DE69929440D1 - Zusammensetzungen zur behandlung chronischer lymphatischer leukämie - Google Patents
Zusammensetzungen zur behandlung chronischer lymphatischer leukämieInfo
- Publication number
- DE69929440D1 DE69929440D1 DE69929440T DE69929440T DE69929440D1 DE 69929440 D1 DE69929440 D1 DE 69929440D1 DE 69929440 T DE69929440 T DE 69929440T DE 69929440 T DE69929440 T DE 69929440T DE 69929440 D1 DE69929440 D1 DE 69929440D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- treatment
- lymphatic leukemia
- chronic lymphatic
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 title abstract 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 title 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 4
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 2
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical class C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001716 carbazoles Chemical class 0.000 abstract 1
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 abstract 1
- 229960005293 etodolac Drugs 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9246698P | 1998-07-09 | 1998-07-09 | |
US92466P | 1998-07-09 | ||
US9487898P | 1998-07-29 | 1998-07-29 | |
US94878P | 1998-07-29 | ||
PCT/US1999/015501 WO2000002555A1 (en) | 1998-07-09 | 1999-07-08 | Methods and compositions for the treatment of chronic lymphocytic leukemia |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69929440D1 true DE69929440D1 (de) | 2006-04-06 |
DE69929440T2 DE69929440T2 (de) | 2006-08-17 |
Family
ID=26785713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69929440T Expired - Fee Related DE69929440T2 (de) | 1998-07-09 | 1999-07-08 | Zusammensetzungen zur behandlung chronischer lymphatischer leukämie |
Country Status (12)
Country | Link |
---|---|
US (3) | US6573292B1 (de) |
EP (1) | EP1104297B8 (de) |
JP (1) | JP2002520282A (de) |
AT (1) | ATE315392T1 (de) |
AU (1) | AU767586B2 (de) |
CA (1) | CA2336932A1 (de) |
DE (1) | DE69929440T2 (de) |
DK (1) | DK1104297T3 (de) |
ES (1) | ES2255287T3 (de) |
NZ (1) | NZ509376A (de) |
PT (1) | PT1104297E (de) |
WO (1) | WO2000002555A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000002555A1 (en) * | 1998-07-09 | 2000-01-20 | Nardella Francis A | Methods and compositions for the treatment of chronic lymphocytic leukemia |
US7361680B2 (en) | 1999-07-23 | 2008-04-22 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7129262B2 (en) | 1999-07-23 | 2006-10-31 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7151100B1 (en) | 1999-07-23 | 2006-12-19 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US6545034B1 (en) | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
US7105560B1 (en) * | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
WO2004026116A2 (en) | 2002-09-19 | 2004-04-01 | The Regents Of The University Of California | Use of etodoclac to treat hyperplasia |
WO2005033112A2 (en) * | 2003-10-02 | 2005-04-14 | Cephalon, Inc. | Substituted indole derivatives |
US7638331B2 (en) | 2004-01-02 | 2009-12-29 | The Administration of the Tulane Rducation Fund | Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery |
EP1814544A4 (de) * | 2004-11-05 | 2009-12-02 | Cephalon Inc | Krebsbehandlungen |
US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
EA021331B1 (ru) * | 2008-05-20 | 2015-05-29 | Общество С Ограниченной Ответственностью "Инкурон" | Индуцирование клеточной гибели путем ингибирования адаптивной реакции теплового шока |
CA2735899A1 (en) * | 2008-09-25 | 2010-04-01 | Cephalon, Inc. | Liquid formulations of bendamustine |
MX2011007557A (es) * | 2009-01-15 | 2011-08-12 | Cephalon Inc | Formas nuevas de bendamustina como base libre. |
KR20140022750A (ko) | 2010-08-18 | 2014-02-25 | 델 마 파마슈티컬스 인코포레이티드 | 디안하이드로갈락티톨 및 디아세틸디안하이드로갈락티톨과 같은 치환된 헥시톨을 포함하는 준최적하게 투여되는 화학적 화합물의 치료상 이점을 향상시키기 위한 조성물 및 방법 |
EP3795145A3 (de) | 2011-08-17 | 2021-06-09 | Dennis M. Brown | Zusammensetzungen und verfahren zur erhöhung des therapeutischen nutzens von suboptimal verabreichten chemischen verbindungen einschliesslich substituierter hexitole wie dibromodulcitol |
BR112014017833A2 (pt) | 2012-01-20 | 2021-03-23 | Dennis Brown | Uso de hexitóis substituídos incluindo dianidrogalactitol e análogos para tratar doença neoplástica e células-tronco de câncer incluindo glioblastoma multiforme e meduloblastoma |
EP2827869A4 (de) | 2012-03-23 | 2015-09-23 | Dennis Brown | Zusammensetzungen und verfahren zur verbesserung des therapeutischen nutzens von indirubin und analoga davon, mit meisoindigo |
WO2013169600A1 (en) | 2012-05-09 | 2013-11-14 | Delmar Pharmaceuticals | Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies |
EP2872161B1 (de) | 2012-06-26 | 2020-12-16 | Del Mar Pharmaceuticals | Dianhydrogalactitol zur verwendung bei der behandlung von tyrosinkinaseinhibitor-resistenten malignomen bei patienten mit genetischen polymorphismen oder ahi1-dysregulierungen oder mutationen |
CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
EP3129022A4 (de) | 2014-04-06 | 2018-02-21 | Incuron, Llc | Kombinationstherapie mit curaxinen |
JP7054691B2 (ja) | 2016-05-04 | 2022-04-14 | インメド ファーマシューティカルズ インコーポレイティド | 表皮水疱症及び関連する結合組織疾患の治療におけるカンナビノイドの局所製剤の使用 |
Family Cites Families (42)
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DE1071897B (de) | 1957-12-19 | 1959-12-24 | ||
US3843480A (en) | 1963-08-28 | 1974-10-22 | D Dreher | Dry dry transfer |
US3948262A (en) | 1969-04-01 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US3993073A (en) | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
US3843681A (en) | 1971-06-01 | 1974-10-22 | American Home Prod | 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives |
US3939178A (en) | 1971-06-01 | 1976-02-17 | American Home Products Corporation | Certain pyrano [3,4-b]indoles and thiopyrano[3,4-b]indoles |
US3974179A (en) | 1971-06-01 | 1976-08-10 | American Home Products Corporation | 1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives |
US3948254A (en) | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US3839178A (en) * | 1972-10-05 | 1974-10-01 | Gen Electric | Potentiometric oxygen sensor |
US4310509A (en) | 1979-07-31 | 1982-01-12 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesive having a broad spectrum antimicrobial therein |
US4291015A (en) | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
JPS5777617A (en) | 1980-10-20 | 1982-05-15 | Nichiban Co Ltd | Plaster for cardiac disease |
IL61721A (en) | 1980-12-16 | 1984-03-30 | Blank Izhak | Nitroglycerin preparations |
US4542013A (en) | 1981-07-08 | 1985-09-17 | Key Pharmaceuticals, Inc. | Trinitroglycerol sustained release vehicles and preparation therefrom |
US4460562A (en) | 1982-01-06 | 1984-07-17 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing propranolol |
US4485097A (en) | 1982-05-26 | 1984-11-27 | Massachusetts Institute Of Technology | Bone-equivalent and method for preparation thereof |
US4542012A (en) | 1982-07-02 | 1985-09-17 | Minnesota Mining And Manufacturing Company | Film-forming composition containing an antimicrobial agent and methods |
US4608249A (en) | 1982-11-02 | 1986-08-26 | Nitto Electric Industrial Co., Ltd. | Hydrophilic therapeutic material |
IT1153909B (it) | 1982-12-17 | 1987-01-21 | Sogimi Srl | Polimeri reattivi per la cura di affezioni cutanee |
GB8317576D0 (en) | 1983-06-29 | 1983-08-03 | Shaw A S W | Consumer tobacco products |
US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
US4585877A (en) | 1985-05-06 | 1986-04-29 | American Home Products Corporation | Process for preparing 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)-indole-1-acetic acid, etodolac |
GB8514665D0 (en) | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
US4686213A (en) | 1986-08-15 | 1987-08-11 | American Home Products Corporation | Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids |
US4748252A (en) | 1986-08-15 | 1988-05-31 | American Home Products Corporation | Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids |
CA2131992A1 (en) | 1992-03-13 | 1993-09-16 | James W. Young | Antipyretic and analgesic methods and compositions containing optically pure r-etodolac |
US6160018A (en) | 1995-03-13 | 2000-12-12 | Loma Linda University Medical Center | Prophylactic composition and method for alzheimer's Disease |
US5955504A (en) | 1995-03-13 | 1999-09-21 | Loma Linda University Medical Center | Colorectal chemoprotective composition and method of preventing colorectal cancer |
US5981592A (en) * | 1995-03-13 | 1999-11-09 | Loma Linda University Medical Center | Method and composition for treating cystic fibrosis |
US5599946A (en) | 1995-05-30 | 1997-02-04 | Teva Pharmaceutical Industries Ltd. | 3-(2-trialkylsilyloxy)ethyl-7-ethyl-1H-indoles and method for their preparation |
MX9800568A (es) * | 1995-07-19 | 1998-04-30 | Merck & Co Inc | Uso de agentes anti-inflamatorios no esteroidales. |
US5968974A (en) | 1995-07-19 | 1999-10-19 | Merck & Co., Inc. | Method of treating colonic adenomas |
WO1997048391A2 (en) | 1996-06-21 | 1997-12-24 | Advanced Research And Technology Institute | Methods and compositions comprising r-ibuprofen |
US5776967A (en) | 1996-07-26 | 1998-07-07 | American Home Products Corporation | Pyranoindole inhibitors of COX--2 |
AU4043397A (en) * | 1996-07-26 | 1998-02-20 | American Home Products Corporation | Pyranoindole and carbazole inhibitors of cox-2 |
ATE305301T1 (de) * | 1996-11-05 | 2005-10-15 | Childrens Medical Center | Mittel zur hemmung von angiogenese enthaltend thalodomid und einen nsaid |
US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
WO2000002555A1 (en) * | 1998-07-09 | 2000-01-20 | Nardella Francis A | Methods and compositions for the treatment of chronic lymphocytic leukemia |
US6545034B1 (en) * | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
US7105560B1 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
CA2419060A1 (en) | 2000-08-09 | 2002-02-14 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
-
1999
- 1999-07-08 WO PCT/US1999/015501 patent/WO2000002555A1/en active IP Right Grant
- 1999-07-08 EP EP99937222A patent/EP1104297B8/de not_active Expired - Lifetime
- 1999-07-08 ES ES99937222T patent/ES2255287T3/es not_active Expired - Lifetime
- 1999-07-08 AT AT99937222T patent/ATE315392T1/de not_active IP Right Cessation
- 1999-07-08 NZ NZ509376A patent/NZ509376A/en unknown
- 1999-07-08 AU AU52098/99A patent/AU767586B2/en not_active Ceased
- 1999-07-08 DK DK99937222T patent/DK1104297T3/da active
- 1999-07-08 PT PT99937222T patent/PT1104297E/pt unknown
- 1999-07-08 CA CA002336932A patent/CA2336932A1/en not_active Abandoned
- 1999-07-08 JP JP2000558815A patent/JP2002520282A/ja active Pending
- 1999-07-08 DE DE69929440T patent/DE69929440T2/de not_active Expired - Fee Related
- 1999-07-08 US US09/720,992 patent/US6573292B1/en not_active Expired - Fee Related
-
2003
- 2003-03-31 US US10/404,943 patent/US6921772B2/en not_active Expired - Fee Related
-
2005
- 2005-07-26 US US11/190,356 patent/US20050261356A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ509376A (en) | 2003-10-31 |
AU5209899A (en) | 2000-02-01 |
ES2255287T3 (es) | 2006-06-16 |
ATE315392T1 (de) | 2006-02-15 |
DE69929440T2 (de) | 2006-08-17 |
DK1104297T3 (da) | 2006-05-29 |
EP1104297B1 (de) | 2006-01-11 |
EP1104297A1 (de) | 2001-06-06 |
EP1104297B8 (de) | 2006-05-03 |
US6573292B1 (en) | 2003-06-03 |
EP1104297A4 (de) | 2003-01-02 |
US20050261356A1 (en) | 2005-11-24 |
PT1104297E (pt) | 2006-05-31 |
AU767586B2 (en) | 2003-11-20 |
JP2002520282A (ja) | 2002-07-09 |
US20030232874A1 (en) | 2003-12-18 |
US6921772B2 (en) | 2005-07-26 |
WO2000002555A1 (en) | 2000-01-20 |
CA2336932A1 (en) | 2000-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: CEPHALON, INC., FRAZER, PA., US |
|
8381 | Inventor (new situation) |
Inventor name: NARDELLA, FRANCIS A., SCOTTSDALE, ARIZ., US |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |