AU6026698A - Modulators of insulin receptor activity - Google Patents

Modulators of insulin receptor activity

Info

Publication number
AU6026698A
AU6026698A AU60266/98A AU6026698A AU6026698A AU 6026698 A AU6026698 A AU 6026698A AU 60266/98 A AU60266/98 A AU 60266/98A AU 6026698 A AU6026698 A AU 6026698A AU 6026698 A AU6026698 A AU 6026698A
Authority
AU
Australia
Prior art keywords
insulin
insulin receptor
receptor
chain
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU60266/98A
Other languages
English (en)
Inventor
Lawrence M. Kauvar
Ryan Koehler
Ron A. Kohanski
Apparao Satyam
Wayne R. Spevak
Richard Sportsman
Hugo O Villar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/784,857 external-priority patent/US5830918A/en
Priority claimed from US08/784,854 external-priority patent/US5851988A/en
Priority claimed from US08/916,088 external-priority patent/US6329431B1/en
Application filed by Telik Inc filed Critical Telik Inc
Publication of AU6026698A publication Critical patent/AU6026698A/en
Priority to AU34362/02A priority Critical patent/AU780473B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU60266/98A 1997-01-15 1998-01-15 Modulators of insulin receptor activity Abandoned AU6026698A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU34362/02A AU780473B2 (en) 1997-01-15 2002-04-16 Modulators of insulin receptor activity

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US78485597A 1997-01-15 1997-01-15
US08784857 1997-01-15
US08/784,857 US5830918A (en) 1997-01-15 1997-01-15 Nonpeptide insulin receptor agonists
US08784854 1997-01-15
US08/784,854 US5851988A (en) 1997-01-15 1997-01-15 Nonpeptide insulin receptor agonists
US08784855 1997-01-15
US82526997A 1997-03-27 1997-03-27
US08825269 1997-03-27
US08916088 1997-08-21
US08/916,088 US6329431B1 (en) 1997-01-15 1997-08-21 Nonpeptide insulin receptor agonists
PCT/US1998/000801 WO1998032017A2 (en) 1997-01-15 1998-01-15 Modulators of insulin receptor activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU34362/02A Division AU780473B2 (en) 1997-01-15 2002-04-16 Modulators of insulin receptor activity

Publications (1)

Publication Number Publication Date
AU6026698A true AU6026698A (en) 1998-08-07

Family

ID=27542207

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60266/98A Abandoned AU6026698A (en) 1997-01-15 1998-01-15 Modulators of insulin receptor activity

Country Status (9)

Country Link
EP (1) EP0960335B1 (https=)
JP (1) JP2002512685A (https=)
AT (1) ATE296446T1 (https=)
AU (1) AU6026698A (https=)
CA (1) CA2278023A1 (https=)
DE (1) DE69830301T2 (https=)
DK (1) DK0960335T3 (https=)
ES (1) ES2242995T3 (https=)
WO (1) WO1998032017A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875741B2 (en) * 1998-09-02 2005-04-05 Renuka Pillutla Insulin and IGF-1 receptor agonists and antagonists
WO2000018895A1 (en) * 1998-09-25 2000-04-06 The Children's Medical Center Corporation Short peptides which selectively modulate the activity of protein kinases
TWI234557B (en) * 1999-05-26 2005-06-21 Telik Inc Novel naphthalene ureas as glucose uptake enhancers
WO2000073793A2 (en) * 1999-05-27 2000-12-07 Cecil Yip Identification of compounds modulating insulin receptor activity
IL147032A0 (en) 1999-07-29 2002-08-14 Telik Inc Novel naphthylsulfonic acids and related compounds as glucose uptake agonists
FR2797767B1 (fr) 1999-08-27 2002-06-14 Centre Nat Rech Scient Utilisation d'acides amines pour la fabrication de medicaments destines au traitement des insulino-resistances
EP1383793B1 (en) * 2000-03-29 2011-10-19 DGI BioTechnologies, L.L.C. Insulin and igf-1 receptor agonists and antagonists
WO2002055664A2 (en) * 2001-01-12 2002-07-18 Exelixis, Inc. Modulating insulin receptor signaling
CN101103977A (zh) * 2002-06-05 2008-01-16 株式会社医药分子设计研究所 糖尿病治疗药
EP1512396A4 (en) * 2002-06-05 2008-12-31 Inst Med Molecular Design Inc HEMMER AGAINST ACTIVATION OF AP-1 AND NFAT
EA009701B1 (ru) * 2002-06-06 2008-02-28 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. Противоаллергические средства
CA2488363C (en) * 2002-06-06 2011-01-04 Institute Of Medicinal Molecular Design, Inc. O-substituted hydroxyaryl derivatives
EA010470B1 (ru) * 2002-06-10 2008-08-29 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. ИНГИБИТОРЫ АКТИВАЦИИ NF-kB
EP1535610A4 (en) * 2002-06-10 2008-12-31 Inst Med Molecular Design Inc THERAPEUTIC CANCER
DE10323081A1 (de) * 2003-05-22 2004-12-16 Aventis Pharma Deutschland Gmbh Verwendung eines Polypeptides
WO2007004060A2 (en) * 2005-05-05 2007-01-11 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1812595A (en) * 1994-02-28 1995-09-11 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Cell lines for the identification of substances affecting insulin receptor mediated signal transduction
CA2216806A1 (en) * 1995-03-31 1996-10-03 Merck & Co., Inc. Insulin mimetic and enhancer assay

Also Published As

Publication number Publication date
JP2002512685A (ja) 2002-04-23
CA2278023A1 (en) 1998-07-23
EP0960335A2 (en) 1999-12-01
WO1998032017A3 (en) 1999-02-25
WO1998032017A2 (en) 1998-07-23
DK0960335T3 (da) 2005-06-20
EP0960335B1 (en) 2005-05-25
DE69830301T2 (de) 2006-02-02
DE69830301D1 (de) 2005-06-30
ATE296446T1 (de) 2005-06-15
ES2242995T3 (es) 2005-11-16

Similar Documents

Publication Publication Date Title
EP0960335B1 (en) Modulators of insulin receptor activity
US5830918A (en) Nonpeptide insulin receptor agonists
US5763198A (en) Screening assays for compounds
Walsh Calmodulin and the regulation of smooth muscle contraction
Tang et al. Initial externalization followed by internalization of beta-adrenergic receptors in rat heart during sepsis
Margolis et al. Activation of Ras by receptor tyrosine kinases.
AU679253B2 (en) Identification of ligands by selective amplification of cells transfected with receptors
US5610018A (en) Substrate for the epidermal growth factor receptor kinase, antibodies thereto and methods of use thereof
Williams et al. Subtype specificity of α-adrenergic receptors in rat heart
Gruppuso et al. Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats.
US5851988A (en) Nonpeptide insulin receptor agonists
JP2000512737A (ja) 試験管内蛍光偏光検定法
AU758115B2 (en) Enzymatic fluorimetric assay of cAMP and adenylate cyclase
EP0873142A1 (en) Screening assays for compounds
US6329431B1 (en) Nonpeptide insulin receptor agonists
AU780473B2 (en) Modulators of insulin receptor activity
US20030078188A1 (en) Modulators of insulin receptor activity
Van Eldik et al. Calmodulin structure and function
US20110111980A1 (en) Method for profiling drug compounds
US20130130277A1 (en) Remedy for diabetes
Rothenberg et al. The insulin receptor tyrosine kinase
WO1995025166A1 (en) Methods for treatment or diagnosis of diseases or conditions associated with abnormal signal transduction
EP1294929B1 (en) Method to detect modulators of vegf kinase domain
Kan Measurement and expression of drug effects
Formisano et al. Antiphosphotyrosine immunoprecipitation of an insulin-stimulated receptor phosphatase activity from FRTL5 cells

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted