JPS5481299A - Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative - Google Patents

Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative

Info

Publication number
JPS5481299A
JPS5481299A JP14723377A JP14723377A JPS5481299A JP S5481299 A JPS5481299 A JP S5481299A JP 14723377 A JP14723377 A JP 14723377A JP 14723377 A JP14723377 A JP 14723377A JP S5481299 A JPS5481299 A JP S5481299A
Authority
JP
Japan
Prior art keywords
lower alkyl
disubstituted
alkyl group
formula
pyrimidine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14723377A
Other languages
Japanese (ja)
Other versions
JPS5620314B2 (en
Inventor
Takumi Matsumura
Hiroshi Kawahara
Yoshitaka Wakita
Tatsuyuki Naritomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daito Koeki KK
Teijin Ltd
Original Assignee
Daito Koeki KK
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daito Koeki KK, Teijin Ltd filed Critical Daito Koeki KK
Priority to JP14723377A priority Critical patent/JPS5481299A/en
Publication of JPS5481299A publication Critical patent/JPS5481299A/en
Publication of JPS5620314B2 publication Critical patent/JPS5620314B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound useful as an intermediate for synthesis of pyridopyrimidine carboxylic aic derivatives having improved antibacterial actions, by reacting a novel pyrimidine derivative with a N,N-disubstituted formamide and phosphorus trichloride.
CONSTITUTION: A novel pyromidine derivative of formula II: [R1 is lower alkyl group; R2 is -S-R3 (R3 is lower alkyl group) or- NR'R" (R' and R" are the same or different lower alkyl group)], derived form a compound of formula I, is reacted with a N,N-disubstituted formamide of formula III: (R4 is lower alkyl group; R5 is lower alkyl or phenyl group) and phosphorus trichloride to form a 2,8-disubstituted-6-formyl-5,8-dihydro-5-oxopyrido [2,3-d] pyrimidine derivative of formula IV.
COPYRIGHT: (C)1979,JPO&Japio
JP14723377A 1977-12-09 1977-12-09 Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative Granted JPS5481299A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14723377A JPS5481299A (en) 1977-12-09 1977-12-09 Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14723377A JPS5481299A (en) 1977-12-09 1977-12-09 Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative

Publications (2)

Publication Number Publication Date
JPS5481299A true JPS5481299A (en) 1979-06-28
JPS5620314B2 JPS5620314B2 (en) 1981-05-13

Family

ID=15425573

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14723377A Granted JPS5481299A (en) 1977-12-09 1977-12-09 Preparation of 2,8-disubstituted-6-formyl-5,8-dihydro-5- oxopyrido 2,3-d pyrimidine derivative

Country Status (1)

Country Link
JP (1) JPS5481299A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1219609A4 (en) * 1999-09-16 2002-11-06 Tanabe Seiyaku Co Aromatic nitrogenous six-membered ring compounds
EP1277741A4 (en) * 2000-04-28 2003-05-07 Tanabe Seiyaku Co Cyclic compounds
US7078522B2 (en) 2001-02-26 2006-07-18 Tanabe Seiyaku Co., Ltd. Pyridopyrimidine or naphthyridine derivative
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1219609A4 (en) * 1999-09-16 2002-11-06 Tanabe Seiyaku Co Aromatic nitrogenous six-membered ring compounds
US6656935B2 (en) 1999-09-16 2003-12-02 Tanabe Seiyaku Co., Ltd. Aromatic nitrogen-containing 6-membered cyclic compounds
US6797709B2 (en) 1999-09-16 2004-09-28 Tanabe Seiyaku Co., Ltd. Aromatic nitrogen-containing 6-membered cyclic compounds
EP1277741A4 (en) * 2000-04-28 2003-05-07 Tanabe Seiyaku Co Cyclic compounds
US7220736B2 (en) 2000-04-28 2007-05-22 Tanabe Seiyaku Co., Ltd. Pyrimidine compounds
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
US7078522B2 (en) 2001-02-26 2006-07-18 Tanabe Seiyaku Co., Ltd. Pyridopyrimidine or naphthyridine derivative

Also Published As

Publication number Publication date
JPS5620314B2 (en) 1981-05-13

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