RU93033479A - Способ получения замещенных пирролов, способ получения фармацевтических препаратов - Google Patents

Способ получения замещенных пирролов, способ получения фармацевтических препаратов

Info

Publication number
RU93033479A
RU93033479A RU93033479/04A RU93033479A RU93033479A RU 93033479 A RU93033479 A RU 93033479A RU 93033479/04 A RU93033479/04 A RU 93033479/04A RU 93033479 A RU93033479 A RU 93033479A RU 93033479 A RU93033479 A RU 93033479A
Authority
RU
Russia
Prior art keywords
obtaining
pharmaceutical preparations
substituted pyrroles
active substances
pyrroles
Prior art date
Application number
RU93033479/04A
Other languages
English (en)
Other versions
RU2142460C1 (ru
Inventor
Дейвид Дейвис Питер
Хю Хилл Кристофер
Лотен Джоффрей
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898904161A external-priority patent/GB8904161D0/en
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of RU93033479A publication Critical patent/RU93033479A/ru
Application granted granted Critical
Publication of RU2142460C1 publication Critical patent/RU2142460C1/ru

Links

Claims (1)

  1. Замещенные пиррола формулы
    Figure 00000001

    в которой R1 - R8, R, X, Y и m имеют указанные в описании значения, являются терапевтически активными веществами, в частности для применения в качестве антивоспалительных, иммунологических, онкологических, бронхолегочных и сердечно-сосудистых активных веществ или в качестве биологически активных веществ для лечения астмы или СПИДа.
RU93033479A 1989-02-23 1990-02-22 Замещенные пирролы и их фармацевтически приемлемые соли RU2142460C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8904161.0 1989-02-23
GB898904161A GB8904161D0 (en) 1989-02-23 1989-02-23 Substituted pyrroles
GB898928210A GB8928210D0 (en) 1989-02-23 1989-12-13 Substituted pyrroles
GB8928210.7 1989-12-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU4743198 Division

Publications (2)

Publication Number Publication Date
RU93033479A true RU93033479A (ru) 1996-04-20
RU2142460C1 RU2142460C1 (ru) 1999-12-10

Family

ID=26295005

Family Applications (2)

Application Number Title Priority Date Filing Date
RU93033479A RU2142460C1 (ru) 1989-02-23 1990-02-22 Замещенные пирролы и их фармацевтически приемлемые соли
SU904743198A RU2014332C1 (ru) 1989-02-23 1990-02-22 Способ получения замещенных пирролов или их фармацевтически приемлемых солей

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU904743198A RU2014332C1 (ru) 1989-02-23 1990-02-22 Способ получения замещенных пирролов или их фармацевтически приемлемых солей

Country Status (20)

Country Link
EP (1) EP0384349B1 (ru)
JP (1) JPH06102661B2 (ru)
AT (1) ATE104972T1 (ru)
AU (1) AU633051B2 (ru)
CA (1) CA2010636C (ru)
CZ (1) CZ284587B6 (ru)
DE (1) DE59005491D1 (ru)
DK (1) DK0384349T3 (ru)
DZ (1) DZ1399A1 (ru)
ES (1) ES2052995T3 (ru)
FI (1) FI93447C (ru)
HU (1) HU206351B (ru)
IE (1) IE64184B1 (ru)
IL (1) IL93433A (ru)
MC (1) MC2096A1 (ru)
NO (1) NO174891C (ru)
NZ (1) NZ232589A (ru)
PT (1) PT93246B (ru)
RU (2) RU2142460C1 (ru)
SK (1) SK278711B6 (ru)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
AU3761393A (en) * 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
DK0657411T3 (da) * 1993-12-07 1999-11-15 Lilly Co Eli Forbedret syntese af bisindolylmaleimider
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
HU219709B (hu) * 1993-12-07 2001-06-28 Eli Lilly And Co. Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
DK0817627T3 (da) 1993-12-23 2005-06-06 Lilly Co Eli Inhibitorer af proteinkinase C
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
EP0695755B1 (en) * 1994-08-04 1998-10-21 F. Hoffmann-La Roche AG Pyrrolocarbazole
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
WO1996018626A1 (en) * 1994-12-13 1996-06-20 F. Hoffmann-La Roche Ag Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
US5955462A (en) * 1996-10-31 1999-09-21 Harbor Branch Oceanographic Institution, Inc. Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
WO2001013916A1 (fr) * 1999-08-20 2001-03-01 Sagami Chemical Research Center Medicaments inhibant la mort cellulaire
CZ2003555A3 (en) 2000-07-27 2004-03-17 F. Hoffmann-La Roche Ag 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
MXPA03005140A (es) 2000-12-08 2004-10-15 Johnson & Johnson Compuestos de pirrolina sustituidos con indazolilo como inhibidores de cinasa.
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
BRPI0413439A (pt) 2003-08-08 2006-10-17 Novartis Ag combinações compreendendo estaurosporinas
PT1709030E (pt) * 2004-01-19 2008-07-01 Novartis Ag Derivados da indolilmaleimida
JP5289769B2 (ja) 2004-12-08 2013-09-11 ヨハネス、グーテンベルク−ウニフェルジテート、マインツ ３−（インドリル）−４−アリールマレイミド誘導体および脈管形成阻害剤としてのそれらの使用
CA2599611C (en) 2005-02-09 2013-07-30 Chiang J. Li Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
KR20080023732A (ko) 2005-07-11 2008-03-14 노파르티스 아게 인돌릴말레이미드 유도체
WO2007019675A1 (en) * 2005-08-12 2007-02-22 Merck Frosst Canada Ltd. Indole derivatives as crth2 receptor antagonists
EP1980561B1 (en) 2007-03-30 2013-10-09 Nerviano Medical Sciences S.R.L. Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors
WO2009002806A1 (en) * 2007-06-22 2008-12-31 Arqule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
BRPI0813355A2 (pt) 2007-06-22 2014-12-30 Arqule Inc Compostos de quinazolinona e métodos de uso dos mesmos
CA2912546A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Compositions and methods for treatment of cancer
WO2010031183A1 (en) * 2008-09-22 2010-03-25 Merck Frosst Canada Ltd. Indole derivatives as crth2 receptor antagonists
EP2343291A1 (en) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
WO2011082266A2 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted heterocyclic compounds
EP2474541A1 (en) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
EP2989104B1 (en) * 2013-04-23 2019-08-21 Esteve Pharmaceuticals, S.A. Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
EP3187495A1 (en) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (sk) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituované pyroly, ich použitie na výrobu lieči
US5049563A (en) * 1988-07-07 1991-09-17 Duphar International Research B.V. Annelated indoleketones with an imidazolylalkyl substituent

Similar Documents

Publication Publication Date Title
RU93033479A (ru) Способ получения замещенных пирролов, способ получения фармацевтических препаратов
DE59005491D1 (de) Substituierte Pyrrole.
DE3769379D1 (de) Entzuendungshemmende wirkstoffe, pharmazeutische zusammensetzungen und verfahren zur bekaempfung von entzuendungen.
RU93048636A (ru) 7-/замещенные/-8-/замещенные/-9-/замещенные амино/-6-диметил-6-дезокситетрациклины, промежуточные соединения, способы получения соединений, способ профилактики и лечения и фармацевтическая композиция
IT8547852A0 (it) Ciclosporine,processi per la loro preparazione,uso farmaceutico delle stesse e composizioni farmaceutiche che le contengono
CY2008012I2 (el) Υδροξυεστερες ραπαμυκινης, διαδικασια για τη παρασκευη τους και φαρμακευτικες συνθεσεις περιεχουσες αυτες
RU93041456A (ru) 9-(замещенный глицил)амидо)-6-деметил-6-дезокситетрациклины, способ их получения, промежуточный продукт, способ получения, фармацевтическая и ветеринарная композиция, способ лечения
RU95115135A (ru) Аналог долостатина
FI92603B (fi) Mikrobinen menetelmä syklosporiinien valmistamiseksi
DE69420229D1 (de) Pharmazeutische Zusammensetzung zur Behandlung von AIDS
IT1230483B (it) Procedimento per la produzione di una proteina endotossica, gene strutturale impiegato e composizioni insetticide comprendenti detta proteina
NO905543D0 (no) Fremgangsmaate for fremstilling og anvendelse av aminopyridinylmetanoler og aminometylpyridinaminer.
ITRM950143A0 (it) Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di composizioni farmaceutiche antipiretiche ed antinfiammatorie.
IT8721540A0 (it) Composizioni farmaceutiche contenenti trapidil, loro procedimento di preparazione erelativo impiego terapeutico.
DK0728741T3 (da) Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til fremstilling deraf, anvendelse deraf til fre
RU93052408A (ru) Ациламино-алкилиден-гидрокси-бис-фосфоновые кислоты, способ их получения, фармацевтическая композиция
RU94013447A (ru) НОВЫЕ ЦИС-N-ИМИНОМЕТИЛ-3,4-ДИЗАМЕЩЕННЫЕ- β -ЛАКТАМЫ, СПОСОБЫ ПОЛУЧЕНИЯ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ
IT1248838B (it) Soluzioni tampone contenenti collagenasi, loro preparazione ed uso perla diluizione di sieri umani
IT8747852A0 (it) Benzammidi sostituite, procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT8720179A0 (it) 2-sulfinil-acetil-1,3-tiazolidine, loro preparazione e composizioni farmaceutiche.
IT8619751A0 (it) Composizioni farmaceutiche contenenti vinburnina e loro procedimento di preparazione.
RU93004708A (ru) Производные замещенного пирролидина и их терапевтически приемлемые соли, способ их получения и фармацевтическая композиция
IT1229566B (it) Gel di antracicline e loro uso terapeutico.
ATE1388T1 (de) Lactyl-tetrapeptid, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zusammensetzungen.
ATE29663T1 (de) Kombinierte pharmazeutische zusammensetzung und zugehoeriges verfahren.