DE69811526D1 - Synthetesemethode für polyphenole - Google Patents

Synthetesemethode für polyphenole

Info

Publication number
DE69811526D1
DE69811526D1 DE69811526T DE69811526T DE69811526D1 DE 69811526 D1 DE69811526 D1 DE 69811526D1 DE 69811526 T DE69811526 T DE 69811526T DE 69811526 T DE69811526 T DE 69811526T DE 69811526 D1 DE69811526 D1 DE 69811526D1
Authority
DE
Germany
Prior art keywords
polyphenol
protected
monomeric units
synthetesemethode
polyphenole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69811526T
Other languages
English (en)
Other versions
DE69811526T2 (de
Inventor
J Romanczyk
P Kozikowski
Werner Tueckmantel
E Lippman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mars Inc
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mars Inc filed Critical Mars Inc
Publication of DE69811526D1 publication Critical patent/DE69811526D1/de
Application granted granted Critical
Publication of DE69811526T2 publication Critical patent/DE69811526T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
DE69811526T 1997-10-09 1998-10-09 Synthetesemethode für polyphenole Expired - Lifetime DE69811526T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/948,226 US6207842B1 (en) 1997-10-09 1997-10-09 Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
PCT/US1998/021392 WO1999019319A1 (en) 1997-10-09 1998-10-09 Synthetic methods for polyphenols

Publications (2)

Publication Number Publication Date
DE69811526D1 true DE69811526D1 (en) 2003-03-27
DE69811526T2 DE69811526T2 (de) 2003-11-06

Family

ID=25487506

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811526T Expired - Lifetime DE69811526T2 (de) 1997-10-09 1998-10-09 Synthetesemethode für polyphenole

Country Status (13)

Country Link
US (6) US6207842B1 (de)
EP (1) EP1027345B1 (de)
JP (1) JP2001519426A (de)
KR (1) KR100560463B1 (de)
CN (2) CN101066962A (de)
AT (1) ATE232857T1 (de)
AU (1) AU760031B2 (de)
CA (1) CA2306851A1 (de)
DE (1) DE69811526T2 (de)
DK (1) DK1027345T3 (de)
ES (1) ES2189260T3 (de)
IL (1) IL135344A (de)
WO (1) WO1999019319A1 (de)

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US20030017998A1 (en) * 1997-05-16 2003-01-23 Snow Alan D. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
US6207842B1 (en) * 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US7015338B1 (en) * 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
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US20070004796A1 (en) * 2005-06-29 2007-01-04 Romanczyk Leo Jr Processes for the preparation of protected-(+)-catechin and (-)-epicatechin monomers, for coupling the protected monomers with an activated, protected epicatechin monomer, and for the preparation of epicatechin-(4B,8)-epicatechin or -catechin dimers and their digallates
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US20070149660A1 (en) 2005-10-27 2007-06-28 Vijayendra Kumar Stabilized polyolefin compositions
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Also Published As

Publication number Publication date
US7268240B2 (en) 2007-09-11
US6207842B1 (en) 2001-03-27
US20040236123A1 (en) 2004-11-25
JP2001519426A (ja) 2001-10-23
ATE232857T1 (de) 2003-03-15
AU760031B2 (en) 2003-05-08
US6528664B2 (en) 2003-03-04
US20020128493A1 (en) 2002-09-12
AU1076699A (en) 1999-05-03
WO1999019319A1 (en) 1999-04-22
CN100341867C (zh) 2007-10-10
CN101066962A (zh) 2007-11-07
KR100560463B1 (ko) 2006-03-13
DK1027345T3 (da) 2003-06-10
EP1027345A1 (de) 2000-08-16
IL135344A (en) 2005-11-20
CN1302295A (zh) 2001-07-04
US6420572B1 (en) 2002-07-16
EP1027345B1 (de) 2003-02-19
US6849746B2 (en) 2005-02-01
KR20010030986A (ko) 2001-04-16
CA2306851A1 (en) 1999-04-22
US20030176620A1 (en) 2003-09-18
US20040235941A1 (en) 2004-11-25
IL135344A0 (en) 2001-05-20
DE69811526T2 (de) 2003-11-06
ES2189260T3 (es) 2003-07-01

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