DE69927007D1 - Spisulosin-verbindungen mit antitumor-aktivität - Google Patents
Spisulosin-verbindungen mit antitumor-aktivitätInfo
- Publication number
- DE69927007D1 DE69927007D1 DE69927007T DE69927007T DE69927007D1 DE 69927007 D1 DE69927007 D1 DE 69927007D1 DE 69927007 T DE69927007 T DE 69927007T DE 69927007 T DE69927007 T DE 69927007T DE 69927007 D1 DE69927007 D1 DE 69927007D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- sphingenine
- antitumor activity
- cytotoxicity
- spisula polynyma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- YRYJJIXWWQLGGV-ZWKOTPCHSA-N 1-deoxysphinganine Chemical class CCCCCCCCCCCCCCC[C@@H](O)[C@H](C)N YRYJJIXWWQLGGV-ZWKOTPCHSA-N 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 abstract 2
- 241000237543 Spisula Species 0.000 abstract 2
- 230000003013 cytotoxicity Effects 0.000 abstract 2
- 231100000135 cytotoxicity Toxicity 0.000 abstract 2
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 abstract 1
- 241001529936 Murinae Species 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 208000003747 lymphoid leukemia Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Farming Of Fish And Shellfish (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/058,456 US6107520A (en) | 1997-04-15 | 1998-04-10 | Spisulosine compounds |
| US58456 | 1998-04-10 | ||
| PCT/GB1999/001091 WO1999052521A1 (en) | 1998-04-10 | 1999-04-09 | Spisulosine compounds having antitumour activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69927007D1 true DE69927007D1 (de) | 2005-10-06 |
| DE69927007T2 DE69927007T2 (de) | 2006-06-29 |
Family
ID=22016916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69927007T Expired - Fee Related DE69927007T2 (de) | 1998-04-10 | 1999-04-09 | Spisulosin-verbindungen mit antitumor-aktivität |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6107520A (de) |
| EP (1) | EP1069894B1 (de) |
| JP (1) | JP2002511410A (de) |
| KR (1) | KR100568964B1 (de) |
| CN (1) | CN1335770A (de) |
| AT (1) | ATE303139T1 (de) |
| AU (1) | AU763981B2 (de) |
| BG (1) | BG64970B1 (de) |
| BR (1) | BR9910120A (de) |
| CA (1) | CA2328126A1 (de) |
| DE (1) | DE69927007T2 (de) |
| DK (1) | DK1069894T3 (de) |
| ES (1) | ES2248995T3 (de) |
| HK (1) | HK1042048A1 (de) |
| HU (1) | HUP0105443A3 (de) |
| IL (1) | IL138886A0 (de) |
| MX (1) | MXPA00009930A (de) |
| NO (1) | NO20005052L (de) |
| PL (1) | PL343381A1 (de) |
| RU (1) | RU2225710C2 (de) |
| SK (1) | SK15082000A3 (de) |
| TR (1) | TR200002955T2 (de) |
| UA (1) | UA72208C2 (de) |
| WO (1) | WO1999052521A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306911B1 (en) * | 2000-02-07 | 2001-10-23 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted amino acids as neutral sphingomyelinase inhibitors |
| KR20020092958A (ko) * | 2000-02-16 | 2002-12-12 | 파르마 마르.에스.에이. | 항종양 활성을 가진 옥시- 및 아미노-치환된테트라하이드로푸릴 유도체 |
| AU2001262518B2 (en) * | 2000-06-06 | 2006-10-26 | Pharma Mar, S.A. | Antitumoral compounds |
| FR2811556B1 (fr) * | 2000-07-11 | 2002-09-06 | Oreal | Composition comprenant un precurseur de ceramides, utilisation pour ameliorer l'epiderme naturel ou reconstruit , equivalent de peau obtenu |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| WO2004064713A2 (en) * | 2003-01-20 | 2004-08-05 | Vib Vzw | The use of yop preoteins or rho gtpase inhibitors as caspase-1 inhibitors |
| CN100360515C (zh) * | 2004-04-09 | 2008-01-09 | 中国科学院上海药物研究所 | 抗肿瘤活性成份陵水醇、制备方法和用途 |
| WO2006034849A1 (en) * | 2004-09-27 | 2006-04-06 | Pharma Mar, S.A., Sociedad Unipersonal | Antitumoral pharmaceutical compositions comprising a spisulosine and a cyclodextrin |
| RU2010101416A (ru) * | 2007-06-19 | 2011-07-27 | Такеда Фармасьютикал Компани Лимитед (Jp) | Профилактическое/лекарственное средство от рака |
| CN102206163B (zh) * | 2011-05-06 | 2013-07-10 | 中国海洋大学 | 一种长链碱的分离制备方法 |
