DE69830301T2 - Modulatoren von insulinrezeptor-aktivität - Google Patents

Modulatoren von insulinrezeptor-aktivität Download PDF

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Publication number
DE69830301T2
DE69830301T2 DE69830301T DE69830301T DE69830301T2 DE 69830301 T2 DE69830301 T2 DE 69830301T2 DE 69830301 T DE69830301 T DE 69830301T DE 69830301 T DE69830301 T DE 69830301T DE 69830301 T2 DE69830301 T2 DE 69830301T2
Authority
DE
Germany
Prior art keywords
insulin
receptor
independently
compound
insulin receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69830301T
Other languages
German (de)
English (en)
Other versions
DE69830301D1 (de
Inventor
M. Lawrence KAUVAR
Richard Sportsman
O. Hugo VILLAR
R. Wayne SPEVAK
A. Ron KOHANSKI
Apparao Satyam
Ryan Koehler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/784,857 external-priority patent/US5830918A/en
Priority claimed from US08/784,854 external-priority patent/US5851988A/en
Priority claimed from US08/916,088 external-priority patent/US6329431B1/en
Application filed by Telik Inc filed Critical Telik Inc
Publication of DE69830301D1 publication Critical patent/DE69830301D1/de
Application granted granted Critical
Publication of DE69830301T2 publication Critical patent/DE69830301T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69830301T 1997-01-15 1998-01-15 Modulatoren von insulinrezeptor-aktivität Expired - Fee Related DE69830301T2 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US78485597A 1997-01-15 1997-01-15
US08/784,857 US5830918A (en) 1997-01-15 1997-01-15 Nonpeptide insulin receptor agonists
US784857 1997-01-15
US784854 1997-01-15
US08/784,854 US5851988A (en) 1997-01-15 1997-01-15 Nonpeptide insulin receptor agonists
US82526997A 1997-03-27 1997-03-27
US825269 1997-03-27
US08/916,088 US6329431B1 (en) 1997-01-15 1997-08-21 Nonpeptide insulin receptor agonists
US916088 1997-08-21
PCT/US1998/000801 WO1998032017A2 (en) 1997-01-15 1998-01-15 Modulators of insulin receptor activity
US784855 2007-04-10

Publications (2)

Publication Number Publication Date
DE69830301D1 DE69830301D1 (de) 2005-06-30
DE69830301T2 true DE69830301T2 (de) 2006-02-02

Family

ID=27542207

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69830301T Expired - Fee Related DE69830301T2 (de) 1997-01-15 1998-01-15 Modulatoren von insulinrezeptor-aktivität

Country Status (9)

Country Link
EP (1) EP0960335B1 (https=)
JP (1) JP2002512685A (https=)
AT (1) ATE296446T1 (https=)
AU (1) AU6026698A (https=)
CA (1) CA2278023A1 (https=)
DE (1) DE69830301T2 (https=)
DK (1) DK0960335T3 (https=)
ES (1) ES2242995T3 (https=)
WO (1) WO1998032017A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875741B2 (en) * 1998-09-02 2005-04-05 Renuka Pillutla Insulin and IGF-1 receptor agonists and antagonists
CA2343934A1 (en) 1998-09-25 2000-04-06 The Children's Medical Center Corporation Short peptides which selectively modulate the activity of protein kinases
TWI234557B (en) * 1999-05-26 2005-06-21 Telik Inc Novel naphthalene ureas as glucose uptake enhancers
WO2000073793A2 (en) * 1999-05-27 2000-12-07 Cecil Yip Identification of compounds modulating insulin receptor activity
FR2796942B1 (fr) * 1999-07-29 2003-02-07 Telik Inc Acides naphtylsulfoniques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2797767B1 (fr) * 1999-08-27 2002-06-14 Centre Nat Rech Scient Utilisation d'acides amines pour la fabrication de medicaments destines au traitement des insulino-resistances
WO2001072771A2 (en) * 2000-03-29 2001-10-04 Dgi Biotechnologies, L.L.C. Insulin and igf-1 receptor agonists and antagonists
AU2002245258A1 (en) * 2001-01-12 2002-07-24 Exelixis, Inc. Modulating insulin receptor signaling
WO2003103648A1 (ja) * 2002-06-05 2003-12-18 株式会社医薬分子設計研究所 糖尿病治療薬
EP1512396A4 (en) * 2002-06-05 2008-12-31 Inst Med Molecular Design Inc HEMMER AGAINST ACTIVATION OF AP-1 AND NFAT
JP4743382B2 (ja) * 2002-06-06 2011-08-10 株式会社医薬分子設計研究所 Ｏ−置換ヒドロキシアリール誘導体
CA2488367A1 (en) * 2002-06-06 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Antiallergic agents
EP1535609A4 (en) * 2002-06-10 2009-01-07 Inst Med Molecular Design Inc Nf-kb activation inhibitors
EA010835B1 (ru) * 2002-06-10 2008-12-30 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. Лекарственное средство для лечения рака
DE10323081A1 (de) * 2003-05-22 2004-12-16 Aventis Pharma Deutschland Gmbh Verwendung eines Polypeptides
AU2006264567A1 (en) * 2005-05-05 2007-01-11 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023231A1 (en) * 1994-02-28 1995-08-31 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cell lines for the identification of substances affecting insulin receptor mediated signal transduction
CA2216806A1 (en) * 1995-03-31 1996-10-03 Merck & Co., Inc. Insulin mimetic and enhancer assay

Also Published As

Publication number Publication date
DE69830301D1 (de) 2005-06-30
AU6026698A (en) 1998-08-07
ATE296446T1 (de) 2005-06-15
EP0960335B1 (en) 2005-05-25
EP0960335A2 (en) 1999-12-01
ES2242995T3 (es) 2005-11-16
CA2278023A1 (en) 1998-07-23
WO1998032017A2 (en) 1998-07-23
JP2002512685A (ja) 2002-04-23
DK0960335T3 (da) 2005-06-20
WO1998032017A3 (en) 1999-02-25

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee