DE69736129T2 - Verfahren und Zusammensetzungen für die Behandlung von neoplastichen Krankheiten - Google Patents
Verfahren und Zusammensetzungen für die Behandlung von neoplastichen Krankheiten Download PDFInfo
- Publication number
- DE69736129T2 DE69736129T2 DE69736129T DE69736129T DE69736129T2 DE 69736129 T2 DE69736129 T2 DE 69736129T2 DE 69736129 T DE69736129 T DE 69736129T DE 69736129 T DE69736129 T DE 69736129T DE 69736129 T2 DE69736129 T2 DE 69736129T2
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- Germany
- Prior art keywords
- plasminogen
- angiostatin
- plasmin
- cells
- plasminogen activator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/49—Urokinase; Tissue plasminogen activator
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/710,305 US5801012A (en) | 1996-09-17 | 1996-09-17 | Methods and compositions for generating angiostatin |
| US710305 | 1996-09-17 | ||
| PCT/US1997/016539 WO1998015574A1 (en) | 1996-09-17 | 1997-09-17 | Methods and compositions for generating angiostatin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69736129D1 DE69736129D1 (de) | 2006-07-27 |
| DE69736129T2 true DE69736129T2 (de) | 2007-01-04 |
Family
ID=24853480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69736129T Expired - Fee Related DE69736129T2 (de) | 1996-09-17 | 1997-09-17 | Verfahren und Zusammensetzungen für die Behandlung von neoplastichen Krankheiten |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5801012A (enExample) |
| EP (2) | EP0964869B1 (enExample) |
| JP (1) | JP4160121B2 (enExample) |
| AT (1) | ATE329926T1 (enExample) |
| AU (1) | AU4422797A (enExample) |
| CA (1) | CA2265550A1 (enExample) |
| DE (1) | DE69736129T2 (enExample) |
| ES (1) | ES2267151T3 (enExample) |
| WO (1) | WO1998015574A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5945403A (en) * | 1997-05-30 | 1999-08-31 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
| US7297331B2 (en) * | 1996-04-03 | 2007-11-20 | The Rogosin Institute | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation |
| EP1001985A1 (en) * | 1997-06-26 | 2000-05-24 | Karolinska Innovations AB | Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo |
| AU1731300A (en) * | 1998-11-25 | 2000-06-13 | Bristol-Myers Squibb Company | Compositions comprising angiostatin and kringle 5 region of plasminogen and methods of use thereof |
| CA2384929C (en) | 1999-09-15 | 2006-12-05 | Mogam Biotechnology Research Institute | A novel angiogenesis inhibitor |
| WO2001058921A2 (en) * | 2000-02-08 | 2001-08-16 | Northwestern University | Methods and compositions for generating angiostatin |
| AU8591901A (en) | 2000-09-05 | 2002-03-22 | Karolinska Innovations Ab | Materials and methods relating to endothelial cell growth inhibitors |
| DE60134885D1 (de) | 2000-11-28 | 2008-08-28 | David M Waisman | Antiangiogene polypeptide |
| ITMI20011995A1 (it) * | 2001-09-26 | 2003-03-26 | Ist Naz Ricerca Sul Cancro | Sostanze ad attivita' antinfiammatoria |
| US7285277B2 (en) * | 2002-03-15 | 2007-10-23 | Mogam Biotechnology Research Institute | Anticancer agent |
| CA2491041A1 (en) * | 2002-07-02 | 2004-01-15 | Novartis Ag | Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap) |
| CA2514873C (en) * | 2002-12-13 | 2012-01-03 | David Waisman | Compositions and methods for inhibiting tumor growth and metastasis |
| US7090654B2 (en) * | 2003-03-28 | 2006-08-15 | Sherwood Services Ag | Catheter with occlusion resistant tip |
| US7141035B2 (en) * | 2003-03-28 | 2006-11-28 | Sherwood Services Ag | Catheter with occlusion resistant tip |
| US7776005B2 (en) * | 2003-03-28 | 2010-08-17 | Covidien Ag | Triple lumen catheter with occlusion resistant tip |
| US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| CN1889929B (zh) * | 2003-11-14 | 2013-04-10 | 阿尔萨公司 | 药物递送媒介物中的赋形剂 |
| KR20070106979A (ko) * | 2004-11-04 | 2007-11-06 | 코비디엔 아게 | 카테터 삽입 장치 |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| WO2009100617A1 (zh) * | 2008-02-04 | 2009-08-20 | Shanghai First People's Hospital | 抑制血管新生的多肽及其应用 |
| US8187231B2 (en) * | 2009-06-26 | 2012-05-29 | Tyco Healthcare Group Lp | Catheterization system |
| CA2715857A1 (en) | 2009-09-30 | 2011-03-30 | Tyco Healthcare Group Lp | Medical catheter having a design providing low recirculation and reversibility |
| US9072867B2 (en) | 2011-09-30 | 2015-07-07 | Covidien Lp | Catheter with external flow channel |
| US8747343B2 (en) | 2011-09-30 | 2014-06-10 | Covidien Lp | Hemodialysis catheter with improved side opening design |
| US9216163B2 (en) | 2013-05-20 | 2015-12-22 | Kyorin Pharmaceutical Co., Ltd. | Method of inhibiting angiogenesis |
| WO2021146215A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2431342C3 (de) * | 1973-07-27 | 1978-10-26 | Behringwerke Ag, 3550 Marburg | Verfahren zur Messung des Plasminogengehaltes durch Bestimmung der Bildung von Fibrin in einer Probe |
| US4968494A (en) * | 1987-03-27 | 1990-11-06 | Merck & Co., Inc. | Methods and compositions for thrombolytic therapy |
| US5135919A (en) | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| US5021404A (en) | 1988-04-20 | 1991-06-04 | The Children's Medical Center Corporation | Angiostatic collagen modulators |
| EP0359036B1 (en) | 1988-09-01 | 1997-03-26 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives |
| PT93847A (pt) | 1989-04-24 | 1990-11-20 | Harvard College | Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem |
| US5290807A (en) | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| US5192744A (en) | 1990-01-12 | 1993-03-09 | Northwestern University | Method of inhibiting angiogenesis of tumors |
| US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| US5639725A (en) * | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
| US5945403A (en) | 1997-05-30 | 1999-08-31 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
| US5837682A (en) | 1996-03-08 | 1998-11-17 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
| CN1636594B (zh) * | 1994-04-26 | 2012-08-29 | 儿童医学中心公司 | 血管生成抑制素和用于抑制血管生成的方法 |
| MX9708217A (es) | 1995-04-26 | 1997-12-31 | Childrens Medical Center | Fragmentos de angiostatina y angiostatina agregada y metodos de uso. |
| US5861372A (en) | 1996-02-22 | 1999-01-19 | The Children's Medical Center Corporation | Aggregate angiostatin and method of use |
| AU6264596A (en) | 1995-06-07 | 1996-12-30 | Children's Medical Center Corporation | Diagnosis, prognosis and monitoring of angiogenesis dependen t diseases |
| DE19529223A1 (de) * | 1995-08-09 | 1997-02-13 | Boehringer Mannheim Gmbh | Verwendung von Plasminogenaktivatoren zum lokalen Knochenaufbau |
| EP0857210B1 (en) | 1995-10-23 | 2003-09-03 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
| US5854221A (en) | 1996-12-12 | 1998-12-29 | The Children's Medical Center Corporation | Endothelial cell proliferation inhibitor and method of use |
| ES2217340T3 (es) | 1995-12-13 | 2004-11-01 | The Children's Medical Center Corporation | Inhibidor de la proliferacion de celulas endoteliales y utilizacion de este. |
| JP4426650B2 (ja) | 1996-05-03 | 2010-03-03 | アボット・ラボラトリーズ | 新規な抗血管形成ペプチド、それをコードするポリヌクレオチド、および血管形成を阻害する方法 |
| EP1001985A1 (en) | 1997-06-26 | 2000-05-24 | Karolinska Innovations AB | Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo |
-
1996
- 1996-09-17 US US08/710,305 patent/US5801012A/en not_active Expired - Fee Related
-
1997
- 1997-09-17 JP JP51753898A patent/JP4160121B2/ja not_active Expired - Fee Related
- 1997-09-17 DE DE69736129T patent/DE69736129T2/de not_active Expired - Fee Related
- 1997-09-17 CA CA002265550A patent/CA2265550A1/en not_active Abandoned
- 1997-09-17 WO PCT/US1997/016539 patent/WO1998015574A1/en not_active Ceased
- 1997-09-17 ES ES97942549T patent/ES2267151T3/es not_active Expired - Lifetime
- 1997-09-17 AT AT97942549T patent/ATE329926T1/de not_active IP Right Cessation
- 1997-09-17 EP EP97942549A patent/EP0964869B1/en not_active Expired - Lifetime
- 1997-09-17 EP EP06112574A patent/EP1705184A1/en not_active Withdrawn
- 1997-09-18 AU AU44227/97A patent/AU4422797A/en not_active Abandoned
- 1997-12-16 US US08/991,761 patent/US6576609B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0964869B1 (en) | 2006-06-14 |
| EP0964869A4 (en) | 2003-06-04 |
| WO1998015574A1 (en) | 1998-04-16 |
| JP2001502534A (ja) | 2001-02-27 |
| CA2265550A1 (en) | 1998-04-16 |
| DE69736129D1 (de) | 2006-07-27 |
| ES2267151T3 (es) | 2007-03-01 |
| JP4160121B2 (ja) | 2008-10-01 |
| EP0964869A1 (en) | 1999-12-22 |
| US6576609B1 (en) | 2003-06-10 |
| EP1705184A1 (en) | 2006-09-27 |
| US5801012A (en) | 1998-09-01 |
| ATE329926T1 (de) | 2006-07-15 |
| AU4422797A (en) | 1998-05-05 |
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