DE69735939T2 - Fhit proteine und nukleinsäuren sowie darauf basierende verfahren - Google Patents
Fhit proteine und nukleinsäuren sowie darauf basierende verfahren Download PDFInfo
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- DE69735939T2 DE69735939T2 DE69735939T DE69735939T DE69735939T2 DE 69735939 T2 DE69735939 T2 DE 69735939T2 DE 69735939 T DE69735939 T DE 69735939T DE 69735939 T DE69735939 T DE 69735939T DE 69735939 T2 DE69735939 T2 DE 69735939T2
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Veterinary Medicine (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
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- Urology & Nephrology (AREA)
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- Reproductive Health (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/598,873 US5928884A (en) | 1996-02-09 | 1996-02-09 | FHIT proteins and nucleic acids and methods based thereon |
| US598873 | 1996-02-09 | ||
| US08/605,430 US6242212B1 (en) | 1996-02-09 | 1996-02-22 | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
| US605430 | 1996-02-22 | ||
| PCT/US1997/001937 WO1997029119A1 (en) | 1996-02-09 | 1997-02-07 | Fhit proteins and nucleic acids and methods based thereon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69735939D1 DE69735939D1 (de) | 2006-06-29 |
| DE69735939T2 true DE69735939T2 (de) | 2007-01-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735939T Expired - Lifetime DE69735939T2 (de) | 1996-02-09 | 1997-02-07 | Fhit proteine und nukleinsäuren sowie darauf basierende verfahren |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US6242212B1 (enExample) |
| EP (2) | EP1795203A3 (enExample) |
| JP (1) | JP2000502570A (enExample) |
| AT (1) | ATE327326T1 (enExample) |
| AU (1) | AU2262197A (enExample) |
| DE (1) | DE69735939T2 (enExample) |
| WO (1) | WO1997029119A1 (enExample) |
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| US6924414B2 (en) * | 2000-04-11 | 2005-08-02 | Thomas Jefferson University | Muir-torre-like syndrome in Fhit deficient mice |
| WO2002064172A2 (en) * | 2001-02-12 | 2002-08-22 | Thomas Jefferson University | Fhit gene therapy prevents tumor development in fhit-deficient mice |
| WO2002064171A1 (en) * | 2001-02-12 | 2002-08-22 | Thomas Jefferson University | Adenoviral transduction of fragile histidine triad (fhit) into cancer cells |
| WO2004082458A2 (en) * | 2003-02-21 | 2004-09-30 | The Johns Hopkins University | Tyrosine kinome |
| EP1644017A2 (en) * | 2003-07-15 | 2006-04-12 | National Research Council Of Canada | Cyclic analogs of human parathyroid hormone for the treatment of conditions characterized by hyperproliferative skin cells |
| US7433520B1 (en) * | 2004-12-01 | 2008-10-07 | Kilimanjaro Partnership | Nosologic system of diagnosis |
| CN101341259B (zh) * | 2005-08-01 | 2011-12-21 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| AU2006291165B2 (en) * | 2005-09-12 | 2013-03-14 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of BCL2-associated cancers |
| AU2006302496A1 (en) * | 2005-10-05 | 2007-04-19 | The Ohio State University Research Foundation | WWOX gene, vectors containing the same, and uses in treatment of cancer |
| EP2591794A1 (en) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors |
| EP2487255A3 (en) | 2006-01-05 | 2012-10-10 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| EP2514433B1 (en) * | 2006-01-05 | 2015-10-21 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer |
| WO2007098954A1 (en) * | 2006-03-03 | 2007-09-07 | Ciemat | A mouse model comprising an engrafted human skin having hypersensitivity to uv-light |
| EP2371971B1 (en) | 2006-03-20 | 2013-11-27 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| WO2008091284A2 (en) * | 2006-07-12 | 2008-07-31 | Vanderbilt University | Vectors for inducing homozygous mutations and methods of using same |
| EP2455493B1 (en) | 2006-07-13 | 2014-01-08 | The Ohio State University Research Foundation | Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases |
| CA2663027A1 (en) * | 2006-09-19 | 2008-08-14 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CN101627134B (zh) * | 2007-01-31 | 2013-11-06 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病（aml）的诊断、预后和治疗的基于微rna的方法和组合物 |
| EP2481806B1 (en) * | 2007-04-30 | 2016-11-09 | The Ohio State University Research Foundation | Methods for pancreatic cancer prognosis |
| EP2559772B1 (en) * | 2007-06-08 | 2015-04-15 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Methods for determining a hepatocellular carcinoma subtype |
| EP2719773A3 (en) | 2007-06-15 | 2014-07-30 | The Ohio State University Research Foundation | miRNA as marker for acute lamphomic leucemia |
| US20090023138A1 (en) * | 2007-07-17 | 2009-01-22 | Zila Biotechnology, Inc. | Oral cancer markers and their detection |
| US8367632B2 (en) * | 2007-07-31 | 2013-02-05 | Ohio State University Research Foundation | Methods for reverting methylation by targeting methyltransferases |
| US8465918B2 (en) | 2007-08-03 | 2013-06-18 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| WO2009026487A1 (en) * | 2007-08-22 | 2009-02-26 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| EP3048177A1 (en) * | 2007-09-06 | 2016-07-27 | The Ohio State University Research Foundation | Microrna signatures in human ovarian cancer |
| AU2008310704B2 (en) * | 2007-10-11 | 2014-03-20 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas |
| CN102137927B (zh) | 2007-10-26 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途 |
| CA2707157A1 (en) * | 2007-11-30 | 2009-06-04 | The Ohio State University Research Foundation | Microrna expression profiling and targeting in peripheral blood in lung cancer |
| CN102015027A (zh) * | 2008-02-28 | 2011-04-13 | 俄亥俄州立大学研究基金会 | 与人慢性淋巴细胞性白血病(ccl)相关的微rna特征和其用途 |
| WO2009108860A2 (en) * | 2008-02-28 | 2009-09-03 | The Ohio University Rasearch Foundation | Microrna-based methods and compositions for the diagnosis, pronosis and treatment of prostate related disorders |
| WO2009152300A1 (en) | 2008-06-11 | 2009-12-17 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| CA2781547A1 (en) | 2009-11-23 | 2011-05-26 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| AU2011326032B2 (en) | 2010-11-12 | 2016-10-06 | The Ohio State University Research Foundation | Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer |
| CN103313706A (zh) | 2010-11-15 | 2013-09-18 | 俄亥俄州立大学研究基金会 | 控制释放粘膜粘合系统 |
| CN103561750A (zh) | 2011-03-07 | 2014-02-05 | 俄亥俄州立大学 | 通过microRNA-155(miR-155)诱导的增变活性使炎症与癌症关联 |
| WO2013056217A1 (en) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
| US9481885B2 (en) | 2011-12-13 | 2016-11-01 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| EP2804960A4 (en) | 2012-01-20 | 2015-08-19 | Univ Ohio State | BREAST CANCER BIOMARK SIGNATURES FOR INVASIVITY AND FORECAST |
| CA2982169A1 (en) | 2015-04-10 | 2016-10-13 | Applied Proteomics, Inc. | Protein biomarker panels for detecting colorectal cancer and advanced adenoma |
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| US4654419A (en) * | 1984-08-08 | 1987-03-31 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen |
| US5362623A (en) * | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| US5352775A (en) * | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| CA2060267A1 (en) * | 1991-02-22 | 1992-08-23 | Joe W. Gray | Chromosome specific staining to detect genetic rearrangements |
| US5330892A (en) * | 1991-03-13 | 1994-07-19 | The Johns Hopkins University | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
| US5952221A (en) * | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
-
1996
- 1996-02-22 US US08/605,430 patent/US6242212B1/en not_active Expired - Lifetime
-
1997
- 1997-02-07 EP EP06010581A patent/EP1795203A3/en not_active Withdrawn
- 1997-02-07 DE DE69735939T patent/DE69735939T2/de not_active Expired - Lifetime
- 1997-02-07 EP EP97905817A patent/EP0892809B1/en not_active Expired - Lifetime
- 1997-02-07 AT AT97905817T patent/ATE327326T1/de not_active IP Right Cessation
- 1997-02-07 AU AU22621/97A patent/AU2262197A/en not_active Abandoned
- 1997-02-07 JP JP9528665A patent/JP2000502570A/ja not_active Ceased
- 1997-02-07 WO PCT/US1997/001937 patent/WO1997029119A1/en not_active Ceased
-
2000
- 2000-11-21 US US09/717,054 patent/US6774217B1/en not_active Expired - Fee Related
-
2004
- 2004-07-13 US US10/889,934 patent/US20040265316A1/en not_active Abandoned
- 2004-08-06 US US10/913,228 patent/US7220834B2/en not_active Expired - Fee Related
-
2006
- 2006-08-30 US US11/513,079 patent/US20070178105A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1795203A2 (en) | 2007-06-13 |
| US20070178105A1 (en) | 2007-08-02 |
| US7220834B2 (en) | 2007-05-22 |
| US20040265316A1 (en) | 2004-12-30 |
| US6242212B1 (en) | 2001-06-05 |
| EP0892809B1 (en) | 2006-05-24 |
| JP2000502570A (ja) | 2000-03-07 |
| AU2262197A (en) | 1997-08-28 |
| EP0892809A1 (en) | 1999-01-27 |
| ATE327326T1 (de) | 2006-06-15 |
| EP0892809A4 (en) | 2002-10-09 |
| DE69735939D1 (de) | 2006-06-29 |
| US20050074797A1 (en) | 2005-04-07 |
| WO1997029119A1 (en) | 1997-08-14 |
| US6774217B1 (en) | 2004-08-10 |
| EP1795203A3 (en) | 2007-07-04 |
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