|
US6403597B1
(en)
*
|
1997-10-28 |
2002-06-11 |
Vivus, Inc. |
Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
|
|
AU2001241142B2
(en)
*
|
2000-04-28 |
2005-09-22 |
Tanabe Seiyaku Co., Ltd. |
Cyclic compounds
|
|
US7273868B2
(en)
*
|
2000-04-28 |
2007-09-25 |
Tanabe Seiyaku Co., Ltd. |
Pyrazine derivatives
|
|
US20080027037A1
(en)
*
|
2000-04-28 |
2008-01-31 |
Tanabe Seiyaku Co., Ltd. |
Cyclic compounds
|
|
NZ524572A
(en)
*
|
2000-09-06 |
2004-08-27 |
Tanabe Seiyaku Co |
Oral compositions comprising phosphodiesterase inhibitors ( PDE inhibitor )and an acidic substance such as fumaric acid with improved drug efficacy due to decrease solubility in neutral and alkaline regions
|
|
AU9458401A
(en)
*
|
2000-09-20 |
2002-04-02 |
Ortho Mcneil Pharm Inc |
Pyrazine derivatives as modulators of tyrosine kinases
|
|
US20030134836A1
(en)
|
2001-01-12 |
2003-07-17 |
Amgen Inc. |
Substituted arylamine derivatives and methods of use
|
|
US20020147198A1
(en)
*
|
2001-01-12 |
2002-10-10 |
Guoqing Chen |
Substituted arylamine derivatives and methods of use
|
|
US6878714B2
(en)
|
2001-01-12 |
2005-04-12 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
KR100750554B1
(ko)
|
2001-02-15 |
2007-08-20 |
다나베 세이야꾸 가부시키가이샤 |
구강 내 속붕괴성 정제
|
|
AR036375A1
(es)
*
|
2001-08-30 |
2004-09-01 |
Novartis Ag |
Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos
|
|
EP1453516A2
(de)
|
2001-10-17 |
2004-09-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
|
|
ATE407678T1
(de)
*
|
2001-10-17 |
2008-09-15 |
Boehringer Ingelheim Pharma |
Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
|
|
EP1321463B1
(en)
*
|
2001-12-21 |
2007-08-08 |
Virochem Pharma Inc. |
Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections
|
|
WO2003062225A1
(en)
*
|
2002-01-23 |
2003-07-31 |
Bayer Pharmaceuticals Corporation |
Pyrimidine derivatives as rho-kinase inhibitors
|
|
US7176310B1
(en)
*
|
2002-04-09 |
2007-02-13 |
Ucb Sa |
Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
|
|
CA2485148A1
(en)
*
|
2002-05-09 |
2003-11-20 |
Cytokinetics, Inc. |
Pyrimidinone compounds, compositions and methods
|
|
US7057042B2
(en)
|
2002-05-29 |
2006-06-06 |
Abbott Laboratories |
Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
|
|
WO2003101994A1
(en)
*
|
2002-05-29 |
2003-12-11 |
Abbott Laboratories |
Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
|
|
WO2004014365A1
(en)
*
|
2002-08-13 |
2004-02-19 |
Warner-Lambert Company Llc |
Phthalimide derivatives as matrix metalloproteinase inhibitors
|
|
ATE440827T1
(de)
|
2002-12-04 |
2009-09-15 |
Ore Pharmaceuticals Inc |
Melanocortin-rezeptormodulatoren
|
|
GB0409744D0
(en)
*
|
2004-04-30 |
2004-06-09 |
Pfizer Ltd |
Novel compounds
|
|
CA2564994A1
(en)
*
|
2004-04-30 |
2005-11-10 |
Warner-Lambert Company Llc |
Substituted morpholine compounds for the treatment of central nervous system disorders
|
|
GB0425758D0
(en)
|
2004-11-23 |
2004-12-22 |
Vectura Ltd |
Preparation of pharmaceutical compositions
|
|
CN101163476A
(zh)
|
2005-04-19 |
2008-04-16 |
尼科梅德有限责任公司 |
用于治疗肺动脉高血压的罗氟司特
|
|
CA2620333A1
(en)
|
2005-08-26 |
2007-03-01 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
EP2258359A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation with sabcomelin
|
|
US8247556B2
(en)
|
2005-10-21 |
2012-08-21 |
Amgen Inc. |
Method for preparing 6-substituted-7-aza-indoles
|
|
EP2377530A3
(en)
|
2005-10-21 |
2012-06-20 |
Braincells, Inc. |
Modulation of neurogenesis by PDE inhibition
|
|
WO2007053596A1
(en)
|
2005-10-31 |
2007-05-10 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
JP2009536669A
(ja)
|
2006-05-09 |
2009-10-15 |
ブレインセルス，インコーポレイティド |
アンジオテンシン調節による神経新生
|
|
US20080051413A1
(en)
*
|
2006-08-25 |
2008-02-28 |
Kaohsiung Medical University |
Nitrophenylpiperazine derivative of xanthine which relaxes tracheal airway and increases respiratory performance
|
|
JP2010502670A
(ja)
|
2006-09-07 |
2010-01-28 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
真性糖尿病のための組合せ治療
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
TW200827346A
(en)
|
2006-11-03 |
2008-07-01 |
Astrazeneca Ab |
Chemical compounds
|
|
TW200836719A
(en)
|
2007-02-12 |
2008-09-16 |
Astrazeneca Ab |
Chemical compounds
|
|
TW200914457A
(en)
*
|
2007-05-31 |
2009-04-01 |
Kyowa Hakko Kogyo Kk |
Pyrimidodiazepinone derivative
|
|
MX2009013354A
(es)
|
2007-06-04 |
2010-07-06 |
Univ Ben Gurion |
Compuestos de triarilo y composiciones que los contienen.
|
|
US8071557B2
(en)
|
2007-06-13 |
2011-12-06 |
Vivus, Inc. |
Treatment of pulmonary hypertension with carbonic anhydrase inhibitors
|
|
WO2009013286A1
(en)
*
|
2007-07-24 |
2009-01-29 |
Novartis Ag |
Organic compounds
|
|
US8329691B2
(en)
*
|
2007-10-15 |
2012-12-11 |
Takeda Pharmaceutical Company Limited |
Amide compounds and use of the same
|
|
EP2082766A1
(en)
|
2008-01-24 |
2009-07-29 |
Vectura Delivery Devices Limited |
Blister Strip Coil Forming
|
|
EP2082771A1
(en)
|
2008-01-24 |
2009-07-29 |
Vectura Delivery Devices Limited |
Inhaler
|
|
EP2082767A1
(en)
|
2008-01-24 |
2009-07-29 |
Vectura Delivery Devices Limited |
Inhaler
|
|
EP2082772A1
(en)
|
2008-01-24 |
2009-07-29 |
Vectura Delivery Devices Limited |
Inhaler
|
|
EP2082768A1
(en)
|
2008-01-24 |
2009-07-29 |
Vectura Delivery Devices Limited |
Inhaler
|
|
AU2009225869B2
(en)
*
|
2008-03-18 |
2014-01-23 |
Merck Sharp & Dohme Llc |
Substituted 4-hydroxypyrimidine-5-carboxamides
|
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
CN102458402B
(zh)
|
2009-06-12 |
2013-10-02 |
百时美施贵宝公司 |
用作激酶调节剂的烟酰胺化合物
|
|
US8354593B2
(en)
*
|
2009-07-10 |
2013-01-15 |
Nanocomp Technologies, Inc. |
Hybrid conductors and method of making same
|
|
GB0921481D0
(en)
|
2009-12-08 |
2010-01-20 |
Vectura Ltd |
Process and product
|
|
EP2361911A1
(en)
*
|
2010-02-18 |
2011-08-31 |
GenKyoTex SA |
Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
|
|
EP2361912A1
(en)
*
|
2010-02-18 |
2011-08-31 |
GenKyoTex SA |
Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
|
|
WO2011126250A2
(ko)
|
2010-04-05 |
2011-10-13 |
에스케이케미칼 주식회사 |
Pde5 억제제를 함유하는 피부 주름 개선용 조성물
|
|
CN101798301A
(zh)
*
|
2010-04-13 |
2010-08-11 |
漆又毛 |
吡咯烷基嘧啶甲磺酰胺衍生物及制备方法
|
|
TW201210584A
(en)
|
2010-08-18 |
2012-03-16 |
Alcon Res Ltd |
Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma
|
|
CN102372697A
(zh)
*
|
2010-08-19 |
2012-03-14 |
山东轩竹医药科技有限公司 |
取代的嘧啶类化合物
|
|
JP5697800B2
(ja)
*
|
2011-07-21 |
2015-04-08 |
シュエンジュウ・ファーマ・カンパニー・リミテッド |
複素環置換ピリミジン化合物
|
|
US9402877B2
(en)
|
2011-11-04 |
2016-08-02 |
Xion Pharmaceuticals Corporation |
Methods and compositions for oral administration of melanocortin receptor agonist compounds
|
|
US20150119399A1
(en)
|
2012-01-10 |
2015-04-30 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
WO2014026467A1
(zh)
|
2012-08-14 |
2014-02-20 |
山东轩竹医药科技有限公司 |
双环取代的嘧啶类化合物
|
|
AU2013351550A1
(en)
|
2012-11-28 |
2015-07-16 |
Grünenthal GmbH |
Specific carboxamides as KCNQ2/3 modulators
|
|
MX2015006688A
(es)
*
|
2012-11-28 |
2015-08-10 |
Grünenthal GmbH |
Amino-arilcarboxamidas sustituidas como moduladores de kcnq2/3.
|
|
US9248122B2
(en)
|
2012-11-28 |
2016-02-02 |
Grünenthal GmbH |
Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
|
|
CN104059025B
(zh)
*
|
2013-03-20 |
2017-07-04 |
广州朗圣药业有限公司 |
一种用于制备阿伐那非的中间体及其制备方法
|
|
KR101749314B1
(ko)
|
2013-03-29 |
2017-07-03 |
수안주 파마 코포레이션 리미티드 |
비사이클릭-치환된 피리미딘 타입 pde-5 억제제의 프로드러그
|
|
WO2014174529A2
(en)
*
|
2013-04-23 |
2014-10-30 |
Hetero Research Foundation |
Polymorphs of avanafil
|
|
CN103254179B
(zh)
*
|
2013-05-23 |
2014-09-10 |
苏州明锐医药科技有限公司 |
阿伐那非的制备方法
|
|
CN103254180B
(zh)
*
|
2013-05-23 |
2014-07-23 |
苏州明锐医药科技有限公司 |
一种阿伐那非的制备方法
|
|
CN103265534B
(zh)
*
|
2013-05-23 |
2014-07-23 |
苏州明锐医药科技有限公司 |
阿伐那非的制备方法
|
|
WO2014187273A1
(zh)
*
|
2013-05-23 |
2014-11-27 |
苏州明锐医药科技有限公司 |
阿伐那非的制备方法
|
|
WO2015001567A1
(en)
*
|
2013-07-01 |
2015-01-08 |
Msn Laboratories Private Limited |
Process for the preparation of (s)-4-[(3-chloro-4-methoxybenzyl)amino]-2-[2- (hydroxymethyl)-1-pyrrolidinyl]-n-(2-pyrimidinyl methyl-5-pyrimidine carboxamide
|
|
CN104557877B
(zh)
*
|
2013-10-28 |
2016-08-17 |
重庆安格龙翔医药科技有限公司 |
一种阿伐那非中间体及其制备方法和应用
|
|
CA2928725A1
(en)
|
2013-11-05 |
2015-05-14 |
Esther Priel |
Compounds for the treatment of diabetes and disease complications arising from same
|
|
CN104628708A
(zh)
*
|
2013-11-13 |
2015-05-20 |
北大方正集团有限公司 |
一种阿伐那非的晶型及其制备方法、用途和药物组合物
|
|
CN104628707A
(zh)
*
|
2013-11-13 |
2015-05-20 |
北大方正集团有限公司 |
一种阿伐那非的无定型及其制备方法、用途和药物组合物
|
|
CN104650045B
(zh)
*
|
2013-11-19 |
2017-04-19 |
苏州旺山旺水生物医药有限公司 |
阿伐那非的制备方法
|
|
GB201321748D0
(en)
*
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
CN103833736A
(zh)
*
|
2014-03-04 |
2014-06-04 |
北京澳合药物研究院有限公司 |
一种阿伐那非的制备方法
|
|
WO2015177807A1
(en)
*
|
2014-05-22 |
2015-11-26 |
Wanbury Ltd. |
A process for the preparation of avanafil and its novel intermediates
|
|
CN104003981A
(zh)
*
|
2014-05-28 |
2014-08-27 |
河北康泰药业有限公司 |
阿伐那非的合成方法
|
|
CN104151299B
(zh)
*
|
2014-08-22 |
2017-03-08 |
北京科莱博医药开发有限责任公司 |
化合物、晶型化合物及其制备方法
|
|
CN104356115B
(zh)
*
|
2014-11-21 |
2016-08-24 |
齐鲁天和惠世制药有限公司 |
一种4-[(3-氯-4-甲氧基苄基)氨基]-2-[2-(羟甲基)-1-吡咯烷基]嘧啶-5-羧酸乙酯的制备方法
|
|
CN104530015B
(zh)
*
|
2014-12-10 |
2017-01-04 |
齐鲁天和惠世制药有限公司 |
一种阿伐那非的制备方法
|
|
WO2017168174A1
(en)
|
2016-04-02 |
2017-10-05 |
N4 Pharma Uk Limited |
New pharmaceutical forms of sildenafil
|
|
CN105924402A
(zh)
*
|
2016-05-06 |
2016-09-07 |
蚌埠中实化学技术有限公司 |
一种2-胺基甲基嘧啶盐酸盐的制备方法
|
|
SG11201811161YA
(en)
|
2016-07-14 |
2019-01-30 |
Pfizer |
Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
|
|
CN106496201A
(zh)
*
|
2016-10-31 |
2017-03-15 |
昆药集团股份有限公司 |
一种阿伐那非原料药的制备方法
|
|
WO2018112258A1
(en)
|
2016-12-14 |
2018-06-21 |
Respira Therapeutics, Inc. |
Methods and compositions for treatment of pulmonary hypertension and other lung disorders
|
|
CN107879986A
(zh)
*
|
2017-12-20 |
2018-04-06 |
重庆英斯凯化工有限公司 |
一种阿伐那非杂质的合成方法
|
|
CN108658872B
(zh)
*
|
2018-05-03 |
2021-06-22 |
无锡富泽药业有限公司 |
一种阿伐那非中间体的制备方法
|
|
AU2019319004A1
(en)
|
2018-08-06 |
2021-03-25 |
Nicox S.A. |
Nitric oxide releasing phosphodiesterase type 5 inhibitor
|
|
CN109280049B
(zh)
*
|
2018-09-25 |
2021-02-02 |
重庆奥舍生物化工有限公司 |
一种医药化合物阿伐那非的合成方法
|
|
CN109776505B
(zh)
*
|
2019-03-14 |
2021-07-27 |
扬州市三药制药有限公司 |
一种阿伐那非的制备方法
|
|
CN110078713B
(zh)
*
|
2019-04-10 |
2021-06-04 |
北京精华耀邦医药科技有限公司 |
一种用于治疗男性勃起功能障碍的化合物
|
|
CN110117274A
(zh)
*
|
2019-05-08 |
2019-08-13 |
梯尔希（南京）药物研发有限公司 |
一种阿伐那非杂质的制备方法
|
