WO2013072504A1 - Crystal structure of the procollagen iii c-propeptide trimer and applications thereof - Google Patents

Abstract

The present invention relates to a crystal comprising a procollagen III C- propeptide trimer and to a method for producing said crystal. The present invention also provides methods for identifying compounds modulating the trimerization of procollagen III C-propeptide trimer, or modulating the binding of procollagen C- proteinase enhancer 1 (PCPE1) to said trimer.

Description

CRYSTAL STRUCTURE OF THE PROCOLLAGEN III C-PROPEPTIDE TRIMER

AND APPLICATIONS THEREOF INTRODUCTION

The present invention relates to a crystal comprising a procollagen I I I C- propeptide trimer and to a method for producing said crystal. The present invention also provides methods for identifying compounds modulating the trimerization of procollagen I I I C-propeptide trimer, or modulating the binding of procollagen C- proteinase enhancer 1 (PCPE1 ) to said trimer.

Fibrillar collagens (types I , I I , I I I , V, XI) account for approximately 25 % of protein mass in the body, where they occur in the form of banded fibrils with a characteristic 64-67 nm periodicity. These collagens are synthesized in precursor form, procollagen (~ 450 kDa), as rod-like molecules (length ~ 300 nm) with globular N- and C-term i nal propeptide extensions (-50 kDa a nd 90 kDa , respectively). Each procollagen molecule consists of three polypeptide chains.

Inside the cell, procollagen molecular assembly is initiated by trimerization of C- propeptide domains (Boudko et al., 2012), followed by zipper-like folding towards the N-terminal end . Tri merization is a h igh ly specific process, lead i ng to correct association of the polypeptide chains into heterotrimers (procollagens I , V and XI) or homotrimers (procollagens II and III) and also preventing incorrect association of different genetic types. The importance of the C-propeptides in procollagen trimerization is underlined by the large number of heritable disorders of connective tissue that are characterized by mutations in this region of the molecule (Bateman et al. , 2009), which affect several tissues, including bone, cartilage, skin and blood vessels (Chessler et al., 1993; Pace et al., 2002; Nishimura et al., 2005; De Paepe et al., 1997; Pickup & Pollanen, 201 1 ).

In addition to its intracellular function in molecular trimerization, another crucial role for the C-propeptide is to confer solubility to the collagen molecule, thereby controlling fibril formation (Kadler et al., 1996; Canty et al., 2005) (Figure 1 1 ). Thus, outside the cell or during intracellular transport and secretion, C-propeptide trimers are released (in the case of procollagens l-l l l) by BMP-1/tolloid-like proteinases (Muir et al., 201 1 ), this being the rate limiting step in collagen fibril assembly. C-propeptide cleavage is further regulated by procollagen C-proteinase enhancer (PCPE) proteins, which bind specifically to the C-propeptides (Vadon-Le Goff et al., 201 1 ). Since excess collagen deposition is the hallmark of several fibrotic disorders (affecting heart, lung, liver, etc) which together are leading causes of morbidity and mortality worldwide (Wynn, 2007), structural data on the C-propeptide trimer are clearly essential for the development of new therapeutic strategies. Free C-propeptide trimers are also involved in feedback inhibition of collagen synthesis (Mizuno et al., 2000; Wu et al. , 1991 ), via interaction with integrins (Davies et al., 1997), as well as in biomineralisation (Kirsch and Pfaffle, 1992; Van der Rest et al., 1986; Lee et al., 1996; Lindahl et al., 201 1 ), in angiogenesis and tumour progression (Palmieri et al., 2008; Vincourt et al., 2010).

The C-propeptides of fibrillar procollagens thus play crucial roles in tissue homeostasis and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils, as well as in a number of diseases.

However, despite their obvious biomedical importance, and many years of research since the C-propeptide trimers discovery in 1972, the high resolution three- dimensional structures of the fibrillar procollagen C-propeptides have until now remained elusive. So far, only a low resolution structural analysis of the C-propeptide trimer from procollagen I I I has been achieved by smal l angle X-ray scattering (Bernocco et al., 2001 ). Furthermore, because there are no known homologous proteins for which three-dimensional structures are available, molecular modeling by homology is precluded.

There is therefore an urgent need in the art to provide a crystal structure of the procollagens C-propeptide trimers and elucidate the high resolution three-dimensional structures of said trimers, and to use said structures in therapeutic strategies, such as drug design and/or to identify compounds capable of modulating the assembly of procollagen (e.g. by modulating the trimerization of a procollagen C-propeptide), or the assembly of collagen fibrils (e.g. by modulating the binding of PCPE to a procollagen C-propeptide trimer). The object of the present invention is to do so for the procollagen I I I C-propeptide (CPIII). Procollagen I II is of particular interest as it can be found in high quantity in young tissue, such as in the early phases of wound healing or during the initial phase of development of a fibrosis. Furthermore, procollagen III C-propeptide forms homotrimers: its three-dimensional structure may thus be used to determine the structure of other homotrimeric or heterotrimeric procollagen propeptides.

The inventors report here the production, on a large scale and with a high degree of purity, and the crystallization, after 12 years of research, of the C-propeptide trimer from human procollagen I I I in both its native and selenomethionine-labeled forms, resulting in X-ray diffraction data to a resolution of up to 1 .7A, thus heralding the first molecular structure determination for this important protein domain . The inventors further report the identification of critical amino acid residues playing a key role in the procollagen assembly and in procollagen propeptide cleavage. DETAILED DESCRIPTION OF THE INVENTION

So in a first aspect, the present invention is directed to a crystal comprising or consisting of a procollagen III C-propeptide trimer, preferably originating from human.

The term "procollagen" as used herein, refers the inactive precursor form of a mature collagen molecule that comprises an N-terminal propeptide and a C-terminal propeptide.

The term "procollagen C-propeptide" (CP) refers to the C-terminal proteolytic fragment resulting from the cleavage of procollagen by specific cell endoproteases, such as BMP-1 (bone morphogenetic protein-1 ) and tolloid-like proteinases. In the context of the present invention, the terms procollagen III C-propeptide or CPIII may be used interchangeably.

The term "procollagen C-propeptide trimer" more particularly refers to the three CP monomeric subunits (i.e. CP monomers) linked together by intermolecular disulfide bridges, so as to form a procollagen C-propeptide. The terms "procollagen C- propeptide homotrimer" thus refer to three identical CP monomeric subunits linked together by intermolecular disulfide bridges, so as to form a procollagen C-propeptide. In the context of the present invention, the procollagen III C-propeptide trimer consists of [a1 (lll)]3 homotrimers (i.e. of three identical monomers of a1 chain), and may be referred herein as CPIII trimer.

In a preferred embodiment, a monomer of said procollagen III C-propeptide trimer is of sequence selected from SEQ ID N°1 , SEQ ID N°2, SEQ ID N°6 and mutated sequences thereof. More preferably, said monomer is of sequence SEQ ID N°2 and mutated sequences thereof.

As used herein, by "mutated sequence", it is meant an amino acid sequence which comprises deletion(s), addition(s) or substitution(s) of amino acid(s), but still retains all the essential characteristics of the protein of reference, i.e. in the context of the invention, retains at least the structural characteristics of the crystal (such as atomic coordinates) with acceptable standard variations. A mutated sequence may be made, for example, by mutagenesis techniques on the nucleic acid encoding the protein of reference, such as site-directed mutagenesis.

Preferably, a monomer of said procollagen III C-propeptide trimer as described above is mutated at at least one N-glycosylation site. Indeed, this type of mutation prevents the N-glycosylation to occur when producing a protein of interest in a recombinant host cell, thereby blocking the formation of N-glycans which may affect the ability of the protein to form well diffracting crystals. More preferably, said monomer contains the mutation N146Q in sequence SEQ ID N°1 , or the mutation N157Q in sequence SEQ ID N°2 or SEQ ID N°6.

In yet another preferred embodiment, the crystal as described above has the following parameters:

a) space group is P2₁2₁2₁, unit cell parameters are a = 76.5 A; b = 90.4 A, c =102.4 A, α β and γ= 90.0 degrees, and one procollagen III C-propeptide trimer is included in an asymmetric unit (crystal a), or

b) space group is P321 , unit cell parameters are a = 86.1 A; b = 86.1 A, c = 73 A, a and β = 90.0 degrees and γ= 120.0 degrees, and one monomer of said procollagen III C-propeptide trimer is included in an asymmetric unit (crystal b), or

c) space group is P2₁2₁2_1-Se, unit cell parameters are a = 83.9 A; b = 89.3 A, c =101.5 A, α β and γ= 90.0 degrees, and one procollagen III C-propeptide trimer is included in an asymmetric unit, said procollagen III C-propeptide being selenomethionylated (crystal c).

As used herein, a "unit cell" refers to the smallest repeating unit of a crystal and is defined by three cell edges (a, b, c in A), and three angles (α β and γ, in degrees) between each pair of edges. Each unit cell may contain one or more protein molecules related by crystal symmetry. The unique portion of the unit cell, i.e., the portion that is not related to other portions by crystal symmetry is the "assymetric unit". A "space group", or "three dimensional space group", means herein a particular combination of symmetry elements in a crystal among the 230 existing possible combinations (Hahn, 2006).

More preferably, crystal a and b refer to a crystal as described above in its native form, while crystal c refers to a crystal as described above in a selenomethionine-labeled form. Selenomethionine (Se-Met) labelling may indeed be useful to elucidate the structure of a protein by X-ray crystallography using for example single or multi-wavelength anomalous dispersion (SAD or MAD), notably in the absence of a crystal structure of homologous proteins.

It is thus an advantageous embodiment of the invention to provide:

a) a crystal a) as described above, wherein the atomic coordinates are defined in Table A; or b) a crystal b) as described above, wherein the atomic coordinates are defined in Table B, or

c) a crystal c) as described above, wherein the atomic coordinates are defined in Table C.

The term "atomic coordinates" as used herein, refers to Cartesian coordinates derived from mathematical equations and corresponding to an atom's spatial relationship to other atoms in a molecule (such as a protein) or molecular complex. These atomic coordinates thus provide information of the three-dimensional (3D) molecular structure of a given molecule, and are preferably reported in a pdb ("protein data bank") format for macromolecules such as proteins (see http://www.wwpdb.org/docs.html). Atomic coordinates can also be used to obtain structural information about another crystallized molecule or molecular complex, such as by molecular replacement, or to obtain structural information about another non- crystallized molecule or molecular complex, such as by homology modeling.

According to another particular embodiment of the invention, in the crystal as described above, said procollagen III C-propeptide trimer is further complexed with the CUB1 CUB2 domains of Procollagen C-proteinase Enhancer 1 (PCPE1 ). Preferably, said CUB1 CUB2 domains of Procollagen C-proteinase Enhancer 1 (PCEP1 ) are of sequence selected from SEQ ID N°3 and SEQ ID N°4. As used herein, CUB stands for complement C1 r/C1 s, Uegf, Bmp1.

Methods for obtaining said crystal and for using the structure of said crystal are described further below.

It is another aspect of the invention to provide a set of crystals a), b) and c) as described above, preferably a set of crystals a), b) and c) wherein the atomic coordinates are as set forth in Tables A, B and C. Those skilled in the art will readily understand that the set of atomic coordinates defines the overall three-dimensional structure of the CPU I trimer.

In yet another aspect, the invention is related to a method for producing a crystal comprising or consisting of a procollagen III C-propeptide trimer as described above, said method comprising the following steps:

a) providing a protein solution comprising or consisting of a procollagen III C-propeptide trimer, wherein a monomer of procollagen III C- propeptide is of sequence selected from SEQ ID N°1 , SEQ ID N°2, SEQ ID N°6 and mutated sequences thereof ; b) subjecting said protein solution to conditions which promote optimal crystallization.

According to a preferred embodiment of the above method, for providing a protein solution comprising or consisting of said procollagen III C-propeptide trimer, step a) comprises the following steps:

i) cloning a nucleic acid encoding a monomer of procollagen III C- propeptide as described above, into a recombinant expression vector ; ii) transforming a recombinant host cell with said vector ;

iii) expressing said monomer from said host cell, so as to obtain a trimer of procollagen III C-propeptide; and

iv) purifying said procollagen III C-propeptide trimer.

The terms "vector" and "plasmid" as used herein relate to the same tool which is useful for performing procedures of molecular biology and genetic recombination. A "recombinant expression vector" as used herein more particularly refers to a vector that enables the expression of a protein encoded by a nucleic acid of interest which is inserted in said vector. Such vectors are commonly used and very well known in the art. Techniques for inserting (i.e. cloning) a nucleic acid of interest into vectors are described in several well known references such as Sambrook et al. (2001 ) and Ausubel et al. (201 1 ).

A preferred recombinant expression vector according to the invention is the pHLsec vector. This vector allows for high level expression of a protein of interest (Aricescu et al., 2006).

A recombinant vector according to the invention is advantageously contained into a recombinant host cell, which allows the expression of the CPU I trimer, or a complex thereof.

As used herein, the terms "host cell", "cell" or "cell line", thus refer to a prokaryotic or a eukaryotic cell in which the recombinant vector of the invention can be introduced, so as to express a protein of interest. To this end, a host cell may be "transfected" or "transformed" by a process well known to those skilled in the art by which said vector is transferred or introduced into the host cell. Examples of such methods include, without limitation, electroporation, lipofection, calcium phosphate transfection, and transfection using DEAE dextran. The skilled person will be able to choose the appropriate host cell among the many cell lines that are publicly available, notably via the American Type Culture Collection (ATCC) (www.ATCC.org). The host cell according to the invention may preferably be a N-glycosylation-deficient host cell, more particularly if the monomer of said procollagen III C-propeptide trimer as described above is not mutated at N-glycosylation site(s).

Preferred recombinant host cells according to the invention are mammalian cells and baculorivus-infected insect cells. A more particularly preferred mammalian recombinant host cell according to the invention is the HEK293T cell line. This cell line is indeed easy to handle, has an excellent transfectability, a high capacity for recombinant expression and tolerates well media low in serum (thus allowing to minimize the source of protein contamination) or media supplemented with selenomethionine (Aricescu et al., 2006).

In a particularly preferred embodiment of the invention, said vector of step i) is the pHLsec vector, and said host cell of step ii) is a HEK293T cell line.

In the further step iii) as described above, the trimer of procollagen III C- propeptide can be obtained by culturing the host cell as defined above in a suitable culture medium under conditions permitting the expression of said trimer, and by recovering said trimer from the host cell if the CPIII monomer is expressed intracellularly, and/or from the culture medium in which the host cell is cultured if the CPIII monomer is expressed extracellularly. According to a particular embodiment, said culture medium may contain selenomethionine. Such medium allows the incorporation of selenomethionine(s) in place of methionine(s) in each CPIII monomer, in order to further generate selenomethyonylated crystal(s) such as crystal c) as described above.

