DE764052A - - Google Patents
Info
- Publication number
- DE764052A DE764052A DE764052A DE 764052 A DE764052 A DE 764052A DE 764052 A DE764052 A DE 764052A
- Authority
- DE
- Germany
- Prior art keywords
- phosphoric acid
- acid
- parts
- bactericidal
- sulfanilamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 27
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 14
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 claims description 13
- 229940124530 sulfonamide Drugs 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 230000000844 anti-bacterial effect Effects 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 claims description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 3
- 150000003016 phosphoric acids Chemical class 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000543 intermediate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 16
- 235000011007 phosphoric acid Nutrition 0.000 description 13
- HVBSAKJJOYLTQU-UHFFFAOYSA-N 4-aminobenzenesulfonic acid Chemical class NC1=CC=C(S(O)(=O)=O)C=C1 HVBSAKJJOYLTQU-UHFFFAOYSA-N 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 10
- 239000002253 acid Substances 0.000 description 9
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical class ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 9
- 230000007935 neutral effect Effects 0.000 description 6
- 235000011121 sodium hydroxide Nutrition 0.000 description 6
- 229950000244 sulfanilic acid Drugs 0.000 description 6
- -1 sulfanilic acid anilides Chemical class 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- PLFVUCZOCWPMCI-UHFFFAOYSA-N 4,4-diamino-2-(benzenesulfonyl)-N,N-dimethylcyclohexa-1,5-diene-1-sulfonamide Chemical compound CN(S(=O)(C1=C(CC(C=C1)(N)N)S(=O)(=O)C1=CC=CC=C1)=O)C PLFVUCZOCWPMCI-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 241000906446 Theraps Species 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 229940051881 anilide analgesics and antipyretics Drugs 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000001226 reprecipitation Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- CWGIAARBWIMMCV-UHFFFAOYSA-N 4,4-diamino-2-(benzenesulfonyl)cyclohexa-1,5-diene-1-sulfonamide Chemical compound NC1(CC(=C(S(=O)(=O)N)C=C1)S(=O)(=O)C1=CC=CC=C1)N CWGIAARBWIMMCV-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000034762 Meningococcal Infections Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 150000003931 anilides Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012084 conversion product Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- CKTNHGVJKUQEBM-UHFFFAOYSA-N ethylazanide Chemical compound CC[NH-] CKTNHGVJKUQEBM-UHFFFAOYSA-N 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000005331 phenylglycines Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2745083C2 (de) | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung | |
| DE2534391C2 (de) | 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren | |
| DE2329485C3 (de) | Platinkoordinationsverbindungen und ein diese Verbindungen enthaltendes Antitumormittel | |
| DE1767891B2 (de) | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat | |
| DE2359333A1 (de) | Verfahren zur herstellung eines dopapraeparats | |
| DE1770171C3 (de) | 2,2-Dimethyl-7-alkyl-4-(4-pyridyl)-2H-chromen-5-ole, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneipräparate | |
| DE764052A (enrdf_load_html_response) | ||
| DE1223396B (de) | Verfahren zur Herstellung von Trinatriumsalzen der Zinkkomplexe der Diaethylentriamin-N, N. N', N", N"-pentaessigsaeure und der Triaethylentetramin-N, N, N', N", N''', N'''-hexaessigsaeure | |
| DE2745084A1 (de) | Diphosphonsaeuren | |
| DE568943C (de) | Verfahren zur Darstellung von unsymmetrischen Arsenoverbindungen | |
| DE854952C (de) | Verfahren zur Herstellung von komplexen Aureomycin-Verbindungen | |
| DE275092C (enrdf_load_html_response) | ||
| DE606498C (de) | Verfahren zur Darstellung von Salzen aus Acylaminoarylarsinsaeuren und Acridiniumverbindungen | |
| DE555241C (de) | Verfahren zur Herstellung von aminosubstituierten Guajacolarsinsaeuren und deren Reduktionsprodukten | |
| DE873599C (de) | Verfahren zur Herstellung von Penicillinverbindungen mit verlaengerter Wirkung | |
| DE513205C (de) | Verfahren zur Herstellung von Derivaten der Aminoarylantimonverbindungen | |
| DE1922578C3 (de) | 4,7,10-Trioxatrldecan-1,13-dioyibis-(3-carboxy-2,4,6-trijod-anilid) und dessen Salze, Verfahren zur Herstellung dieser Verbindungen sowie diese Verbindungen enthaltende Röntgenkontrastmittel | |
| DE414799C (de) | Verfahren zur Darstellung von komplexen Verbindungen des Wismuts mit Arsenobenzolderivaten | |
| DE948185C (de) | Verfahren zur Herstellung haltbarer wasserloeslicher Produkte von loeslichen Salzen der p-Naphthionsaeure mit Adrenochromverbindungen | |
| AT151657B (de) | Verfahren zur Darstellung von Formaldehydnatriumsulfoxylaten von Arsenobenzolverbindungen. | |
| DE606941C (de) | Verfahren zur Herstellung von Loesungen von Acridinsalzen | |
| DE2235400C3 (de) | ^Chlor-S-sulfamoyl-anthranilsäuren, deren Salze, Verfahren zur Herstellung dieser Verbindungen und diese Verbindungen enthaltende Arzneimittel | |
| DE388669C (de) | Verfahren zur Herstellung eines Silbersalzes der Bordisalicylsaeure | |
| DE605074C (de) | Verfahren zur Herstellung von Verbindungen der Sulfhydrylkeratinsaeure und aehnlicher reduzierter Abbauprodukte des Keratins mit organischen, Arsen enthaltenden Verbindungen | |
| DE494508C (de) | Verfahren zur Darstellung eines Kondensationsproduktes aus m-Kresol und Aceton |