ATE296446T1 - Modulatoren von insulinrezeptor-aktivität - Google Patents
Modulatoren von insulinrezeptor-aktivitätInfo
- Publication number
- ATE296446T1 ATE296446T1 AT98903515T AT98903515T ATE296446T1 AT E296446 T1 ATE296446 T1 AT E296446T1 AT 98903515 T AT98903515 T AT 98903515T AT 98903515 T AT98903515 T AT 98903515T AT E296446 T1 ATE296446 T1 AT E296446T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin receptor
- stimulates
- independently
- insulin
- compounds
- Prior art date
Links
- 102000003746 Insulin Receptor Human genes 0.000 title abstract 6
- 108010001127 Insulin Receptor Proteins 0.000 title abstract 6
- 230000000694 effects Effects 0.000 title abstract 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 102000058061 Glucose Transporter Type 4 Human genes 0.000 abstract 1
- 102100025087 Insulin receptor substrate 1 Human genes 0.000 abstract 1
- 101710201824 Insulin receptor substrate 1 Proteins 0.000 abstract 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 abstract 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 abstract 1
- 108091006300 SLC2A4 Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000008727 cellular glucose uptake Effects 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 230000004190 glucose uptake Effects 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001151 other effect Effects 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000005945 translocation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/62—Insulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78485597A | 1997-01-15 | 1997-01-15 | |
| US08/784,857 US5830918A (en) | 1997-01-15 | 1997-01-15 | Nonpeptide insulin receptor agonists |
| US08/784,854 US5851988A (en) | 1997-01-15 | 1997-01-15 | Nonpeptide insulin receptor agonists |
| US82526997A | 1997-03-27 | 1997-03-27 | |
| US08/916,088 US6329431B1 (en) | 1997-01-15 | 1997-08-21 | Nonpeptide insulin receptor agonists |
| PCT/US1998/000801 WO1998032017A2 (en) | 1997-01-15 | 1998-01-15 | Modulators of insulin receptor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296446T1 true ATE296446T1 (de) | 2005-06-15 |
Family
ID=27542207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98903515T ATE296446T1 (de) | 1997-01-15 | 1998-01-15 | Modulatoren von insulinrezeptor-aktivität |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0960335B1 (https=) |
| JP (1) | JP2002512685A (https=) |
| AT (1) | ATE296446T1 (https=) |
| AU (1) | AU6026698A (https=) |
| CA (1) | CA2278023A1 (https=) |
| DE (1) | DE69830301T2 (https=) |
| DK (1) | DK0960335T3 (https=) |
| ES (1) | ES2242995T3 (https=) |
| WO (1) | WO1998032017A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6875741B2 (en) * | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
| CA2343934A1 (en) | 1998-09-25 | 2000-04-06 | The Children's Medical Center Corporation | Short peptides which selectively modulate the activity of protein kinases |
| TWI234557B (en) * | 1999-05-26 | 2005-06-21 | Telik Inc | Novel naphthalene ureas as glucose uptake enhancers |
| WO2000073793A2 (en) * | 1999-05-27 | 2000-12-07 | Cecil Yip | Identification of compounds modulating insulin receptor activity |
| FR2796942B1 (fr) * | 1999-07-29 | 2003-02-07 | Telik Inc | Acides naphtylsulfoniques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant |
| FR2797767B1 (fr) * | 1999-08-27 | 2002-06-14 | Centre Nat Rech Scient | Utilisation d'acides amines pour la fabrication de medicaments destines au traitement des insulino-resistances |
| WO2001072771A2 (en) * | 2000-03-29 | 2001-10-04 | Dgi Biotechnologies, L.L.C. | Insulin and igf-1 receptor agonists and antagonists |
| AU2002245258A1 (en) * | 2001-01-12 | 2002-07-24 | Exelixis, Inc. | Modulating insulin receptor signaling |
| WO2003103648A1 (ja) * | 2002-06-05 | 2003-12-18 | 株式会社医薬分子設計研究所 | 糖尿病治療薬 |
| EP1512396A4 (en) * | 2002-06-05 | 2008-12-31 | Inst Med Molecular Design Inc | HEMMER AGAINST ACTIVATION OF AP-1 AND NFAT |
| JP4743382B2 (ja) * | 2002-06-06 | 2011-08-10 | 株式会社医薬分子設計研究所 | Ｏ−置換ヒドロキシアリール誘導体 |
| CA2488367A1 (en) * | 2002-06-06 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Antiallergic agents |
| EP1535609A4 (en) * | 2002-06-10 | 2009-01-07 | Inst Med Molecular Design Inc | Nf-kb activation inhibitors |
| EA010835B1 (ru) * | 2002-06-10 | 2008-12-30 | Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. | Лекарственное средство для лечения рака |
| DE10323081A1 (de) * | 2003-05-22 | 2004-12-16 | Aventis Pharma Deutschland Gmbh | Verwendung eines Polypeptides |
| AU2006264567A1 (en) * | 2005-05-05 | 2007-01-11 | Valorisation Hsj, Societe En Commandite | Cytokine receptor modulators and uses thereof |
| US7671058B2 (en) | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995023231A1 (en) * | 1994-02-28 | 1995-08-31 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Cell lines for the identification of substances affecting insulin receptor mediated signal transduction |
| CA2216806A1 (en) * | 1995-03-31 | 1996-10-03 | Merck & Co., Inc. | Insulin mimetic and enhancer assay |
-
1998
- 1998-01-15 EP EP98903515A patent/EP0960335B1/en not_active Expired - Lifetime
- 1998-01-15 AT AT98903515T patent/ATE296446T1/de not_active IP Right Cessation
- 1998-01-15 WO PCT/US1998/000801 patent/WO1998032017A2/en not_active Ceased
- 1998-01-15 DE DE69830301T patent/DE69830301T2/de not_active Expired - Fee Related
- 1998-01-15 ES ES98903515T patent/ES2242995T3/es not_active Expired - Lifetime
- 1998-01-15 AU AU60266/98A patent/AU6026698A/en not_active Abandoned
- 1998-01-15 JP JP53453298A patent/JP2002512685A/ja not_active Ceased
- 1998-01-15 DK DK98903515T patent/DK0960335T3/da active
- 1998-01-15 CA CA002278023A patent/CA2278023A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69830301D1 (de) | 2005-06-30 |
| AU6026698A (en) | 1998-08-07 |
| EP0960335B1 (en) | 2005-05-25 |
| EP0960335A2 (en) | 1999-12-01 |
| ES2242995T3 (es) | 2005-11-16 |
| CA2278023A1 (en) | 1998-07-23 |
| WO1998032017A2 (en) | 1998-07-23 |
| JP2002512685A (ja) | 2002-04-23 |
| DK0960335T3 (da) | 2005-06-20 |
| DE69830301T2 (de) | 2006-02-02 |
| WO1998032017A3 (en) | 1999-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |