NO174891C - Analogifremgangsmåt ved fremstilling av terapeutisk aktive substituerte pyrroler - Google Patents

Analogifremgangsmåt ved fremstilling av terapeutisk aktive substituerte pyrroler

Info

Publication number
NO174891C
NO174891C NO900855A NO900855A NO174891C NO 174891 C NO174891 C NO 174891C NO 900855 A NO900855 A NO 900855A NO 900855 A NO900855 A NO 900855A NO 174891 C NO174891 C NO 174891C
Authority
NO
Norway
Prior art keywords
therapeutically active
analogous method
active substituted
preparing therapeutically
pyrrols
Prior art date
Application number
NO900855A
Other languages
English (en)
Norwegian (no)
Other versions
NO900855D0 (no
NO174891B (no
NO900855L (no
Inventor
Peter David Davis
Christopher Huw Hill
Geoffrey Lawton
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898904161A external-priority patent/GB8904161D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO900855D0 publication Critical patent/NO900855D0/no
Publication of NO900855L publication Critical patent/NO900855L/no
Publication of NO174891B publication Critical patent/NO174891B/no
Publication of NO174891C publication Critical patent/NO174891C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
NO900855A 1989-02-23 1990-02-22 Analogifremgangsmåt ved fremstilling av terapeutisk aktive substituerte pyrroler NO174891C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898904161A GB8904161D0 (en) 1989-02-23 1989-02-23 Substituted pyrroles
GB898928210A GB8928210D0 (en) 1989-02-23 1989-12-13 Substituted pyrroles

Publications (4)

Publication Number Publication Date
NO900855D0 NO900855D0 (no) 1990-02-22
NO900855L NO900855L (no) 1990-08-24
NO174891B NO174891B (no) 1994-04-18
NO174891C true NO174891C (no) 1994-07-27

Family

ID=26295005

Family Applications (1)

Application Number Title Priority Date Filing Date
NO900855A NO174891C (no) 1989-02-23 1990-02-22 Analogifremgangsmåt ved fremstilling av terapeutisk aktive substituerte pyrroler

Country Status (20)

Country Link
EP (1) EP0384349B1 (ru)
JP (1) JPH06102661B2 (ru)
AT (1) ATE104972T1 (ru)
AU (1) AU633051B2 (ru)
CA (1) CA2010636C (ru)
CZ (1) CZ284587B6 (ru)
DE (1) DE59005491D1 (ru)
DK (1) DK0384349T3 (ru)
DZ (1) DZ1399A1 (ru)
ES (1) ES2052995T3 (ru)
FI (1) FI93447C (ru)
HU (1) HU206351B (ru)
IE (1) IE64184B1 (ru)
IL (1) IL93433A (ru)
MC (1) MC2096A1 (ru)
NO (1) NO174891C (ru)
NZ (1) NZ232589A (ru)
PT (1) PT93246B (ru)
RU (2) RU2014332C1 (ru)
SK (1) SK278711B6 (ru)

Families Citing this family (47)

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Publication number Priority date Publication date Assignee Title
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
AU3761393A (en) * 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
AU678435B2 (en) 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
DE69418978T2 (de) * 1993-12-07 1999-10-28 Eli Lilly And Co., Indianapolis Synthese von Bisindolylmaleimiden
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
JP3581731B2 (ja) * 1993-12-07 2004-10-27 イーライ・リリー・アンド・カンパニー プロテインキナーゼｃ阻害物質
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
ATE456367T1 (de) * 1993-12-23 2010-02-15 Lilly Co Eli Proteinkinase c inhibitoren
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
DE69505470T2 (de) * 1994-08-04 1999-05-12 F. Hoffmann-La Roche Ag, Basel Pyrrolocarbazol
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
AU4301096A (en) * 1994-12-13 1996-07-03 F. Hoffmann-La Roche Ag Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
ATE258050T1 (de) * 1996-10-31 2004-02-15 Harbor Branch Oceanographic Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen
WO2001013916A1 (fr) * 1999-08-20 2001-03-01 Sagami Chemical Research Center Medicaments inhibant la mort cellulaire
AU2001293702A1 (en) 2000-07-27 2002-02-13 F. Hoffmann-La Roche Ag 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
CN1230434C (zh) 2000-12-08 2005-12-07 奥索-麦克尼尔药品公司 用作激酶抑制剂的吲唑基取代的吡咯啉化合物
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
EP2305265A1 (en) 2003-08-08 2011-04-06 Novartis AG Combinations comprising staurosporines
RU2373201C2 (ru) * 2004-01-19 2009-11-20 Новартис Аг Индолилмалеимидные производные
AU2005313485B2 (en) 2004-12-08 2011-02-03 Johannes Gutenberg-Universitat Mainz 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
NZ560225A (en) 2005-02-09 2010-10-29 Arqule Inc Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
BRPI0613064A2 (pt) 2005-07-11 2010-12-21 Novartis Ag derivados de indolilmaleimida como inibidores de proteìna quinase
AU2006281937B2 (en) * 2005-08-12 2011-11-17 Merck Canada Inc. Indole derivatives as CRTH2 receptor antagonists
EP1980561B1 (en) 2007-03-30 2013-10-09 Nerviano Medical Sciences S.R.L. Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors
CA2690799C (en) 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
ATE522531T1 (de) 2007-06-22 2011-09-15 Arqule Inc Indolylpyrrolidine zur behandlung von krebs
AU2008268613A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
EP2346865B1 (en) * 2008-09-22 2015-07-15 Merck Canada Inc. Indole derivatives as crth2 receptor antagonists
EP2343291A1 (en) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
WO2011082266A2 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted heterocyclic compounds
EP2474541A1 (en) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
WO2014173901A1 (en) * 2013-04-23 2014-10-30 Laboratorios Del Dr. Esteve, S.A. PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS
EP3741375A1 (en) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
EP3187495A1 (en) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
IL89167A (en) * 1988-02-10 1994-02-27 Hoffmann La Roche Substituted pyrroles, their manufacture and pharmaceutical compositions containing them
US5049563A (en) * 1988-07-07 1991-09-17 Duphar International Research B.V. Annelated indoleketones with an imidazolylalkyl substituent

Also Published As

Publication number Publication date
HU206351B (en) 1992-10-28
NZ232589A (en) 1992-09-25
FI93447C (fi) 1995-04-10
PT93246A (pt) 1990-08-31
RU2142460C1 (ru) 1999-12-10
SK85590A3 (en) 1998-01-14
DK0384349T3 (da) 1994-09-05
IE900647L (en) 1990-08-23
CZ284587B6 (cs) 1999-01-13
NO900855D0 (no) 1990-02-22
IE64184B1 (en) 1995-07-12
NO174891B (no) 1994-04-18
NO900855L (no) 1990-08-24
AU5003390A (en) 1990-08-30
DE59005491D1 (de) 1994-06-01
ES2052995T3 (es) 1994-07-16
AU633051B2 (en) 1993-01-21
IL93433A0 (en) 1990-11-29
FI900863A0 (fi) 1990-02-21
EP0384349B1 (de) 1994-04-27
HUT53369A (en) 1990-10-28
ATE104972T1 (de) 1994-05-15
JPH02264776A (ja) 1990-10-29
DZ1399A1 (fr) 2004-09-13
JPH06102661B2 (ja) 1994-12-14
MC2096A1 (fr) 1991-02-15
FI93447B (fi) 1994-12-30
CZ85590A3 (cs) 1998-10-14
CA2010636A1 (en) 1990-08-23
SK278711B6 (sk) 1998-01-14
PT93246B (pt) 1996-01-31
EP0384349A1 (de) 1990-08-29
CA2010636C (en) 1999-12-14
RU2014332C1 (ru) 1994-06-15
HU900846D0 (en) 1990-04-28
IL93433A (en) 1996-11-14

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