JPS5481299A - Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative - Google Patents
Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivativeInfo
- Publication number
- JPS5481299A JPS5481299A JP14723377A JP14723377A JPS5481299A JP S5481299 A JPS5481299 A JP S5481299A JP 14723377 A JP14723377 A JP 14723377A JP 14723377 A JP14723377 A JP 14723377A JP S5481299 A JPS5481299 A JP S5481299A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- disubstituted
- alkyl group
- formula
- pyrimidine derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 N,N-disubstituted formamide Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- NHLLQCBSWYJLRI-UHFFFAOYSA-N pyrido[3,2-d]pyrimidine-2-carboxylic acid Chemical compound N1=CC=CC2=NC(C(=O)O)=NC=C21 NHLLQCBSWYJLRI-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Abstract
PURPOSE: To prepare the title compound useful as an intermediate for synthesis of pyridopyrimidine carboxylic aic derivatives having improved antibacterial actions, by reacting a novel pyrimidine derivative with a N,N-disubstituted formamide and phosphorus trichloride.
CONSTITUTION: A novel pyromidine derivative of formula II: [R1 is lower alkyl group; R2 is -S-R3 (R3 is lower alkyl group) or- NR'R" (R' and R" are the same or different lower alkyl group)], derived form a compound of formula I, is reacted with a N,N-disubstituted formamide of formula III: (R4 is lower alkyl group; R5 is lower alkyl or phenyl group) and phosphorus trichloride to form a 2,8-disubstituted-6-formyl-5,8-dihydro-5-oxopyrido [2,3-d] pyrimidine derivative of formula IV.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14723377A JPS5481299A (en) | 1977-12-09 | 1977-12-09 | Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14723377A JPS5481299A (en) | 1977-12-09 | 1977-12-09 | Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5481299A true JPS5481299A (en) | 1979-06-28 |
JPS5620314B2 JPS5620314B2 (en) | 1981-05-13 |
Family
ID=15425573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14723377A Granted JPS5481299A (en) | 1977-12-09 | 1977-12-09 | Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5481299A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1219609A4 (en) * | 1999-09-16 | 2002-11-06 | Tanabe Seiyaku Co | Aromatic nitrogenous six-membered ring compounds |
EP1277741A4 (en) * | 2000-04-28 | 2003-05-07 | Tanabe Seiyaku Co | Cyclic compounds |
US7078522B2 (en) | 2001-02-26 | 2006-07-18 | Tanabe Seiyaku Co., Ltd. | Pyridopyrimidine or naphthyridine derivative |
US7273868B2 (en) | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
-
1977
- 1977-12-09 JP JP14723377A patent/JPS5481299A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1219609A4 (en) * | 1999-09-16 | 2002-11-06 | Tanabe Seiyaku Co | Aromatic nitrogenous six-membered ring compounds |
US6656935B2 (en) | 1999-09-16 | 2003-12-02 | Tanabe Seiyaku Co., Ltd. | Aromatic nitrogen-containing 6-membered cyclic compounds |
US6797709B2 (en) | 1999-09-16 | 2004-09-28 | Tanabe Seiyaku Co., Ltd. | Aromatic nitrogen-containing 6-membered cyclic compounds |
EP1277741A4 (en) * | 2000-04-28 | 2003-05-07 | Tanabe Seiyaku Co | Cyclic compounds |
US7220736B2 (en) | 2000-04-28 | 2007-05-22 | Tanabe Seiyaku Co., Ltd. | Pyrimidine compounds |
US7273868B2 (en) | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
US7078522B2 (en) | 2001-02-26 | 2006-07-18 | Tanabe Seiyaku Co., Ltd. | Pyridopyrimidine or naphthyridine derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS5620314B2 (en) | 1981-05-13 |
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