DE69737290T2 - Substrat fangende protein tyrosin phosphatase - Google Patents

Substrat fangende protein tyrosin phosphatase Download PDF

Info

Publication number
DE69737290T2
DE69737290T2 DE69737290T DE69737290T DE69737290T2 DE 69737290 T2 DE69737290 T2 DE 69737290T2 DE 69737290 T DE69737290 T DE 69737290T DE 69737290 T DE69737290 T DE 69737290T DE 69737290 T2 DE69737290 T2 DE 69737290T2
Authority
DE
Germany
Prior art keywords
protein
ptp
tyrosine
tyrosine phosphatase
cas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69737290T
Other languages
German (de)
English (en)
Other versions
DE69737290D1 (en
Inventor
Nicholas Huntington TONKS
J. Andrew Bothell FLINT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cold Spring Harbor Laboratory
Original Assignee
Cold Spring Harbor Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Laboratory filed Critical Cold Spring Harbor Laboratory
Application granted granted Critical
Publication of DE69737290D1 publication Critical patent/DE69737290D1/de
Publication of DE69737290T2 publication Critical patent/DE69737290T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Alcoholic Beverages (AREA)
  • Peptides Or Proteins (AREA)
DE69737290T 1996-07-25 1997-07-24 Substrat fangende protein tyrosin phosphatase Expired - Fee Related DE69737290T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/685,992 US5912138A (en) 1996-07-25 1996-07-25 Substrate trapping protein tyrosine phosphatases
US685992 1996-07-25
PCT/US1997/013016 WO1998004712A2 (en) 1996-07-25 1997-07-24 Substrate trapping protein tyrosine phosphatases

Publications (2)

Publication Number Publication Date
DE69737290D1 DE69737290D1 (en) 2007-03-15
DE69737290T2 true DE69737290T2 (de) 2007-11-08

Family

ID=24754471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737290T Expired - Fee Related DE69737290T2 (de) 1996-07-25 1997-07-24 Substrat fangende protein tyrosin phosphatase

Country Status (9)

Country Link
US (2) US5912138A (enExample)
EP (1) EP0918867B1 (enExample)
JP (1) JP2000515760A (enExample)
AT (1) ATE352625T1 (enExample)
AU (1) AU728405B2 (enExample)
CA (1) CA2262440A1 (enExample)
DE (1) DE69737290T2 (enExample)
ES (1) ES2281915T3 (enExample)
WO (1) WO1998004712A2 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
AU3922999A (en) * 1998-05-21 1999-12-13 Mcgill University Agents interfering with the binding of protein tyrosine phosphatase pest to domains of signalling proteins as inhibitors of cell migration and/or of focal adhesion
US6156551A (en) * 1998-06-05 2000-12-05 Beth Israel Deaconess Medical Center Activated mutants of SH2-domain-containing protein tyrosine phosphatases and methods of use thereof
US6248327B1 (en) 1998-09-11 2001-06-19 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US7176289B1 (en) 1998-09-11 2007-02-13 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US6355786B1 (en) 1998-10-30 2002-03-12 Vanderbilt University Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same
CA2366101A1 (en) * 1999-03-08 2000-09-14 Merck Frosst Canada & Co. Intact cell assay for protein tyrosine phosphatases
US6852520B1 (en) 1999-03-24 2005-02-08 Ceptyr, Inc. DSP-2 dual-specificity phosphatase
US6492157B1 (en) 1999-04-07 2002-12-10 Ceptyr, Inc. DSP-9 dual-specificity phosphatase
US6841369B1 (en) 1999-04-07 2005-01-11 Ceptyr, Inc. DSP-4 dual specificity phosphatase
US6551810B1 (en) 1999-04-23 2003-04-22 Ceptyr, Inc. DSP-10 dual-specificity phosphatase
US6645753B1 (en) 1999-04-27 2003-11-11 Ceptyr, Inc. DSP-5 dual-specificity phosphatase
CA2375145A1 (en) * 1999-06-03 2000-12-14 Cold Spring Harbor Laboratory Substrate trapping protein tyrosine phosphatases
US7078210B2 (en) 1999-07-02 2006-07-18 Ceptyr, Inc. DSP-3 dual-specificity phosphatase
EP1200602A1 (en) 1999-07-20 2002-05-02 Ceptyr, Inc. Dsp-11 dual-specificity map kinase phophatase
WO2001057221A2 (en) 2000-02-02 2001-08-09 Ceptyr, Inc. Dsp-12 and dsp-13 dual-specificity phosphatases
CA2435507A1 (en) * 2000-02-14 2001-08-23 Ceptyr, Inc. Improved assay for protein tyrosine phosphatases
US6825021B2 (en) 2000-09-19 2004-11-30 Ceptyr, Inc. DSP-15 dual-specificity phosphatase
US8071348B2 (en) * 2002-01-14 2011-12-06 Albert Einstein College Of Medicine Of Yeshiva University Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
US20030215899A1 (en) * 2002-02-13 2003-11-20 Ceptyr, Inc. Reversible oxidation of protein tyrosine phosphatases
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
WO2003099227A2 (en) * 2002-05-23 2003-12-04 Ceptyr, Inc. Modulation of ptp1b signal transduction by rna interference
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
EP1576139A4 (en) * 2002-11-26 2007-06-20 Cold Spring Harbor Lab INTERACTIVE PROTEINS AND ASSOCIATED METHODS OF DEP-1 RECEPTOR PROTEIN-TYROSINE PHOSPHATASE
US20070238129A1 (en) * 2006-03-29 2007-10-11 Moyer Susanne C Catalytically inactive enzymes for affinity binding
WO2011060076A1 (en) * 2009-11-10 2011-05-19 Amgen Inc. Anti-c-mpl antibodies
CN113899902B (zh) * 2020-06-22 2024-10-29 上海科技大学 一种酪氨酸磷酸酶底物鉴定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2054602C (en) * 1991-10-31 2003-04-22 Anthony Pawson Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system
US5589375A (en) * 1992-10-06 1996-12-31 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. PTP 1D: a novel protein tyrosine phosphatase
US5585233A (en) * 1993-03-23 1996-12-17 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. PTP-S31: A novel protein tyrosine phosphatase
WO1995006735A2 (en) * 1993-09-01 1995-03-09 The Ludwig Institute For Cancer Research Nucleotide sequences for novel protein tyrosine phosphatases
US5744313A (en) * 1994-12-09 1998-04-28 The Regents Of The University Of California Assay employing novel protein domain which binds tyrosine phosphorylated proteins

Also Published As

Publication number Publication date
US5951979A (en) 1999-09-14
ES2281915T3 (es) 2007-10-01
US5912138A (en) 1999-06-15
WO1998004712A2 (en) 1998-02-05
EP0918867B1 (en) 2007-01-24
EP0918867A2 (en) 1999-06-02
WO1998004712A3 (en) 1998-03-12
JP2000515760A (ja) 2000-11-28
AU728405B2 (en) 2001-01-11
AU5939598A (en) 1999-02-16
ATE352625T1 (de) 2007-02-15
DE69737290D1 (en) 2007-03-15
CA2262440A1 (en) 1998-02-05

Similar Documents

Publication Publication Date Title
DE69737290T2 (de) Substrat fangende protein tyrosin phosphatase
Marfurt et al. Morphology and neurochemistry of canine corneal innervation
Peterson et al. Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia
Golden et al. Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.
DE69636365T2 (de) Peptide und zusammensetzungen, die die apoptose modulieren.
DE69738370T2 (de) Modulatoren des tnf-rezeptor-assoziierten faktors, deren herstellung und verwendungen
JPH09503384A (ja) Jakキナーゼおよびサイトカインシグナルトランスダクションの調節
DE69435020T2 (de) Protein-tyrosin-phosphatase ptp-s31
Carbonell et al. Transient neuronal but persistent astroglial activation of ERK/MAP kinase after focal brain injury in mice
US20020187936A1 (en) Methods of treating liver disease and liver damage with growth hormone and foxM1B
Huang et al. Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function
Bouaita et al. Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy
EP1278537B1 (en) Compositions for stimulating nervous system regeneration and repair by regulating arginase i and polyamine synthesis
DE69305348T2 (de) Proteintyrosinphosphatase alpha - Inhibitoren zur Tumorbehandlung
CN103189503B (zh) 表达人胆碱乙酰转移酶的人神经干细胞及其用途
US20040109844A1 (en) Methods of treating age-related defects and diseases
JP2003501098A (ja) 基質捕捉性プロテインチロシンホスファターゼ
EP1105503B1 (de) ISOLIERTE UND GEREINIGTE HUMANE LÖSLICHE GUANYLYLCYCLASE ALPHA1/BETA1 (hsGC ALPHA1/BETA1)
DE19957689A1 (de) Proteaseresistenter Tumorsuppressor p14(ARF)
EP1541173A1 (en) Method of degrading transcriptional factors of saccharometabolism-associated gene, method of inhibiting the degradation and degradation inhibitor
DE69230943T2 (de) Zellzyklus- Kontrollzusammensetzungen und Methoden diese zu benutzen.
EP1294895A2 (de) Calpain-protease 12
Chen The cAMP pathway is a necessary inductive signal in sympathoadrenal (SA) cell development
AU2002342728A1 (en) Methods for treating liver disease and liver damage with growth hormone and FoxM1B
Plesnila Functional studies of β-arrestins and αB-crystallin as interaction partners of PAR-1 and PAR-2 and their involvement in protective and proliferative signaling pathways in astrocytes

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee