DE69634122D1 - Heterocyclische amidverbindungen und deren medizinische verwendung - Google Patents
Heterocyclische amidverbindungen und deren medizinische verwendungInfo
- Publication number
- DE69634122D1 DE69634122D1 DE69634122T DE69634122T DE69634122D1 DE 69634122 D1 DE69634122 D1 DE 69634122D1 DE 69634122 T DE69634122 T DE 69634122T DE 69634122 T DE69634122 T DE 69634122T DE 69634122 D1 DE69634122 D1 DE 69634122D1
- Authority
- DE
- Germany
- Prior art keywords
- medicine
- amide compounds
- heterocyclic amide
- heterocyclic
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10431495 | 1995-04-27 | ||
PCT/JP1996/001171 WO1996033974A1 (fr) | 1995-04-27 | 1996-04-26 | Composes heterocycliques amides et leur utilisation medicinale |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69634122D1 true DE69634122D1 (de) | 2005-02-03 |
Family
ID=14377479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69634122T Expired - Lifetime DE69634122D1 (de) | 1995-04-27 | 1996-04-26 | Heterocyclische amidverbindungen und deren medizinische verwendung |
Country Status (7)
Country | Link |
---|---|
US (1) | US5948785A (de) |
EP (1) | EP0826671B1 (de) |
KR (1) | KR100400639B1 (de) |
CN (2) | CN1188401C (de) |
CA (1) | CA2219364A1 (de) |
DE (1) | DE69634122D1 (de) |
WO (1) | WO1996033974A1 (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4199309B2 (ja) * | 1996-09-06 | 2008-12-17 | 日本化薬株式会社 | 新規アセトアミド誘導体およびプロテアーゼ阻害 |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
US6369080B2 (en) * | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
EP0940400A4 (de) * | 1996-10-25 | 2002-10-02 | Mitsubishi Pharma Corp | Heterocyklische amidverbindungen und ihre medizinische anwendung |
JP2001508796A (ja) * | 1997-01-22 | 2001-07-03 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害薬 |
JP2002513412A (ja) | 1997-04-14 | 2002-05-08 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
EP0977772A1 (de) | 1997-04-14 | 2000-02-09 | Cor Therapeutics, Inc. | Selektive faktor xa-inhibitoren |
AU6896398A (en) | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
AU1684999A (en) * | 1997-12-22 | 1999-07-12 | Yoshitomi Pharmaceutical Industries, Ltd. | Chymase inhibitors |
AU744739B2 (en) * | 1998-02-17 | 2002-02-28 | Nippon Kayaku Kabushiki Kaisha | Novel acetamide derivative and use thereof |
CN1550232A (zh) * | 1998-03-11 | 2004-12-01 | 杂环酰胺化合物在制备自身免疫性疾病抑制剂中的用途 | |
JP3923255B2 (ja) * | 1998-07-15 | 2007-05-30 | 帝人株式会社 | チオベンズイミダゾール誘導体 |
US20050267148A1 (en) * | 1998-07-15 | 2005-12-01 | Teijin Limited | Benzimidazole derivative |
CA2341195A1 (en) * | 1998-08-20 | 2000-03-02 | Mitsunori Waki | Prophylactic or therapeutic composition for ocular circulation disorders |
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
MXPA01011804A (es) * | 1999-05-19 | 2003-09-04 | Pharmacia Corp | Aril y heteroaril pirimidinonas policiclicas sustituidas utiles como anticoagulantes. |
US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
WO2001023349A1 (fr) * | 1999-09-30 | 2001-04-05 | Mitsubishi Chemical Corporation | Derives d'acylsulfonamide |
EP1224945A4 (de) * | 1999-10-25 | 2004-08-18 | Senju Pharma Co | Mittel zur linderung der ziliarmuskelspannung |
EP1142586B1 (de) | 1999-11-01 | 2007-04-25 | Daiichi Asubio Pharma Co., Ltd. | Verwendung von chymase hemmern gegen vaskuläre lipidablagerung |
EP1174151B1 (de) | 2000-02-22 | 2007-01-24 | Daiichi Asubio Pharma Co., Ltd. | Therapeutische behandlung von eosinophilie durch verwendung von chymase-inhibitoren als aktiven bestandteilen |
DE60121695T2 (de) | 2000-02-22 | 2007-08-30 | Daiichi Asubio Pharma Co., Ltd. | Arzneimittel mit chymaseinhibitoren als wirksames mittel zur behandlung von dermatitis mit zweiphasigen hautreaktionen |
CA2368366A1 (en) | 2000-02-22 | 2001-08-30 | Suntory Limited | Medicament for prevention or treatment of fibrosis having chymase inhibitor as effective ingredient |
US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
DE60108948T2 (de) | 2000-04-05 | 2005-11-03 | Pharmacia Corp. | Polyzyclisch aryl und heteroaryl substituierte 4-pyronen verwendbar als selektive hemmung von dem koagulationsprozess |
EP1268428A2 (de) | 2000-04-05 | 2003-01-02 | Pharmacia Corporation | Polyzyklische aryl und heteroaryl substituierte 4-pyridon-derivate verwendbar zur selektiven hemmung der blutgerinnungskaskade |
CA2405684A1 (en) | 2000-04-17 | 2001-10-25 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
AU2001222501A1 (en) * | 2000-05-18 | 2001-11-26 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
EP2177520A1 (de) * | 2000-06-12 | 2010-04-21 | Eisai R&D Management Co., Ltd. | 1,5-Di(aryl oder heteroaryl)-3-halo-2(1H)-pyridone als Zwischenverbindungen für die Herstellung von AMPA-Rezeptor-Hemmer |
US6943173B2 (en) * | 2000-07-18 | 2005-09-13 | Neurogen Corporation | 5-substituted 2-aryl-4-pyrimidinones |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
JP2004517074A (ja) | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類 |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
HUP0303631A2 (hu) * | 2000-12-26 | 2004-03-01 | Ono Pharmaceutical Co., Ltd. | Pirimidinszármazékok és eljárás előállításukra |
WO2003007964A1 (fr) * | 2001-07-18 | 2003-01-30 | Nippon Kayaku Kabushiki Kaisha | Remede ou agent preventif de cardiopathie ou d'anevrysme contenant un compose d'inhibition de la chymase |
EP1432687A2 (de) | 2001-10-03 | 2004-06-30 | Pharmacia Corporation | Substitutierte fünfgliedrige polyzyclischen vebindungen für die selektive hemmung der koagulationskaskade |
EP1438292A1 (de) | 2001-10-03 | 2004-07-21 | Pharmacia Corporation | 6-gliedrige heterocyclische verbindungen, die sich zur selektiven inhibierung der koagulationskaskade eignen |
GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
EP1553090A4 (de) * | 2002-06-14 | 2006-07-05 | Ajinomoto Kk | Verfahren zur herstellung einer pyrimidinverbindung |
PL373234A1 (en) * | 2002-07-30 | 2005-08-22 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Use of chymase inhibitors for the prevention and/or treatment of arterio-venous graft failure |
US20050176966A1 (en) * | 2003-04-11 | 2005-08-11 | Ajinomoto Co., Inc. | Process for the preparation of pyrimidine derivative, intermediate therefor and process for the preparation thereof |
PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
AU2004266536A1 (en) * | 2003-08-22 | 2005-03-03 | Teijin Pharma Limited | Drug containing chymase inhibitor as the active ingredient |
WO2005042499A1 (ja) * | 2003-11-04 | 2005-05-12 | Ajinomoto Co., Inc. | ピリミジン誘導体および中間体の製造方法 |
EP1533306A1 (de) * | 2003-11-04 | 2005-05-25 | Ajinomoto Co., Inc. | Azlactone und Verfahren zu deren Herstellung |
MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
ES2380632T3 (es) | 2004-11-24 | 2012-05-17 | Vertex Pharmceuticals Incorporated | Derivados de ácido3-(2-(3-ACILAMINO-2-OXO-2H-PIRIDIN)-ACETILAMINO)-4-OXO-PENTANOICO y su uso como inhibidores de caspasas |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
MY152078A (en) | 2007-09-14 | 2014-08-15 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones |
US8691849B2 (en) | 2008-09-02 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
RU2512283C2 (ru) | 2008-11-28 | 2014-04-10 | Янссен Фармасьютикалз, Инк. | Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов |
US8501749B2 (en) | 2009-01-30 | 2013-08-06 | Boehringer Ingelheim International Gmbh | Azaquinazolinediones chymase inhibitors |
PT2430022E (pt) | 2009-05-12 | 2013-12-26 | Janssen Pharmaceuticals Inc | Derivados de 1,2,3-triazolo[4,3-a]piridina e a sua utilização para o tratamento ou prevenção de doenças neurológicas e psiquiátricas |
EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
US8952024B2 (en) * | 2009-09-09 | 2015-02-10 | E I Du Pont De Nemours And Company | Herbicidal pyrimidone derivatives |
US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
US8993591B2 (en) | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
CN105873919A (zh) * | 2013-11-08 | 2016-08-17 | 拜耳医药股份有限公司 | 作为类糜蛋白酶抑制剂的取代的尿嘧啶 |
ME03518B (de) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung |
WO2015110435A1 (en) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
WO2016039936A2 (en) * | 2014-09-09 | 2016-03-17 | Ptc Therapeutics, Inc. | Monocyclic substituted 2-pyridinone antibacterial compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9207145D0 (en) * | 1991-04-18 | 1992-05-13 | Ici Plc | Heterocyclic amides |
GB9216272D0 (en) * | 1991-08-15 | 1992-09-09 | Ici Plc | Substituted heterocycles |
US5486529A (en) * | 1992-04-16 | 1996-01-23 | Zeneca Limited | Certain pyridyl ketones for treating diseases involving leukocyte elastase |
GB9307555D0 (en) * | 1992-04-16 | 1993-06-02 | Zeneca Ltd | Heterocyclic compounds |
US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
CA2186511C (en) * | 1994-03-31 | 2009-02-10 | Roland E. Dolle | Pyrimidinyl derivatives as interleukin inhibitors |
-
1996
- 1996-04-26 US US08/952,319 patent/US5948785A/en not_active Expired - Fee Related
- 1996-04-26 CA CA002219364A patent/CA2219364A1/en not_active Abandoned
- 1996-04-26 CN CNB001217976A patent/CN1188401C/zh not_active Expired - Fee Related
- 1996-04-26 WO PCT/JP1996/001171 patent/WO1996033974A1/ja active IP Right Grant
- 1996-04-26 KR KR1019970707522A patent/KR100400639B1/ko not_active IP Right Cessation
- 1996-04-26 CN CN96194926A patent/CN1131210C/zh not_active Expired - Fee Related
- 1996-04-26 DE DE69634122T patent/DE69634122D1/de not_active Expired - Lifetime
- 1996-04-26 EP EP96912273A patent/EP0826671B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1996033974A1 (fr) | 1996-10-31 |
CN1304931A (zh) | 2001-07-25 |
KR19990007998A (ko) | 1999-01-25 |
CN1188401C (zh) | 2005-02-09 |
EP0826671B1 (de) | 2004-12-29 |
CA2219364A1 (en) | 1996-10-31 |
EP0826671A1 (de) | 1998-03-04 |
US5948785A (en) | 1999-09-07 |
CN1131210C (zh) | 2003-12-17 |
CN1188472A (zh) | 1998-07-22 |
EP0826671A4 (de) | 1998-09-02 |
KR100400639B1 (ko) | 2003-12-31 |
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