (en) 1990-08-23
FI93447C (en) 1995-04-10
ES2052995T3 (en) 1994-07-16
NO900855D0 (en) 1990-02-22
DZ1399A1 (en) 2004-09-13
JPH06102661B2 (en) 1994-12-14
HUT53369A (en) 1990-10-28
IE900647L (en) 1990-08-23
SK278711B6 (en) 1998-01-14
DE59005491D1 (en) 1994-06-01

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