DE69628576T2 - Procollagene - Google Patents

Procollagene Download PDF

Info

Publication number
DE69628576T2
DE69628576T2 DE69628576T DE69628576T DE69628576T2 DE 69628576 T2 DE69628576 T2 DE 69628576T2 DE 69628576 T DE69628576 T DE 69628576T DE 69628576 T DE69628576 T DE 69628576T DE 69628576 T2 DE69628576 T2 DE 69628576T2
Authority
DE
Germany
Prior art keywords
collagen
proα1
chain
proα2
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69628576T
Other languages
German (de)
English (en)
Other versions
DE69628576D1 (de
Inventor
Neil Didsbury BULLEID
Karl Marple KADLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Manchester Manchester Gb, University of
Original Assignee
Victoria University of Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9517773.9A external-priority patent/GB9517773D0/en
Priority claimed from GBGB9606152.8A external-priority patent/GB9606152D0/en
Priority claimed from GBGB9612476.3A external-priority patent/GB9612476D0/en
Application filed by Victoria University of Manchester filed Critical Victoria University of Manchester
Publication of DE69628576D1 publication Critical patent/DE69628576D1/de
Application granted granted Critical
Publication of DE69628576T2 publication Critical patent/DE69628576T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C1/00—Photosensitive materials
    • G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
    • G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
    • G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Body Structure For Vehicles (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69628576T 1995-08-31 1996-08-30 Procollagene Expired - Lifetime DE69628576T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9517773.9A GB9517773D0 (en) 1995-08-31 1995-08-31 Novel procollagens
GB9517773 1995-08-31
GB9606152 1996-03-23
GBGB9606152.8A GB9606152D0 (en) 1996-03-23 1996-03-23 Novel procollagens
GBGB9612476.3A GB9612476D0 (en) 1996-06-14 1996-06-14 Novel procollagens
GB9612476 1996-06-14
PCT/GB1996/002122 WO1997008311A1 (en) 1995-08-31 1996-08-30 Novel procollagens

Publications (2)

Publication Number Publication Date
DE69628576D1 DE69628576D1 (de) 2003-07-10
DE69628576T2 true DE69628576T2 (de) 2004-04-22

Family

ID=27267880

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69628576T Expired - Lifetime DE69628576T2 (de) 1995-08-31 1996-08-30 Procollagene

Country Status (11)

Country Link
US (1) US6171827B1 (https=)
EP (1) EP0859838B1 (https=)
JP (1) JP4003836B2 (https=)
AT (1) ATE242325T1 (https=)
AU (1) AU724706B2 (https=)
CA (1) CA2230556C (https=)
DE (1) DE69628576T2 (https=)
DK (1) DK0859838T3 (https=)
ES (1) ES2201193T3 (https=)
PT (1) PT859838E (https=)
WO (1) WO1997008311A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
GB9704305D0 (en) * 1997-03-01 1997-04-23 Univ Manchester Procollagen assembly
US6022694A (en) * 1997-04-04 2000-02-08 Regeneron Pharmaceuticals, Inc. Assay for ligands to tyrosine kinase receptors
EP0913692A1 (en) * 1997-10-31 1999-05-06 Bayer Ag An immunoassay for procollagen-III-C-terminal propeptide
US6428978B1 (en) 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
JP2000125872A (ja) * 1998-09-07 2000-05-09 Terumo Corp 三量体キメラタンパク質およびキメラタンパク質を含有するコラーゲンマトリックス
DE10053870A1 (de) * 2000-10-31 2002-05-08 Burchardt Elmar Reinhold Procollagen (III)-Propeptide und verwandte Substanzen zur Behandlung von fibrotischen Erkrankungen
CN1196712C (zh) * 2001-02-21 2005-04-13 范代娣 一种类人胶原蛋白及其生产方法
GB0309064D0 (en) * 2003-04-22 2003-05-28 Univ Manchester Modified peptides and their uses
US7268116B2 (en) * 2003-10-02 2007-09-11 Genhunter Corp. Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins
US9095569B2 (en) * 2008-04-18 2015-08-04 Collplant Ltd. Methods of generating and using procollagen
CN101601858B (zh) 2009-05-27 2012-09-19 上海交通大学 中期因子蛋白的用途及含该蛋白的医用装置
US9725498B2 (en) 2009-07-17 2017-08-08 The Texas A&M University System Designer collagens and use thereof
EP2454367B1 (en) * 2009-07-17 2013-10-16 The Texas A&M University System Designer collagens and uses thereof
WO2013072504A1 (en) * 2011-11-16 2013-05-23 Centre National De La Recherche Scientifique (Cnrs) Crystal structure of the procollagen iii c-propeptide trimer and applications thereof
CN104884468B (zh) * 2012-12-28 2018-08-31 国立大学法人大阪大学 附加有胶原结合性分子的改造层粘连蛋白及其利用
US11377490B2 (en) 2017-05-31 2022-07-05 Sichuan Clover Biopharmaceuticals, Inc Method for treating cancer using disulfide-linked trimeric 4-1BBL
WO2019098246A1 (ja) * 2017-11-14 2019-05-23 国立大学法人筑波大学 改変されたコラーゲンタンパク質およびその用途
WO2021249116A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Coronavirus vaccine compositions, methods, and uses thereof
WO2021249011A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Hiv vaccine compositions, methods, and uses thereof
WO2022041760A1 (en) 2020-08-31 2022-03-03 Sichuan Clover Biopharmaceuticals, Inc. Methods and compositions for purification of trimeric fusion proteins
CN116813749B (zh) * 2023-06-13 2024-01-30 广州启点生物科技有限公司 一种重组人源化iii型胶原蛋白及其制备方法和应用
EP4711378A1 (en) * 2024-09-12 2026-03-18 AcroPharma AB Peptide agonists of gpr56

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU84485A1 (fr) 1982-11-22 1984-06-13 Oreal Nouvelle composition anti-acneique a base de peroxyde de benzoyle et d'au moins un autre principe actif
GB9014220D0 (en) 1990-06-26 1990-08-15 Farmos Yhtymy Oy Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen
US5424408A (en) * 1990-11-30 1995-06-13 Yale University α-3 chain type IV collagen polynucleotides
JP3302017B2 (ja) * 1991-10-23 2002-07-15 トーマス・ジェファーソン・ユニバーシティ 組み換えｄｎａ合成システムにおけるヒトプロコラーゲン及びコラーゲンの合成
US5667839A (en) * 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals

Also Published As

Publication number Publication date
JP4003836B2 (ja) 2007-11-07
CA2230556A1 (en) 1997-03-06
EP0859838B1 (en) 2003-06-04
ES2201193T3 (es) 2004-03-16
AU6832696A (en) 1997-03-19
PT859838E (pt) 2003-10-31
ATE242325T1 (de) 2003-06-15
DE69628576D1 (de) 2003-07-10
WO1997008311A1 (en) 1997-03-06
JP2000506362A (ja) 2000-05-30
DK0859838T3 (da) 2003-10-06
CA2230556C (en) 2011-06-07
EP0859838A1 (en) 1998-08-26
US6171827B1 (en) 2001-01-09
AU724706B2 (en) 2000-09-28

Similar Documents

Publication Publication Date Title
DE69628576T2 (de) Procollagene
DE69434423T2 (de) Herstellung von menschlichem rekombinantem kollagen in der milch eines transgen-tieres
EP0835939B1 (de) Fusionsproteine mit Immunglobulinanteilen, ihre Herstellung und Verwendung
DE69434053T2 (de) Verkürzter keratinocytenwachstumsfaktor(kgf)mit erhöhter biologischer aktivität
EP0769020B1 (de) NEUE hIL-4-MUTANTENPROTEINE ALS ANTAGONISTEN ODER PARTIELLE AGONISTEN DES HUMANEN INTERLEUKIN 4
DE69434651T2 (de) Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
DE69836217T2 (de) Chimäres lösliches interleukin-6 rezeptor/ligand protein, analoge und verwendungen
DE69933216T2 (de) Erythropoietin-analog-menschliches serum-albumin fusionsprotein
DE69918946T2 (de) Rezeptoren für il-18
DE69002395T2 (de) N-terminale Fragmente von menschliches Serumalbumin enthaltenden Fusionsproteinen.
DE60224822T2 (de) Dimerisierter wachstumsfaktor sowie materialien und verfahren zu seiner herstellung
JPH02500241A (ja) 新規骨誘導組成物
DE68928203T2 (de) Rekombinante dns-moleküle, wirte und dem menschlichen somatomedin-trägerprotein ähnliche polypeptide
DE19605657A1 (de) Proinsulinderivat und Verfahren zur Herstellung von menschlichem Insulin
DE69532436T2 (de) Einzelkettenformen des clycoprotein-hormon-quartetts
EP1151095B1 (de) Polypeptidvarianten mit erhoehter heparin-bindungsfaehigkeit
DE69133338T2 (de) Bmp-5-derivate
DE69924009T2 (de) Methode zur verstärkung der biologischen aktivität von liganden
DE69937570T2 (de) Transformierender wachstumsfaktor beta-9 (ztgfss9) aus säugetieren
DE69938579T2 (de) Extrazelluläre Matrixproteine mit modifizierten Aminosäuren
DE102021202830A1 (de) Rekombinantes Typ II-Kollagen zur therapeutischen Verwendung
DE69033603T2 (de) Antagonisten von wachstumshormonen
DE69131979T2 (de) Genetisches igfbp-4 rodierendes material
DE69233155T2 (de) Insulinartigen wachstumsfaktor bindendes protein
DE68923496T2 (de) Verfahren zur Herstellung von motilinähnlichen Polypeptiden und seine Expression.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: THE UNIVERSITY OF MANCHESTER, MANCHESTER, GB

8328 Change in the person/name/address of the agent

Representative=s name: PATENTANWAELTE ZELLENTIN & PARTNER GBR, 81667 MUENCHEN