DE69634696T2 - Verfahren und testsystem zur hybridisierungsanalyse unter verwendung von peptidnukleinsäure-sonden - Google Patents
Verfahren und testsystem zur hybridisierungsanalyse unter verwendung von peptidnukleinsäure-sonden Download PDFInfo
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- DE69634696T2 DE69634696T2 DE69634696T DE69634696T DE69634696T2 DE 69634696 T2 DE69634696 T2 DE 69634696T2 DE 69634696 T DE69634696 T DE 69634696T DE 69634696 T DE69634696 T DE 69634696T DE 69634696 T2 DE69634696 T2 DE 69634696T2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
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- Life Sciences & Earth Sciences (AREA)
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- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US495395P | 1995-10-06 | 1995-10-06 | |
| US4953 | 1995-10-06 | ||
| PCT/US1996/015918 WO1997012995A1 (en) | 1995-10-06 | 1996-10-04 | Methods and kit for hybridization analysis using peptide nucleic acid probes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69634696D1 DE69634696D1 (de) | 2005-06-09 |
| DE69634696T2 true DE69634696T2 (de) | 2006-01-19 |
Family
ID=21713369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69634696T Expired - Lifetime DE69634696T2 (de) | 1995-10-06 | 1996-10-04 | Verfahren und testsystem zur hybridisierungsanalyse unter verwendung von peptidnukleinsäure-sonden |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20020012902A1 (https=) |
| EP (1) | EP0854937B9 (https=) |
| JP (1) | JPH11512617A (https=) |
| DE (1) | DE69634696T2 (https=) |
| WO (1) | WO1997012995A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998010097A2 (en) * | 1996-09-03 | 1998-03-12 | Pioneer Hi-Bred International, Inc. | Method and apparatus for single molecule two color fluorescent detection and molecular weight and concentration determination |
| JP4110223B2 (ja) * | 1997-02-27 | 2008-07-02 | インジェネウス・インコーポレーテッド | Ｐｎａプローブを用いる、溶液中でのヌクレオチドアッセイ法 |
| US5846729A (en) * | 1997-02-27 | 1998-12-08 | Lorne Park Research, Inc. | Assaying nucleotides in solution using a fluorescent intensity quenching effect |
| US6046004A (en) * | 1997-02-27 | 2000-04-04 | Lorne Park Research, Inc. | Solution hybridization of nucleic acids with antisense probes having modified backbones |
| US6251591B1 (en) * | 1997-02-27 | 2001-06-26 | Lorne Park Research, Inc. | Quantitative method for detecting nucleotide concentration |
| US6060242A (en) * | 1997-02-27 | 2000-05-09 | Lorne Park Research, Inc. | PNA diagnostic methods |
| DE69834038D1 (de) | 1997-07-01 | 2006-05-18 | Isis Pharmaceutical Inc | Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre |
| US20030165953A1 (en) * | 1997-07-09 | 2003-09-04 | Isao Karube | Method for detecting DNA with probe PNA |
| US6255050B1 (en) | 1998-05-22 | 2001-07-03 | Lorne Park Research, Inc. | Dynamic hybridization system |
| DE69938400T2 (de) * | 1998-12-08 | 2009-04-23 | Boston Probes, Inc., Bedford | Verfahren, Kits und Zusammensetzungen zur Identifizierung von elektrostatisch an Matrizen gebundenen Nukleinsäuren |
| WO2000034521A1 (en) * | 1998-12-08 | 2000-06-15 | Boston Probes, Inc. | Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices |
| US6361671B1 (en) | 1999-01-11 | 2002-03-26 | The Regents Of The University Of California | Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels |
| JP2002540401A (ja) * | 1999-03-19 | 2002-11-26 | ザ ガヴァナーズ オブ ザ ユニヴァーシティー オブ アルバータ | 生物学的及びその他の試料の自動化２次元分析 |
| US6645733B1 (en) | 1999-06-25 | 2003-11-11 | Ingeneus Corporation | Fluorescent intensity method for assaying binding between proteins or peptides |
| US6312956B1 (en) | 1999-10-01 | 2001-11-06 | Vanderbilt University | Nuclear targeted peptide nucleic acid oligomer |
| US7052844B2 (en) * | 1999-12-21 | 2006-05-30 | Ingeneus, Inc. | Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism |
| EP1392853B1 (en) | 2000-08-30 | 2006-04-26 | Avi Biopharma, Inc. | Method for analysis of oligonucleotide analogs |
| EP1320745A4 (en) * | 2000-09-01 | 2008-10-01 | Applera Corp | SYSTEM AND METHOD FOR TEMPERATURE GRADIENT CAPILLARY ELECTROPHORESIS |
| AU2002214569A1 (en) * | 2000-10-11 | 2002-04-22 | Spectrumedix Corporation | System and method for determining the presence of methylated cytosines in polynucleotides |
| EP1432826B1 (en) | 2001-09-24 | 2012-12-12 | Life Technologies Corporation | Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid |
| WO2003033743A1 (en) * | 2001-10-18 | 2003-04-24 | Spectrumedix Corporation | System and method for temperature gradient capillary electrophoresis |
| AU2002348099A1 (en) * | 2001-10-26 | 2003-05-06 | Sequenom Inc. | Resin dispensing device |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| WO2003080857A2 (en) * | 2002-03-21 | 2003-10-02 | Boston Probes,Inc. | Pna oligomers, oligomers sets, methods and kits pertaining to the detection of bacillus anthracis |
| US6872530B2 (en) * | 2002-04-24 | 2005-03-29 | Spectrumedix, Llc | Method for determining the presence of DNA variants using peptide nucleic acid probes |
| WO2003104383A1 (en) * | 2002-06-07 | 2003-12-18 | Millipore Corporation | Kit and process for microbiological for on-site examination of a liquid sample |
| US20040072217A1 (en) * | 2002-06-17 | 2004-04-15 | Affymetrix, Inc. | Methods of analysis of linkage disequilibrium |
| WO2004007690A2 (en) * | 2002-07-16 | 2004-01-22 | Spectrumedix Llc | Method and system for comparative genomics for organisms using temperature gradient electrophoresis |
| US7049073B2 (en) | 2002-10-30 | 2006-05-23 | The University Of Chicago | Double stranded nucleic acid biochips |
| JP4361057B2 (ja) * | 2003-04-30 | 2009-11-11 | モイル，ウィリアム，アール | 生体分子検出および細胞分類用センサ |
| US7303879B2 (en) * | 2003-07-31 | 2007-12-04 | Applera Corporation | Determination of SNP allelic frequencies using temperature gradient electrophoresis |
| US7897747B2 (en) * | 2006-05-25 | 2011-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby |
| EP1995328A1 (en) * | 2007-05-22 | 2008-11-26 | Koninklijke Philips Electronics N.V. | Method of detecting probe-target binding |
| US20090215050A1 (en) * | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
| EP2315015A4 (en) * | 2008-07-22 | 2012-02-08 | Arkray Inc | DEVICE FOR ANALYSIS BY A CAPILLARY ELECTROPHORESIS METHOD |
| JP5395076B2 (ja) * | 2008-07-22 | 2014-01-22 | アークレイ株式会社 | キャピラリー電気泳動法による分析装置および分析方法 |
| WO2010141131A1 (en) | 2009-06-04 | 2010-12-09 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for dna analysis |
| GB2497501A (en) | 2010-10-15 | 2013-06-12 | Lockheed Corp | Micro fluidic optic design |
| US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
| CN109923417B (zh) | 2016-09-08 | 2021-06-08 | 希米斯保健股份有限公司 | 诊断系统和方法 |
| US10349589B2 (en) | 2016-09-08 | 2019-07-16 | Hemex Health, Inc. | Diagnostics systems and methods |
| US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| WO2019060633A2 (en) * | 2017-09-22 | 2019-03-28 | Prozyme, Inc. | USE OF POLYAMINES AS RESOLUTION AGENTS FOR CAPILLARY ELECTROPHORESIS OF GLYCANES MARKETED USING GELS |
| EP3790985B1 (en) | 2018-05-09 | 2026-04-15 | Vibrant Holdings, LLC | Methods of synthesizing a polynucleotide array using photactivated agents |
| WO2020264182A1 (en) | 2019-06-25 | 2020-12-30 | Hemex Health, Inc. | Diagnostics systems and methods |
| CN112326762B (zh) * | 2020-10-29 | 2023-03-21 | 常州大学 | 一种毛细管电泳检测dna四面体的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US6045995A (en) * | 1994-08-24 | 2000-04-04 | Isis Pharmaceuticals, Inc. | Capillary electrophoretic detection of nucleic acids |
| US5582705A (en) * | 1995-05-19 | 1996-12-10 | Iowa State University Research Foundation, Inc. | Multiplexed capillary electrophoresis system |
-
1996
- 1996-10-04 JP JP9514448A patent/JPH11512617A/ja not_active Ceased
- 1996-10-04 US US08/726,093 patent/US20020012902A1/en not_active Abandoned
- 1996-10-04 EP EP96934037A patent/EP0854937B9/en not_active Expired - Lifetime
- 1996-10-04 WO PCT/US1996/015918 patent/WO1997012995A1/en not_active Ceased
- 1996-10-04 DE DE69634696T patent/DE69634696T2/de not_active Expired - Lifetime
-
2003
- 2003-08-07 US US10/636,343 patent/US20050053944A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997012995A1 (en) | 1997-04-10 |
| DE69634696D1 (de) | 2005-06-09 |
| US20050053944A1 (en) | 2005-03-10 |
| EP0854937B9 (en) | 2006-06-28 |
| JPH11512617A (ja) | 1999-11-02 |
| EP0854937A1 (en) | 1998-07-29 |
| EP0854937B1 (en) | 2005-05-04 |
| US20020012902A1 (en) | 2002-01-31 |
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Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US |