BR112013003671A2 - composições e métodos para melhorar os benefícios terapêuticos de compostos químicos administyrados sub-otimamente incluindo hexitóis substituídos tais como dianidrogalactitol e diacetildianidrogalactiol - Google Patents
composições e métodos para melhorar os benefícios terapêuticos de compostos químicos administyrados sub-otimamente incluindo hexitóis substituídos tais como dianidrogalactitol e diacetildianidrogalactiolInfo
- Publication number
- BR112013003671A2 BR112013003671A2 BR112013003671A BR112013003671A BR112013003671A2 BR 112013003671 A2 BR112013003671 A2 BR 112013003671A2 BR 112013003671 A BR112013003671 A BR 112013003671A BR 112013003671 A BR112013003671 A BR 112013003671A BR 112013003671 A2 BR112013003671 A2 BR 112013003671A2
- Authority
- BR
- Brazil
- Prior art keywords
- anhydrogalactiol
- dianhydrogalactitol
- diacetyl
- compositions
- improving
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Abstract
abstract not avaible
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40170710P | 2010-08-18 | 2010-08-18 | |
US40170610P | 2010-08-18 | 2010-08-18 | |
US40171210P | 2010-08-18 | 2010-08-18 | |
US40170910P | 2010-08-18 | 2010-08-18 | |
US40170510P | 2010-08-18 | 2010-08-18 | |
PCT/US2011/048031 WO2012024367A2 (en) | 2010-08-18 | 2011-08-17 | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013003671A2 true BR112013003671A2 (pt) | 2017-01-10 |
Family
ID=45605648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013003671A BR112013003671A2 (pt) | 2010-08-18 | 2011-08-17 | composições e métodos para melhorar os benefícios terapêuticos de compostos químicos administyrados sub-otimamente incluindo hexitóis substituídos tais como dianidrogalactitol e diacetildianidrogalactiol |
Country Status (12)
Country | Link |
---|---|
US (1) | US9066918B2 (pt) |
EP (2) | EP2605650A4 (pt) |
JP (1) | JP2013537552A (pt) |
KR (1) | KR20140022750A (pt) |
CN (2) | CN103476250A (pt) |
AU (2) | AU2011292044A1 (pt) |
BR (1) | BR112013003671A2 (pt) |
CA (1) | CA2808626A1 (pt) |
CL (1) | CL2013000481A1 (pt) |
MX (1) | MX2013001858A (pt) |
SG (2) | SG188234A1 (pt) |
WO (1) | WO2012024367A2 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9085544B2 (en) | 2010-08-18 | 2015-07-21 | Del Mar Pharmaceuticals | Method of synthesis of substituted hexitols such as dianhydrogalactitol |
US9630938B2 (en) | 2010-08-18 | 2017-04-25 | Delmar Pharmaceuticals, Inc. | Method of synthesis of substituted hexitols such as dianhydrogalactitol |
US9901563B2 (en) * | 2013-03-11 | 2018-02-27 | Delmar Pharmaceuticals, Inc. | Compositions to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol |
EP2758043A4 (en) * | 2011-08-17 | 2016-02-24 | Dennis M Brown | COMPOSITIONS AND METHODS FOR INCREASING THE THERAPEUTIC UTILITY OF SUBOPTIMALLY APPLIED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIBROMODULCITOL |
CN115813902A (zh) * | 2012-01-20 | 2023-03-21 | 德玛公司 | 经取代的己糖醇类用于治疗恶性肿瘤的用途 |
CN102626412B (zh) * | 2012-03-23 | 2014-01-15 | 武汉大学 | 一种治疗恶性肿瘤的药物组合物 |
WO2013169600A1 (en) * | 2012-05-09 | 2013-11-14 | Delmar Pharmaceuticals | Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies |
MX367055B (es) * | 2012-06-26 | 2019-08-02 | Del Mar Pharmaceuticals | El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa. |
US8987469B2 (en) | 2012-07-24 | 2015-03-24 | Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg | Process for the preparation of bendamustine |
US11491154B2 (en) * | 2013-04-08 | 2022-11-08 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
WO2014179528A2 (en) * | 2013-05-01 | 2014-11-06 | Brown Dennis M | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted naphthalimides such as amonafide for the treatment of immunological, metabolic, infectious, and benign or neoplastic hyperproliferative disease conditions |
TW201536278A (zh) * | 2013-05-31 | 2015-10-01 | Del Mar Pharmaceuticals | 雙脫水半乳糖醇及其類似物與衍生物用於治療復發性惡性神經膠瘤或進行性繼發腦瘤之用途 |
KR20160104612A (ko) * | 2013-07-26 | 2016-09-05 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조성물 |
KR101561345B1 (ko) * | 2013-10-17 | 2015-10-16 | 대원제약주식회사 | 제어방출되는 프로피온산 계열의 약제학적 조성물 |
KR101511857B1 (ko) | 2013-11-01 | 2015-04-13 | 주식회사 엘지생활건강 | 디메틸 칸타리딘을 유효성분으로 포함하는 체모성장 저해용 조성물 |
MX2016013027A (es) | 2014-04-04 | 2017-05-23 | Del Mar Pharmaceuticals | Uso de dianhidrogalactitol y analogos o derivados del mismo para tratar cancer de celulas no pequeñas del pulmon y cancer de ovario. |
KR20170081261A (ko) * | 2014-11-10 | 2017-07-11 | 델 마 파마슈티컬스 인코포레이티드 | 방사선과 함께 폐의 비-소세포 암종 및 다형성 교아종을 치료하기 위한 디안하이드로갈락티톨 |
CN105031284A (zh) * | 2015-08-31 | 2015-11-11 | 王学宽 | 治疗口腔白斑病的口服药剂 |
CN105663060B (zh) * | 2016-02-23 | 2018-08-14 | 广西梧州制药(集团)股份有限公司 | 一种去水卫矛醇脂质体冻干粉针剂及其制备方法 |
CN105663072B (zh) * | 2016-02-23 | 2018-09-28 | 广西梧州制药(集团)股份有限公司 | 一种去水卫矛醇薄膜包衣片及其制备方法 |
CN105663076A (zh) * | 2016-02-23 | 2016-06-15 | 广西梧州制药(集团)股份有限公司 | 一种起效快防潮好的去水卫矛醇薄膜包衣片及其制备方法 |
CN107463784B (zh) * | 2017-08-16 | 2020-12-08 | 华东理工大学 | 一种苯乙烯设备选型规则生成方法 |
US11965206B2 (en) | 2018-12-21 | 2024-04-23 | John Stoddard | Method of dosing a patient with multiple drugs using adjusted phenotypes of CYP450 enzymes |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU172826B (hu) * | 1974-12-24 | 1978-12-28 | Mta Koezponti Kemiai Kutato In | Sposob poluchenija novykh acilnykh proizvodnykh 1,2-5,6-diangidro-geksitov s protivoopukholevoj aktivnost'ju |
HU182227B (en) * | 1980-11-04 | 1983-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing hexitols containing free carboxyl group |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US6011069A (en) | 1995-12-26 | 2000-01-04 | Nisshin Flour Milling Co., Ltd. | Multidrug resistance inhibitors |
US6057367A (en) * | 1996-08-30 | 2000-05-02 | Duke University | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses |
AU4543899A (en) | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
ES2255287T3 (es) | 1998-07-09 | 2006-06-16 | Cephalon, Inc. | Composiciones para el tratamiento de la leucemia linfocitica cronica. |
EP1160826A3 (en) | 2000-05-30 | 2006-12-13 | Ebara Corporation | Coating, modification and etching of substrate surface with particle beam irradiation |
US20020037328A1 (en) * | 2000-06-01 | 2002-03-28 | Brown Dennis M. | Hexitol compositions and uses thereof |
CN1116875C (zh) | 2000-10-19 | 2003-08-06 | 南京振中生物工程有限公司 | 紫杉醇脂质组合物及其制备方法 |
US7619005B2 (en) | 2000-11-01 | 2009-11-17 | Cognition Pharmaceuticals Llc | Methods for treating cognitive impairment in humans with Multiple Sclerosis |
DK1397155T3 (en) | 2001-06-21 | 2015-12-07 | Genentech Inc | Prolonged release formulation |
EP1585817B1 (en) | 2002-02-20 | 2009-09-02 | The General Hospital Corporation | Conjugates comprising a biodegradable polymer and uses therefor |
US7101576B2 (en) | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
US20070207952A1 (en) | 2003-03-24 | 2007-09-06 | Sequoia Pharmaceuticals | Long Acting Biologically Active Conjugates |
TW200524940A (en) | 2003-10-02 | 2005-08-01 | Salmedix Inc | Indole derivatives |
HUP0303313A2 (hu) | 2003-10-09 | 2005-07-28 | Richter Gedeon Vegyészeti Gyár Rt. | Transzdermális gyógyszerkészítmények |
UA82753C2 (uk) * | 2003-12-18 | 2008-05-12 | Цозер Б. Салама | Похідні проліну, що використовуються як фармацевтичні активні інгредієнти для лікування пухлин |
WO2006012213A2 (en) * | 2004-06-25 | 2006-02-02 | Tea Guard Llc | Composition and method for delivery of phytochemicals |
TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
US20090318561A1 (en) * | 2008-06-23 | 2009-12-24 | Mutual Pharmaceutical Company, Inc. | Colchicine products, method of manufacture, and methods of use |
-
2011
- 2011-08-17 AU AU2011292044A patent/AU2011292044A1/en not_active Abandoned
- 2011-08-17 MX MX2013001858A patent/MX2013001858A/es not_active Application Discontinuation
- 2011-08-17 CN CN2011800501692A patent/CN103476250A/zh active Pending
- 2011-08-17 KR KR1020137006881A patent/KR20140022750A/ko not_active Application Discontinuation
- 2011-08-17 EP EP11818706.1A patent/EP2605650A4/en not_active Ceased
- 2011-08-17 SG SG2013011937A patent/SG188234A1/en unknown
- 2011-08-17 EP EP17173607.7A patent/EP3246026A3/en not_active Withdrawn
- 2011-08-17 JP JP2013524950A patent/JP2013537552A/ja active Pending
- 2011-08-17 BR BR112013003671A patent/BR112013003671A2/pt not_active IP Right Cessation
- 2011-08-17 WO PCT/US2011/048031 patent/WO2012024367A2/en active Search and Examination
- 2011-08-17 CA CA2808626A patent/CA2808626A1/en not_active Abandoned
- 2011-08-17 US US13/817,096 patent/US9066918B2/en active Active
- 2011-08-17 SG SG10201802116RA patent/SG10201802116RA/en unknown
- 2011-08-17 CN CN201710574963.6A patent/CN107441493A/zh active Pending
-
2013
- 2013-02-18 CL CL2013000481A patent/CL2013000481A1/es unknown
-
2016
- 2016-09-14 AU AU2016228194A patent/AU2016228194A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2012024367A3 (en) | 2012-05-31 |
CL2013000481A1 (es) | 2013-11-22 |
CN107441493A (zh) | 2017-12-08 |
EP3246026A3 (en) | 2018-02-21 |
KR20140022750A (ko) | 2014-02-25 |
AU2011292044A1 (en) | 2013-04-04 |
MX2013001858A (es) | 2013-09-13 |
EP2605650A4 (en) | 2014-05-21 |
WO2012024367A2 (en) | 2012-02-23 |
SG10201802116RA (en) | 2018-04-27 |
JP2013537552A (ja) | 2013-10-03 |
CA2808626A1 (en) | 2012-02-23 |
AU2016228194A1 (en) | 2016-10-06 |
EP2605650A2 (en) | 2013-06-26 |
EP3246026A2 (en) | 2017-11-22 |
SG188234A1 (en) | 2013-04-30 |
US9066918B2 (en) | 2015-06-30 |
CN103476250A (zh) | 2013-12-25 |
US20130289107A1 (en) | 2013-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112013003671A2 (pt) | composições e métodos para melhorar os benefícios terapêuticos de compostos químicos administyrados sub-otimamente incluindo hexitóis substituídos tais como dianidrogalactitol e diacetildianidrogalactiol | |
ECSP22091792A (es) | Compuestos tricíclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroplastos | |
CL2017002650A1 (es) | Compuestos novedosos | |
CL2017002483A1 (es) | Compuestos heterocíclicos como inhibidores de lsd1 | |
CL2017000521A1 (es) | Inhibidores de desmetilasa-1 específica a lisina | |
CR20130045A (es) | Compuestos terapéuticos | |
DOP2014000062A (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
EA201291143A1 (ru) | Пиразолилхиназолиновые ингибиторы киназы | |
NZ719905A (en) | Bicyclic heterocycle compounds and their uses in therapy | |
CR20140106A (es) | Compuestos y composiciones como inhibidores de la quinasa c-kit | |
DOP2012000257A (es) | Derivados del acido 1-amino-2-ciclopropiletilboronico | |
CO6721019A2 (es) | Quinazolincarboxamida azetidinas | |
UA108101C2 (xx) | Похідні n3-заміщених n1-сульфоніл-5-фторпіримідинонів | |
BR112013025415A2 (pt) | métodos para aumentar eficácia de terapia de câncer de folr1 | |
SMT201400148B (it) | Inibitori di jak2 e loro uso per il trattamento del cancro e di malattie mieloproliferative | |
CR20130410A (es) | Compuestos y composiciones como inhibidores de la trk | |
GT200800202A (es) | Quinazolinas para la inhibicion de pdk1 | |
EA201300730A1 (ru) | Производные индазолилтриазола | |
CR20200276A (es) | Sulfamoilarilamidas y su uso como medicamentos para el tratamientos de la hepatitis b (divisional exp. 2015-0059) | |
HUE037600T2 (hu) | Vegyületek és készítmények paraziták által okozott fertõzések kezelésére | |
IL241264A0 (en) | Compounds and compositions for the treatment of parasitic diseases | |
GT201500069A (es) | Piridinonas bicìclicas novedosas | |
GT201400090A (es) | 2-tiopirimidinonas | |
CL2011000258A1 (es) | Compuestos derivados de fenilamino-isonicotinamida; inhibidores de mek; composicion farmaceutica y uso para el tratamiento de enfermedades hiperproliferativas tales como cancer e inflamacion. | |
BR112014030720A8 (pt) | composto, composição farmacêutica e usos de inibidores de fbx03 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2529 DE 25-06-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |