FI900863A0 - Analogous process for the preparation of therapeutically useful 3- (tetrahydropyrido-, dihydropyrrolo- and tetrahydropyrazino / 1,2-a / indol-10-yl) pyrrole-2,5-dione derivatives - Google Patents

Analogous process for the preparation of therapeutically useful 3- (tetrahydropyrido-, dihydropyrrolo- and tetrahydropyrazino / 1,2-a / indol-10-yl) pyrrole-2,5-dione derivatives

Info

Publication number
FI900863A0
FI900863A0 FI900863A FI900863A FI900863A0 FI 900863 A0 FI900863 A0 FI 900863A0 FI 900863 A FI900863 A FI 900863A FI 900863 A FI900863 A FI 900863A FI 900863 A0 FI900863 A0 FI 900863A0
Authority
FI
Finland
Prior art keywords
pyrrole
tetrahydropyrazino
dihydropyrrolo
tetrahydropyrido
indol
Prior art date
Application number
FI900863A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI93447C (en
FI93447B (en
Inventor
Peter David Davis
Christopher Huw Hill
Geoffrey Lawton
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898904161A external-priority patent/GB8904161D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI900863A0 publication Critical patent/FI900863A0/en
Application granted granted Critical
Publication of FI93447B publication Critical patent/FI93447B/en
Publication of FI93447C publication Critical patent/FI93447C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The pyrrole derivatives of the formula <IMAGE> in which R<1> to R<8>, R, X, Y and m have the meaning given in the description, are therapeutically active substances, in particular for use as substances having antiinflammatory, immunological, oncological, bronchopulmonary and cardiovascular activity or as active substances in the treatment of asthma or AIDS. They are prepared from corresponding furandione derivatives in which X and Y stand for =N-R or O.
FI900863A 1989-02-23 1990-02-21 Analogous process for the preparation of therapeutically useful 3- (tetrahydropyrido, dihydropyrrolo and tetrahydropyrazino [1,2-a] indol-10-yl) pyrrole-2,5-dione derivatives FI93447C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8904161 1989-02-23
GB898904161A GB8904161D0 (en) 1989-02-23 1989-02-23 Substituted pyrroles
GB898928210A GB8928210D0 (en) 1989-02-23 1989-12-13 Substituted pyrroles
GB8928210 1989-12-13

Publications (3)

Publication Number Publication Date
FI900863A0 true FI900863A0 (en) 1990-02-21
FI93447B FI93447B (en) 1994-12-30
FI93447C FI93447C (en) 1995-04-10

Family

ID=26295005

Family Applications (1)

Application Number Title Priority Date Filing Date
FI900863A FI93447C (en) 1989-02-23 1990-02-21 Analogous process for the preparation of therapeutically useful 3- (tetrahydropyrido, dihydropyrrolo and tetrahydropyrazino [1,2-a] indol-10-yl) pyrrole-2,5-dione derivatives

Country Status (20)

Country Link
EP (1) EP0384349B1 (en)
JP (1) JPH06102661B2 (en)
AT (1) ATE104972T1 (en)
AU (1) AU633051B2 (en)
CA (1) CA2010636C (en)
CZ (1) CZ284587B6 (en)
DE (1) DE59005491D1 (en)
DK (1) DK0384349T3 (en)
DZ (1) DZ1399A1 (en)
ES (1) ES2052995T3 (en)
FI (1) FI93447C (en)
HU (1) HU206351B (en)
IE (1) IE64184B1 (en)
IL (1) IL93433A (en)
MC (1) MC2096A1 (en)
NO (1) NO174891C (en)
NZ (1) NZ232589A (en)
PT (1) PT93246B (en)
RU (2) RU2142460C1 (en)
SK (1) SK85590A3 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
DE4128015A1 (en) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-ANELLIZED 2- (PIPERAZINOALKYL) INDOL DERIVATIVES AND METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING SUCH COMPOUNDS
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
EP0630241A1 (en) * 1992-03-20 1994-12-28 The Wellcome Foundation Limited Indole derivatives with antiviral activity
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
ES2134910T3 (en) * 1993-12-07 1999-10-16 Lilly Co Eli SYNTHESIS OF BISINDOLILMALEIMIDAS.
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
HU219709B (en) * 1993-12-07 2001-06-28 Eli Lilly And Co. Condensed indole derivatives of protein kinase c inhibitor activity, process for preparing them and pharmaceutical compositions containing them
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
PT817627E (en) 1993-12-23 2005-07-29 Lilly Co Eli PROTEIN INHIBITORS CINASE C
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
DE69505470T2 (en) * 1994-08-04 1999-05-12 F. Hoffmann-La Roche Ag, Basel Pyrrolocarbazole
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
DK0797575T3 (en) * 1994-12-13 2004-02-16 Hoffmann La Roche Imidazole derivatives as protein kinase inhibitors, especially EGF-R tyrosine kinase
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
ATE258050T1 (en) * 1996-10-31 2004-02-15 Harbor Branch Oceanographic USE OF NEUROGENIC ANTI-INFLAMMATORY COMPOUNDS AND COMPOSITIONS
EP1224932A4 (en) * 1999-08-20 2002-10-16 Sagami Chem Res Drugs inhibiting cell death
PL366701A1 (en) 2000-07-27 2005-02-07 F.Hoffmann-La Roche Ag 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
MXPA03005140A (en) 2000-12-08 2004-10-15 Johnson & Johnson Indazolyl-substituted pyrroline compounds as kinase inhibitors.
TWI335221B (en) 2001-09-27 2011-01-01 Alcon Inc Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
CA2533861A1 (en) 2003-08-08 2005-02-17 Novartis Ag Combinations comprising staurosporines
ES2402298T3 (en) * 2004-01-19 2013-04-30 Novartis Ag Indolylmaleimide derivatives as inhibitors of graft rejection treatment or autoimmune diseases
AU2005313485B2 (en) 2004-12-08 2011-02-03 Johannes Gutenberg-Universitat Mainz 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
EP1846406B9 (en) 2005-02-09 2012-01-11 ArQule, Inc. Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
KR20080023732A (en) 2005-07-11 2008-03-14 노파르티스 아게 Indolylmaleimide derivatives
ES2443022T3 (en) * 2005-08-12 2014-02-17 Merck Frosst Canada Inc. Indole derivatives as CRTH2 receptor antagonists
EP1980561B1 (en) 2007-03-30 2013-10-09 Nerviano Medical Sciences S.R.L. Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors
CN101801969B (en) 2007-06-22 2014-10-29 艾科尔公司 Indolyl pyrrolidines for the treatment of cancer
JP2010530885A (en) 2007-06-22 2010-09-16 アークル インコーポレイテッド Quinazolinone compounds and methods of use thereof
EP2170870B1 (en) * 2007-06-22 2014-03-05 ArQule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
AU2009295230A1 (en) * 2008-09-22 2010-03-25 Merck Canada Inc. Indole derivatives as CRTH2 receptor antagonists
EP2343291A1 (en) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds
EP2474541A1 (en) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
KR20160003752A (en) * 2013-04-23 2016-01-11 라보라토리오스 델 드라. 에스테브.에스.에이. Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
JP2017524739A (en) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ Method for treating neuromuscular junction related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
EP3187495A1 (en) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89167A (en) * 1988-02-10 1994-02-27 Hoffmann La Roche Substituted pyrroles, their manufacture and pharmaceutical compositions containing them
EP0350129A1 (en) * 1988-07-07 1990-01-10 Duphar International Research B.V New annelated indoleketones with an imidazolylalkyl substituent

Also Published As

Publication number Publication date
HU900846D0 (en) 1990-04-28
IL93433A (en) 1996-11-14
DK0384349T3 (en) 1994-09-05
CA2010636A1 (en) 1990-08-23
AU5003390A (en) 1990-08-30
RU2014332C1 (en) 1994-06-15
CA2010636C (en) 1999-12-14
EP0384349A1 (en) 1990-08-29
AU633051B2 (en) 1993-01-21
MC2096A1 (en) 1991-02-15
NO174891C (en) 1994-07-27
DZ1399A1 (en) 2004-09-13
SK278711B6 (en) 1998-01-14
PT93246A (en) 1990-08-31
CZ284587B6 (en) 1999-01-13
NO174891B (en) 1994-04-18
HUT53369A (en) 1990-10-28
FI93447C (en) 1995-04-10
CZ85590A3 (en) 1998-10-14
IL93433A0 (en) 1990-11-29
FI93447B (en) 1994-12-30
IE64184B1 (en) 1995-07-12
SK85590A3 (en) 1998-01-14
NO900855L (en) 1990-08-24
EP0384349B1 (en) 1994-04-27
PT93246B (en) 1996-01-31
ES2052995T3 (en) 1994-07-16
IE900647L (en) 1990-08-23
NZ232589A (en) 1992-09-25
NO900855D0 (en) 1990-02-22
JPH06102661B2 (en) 1994-12-14
HU206351B (en) 1992-10-28
ATE104972T1 (en) 1994-05-15
DE59005491D1 (en) 1994-06-01
JPH02264776A (en) 1990-10-29
RU2142460C1 (en) 1999-12-10

Similar Documents

Publication Publication Date Title
FI900863A0 (en) Analogous process for the preparation of therapeutically useful 3- (tetrahydropyrido-, dihydropyrrolo- and tetrahydropyrazino / 1,2-a / indol-10-yl) pyrrole-2,5-dione derivatives
CA2102179A1 (en) Quinuclidine derivatives
AU5061190A (en) Novel benzimidazole and azabenzimidazole derivatives, their methods of preparation, synthesis intermediates and pharmaceutical compositions in which they are present and which are useful especially for the treatment of cardiovascular diseases and duodenal ulcers
RU93033479A (en) METHOD FOR OBTAINING SUBSTITUTED PYRROLES, METHOD FOR OBTAINING PHARMACEUTICAL PREPARATIONS
AU7535087A (en) The process for the manufacture of spiro-linked pyrrolidine-2,5-dione derivatives
NO873125L (en) PROCEDURE FOR THE MANUFACTURE OF ANTIBACTERIAL COMPOUNDS.
TR200001141T2 (en) Cyclopentene derivatives useful as motilin receptor antagonists.
DE69010257D1 (en) Process for the preparation of N-substituted maleimides.
CA2268399A1 (en) Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
ES2162856T3 (en) SEROTONINERGIC ERGOLINE DERIVATIVES.
AU529996B2 (en) Synthesis of vincaminic acid derivatives
EP0812844A3 (en) Use of theophyllin derivatives for the treatment and prophylaxis fo shock conditions, novel xanthine compounds and processes for the production thereof
ATE100102T1 (en) SUBSTITUTED DERIVATIVES OF 20,21DINOREBUNAMENINE, PROCESSES FOR THE MANUFACTURE AND INTERMEDIATE PRODUCTS SO MANUFACTURED, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
NO882959L (en) PROCEDURE FOR THE PREPARATION OF HIGH-DETERMINATING 3- (3-PYRIDYL) -1H, 3H-PYRROLO (1,2-C) TIAZOL-7-CARBOXYLIC ACID.
NO880405D0 (en) PROCEDURE FOR THE PREPARATION OF 3-PHENYL-7H-TIAZOLO- / 3,2-B // 1,2,4 / -TIAZINE-7-ONER.
DE68922596D1 (en) 3- (3-Ethyl-1,2,4-oxadiazol-5-yl) -1-azabicycloheptane, process for its preparation and pharmaceutical preparations containing it.
NO178890C (en) Analogous Process for the Preparation of Therapeutically Active Pyrrole [2,3-Bone Indole Ketones
IE780849L (en) Thienamycin derivatives

Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: F. HOFFMANN - LA ROCHE AG

MA Patent expired