DE69729128T2 - Taxoid-derivate und verfahren zu ihrer herstellung - Google Patents

Taxoid-derivate und verfahren zu ihrer herstellung Download PDF

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Publication number
DE69729128T2
DE69729128T2 DE69729128T DE69729128T DE69729128T2 DE 69729128 T2 DE69729128 T2 DE 69729128T2 DE 69729128 T DE69729128 T DE 69729128T DE 69729128 T DE69729128 T DE 69729128T DE 69729128 T2 DE69729128 T2 DE 69729128T2
Authority
DE
Germany
Prior art keywords
following formula
docetaxel
compound
paclitaxel
taxoid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69729128T
Other languages
German (de)
English (en)
Other versions
DE69729128D1 (de
Inventor
Tadakatsu Okayama-shi MANDAI
Hiroshi Akaiwa-gun Okumoto
Koji Yokohama-shi Hara
Katsuhiko Yokohama-shi Mikuni
Kozo Yokohama-shi Hara
Yoshinori Tsuchiya
Kosho Yamashina-ku NAKAMURA
Teruhiko Umetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIO RES CORP OF YOKOHAMA YOKOH
BIO RESEARCH Corp OF YOKOHAMA YOKOHAMA
Ensuiko Sugar Refining Co Ltd
Original Assignee
BIO RES CORP OF YOKOHAMA YOKOH
BIO RESEARCH Corp OF YOKOHAMA YOKOHAMA
Ensuiko Sugar Refining Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIO RES CORP OF YOKOHAMA YOKOH, BIO RESEARCH Corp OF YOKOHAMA YOKOHAMA, Ensuiko Sugar Refining Co Ltd filed Critical BIO RES CORP OF YOKOHAMA YOKOH
Publication of DE69729128D1 publication Critical patent/DE69729128D1/de
Application granted granted Critical
Publication of DE69729128T2 publication Critical patent/DE69729128T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
DE69729128T 1997-10-08 1997-10-08 Taxoid-derivate und verfahren zu ihrer herstellung Expired - Lifetime DE69729128T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1997/003615 WO1999018113A1 (fr) 1997-10-08 1997-10-08 Derives taxoides et leur procede de production

Publications (2)

Publication Number Publication Date
DE69729128D1 DE69729128D1 (de) 2004-06-17
DE69729128T2 true DE69729128T2 (de) 2005-04-28

Family

ID=14181286

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69729128T Expired - Lifetime DE69729128T2 (de) 1997-10-08 1997-10-08 Taxoid-derivate und verfahren zu ihrer herstellung

Country Status (7)

Country Link
US (1) US6306893B1 (fr)
EP (1) EP1022284B1 (fr)
JP (1) JP4153660B2 (fr)
AU (1) AU741433B2 (fr)
CA (1) CA2305399A1 (fr)
DE (1) DE69729128T2 (fr)
WO (1) WO1999018113A1 (fr)

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AR030188A1 (es) * 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
WO2004002468A1 (fr) 2002-06-26 2004-01-08 Medigene Oncology Gmbh Procede de production d'une preparation liposomale cationique contenant un compose lipophile
CN100522955C (zh) 2002-08-02 2009-08-05 伊缪诺金公司 含有新型强效紫杉烷的细胞毒性剂及其治疗用途
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
WO2005016241A2 (fr) 2003-05-16 2005-02-24 Intermune, Inc. Ligands des recepteurs des chimiokines synthetiques et leurs methodes d'utilisation
WO2006089209A2 (fr) 2005-02-17 2006-08-24 The Board Of Trustees Of The Leland Stanford Junior University Txr1 et sensibilite au taxane activee basee sur la modulation de la voie mediee par celui-ci
EP1883627B1 (fr) 2005-05-18 2018-04-18 Pharmascience Inc. Composes liants de domaine bir
EP3056196A1 (fr) 2006-03-22 2016-08-17 SynCore Biotechnology CO., LTD Traitement du cancer du sein avec triple récepteur négatif
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
CA2724550C (fr) 2008-05-22 2017-01-03 Kereos, Inc. Combinaison therapeutique anticancereuse
US20110172293A1 (en) 2008-07-08 2011-07-14 Fish Jason E Methods and Compositions for Modulating Angiogenesis
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
CN104203251B (zh) * 2012-03-22 2017-05-31 盐水港精糖株式会社 内包紫杉醇单糖苷和/或紫杉萜单糖苷的脂质体的制造方法
CN104582717B (zh) 2012-07-19 2018-03-13 雷德伍德生物科技股份有限公司 对cd22有特异性的抗体及其使用方法
WO2014074218A1 (fr) 2012-11-12 2014-05-15 Redwood Bioscience, Inc. Composés et procédés pour produire un conjugué
CN105142677B (zh) 2013-02-15 2019-08-30 加利福尼亚大学董事会 嵌合抗原受体及其使用方法
JP6410790B2 (ja) 2013-03-14 2018-10-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ミトコンドリアアルデヒドデヒドロゲナーゼ−２調節因子およびその使用方法
WO2015081282A1 (fr) 2013-11-27 2015-06-04 Redwood Bioscience, Inc. Composés hydrazinyl-pyrrolo et procédés de production d'un conjugué
DK3107899T3 (da) 2014-02-19 2020-11-16 Aviv Therapeutics Inc Mitokondriel aldehyddehydrogenase 2 (aldh2)-bindende polycykliske amider og anvendelse deraf til cancerbehandling
CN110841074B (zh) 2014-03-21 2023-07-18 艾伯维公司 抗-egfr抗体及抗体药物偶联物
US10654875B2 (en) 2015-11-12 2020-05-19 The Board Of Trustees Of The Leland Stanford Junior University Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
EP3231421A1 (fr) 2016-04-11 2017-10-18 Greenaltech, S.L. Utilisations d'un caroténoïde dans le traitement ou la prévention d'états induits par le stress
JP2019515677A (ja) 2016-04-26 2019-06-13 アール．ピー．シェーラー テクノロジーズ エルエルシー 抗体複合体ならびにそれを作製および使用する方法
AU2017299374B2 (en) 2016-06-01 2021-05-27 Servier IP UK Limited Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
JP2019522643A (ja) 2016-06-08 2019-08-15 アッヴィ・インコーポレイテッド 抗ｃｄ９８抗体及び抗体薬物コンジュゲート
CA3027033A1 (fr) 2016-06-08 2017-12-14 Abbvie Inc. Anticorps anti-cd98 et conjugues anticorps-medicament
CA3027103A1 (fr) 2016-06-08 2017-12-14 Abbvie Inc. Anticorps anti-b7-h3 et conjugues anticorps-medicaments
US20200002421A1 (en) 2016-06-08 2020-01-02 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
SG10201914119TA (en) 2016-06-08 2020-02-27 Abbvie Inc Anti-b7-h3 antibodies and antibody drug conjugates
TW201825087A (zh) 2017-01-05 2018-07-16 杏國新藥股份有限公司 胰臟癌治療
US20190367621A1 (en) 2017-01-18 2019-12-05 F1 Oncology, Inc. Chimeric antigen receptors against axl or ror2 and methods of use thereof
EP3388082A1 (fr) 2017-04-13 2018-10-17 Galera Labs, LLC Poly-immunothérapie anticancéreuse avec un complexe de cycle pentaaza macrocyclique
WO2019200181A1 (fr) 2018-04-11 2019-10-17 Ohio State Innovation Foundation Procédés et compositions pour microparticules à libération prolongée pour l'administration de médicament oculaire
EP3823674A4 (fr) 2018-07-18 2022-12-28 Manzanita Pharmaceuticals, Inc. Conjugués pour administrer un agent anticancéreux à des cellules nerveuses, méthodes d'utilisation et leurs procédés de fabrication
CN110003291B (zh) * 2019-01-23 2022-11-29 天津科技大学 一种氟代糖基修饰的紫杉醇类化合物及其合成方法和应用
AU2020253449A1 (en) 2019-04-02 2021-11-18 Kenjockety Biotechnology, Inc. Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
MX2022009355A (es) 2020-01-29 2022-09-02 Kenjockety Biotechnology Inc Anticuerpo anti-mdr1 y uso del mismo.
CN116529267A (zh) 2020-06-04 2023-08-01 肯乔克蒂生物技术股份有限公司 Abcg2外排泵-癌症抗原多特异性抗体及其相关组合物、试剂、试剂盒和方法
CN116323662A (zh) 2020-06-04 2023-06-23 肯乔克蒂生物技术股份有限公司 抗abcg2抗体及其用途
CN116490522A (zh) 2020-09-02 2023-07-25 肯乔克蒂生物技术股份有限公司 抗abcc1抗体及其应用
AU2021380659A1 (en) 2020-11-13 2023-06-01 Kenjockety Biotechnology, Inc. Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
UY39610A (es) 2021-01-20 2022-08-31 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
WO2023114658A1 (fr) 2021-12-13 2023-06-22 Kenjockety Biotechnology, Inc. Anticorps anti-abcb1
WO2023159220A1 (fr) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anticorps anti-cd47

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US5760072A (en) 1995-12-29 1998-06-02 Pharmachemie B.V. Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy
US5767297A (en) * 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
JP3816621B2 (ja) * 1996-02-20 2006-08-30 塩水港精糖株式会社 タキソイド誘導体およびその製造法
JP3786463B2 (ja) * 1996-03-07 2006-06-14 塩水港精糖株式会社 タキソイド誘導体包接物の製造法
JP3786462B2 (ja) * 1996-03-07 2006-06-14 塩水港精糖株式会社 タキソイドの配糖化誘導体およびその製造方法
CA2206739C (fr) * 1997-06-03 2006-10-10 Ensuiko Sugar Refining Co., Ltd. Derive de taxoide et methode de production correspondante

Also Published As

Publication number Publication date
DE69729128D1 (de) 2004-06-17
AU741433B2 (en) 2001-11-29
EP1022284A4 (fr) 2002-01-30
CA2305399A1 (fr) 1999-04-15
JP4153660B2 (ja) 2008-09-24
AU4471697A (en) 1999-04-27
WO1999018113A1 (fr) 1999-04-15
US6306893B1 (en) 2001-10-23
EP1022284B1 (fr) 2004-05-12
EP1022284A1 (fr) 2000-07-26

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