In the further step iv) as described above, the CPIII trimer obtained in step iii) is purified, in order to allow the obtention of a 100%-purified (i.e. free of any contaminant) or almost 100%-purified protein solution. By almost 100%-purified, it is meant herein at least 90 to 99%-purified, preferably 95 to 99%-purified, more preferably 96%, 97%, 98%-purified, and even more preferably 99%-purified. The skilled person in the art may use any conventional method allowing the purification of said CPIII trimer or complex thereof, such as chromatography. Methods for purifying recombinant proteins are described in several well known references such as Burgess et al. (2009).

According to another preferred embodiment, the protein solution provided in step a) as described above contains the procollagen III C-propeptide trimer in a concentration of about 0.5 mg/ml to about 50 mg/ml, preferably of about 10 mg/ml to about 45 mg/ml, more preferably of about 20 mg/ml to about 40 mg/ml, and even more preferably of about 30 mg/ml. Most preferably, said concentration is of 30 mg/ml. As used herein, as well as in further embodiments and aspects of the invention, by the term "about", it is meant to include ±5 % of the value(s) indicated. According to another preferred embodiment of the above method, for subjecting said protein solution to conditions which promote optimal crystallization, step b) comprises the step of growing by sitting or hanging drop technique a crystal comprising or consisting of said CPU I trimer, wherein the crystallization buffer consists of:

a) about 20% PEG 3350, and about 0.1 M Bis-Tris propane pH 6.5, and about 0.2M KN0₃ (crystal a); or

b) about 5% to 10 % PEG 6000, and a mixture of about 0.1 M of Hepes and MES monohydrate pH 6 to pH 7 (crystal b); or

c) about 20% PEG 3350 and about 0.2 M NaCI (crystal c).

More preferably, said crystallization buffer consists of:

a) 20% PEG 3350, and 0.1 M Bis-Tris propane pH 6.5, and 0.2M KN0₃ (crystal a)_; or

b) 5% PEG 6000 and 0.1 M Hepes pH 6.6 ; or 10 % PEG 6000 and 0.1 M MES monohydrate pH 6 ; or 8% PEG 6000 and 60 mM Hepes pH 7 and 40 mM MES pH 6 (crystal b); or

c) 20% PEG 3350 and 0.2 M NaCI (crystal c).

Even more preferably, said crystallization buffer consists of:

a) 20% PEG 3350, and 0.1 M Bis-Tris propane pH 6.5, and 0.2M KN0₃ (crystal a)_; or

b) 5% PEG 6000 and 0.1 M Hepes pH 6.6 (crystal b); or

c) 20% PEG 3350 and 0.2 M NaCI (crystal c).

According to another preferred embodiment, in step b) as described above, the crystallization temperature is of 5°C to 30°C, more preferably of 10° to 25°C, even more preferably of 21 °C.

In yet another preferred embodiment, in step b) as described above, conditions to promote optimal crystallization of the procollagen III C-propeptide trimer are as set forth in Table 1 (M).

In a further aspect, the present invention provides a method for determining the three-dimensional structure of the crystal of the present invention, said method comprising the steps of:

a) providing at least one crystal comprising or consisting of a procollagen III C- propeptide trimer, said crystal being preferably obtained according to the method for producing a crystal as described above ; b) flash-cooling said crystal into liquid nitrogen after a brief transfer to a cryo- protecting buffer ; and

c) analyzing said crystal to determine its three-dimensional structure.

Said method can thus allow the obtention of the atomic coordinates which define the three-dimensional structure of the crystal according to the invention.

According to a preferred embodiment, said cryo-protection buffer of step b) comprises or consists of perfluoropolyether oil (crystal a); or about 25% ethylene glycol (crystal b); or about 30% (v/v) of glycerol (crystal c).

According to another preferred embodiment, the analysis of step c) is carried out by X-ray diffraction. Data sets generated from the diffraction analysis can be analyzed by using any appropriate well known software, including, without limitation, Xia2, XDS, MOSFLM and SCALA from the CCP4 program suite (http://www.ccp4.ac.uk), AutoSol from Phenix (http://www.phenix-online.org), MOLREP, REFMAC, TLS, MolProbity, DAL I and combinations thereof.

According to yet another preferred embodiment, the analysis of step c) is carried out as follows:

i) the structure of crystal c) as defined above is solved by single anomalous dispersion (SAD) ; and/or

ii) the structure of crystal a) as defined above is solved by molecular replacement, preferably using a monomer from crystal c) as search model; and/or

iii) the structure of crystal b) as defined above is solved by molecular replacement, preferably using a monomer from crystal a) or from crystal c) as search model.

By analyzing the three-dimensional structure of the crystal according to the invention, one skilled in the art can determine critical sites involved in procollagen assembly and in procollagen propeptide cleavage (and consequently fibril assembly), and thus identify compounds capable of modulating said processes. Said compounds may then be useful for therapeutic strategies, wherein it might be desired to increase or decrease the amount of collagen. Indeed, until the elucidation of the three- dimensional structure of the crystal according to the invention, no information was available for structure-based development of therapeutic compounds based on the structure of a procollagen C-propeptide trimer. So, in a further aspect, the invention relates to a method for identifying a compound modulating the trimerization of procollagen III C-propeptide, comprising the steps of:

a) providing the atomic coordinates of Table A, Table B or Table C, or a combination thereof, thereby defining a three-dimensional structure of the procollagen III C-propeptide trimer ;

b) using said three-dimensional structure to design or select a compound modulating the trimerization of procollagen III C-propeptide by computer modeling;

c) providing said compound.

As used herein, the terms "modulating the trimerization of procollagen III C- propeptide" mean to inhibit or activate the formation of a procollagen III C-propeptide trimer in a sufficient manner such that the assembly of procollagen III is prevented or stimulated, respectively.

In a preferred embodiment, it is useful to identify, by the method described above, compounds inhibiting the trimerization of procollagen III C-propeptide. Said compounds may indeed be used to treat or prevent disorders associated with angiogenesis, and/or pathologies associated with an excessive amount of collagen such as fibrotic disorders (e.g. liver fibrosis, cardiac fibrosis, pulmonary fibrosis, etc) or scarring disorders (e.g. keloid disease, hypertrophic scarring, corneal scarring, etc).

In another preferred embodiment, it is useful to identify, by the method described above, compounds activating the trimerization of procollagen III C- propeptide. Said compounds may indeed be used to promote wound healing in a subject in need thereof.

Examples of modulating compounds as described above include, but are not limited to, peptides, antibodies and small molecules, that would be expected to interfere with the trimerization of procollagen III C-propeptide.

According to a further preferred embodiment, said compound modulating the trimerization of procollagen III C-propeptide binds to at least one of the amino acid residue selected from the group of amino acid residues at position 120, 121 , 122, 123, 124, 125, 126, 127, 128, 129, 130, 131 , 140, 141 and 142 of sequence SEQ ID N°1 , and of amino acid residues at position 131 , 132, 133, 134, 135, 136, 137, 138, 139, 140, 141 , 142, 151 , 152 and 153 of sequence SEQ ID N°2 or SEQ ID N°6. Even more preferably, the compounds binding said amino acids inhibit the trimerization of procollagen III C-propeptide. In yet another preferred embodiment, the method for identifying a compound modulating the trimerization of procollagen III C-propeptide further comprises the step: d) physically contacting said compound with procollagen III C-propeptide to determine the ability of said compound to modulate the trimerization of procollagen III C-propeptide.

