DE69735939T2 - Fhit proteine und nukleinsäuren sowie darauf basierende verfahren - Google Patents
Fhit proteine und nukleinsäuren sowie darauf basierende verfahren Download PDFInfo
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- DE69735939T2 DE69735939T2 DE69735939T DE69735939T DE69735939T2 DE 69735939 T2 DE69735939 T2 DE 69735939T2 DE 69735939 T DE69735939 T DE 69735939T DE 69735939 T DE69735939 T DE 69735939T DE 69735939 T2 DE69735939 T2 DE 69735939T2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US598873 | 1996-02-09 | ||
| US08/598,873 US5928884A (en) | 1996-02-09 | 1996-02-09 | FHIT proteins and nucleic acids and methods based thereon |
| US08/605,430 US6242212B1 (en) | 1996-02-09 | 1996-02-22 | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
| US605430 | 1996-02-22 | ||
| PCT/US1997/001937 WO1997029119A1 (en) | 1996-02-09 | 1997-02-07 | Fhit proteins and nucleic acids and methods based thereon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69735939D1 DE69735939D1 (de) | 2006-06-29 |
| DE69735939T2 true DE69735939T2 (de) | 2007-01-25 |
Family
ID=27083164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735939T Expired - Lifetime DE69735939T2 (de) | 1996-02-09 | 1997-02-07 | Fhit proteine und nukleinsäuren sowie darauf basierende verfahren |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US6242212B1 (enExample) |
| EP (2) | EP0892809B1 (enExample) |
| JP (1) | JP2000502570A (enExample) |
| AT (1) | ATE327326T1 (enExample) |
| AU (1) | AU2262197A (enExample) |
| DE (1) | DE69735939T2 (enExample) |
| WO (1) | WO1997029119A1 (enExample) |
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| JP2004516002A (ja) * | 2000-04-11 | 2004-06-03 | トーマス・ジェファーソン・ユニバーシティー | Ｆｈｉｔ欠損マウスにおけるミュア−トール様症候群 |
| WO2002064172A2 (en) * | 2001-02-12 | 2002-08-22 | Thomas Jefferson University | Fhit gene therapy prevents tumor development in fhit-deficient mice |
| WO2002064171A1 (en) * | 2001-02-12 | 2002-08-22 | Thomas Jefferson University | Adenoviral transduction of fragile histidine triad (fhit) into cancer cells |
| WO2004082458A2 (en) * | 2003-02-21 | 2004-09-30 | The Johns Hopkins University | Tyrosine kinome |
| CN1822853A (zh) * | 2003-07-15 | 2006-08-23 | 加拿大国家研究委员会 | 用于治疗特征在于过度增殖皮肤细胞的疾病的人类甲状旁腺激素环状类似物 |
| US7433520B1 (en) * | 2004-12-01 | 2008-10-07 | Kilimanjaro Partnership | Nosologic system of diagnosis |
| CN105902559A (zh) * | 2005-08-01 | 2016-08-31 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| WO2007033023A2 (en) * | 2005-09-12 | 2007-03-22 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of bcl2-associated cancers |
| AU2006302496A1 (en) * | 2005-10-05 | 2007-04-19 | The Ohio State University Research Foundation | WWOX gene, vectors containing the same, and uses in treatment of cancer |
| EP2514434B1 (en) | 2006-01-05 | 2015-10-21 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer |
| JP5490413B2 (ja) | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロｒｎａ発現異常 |
| EP2487254B1 (en) | 2006-01-05 | 2015-07-29 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| CA2644525A1 (en) * | 2006-03-03 | 2007-09-07 | Ciemat | A mouse model comprising an engrafted human skin having hypersensitivity to uv-light |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| US20100021895A1 (en) * | 2006-07-12 | 2010-01-28 | Ruley H Earl | Vectors for Inducing Homozygous Mutations and Methods of Using Same |
| EP2436787B1 (en) | 2006-07-13 | 2016-01-20 | The Ohio State University Research Foundation | MIR-21 for diagnosing poor survival prognosis colon adenocarcinoma. |
| JP5426383B2 (ja) * | 2006-09-19 | 2014-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 慢性リンパ球性白血病におけるｍｉＲ−２９およびｍｉＲ−１８１によって制御されるＴＣＬ１発現 |
| CA2667617A1 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CN101627134B (zh) * | 2007-01-31 | 2013-11-06 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病（aml）的诊断、预后和治疗的基于微rna的方法和组合物 |
| US20100144850A1 (en) * | 2007-04-30 | 2010-06-10 | The Ohio State University Research Foundation | Methods for Differentiating Pancreatic Cancer from Normal Pancreatic Function and/or Chronic Pancreatitis |
| JP5690588B2 (ja) * | 2007-06-08 | 2015-03-25 | アメリカ合衆国 | 肝細胞癌のサブタイプを決定し、肝癌幹細胞を検出するための方法 |
| US8053186B2 (en) * | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| US20090023138A1 (en) * | 2007-07-17 | 2009-01-22 | Zila Biotechnology, Inc. | Oral cancer markers and their detection |
| JP2010535782A (ja) * | 2007-07-31 | 2010-11-25 | ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン | Ｄｎｍｔ３ａ及びｄｎｍｔ３ｂを標的にすることによるメチル化を元に戻す方法 |
| ES2570359T3 (es) * | 2007-08-03 | 2016-05-18 | Univ Ohio State Res Found | Regiones ultraconservadas que codifican ARNnc |
| JP5770472B2 (ja) * | 2007-08-22 | 2015-08-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | ヒト急性白血病におけるｅｐｈａ７及びｅｒｋリン酸化の調節解除を誘発するための方法及び組成物 |
| EP2775001B1 (en) * | 2007-09-06 | 2016-03-09 | The Ohio State University Research Foundation | MicroRNA signatures in human ovarian cancer |
| US20100285471A1 (en) * | 2007-10-11 | 2010-11-11 | The Ohio State University Research Foundation | Methods and Compositions for the Diagnosis and Treatment of Esphageal Adenocarcinomas |
| CN102137927B (zh) * | 2007-10-26 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途 |
| JP2011505143A (ja) * | 2007-11-30 | 2011-02-24 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | マイクロｒｎａ発現プロファイリング及び肺癌における末梢血ターゲティング |
| CN102027129B (zh) * | 2008-02-28 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物 |
| US20110052502A1 (en) * | 2008-02-28 | 2011-03-03 | The Ohio State University Research Foundation | MicroRNA Signatures Associated with Human Chronic Lymphocytic Leukemia (CCL) and Uses Thereof |
| AU2009257410B2 (en) | 2008-06-11 | 2014-03-06 | Fudan University | Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| CN102803511A (zh) | 2009-11-23 | 2012-11-28 | 俄亥俄州立大学 | 用于影响肿瘤细胞生长、迁移和侵袭的材料和方法 |
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| AU2011326032B2 (en) | 2010-11-12 | 2016-10-06 | The Ohio State University Research Foundation | Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer |
| WO2012068147A1 (en) | 2010-11-15 | 2012-05-24 | The Ohio State University Research Foundation | Controlled release mucoadhesive systems |
| CA2828772A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | Mutator activity induced by microrna-155 (mir-155) links inflammation and cancer |
| US9249468B2 (en) | 2011-10-14 | 2016-02-02 | The Ohio State University | Methods and materials related to ovarian cancer |
| AU2012352265B2 (en) | 2011-12-13 | 2017-02-16 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| CN105936932A (zh) | 2012-01-20 | 2016-09-14 | 俄亥俄州立大学 | 浸润性和预后的乳腺癌生物标志物标签 |
| JP2018517892A (ja) | 2015-04-10 | 2018-07-05 | アプライド プロテオミクス，インク． | 結腸直腸癌と進行腺腫を検知するためのタンパク質バイオマーカーパネル |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654419A (en) * | 1984-08-08 | 1987-03-31 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen |
| US5362623A (en) * | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| US5352775A (en) * | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| CA2060267A1 (en) * | 1991-02-22 | 1992-08-23 | Joe W. Gray | Chromosome specific staining to detect genetic rearrangements |
| US5330892A (en) * | 1991-03-13 | 1994-07-19 | The Johns Hopkins University | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
| US5952221A (en) * | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
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1996
- 1996-02-22 US US08/605,430 patent/US6242212B1/en not_active Expired - Lifetime
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1997
- 1997-02-07 JP JP9528665A patent/JP2000502570A/ja not_active Ceased
- 1997-02-07 DE DE69735939T patent/DE69735939T2/de not_active Expired - Lifetime
- 1997-02-07 WO PCT/US1997/001937 patent/WO1997029119A1/en not_active Ceased
- 1997-02-07 AU AU22621/97A patent/AU2262197A/en not_active Abandoned
- 1997-02-07 AT AT97905817T patent/ATE327326T1/de not_active IP Right Cessation
- 1997-02-07 EP EP97905817A patent/EP0892809B1/en not_active Expired - Lifetime
- 1997-02-07 EP EP06010581A patent/EP1795203A3/en not_active Withdrawn
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2000
- 2000-11-21 US US09/717,054 patent/US6774217B1/en not_active Expired - Fee Related
-
2004
- 2004-07-13 US US10/889,934 patent/US20040265316A1/en not_active Abandoned
- 2004-08-06 US US10/913,228 patent/US7220834B2/en not_active Expired - Fee Related
-
2006
- 2006-08-30 US US11/513,079 patent/US20070178105A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1795203A3 (en) | 2007-07-04 |
| US20070178105A1 (en) | 2007-08-02 |
| US20040265316A1 (en) | 2004-12-30 |
| US6242212B1 (en) | 2001-06-05 |
| US7220834B2 (en) | 2007-05-22 |
| AU2262197A (en) | 1997-08-28 |
| US20050074797A1 (en) | 2005-04-07 |
| US6774217B1 (en) | 2004-08-10 |
| ATE327326T1 (de) | 2006-06-15 |
| WO1997029119A1 (en) | 1997-08-14 |
| EP0892809B1 (en) | 2006-05-24 |
| JP2000502570A (ja) | 2000-03-07 |
| EP1795203A2 (en) | 2007-06-13 |
| EP0892809A4 (en) | 2002-10-09 |
| DE69735939D1 (de) | 2006-06-29 |
| EP0892809A1 (en) | 1999-01-27 |
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