DE69634122D1 - Heterocyclische amidverbindungen und deren medizinische verwendung - Google Patents

Heterocyclische amidverbindungen und deren medizinische verwendung

Info

Publication number
DE69634122D1
DE69634122D1 DE69634122T DE69634122T DE69634122D1 DE 69634122 D1 DE69634122 D1 DE 69634122D1 DE 69634122 T DE69634122 T DE 69634122T DE 69634122 T DE69634122 T DE 69634122T DE 69634122 D1 DE69634122 D1 DE 69634122D1
Authority
DE
Germany
Prior art keywords
medicine
amide compounds
heterocyclic amide
heterocyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634122T
Other languages
English (en)
Inventor
Fumihiko-The Green Cr Akahoshi
Takuya-The Green Cro Yoshimura
Masahiro-The Green Cross C Eda
Atsuyuki-The Green Cr Ashimori
Hajime-The Green Cros Fukuyama
Masahide-The Green Cr Nakajima
Teruaki-The Green Cross Imada
Hideki Okunishi
Mizuo Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of DE69634122D1 publication Critical patent/DE69634122D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69634122T 1995-04-27 1996-04-26 Heterocyclische amidverbindungen und deren medizinische verwendung Expired - Lifetime DE69634122D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10431495 1995-04-27
PCT/JP1996/001171 WO1996033974A1 (fr) 1995-04-27 1996-04-26 Composes heterocycliques amides et leur utilisation medicinale

Publications (1)

Publication Number Publication Date
DE69634122D1 true DE69634122D1 (de) 2005-02-03

Family

ID=14377479

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634122T Expired - Lifetime DE69634122D1 (de) 1995-04-27 1996-04-26 Heterocyclische amidverbindungen und deren medizinische verwendung

Country Status (7)

Country Link
US (1) US5948785A (de)
EP (1) EP0826671B1 (de)
KR (1) KR100400639B1 (de)
CN (2) CN1188401C (de)
CA (1) CA2219364A1 (de)
DE (1) DE69634122D1 (de)
WO (1) WO1996033974A1 (de)

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JP2002513412A (ja) 1997-04-14 2002-05-08 シーオーアール セラピューティクス インコーポレイテッド 選択的Xa因子阻害剤
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AU6896398A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
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JP3923255B2 (ja) * 1998-07-15 2007-05-30 帝人株式会社 チオベンズイミダゾール誘導体
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US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
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US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
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EP1224945A4 (de) * 1999-10-25 2004-08-18 Senju Pharma Co Mittel zur linderung der ziliarmuskelspannung
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EP1174151B1 (de) 2000-02-22 2007-01-24 Daiichi Asubio Pharma Co., Ltd. Therapeutische behandlung von eosinophilie durch verwendung von chymase-inhibitoren als aktiven bestandteilen
DE60121695T2 (de) 2000-02-22 2007-08-30 Daiichi Asubio Pharma Co., Ltd. Arzneimittel mit chymaseinhibitoren als wirksames mittel zur behandlung von dermatitis mit zweiphasigen hautreaktionen
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US6660885B2 (en) 2000-03-13 2003-12-09 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
DE60108948T2 (de) 2000-04-05 2005-11-03 Pharmacia Corp. Polyzyclisch aryl und heteroaryl substituierte 4-pyronen verwendbar als selektive hemmung von dem koagulationsprozess
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CA2405684A1 (en) 2000-04-17 2001-10-25 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
AU2001222501A1 (en) * 2000-05-18 2001-11-26 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
EP2177520A1 (de) * 2000-06-12 2010-04-21 Eisai R&D Management Co., Ltd. 1,5-Di(aryl oder heteroaryl)-3-halo-2(1H)-pyridone als Zwischenverbindungen für die Herstellung von AMPA-Rezeptor-Hemmer
US6943173B2 (en) * 2000-07-18 2005-09-13 Neurogen Corporation 5-substituted 2-aryl-4-pyrimidinones
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US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
HUP0303631A2 (hu) * 2000-12-26 2004-03-01 Ono Pharmaceutical Co., Ltd. Pirimidinszármazékok és eljárás előállításukra
WO2003007964A1 (fr) * 2001-07-18 2003-01-30 Nippon Kayaku Kabushiki Kaisha Remede ou agent preventif de cardiopathie ou d'anevrysme contenant un compose d'inhibition de la chymase
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EP1438292A1 (de) 2001-10-03 2004-07-21 Pharmacia Corporation 6-gliedrige heterocyclische verbindungen, die sich zur selektiven inhibierung der koagulationskaskade eignen
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US20050176966A1 (en) * 2003-04-11 2005-08-11 Ajinomoto Co., Inc. Process for the preparation of pyrimidine derivative, intermediate therefor and process for the preparation thereof
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CN105873919A (zh) * 2013-11-08 2016-08-17 拜耳医药股份有限公司 作为类糜蛋白酶抑制剂的取代的尿嘧啶
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CA2186511C (en) * 1994-03-31 2009-02-10 Roland E. Dolle Pyrimidinyl derivatives as interleukin inhibitors

Also Published As

Publication number Publication date
WO1996033974A1 (fr) 1996-10-31
CN1304931A (zh) 2001-07-25
KR19990007998A (ko) 1999-01-25
CN1188401C (zh) 2005-02-09
EP0826671B1 (de) 2004-12-29
CA2219364A1 (en) 1996-10-31
EP0826671A1 (de) 1998-03-04
US5948785A (en) 1999-09-07
CN1131210C (zh) 2003-12-17
CN1188472A (zh) 1998-07-22
EP0826671A4 (de) 1998-09-02
KR100400639B1 (ko) 2003-12-31

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