DE69912479T2 - 4- und 5-alkynyloxindole sowie 4- und 5-alkenyloxindole - Google Patents

4- und 5-alkynyloxindole sowie 4- und 5-alkenyloxindole Download PDF

Info

Publication number
DE69912479T2
DE69912479T2 DE69912479T DE69912479T DE69912479T2 DE 69912479 T2 DE69912479 T2 DE 69912479T2 DE 69912479 T DE69912479 T DE 69912479T DE 69912479 T DE69912479 T DE 69912479T DE 69912479 T2 DE69912479 T2 DE 69912479T2
Authority
DE
Germany
Prior art keywords
dihydro
methylene
radical
pyrrol
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69912479T
Other languages
German (de)
English (en)
Other versions
DE69912479D1 (de
Inventor
Kin-Chun Luk
E. Paige MAHANEY
Steven Gregory Mischke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69912479D1 publication Critical patent/DE69912479D1/de
Publication of DE69912479T2 publication Critical patent/DE69912479T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69912479T 1998-12-17 1999-12-07 4- und 5-alkynyloxindole sowie 4- und 5-alkenyloxindole Expired - Fee Related DE69912479T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11258998P 1998-12-17 1998-12-17
US112589P 1998-12-17
US14148299P 1999-06-29 1999-06-29
US141482P 1999-06-29
PCT/EP1999/009578 WO2000035906A2 (en) 1998-12-17 1999-12-07 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles

Publications (2)

Publication Number Publication Date
DE69912479D1 DE69912479D1 (de) 2003-12-04
DE69912479T2 true DE69912479T2 (de) 2004-07-22

Family

ID=26810125

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69912479T Expired - Fee Related DE69912479T2 (de) 1998-12-17 1999-12-07 4- und 5-alkynyloxindole sowie 4- und 5-alkenyloxindole

Country Status (14)

Country Link
EP (1) EP1149092B1 (enExample)
JP (1) JP2002532490A (enExample)
KR (1) KR20010087421A (enExample)
CN (1) CN1147486C (enExample)
AT (1) ATE253062T1 (enExample)
AU (1) AU771599B2 (enExample)
BR (1) BR9916272A (enExample)
CA (1) CA2354510A1 (enExample)
DE (1) DE69912479T2 (enExample)
DK (1) DK1149092T3 (enExample)
ES (1) ES2209527T3 (enExample)
PT (1) PT1149092E (enExample)
TR (1) TR200101747T2 (enExample)
WO (1) WO2000035906A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
MY128449A (en) 2000-05-24 2007-02-28 Sugen Inc Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2003535847A (ja) 2000-06-02 2003-12-02 スージェン・インコーポレーテッド 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体
WO2002002551A1 (en) * 2000-06-30 2002-01-10 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
WO2002083648A1 (fr) 2001-04-16 2002-10-24 Eisai Co., Ltd. Nouveau compose a base de 1h-indazole
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
WO2002096361A2 (en) 2001-05-30 2002-12-05 Sugen, Inc. 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
WO2003010164A1 (en) 2001-07-23 2003-02-06 Applied Research Systems Ars Holding N.V. Arylsulfonamide derivatives as c-jun-n-terminal kinases (jnk's) inhibitors
MXPA04002537A (es) 2001-10-12 2004-05-31 Warner Lambert Co Alquinos como inhibidores de metaloproteinasa de matriz.
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
US7390797B2 (en) 2002-02-28 2008-06-24 Eisai Co., Ltd. Fused indazole compounds
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
CN1656079A (zh) 2002-05-31 2005-08-17 卫材株式会社 吡唑化合物和含有该化合物的药物组合物
US7465736B2 (en) 2002-06-14 2008-12-16 Laboratoires Serono S.A. Azole methylidene cyanide derivatives and their use as protein kinase modulators
MXPA06004438A (es) 2003-10-24 2006-06-20 Schering Ag Derivados de indolinona y su uso en el tratamiento de enfermedades como el cancer.
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
US7803824B2 (en) 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
WO2006090698A1 (ja) * 2005-02-22 2006-08-31 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
CN1939922B (zh) * 2005-09-27 2010-10-13 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物
WO2007040208A1 (ja) 2005-10-03 2007-04-12 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその医薬用途
FR2962729B1 (fr) 2010-07-13 2012-09-21 Arkema France Molecules porteuses de groupes associatifs
FR2962733B1 (fr) 2010-07-13 2012-08-17 Michelin Soc Tech Polymere greffe par des molecules associatives azotees.
US20140205537A1 (en) * 2011-06-24 2014-07-24 Zenobia Therapeutics, Inc. Lrrk2 inhibitors
JP7270590B2 (ja) 2019-11-27 2023-05-10 財團法人工業技術研究院 自己発電式検出送信装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9610964D0 (en) * 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
EP0929520B1 (en) * 1996-08-23 2005-11-02 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
CA2289102A1 (en) * 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity

Also Published As

Publication number Publication date
BR9916272A (pt) 2001-09-04
WO2000035906A3 (en) 2000-11-09
PT1149092E (pt) 2004-03-31
CA2354510A1 (en) 2000-06-22
EP1149092B1 (en) 2003-10-29
ES2209527T3 (es) 2004-06-16
AU1507600A (en) 2000-07-03
KR20010087421A (ko) 2001-09-15
WO2000035906A2 (en) 2000-06-22
CN1331689A (zh) 2002-01-16
DE69912479D1 (de) 2003-12-04
TR200101747T2 (tr) 2001-11-21
AU771599B2 (en) 2004-03-25
ATE253062T1 (de) 2003-11-15
JP2002532490A (ja) 2002-10-02
CN1147486C (zh) 2004-04-28
DK1149092T3 (da) 2004-02-23
EP1149092A2 (en) 2001-10-31

Similar Documents

Publication Publication Date Title
EP1149092B1 (en) 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles
US6307056B1 (en) 4-aryloxindoles
DE69411939T2 (de) Kondensierte pyrrolcarboxanilide; eine neue klasse von gaba-gehirn-rezeptor-liganden
DE69634664T2 (de) Heterocyclische carbonsäurederivate und diese enthaltende arzneimittel
DE69512797T2 (de) Prostaglandin-synthase hemmer
DE69922526T2 (de) 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3)
DE60107857T2 (de) 3-Indolyl-4-Phenyl-1H-Pyrrol-2,5-Dion-Derivate als Glycogen Synthase-Kinase 3Beta Inhibitoren
DE60014893T2 (de) Pyrazolobenzodiazepine mit cdk2 hemmender wirkung
DE69901969T2 (de) Benzimidazole Derivate als Cyclooxygenase-2 Inhibitoren
DE69919361T2 (de) Pyridyl-ether und -thioether als nikotin-acetylcholin-rezeptorliganden und ihre therapeutische anwendung
DE60203263T2 (de) Pyrazolderivate gegen tgf überexprimierung
DE69906152T2 (de) 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2
JP2000509719A (ja) 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
CN110337433B (zh) 用于调节sgk活性的化合物和药物组合物及其方法
US6221867B1 (en) 4,5-pyrazinoxindoles
EP0126401A1 (de) Neue Indolverbindungen
DE10219294A1 (de) Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel
JP2015531392A (ja) Ｍｇｌｕｒ５受容体活性のモジュレーターとしてのエチニル誘導体
DE10237883A1 (de) Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
US6313310B1 (en) 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
KR20010114267A (ko) 치환된 3-피리딜-4-아릴피롤과 관련 치료방법 및 예방방법
DE60107852T2 (de) Thienopyrrolidinone
DE60216279T2 (de) Alkyliden- pirazolidindion derivate und deren verwendung gegen diabetes und obesitas
DD235867A5 (de) Verfahren zur herstellung von 1,4-dihydropyridinen
MXPA01006049A (en) 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee