AU728405B2 - Substrate trapping protein tyrosine phosphatases - Google Patents

Substrate trapping protein tyrosine phosphatases Download PDF

Info

Publication number
AU728405B2
AU728405B2 AU59395/98A AU5939598A AU728405B2 AU 728405 B2 AU728405 B2 AU 728405B2 AU 59395/98 A AU59395/98 A AU 59395/98A AU 5939598 A AU5939598 A AU 5939598A AU 728405 B2 AU728405 B2 AU 728405B2
Authority
AU
Australia
Prior art keywords
protein
tyrosine phosphatase
val
leu
protein tyrosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU59395/98A
Other languages
English (en)
Other versions
AU5939598A (en
Inventor
Andrew J. Flint
Nicholas Tonks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cold Spring Harbor Laboratory
Original Assignee
Cold Spring Harbor Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Laboratory filed Critical Cold Spring Harbor Laboratory
Publication of AU5939598A publication Critical patent/AU5939598A/en
Application granted granted Critical
Publication of AU728405B2 publication Critical patent/AU728405B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Alcoholic Beverages (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU59395/98A 1996-07-25 1997-07-24 Substrate trapping protein tyrosine phosphatases Ceased AU728405B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/685,992 US5912138A (en) 1996-07-25 1996-07-25 Substrate trapping protein tyrosine phosphatases
US08/685992 1996-07-25
PCT/US1997/013016 WO1998004712A2 (en) 1996-07-25 1997-07-24 Substrate trapping protein tyrosine phosphatases

Publications (2)

Publication Number Publication Date
AU5939598A AU5939598A (en) 1999-02-16
AU728405B2 true AU728405B2 (en) 2001-01-11

Family

ID=24754471

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59395/98A Ceased AU728405B2 (en) 1996-07-25 1997-07-24 Substrate trapping protein tyrosine phosphatases

Country Status (9)

Country Link
US (2) US5912138A (enExample)
EP (1) EP0918867B1 (enExample)
JP (1) JP2000515760A (enExample)
AT (1) ATE352625T1 (enExample)
AU (1) AU728405B2 (enExample)
CA (1) CA2262440A1 (enExample)
DE (1) DE69737290T2 (enExample)
ES (1) ES2281915T3 (enExample)
WO (1) WO1998004712A2 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
EP1077997A2 (en) * 1998-05-21 2001-02-28 THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING (McGILL UNIVERSITY) Inhibition of the binding of protein tyrosine phosphatase pest to domains of signalling proteins
US6156551A (en) * 1998-06-05 2000-12-05 Beth Israel Deaconess Medical Center Activated mutants of SH2-domain-containing protein tyrosine phosphatases and methods of use thereof
US6248327B1 (en) 1998-09-11 2001-06-19 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US7176289B1 (en) 1998-09-11 2007-02-13 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US6355786B1 (en) 1998-10-30 2002-03-12 Vanderbilt University Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same
JP2002537854A (ja) 1999-03-08 2002-11-12 メルク フロスト カナダ アンド カンパニー タンパク質チロシンホスファターゼの無傷細胞アッセイ
US6852520B1 (en) 1999-03-24 2005-02-08 Ceptyr, Inc. DSP-2 dual-specificity phosphatase
US6841369B1 (en) 1999-04-07 2005-01-11 Ceptyr, Inc. DSP-4 dual specificity phosphatase
US6492157B1 (en) 1999-04-07 2002-12-10 Ceptyr, Inc. DSP-9 dual-specificity phosphatase
EP1173587A1 (en) 1999-04-23 2002-01-23 Ceptyr, Inc. Dsp-10 dual-specificity map kinase phosphatase
US6645753B1 (en) 1999-04-27 2003-11-11 Ceptyr, Inc. DSP-5 dual-specificity phosphatase
AU5284200A (en) * 1999-06-03 2000-12-28 Cold Spring Harbor Laboratory Substrate trapping protein tyrosine phosphatases
US7078210B2 (en) 1999-07-02 2006-07-18 Ceptyr, Inc. DSP-3 dual-specificity phosphatase
WO2001005983A1 (en) 1999-07-20 2001-01-25 Ceptyr, Inc. Dsp-11 dual-specificity map kinase phosphatase
WO2001057221A2 (en) 2000-02-02 2001-08-09 Ceptyr, Inc. Dsp-12 and dsp-13 dual-specificity phosphatases
CA2435507A1 (en) * 2000-02-14 2001-08-23 Ceptyr, Inc. Improved assay for protein tyrosine phosphatases
US6825021B2 (en) 2000-09-19 2004-11-30 Ceptyr, Inc. DSP-15 dual-specificity phosphatase
US8071348B2 (en) * 2002-01-14 2011-12-06 Albert Einstein College Of Medicine Of Yeshiva University Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
US20030215899A1 (en) * 2002-02-13 2003-11-20 Ceptyr, Inc. Reversible oxidation of protein tyrosine phosphatases
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
AU2003283951A1 (en) * 2002-05-23 2004-03-03 Ceptyr, Inc. Modulation of biological signal transduction by rna interference
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
WO2004048549A2 (en) * 2002-11-26 2004-06-10 Cold Spring Harbor Laboratory Dep-1 receptor protein tyrosine phosphatase interacting proteins and related methods
US20070238129A1 (en) * 2006-03-29 2007-10-11 Moyer Susanne C Catalytically inactive enzymes for affinity binding
CA2779683A1 (en) * 2009-11-10 2011-05-19 Amgen Inc. Anti-c-mpl antibodies
CN113899902B (zh) * 2020-06-22 2024-10-29 上海科技大学 一种酪氨酸磷酸酶底物鉴定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352660A (en) * 1991-10-31 1994-10-04 Mount Sinai Hospital Corporation Method for assaying for a substance that affects a SH2-phosphorylated ligand regulatory system
US5589375A (en) * 1992-10-06 1996-12-31 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. PTP 1D: a novel protein tyrosine phosphatase
US5585233A (en) * 1993-03-23 1996-12-17 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. PTP-S31: A novel protein tyrosine phosphatase
JPH09510861A (ja) * 1993-09-01 1997-11-04 ザ・ルドウィッグ・インスティチュート・フォー・キャンサー・リサーチ 新規な蛋白質チロシンホスファターゼに対するヌクレオチド配列の一次構造および機能性発現
US5744313A (en) * 1994-12-09 1998-04-28 The Regents Of The University Of California Assay employing novel protein domain which binds tyrosine phosphorylated proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PROTEIN SCIENCE, 5, 1996, ECKSTEIN ET AL., 5-12 *

Also Published As

Publication number Publication date
ATE352625T1 (de) 2007-02-15
ES2281915T3 (es) 2007-10-01
US5912138A (en) 1999-06-15
EP0918867B1 (en) 2007-01-24
DE69737290T2 (de) 2007-11-08
JP2000515760A (ja) 2000-11-28
AU5939598A (en) 1999-02-16
WO1998004712A3 (en) 1998-03-12
DE69737290D1 (en) 2007-03-15
CA2262440A1 (en) 1998-02-05
EP0918867A2 (en) 1999-06-02
US5951979A (en) 1999-09-14
WO1998004712A2 (en) 1998-02-05

Similar Documents

Publication Publication Date Title
AU728405B2 (en) Substrate trapping protein tyrosine phosphatases
Garton et al. Identification of p130 cas as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST
Garton et al. Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition
US6579972B1 (en) Extracellular signal-regulated kinase, sequences, and methods of production and use
CZ296185B6 (cs) Varianty proteinu p53 a jejich terapeutické pouzití
US6800483B1 (en) Compositions and methods for sensitizing and inhibiting growth of human tumor cells
EP1187924A1 (en) Substrate trapping protein tyrosine phosphatases
US9068174B2 (en) Method for sensitizing tumor cells to chemotherapeutic prodrug CPT-11
US6849438B1 (en) Isolated and purified human soluble guanylyl cyclase α1/β1 (hsgcα1/β1)
Ghosh et al. cDNA encoding a functional feline liver/bone/kidney-type alkaline phosphatase
US9492510B2 (en) Composition and method for inhibiting tumor cell growth
NZ518236A (en) Novel cell cycle checkpoint genes and proteins encoded by human Mus81 gene, holliday junction resolvase
WO1996000586A9 (en) Methods for treating cell proliferative disorders by modulating signal transduction
CA2362936A1 (en) A caspase activated protein kinase

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)