DE69937239T2 - Herpesvirusvektoren für dendritische zellen - Google Patents
Herpesvirusvektoren für dendritische zellen Download PDFInfo
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- DE69937239T2 DE69937239T2 DE69937239T DE69937239T DE69937239T2 DE 69937239 T2 DE69937239 T2 DE 69937239T2 DE 69937239 T DE69937239 T DE 69937239T DE 69937239 T DE69937239 T DE 69937239T DE 69937239 T2 DE69937239 T2 DE 69937239T2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9816781.0A GB9816781D0 (en) | 1998-07-31 | 1998-07-31 | Herpes virus vectors for dendritic cells |
| GB9816781 | 1998-07-31 | ||
| PCT/GB1999/002529 WO2000008191A2 (en) | 1998-07-31 | 1999-08-02 | Herpes virus vectors for dendritic cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69937239D1 DE69937239D1 (de) | 2007-11-15 |
| DE69937239T2 true DE69937239T2 (de) | 2008-07-24 |
Family
ID=10836553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69937239T Expired - Lifetime DE69937239T2 (de) | 1998-07-31 | 1999-08-02 | Herpesvirusvektoren für dendritische zellen |
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| Country | Link |
|---|---|
| US (2) | US6641817B1 (enExample) |
| EP (1) | EP1100942B1 (enExample) |
| JP (1) | JP4430824B2 (enExample) |
| KR (1) | KR100635246B1 (enExample) |
| CN (1) | CN1384884B (enExample) |
| AT (1) | ATE374829T1 (enExample) |
| AU (1) | AU765105B2 (enExample) |
| BR (1) | BR9912653A (enExample) |
| CA (1) | CA2337494C (enExample) |
| CY (1) | CY1107844T1 (enExample) |
| DE (1) | DE69937239T2 (enExample) |
| DK (1) | DK1100942T3 (enExample) |
| ES (1) | ES2294848T3 (enExample) |
| GB (2) | GB9816781D0 (enExample) |
| IL (1) | IL141126A0 (enExample) |
| PT (1) | PT1100942E (enExample) |
| WO (1) | WO2000008191A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
| CA2347067C (en) | 1998-03-31 | 2013-09-17 | Geron Corporation | Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer |
| GB0009079D0 (en) * | 2000-04-12 | 2000-05-31 | Neurovex Ltd | Herpes viruses for immune modulation |
| US6713067B2 (en) * | 1998-07-31 | 2004-03-30 | Biovex Limited | Herpes viruses for immune modulation |
| GB9816781D0 (en) * | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
| US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| US7223593B2 (en) * | 2000-01-21 | 2007-05-29 | Biovex Limited | Herpes virus strains for gene therapy |
| US7063851B2 (en) | 2000-04-12 | 2006-06-20 | Biovex Limited | Herpes viruses for immune modulation |
| JP2004529158A (ja) * | 2001-05-02 | 2004-09-24 | ラモツト・アツト・テル−アビブ・ユニバーシテイ・リミテツド | 混成殺腫瘍ヘルペスウイルスベクター |
| EP1387694A2 (en) * | 2001-05-09 | 2004-02-11 | M'S Science Corporation | Composition and method for treating cancer using herpes virus |
| GB0203285D0 (en) | 2002-02-12 | 2002-03-27 | Brown Susanne M | An herpes simplex virus complex |
| US8216564B2 (en) | 2002-05-02 | 2012-07-10 | Ramot At Tel-Aviv University Ltd. | Composite oncolytic herpes virus vectors |
| JP2004099584A (ja) * | 2002-05-02 | 2004-04-02 | Keio Gijuku | Ｈｓｖを用いた抗腫瘍剤 |
| CA2421269A1 (en) | 2002-08-09 | 2004-02-09 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| GB0317511D0 (en) * | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
| WO2007016239A2 (en) * | 2005-07-29 | 2007-02-08 | President And Fellows Of Harvard College | Herpes simplex virus mutant and uses therefore |
| KR100878017B1 (ko) * | 2007-04-09 | 2009-01-14 | 인제대학교 산학협력단 | 이종 유전자 발현을 위한 숙주균 및 그의 이용방법 |
| US9181315B2 (en) | 2009-01-08 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for induced brown fat differentiation |
| EP2408904B1 (en) | 2009-03-20 | 2017-10-18 | Mesoblast, Inc. | Production of reprogrammed pluripotent cells |
| AU2011207348A1 (en) | 2010-01-21 | 2012-08-02 | Dana-Farber Cancer Institute, Inc. | Context specific genetic screen platform to aid in gene discovery and target validation |
| US9539427B2 (en) | 2010-11-08 | 2017-01-10 | The Johns Hopkins University | Methods for improving heart function |
| US8969519B2 (en) | 2011-09-13 | 2015-03-03 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for brown fat induction and activity using FNDC5 |
| WO2013055911A1 (en) | 2011-10-14 | 2013-04-18 | Dana-Farber Cancer Institute, Inc. | Znf365/zfp365 biomarker predictive of anti-cancer response |
| CA2944903A1 (en) | 2014-04-24 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
| WO2016057367A1 (en) | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response |
| CA2963602A1 (en) | 2014-10-09 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Multiple-variable il-2 dose regimen for treating immune disorders |
| EP3265825A4 (en) | 2015-03-06 | 2018-08-08 | Dana-Farber Cancer Institute, Inc. | Pd-l2 biomarkers predictive of pd-1 pathway inhibitor responses in esophagogastric cancers |
| CN105219738A (zh) * | 2015-09-21 | 2016-01-06 | 北京神源德生物科技有限公司 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
| CN105219739A (zh) * | 2015-09-21 | 2016-01-06 | 北京神源德生物科技有限公司 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
| EP3362074B1 (en) | 2015-10-16 | 2023-08-09 | President and Fellows of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
| AU2016343978A1 (en) | 2015-10-29 | 2018-05-17 | Dana-Farber Cancer Institute, Inc. | Methods for identification, assessment, prevention, and treatment of metabolic disorders using PM20D1 and N-lipidated amino acids |
| JP2019512271A (ja) | 2016-03-21 | 2019-05-16 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｔ細胞疲弊状態特異的遺伝子発現調節因子およびその使用 |
| CA3034643A1 (en) | 2016-09-20 | 2018-03-29 | Ellen Weisberg | Compositions and methods for identification, assessment, prevention, and treatment of aml using usp10 biomarkers and modulators |
| US11820822B2 (en) | 2017-06-06 | 2023-11-21 | Dana-Farber Cancer Institute, Inc. | Methods for sensitizing cancer cells to T cell-mediated killing by modulating molecular pathways |
| EP3759125A4 (en) | 2018-02-28 | 2021-12-08 | Dana-Farber Cancer Institute, Inc. | CANCER TREATMENT METHODS USING COMBINATIONS OF ANTI-BTNL2 BLOCKING AGENTS AND IMMUNE CHECKPOINTS |
| CN111867637B (zh) * | 2018-03-19 | 2024-05-03 | 勃林格殷格翰动物保健有限公司 | 新ehv插入位点ul43 |
| WO2019204057A1 (en) | 2018-04-06 | 2019-10-24 | Dana-Farber Cancer Institute, Inc. | Kir3dl3 as an hhla2 receptor, anti-hhla2 antibodies, and uses thereof |
| WO2020223121A1 (en) | 2019-04-30 | 2020-11-05 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer using combinations of anti-cx3cr1 and immune checkpoint blockade agents |
| US20230075965A1 (en) | 2020-01-24 | 2023-03-09 | Constantine S. Mitsiades | Uses of biomarkers for improving immunotherapy |
| US20230374599A1 (en) | 2020-10-19 | 2023-11-23 | Alexander Gusev | Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy |
| WO2022104104A2 (en) | 2020-11-13 | 2022-05-19 | Dana-Farber Cancer Institute, Inc. | Personalized fusion cell vaccines |
| EP4288140A1 (en) | 2021-02-05 | 2023-12-13 | Iovance Biotherapeutics, Inc. | Adjuvant therapy for cancer |
| US20240280561A1 (en) | 2021-06-08 | 2024-08-22 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating and/or identifying an agent for treating intestinal cancers |
| US20250381241A1 (en) | 2021-11-29 | 2025-12-18 | Dana-Farber Cancer Institute, Inc. | Methods and compositions to modulate riok2 |
| WO2023158732A1 (en) | 2022-02-16 | 2023-08-24 | Dana-Farber Cancer Institute, Inc. | Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof |
| WO2025034542A1 (en) | 2023-08-04 | 2025-02-13 | Cornell University | Gene signature panel predicting cancer response to immune checkpoint blockade and radiation therapy |
Family Cites Families (6)
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|---|---|---|---|---|
| DE69332501T3 (de) * | 1992-07-31 | 2009-03-26 | The President And Fellows Of Harvard College, Cambridge | Herpesvirus impfstoffe |
| GB9615794D0 (en) | 1996-07-26 | 1996-09-04 | Medical Res Council | Mutant herpes simplex virus strains and uses thereof |
| US5998174A (en) | 1997-05-12 | 1999-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Multigene vectors |
| GB9816781D0 (en) * | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
| US6713067B2 (en) * | 1998-07-31 | 2004-03-30 | Biovex Limited | Herpes viruses for immune modulation |
| US7063851B2 (en) * | 2000-04-12 | 2006-06-20 | Biovex Limited | Herpes viruses for immune modulation |
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1998
- 1998-07-31 GB GBGB9816781.0A patent/GB9816781D0/en not_active Ceased
-
1999
- 1999-08-02 AU AU51822/99A patent/AU765105B2/en not_active Expired
- 1999-08-02 JP JP2000563814A patent/JP4430824B2/ja not_active Expired - Lifetime
- 1999-08-02 DE DE69937239T patent/DE69937239T2/de not_active Expired - Lifetime
- 1999-08-02 GB GB0104400A patent/GB2361921B/en not_active Expired - Lifetime
- 1999-08-02 CA CA002337494A patent/CA2337494C/en not_active Expired - Lifetime
- 1999-08-02 CN CN99811376XA patent/CN1384884B/zh not_active Expired - Lifetime
- 1999-08-02 IL IL14112699A patent/IL141126A0/xx not_active IP Right Cessation
- 1999-08-02 BR BR9912653-2A patent/BR9912653A/pt not_active IP Right Cessation
- 1999-08-02 ES ES99936848T patent/ES2294848T3/es not_active Expired - Lifetime
- 1999-08-02 US US09/744,942 patent/US6641817B1/en not_active Expired - Lifetime
- 1999-08-02 PT PT99936848T patent/PT1100942E/pt unknown
- 1999-08-02 AT AT99936848T patent/ATE374829T1/de active
- 1999-08-02 EP EP99936848A patent/EP1100942B1/en not_active Expired - Lifetime
- 1999-08-02 KR KR1020017001361A patent/KR100635246B1/ko not_active Expired - Lifetime
- 1999-08-02 DK DK99936848T patent/DK1100942T3/da active
- 1999-08-02 WO PCT/GB1999/002529 patent/WO2000008191A2/en not_active Ceased
-
2005
- 2005-06-20 US US11/155,688 patent/US20050249707A1/en not_active Abandoned
-
2007
- 2007-12-27 CY CY20071101634T patent/CY1107844T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU765105B2 (en) | 2003-09-11 |
| JP2003502008A (ja) | 2003-01-21 |
| IL141126A0 (en) | 2002-02-10 |
| CN1384884A (zh) | 2002-12-11 |
| GB2361921A (en) | 2001-11-07 |
| CA2337494C (en) | 2009-06-23 |
| US6641817B1 (en) | 2003-11-04 |
| CY1107844T1 (el) | 2013-06-19 |
| DE69937239D1 (de) | 2007-11-15 |
| KR20010072162A (ko) | 2001-07-31 |
| GB9816781D0 (en) | 1998-09-30 |
| JP4430824B2 (ja) | 2010-03-10 |
| WO2000008191A3 (en) | 2000-06-08 |
| CN1384884B (zh) | 2010-12-08 |
| GB2361921B (en) | 2003-12-17 |
| CA2337494A1 (en) | 2000-02-17 |
| DK1100942T3 (da) | 2008-02-04 |
| KR100635246B1 (ko) | 2006-10-19 |
| WO2000008191A2 (en) | 2000-02-17 |
| EP1100942A2 (en) | 2001-05-23 |
| ATE374829T1 (de) | 2007-10-15 |
| US20050249707A1 (en) | 2005-11-10 |
| AU5182299A (en) | 2000-02-28 |
| BR9912653A (pt) | 2001-05-02 |
| PT1100942E (pt) | 2007-12-06 |
| EP1100942B1 (en) | 2007-10-03 |
| HK1037925A1 (en) | 2002-02-22 |
| GB0104400D0 (en) | 2001-04-11 |
| ES2294848T3 (es) | 2008-04-01 |
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