DE69633717T2 - Monoklonale anti-cd6 antikörper zur behandlung und diagnose von psoriasis - Google Patents
Monoklonale anti-cd6 antikörper zur behandlung und diagnose von psoriasis Download PDFInfo
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- DE69633717T2 DE69633717T2 DE69633717T DE69633717T DE69633717T2 DE 69633717 T2 DE69633717 T2 DE 69633717T2 DE 69633717 T DE69633717 T DE 69633717T DE 69633717 T DE69633717 T DE 69633717T DE 69633717 T2 DE69633717 T2 DE 69633717T2
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- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
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- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 229940126622 therapeutic monoclonal antibody Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/20—Dermatological disorders
- G01N2800/205—Scaling palpular diseases, e.g. psoriasis, pytiriasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU12095 | 1995-11-17 | ||
| CU1995120A CU22584A1 (es) | 1995-11-17 | 1995-11-17 | Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis |
| PCT/CU1996/000004 WO1997019111A2 (es) | 1995-11-17 | 1996-11-18 | Anticuerpos monoclonales anti-cd6 y sus utilizaciones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69633717D1 DE69633717D1 (de) | 2004-12-02 |
| DE69633717T2 true DE69633717T2 (de) | 2006-02-02 |
Family
ID=5459401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69633717T Expired - Lifetime DE69633717T2 (de) | 1995-11-17 | 1996-11-18 | Monoklonale anti-cd6 antikörper zur behandlung und diagnose von psoriasis |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6572857B1 (enExample) |
| EP (1) | EP0807125B1 (enExample) |
| JP (1) | JP4113929B2 (enExample) |
| KR (1) | KR100533854B1 (enExample) |
| CN (1) | CN1222540C (enExample) |
| AT (1) | ATE280783T1 (enExample) |
| AU (1) | AU722882B2 (enExample) |
| BR (1) | BRPI9607171B1 (enExample) |
| CA (1) | CA2210751C (enExample) |
| CU (1) | CU22584A1 (enExample) |
| DE (1) | DE69633717T2 (enExample) |
| DK (1) | DK0807125T3 (enExample) |
| ES (1) | ES2231826T3 (enExample) |
| PT (1) | PT807125E (enExample) |
| WO (1) | WO1997019111A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030215450A1 (en) * | 2000-05-26 | 2003-11-20 | Blake Simon M | Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders |
| CU23097A1 (es) | 2002-10-23 | 2005-11-18 | Centro Inmunologia Molecular | Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método |
| CA2516971A1 (en) | 2003-02-24 | 2004-09-02 | Institut Pasteur | Secreted chlamydia polypeptides, polynucleotides coding therefor, therapeutic and diagnostic uses thereof |
| CA2676185C (en) * | 2006-12-26 | 2013-03-12 | Centro De Inmunologia Molecular | Pharmaceutical composition, comprising an anti-cd6 monoclonal antibody used in the diagnosis and treatment of rheumatoid arthritis |
| CN101678101B (zh) | 2006-12-26 | 2012-11-07 | 分子免疫中心 | 可用于诊断和治疗b细胞慢性淋巴细胞白血病的能够在肿瘤细胞中诱导凋亡的药物组合物 |
| MX2010007551A (es) | 2008-01-11 | 2010-11-30 | Synovex Corp | Antagonistas de la cadherina-11 y metodos para el tratamiento de trastornos inflamatorios de las articulacion. |
| EP2993186B1 (en) * | 2008-03-14 | 2019-09-04 | Biocon Limited | A monoclonal antibody and a method thereof |
| BR112013001062A2 (pt) * | 2010-07-15 | 2016-05-24 | Synovex Corp | anticorpos humanizados que visam o domínio ec1 de caderina-11 e composições e métodos relacionados |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2821992A1 (en) | 2010-10-01 | 2012-04-05 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| BR112013033988B1 (pt) | 2011-07-01 | 2021-10-19 | Beckman Coulter, Inc. | Métodos de identificação e isolamento de uma ou mais populações de células t regulatórias imunossupressoras |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| HRP20220250T1 (hr) | 2011-10-03 | 2022-04-29 | Modernatx, Inc. | Modificirani nukleozidi, nukleotidi i nukleinske kiseline, te njihove uporabe |
| SI2791160T1 (sl) | 2011-12-16 | 2022-07-29 | Modernatx, Inc. | Sestave modificirane MRNA |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| AU2013243952A1 (en) | 2012-04-02 | 2014-10-30 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| SMT202200337T1 (it) | 2012-11-26 | 2022-09-14 | Modernatx Inc | Rna modificato al livello del terminale |
| FR3000216B1 (fr) * | 2012-12-21 | 2015-02-06 | Galderma Res & Dev | Utilisation de proteases particulieres pour la detection de trichophytons et de pathologies associees |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP3936148A1 (en) | 2013-07-23 | 2022-01-12 | Biocon Limited | Use of a cd6 binding partner and method based thereon |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| CN105504062B (zh) * | 2015-12-25 | 2019-06-04 | 百泰生物药业有限公司 | 一种抗CD6单抗T1h的检测性抗体及应用 |
| EP3529274B1 (en) | 2016-10-21 | 2024-04-17 | Biocon Limited | A monoclonal antibody and a method of use for the treatment of lupus |
| AU2019228508A1 (en) * | 2018-02-27 | 2020-09-17 | Equillium, Inc. | Anti CD6 antibodies for treating severe asthma |
| WO2020006568A1 (en) | 2018-06-29 | 2020-01-02 | City Of Hope | Cd6 targeted chimeric antigen receptors for treatent of certain autoimmune disorders |
| EP3930751A1 (en) | 2019-02-26 | 2022-01-05 | Equillium, Inc. | Anti-cd6 antibody compositions and methods for treating lupus |
| EP4084808A1 (en) | 2019-12-30 | 2022-11-09 | City of Hope | Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers |
| CA3231281A1 (en) | 2021-09-08 | 2023-03-16 | Yanelda De Los Angeles Garcia Vega | Use of anti-cd6 monoclonal antibodies in the prevention of cellular and organ damage resulting from hyper-inflammatory response |
| WO2025096685A1 (en) | 2023-10-30 | 2025-05-08 | City Of Hope | Methods of making and using regulatory t cells for treatment of autoimmune disorders and cancers |
| CN120005027B (zh) * | 2025-04-10 | 2025-09-23 | 中国水产科学研究院长江水产研究所 | 大口黑鲈cd6抗原结合肽、及其单克隆抗体和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995012614A1 (en) * | 1993-11-02 | 1995-05-11 | Duke University | Cd6 ligand |
| CU22615A1 (es) * | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
-
1995
- 1995-11-17 CU CU1995120A patent/CU22584A1/es unknown
-
1996
- 1996-11-18 PT PT96939805T patent/PT807125E/pt unknown
- 1996-11-18 US US08/875,674 patent/US6572857B1/en not_active Expired - Lifetime
- 1996-11-18 BR BRPI9607171A patent/BRPI9607171B1/pt not_active IP Right Cessation
- 1996-11-18 EP EP96939805A patent/EP0807125B1/en not_active Expired - Lifetime
- 1996-11-18 AT AT96939805T patent/ATE280783T1/de active
- 1996-11-18 DE DE69633717T patent/DE69633717T2/de not_active Expired - Lifetime
- 1996-11-18 ES ES96939805T patent/ES2231826T3/es not_active Expired - Lifetime
- 1996-11-18 CA CA002210751A patent/CA2210751C/en not_active Expired - Lifetime
- 1996-11-18 DK DK96939805T patent/DK0807125T3/da active
- 1996-11-18 JP JP51926797A patent/JP4113929B2/ja not_active Expired - Lifetime
- 1996-11-18 WO PCT/CU1996/000004 patent/WO1997019111A2/es not_active Ceased
- 1996-11-18 CN CNB96192098XA patent/CN1222540C/zh not_active Expired - Lifetime
- 1996-11-18 KR KR1019970704893A patent/KR100533854B1/ko not_active Expired - Lifetime
- 1996-11-18 AU AU76905/96A patent/AU722882B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997019111A2 (es) | 1997-05-29 |
| JPH11506017A (ja) | 1999-06-02 |
| DK0807125T3 (da) | 2005-03-14 |
| JP4113929B2 (ja) | 2008-07-09 |
| CA2210751C (en) | 2007-01-30 |
| BRPI9607171B1 (pt) | 2016-07-19 |
| US6572857B1 (en) | 2003-06-03 |
| KR100533854B1 (ko) | 2006-09-20 |
| MX9705445A (es) | 1998-06-30 |
| PT807125E (pt) | 2005-03-31 |
| WO1997019111A3 (es) | 1998-02-12 |
| CN1222540C (zh) | 2005-10-12 |
| CN1175957A (zh) | 1998-03-11 |
| BR9607171A (pt) | 1997-11-11 |
| ATE280783T1 (de) | 2004-11-15 |
| KR19980701502A (ko) | 1998-05-15 |
| ES2231826T3 (es) | 2005-05-16 |
| EP0807125B1 (en) | 2004-10-27 |
| AU722882B2 (en) | 2000-08-10 |
| DE69633717D1 (de) | 2004-12-02 |
| CU22584A1 (es) | 1999-11-03 |
| EP0807125A2 (en) | 1997-11-19 |
| CA2210751A1 (en) | 1997-05-29 |
| AU7690596A (en) | 1997-06-11 |
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| 8364 | No opposition during term of opposition |