DK0973735T3 - Polyaromatiske antivirale præparater - Google Patents
Polyaromatiske antivirale præparaterInfo
- Publication number
- DK0973735T3 DK0973735T3 DK98913241T DK98913241T DK0973735T3 DK 0973735 T3 DK0973735 T3 DK 0973735T3 DK 98913241 T DK98913241 T DK 98913241T DK 98913241 T DK98913241 T DK 98913241T DK 0973735 T3 DK0973735 T3 DK 0973735T3
- Authority
- DK
- Denmark
- Prior art keywords
- polyaromatic
- antiviral preparations
- antiviral
- preparations
- herpes
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4323297P | 1997-04-10 | 1997-04-10 | |
| PCT/US1998/006152 WO1998045259A2 (en) | 1997-04-10 | 1998-04-01 | Polyaromatic antiviral compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0973735T3 true DK0973735T3 (da) | 2003-06-23 |
Family
ID=21926169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98913241T DK0973735T3 (da) | 1997-04-10 | 1998-04-01 | Polyaromatiske antivirale præparater |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5958983A (https=) |
| EP (1) | EP0973735B1 (https=) |
| JP (1) | JP2001519808A (https=) |
| AT (2) | ATE231839T1 (https=) |
| AU (1) | AU6783698A (https=) |
| DE (2) | DE69830751T2 (https=) |
| DK (1) | DK0973735T3 (https=) |
| ES (2) | ES2191292T3 (https=) |
| WO (1) | WO1998045259A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US6197803B1 (en) | 1998-12-09 | 2001-03-06 | American Home Products Corporation | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
| US6262090B1 (en) | 1998-12-09 | 2001-07-17 | American Home Products Corporation | Aminopyridine-containing thiourea inhibitors of herpes viruses |
| US6335350B1 (en) | 1998-12-09 | 2002-01-01 | American Home Products Corporation | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
| US6166028A (en) | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| US6201013B1 (en) | 1998-12-09 | 2001-03-13 | American Home Products Corporation | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group |
| WO2000034269A1 (en) * | 1998-12-09 | 2000-06-15 | American Home Products Corporation | Thiourea inhibitors of herpes viruses |
| EP1144399A3 (en) * | 1998-12-09 | 2002-09-11 | Wyeth | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group |
| BR9915993A (pt) * | 1998-12-09 | 2001-09-04 | American Home Prod | Composto, composição farmacêutica, processo para inibir a replicação de um vìrus herpes, e, processo para tratar um paciente sofrendo de uma infecção de vìrus herpes |
| CZ20012060A3 (cs) * | 1998-12-09 | 2001-11-14 | American Home Products Corporation | Thiomočovinové sloučeniny obsahující acetamid a substituovaný acetamid jako inhibitory herpes virů |
| PL349217A1 (en) * | 1998-12-09 | 2002-07-01 | American Home Prod | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1140840B1 (en) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ME00275B (me) | 1999-01-13 | 2011-02-10 | Bayer Corp | ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE |
| EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
| JP2003508512A (ja) * | 1999-09-08 | 2003-03-04 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | 非ペプチド性サイクロフィリン結合化合物とその用途 |
| US7371763B2 (en) | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| ATE529406T1 (de) | 2002-02-11 | 2011-11-15 | Bayer Healthcare Llc | Aryl-harnstoffe als kinase inhibitoren |
| SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| DE10217518A1 (de) * | 2002-04-19 | 2003-11-06 | Bayer Ag | Lactone |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| CN1777575B (zh) | 2003-04-30 | 2010-05-12 | 诺瓦提斯公司 | 作为1-磷酸-鞘氨醇受体调节剂的氨基-丙醇衍生物 |
| EP1636585B2 (en) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl ureas with kinase inhibiting activity |
| EP1651595A2 (en) * | 2003-05-30 | 2006-05-03 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| BRPI0412502A (pt) * | 2003-07-10 | 2006-09-19 | Achillion Pharmaceuticals Inc | derivados de ariltiouréia substituìda úteis como inibidores de replicação viral |
| EP1663978B1 (en) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| ATE532509T1 (de) * | 2003-09-11 | 2011-11-15 | Tibotec Pharm Ltd | Mittel zur hemmung des eintritts des hiv-virus |
| JP5327744B2 (ja) * | 2009-03-13 | 2013-10-30 | 国立大学法人 鹿児島大学 | ジフェニルメタン誘導体を有効成分とする抗ウイルス剤 |
| US12421626B2 (en) | 2018-06-29 | 2025-09-23 | Fred Hutchinson Cancer Center | Cell-stored barcoded deep mutational scanning libraries and uses of the same |
| CA3112326A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| KR20250127350A (ko) | 2019-09-26 | 2025-08-26 | 노파르티스 아게 | 항바이러스성 피라졸로피리디논 화합물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56108759A (en) * | 1980-01-29 | 1981-08-28 | Mitsui Toatsu Chem Inc | Novel bisphenol compound and its preparation |
| NL8120075A (nl) * | 1981-03-30 | 1983-02-01 | Ciba Geigy | Fenoxyfenylisothiourea, fenoxyfenylthiourea als tussenprodukten, de bereiding en toepassing ervan bij de bestrijding van schadelijke organismen. |
| DE3626309A1 (de) * | 1986-08-02 | 1988-02-18 | Stockhausen Chem Fab Gmbh | Antivirusmittel |
| JPH02237922A (ja) * | 1989-01-24 | 1990-09-20 | Green Cross Corp:The | 抗ウィルス剤 |
| AU8937491A (en) * | 1990-10-22 | 1992-05-20 | Research Corporation Technologies, Inc. | Aryl and heteroaryl compounds having anti-retrovirus activity |
| EP0498095B1 (en) * | 1991-02-05 | 1995-01-04 | Merrell Dow Pharmaceuticals Inc. | Sulfonic stilbene derivatives in the treatment of viral diseases |
| US5569643A (en) * | 1991-03-07 | 1996-10-29 | Nippon Oil Co., Ltd. | Grease composition for constant velocity joint |
| EP0519702A1 (en) * | 1991-06-19 | 1992-12-23 | Schering Corporation | Orally active antiviral compounds |
| EP0571083B1 (en) * | 1992-05-18 | 1997-06-18 | Kao Corporation | Developer additive, toner and developer composition |
| JP3603315B2 (ja) * | 1993-02-19 | 2004-12-22 | 日本製紙株式会社 | 近赤外線吸収剤およびそれを含有した熱線遮蔽材 |
| JP3509082B2 (ja) * | 1994-06-23 | 2004-03-22 | 日本製紙株式会社 | 感熱記録体 |
| EP0725320B1 (en) * | 1995-01-31 | 2001-06-20 | Mitsubishi Chemical Corporation | Charge controlling agent for electrostatic image development, and toner and charge-imparting material employing it |
-
1998
- 1998-04-01 JP JP54282798A patent/JP2001519808A/ja not_active Withdrawn
- 1998-04-01 AT AT98913241T patent/ATE231839T1/de not_active IP Right Cessation
- 1998-04-01 AT AT01117751T patent/ATE298741T1/de not_active IP Right Cessation
- 1998-04-01 ES ES98913241T patent/ES2191292T3/es not_active Expired - Lifetime
- 1998-04-01 AU AU67836/98A patent/AU6783698A/en not_active Abandoned
- 1998-04-01 DE DE69830751T patent/DE69830751T2/de not_active Expired - Fee Related
- 1998-04-01 US US09/053,177 patent/US5958983A/en not_active Expired - Fee Related
- 1998-04-01 WO PCT/US1998/006152 patent/WO1998045259A2/en not_active Ceased
- 1998-04-01 DE DE69811062T patent/DE69811062T2/de not_active Expired - Fee Related
- 1998-04-01 DK DK98913241T patent/DK0973735T3/da active
- 1998-04-01 EP EP98913241A patent/EP0973735B1/en not_active Expired - Lifetime
- 1998-04-01 ES ES01117751T patent/ES2243370T3/es not_active Expired - Lifetime
-
1999
- 1999-05-11 US US09/309,645 patent/US6147116A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0973735B1 (en) | 2003-01-29 |
| US6147116A (en) | 2000-11-14 |
| WO1998045259A2 (en) | 1998-10-15 |
| JP2001519808A (ja) | 2001-10-23 |
| DE69830751T2 (de) | 2006-05-18 |
| ES2243370T3 (es) | 2005-12-01 |
| ES2191292T3 (es) | 2003-09-01 |
| ATE298741T1 (de) | 2005-07-15 |
| WO1998045259A3 (en) | 1999-02-25 |
| DE69811062T2 (de) | 2003-07-17 |
| US5958983A (en) | 1999-09-28 |
| DE69811062D1 (de) | 2003-03-06 |
| ATE231839T1 (de) | 2003-02-15 |
| AU6783698A (en) | 1998-10-30 |
| DE69830751D1 (de) | 2005-08-04 |
| EP0973735A2 (en) | 2000-01-26 |
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