DE69829510D1 - Stabile Zubereitung enthaltend Acetylsalicylsäure und Siliconöl zur äusseren Anwendung - Google Patents

Stabile Zubereitung enthaltend Acetylsalicylsäure und Siliconöl zur äusseren Anwendung

Info

Publication number
DE69829510D1
DE69829510D1 DE69829510T DE69829510T DE69829510D1 DE 69829510 D1 DE69829510 D1 DE 69829510D1 DE 69829510 T DE69829510 T DE 69829510T DE 69829510 T DE69829510 T DE 69829510T DE 69829510 D1 DE69829510 D1 DE 69829510D1
Authority
DE
Germany
Prior art keywords
silicone oil
preparation containing
external use
acetylsalicylic acid
stable preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69829510T
Other languages
English (en)
Other versions
DE69829510T2 (de
Inventor
Noriko Mizobuchi
Yuichi Matsuo
Mitsuhiro Kawada
Shin-Ichi Hisaichi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teikoku Seiyaku Co Ltd
Original Assignee
Teikoku Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Seiyaku Co Ltd filed Critical Teikoku Seiyaku Co Ltd
Application granted granted Critical
Publication of DE69829510D1 publication Critical patent/DE69829510D1/de
Publication of DE69829510T2 publication Critical patent/DE69829510T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69829510T 1997-06-25 1998-06-23 Stabile Zubereitung enthaltend Acetylsalicylsäure und Siliconöl zur äusseren Anwendung Expired - Lifetime DE69829510T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9168522A JPH1112177A (ja) 1997-06-25 1997-06-25 安定なアスピリン含有外用製剤
JP16852297 1997-06-25

Publications (2)

Publication Number Publication Date
DE69829510D1 true DE69829510D1 (de) 2005-04-28
DE69829510T2 DE69829510T2 (de) 2005-07-28

Family

ID=15869592

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69815263T Expired - Lifetime DE69815263T2 (de) 1997-06-25 1998-06-23 Stabile zubereitung auf basis von acetylsalicylsäure zur äusseren anwendung
DE69829510T Expired - Lifetime DE69829510T2 (de) 1997-06-25 1998-06-23 Stabile Zubereitung enthaltend Acetylsalicylsäure und Siliconöl zur äusseren Anwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69815263T Expired - Lifetime DE69815263T2 (de) 1997-06-25 1998-06-23 Stabile zubereitung auf basis von acetylsalicylsäure zur äusseren anwendung

Country Status (14)

Country Link
US (1) US6268355B1 (de)
EP (2) EP0920869B1 (de)
JP (1) JPH1112177A (de)
KR (1) KR20000068311A (de)
CN (1) CN1146426C (de)
AU (1) AU723296B2 (de)
CA (1) CA2264022A1 (de)
DE (2) DE69815263T2 (de)
DK (1) DK0920869T3 (de)
ES (2) ES2200352T3 (de)
HK (1) HK1020013A1 (de)
NO (1) NO990877L (de)
PT (2) PT1273300E (de)
WO (1) WO1998058651A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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HU228233B1 (en) * 1999-12-28 2013-02-28 Teikoku Seiyaku Co Antipruritic agents for external use
JP2001187739A (ja) * 1999-12-28 2001-07-10 Teikoku Seiyaku Co Ltd アレルギー性皮膚疾患治療用外用剤
KR20010007717A (ko) * 2000-06-28 2001-02-05 임준기 마취력과 살균력을 가진 연고제 및 거즈
WO2002038139A1 (fr) * 2000-11-07 2002-05-16 Hisamitsu Pharmaceutical Co., Inc. Preparation pharmaceutique du type a absorption percutanee
EP1392272B1 (de) * 2001-05-11 2014-08-06 Merrion Research III Limited Permeationsverbesserer
HU227496B1 (en) * 2001-11-16 2011-07-28 Zoltan Dardai Transdermal pharmaceutical composition containing aspirine for the treatment of sclerosis
KR100978905B1 (ko) * 2002-03-14 2010-08-31 가부시키가이샤 메드렉스 창상용 외용제
JP4868687B2 (ja) * 2002-09-30 2012-02-01 帝國製薬株式会社 ケロイド等の形成抑制外用剤
US7374772B2 (en) * 2002-11-07 2008-05-20 Bommarito Alexander A Topical antifungal treatment
JP4791682B2 (ja) * 2003-02-21 2011-10-12 帝國製薬株式会社 痔疾患用治療剤
JP2004262776A (ja) * 2003-02-21 2004-09-24 Teikoku Seiyaku Co Ltd 血管新生促進剤
US8658625B2 (en) * 2004-02-16 2014-02-25 Teikoku Seiyaku Co., Ltd. External preparation for treating painful skin wound
WO2005084255A2 (en) * 2004-02-27 2005-09-15 Keith Alec D Aspirin transdermal patch
US20060067995A1 (en) * 2004-07-02 2006-03-30 Heng Wan Sia P Topical and/or transdermal bioactive compound delivery system
KR101276754B1 (ko) 2004-07-19 2013-06-19 바이오콘 리미티드 인슐린―올리고머 접합체，제형 및 이들의 용도
EP2203181B1 (de) 2007-10-16 2018-02-14 Biocon Limited Oral zu verabreichende feste pharmazeutische zusammensetzung und verfahren dafür
GB2533669B (en) 2014-12-23 2016-12-14 Innovate Pharmaceuticals Ltd Salicylate compound composition
CN104840475B (zh) * 2015-03-26 2019-08-06 北京农学院 阿司匹林用于制备穴位激活剂的用途
EP3463378A4 (de) 2016-06-03 2020-01-08 Otitopic Inc. Trockenpulverformulierungen zur inhalation
CA3026108A1 (en) 2016-06-10 2017-12-14 Clarity Cosmetics Inc. Non-comedogenic hair and scalp care formulations and method for use

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GB469526A (en) * 1936-10-02 1937-07-27 Earl Barger Putt Acetyl-salicylic acid composition
US4012508A (en) * 1975-02-03 1977-03-15 Burton Verna M Topical composition and method
DE2755224A1 (de) * 1976-12-15 1978-07-13 Procter & Gamble Schmerzen und entzuendungen linderndes mittel zur oertlichen anwendung
US4219548A (en) 1978-09-01 1980-08-26 The Procter & Gamble Company Topical anti-inflammatory composition
US4228162A (en) 1979-07-09 1980-10-14 Research Corporation Dimethyl isosorbide in liquid formulation of aspirin
IL68965A (en) * 1983-06-13 1987-02-27 Rafa Labor Ltd Topical pharmaceutical preparation comprising acetylsalicylic acid for the treatment of dermatological disorders
US4613498A (en) * 1984-10-24 1986-09-23 Frank Crosby Hemorrhoid medication
DK8603837A (de) 1985-08-13 1987-02-14
JPH0751515B2 (ja) * 1986-09-10 1995-06-05 明治製菓株式会社 経皮吸収製剤
JP3040427B2 (ja) 1989-05-18 2000-05-15 帝國製薬株式会社 神経痛治療用アスピリン含有軟膏組成物
US5223267A (en) * 1989-05-30 1993-06-29 Purepac, Inc. Analgesic compositions
JPH03112926A (ja) * 1989-09-26 1991-05-14 Kyowa Hakko Kogyo Co Ltd 経皮吸収製剤
JPH04346930A (ja) 1991-05-25 1992-12-02 Sumitomo Pharmaceut Co Ltd 安定なアスピリン腸溶錠
HRP921157A2 (en) * 1991-12-20 1994-10-31 Lohmann Therapie Syst Lts Transdermal system of applying acetilsalicilyc acid in antithrombosys therapy
JP3571730B2 (ja) * 1992-02-26 2004-09-29 ゼリア新薬工業株式会社 サリチル酸配合製剤
JP3273805B2 (ja) * 1992-03-04 2002-04-15 ポーラ化成工業株式会社 消炎鎮痛外用剤
JP3554573B2 (ja) 1992-06-30 2004-08-18 積水化学工業株式会社 アスピリン含有経皮吸収製剤
JPH06183980A (ja) 1992-12-24 1994-07-05 Sekisui Chem Co Ltd アスピリン含有貼付剤の製造方法
DE4332093C2 (de) 1993-09-22 1995-07-13 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung
JPH0873346A (ja) * 1994-09-07 1996-03-19 Sekisui Chem Co Ltd 外用貼付剤
JP3534843B2 (ja) 1994-10-05 2004-06-07 積水化学工業株式会社 経皮吸収貼付剤
JPH08104625A (ja) 1994-10-06 1996-04-23 Sekisui Chem Co Ltd 貼付剤
JPH08113531A (ja) * 1994-10-14 1996-05-07 Sekisui Chem Co Ltd 医療用貼付剤
JPH08208487A (ja) 1995-02-01 1996-08-13 Sekisui Chem Co Ltd 炎症性皮膚疾患治療用外用剤
JP3911642B2 (ja) 1995-06-06 2007-05-09 株式会社加美乃素本舗 皮膚外用剤
GB2319473A (en) * 1995-07-27 1998-05-27 Cal Int Ltd Transdemal patch containing aspirin
DE69635298T2 (de) * 1995-12-26 2006-07-13 Teikoku Seiyaku K.K. Verwendung von Acetylsalicylsäuren zur Herstellung eines Medikaments für die Behandlung von Hautverletzungen
DE19616539A1 (de) * 1996-04-25 1997-11-06 Luitpold Pharma Gmbh Acetylsalicylsäure enthaltende alkoholische Lösungen zur perkutanen Anwendung, deren Verwendung zur antithrombotischen Therapie sowie Arzneimittel

Also Published As

Publication number Publication date
EP0920869A4 (de) 2000-01-26
EP0920869B1 (de) 2003-06-04
CN1146426C (zh) 2004-04-21
DE69829510T2 (de) 2005-07-28
JPH1112177A (ja) 1999-01-19
DE69815263T2 (de) 2004-05-06
NO990877L (no) 1999-04-26
EP1273300A2 (de) 2003-01-08
NO990877D0 (no) 1999-02-24
PT920869E (pt) 2003-08-29
CA2264022A1 (en) 1998-12-30
HK1020013A1 (en) 2000-03-10
AU723296B2 (en) 2000-08-24
ES2200352T3 (es) 2004-03-01
ES2239191T3 (es) 2005-09-16
DE69815263D1 (de) 2003-07-10
EP1273300A3 (de) 2003-01-29
PT1273300E (pt) 2005-06-30
DK0920869T3 (da) 2003-09-22
CN1236316A (zh) 1999-11-24
WO1998058651A1 (fr) 1998-12-30
KR20000068311A (ko) 2000-11-25
US6268355B1 (en) 2001-07-31
EP0920869A1 (de) 1999-06-09
EP1273300B1 (de) 2005-03-23
AU8038398A (en) 1999-01-04

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