DK1069894T3 - Spisulosinforbindelser med antitumoraktivitet - Google Patents

Spisulosinforbindelser med antitumoraktivitet

Info

Publication number
DK1069894T3
DK1069894T3 DK99915898T DK99915898T DK1069894T3 DK 1069894 T3 DK1069894 T3 DK 1069894T3 DK 99915898 T DK99915898 T DK 99915898T DK 99915898 T DK99915898 T DK 99915898T DK 1069894 T3 DK1069894 T3 DK 1069894T3
Authority
DK
Denmark
Prior art keywords
compounds
sphingenine
spisulosin
antitumor activity
cytotoxicity
Prior art date
Application number
DK99915898T
Other languages
Danish (da)
English (en)
Inventor
Kenneth Rinehart
Nancy Louise Fregeau
Robert Arthur Warwick
Jesus Avila
Gravalos Dolores Garcia
Glynn Thomas Faircloth
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Application granted granted Critical
Publication of DK1069894T3 publication Critical patent/DK1069894T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Fodder In General (AREA)
DK99915898T 1998-04-10 1999-04-09 Spisulosinforbindelser med antitumoraktivitet DK1069894T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/058,456 US6107520A (en) 1997-04-15 1998-04-10 Spisulosine compounds

Publications (1)

Publication Number Publication Date
DK1069894T3 true DK1069894T3 (da) 2006-01-09

Family

ID=22016916

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99915898T DK1069894T3 (da) 1998-04-10 1999-04-09 Spisulosinforbindelser med antitumoraktivitet

Country Status (24)

Country Link
US (1) US6107520A (de)
EP (1) EP1069894B1 (de)
JP (1) JP2002511410A (de)
KR (1) KR100568964B1 (de)
CN (1) CN1335770A (de)
AT (1) ATE303139T1 (de)
AU (1) AU763981B2 (de)
BG (1) BG64970B1 (de)
BR (1) BR9910120A (de)
CA (1) CA2328126A1 (de)
DE (1) DE69927007T2 (de)
DK (1) DK1069894T3 (de)
ES (1) ES2248995T3 (de)
HK (1) HK1042048A1 (de)
HU (1) HUP0105443A3 (de)
IL (1) IL138886A0 (de)
MX (1) MXPA00009930A (de)
NO (1) NO20005052L (de)
PL (1) PL343381A1 (de)
RU (1) RU2225710C2 (de)
SK (1) SK15082000A3 (de)
TR (1) TR200002955T2 (de)
UA (1) UA72208C2 (de)
WO (1) WO1999052521A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306911B1 (en) * 2000-02-07 2001-10-23 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as neutral sphingomyelinase inhibitors
MXPA02007995A (es) * 2000-02-16 2003-05-23 Ruffles Graham Keith Derivados de tetrahidrofurilo sustituidos por oxy y amino con actividad antitumoral.
WO2001094357A1 (en) * 2000-06-06 2001-12-13 Pharma Mar, S.A. Antitumoral compounds
FR2811556B1 (fr) * 2000-07-11 2002-09-06 Oreal Composition comprenant un precurseur de ceramides, utilisation pour ameliorer l'epiderme naturel ou reconstruit , equivalent de peau obtenu
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
WO2004064713A2 (en) * 2003-01-20 2004-08-05 Vib Vzw The use of yop preoteins or rho gtpase inhibitors as caspase-1 inhibitors
CN100360515C (zh) * 2004-04-09 2008-01-09 中国科学院上海药物研究所 抗肿瘤活性成份陵水醇、制备方法和用途
WO2006034849A1 (en) * 2004-09-27 2006-04-06 Pharma Mar, S.A., Sociedad Unipersonal Antitumoral pharmaceutical compositions comprising a spisulosine and a cyclodextrin
JPWO2008156153A1 (ja) * 2007-06-19 2010-08-26 武田薬品工業株式会社 癌の予防・治療剤
CN102206163B (zh) * 2011-05-06 2013-07-10 中国海洋大学 一种长链碱的分离制备方法
WO2014118556A2 (en) * 2013-01-31 2014-08-07 Research Foundation Of The City University Of New York Selective inhibitors and allosteric activators of sphingosine kinase
CN104758275A (zh) * 2015-03-05 2015-07-08 青岛申达高新技术开发有限公司 一种治疗结肠癌的药物组合物及其应用
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
CN112063606A (zh) * 2020-08-25 2020-12-11 山东省科学院生物研究所 一种快速提取贝类消化内源酶的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU325756A1 (ru) * 1966-12-19 1983-01-15 Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе Лекарственный препарат
SU677293A1 (ru) * 1977-12-07 1992-04-23 Ленинградский Технологический Институт Им.Ленсовета Актиноцил-бис-( @ -диметиламинопропил)-амин, обладающий противоопухолевой активностью
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
US5190876A (en) * 1988-12-27 1993-03-02 Emory University Method of modifying cellular differentiation and function and compositions therefor
CA2007507C (en) * 1989-02-03 1998-05-19 Yasuyuki Igarashi Sphingosine and n-methyl-sphingosine as inhibitor of cell growth
US5583160A (en) * 1989-02-03 1996-12-10 The Biomembrane Institute Methylsphingosine used to treat apoptosis
US5426228A (en) * 1994-06-27 1995-06-20 Koskinen; Ari General method for preparation of sphingosine bases and their analogues
EP0821068A3 (de) * 1996-03-29 1999-06-02 Rohm And Haas Company Sphingolipide and Verfahren dazu

Also Published As

Publication number Publication date
RU2225710C2 (ru) 2004-03-20
PL343381A1 (en) 2001-08-13
ES2248995T3 (es) 2006-03-16
AU3432199A (en) 1999-11-01
KR20010074483A (ko) 2001-08-04
AU763981B2 (en) 2003-08-07
NO20005052L (no) 2000-12-07
WO1999052521A1 (en) 1999-10-21
BR9910120A (pt) 2000-12-26
US6107520A (en) 2000-08-22
IL138886A0 (en) 2001-11-25
HK1042048A1 (zh) 2002-08-02
DE69927007D1 (de) 2005-10-06
TR200002955T2 (tr) 2001-01-22
HUP0105443A3 (en) 2005-07-28
DE69927007T2 (de) 2006-06-29
HUP0105443A1 (hu) 2002-07-29
CA2328126A1 (en) 1999-10-21
ATE303139T1 (de) 2005-09-15
UA72208C2 (en) 2005-02-15
MXPA00009930A (es) 2002-04-24
BG64970B1 (bg) 2006-11-30
EP1069894B1 (de) 2005-08-31
JP2002511410A (ja) 2002-04-16
NO20005052D0 (no) 2000-10-06
EP1069894A1 (de) 2001-01-24
SK15082000A3 (sk) 2001-08-06
KR100568964B1 (ko) 2006-04-07
CN1335770A (zh) 2002-02-13
BG104935A (en) 2001-07-31

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