| WO2014118556A2 (en) * | 2013-01-31 | 2014-08-07 | Research Foundation Of The City University Of New York | Selective inhibitors and allosteric activators of sphingosine kinase |
| CN104758275A (zh) * | 2015-03-05 | 2015-07-08 | 青岛申达高新技术开发有限公司 | 一种治疗结肠癌的药物组合物及其应用 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| CN112063606A (zh) * | 2020-08-25 | 2020-12-11 | 山东省科学院生物研究所 | 一种快速提取贝类消化内源酶的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| US5190876A (en) * | 1988-12-27 | 1993-03-02 | Emory University | Method of modifying cellular differentiation and function and compositions therefor |
| CA2007507C (en) * | 1989-02-03 | 1998-05-19 | Yasuyuki Igarashi | Sphingosine and n-methyl-sphingosine as inhibitor of cell growth |
| US5583160A (en) * | 1989-02-03 | 1996-12-10 | The Biomembrane Institute | Methylsphingosine used to treat apoptosis |
| US5426228A (en) * | 1994-06-27 | 1995-06-20 | Koskinen; Ari | General method for preparation of sphingosine bases and their analogues |
| EP0821068A3 (de) * | 1996-03-29 | 1999-06-02 | Rohm And Haas Company | Sphingolipide and Verfahren dazu |
-
1998
- 1998-04-10 US US09/058,456 patent/US6107520A/en not_active Ceased
-
1999
- 1999-04-09 CA CA002328126A patent/CA2328126A1/en not_active Abandoned
- 1999-04-09 DK DK99915898T patent/DK1069894T3/da active
- 1999-04-09 AT AT99915898T patent/ATE303139T1/de not_active IP Right Cessation
- 1999-04-09 HU HU0105443A patent/HUP0105443A3/hu unknown
- 1999-04-09 RU RU2000128037/15A patent/RU2225710C2/ru not_active IP Right Cessation
- 1999-04-09 MX MXPA00009930A patent/MXPA00009930A/es active IP Right Grant
- 1999-04-09 IL IL13888699A patent/IL138886A0/xx unknown
- 1999-04-09 BR BR9910120-3A patent/BR9910120A/pt not_active Application Discontinuation
- 1999-04-09 AU AU34321/99A patent/AU763981B2/en not_active Ceased
- 1999-04-09 DE DE69927007T patent/DE69927007T2/de not_active Expired - Fee Related
- 1999-04-09 CN CN99807084A patent/CN1335770A/zh active Pending
- 1999-04-09 ES ES99915898T patent/ES2248995T3/es not_active Expired - Lifetime
- 1999-04-09 KR KR1020007011292A patent/KR100568964B1/ko not_active IP Right Cessation
- 1999-04-09 PL PL99343381A patent/PL343381A1/xx not_active IP Right Cessation
- 1999-04-09 SK SK1508-2000A patent/SK15082000A3/sk unknown
- 1999-04-09 EP EP99915898A patent/EP1069894B1/de not_active Expired - Lifetime
- 1999-04-09 WO PCT/GB1999/001091 patent/WO1999052521A1/en active IP Right Grant
- 1999-04-09 JP JP2000543131A patent/JP2002511410A/ja not_active Abandoned
- 1999-04-09 TR TR2000/02955T patent/TR200002955T2/xx unknown
- 1999-09-04 UA UA2000105675A patent/UA72208C2/uk unknown
-
2000
- 2000-10-06 NO NO20005052A patent/NO20005052L/no not_active Application Discontinuation
- 2000-11-09 BG BG104935A patent/BG64970B1/bg unknown
-
2002
- 2002-05-23 HK HK02103875.2A patent/HK1042048A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TR200002955T2 (tr) | 2001-01-22 |
| DK1069894T3 (da) | 2006-01-09 |
| KR20010074483A (ko) | 2001-08-04 |
| IL138886A0 (en) | 2001-11-25 |
| HUP0105443A3 (en) | 2005-07-28 |
| CA2328126A1 (en) | 1999-10-21 |
| KR100568964B1 (ko) | 2006-04-07 |
| DE69927007T2 (de) | 2006-06-29 |
| AU763981B2 (en) | 2003-08-07 |
| EP1069894A1 (de) | 2001-01-24 |
| BR9910120A (pt) | 2000-12-26 |
| NO20005052D0 (no) | 2000-10-06 |
| WO1999052521A1 (en) | 1999-10-21 |
| AU3432199A (en) | 1999-11-01 |
| SK15082000A3 (sk) | 2001-08-06 |
| BG104935A (en) | 2001-07-31 |
| EP1069894B1 (de) | 2005-08-31 |
| MXPA00009930A (es) | 2002-04-24 |
| HK1042048A1 (zh) | 2002-08-02 |
| US6107520A (en) | 2000-08-22 |
| UA72208C2 (en) | 2005-02-15 |
| BG64970B1 (bg) | 2006-11-30 |
| CN1335770A (zh) | 2002-02-13 |
| ES2248995T3 (es) | 2006-03-16 |
| NO20005052L (no) | 2000-12-07 |
| HUP0105443A1 (hu) | 2002-07-29 |
| JP2002511410A (ja) | 2002-04-16 |
| PL343381A1 (en) | 2001-08-13 |
| ATE303139T1 (de) | 2005-09-15 |
| RU2225710C2 (ru) | 2004-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |