DE69218981T2 - Verfahren zum Nachweis freier IGF-I, IGF-II, und GH Spiegel in Körperflüssigkeiten - Google Patents

Verfahren zum Nachweis freier IGF-I, IGF-II, und GH Spiegel in Körperflüssigkeiten

Info

Publication number
DE69218981T2
DE69218981T2 DE69218981T DE69218981T DE69218981T2 DE 69218981 T2 DE69218981 T2 DE 69218981T2 DE 69218981 T DE69218981 T DE 69218981T DE 69218981 T DE69218981 T DE 69218981T DE 69218981 T2 DE69218981 T2 DE 69218981T2
Authority
DE
Germany
Prior art keywords
igf
free
levels
capture reagent
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69218981T
Other languages
English (en)
Other versions
DE69218981D1 (de
Inventor
Venkat R Mukku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE69218981D1 publication Critical patent/DE69218981D1/de
Application granted granted Critical
Publication of DE69218981T2 publication Critical patent/DE69218981T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/61—Growth hormones [GH] (Somatotropin)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
DE69218981T 1991-01-17 1992-01-14 Verfahren zum Nachweis freier IGF-I, IGF-II, und GH Spiegel in Körperflüssigkeiten Expired - Lifetime DE69218981T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/642,509 US5198340A (en) 1991-01-17 1991-01-17 Assay for free igf-i, igf-ii, and gh levels in body fluids

Publications (2)

Publication Number Publication Date
DE69218981D1 DE69218981D1 (de) 1997-05-22
DE69218981T2 true DE69218981T2 (de) 1997-09-25

Family

ID=24576872

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69218981T Expired - Lifetime DE69218981T2 (de) 1991-01-17 1992-01-14 Verfahren zum Nachweis freier IGF-I, IGF-II, und GH Spiegel in Körperflüssigkeiten

Country Status (7)

Country Link
US (1) US5198340A (de)
EP (1) EP0495625B1 (de)
AT (1) ATE151883T1 (de)
DE (1) DE69218981T2 (de)
DK (1) DK0495625T3 (de)
ES (1) ES2101802T3 (de)
GR (1) GR3024052T3 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228839A1 (de) 1992-08-29 1994-03-03 Behringwerke Ag Verfahren zum Nachweis und zur Bestimmung von Mediatoren
EP0733205B1 (de) * 1993-12-20 2001-09-26 Subburaman Mohan Verfahren zur freisetzung bindender proteine von liganden
US6346510B1 (en) * 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US5747273A (en) * 1996-05-07 1998-05-05 Diagnostic Systems Laboratories, Inc. Immunoassay of total insulin-like growth factor binding protein-1
US6066464A (en) * 1996-12-10 2000-05-23 Diagnostic Systems Laboratories, Inc. Immunoassay of IGF family of peptides, their binding proteins and related molecules in dried whole blood filter paper spots
US5824467A (en) * 1997-02-25 1998-10-20 Celtrix Pharmaceuticals Methods for predicting drug response
US6221612B1 (en) 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
US6214563B1 (en) 1997-08-01 2001-04-10 Aurora Biosciences Corporation Photon reducing agents for reducing undesired light emission in assays
US6394952B1 (en) * 1998-02-03 2002-05-28 Adeza Biomedical Corporation Point of care diagnostic systems
PL210412B1 (pl) * 2002-05-24 2012-01-31 Schering Corp Izolowane przeciwciało anty-IGFR lub jego fragment, kompozycja farmaceutyczna, zastosowanie, kwas nukleinowy, zrekombinowany wektor, komórka gospodarza, kompleks, polipeptyd i sposób jego wytwarzania
NZ582769A (en) * 2002-10-09 2011-11-25 Dmi Biosciences Inc Diagnosis and monitoring of inflammation, ischemia and appendicitis
PL2274978T3 (pl) 2003-09-12 2015-11-30 Ipsen Biopharmaceuticals Inc Sposoby leczenia niedoboru insulinopodobnego czynnika wzrostu 1 (IGF-1)
US7169560B2 (en) * 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
CN1938428A (zh) 2003-11-12 2007-03-28 先灵公司 多基因表达的质粒系统
PE20050928A1 (es) * 2003-11-21 2005-11-08 Schering Corp Combinaciones terapeuticas de anticuerpo anti-igfr1
US20060024722A1 (en) * 2004-07-30 2006-02-02 Mark Fischer-Colbrie Samples for detection of oncofetal fibronectin and uses thereof
EP2283831A3 (de) * 2004-12-03 2013-10-23 Merck Sharp & Dohme Corp. Biomarker zur Vorauswahl von Patienten für die Anti-IGF1R-Therapie
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
CA2599731A1 (en) * 2005-03-03 2006-09-08 Dmi Biosciences, Inc. Quantification of proteins
JP4875064B2 (ja) * 2005-04-15 2012-02-15 シェーリング コーポレイション 癌を処置または予防するための方法および組成物
AU2006259536A1 (en) * 2005-06-15 2006-12-28 Schering Corporation Anti-IGF1R antibody formulations
CN114544978A (zh) * 2022-03-04 2022-05-27 美康生物科技股份有限公司 一种igf-1检测试剂盒及其制备方法和检测方法
CN116087386A (zh) * 2023-04-11 2023-05-09 西湖欧米(杭州)生物科技有限公司 一种人胰岛素样生长因子检测方法及试剂盒

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005187A (en) * 1974-06-03 1977-01-25 Data Diagnostic Corporation Diagnostic test method
US4015939A (en) * 1976-05-12 1977-04-05 Bio-Rad Laboratories, Inc. Competitive binding thyroid assay with improved bound-free separation step
AT357272B (de) * 1976-09-18 1980-06-25 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum nachweis und zur bestimmung eines spezifischen bindeproteins oder einer damit bindefaehigen substanz
JPS604423B2 (ja) * 1976-12-15 1985-02-04 持田製薬株式会社 ペプチドホルモンの定量方法
US4219335A (en) * 1978-09-18 1980-08-26 E. I. Du Pont De Nemours And Company Immunochemical testing using tagged reagents
NZ190452A (en) * 1978-05-19 1981-04-24 Becton Dickinson Co Solid phase assay receptor contacted with analyte and then with labeled analyte
US4292296A (en) * 1978-09-12 1981-09-29 Baxter Travenol Laboratories, Inc. Diagnostic method
US4333918A (en) * 1979-03-23 1982-06-08 Technicon Instruments Corporation Radioassay for vitamin B12
US4299916A (en) * 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4786606A (en) * 1981-01-23 1988-11-22 Baxter Travenol Laboratories, Inc. Solid phase system for ligand assay
US4477578A (en) * 1982-03-04 1984-10-16 Medical & Scientific, Inc. Method and apparatus for performing assays
US4504585A (en) * 1982-04-05 1985-03-12 Aalto Scientific, Ltd. Affinity immunoassay system
US4469787A (en) * 1982-05-14 1984-09-04 Mallinckrodt Inc. Immunoassay involving soluble complex of second antibody and labeled binding protein
JPS604423A (ja) * 1983-06-22 1985-01-10 Yamaha Motor Co Ltd 小型４輪車
US4594327A (en) * 1983-11-02 1986-06-10 Syntex (U.S.A.) Inc. Assay method for whole blood samples
GB8404843D0 (en) * 1984-02-24 1984-03-28 Amersham Int Plc Free analyte assay
EP0165669A1 (de) * 1984-05-04 1985-12-27 Corning Glass Works Methode zur Messung freien Ligands
US4791068A (en) * 1984-06-22 1988-12-13 Scripps Clinic And Research Foundation Diagnostic assay for inhibitor of tissue-type and urokinase-type plasminogen activators
FI852545L (fi) * 1984-06-29 1985-12-30 Ortho Diagnostic Systems Inc Sandwichanalys av antikroppslektin.
US4680275A (en) * 1985-02-11 1987-07-14 Becton, Dickinson And Company Homogeneous fluorescence immunoassay using a light absorbing material
US4818687A (en) * 1985-02-28 1989-04-04 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
US4704355A (en) * 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
US4737456A (en) * 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
GB8522388D0 (en) * 1985-09-10 1985-10-16 Lepetit Spa Receptor-antibody sandwich assay
ATE130435T1 (de) * 1985-10-04 1995-12-15 Diagnostic Products Corp Verfahren zum messen von freiliganden in biologischen flüssigkeiten.
JPS6298260A (ja) * 1985-10-25 1987-05-07 Nitto Electric Ind Co Ltd 免疫活性物質測定キツト
GB2203836B (en) * 1987-04-24 1991-01-23 Dr Ch Ng Soo Ling Determination of analyte concentration by re-equilibration
AU1232188A (en) * 1987-05-29 1988-12-01 Mallinckrodt, Inc. Novel pair of monoclonal antibodies to insulin-like growth factor i permits immunometric assay for igf-i
US4943522A (en) * 1987-06-01 1990-07-24 Quidel Lateral flow, non-bibulous membrane assay protocols
US5057417A (en) * 1987-06-12 1991-10-15 Genentech, Inc. Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein
GB2207245A (en) * 1987-07-15 1989-01-25 Unilever Plc Specific binding chemiluminescent assay
CA1305664C (en) * 1987-08-06 1992-07-28 Stephen James Lovell System and process for a visible assay for analyte
US4956302A (en) * 1987-09-11 1990-09-11 Abbott Laboratories Lateral flow chromatographic binding assay device
JPH0198969A (ja) * 1987-10-12 1989-04-17 Meiji Milk Prod Co Ltd レセプターの新規な結合測定方法
DK131988A (da) * 1988-03-11 1989-09-12 Erasmus University Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur
DD276532A1 (de) * 1988-10-25 1990-02-28 Akad Wissenschaften Ddr Verfahren zum nachweis von menschlichem wachstumshormon (hgh)
IL92816A0 (en) * 1988-12-22 1990-09-17 Biogrowth Inc Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides
JPH04503109A (ja) * 1989-01-30 1992-06-04 エピトープ，インコーポレイティド アビジン―ビオチン助力のイムノアッセイ

Also Published As

Publication number Publication date
DE69218981D1 (de) 1997-05-22
ATE151883T1 (de) 1997-05-15
US5198340A (en) 1993-03-30
EP0495625B1 (de) 1997-04-16
EP0495625A3 (en) 1993-04-07
ES2101802T3 (es) 1997-07-16
DK0495625T3 (da) 1997-10-06
GR3024052T3 (en) 1997-10-31
EP0495625A2 (de) 1992-07-22

Similar Documents

Publication Publication Date Title
DE69218981D1 (de) Verfahren zum Nachweis freier IGF-I, IGF-II, und GH Spiegel in Körperflüssigkeiten
ATE297950T1 (de) Testverfahren und reagenzien zur quantifizierung von hbnp
DE3852996T2 (de) Immunoassayverfahren zum Nachweis von Antigenen.
DE19882221T1 (de) Verfahren und Vorrichtung zum automatischen Impfen von Kulturmedien mit bakteriellen Proben aus klinischen Probenbehältern
DE69429192T2 (de) Ein verfahren zur bestimmung von kollagenfragmenten in körperflüssigkeiten, ein testkit und mittel zur durchführung des verfahrens, und seine verwendung zur feststellung von mit dem kollagenmetabolismus assoziierten störungen
DE69328622T2 (de) Reagenzien und verfahren zum nachweis und zur quantifizierung von thyroxin in flüssigen proben
ATE198796T1 (de) Vorrichtung und verfahren zur festphase- präzipitationsbestimmung von hdl-cholesterin
DE60204418D1 (de) "High-Density-Lipoprotein"-Testvorrichtung und Verfahren
EP1780537A4 (de) Proteomanalyseverfahren für phosphoryliertes protein
DK1513878T3 (da) Sammensætninger og fremgangsmåder til analyse af Apo B48 og Apo B100
ATE77149T1 (de) Verfahren und testkit zur bestimmung freier wirkstoffe in biologischen fluessigkeiten.
EP0753743A3 (de) Vitamin-D-Bestimmung
WO2000026668A3 (en) S100 proteins and autoantibodies as serum markers for cancer
ATE342506T1 (de) Verfahren und kit zum nachweis und zur identifizierung von kristallen in biologischen flüssigkeiten
ATE111533T1 (de) Verfahren zur bestimmung von nukleinsäuren.
DE3850249D1 (de) Nachweis von analyt in partikel enthaltenden proben.
ATE206522T1 (de) Massensensitive biosensoren
ATE462975T1 (de) Verfahren zum immunochemischen testen des anti- hm1.24-antikörpers
ATE121197T1 (de) Immunometrisches verfahren zum nachweis von lipoprotein-teilchen, anti-lp(a) monoklonale antikörper und ihre anwendung zur diagnose von atherosklerose.
ES535553A0 (es) Un metodo para detectar un anticuerpo o un antigeno contenido en una muestra de fluido de origen biologico.
FR2805545B1 (fr) Procede electrochimique de detection d'acides nucleiques
ATE323286T1 (de) Verfahren zum bestimmen von autoantikörpern
ATE208040T1 (de) Immunoassay-reagenzien, testsätze und verfahren
ATE286596T1 (de) Chemische modifikation von antikörpern und antigenen
ATE347108T1 (de) Zusammensetzungen und verfahren zum bestimmen von aa4rp

Legal Events

Date Code Title Description
8364 No opposition during term of opposition