DE69931756T2 - Regionen variabler schwerer ketten und variabler leichter ketten von antikörpern für humanes blutplättchen-glykoprotein ib alpha - Google Patents

Regionen variabler schwerer ketten und variabler leichter ketten von antikörpern für humanes blutplättchen-glykoprotein ib alpha Download PDF

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Publication number
DE69931756T2
DE69931756T2 DE69931756T DE69931756T DE69931756T2 DE 69931756 T2 DE69931756 T2 DE 69931756T2 DE 69931756 T DE69931756 T DE 69931756T DE 69931756 T DE69931756 T DE 69931756T DE 69931756 T2 DE69931756 T2 DE 69931756T2
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Germany
Prior art keywords
antibody
platelets
human
alpha
variable
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69931756T
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German (de)
English (en)
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DE69931756D1 (de
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Jonathan L. Syracuse Miller
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Publication of DE69931756T2 publication Critical patent/DE69931756T2/de
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69931756T 1998-10-30 1999-10-29 Regionen variabler schwerer ketten und variabler leichter ketten von antikörpern für humanes blutplättchen-glykoprotein ib alpha Expired - Lifetime DE69931756T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10627598P 1998-10-30 1998-10-30
US106275P 1998-10-30
PCT/US1999/025495 WO2000026667A1 (en) 1998-10-30 1999-10-29 Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein ib alpha

Publications (2)

Publication Number Publication Date
DE69931756D1 DE69931756D1 (de) 2006-07-20
DE69931756T2 true DE69931756T2 (de) 2007-05-24

Family

ID=22310524

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69931756T Expired - Lifetime DE69931756T2 (de) 1998-10-30 1999-10-29 Regionen variabler schwerer ketten und variabler leichter ketten von antikörpern für humanes blutplättchen-glykoprotein ib alpha

Country Status (8)

Country Link
EP (1) EP1051620B1 (https=)
JP (1) JP2002529054A (https=)
AT (1) ATE329263T1 (https=)
AU (1) AU1458500A (https=)
CA (1) CA2317808A1 (https=)
DE (1) DE69931756T2 (https=)
IL (1) IL137121A0 (https=)
WO (1) WO2000026667A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9918788D0 (en) 1999-08-10 1999-10-13 Leuven K U Res & Dev Antithrombotic effect of platelet glycoprotein 1b blocking monoclonal Fab fragments
DE10019967A1 (de) * 2000-04-20 2001-10-25 Fenning Biomed Gmbh Dr Antikörper gegen natives gp96, deren Herstellung und Verwendung
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
AU2003256299A1 (en) 2002-07-01 2004-01-19 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
CA2491471A1 (en) * 2002-07-03 2004-01-15 The Trustees Of The University Of Pennsylvania Compositions, methods and kits relating to anti-platelet autoantibodies and inhibitors thereof
WO2004044584A1 (en) * 2002-11-13 2004-05-27 Micromet Ag Method for identifying antigen specific b cells
MXPA06000252A (es) * 2003-06-30 2006-12-15 Bio Technology General Israel Anticuerpos y usos de los mismos.
EP1749536A1 (en) * 2005-08-03 2007-02-07 Thrombotargets Europe, S.L. Activated factor X stimulants as new antihemorrhagic agents for topical use
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
DK2186829T3 (en) 2008-11-14 2015-04-07 Canadian Blood Services Antibodies to GPIbalfa
WO2011053763A2 (en) * 2009-10-30 2011-05-05 Centocor Ortho Biotech Inc. Il-17a antagonists
EP4073123A4 (en) * 2019-12-10 2024-01-10 CCOA Therapeutics Inc. HUMANIZED ANTIBODIES IB ALPHA (GPIBALPHA) ANTIBODIES
JP7822313B2 (ja) * 2019-12-20 2026-03-02 メディミューン，エルエルシー グリピカン３を標的とするキメラ抗原受容体を用いて癌を治療する組成物及び方法
KR20230027267A (ko) * 2020-06-23 2023-02-27 카드몬 코포레이션, 엘엘씨 항-pd-1 항체 및 융합 단백질

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877155A (en) * 1995-03-17 1999-03-02 The Research Foundation Of State University Of New York Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX
US5817748A (en) * 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX

Also Published As

Publication number Publication date
JP2002529054A (ja) 2002-09-10
WO2000026667A1 (en) 2000-05-11
DE69931756D1 (de) 2006-07-20
WO2000026667A9 (en) 2001-04-12
ATE329263T1 (de) 2006-06-15
EP1051620B1 (en) 2006-06-07
IL137121A0 (en) 2001-06-14
AU1458500A (en) 2000-05-22
EP1051620A1 (en) 2000-11-15
EP1051620A4 (en) 2005-01-12
CA2317808A1 (en) 2000-05-11

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