DE69929440T2 - Zusammensetzungen zur behandlung chronischer lymphatischer leukämie - Google Patents
Zusammensetzungen zur behandlung chronischer lymphatischer leukämie Download PDFInfo
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- DE69929440T2 DE69929440T2 DE69929440T DE69929440T DE69929440T2 DE 69929440 T2 DE69929440 T2 DE 69929440T2 DE 69929440 T DE69929440 T DE 69929440T DE 69929440 T DE69929440 T DE 69929440T DE 69929440 T2 DE69929440 T2 DE 69929440T2
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- Germany
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- alkyl
- hydrogen
- alkoxy
- indole
- Prior art date
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| US94878P | 1998-07-29 | ||
| PCT/US1999/015501 WO2000002555A1 (en) | 1998-07-09 | 1999-07-08 | Methods and compositions for the treatment of chronic lymphocytic leukemia |
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| DE69929440T2 true DE69929440T2 (de) | 2006-08-17 |
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| US7105560B1 (en) * | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
| US6545034B1 (en) | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
| US7151100B1 (en) | 1999-07-23 | 2006-12-19 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| US7361680B2 (en) | 1999-07-23 | 2008-04-22 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| US7129262B2 (en) | 1999-07-23 | 2006-10-31 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| WO2004026116A2 (en) | 2002-09-19 | 2004-04-01 | The Regents Of The University Of California | Use of etodoclac to treat hyperplasia |
| CA2540343A1 (en) * | 2003-10-02 | 2005-04-14 | Cephalon, Inc. | Indole derivatives |
| US7638331B2 (en) | 2004-01-02 | 2009-12-29 | The Administration of the Tulane Rducation Fund | Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery |
| MX2007005361A (es) * | 2004-11-05 | 2008-01-11 | Cephalon Inc | Tratamientos para cancer. |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| GEP20156300B (en) * | 2008-05-20 | 2015-06-25 | Incuron Llc | Inducing cell death by inhibiting adaptive heat shock response |
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| EP2605650A4 (en) | 2010-08-18 | 2014-05-21 | Del Mar Pharmaceuticals | COMPOSITIONS AND METHODS FOR INCREASING THE THERAPEUTIC UTILITY OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL AND DIACETYL DIANHYDROGALACTITOL |
| CA2863679A1 (en) | 2011-08-17 | 2014-05-30 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dibromodulcitol |
| CN110711188A (zh) | 2012-01-20 | 2020-01-21 | 德玛公司 | 经取代的己糖醇类用于治疗恶性肿瘤的用途 |
| US20150087687A1 (en) | 2012-03-23 | 2015-03-26 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
| US9814693B2 (en) | 2012-05-09 | 2017-11-14 | Delmar Pharmaceuticals, Inc. | Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies |
| AU2013280644B2 (en) | 2012-06-26 | 2018-08-02 | Jeffrey A. BACHA | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| WO2015154064A2 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| US10434086B2 (en) | 2014-04-06 | 2019-10-08 | Incuron, Inc. | Combination therapies with curaxins |
| CA3023049A1 (en) | 2016-05-04 | 2017-11-09 | Inmed Pharmaceuticals Inc. | Use of topical formulations of cannabinoids in the treatment of epidermolysis bullosa and related connective tissue disorders |
| WO2019056123A1 (en) | 2017-09-22 | 2019-03-28 | Inmed Pharmaceuticals Inc. | TOPICAL FORMULATIONS OF CANNABINOIDS AND THEIR USE IN THE TREATMENT OF PAIN |
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| WO1998019649A2 (en) * | 1996-11-05 | 1998-05-14 | The Children's Medical Center Corporation | Methods and compositions for inhibition of angiogenesis |
| US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
| DE69929440T2 (de) * | 1998-07-09 | 2006-08-17 | Cephalon, Inc. | Zusammensetzungen zur behandlung chronischer lymphatischer leukämie |
| US7105560B1 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
| US6545034B1 (en) * | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
| WO2002012188A2 (en) | 2000-08-09 | 2002-02-14 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
-
1999
- 1999-07-08 DE DE69929440T patent/DE69929440T2/de not_active Expired - Fee Related
- 1999-07-08 NZ NZ509376A patent/NZ509376A/en unknown
- 1999-07-08 DK DK99937222T patent/DK1104297T3/da active
- 1999-07-08 JP JP2000558815A patent/JP2002520282A/ja active Pending
- 1999-07-08 PT PT99937222T patent/PT1104297E/pt unknown
- 1999-07-08 US US09/720,992 patent/US6573292B1/en not_active Expired - Fee Related
- 1999-07-08 EP EP99937222A patent/EP1104297B8/en not_active Expired - Lifetime
- 1999-07-08 WO PCT/US1999/015501 patent/WO2000002555A1/en not_active Ceased
- 1999-07-08 ES ES99937222T patent/ES2255287T3/es not_active Expired - Lifetime
- 1999-07-08 CA CA002336932A patent/CA2336932A1/en not_active Abandoned
- 1999-07-08 AT AT99937222T patent/ATE315392T1/de not_active IP Right Cessation
- 1999-07-08 AU AU52098/99A patent/AU767586B2/en not_active Ceased
-
2003
- 2003-03-31 US US10/404,943 patent/US6921772B2/en not_active Expired - Fee Related
-
2005
- 2005-07-26 US US11/190,356 patent/US20050261356A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT1104297E (pt) | 2006-05-31 |
| AU767586B2 (en) | 2003-11-20 |
| AU5209899A (en) | 2000-02-01 |
| EP1104297A4 (en) | 2003-01-02 |
| DK1104297T3 (da) | 2006-05-29 |
| EP1104297A1 (en) | 2001-06-06 |
| NZ509376A (en) | 2003-10-31 |
| JP2002520282A (ja) | 2002-07-09 |
| ATE315392T1 (de) | 2006-02-15 |
| US6573292B1 (en) | 2003-06-03 |
| US20050261356A1 (en) | 2005-11-24 |
| WO2000002555A1 (en) | 2000-01-20 |
| US20030232874A1 (en) | 2003-12-18 |
| ES2255287T3 (es) | 2006-06-16 |
| US6921772B2 (en) | 2005-07-26 |
| CA2336932A1 (en) | 2000-01-20 |
| EP1104297B8 (en) | 2006-05-03 |
| DE69929440D1 (de) | 2006-04-06 |
| EP1104297B1 (en) | 2006-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: CEPHALON, INC., FRAZER, PA., US |
|
| 8381 | Inventor (new situation) |
Inventor name: NARDELLA, FRANCIS A., SCOTTSDALE, ARIZ., US |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |