DE69830751T2 - Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen - Google Patents

Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen Download PDF

Info

Publication number
DE69830751T2
DE69830751T2 DE69830751T DE69830751T DE69830751T2 DE 69830751 T2 DE69830751 T2 DE 69830751T2 DE 69830751 T DE69830751 T DE 69830751T DE 69830751 T DE69830751 T DE 69830751T DE 69830751 T2 DE69830751 T2 DE 69830751T2
Authority
DE
Germany
Prior art keywords
phenylene
bis
methoxy
compound
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69830751T
Other languages
German (de)
English (en)
Other versions
DE69830751D1 (de
Inventor
Michael R. East Hampton Barbachyn
Fred L. Kalamazoo Homa
Antonio Monge
Esteban Santiago
Juan J. Martinez-Irujo
Maria Font
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE69830751D1 publication Critical patent/DE69830751D1/de
Publication of DE69830751T2 publication Critical patent/DE69830751T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
DE69830751T 1997-04-10 1998-04-01 Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen Expired - Fee Related DE69830751T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4323297P 1997-04-10 1997-04-10
US43232P 1997-04-10

Publications (2)

Publication Number Publication Date
DE69830751D1 DE69830751D1 (de) 2005-08-04
DE69830751T2 true DE69830751T2 (de) 2006-05-18

Family

ID=21926169

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69830751T Expired - Fee Related DE69830751T2 (de) 1997-04-10 1998-04-01 Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen
DE69811062T Expired - Fee Related DE69811062T2 (de) 1997-04-10 1998-04-01 Polyaromatische antivirale zusammensetzungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69811062T Expired - Fee Related DE69811062T2 (de) 1997-04-10 1998-04-01 Polyaromatische antivirale zusammensetzungen

Country Status (9)

Country Link
US (2) US5958983A (https=)
EP (1) EP0973735B1 (https=)
JP (1) JP2001519808A (https=)
AT (2) ATE231839T1 (https=)
AU (1) AU6783698A (https=)
DE (2) DE69830751T2 (https=)
DK (1) DK0973735T3 (https=)
ES (2) ES2191292T3 (https=)
WO (1) WO1998045259A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US6197803B1 (en) 1998-12-09 2001-03-06 American Home Products Corporation Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
US6262090B1 (en) 1998-12-09 2001-07-17 American Home Products Corporation Aminopyridine-containing thiourea inhibitors of herpes viruses
US6335350B1 (en) 1998-12-09 2002-01-01 American Home Products Corporation Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
US6166028A (en) 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6201013B1 (en) 1998-12-09 2001-03-13 American Home Products Corporation Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group
WO2000034269A1 (en) * 1998-12-09 2000-06-15 American Home Products Corporation Thiourea inhibitors of herpes viruses
EP1144399A3 (en) * 1998-12-09 2002-09-11 Wyeth Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group
BR9915993A (pt) * 1998-12-09 2001-09-04 American Home Prod Composto, composição farmacêutica, processo para inibir a replicação de um vìrus herpes, e, processo para tratar um paciente sofrendo de uma infecção de vìrus herpes
CZ20012060A3 (cs) * 1998-12-09 2001-11-14 American Home Products Corporation Thiomočovinové sloučeniny obsahující acetamid a substituovaný acetamid jako inhibitory herpes virů
PL349217A1 (en) * 1998-12-09 2002-07-01 American Home Prod Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ME00275B (me) 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
JP2003508512A (ja) * 1999-09-08 2003-03-04 ギルフォード ファーマシュウティカルズ インコーポレイテッド 非ペプチド性サイクロフィリン結合化合物とその用途
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
ATE529406T1 (de) 2002-02-11 2011-11-15 Bayer Healthcare Llc Aryl-harnstoffe als kinase inhibitoren
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
DE10217518A1 (de) * 2002-04-19 2003-11-06 Bayer Ag Lactone
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
CN1777575B (zh) 2003-04-30 2010-05-12 诺瓦提斯公司 作为1-磷酸-鞘氨醇受体调节剂的氨基-丙醇衍生物
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
EP1651595A2 (en) * 2003-05-30 2006-05-03 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
BRPI0412502A (pt) * 2003-07-10 2006-09-19 Achillion Pharmaceuticals Inc derivados de ariltiouréia substituìda úteis como inibidores de replicação viral
EP1663978B1 (en) 2003-07-23 2007-11-28 Bayer Pharmaceuticals Corporation Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
ATE532509T1 (de) * 2003-09-11 2011-11-15 Tibotec Pharm Ltd Mittel zur hemmung des eintritts des hiv-virus
JP5327744B2 (ja) * 2009-03-13 2013-10-30 国立大学法人 鹿児島大学 ジフェニルメタン誘導体を有効成分とする抗ウイルス剤
US12421626B2 (en) 2018-06-29 2025-09-23 Fred Hutchinson Cancer Center Cell-stored barcoded deep mutational scanning libraries and uses of the same
CA3112326A1 (en) 2018-09-12 2020-03-19 Novartis Ag Antiviral pyridopyrazinedione compounds
KR20250127350A (ko) 2019-09-26 2025-08-26 노파르티스 아게 항바이러스성 피라졸로피리디논 화합물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56108759A (en) * 1980-01-29 1981-08-28 Mitsui Toatsu Chem Inc Novel bisphenol compound and its preparation
NL8120075A (nl) * 1981-03-30 1983-02-01 Ciba Geigy Fenoxyfenylisothiourea, fenoxyfenylthiourea als tussenprodukten, de bereiding en toepassing ervan bij de bestrijding van schadelijke organismen.
DE3626309A1 (de) * 1986-08-02 1988-02-18 Stockhausen Chem Fab Gmbh Antivirusmittel
JPH02237922A (ja) * 1989-01-24 1990-09-20 Green Cross Corp:The 抗ウィルス剤
AU8937491A (en) * 1990-10-22 1992-05-20 Research Corporation Technologies, Inc. Aryl and heteroaryl compounds having anti-retrovirus activity
EP0498095B1 (en) * 1991-02-05 1995-01-04 Merrell Dow Pharmaceuticals Inc. Sulfonic stilbene derivatives in the treatment of viral diseases
US5569643A (en) * 1991-03-07 1996-10-29 Nippon Oil Co., Ltd. Grease composition for constant velocity joint
EP0519702A1 (en) * 1991-06-19 1992-12-23 Schering Corporation Orally active antiviral compounds
EP0571083B1 (en) * 1992-05-18 1997-06-18 Kao Corporation Developer additive, toner and developer composition
JP3603315B2 (ja) * 1993-02-19 2004-12-22 日本製紙株式会社 近赤外線吸収剤およびそれを含有した熱線遮蔽材
JP3509082B2 (ja) * 1994-06-23 2004-03-22 日本製紙株式会社 感熱記録体
EP0725320B1 (en) * 1995-01-31 2001-06-20 Mitsubishi Chemical Corporation Charge controlling agent for electrostatic image development, and toner and charge-imparting material employing it

Also Published As

Publication number Publication date
EP0973735B1 (en) 2003-01-29
US6147116A (en) 2000-11-14
WO1998045259A2 (en) 1998-10-15
JP2001519808A (ja) 2001-10-23
ES2243370T3 (es) 2005-12-01
ES2191292T3 (es) 2003-09-01
ATE298741T1 (de) 2005-07-15
WO1998045259A3 (en) 1999-02-25
DE69811062T2 (de) 2003-07-17
DK0973735T3 (da) 2003-06-23
US5958983A (en) 1999-09-28
DE69811062D1 (de) 2003-03-06
ATE231839T1 (de) 2003-02-15
AU6783698A (en) 1998-10-30
DE69830751D1 (de) 2005-08-04
EP0973735A2 (en) 2000-01-26

Similar Documents

Publication Publication Date Title
DE69830751T2 (de) Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen
EP0815861B1 (de) Sulfonamide und ihre Verwendung
DE3623853C2 (de) Distamycinderivate und Verfahren zu deren Herstellung
DE69108299T2 (de) Antiherpes-Peptidderivate mit einem 1,4-Dioxo-C4-N-Terminus.
AT393507B (de) Neue purinylribofuranuronsaeurederivate, verfahren zu deren herstellung und sie enthaltende therapeutische praeparate
CA1237129A (en) Aminoguanidine derivatives and a process for the preparation thereof
DE69115526T2 (de) 2,4-Pyrimidindionderivate und diese enthaltende Arzneimittel
DE68909062T2 (de) Verfahren und Mittel zur Verhinderung der Färbung der Zähne.
DE68925270T2 (de) Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidinderivate und diese enthaltende Arzneimittel
EP0053767A1 (de) Tricyclische Cytosinderivate zur Verwendung in Arzneimitteln und Verfahren zu ihrer Herstellung
CA1091660A (en) 5-iodo-5'-amino-2', 5'-dideoxycytidine and the pharmaceutically acceptable salts thereof
DE2413966A1 (de) Oxamidsaeure-derivate
DE2205744A1 (de) Neue durch einen guanidinylidenrest substituierte heterocyclen und verfahren zu ihrer herstellung
DE2720545B2 (de) Derivate des 2,4-Diamino-6,7-dimethoxychinazolins, ihre Herstellung und pharmazeutische Mittel
EP0315638A1 (de) Verwendung von Sulfonamidderivaten zur Herstellung eines Antivirusmittels.
DE60025270T2 (de) N-substituierte benzyl oder phenyl arylsulfamide und ihre verwendung
DE69627355T2 (de) Durch strahlung aktivierte cytotoxin therapie
DE3447003A1 (de) 7-acylamino-9a-methoxymitosane, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel
DE3879378T2 (de) Amid-verbindungen.
DE69912315T2 (de) ((aminoiminomethyl)amino) alkanecarboxamide und deren therapeutische verwendungen
EP0847996B1 (de) Sulfonamid-substituierte Verbindungen als K-Kanal-Blocker
DE3017026C2 (de) Isoprenylamine und ihre Säureadditionssalze sowie sie enthaltende Antivirus-Mittel für Wirbeltiere
DE69008019T2 (de) Benzothiazol-Derivate.
DE2700561A1 (de) Hydrazinderivate
EP1148048B1 (en) Polyaromatic compounds for treating herpes viral infections

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee