DE69836779T2 - Mutierte chimäre DNS-Polymerasen - Google Patents
Mutierte chimäre DNS-Polymerasen Download PDFInfo
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- DE69836779T2 DE69836779T2 DE69836779T DE69836779T DE69836779T2 DE 69836779 T2 DE69836779 T2 DE 69836779T2 DE 69836779 T DE69836779 T DE 69836779T DE 69836779 T DE69836779 T DE 69836779T DE 69836779 T2 DE69836779 T2 DE 69836779T2
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- dna polymerase
- dna
- tma
- amino acid
- thermus
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- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5206597P | 1997-07-09 | 1997-07-09 | |
| US52065P | 1997-07-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69836779D1 DE69836779D1 (de) | 2007-02-15 |
| DE69836779T2 true DE69836779T2 (de) | 2007-04-26 |
Family
ID=21975226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69836779T Expired - Lifetime DE69836779T2 (de) | 1997-07-09 | 1998-07-03 | Mutierte chimäre DNS-Polymerasen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6228628B1 (enExample) |
| EP (1) | EP0892058B1 (enExample) |
| JP (1) | JP4350815B2 (enExample) |
| AT (1) | ATE325877T1 (enExample) |
| CA (1) | CA2240570C (enExample) |
| DE (1) | DE69836779T2 (enExample) |
| ES (1) | ES2263188T3 (enExample) |
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| CN111556900A (zh) | 2017-12-22 | 2020-08-18 | 赛默飞世尔科技波罗的海封闭股份公司 | 包括胺的聚合酶链反应组合物 |
| ES2969883T3 (es) | 2018-03-21 | 2024-05-23 | Hoffmann La Roche | ADN polimerasas para la incorporación eficiente y eficaz de dNTP metilados |
| CN112703248B (zh) | 2018-09-13 | 2025-03-25 | 豪夫迈·罗氏有限公司 | 具有改良链置换能力的突变型dna聚合酶 |
| KR20210084349A (ko) | 2018-10-31 | 2021-07-07 | 일루미나, 인코포레이티드 | 중합효소, 조성물, 및 사용 방법 |
| SG11202012559SA (en) | 2018-12-05 | 2021-01-28 | Illumina Inc | Polymerases, compositions, and methods of use |
| JP7209980B2 (ja) * | 2020-12-11 | 2023-01-23 | 東洋紡株式会社 | Dnaポリメラーゼの5’→3’エキソヌクレアーゼ活性ドメインに特異的に結合する抗体 |
| US12077789B2 (en) | 2021-08-14 | 2024-09-03 | Illumina, Inc. | Polymerases, compositions, and methods of use |
| CN115772533B (zh) * | 2022-08-24 | 2025-06-06 | 江南大学 | 一种细菌连续进化系统、正交易错dna聚合酶及连续进化方法 |
| CN118460500B (zh) * | 2024-04-28 | 2025-01-07 | 湖南艾科瑞生物工程有限公司 | 一种融合dna聚合酶及其制备方法与应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5466591A (en) | 1986-08-22 | 1995-11-14 | Hoffmann-La Roche Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5374553A (en) | 1986-08-22 | 1994-12-20 | Hoffmann-La Roche Inc. | DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima |
| DK0550687T3 (da) * | 1990-09-28 | 1999-12-13 | Hoffmann La Roche | 5' til 3'-exonukleasemutationer af termostabile DNA-polymeraser |
| US5474920A (en) | 1993-11-23 | 1995-12-12 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Modified thermo-resistant DNA polymerases |
| US5912155A (en) * | 1994-09-30 | 1999-06-15 | Life Technologies, Inc. | Cloned DNA polymerases from Thermotoga neapolitana |
| EP0655506B1 (en) * | 1994-10-17 | 1996-09-18 | President And Fellows Of Harvard College | DNA polymerases having modified nucleotide binding site for DNA sequencing |
| US5614365A (en) | 1994-10-17 | 1997-03-25 | President & Fellow Of Harvard College | DNA polymerase having modified nucleotide binding site for DNA sequencing |
| US5948614A (en) * | 1995-09-08 | 1999-09-07 | Life Technologies, Inc. | Cloned DNA polymerases from thermotoga maritima and mutants thereof |
-
1998
- 1998-06-26 US US09/105,697 patent/US6228628B1/en not_active Expired - Lifetime
- 1998-07-03 EP EP98112327A patent/EP0892058B1/en not_active Expired - Lifetime
- 1998-07-03 AT AT98112327T patent/ATE325877T1/de not_active IP Right Cessation
- 1998-07-03 ES ES98112327T patent/ES2263188T3/es not_active Expired - Lifetime
- 1998-07-03 DE DE69836779T patent/DE69836779T2/de not_active Expired - Lifetime
- 1998-07-07 CA CA002240570A patent/CA2240570C/en not_active Expired - Fee Related
- 1998-07-09 JP JP20853398A patent/JP4350815B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH1189588A (ja) | 1999-04-06 |
| ES2263188T3 (es) | 2006-12-01 |
| ATE325877T1 (de) | 2006-06-15 |
| EP0892058B1 (en) | 2006-05-10 |
| JP4350815B2 (ja) | 2009-10-21 |
| DE69836779D1 (de) | 2007-02-15 |
| CA2240570A1 (en) | 1999-01-09 |
| EP0892058A2 (en) | 1999-01-20 |
| EP0892058A3 (en) | 2001-09-26 |
| US6228628B1 (en) | 2001-05-08 |
| CA2240570C (en) | 2009-12-15 |
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