BR9912653A - Vìrus de herpes atenuado, cepa de vìrus, célula dendrìtica, processo para produzir um célula, composição farmacêutica, uso de um vìrus, e, processo para executar a terapia de gene em um paciente humano ou animal ou para tratar ou prevenir uma infecção patogênica ou câncer para tratar paciente animal - Google Patents
Vìrus de herpes atenuado, cepa de vìrus, célula dendrìtica, processo para produzir um célula, composição farmacêutica, uso de um vìrus, e, processo para executar a terapia de gene em um paciente humano ou animal ou para tratar ou prevenir uma infecção patogênica ou câncer para tratar paciente animalInfo
- Publication number
- BR9912653A BR9912653A BR9912653-2A BR9912653A BR9912653A BR 9912653 A BR9912653 A BR 9912653A BR 9912653 A BR9912653 A BR 9912653A BR 9912653 A BR9912653 A BR 9912653A
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- treat
- cell
- animal patient
- cancer
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 230000002238 attenuated effect Effects 0.000 title abstract 4
- 210000004443 dendritic cell Anatomy 0.000 title abstract 4
- 241001529453 unidentified herpesvirus Species 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000001415 gene therapy Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title 1
- 230000001717 pathogenic effect Effects 0.000 title 1
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000030741 antigen processing and presentation Effects 0.000 abstract 1
- 238000004690 coupled electron pair approximation Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9816781.0A GB9816781D0 (en) | 1998-07-31 | 1998-07-31 | Herpes virus vectors for dendritic cells |
| PCT/GB1999/002529 WO2000008191A2 (en) | 1998-07-31 | 1999-08-02 | Herpes virus vectors for dendritic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9912653A true BR9912653A (pt) | 2001-05-02 |
Family
ID=10836553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9912653-2A BR9912653A (pt) | 1998-07-31 | 1999-08-02 | Vìrus de herpes atenuado, cepa de vìrus, célula dendrìtica, processo para produzir um célula, composição farmacêutica, uso de um vìrus, e, processo para executar a terapia de gene em um paciente humano ou animal ou para tratar ou prevenir uma infecção patogênica ou câncer para tratar paciente animal |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6641817B1 (enExample) |
| EP (1) | EP1100942B1 (enExample) |
| JP (1) | JP4430824B2 (enExample) |
| KR (1) | KR100635246B1 (enExample) |
| CN (1) | CN1384884B (enExample) |
| AT (1) | ATE374829T1 (enExample) |
| AU (1) | AU765105B2 (enExample) |
| BR (1) | BR9912653A (enExample) |
| CA (1) | CA2337494C (enExample) |
| CY (1) | CY1107844T1 (enExample) |
| DE (1) | DE69937239T2 (enExample) |
| DK (1) | DK1100942T3 (enExample) |
| ES (1) | ES2294848T3 (enExample) |
| GB (2) | GB9816781D0 (enExample) |
| IL (1) | IL141126A0 (enExample) |
| PT (1) | PT1100942E (enExample) |
| WO (1) | WO2000008191A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
| CA2347067C (en) | 1998-03-31 | 2013-09-17 | Geron Corporation | Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer |
| GB0009079D0 (en) * | 2000-04-12 | 2000-05-31 | Neurovex Ltd | Herpes viruses for immune modulation |
| US6713067B2 (en) * | 1998-07-31 | 2004-03-30 | Biovex Limited | Herpes viruses for immune modulation |
| GB9816781D0 (en) * | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
| US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| US7223593B2 (en) * | 2000-01-21 | 2007-05-29 | Biovex Limited | Herpes virus strains for gene therapy |
| US7063851B2 (en) | 2000-04-12 | 2006-06-20 | Biovex Limited | Herpes viruses for immune modulation |
| JP2004529158A (ja) * | 2001-05-02 | 2004-09-24 | ラモツト・アツト・テル−アビブ・ユニバーシテイ・リミテツド | 混成殺腫瘍ヘルペスウイルスベクター |
| EP1387694A2 (en) * | 2001-05-09 | 2004-02-11 | M'S Science Corporation | Composition and method for treating cancer using herpes virus |
| GB0203285D0 (en) | 2002-02-12 | 2002-03-27 | Brown Susanne M | An herpes simplex virus complex |
| US8216564B2 (en) | 2002-05-02 | 2012-07-10 | Ramot At Tel-Aviv University Ltd. | Composite oncolytic herpes virus vectors |
| JP2004099584A (ja) * | 2002-05-02 | 2004-04-02 | Keio Gijuku | Ｈｓｖを用いた抗腫瘍剤 |
| CA2421269A1 (en) | 2002-08-09 | 2004-02-09 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| GB0317511D0 (en) * | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
| WO2007016239A2 (en) * | 2005-07-29 | 2007-02-08 | President And Fellows Of Harvard College | Herpes simplex virus mutant and uses therefore |
| KR100878017B1 (ko) * | 2007-04-09 | 2009-01-14 | 인제대학교 산학협력단 | 이종 유전자 발현을 위한 숙주균 및 그의 이용방법 |
| US9181315B2 (en) | 2009-01-08 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for induced brown fat differentiation |
| EP2408904B1 (en) | 2009-03-20 | 2017-10-18 | Mesoblast, Inc. | Production of reprogrammed pluripotent cells |
| AU2011207348A1 (en) | 2010-01-21 | 2012-08-02 | Dana-Farber Cancer Institute, Inc. | Context specific genetic screen platform to aid in gene discovery and target validation |
| US9539427B2 (en) | 2010-11-08 | 2017-01-10 | The Johns Hopkins University | Methods for improving heart function |
| US8969519B2 (en) | 2011-09-13 | 2015-03-03 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for brown fat induction and activity using FNDC5 |
| WO2013055911A1 (en) | 2011-10-14 | 2013-04-18 | Dana-Farber Cancer Institute, Inc. | Znf365/zfp365 biomarker predictive of anti-cancer response |
| CA2944903A1 (en) | 2014-04-24 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
| WO2016057367A1 (en) | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response |
| CA2963602A1 (en) | 2014-10-09 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Multiple-variable il-2 dose regimen for treating immune disorders |
| EP3265825A4 (en) | 2015-03-06 | 2018-08-08 | Dana-Farber Cancer Institute, Inc. | Pd-l2 biomarkers predictive of pd-1 pathway inhibitor responses in esophagogastric cancers |
| CN105219738A (zh) * | 2015-09-21 | 2016-01-06 | 北京神源德生物科技有限公司 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
| CN105219739A (zh) * | 2015-09-21 | 2016-01-06 | 北京神源德生物科技有限公司 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
| EP3362074B1 (en) | 2015-10-16 | 2023-08-09 | President and Fellows of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
| AU2016343978A1 (en) | 2015-10-29 | 2018-05-17 | Dana-Farber Cancer Institute, Inc. | Methods for identification, assessment, prevention, and treatment of metabolic disorders using PM20D1 and N-lipidated amino acids |
| JP2019512271A (ja) | 2016-03-21 | 2019-05-16 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｔ細胞疲弊状態特異的遺伝子発現調節因子およびその使用 |
| CA3034643A1 (en) | 2016-09-20 | 2018-03-29 | Ellen Weisberg | Compositions and methods for identification, assessment, prevention, and treatment of aml using usp10 biomarkers and modulators |
| US11820822B2 (en) | 2017-06-06 | 2023-11-21 | Dana-Farber Cancer Institute, Inc. | Methods for sensitizing cancer cells to T cell-mediated killing by modulating molecular pathways |
| EP3759125A4 (en) | 2018-02-28 | 2021-12-08 | Dana-Farber Cancer Institute, Inc. | CANCER TREATMENT METHODS USING COMBINATIONS OF ANTI-BTNL2 BLOCKING AGENTS AND IMMUNE CHECKPOINTS |
| CN111867637B (zh) * | 2018-03-19 | 2024-05-03 | 勃林格殷格翰动物保健有限公司 | 新ehv插入位点ul43 |
| WO2019204057A1 (en) | 2018-04-06 | 2019-10-24 | Dana-Farber Cancer Institute, Inc. | Kir3dl3 as an hhla2 receptor, anti-hhla2 antibodies, and uses thereof |
| WO2020223121A1 (en) | 2019-04-30 | 2020-11-05 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer using combinations of anti-cx3cr1 and immune checkpoint blockade agents |
| US20230075965A1 (en) | 2020-01-24 | 2023-03-09 | Constantine S. Mitsiades | Uses of biomarkers for improving immunotherapy |
| US20230374599A1 (en) | 2020-10-19 | 2023-11-23 | Alexander Gusev | Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy |
| WO2022104104A2 (en) | 2020-11-13 | 2022-05-19 | Dana-Farber Cancer Institute, Inc. | Personalized fusion cell vaccines |
| EP4288140A1 (en) | 2021-02-05 | 2023-12-13 | Iovance Biotherapeutics, Inc. | Adjuvant therapy for cancer |
| US20240280561A1 (en) | 2021-06-08 | 2024-08-22 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating and/or identifying an agent for treating intestinal cancers |
| US20250381241A1 (en) | 2021-11-29 | 2025-12-18 | Dana-Farber Cancer Institute, Inc. | Methods and compositions to modulate riok2 |
| WO2023158732A1 (en) | 2022-02-16 | 2023-08-24 | Dana-Farber Cancer Institute, Inc. | Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof |
| WO2025034542A1 (en) | 2023-08-04 | 2025-02-13 | Cornell University | Gene signature panel predicting cancer response to immune checkpoint blockade and radiation therapy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69332501T3 (de) * | 1992-07-31 | 2009-03-26 | The President And Fellows Of Harvard College, Cambridge | Herpesvirus impfstoffe |
| GB9615794D0 (en) | 1996-07-26 | 1996-09-04 | Medical Res Council | Mutant herpes simplex virus strains and uses thereof |
| US5998174A (en) | 1997-05-12 | 1999-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Multigene vectors |
| GB9816781D0 (en) * | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
| US6713067B2 (en) * | 1998-07-31 | 2004-03-30 | Biovex Limited | Herpes viruses for immune modulation |
| US7063851B2 (en) * | 2000-04-12 | 2006-06-20 | Biovex Limited | Herpes viruses for immune modulation |
-
1998
- 1998-07-31 GB GBGB9816781.0A patent/GB9816781D0/en not_active Ceased
-
1999
- 1999-08-02 AU AU51822/99A patent/AU765105B2/en not_active Expired
- 1999-08-02 JP JP2000563814A patent/JP4430824B2/ja not_active Expired - Lifetime
- 1999-08-02 DE DE69937239T patent/DE69937239T2/de not_active Expired - Lifetime
- 1999-08-02 GB GB0104400A patent/GB2361921B/en not_active Expired - Lifetime
- 1999-08-02 CA CA002337494A patent/CA2337494C/en not_active Expired - Lifetime
- 1999-08-02 CN CN99811376XA patent/CN1384884B/zh not_active Expired - Lifetime
- 1999-08-02 IL IL14112699A patent/IL141126A0/xx not_active IP Right Cessation
- 1999-08-02 BR BR9912653-2A patent/BR9912653A/pt not_active IP Right Cessation
- 1999-08-02 ES ES99936848T patent/ES2294848T3/es not_active Expired - Lifetime
- 1999-08-02 US US09/744,942 patent/US6641817B1/en not_active Expired - Lifetime
- 1999-08-02 PT PT99936848T patent/PT1100942E/pt unknown
- 1999-08-02 AT AT99936848T patent/ATE374829T1/de active
- 1999-08-02 EP EP99936848A patent/EP1100942B1/en not_active Expired - Lifetime
- 1999-08-02 KR KR1020017001361A patent/KR100635246B1/ko not_active Expired - Lifetime
- 1999-08-02 DK DK99936848T patent/DK1100942T3/da active
- 1999-08-02 WO PCT/GB1999/002529 patent/WO2000008191A2/en not_active Ceased
-
2005
- 2005-06-20 US US11/155,688 patent/US20050249707A1/en not_active Abandoned
-
2007
- 2007-12-27 CY CY20071101634T patent/CY1107844T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU765105B2 (en) | 2003-09-11 |
| JP2003502008A (ja) | 2003-01-21 |
| IL141126A0 (en) | 2002-02-10 |
| CN1384884A (zh) | 2002-12-11 |
| GB2361921A (en) | 2001-11-07 |
| CA2337494C (en) | 2009-06-23 |
| US6641817B1 (en) | 2003-11-04 |
| CY1107844T1 (el) | 2013-06-19 |
| DE69937239D1 (de) | 2007-11-15 |
| KR20010072162A (ko) | 2001-07-31 |
| GB9816781D0 (en) | 1998-09-30 |
| JP4430824B2 (ja) | 2010-03-10 |
| WO2000008191A3 (en) | 2000-06-08 |
| CN1384884B (zh) | 2010-12-08 |
| GB2361921B (en) | 2003-12-17 |
| CA2337494A1 (en) | 2000-02-17 |
| DE69937239T2 (de) | 2008-07-24 |
| DK1100942T3 (da) | 2008-02-04 |
| KR100635246B1 (ko) | 2006-10-19 |
| WO2000008191A2 (en) | 2000-02-17 |
| EP1100942A2 (en) | 2001-05-23 |
| ATE374829T1 (de) | 2007-10-15 |
| US20050249707A1 (en) | 2005-11-10 |
| AU5182299A (en) | 2000-02-28 |
| PT1100942E (pt) | 2007-12-06 |
| EP1100942B1 (en) | 2007-10-03 |
| HK1037925A1 (en) | 2002-02-22 |
| GB0104400D0 (en) | 2001-04-11 |
| ES2294848T3 (es) | 2008-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9912653A (pt) | Vìrus de herpes atenuado, cepa de vìrus, célula dendrìtica, processo para produzir um célula, composição farmacêutica, uso de um vìrus, e, processo para executar a terapia de gene em um paciente humano ou animal ou para tratar ou prevenir uma infecção patogênica ou câncer para tratar paciente animal | |
| EP1385466A4 (en) | ONCOLYTIC VIRUS THERAPY | |
| BRPI0412845A (pt) | herpes-vìrus, uso de um vìrus, composição farmacêutica, e, método de tratamento de um tumor em um indivìduo em necessidade do mesmo | |
| BR0111956A (pt) | Tratamento do vìrus do papiloma humano | |
| BR0012069A (pt) | Composições e métodos para a terapia e diagnóstico de câncer pulmonar | |
| CY1106152T1 (el) | Νεα ανοσογονα αντι-hiv (ανατοξινες), μεθοδοι παρασκευης και εφαρμογη στην προληψη και στην αγωγη του aids | |
| BR9808100A (pt) | Utilização de amandantina para tratamento de hepatite c. | |
| ATE296839T1 (de) | Antikörper zur krebsbehandlung und -diagnose | |
| BR0107737A (pt) | Vìrus da herpes, uso de um vìrus, composição farmacêutica, método para tratar um tumor em um indivìduo, agente para tratar câncer, e, cepa hsvi jsi | |
| BR9507506A (pt) | Processo para exterminar uma célula processo para tratamento de càncer composição e kit terapéutico | |
| ATE138384T1 (de) | Olionukleotidalkylphosphonate und - phosphonothioate | |
| BR9712366A (pt) | Gene de gd2 do vírus do herpes simples hsv2 isolado, plasmídeo compreendendo o mesmo, e, processos de induzir, em indivíduo, uma resposta imune contra hsv2 gd2, de tratar um indíviduo que está infectado com hsv, e, de prevenir que um indivíduo fique infectado com hsv | |
| BR0115794A (pt) | Métodos para introduzir uma molécula em uma célula, e para tratar ou prevenir uma doença, distúrbio ou infecção em um paciente por terapia gênica, célula, composição farmacêutica, e, uso de uma molécula de transferência associada com um veìculo viral e um agente fotossensibilizante ou de uma célula. | |
| ES2164914T3 (es) | Medicamentos de inmunoterapia que contienen anticuerpos que detectan especificamente el antigeno mhcii del paciente a tratar. | |
| DE60023300D1 (de) | Verwendung von cpg als adjuvans für hivimpstoff | |
| BR0109928A (pt) | Uso de um herpes vìrus atenuado, e, método para estimular uma resposta imune em um indivìduo humano ou animal, ou para tratar ou prevenir uma infecção patogênica ou câncer em um indivìduo humano ou animal | |
| AP9801286A0 (en) | Therapeutic compounds. | |
| TR200102024T2 (tr) | Yeni tedavi. | |
| PT1237562E (pt) | Processo de preparacao de extractos de micania contendo micanolida e di-hidromicanolida e utilizacao no tratamento das doencas proliferativas | |
| BR0111024A (pt) | Composições e métodos para a terapia e diagnóstico de câncer de mama | |
| AR005750A1 (es) | Composicion farmaceutica para tratar o prevenir infecciones con zoster en personas infectadas con el virus de varicela zoster y procedimiento para preparar dicha composicion | |
| BR9807332A (pt) | Antìgenos de leishmania para utilização na terapia e diagnóstico de leishmaniose | |
| PT859613E (pt) | Utilizacao de flupirtina para a profilaxia e o tratamento de doencas associadas a uma alteracao do sistema celular hematopoietico | |
| BR9910594A (pt) | Vìrus de herpes simplex, uso de um vìrus de herpessimplex, composição farmacêutica e processospara estudar a função de um gene heterólogo emuma célula de mamìfero, para produzir um vìrus deherpes simplex e para tratar um distúrbio ou uma lesãodo sistema nervoso de um mamìfero | |
| NZ512850A (en) | Treatment of papillomavirus infections |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: BIOVEX LIMITED (GB) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020060150520/RJ DE 29/09/2006. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07F | Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette] |
Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |