DE69805844T2 - Ifnnar/ifn komplex - Google Patents
Ifnnar/ifn komplexInfo
- Publication number
- DE69805844T2 DE69805844T2 DE69805844T DE69805844T DE69805844T2 DE 69805844 T2 DE69805844 T2 DE 69805844T2 DE 69805844 T DE69805844 T DE 69805844T DE 69805844 T DE69805844 T DE 69805844T DE 69805844 T2 DE69805844 T2 DE 69805844T2
- Authority
- DE
- Germany
- Prior art keywords
- ifn
- ifnar
- type
- ifnβ
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 150000003668 tyrosines Chemical class 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6829597P | 1997-12-19 | 1997-12-19 | |
| PCT/US1998/026926 WO1999032141A1 (en) | 1997-12-19 | 1998-12-18 | Ifnar2/ifn complex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69805844D1 DE69805844D1 (de) | 2002-07-11 |
| DE69805844T2 true DE69805844T2 (de) | 2002-10-24 |
Family
ID=22081665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69805844T Expired - Lifetime DE69805844T2 (de) | 1997-12-19 | 1998-12-18 | Ifnnar/ifn komplex |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6372207B1 (enExample) |
| EP (1) | EP1037658B1 (enExample) |
| JP (1) | JP4601163B2 (enExample) |
| KR (1) | KR100593981B1 (enExample) |
| CN (1) | CN1241638C (enExample) |
| AR (1) | AR020315A1 (enExample) |
| AT (1) | ATE218362T1 (enExample) |
| AU (1) | AU755078B2 (enExample) |
| BG (1) | BG64920B1 (enExample) |
| BR (1) | BR9813753A (enExample) |
| CA (1) | CA2311648C (enExample) |
| DE (1) | DE69805844T2 (enExample) |
| DK (1) | DK1037658T3 (enExample) |
| EA (1) | EA003635B1 (enExample) |
| EE (1) | EE200000355A (enExample) |
| ES (1) | ES2174530T3 (enExample) |
| HU (1) | HUP0100456A3 (enExample) |
| IL (2) | IL136855A0 (enExample) |
| NO (1) | NO20002691L (enExample) |
| NZ (1) | NZ504771A (enExample) |
| PL (1) | PL197568B1 (enExample) |
| PT (1) | PT1037658E (enExample) |
| SK (1) | SK9222000A3 (enExample) |
| TR (1) | TR200001961T2 (enExample) |
| UA (1) | UA74132C2 (enExample) |
| WO (1) | WO1999032141A1 (enExample) |
| ZA (1) | ZA9811634B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL122818A0 (en) * | 1997-07-10 | 1998-08-16 | Yeda Res & Dev | Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof |
| AUPP670698A0 (en) * | 1998-10-23 | 1998-11-19 | Monash University | A method of regulation |
| US7138379B2 (en) * | 2000-07-26 | 2006-11-21 | Schering Aktiengesellschaft | Use of the interferon receptor 2c polypeptide chain to enhance the anti-growth effects of type I interferons |
| IL147414A0 (en) | 2001-12-31 | 2002-08-14 | Yeda Res & Dev | Ifnar2 mutants, their production and use |
| US20040175359A1 (en) * | 2002-11-12 | 2004-09-09 | Desjarlais John Rudolph | Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity |
| WO2005019260A1 (ja) * | 2003-08-25 | 2005-03-03 | Toray Industries, Inc. | インターフェロンβ複合体 |
| CN100400664C (zh) * | 2005-09-06 | 2008-07-09 | 中国人民解放军第四军医大学 | 肿瘤血管导向肽与人干扰素α-2b的融合蛋白的制备方法 |
| AU2007351813B2 (en) * | 2006-10-31 | 2013-10-10 | East Carolina University | Fusion proteins comprising an anti-inflammatory cytokine and an antigen for treatment of immune disorders |
| GB0715383D0 (en) * | 2007-08-08 | 2007-09-19 | Asterion Ltd | Interferon |
| GB0815216D0 (en) * | 2008-08-21 | 2008-09-24 | Asterion Ltd | Interleukin |
| CA2757287C (en) | 2009-03-31 | 2019-09-10 | East Carolina University | Cytokines and neuroantigens for treatment of immune disorders |
| KR101293363B1 (ko) * | 2011-02-28 | 2013-08-05 | 성균관대학교산학협력단 | 인터페론 수용체 유전자를 포함하는 조류독감 예방용 조성물 |
| US9902770B2 (en) * | 2013-03-15 | 2018-02-27 | Janssen Biotech, Inc. | Interferon alpha and omega antibody antagonists |
| LT6164B (lt) | 2013-10-15 | 2015-06-25 | Uab Biotechnologinės Farmacijos Centras "Biotechpharma" | Sulieti interferono-alfa 5 baltymai su kitu citokinu ir jų gamybos būdas |
| US20190241878A1 (en) | 2016-07-01 | 2019-08-08 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
| CA3067539A1 (en) * | 2017-06-20 | 2018-12-27 | The Board Of Regents Of The University Of Texas System | Interferon prodrug for the treatment of cancer |
| CA3073537A1 (en) | 2017-08-22 | 2019-02-28 | Sanabio, Llc | Soluble interferon receptors and uses thereof |
| CN112646783B (zh) * | 2020-12-30 | 2023-12-01 | 广州医科大学附属市八医院 | 表达基因、经基因修饰的受精卵的构建方法和小鼠模型的构建方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106591A (en) | 1992-09-03 | 2008-03-20 | Yeda Res & Dev | Interferon alpha/beta binding protein, its preparation and pharmaceutical compositions containing it |
| US5821078A (en) * | 1992-09-03 | 1998-10-13 | Yeda Research And Development Co. Ltd. | Nucleic acid encoding interferon-α/β binding protein |
| IL107378A (en) * | 1993-10-24 | 2005-05-17 | Yeda Res & Dev | SOLUBLE INTERFERON alpha-RECEPTOR, ITS PREPARATION AND USE |
-
1998
- 1998-12-18 EE EEP200000355A patent/EE200000355A/xx unknown
- 1998-12-18 NZ NZ504771A patent/NZ504771A/xx unknown
- 1998-12-18 AU AU19269/99A patent/AU755078B2/en not_active Ceased
- 1998-12-18 PT PT98964071T patent/PT1037658E/pt unknown
- 1998-12-18 PL PL341423A patent/PL197568B1/pl not_active IP Right Cessation
- 1998-12-18 ZA ZA9811634A patent/ZA9811634B/xx unknown
- 1998-12-18 EP EP98964071A patent/EP1037658B1/en not_active Expired - Lifetime
- 1998-12-18 AR ARP980106515A patent/AR020315A1/es active IP Right Grant
- 1998-12-18 HU HU0100456A patent/HUP0100456A3/hu unknown
- 1998-12-18 CN CNB988123924A patent/CN1241638C/zh not_active Expired - Fee Related
- 1998-12-18 CA CA2311648A patent/CA2311648C/en not_active Expired - Fee Related
- 1998-12-18 TR TR2000/01961T patent/TR200001961T2/xx unknown
- 1998-12-18 SK SK922-2000A patent/SK9222000A3/sk unknown
- 1998-12-18 DK DK98964071T patent/DK1037658T3/da active
- 1998-12-18 ES ES98964071T patent/ES2174530T3/es not_active Expired - Lifetime
- 1998-12-18 BR BR9813753-0A patent/BR9813753A/pt not_active Application Discontinuation
- 1998-12-18 EA EA200000685A patent/EA003635B1/ru not_active IP Right Cessation
- 1998-12-18 UA UA2000074350A patent/UA74132C2/uk unknown
- 1998-12-18 AT AT98964071T patent/ATE218362T1/de not_active IP Right Cessation
- 1998-12-18 WO PCT/US1998/026926 patent/WO1999032141A1/en not_active Ceased
- 1998-12-18 US US09/215,212 patent/US6372207B1/en not_active Expired - Lifetime
- 1998-12-18 IL IL13685598A patent/IL136855A0/xx active IP Right Grant
- 1998-12-18 DE DE69805844T patent/DE69805844T2/de not_active Expired - Lifetime
- 1998-12-18 JP JP2000525131A patent/JP4601163B2/ja not_active Expired - Fee Related
- 1998-12-18 KR KR1020007006160A patent/KR100593981B1/ko not_active Expired - Fee Related
-
2000
- 2000-05-25 NO NO20002691A patent/NO20002691L/no not_active Application Discontinuation
- 2000-06-15 BG BG104539A patent/BG64920B1/bg unknown
- 2000-06-18 IL IL136855A patent/IL136855A/en not_active IP Right Cessation
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH |