DE69918105D1 - Orale zubereitung enthaltend einen biguanid und eine organische säure - Google Patents

Orale zubereitung enthaltend einen biguanid und eine organische säure

Info

Publication number
DE69918105D1
DE69918105D1 DE69918105T DE69918105T DE69918105D1 DE 69918105 D1 DE69918105 D1 DE 69918105D1 DE 69918105 T DE69918105 T DE 69918105T DE 69918105 T DE69918105 T DE 69918105T DE 69918105 D1 DE69918105 D1 DE 69918105D1
Authority
DE
Germany
Prior art keywords
biguanide
organic acid
preparation containing
oral preparation
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69918105T
Other languages
English (en)
Other versions
DE69918105T2 (de
Inventor
Hiroyuki Nishii
Hirohisa Kobayashi
Kazuya Otoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Publication of DE69918105D1 publication Critical patent/DE69918105D1/de
Application granted granted Critical
Publication of DE69918105T2 publication Critical patent/DE69918105T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69918105T 1998-04-29 1999-04-26 Orale zubereitung enthaltend einen biguanid und eine organische säure Expired - Lifetime DE69918105T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13612698 1998-04-29
JP13612698 1998-04-29
PCT/JP1999/002192 WO1999055320A1 (en) 1998-04-29 1999-04-26 Oral formulation comprising biguanide and an organic acid

Publications (2)

Publication Number Publication Date
DE69918105D1 true DE69918105D1 (de) 2004-07-22
DE69918105T2 DE69918105T2 (de) 2005-07-07

Family

ID=15167924

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69918105T Expired - Lifetime DE69918105T2 (de) 1998-04-29 1999-04-26 Orale zubereitung enthaltend einen biguanid und eine organische säure

Country Status (11)

Country Link
US (1) US6517870B1 (de)
EP (1) EP1082109B1 (de)
JP (2) JP4606582B2 (de)
AT (1) ATE269069T1 (de)
AU (1) AU3536299A (de)
CA (1) CA2330485C (de)
DE (1) DE69918105T2 (de)
DK (1) DK1082109T3 (de)
ES (1) ES2224634T3 (de)
PT (1) PT1082109E (de)
WO (1) WO1999055320A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL365135A1 (en) * 2000-08-07 2004-12-27 Ranbaxy Signature Llc Liquid formulation of metformin
JP4706096B2 (ja) * 2000-10-23 2011-06-22 大正製薬株式会社 不快な味を呈する塩基性薬物配合製剤
FR2818906B1 (fr) * 2000-12-29 2004-04-02 Dospharma Association medicamenteuse d'une biguanine et d'un transporteur, par exemple de metformine et d'arginine
FR2818908B1 (fr) * 2000-12-29 2004-04-02 Dospharma Utilisation en tant que medicament d'un compose restituant in vivo des principes actifs
CA2434693A1 (en) 2001-01-18 2002-10-17 Genzyme Corporation Ionene polymers and their use as antimicrobial agents
US7220312B2 (en) * 2002-03-13 2007-05-22 Micron Technology, Inc. Methods for treating semiconductor substrates
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en) 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
FR2858556B1 (fr) * 2003-08-06 2006-03-10 Galenix Innovations Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
EP1674088A4 (de) * 2003-10-17 2009-04-15 Medrx Co Ltd Gel-präparat mit bioguanid-medikament
JP2005139173A (ja) * 2003-10-17 2005-06-02 Medorekkusu:Kk ビグアナイド系薬剤を含有するゼリー製剤
KR20060126688A (ko) * 2003-12-09 2006-12-08 다이닛본 스미토모 세이야꾸 가부시끼가이샤 약물-함유 입자 및 그 입자를 함유하는 고형 제제
DE10360924A1 (de) * 2003-12-23 2005-07-28 IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH Metformin-haltige pharmazeutische Zusammensetzung
JP4814636B2 (ja) * 2004-01-29 2011-11-16 大日本住友製薬株式会社 ビグアナイド系薬物の内服製剤
EP1568369A1 (de) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen
DE102005006539A1 (de) * 2005-02-11 2006-08-24 Merck Patent Gmbh Biguanid enthaltende Zusammensetzungen
UY29445A1 (es) * 2005-03-30 2006-10-02 Generex Pharm Inc Composiciones para la transmisión transmucosa oral de la metformina
CN101198319B (zh) * 2005-04-26 2012-08-01 大日本住友制药株式会社 含有双胍化合物的颗粒制剂
EP1942877A4 (de) * 2005-11-02 2011-09-14 Teikoku Pharma Usa Inc Organoleptisch annehmbare orale dosierformen von ibuprofen, herstellungsverfahren und anwendung
US20080107787A1 (en) * 2006-11-02 2008-05-08 The Coca-Cola Company Anti-Diabetic Composition with High-Potency Sweetener
WO2008097861A2 (en) * 2007-02-02 2008-08-14 Braincells, Inc. MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS
BRPI0809430A2 (pt) * 2007-07-23 2014-09-09 Teikoku Pharma Usa Inc Formulações de dosagem oral, organolepticamente aceitáveis, de um agonista indol do receptor de cerotonina e métodos de utilização das mesmas
JP2009067790A (ja) * 2007-08-21 2009-04-02 Nihon Generic Co Ltd エカベトナトリウムの不快な味をマスキングしてなるゼリー状製剤
JP5292404B2 (ja) * 2007-09-21 2013-09-18 ハンオル バイオファーマ カンパニー，リミテッド Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
WO2011154975A2 (en) 2010-06-08 2011-12-15 Cadila Healthcare Limited Pharmaceutical compositions of metformin
US9339543B2 (en) 2011-10-12 2016-05-17 Merck Sharp & Dohme Corp. Pharmaceutical compositions that inhibit disproportionation
AR088372A1 (es) * 2011-10-19 2014-05-28 Otsuka Pharma Co Ltd Solucion para administracion oral
US9382187B2 (en) 2012-07-10 2016-07-05 Thetis Pharmaceuticals Llc Tri-salt form of metformin
US8765811B2 (en) 2012-07-10 2014-07-01 Thetis Pharmaceuticals Llc Tri-salt form of metformin
WO2015171516A1 (en) 2014-05-05 2015-11-12 Thetis Pharmaceuticals Llc Compositions and methods relating to ionic salts of peptides
US9242008B2 (en) 2014-06-18 2016-01-26 Thetis Pharmaceuticals Llc Mineral amino-acid complexes of fatty acids
CN107074884A (zh) 2014-06-18 2017-08-18 西蒂斯制药有限责任公司 活性剂的矿物质氨基酸复合物
KR102437682B1 (ko) 2016-06-03 2022-08-29 테티스 파마수티컬스 엘엘씨 특화된 사전 해소 매개체의 염에 관한 조성물 및 방법

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB539076A (en) 1940-03-18 1941-08-27 Mergenthaler Setzmaschfab Gmbh Improvements in or relating to typographical composing machines
DE2124256A1 (en) 1971-05-15 1972-11-30 Dr Christian Brunnengraber Chemi sehe Fabrik & Co mbH 2400 Lübeck Oral antidiabetics - contg dicarboxylic amino acids
JPS5840529B2 (ja) * 1975-09-29 1983-09-06 明治製菓株式会社 ケイコウヨウセイザイノセイホウ
US4089957A (en) 1976-06-11 1978-05-16 Ab Kabi Therapeutic compositions against recurrent thrombosis
US5324748A (en) 1981-07-14 1994-06-28 Efamol Limited Method for enhancement of 1-series PG production
JPS60246325A (ja) 1984-05-18 1985-12-06 Takeda Chem Ind Ltd 苦味が軽減された苦味成分含有水性溶液
FR2611500B1 (fr) * 1987-03-06 1990-05-04 Lipha Emploi de derives du biguanide dans la preparation de medicaments
JP2643260B2 (ja) 1988-03-22 1997-08-20 藤沢薬品工業株式会社 シロップ剤
US4975465A (en) 1989-03-28 1990-12-04 American Home Products Corporation Orally administrable ibuprofen compositions
US5260275A (en) 1990-08-14 1993-11-09 Amylin Pharmaceuticals, Inc. Hypoglycemics
US5411755A (en) * 1993-02-16 1995-05-02 The Procter & Gamble Company Process and composition for sweet juice from cucurbitaceae fruit
JP2705787B2 (ja) 1994-09-30 1998-01-28 山之内製薬株式会社 苦味改善易服用性ｈ▲２▼ブロッカー固形製剤
JP3294033B2 (ja) * 1994-12-24 2002-06-17 俊博 森田 オブラート
JPH104939A (ja) * 1996-06-27 1998-01-13 Nippon Shinyaku Co Ltd 飲 料
JPH1036252A (ja) 1996-07-22 1998-02-10 Taisho Pharmaceut Co Ltd ベラドンナ（総）アルカロイド配合内服液剤
JP3658878B2 (ja) * 1996-08-05 2005-06-08 大正製薬株式会社 内服液剤
US6399658B1 (en) 1996-12-24 2002-06-04 Sumitomo Pharmaceuticals Co., Ltd. Composition containing ascorbic acid
CA2312990C (en) * 1997-12-08 2008-04-29 Bristol-Myers Squibb Company Novel salts of metformin and method

Also Published As

Publication number Publication date
EP1082109A1 (de) 2001-03-14
CA2330485C (en) 2008-07-08
JP5255604B2 (ja) 2013-08-07
JP2010195839A (ja) 2010-09-09
EP1082109B1 (de) 2004-06-16
ATE269069T1 (de) 2004-07-15
JP2002512953A (ja) 2002-05-08
DK1082109T3 (da) 2004-08-09
PT1082109E (pt) 2004-10-29
JP4606582B2 (ja) 2011-01-05
WO1999055320A1 (en) 1999-11-04
ES2224634T3 (es) 2005-03-01
DE69918105T2 (de) 2005-07-07
US6517870B1 (en) 2003-02-11
AU3536299A (en) 1999-11-16
CA2330485A1 (en) 1999-11-04

Similar Documents

Publication Publication Date Title
ATE269069T1 (de) Orale zubereitung enthaltend einen biguanid und eine organische säure
FR2807322B1 (fr) Composition, notamment cosmetique, comprenant de l'acide ascorbique en association avec un derive d'acide ascorbique
RU2002109792A (ru) Ароматические азотсодержащие 6-членные циклические соединения
DE60016670D1 (de) Kosmetisches Mittel enthaltend mindestens einen Hydroxystilben und Ascorbinsäure
BR0307924A (pt) N-aril-2-oxazolidinona-5-carboxamidas e seus derivados
IL144026A0 (en) Phenylphenanthridine derivatives and pharmaceutical compostions containing the same
BR0014526B1 (pt) compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo
ATE219889T1 (de) Elektrolyt-angereicherte keimlinge enthaltendes kombinationspräparat
DK1273299T3 (da) Minoxidilinindeholdende praparater
BR0212386A (pt) Composto, formulação farmacêutica, e, uso de um composto
DE60045402D1 (de) Silylalkylplatin (IV) Verbindungen und deren Herstellung
ES2180319T3 (es) Utilizacion de derivados de metilenbisoxazolidina y composiciones de los mismos.
DE60117523D1 (de) Orale zubereitung chlorhexidin und maltitol oder erythritol oder deren mischung enthaltend
BR0210160A (pt) Composições de fragâncias e flavorizantes
ATE339201T1 (de) Lasofoxifen enthaltende zusammensetzungen
DE60005462D1 (de) Tintenzusammensetzungen enthaltend 1,3,5-Trioxan
EP0616800A3 (de) Rieckstoffmittel mit verlängerter Diffusion.
ATE422531T1 (de) Organische verbindungen
ATE209485T1 (de) Kombinationspräparat enthaltend tramadol und einen calcium-kanal antagonisten
NO923266D0 (no) Heksahydrobenzo(f)quinolinoner
HRP20000703B1 (hr) Stabilni pripravci koji sadrže levosimendan i alginsku kiselinu
NO20021429L (no) 1,4-dioksacykloalkan-2-oner og 1,4-dioksacykloalken-2-oner
NO20041878D0 (no) Karboksylsyrederivat-forbindelser og legemidler inneholdende de samme som den aktive bestanddel.
ATE465989T1 (de) 13-substituierte methacyclinverbindungen
DE50102156D1 (de) N-heteroarylmethyl-p-phenylendiamin-derivate sowie diese verbindungen enthaltende oxidationsfärbemittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD., OSAKA, JP