It is another aspect of the invention is to provide a method for identifying a compound modulating the binding of Procollagen C-proteinase Enhancer 1 (PCPE1 ) to the procollagen III C-propeptide trimer, comprising the steps of:

a) providing the atomic coordinates of a crystal comprising or consisting of the complex procollagen III C-propeptide trimer / CUB1 CUB2 domains of Procollagen C-proteinase Enhancer 1 as described above, thereby defining a three-dimensional structure of said complex;

b) using said three-dimensional structure to design or select a compound modulating the binding of the CUB1 CUB2 domains of Procollagen C- proteinase Enhancer 1 to the procollagen III C-propeptide trimer by computer modeling;

c) providing said compound.

As used herein, the terms "modulating the binding of Procollagen C-proteinase Enhancer 1 (PCPE1 ) to the procollagen III C-propeptide trimer" mean to inhibit or activate the binding of Procollagen C-proteinase Enhancer 1 (PCPE1 ) to the procollagen III C-propeptide trimer in a sufficient manner to such that the cleavage of procollagen III propeptide is reduced or stimulated, respectively.

In a preferred embodiment, it is useful to identify, by the method described above, compounds inhibiting the binding of PCPE1 to the procollagen III C-propeptide trimer. Said compounds may indeed be used to treat or prevent disorders associated with angiogenesis, and/or pathologies associated with an excessive amount of collagen such as fibrotic disorders (e.g. liver fibrosis, cardiac fibrosis, pulmonary fibrosis, etc).

In another preferred embodiment, it is useful to identify, by the method described above, compounds activating the binding of PCPE1 to the procollagen III C- propeptide trimer. Said compounds may indeed be used to promote wound healing in a subject in need thereof.

Examples of modulating compounds as described above include, but are not limited to, peptides, antibodies and small molecules, that would be expected to interfere with the binding of PCPE1 to the procollagen III C-propeptide trimer. In another preferred embodiment, said compound modulating the binding of PCPE1 to the CPIII trimer binds to at least one lysine residue of the procollagen III C- propeptide selected from the group of lysine residues at position 18, 35, 45 and 52 of sequence SEQ ID N°1 , and lysine residues at position 29, 46, 56 and 63 of sequence SEQ I D N°2 or SEQ I D N°6. More preferably, said compound binds to at least one lysine residue of the procollagen I I I C-propeptide selected from the group of lysine residues at position 1 8 and 35 of sequence SEQ ID N°1 , and lysine residues at position 29 and 46 of sequence SEQ ID N°2 or SEQ ID N°6.

In yet another preferred embodiment, said compound binds to at least one of the amino acid residue of the CUB1 CUB2 domains of PCPE-1 selected from the group of amino acid residues at position 68, 90, 109, 191 and 233 of sequence SEQ ID N°3 or SEQ I D N°4. More preferably, said compound binds to at least one of the amino acid residue of the CUB1 CUB2 domains of PCPE-1 selected from the group of amino acid residues at position 191 and 233 of sequence SEQ ID N°3 or SEQ ID N°4.

Even more preferably, the compounds binding said amino acids inhibit the binding of PCPE-1 to procollagen III C-propeptide.

I n another preferred embodiment, the method for identifying a compound modulating the binding of Procollagen C-proteinase Enhancer 1 (PCPE 1 ) to the procollagen III C-propeptide trimer as described above further comprises the step: d) physically contacting said compound with a procollagen I I I C-propeptide trimer and Procollagen C-proteinase Enhancer 1 to determine the ability of said com pou n d to mod u late the bi nd i ng of Procol lagen C-proteinase Enhancer 1 (PCPE1 ) to the procollagen III C-propeptide trimer. In the method(s) described above for identifying compound(s) modulating the trimerization of procollagen I II C-propeptide or modulating the binding of PCPE1 to the CPIII trimer, said compound(s) may be designed de novo, using the three-dimensional structure of the crystal according to the invention alone or in combination with a portion of a known compound.

For de novo design , one skilled in the art may use any suitable computer modeling program well known in the art. Design in these modeling programs is generally based upon the prediction of a conformational interaction between the three- dimensional structure of a protein (e.g. of the crystal of the present invention) and a candidate compound. For example, generally, for a protein to effectively interact with a compound, it is necessary that the three-dimensional structure of the compound assumes a compatible conformation that allows the compound to bind to the protein in such a manner that a desired result is obtained upon binding. The knowledge of the three-dimensional structure of the protein thus enables a skilled artisan to design or select a compound having such compatible conformation. Examples of such program include, but are not limited to, LUDI (Bohm et al., 1992), LeapFrog (Tripos), CAVEAT (Bartlett et al., 1984), GRID (Goodford et al., 1985), MCSS and HOOK (Miranker et al., 1991 ; Eisen et al., 1994), BREED (Pierce et al., 2004) and combinations thereof. Other computer modeling techniques known in the art may also be used (Schneider et al., 2008; Holtje et al., 2008; Schneider et al., 2005).

For de novo design, one skilled in the art may also generate candidate compounds by screening random peptide libraries produced for example in recombinant bacteriophage (Scott et al., 1990; Cwirla et al., 1990), or a combinatorial chemical library. Candidate compounds selected in this manner can be systematically modified by computer modeling programs until one or more promising candidate compounds are identified.

In the method(s) described above for identifying compound(s) modulating the trimerization of procollagen III C-propeptide or modulating the binding of PCPE1 to the CPIII trimer, said compound(s) may also be selected from a known compound. For example, one skilled in the art may select a candidate compound by electronic screening of well-known large compound libraries, such as the Available Chemical Directory (ACD; http://www.orqanicworldwide.net/content/available-chemical-directory). Compounds of such libraries may be analyzed by docking programs, which include, without limitation, the programs DOCK (Kuntz et al., 1982) and AUTODOCK (Goodsell et al., 1990).

Once candidate compounds are identified, they can be chemically synthetized, and their biological activity tested as follows.

For example, the capacity of a compound to modulate the trimerization of procollagen III C-propeptide may be assessed according to a method easily adapted from that described by Lees et al. (1997), wherein the CPIII trimer will be incubated in the absence or presence of the candidate compound at a desired concentration(s). Similarly, the capacity of a compound to modulate the binding of PCPE1 to the CPIII trimer may be assessed according to a method easily adapted from that described by Vadon-Le Goff (201 1 ), wherein the PCPE-1 / CPIII trimer complex will be incubated in the absence or presence of the candidate compound at a desired concentration(s). It is another aspect of the invention to provide a method for solving the three- dimensional structure of a different procollagen C-propeptide trimer or complex thereof, by homology modeling using the three-dimensional structure of the crystal according to the present invention. For example, such a method may be carried out to solve the 3D structure of a different CP trimer of which the amino acid sequence is known (e.g. publicly available on an online database, such as the ncbi databases).

Advantageously, said method comprises the step of:

a) providing the atomic coordinates of Table A, Table B or Table C or a combination thereof, thereby defining a three-dimensional structure of the procollagen III C-propeptide trimer ;

b) providing the amino acid sequence of a different procollagen C-propeptide trimer; and

c) performing homology modeling so as to solve the three-dimensional structure of the procollagen C-propeptide trimer of step b).

The present invention will be better understood in the light of the following detailed description of experiments, including examples. Nevertheless, the skilled artisan will appreciate that this detailed description is not limitative and that various modifications, substitutions, omissions, and changes may be made without departing from the scope of the invention. BRIEF DESCRIPTION OF THE DRAWINGS

Figure 1. (A) Amino acid sequence of the expressed protein. The arrow indicates the start of the secreted protein, after cleavage of the signal peptide. The His₆ sequence is shown at amino acid positions 32 to 37 and the arrowhead shows the start of the corresponding native protein, after cleavage from procollagen by BMP-1 and tolloid-like proteinases. The Asn185Q mutation in the N-glycosylation site is boxed. (B) Amino- acid sequence of the CPIIIHis monomer expressed in mammalian cells (SEQ ID N°2) or insect cells (SEQ ID N°6), and of the CPIII monomer without a tag (SEQ ID N°1 ). Figure 2. SDS-PAGE analysis. 5 μg of purified CPIIIHis trimer was analyzed on a 10 % acrylamide gel, in non-reducing conditions, followed by Coomassie Blue staining. Figure 3. Mass spectrometry analysis. (A) MALDI-TOF spectrum of non-reduced CPIIIHis trimer showing the major, singly charged [M+H]+ ion at m/z = 86403, as expected for the trimer, as well as doubly [M+2H]2+ and triply [M+3H]3+ charged ions at m/z = 43145 and 28763, respectively. (B) MALDI-TOF spectrum of reduced CPIIIHis trimer showing a major peak at m/z 28769, as expected for the monomer form. The minor [M+H]+ ion at m/z = 28985 probably corresponds to a non-covalent adduct with one molecule of sinapinic acid matrix. (C) MALDI-TOF spectrum of the CPIIIHis trimer Se-Met derivative showing a major [M+H]+ ion at m/z = 29023, corresponding to the incorporation of approximately five Se-Met residues per monomer. The minor [M+H]+ ion at m/z = 28773 corresponds to unlabeled CPIIIHis trimer.

Figure 4. Circular dichroism. Spectra of CPIIIHis trimer at 25 °C in 20 mM Tris pH 7.4 in the presence or absence of 2.5 mM CaCI₂.

Figure 5. Crystallization. Crystals of (left) the Se-Met derivative (form I) are shown as well as the two native forms (centre) II and (right) III of CPIIIHis trimer. Scale bars = 200 m.

Figure 6. Sequence alignment of the C-propeptides of the major human fibrillar procollagen chains. Identical residues are shown in white on a black background, with similar residues shown black on white in boxes. Different structural regions and secondary structure elements are indicated, as well as Cys residues (identified as Cys 1 to 8) and pairs of intra-chain disulphide bonds are shown [Cys1-Cys4 (positions 41 and 73); Cys5-Cys8 (positions 81 and 243); and Cys6-Cys7 (positions 151 and 196)], as well as pair of inter-chain disulphide bonds [Cys2-Cys3 (positions 47 and 64)]. The single N-linked glycosylation site is indicated by ^* (note that Asn146 was mutated to Gin in the structure presented here), residues involved in Ca²⁺ coordination by · and the long and short stretches of the discontinuous 15 residue chain recognition sequence are shown at amino acid positions 120 to 131 and 140 to 142 respectively. Numbering refers to the C-propeptides of the proal (I II) chain. Sequence alignments and rendering were done using CLUSTALW (Thomson et al., 1994) and ESPript (Gouet et al., 1999), respectively.

Figure 7. Three-dimensional structure and interactions within the C-propeptide trimer of human procollagen III. (A) Identification of secondary structure elements in chain B of the trimer. (B) Structure at 3.5A resolution showing the stalk, base and petal regions. (C) Structure shown in (B) at 3.5A resolution rotated by 90° and viewed from the top showing the three petals, the triangle of helices 4 and the interaction interface (arrowheads) involving the long and short stretches of the chain recognition sequence. Note that residues 1 -13 of the C-propeptide were not visible on the structure.

Figure 8. Details of the interaction interface. (A) Close-up of the A/B chain interface (1 .7A structure) showing the inter-chain interactions. (B) Cut-away view (as in Fig. 7b with one chain removed) showing, in surface representation, charge complementarity at the inter-subunit interface (negatively charged, grey; positively charged, black). Residues involved in inter-chain interactions are indicated. (C) Same view as in (B) but correlated with the extent of sequence conservation seen in Fig. 6 (light grey, no homology; white, weak homology; dark grey, strong homology/identity). Drawn using PyMOL, Version 1 .4.1 , Schrodinger, LLC.

Figure 9. Structural alignment of the three chains of the proal (I II) C-propeptide trimer in the (A) 2.2A and (B) 1.7A structures (space groups P212121 ). While overall alignment is good, the conformation of chain C differs from those of chains A and B particularly on the C-terminal side of helix 4, at Leu 139 (arrow), immediately before the short stretch of the chain recognition sequence (CRS; amino acid residues 140 to 142). Drawn using PyMOL, Version 1.4.1 , Schrodinger, LLC. (B) Comparison of residues involved in inter-chain interactions in the chain recognition sequences of procollagens I, II and III. Negatively charged residues are represented by -, and positively charged by +.

Figure 10. Positions of known missense mutations in the C-propeptides of fibrillar procollagen types I, II, III and V, mapped on to the C-propeptide of proal (III). One chain of the proal (III) C-propeptide trimer is shown on the left side, with the other chains shown (in part) in the right corner. Only mutation sites where the corresponding residues in the proal (111) chains are identical are shown. Sites associated with lethal/severe forms of 01 or PLSD-T/SPD are shown in positions 44, 59, 94, 137, 148, 149, 168, 169, 194, 197, 206, 218, 227, 243 and 245, while mild/moderate forms are shown in positions 38, 56, 63, 81 , 104, 175 and 229. Two different mutations of Asp222 in the proal (I) chain can lead either to mild or lethal 01. Mutations sites that are specific to proal (III) are shown in positions 37, 52 and 92, while one mutation specific to proal (V) is shown in position 41 . Sites are numbered from the start of the C-propeptide domain. Drawn using PyMOL, Version 1 .4.1 , Schrodinger, LLC. See also Fig. 20.

Figure 11. Role of the C-propeptides (C-pro) in both intracellular assembly of the procollagen molecule and also extracellular assembly of the collagen fibril. Adapted from Myllyharju and Kivirikko (2004), with permission.

Figure 12. Stereo view of chain A from the 3.5 A structure (form III) in the corresponding 2Fo-Fc electron density map contoured at 1 .5σ. Drawn using PyMOL, Version 1 .4.1 , Schrodinger, LLC.

Figure 13. Close-up (stereo view) of the Ca²⁺ binding site (1 .7A structure, form II) in the corresponding 2Fo-Fc electron density map contoured at 1.5 σ. Ca²⁺ octahedral coordination involves Asp59, Asn61 , Gln62, Cys64 and Asp67 in one chain as well as a water molecule hydrogen bonded to Asp43 in a neighboring chain. Also shown is the inter-chain disulfide bond involving Cys47 and Cys64. Interactions involving Gln132 (not shown) from helix 4 also stabilize the Ca²⁺ binding loop. Drawn using PyMOL, Version 1 .4.1 , Schrodinger, LLC.

Figure 14. Stereo view of the entire 1.7A structure (form II; backbone trace) showing the three different chains along with bound Ca²⁺ ions shown as spheres. Drawn using PyMOL, Version 1 .4.1 , Schrodinger, LLC. Stereo view of the entire 1 .7A structure (form II; backbone trace) showing the three different chains along with bound Ca²⁺ ions. Drawn using PyMOL, Version 1.4.1 , Schrodinger, LLC.

Figure 15. Close-up of the Ca²⁺ binding loop site and the inter chain disulphide bond (form III, 3.5A) within the corresponding 2Fo-Fc electron density map contoured at 1 .5 σ. Drawn using PyMOL, Version 1 .4.1 , Schrodinger, LLC.

Figure 16. Side (left) and top (right) views of a cartoon representation of the base region (residues 30-76; Fig.6) of the human procollagen III C-propeptide trimer (form II, 1 .7 A structure). Bound Ca²⁺ ions are shown as spheres, along with the intra-chain and inter-chain disulphide bonds. Secondary structures are also indicated. Drawn using PyMOL, Version 1 .4.1 , Schrodinger, LLC.

Figure 17. Residues involved in stabilizing the interface between adjacent chains in the procollagen III C-propeptide trimer (excluding the stalk region). The inter-chain disulphide bond is indicated by the thick line, salt bridges by thin lines and hydrogen bonds by dotted lines. The remainder are interfacing residues. Corresponding secondary structure elements are also indicated. Residues in the chain recognition sequence are highlighted in grey (long stretch, residues Leu124 to Val131 ; and short stretch, residues Ser140 to Arg142). Interactions calculated using the PDBePISA (Krissinel et al., 2007) server at the European Bioinformatics Institute (http://www.ebi.ac.uk/pdbe/prot_int/pistart.html).

Figure 18. Comparison between different types of globular region involved in fibrous protein trimerization. (A) fibrillar procollagen C-propeptides (procollagen III; buried surface area ~ 3800 A²), (B) fibrinogen domains (L-ficolin; Garlatti et al., 2007; PDB code 2J3G; buried surface area ~ 2900 A²) (C) C1 q family, Gaboriaud et al., 2003 (collagen X NC1 trimer; Bogin et al., 2002; PDB code 1 GR3; buried surface area ~ 5600 A²) (D) collagen IV NC1 region, Than et al., 2002 and Sundaramoorthy et al., 2002 (PDB code 1 LI 1 ; buried surface area ~ 13400 A²) (E) collectins, Sheriff et al., 1994, and Weis et al.,1994 (mannan binding lectin; PDB code P30B; buried surface area ~ 900 A²). In all cases, views are from the C-terminal end of the molecule looking down the principal axis, with only the globular regions shown (i.e. omitting underlying collagen-like or a-helical coiled-coil regions). Bound Ca²⁺ ions are shown as spheres. Among these structures, only the procollagen C-propeptide trimer is stabilised by inter- chain disulphide bonds. Buried surface areas calculated using the PDBePISA server at the European Bioinformatics Institute (http://www.ebi.ac.uk/pdbe/prot_int/pistart.html). Drawn using PyMOL, Version 1 .4.1 , Schrodinger, LLC.

Figure 19. Structural similarity with angiopoietin-3. (A) Structural alignment of chain A of the proal (I II) C-propeptide trimer (1.7A structure; the Ca²⁺ ion can be seen as a sphere at the bottom) with the receptor binding domain of angiopoietin-2 (Barton et al., 2005; PDB code 1 Z3S; the Ca²⁺ ion can be seen at the top as a sphere), obtained using DALI. Note that the equivalent of helix 4 in the C-propeptide structure is interrupted by a large loop (arrowhead) in angiopoietin-2. Structural similarity in the base region includes a conserved intra-chain disulphide bond. Drawn using PyMOL, Version 1.4.1 , Schrodinger, LLC. (B) Sequence alignment of the C-propeptide of human procollagen III (CPIII) with the receptor binding region of angiopoietin-2 (ANG- 2). Sequence identity is less than 15 %. Sequence alignment and rendering done using CLUSTALW and ESPript, respectively.

Figure 20. Alignment of the proal (I), proa2(l), proa1 (ll), proal (III) and proa1 (V) C- propeptides showing the locations of all known naturally occurring missense mutations (see Table 4). Different regions and secondary structure elements found in the procollagen III C-propeptide are also indicated, as are predicted secondary structures (obtained using PsiPred; Buchan et al., 2010) for the other C-propeptides. Also shown are the positions of Cys residues (numbered according to the sequence and also as Cys 1 to 8) with intra-chain disulphide bonds identified as in Figure 6. The single relinked glycosylation site is indicated by ^* (note that N146 was mutated to Gin in the structure presented here), the residues involved in Ca²⁺ coordination by · and the long and short stretches of the discontinuous 15 residue chain recognition sequence are shown at amino acids positions 120 to 131 and 140 to 142, respectively. Numbering refers to the C-propeptides of the proal (111) chain. Sequence alignments and rendering were done using CLUSTALW and ESPript, respectively.

Figure 21. Alignment plot of the C-propeptides of the native and chimeric proa-chains from type I and I II procollagens (adapted from Lees et al.; 1997).

Figure 22. BMP-1/tolloid-like proteinases in matrix assembly.

Figure 23. BMP-1/tolloid-like proteinases.

Figure 24. Low resolution structure of the CUB1 CUB2 : CPIII complex (X-ray scattering). (A) Lower part: X-ray scattering profiles for CPIII-Long, CPIII-His and CUB1 CUB2 (dots) together with fits generated by DAMMIF (solid lines). Corresponding low resolution structures are shown for each curve, represented as dummy atom bead models. Upper part: averaged low resolution structures for each molecule calculated using DAMAVER. Diagrammatic representations of CPIII-His and CPIII-Long are also shown. His = N-terminal his-tag; C-telo = C-terminal telopeptide; CPIII = C-propeptide trimer of procollagen III. All proteins were expressed in a baculovirus system. (B) Lower part: observed scattering profiles for the CUB1 CUB2:CPIII-His and CUB1 CUB2:CPIII-Long complexes (dots) together with fits generated by MONSA (solid lines). Upper part: Corresponding low resolution structures generated by MONSA, showing CUB1-CUB2-Bac in black and CPIII-His/CPIII-Long in gray. Note the resolution of the CPIII models in (B) is less than in (A), due to the limited resolution of the CUB1 CUB2 data. Also, to improve clarity, scattering curves have been shifted arbitrarily in the vertical direction (logarithmic scale). Molecules and complexes are represented using the programs PyMol and Situs.

Figure 25. Localization of interacting residues in the CUB1 CUB2 region of PCPE-1 . (A) Cartoon representations of 3D structural models of the CUB1 and CUB2 domains, showing putative Ca²⁺ binding sites (Ca²⁺ ions shown as spheres), residues shown previously to be required for CPIII binding (Blanc et al., 2007) as well as putative Ca²⁺ coordinating residues in CUB2, all shown in dark grey. (B) Percent conversion of a CPIII-Long substrate (350 nM) by BMP-1 (16 nM) in the absence and presence full- length PCPE, its CUB1 CUB2 fragment and CUB1 CUB2 containing the D191A mutation in the CUB2 domain (all at 350 nM). All proteins expressed in 293T cells. Incubation for 1 hr at 37 °C. WT = wild-type. Analysis by SDS-PAGE (4-20 % gradient gels; reducing conditions) and Sypro Ruby staining, then quantitation by laser scanning densitometry. (C) Surface plasmon resonance (Biacore) analysis of the binding of CUB1 CUB2 (WT or its D191A mutant; 0-256 nM) to immobilized (595 response units) CPIII-Long.

Figure 26. Localization of interacting residues in CPIII. (A) Analysis of PCPE-1 enhancing activity. CPIII-Long (340 nM; both wild-type (WT) and the K18A, K35Q and K45Q mutants) was incubated either alone, with BMP-1 alone (16 nM) or with BMP-1 (16 nM) and PCPE-1 (340 nM) for 1 hr at 37 °C. Analysis by SDS-PAGE (4-20% gradient gels; reducing conditions) and Sypro Ruby staining. (B) Surface plasmon resonance (Biacore) analysis of the binding of CPIII-Long (0-256 nM for both wild-type (WT) and the K45Q mutant; 0-1 μΜ for the K18A and K35Q mutants) to immobilized (74 response units) PCPE-1.

Figure 27. Positions of lysines in CPIII and a model of the CUB1 CUB2:CPIII complex. (A) Positions of conserved lysine residues (shown by black spheres located at the C- alpha atoms) in the 3D structure of CPIII-His. (B) Cartoon sketch of the CUB1 CUB2:CPIII complex showing the CUB1 CUB2 fragment of PCPE-1 bound to the stalk up to the base region of CPIII. Binding involves interactions between exposed lysine residues K18 and K35 on CPIII (represented by +) to acidic residues involved in Ca²⁺ coordination in CUB1 CUB2 (represented by -).

Figure 28. Kinetics of PCPE enhancement of the cleavage of CPIII-Long by BMP-1 . Substrate (CPIII-Long; 0-3000 nM) was incubated with BMP-1 in the absence and presence of PCPE-1 . When present, PCPE-1 was used at equimolar concentrations with respect to substrate. In all cases, incubation conditions were adjusted to remain within the linear region of the plot of amount of product released as a function of time. Analysis by SDS (PAGE (4-20% gradient gels; reducing conditions), then Sypro Ruby staining and quantitation by laser scanning densitometry.

Figure 29. (A) Gel filtration chromatography of isolated PCPE-1 and CPIII as well as a mixture of both proteins (containing an excess of PCPE-1 ). The PCPE-1 :CPIII complex is larger than CPIII and could be separated from excess free PCPE-1 . The vertical scale is arbitrary as several elution profiles are superimposed. (B) Absence of change in secondary structure on mixing CPIII-Long-Bac and CUB1 CUB2-Bac. Circular dichroism spectra were first recorded separately for CPIII-Long-Bac and CUB1 CUB2- Bac, at 25 °C in 20 mM Tris pH 7.4, 0.15 M NaF and 1 mM CaCI₂, then mean residue weight molar ellipticity was calculated for the mixture and compared with that measured for a 1 :1 molar ratio.

Figure 30. Distance distribution functions p(r) calculated from the SAXS data showing the distribution of intra-particle distances and maximum dimensions D_max (indicated by the right hand intercept with the horizontal axis) for (A) CUB1 CUB2, (D) CPIII-His, (C) CPIII-Long,(D) CUB1 CUB2:CPIII-His complex and (E) CUB1 CUB2:CPIII-Long complex.

Figure 31. Gallery of solutions determined by DAMMIF for the low resolution structures of (A) CUB1 CUB2 (B) CPIII-His and (C) CPIII-Long.

Figure 32. Gallery of solutions determined by MONSA for the low resolution structures of the (A) CUB1 CUB2:CPIII-His and (B) CUB1 CUB2:CPIII-Long complexes. Each molecule is represented as a collection of "dummy atoms", with CUB1 CUB2 shown in black and CPIII-His and CPIII-Long shown in gray. Note that CUB1 CUB2-Bac and CPIII-His are found to be aligned at the base of the stalk region while CPIII-Long projects beyond the CUBCUB2 binding site at the base of the stalk region.

Figure 33. Amino acid sequence alignment in the stalk/base regions of selected fibrillar procollagen C-propeptides (types I, II, III and V), showing highly conserved regions as white on black, obtained using MUSCLE alignment software. Secondary structures for the known structure of the C-propeptide of human procollagen III are shown at the top. Locations of the highly conserved lysine residues at positions 18, 35 and 45 are indicated. Note that these positions are not occupied by lysines in the proa1 (V) chain of procollagen V.

Figure 34. Possible mechanism of action of PCPE-1.

EXAMPLES

EXAMPLE 1 : Large scale production and crystallization of the C-propeptide trimer from human procollagen III for crystal structure determination

The first crystallization of a C-propeptide domain, from human procollagen III, is described. Following transient expression in mammalian 293T cells of both the native protein and a selenomethionine derivative, two crystal forms of the homotrimer were obtained, one orthorhombic (P212121 ) diffracting up to 1 .7 A and one trigonal (P321 ) diffracting up to 3.5A. Characterization by MALDI-TOF mass spectrometry allowed the efficiency of selenomethionine incorporation to be determined.

/. MA TERIALS AND METHODS

Details of protein expression, purification, crystallisation and data collection are fully described below. Briefly, the construct CPU I His, consisting of the C-propeptide trimer from human procollagen III (each chain mutated at the single N-linked glycosylation site) together with an N-terminal His₆-tag, as well as its Se-Met derivative, were expressed by transient transfection of HEK 293 T cells. Following crystallisation, X-ray diffraction data were collected at 100 K, at 0.9795 A (form I, SeMet, peak data collected only) or 0.9763 A (forms II and III), on beamlines I03 and I04 at Diamond Light Source, Didcot, UK. Data were processed using XDS36, as well as Xia2, XDS, MOSFLM and SCALA from the CCP4 programme suite (http://www.ccp4.ac.uk). Three different crystal forms were obtained (Table 3). First, the structure of the Se-Met derivative (form I, resolution 2.2A) was solved by the single anomalous dispersion method using the programme AutoSol from Phenix (http://www.phenix-online.org). Next, the structure corresponding to form II (native protein, 1 .7A resolution) was solved by molecular replacement using MOLREP with a monomer from form I as search model. Finally, a monomer from the 1.7A structure served as a guide for structure determination by molecular replacement of form III (native protein, resolution 3.5A). All structures were refined over several rounds using REFMAC (including TLS for form III), alternating with manual adjustments in Coot. Geometry was checked with using MolProbity. Ramachandran statistics were as follows: form I (favored region 96.5 %, allowed 3.5 %, disallowed 0 %), form II (favored region 97.1 %, allowed 2.9 %, disallowed 0 %), form III (favored region 98.2 %, allowed 1 .8 %, disallowed 0 %). Structure similarity searches were carried out using DALI.

1.1. Expression and purification

DNA encoding the C-propeptide trimer from human procollagen III (CPU I His trimer), was amplified from a previous construct (CPU I QQ pBAC3) (Vadon-Le Goff et al., 201 1 ) using the following primers:

forward 5' - ACCGGTCATCATCACCACCATCACTCC- 3' (SEQ ID N°7), and reverse 5' - TCTAG ACTCG AGTTATAAAAAG CAAACAG G- 3' (SEQ ID N°8); and then inserted into the Age I and Xho I sites of the pHLsec vector (Aricescu et al., 2006), for expression in HEK293T mammalian cells. The corresponding protein is mutated at the single N-linked glycosylation site (N185Q) and carries an N-terminal His₆ tag followed by a Ser-Ala sequence just before the start of the native protein (see Fig. 1 ). Other constructs were made in parallel in order to produce the CPU I His trimer from insect cells (via a baculovirus system), both in a glycosylated form (no N185Q mutation in the C-propeptide) and in a non-glycosylated form (presence of the N185Q mutation in the C-propeptide). For cloning purposes, the His₆ tag in the CPU I His construct used for expression in insect cells was preceded by the sequence AMV, whilst in the form used for expression in HEK293T mammalian cells, this was replaced by the sequence ETG.

Plasmid DNA was amplified in E. coli XL1 blue cells then purified using the Endofree Plasmid Giga kit (Qiagen). For protein expression in mammalian cells, the HEK 293T cells were cultured in six 555 mL Hyperflasks (Corning) in a CompacT SelecTTM automated cell culture system (TAP Biosystems) in DMEM (high glucose) supplemented with 1 X non-essential amino acids (PAA) and 10 % fetal bovine serum (FBS, Invitrogen). The cells were transfected at 90% confluence with DNA-PEI transfection mixture. This latter was prepared, for each Hyperflask, by pre-incubating 1 mg plasmid DNA with 2 mg branched polyethyleneimine (PEI MW 25,000; Aldrich) for 10 min at room temperature in 100 mL serum-free DMEM. After the DNA-PEI mixture was delivered into each Hyperflask, DMEM containing 2% FBS (455 mL) was used to top up the flask (Zhao et al., 201 1 ).

After 4 days, conditioned medium (3.3 liters) was collected, then clarified by centrifugation and filtration through a SteritopTM vacuum driven filtration system (Millipore). The supernatant was then dialyzed over two days (with one change) versus phosphate buffered saline at 4 °C. Dialyzed medium was then applied to a 5 mL column of Talon Co2+ affinity resin (Clontech), followed by washing with four column volumes of phosphate buffer saline (PBS) then two column volumes of PBS containing 20 mM imidazole. Bound protein was then eluted with 250 mM imidazole in 20 mM Tris-HCI pH 8.0, 150 mM NaCI. Fractions were then pooled, microconcentrated (MWCO 30 kDa) and further purified on a Superdex 200 16/60 column, eluted in 20 mM Hepes pH 7.4, 150 mM NaCI. Finally, fractions were analyzed by SDS-PAGE and further concentrated to -30 mg/mL.

For production of the selenomethionine derivative, cell culture and transfection were as above, using twelve roller bottles (Greiner) instead of Hyperflasks. After 24- 48h transfection in normal DMEM containing 2% FCS (250 mL per roller bottle), the culture medium was removed, the cell layer washed twice with PBS then fresh methionine-free DMEM (MP Biomedicals) containing 3% dialyzed FBS medium was added along with L-Gln, non-essential amino acids and 30 mg/mL L-selenomethionine (Se-Met; Eburon Organics). After 4 days in culture, the medium was collected and the Se-Met derivative purified as above.

1.2. Mass spectrometry

Mass spectrometry was performed using a Voyager-DE Pro MALDI-TOF mass spectrometer (AB Sciex) equipped with a nitrogen UV laser (λ = 337 nm, 3ns pulse). The instrument was operated in the positive linear mode (mass accuracy: 0.05%) with an accelerating potential of 20 kV. Typically, mass spectra were obtained by accumulation of 600 laser shots for each analysis and processed using Data Explorer 4.0 software (AB Sciex). For analysis of reduced proteins, 10 μ I of CPU I His trimer and its Se-Met derivative (at ~ 3 mg/mL) were first reduced with 30 μΙ of dithiothreitol (DTT, 10 mM in ammonium bicarbonate buffer) for 45 min at 55°C under constant stirring. After desalting with C4 ZipTips (Millipore), samples were mixed with sinapinic acid (saturated solution in 30% acetonitrile and 0.3% trifluoroacetic acid), deposited on the MALDI target and air-dried before analysis.

1.3. Circular dichroism

Far UV circular dichroism measurements were carried out using thermostated 0.2 mm path length quartz cells in an Applied Photophysics Chirascan instrument, calibrated with aqueous d-10-camphorsulfonic acid. CPU I His trimer (~ 0.3 mg/mL) was analyzed after dialysis against 20 mM Tris-HCI pH 7.4 with or without 2.5 mM CaCI₂ or 10 mM EDTA. Multiple spectra were measured in the wavelength range 190 to 260 nm, with wavelength increment 1 nm, integration time 4 sec and bandpass 1 nm, then averaged before calculation of mean residue ellipticities ([9]MRW). Concentrations were determined from absorbance at 280 nm, measured by Nanodrop, using the extinction coefficient calculated from the amino acid sequence.

1.4. Crystallization and data collection

Initial screening and optimization of crystallization conditions was performed using a Cartesian Technologies pipetting robot with 96-well sitting-drop vapor diffusion plates (Greiner). Crystallization kits used were from Hampton Research (Crystal Screen; Crystal Screen 2; Grid Screen Ammonium sulfate; Grid Screen MPD; Grid Screen PEG 6000; PEG Ion; Index and SaltRx), Molecular Dimensions (PACT premier), Qiagen (JSCG; Ammonium Sulfate; PEGS Suite) and the Oxford Protein Production Facility (Blocks 1-3; http://www.oppf.ox.ac.uk/OPPF). The inventors tested about 800 conditions before identifying the optimal combinations, and concentrations, of salt(s), buffer, pH and/or precipitant(s) allowing the crystallization of the C-propeptide trimer from human procollagen III: the conditions tested are listed in Tables 1A to 1 L below, and optimal conditions for crystallization are summarized in Table 1 M.

For each drop, 100 nl of protein was mixed with 100 nl reservoir solution from a total reservoir volume of 100 μΙ. Images were taken automatically at regular intervals using a TAP Biosystems storage vault (Walter et al., 2006) maintained at 21 °C.

For data collection, crystals were flash-cooled into liquid nitrogen. Form I crystals were cryo-protected by gradually increasing the glycerol concentration of the mother liquor to 30% (v/v), form II crystals were immersed in oil (perfluoropolyether PFO- X125/03, Alfa Aesar) and form III crystals were cryo-protected with 25% ethylene glycol. Diffraction data were collected on beamlines I03 and I04 at the Diamond Light Source synchrotron (Didcot, UK). Data were processed using Xia2, XDS and MOSFLM and scaled with SCALA from the CCP4 program suite (http://www.ccp4.ac.uk). Each data set was collected from a single crystal; crystal data and data collection statistics are given in Table 1 M.

Tables 1(A) to (L). Experimental conditions tested to crystallize CPU I .

TABLE 1 H (non-glycosylated form of CPIMHis mutated at the single N-glycosylation site and expressed in insect cells) :

NO CRYSTALLIZATION OF CPIII

Table 1. (M) Optimal crystallization conditions and data collection statistics for

CPIIIHis.

/. RESULTS

11.1. CPIIIHis

Recombinant C-propeptide trimer from human procollagen III (CPIII His trimer; each chain mutated at the single N-linked glycosylation site and carrying an N-terminal His6 tag) (Vadon-Le Goff et al . , 201 1 ) was expressed by large scale transient transfection in HEK 293T cells (Aricescu et al., 2006). Approximately 18 mg of CPIIIHis trimer were obtained from 3 liters of conditioned medium after expression from mammalian HEK293T cells. Purity was at least 99 % as assessed by SDS-PAGE (Fig. 2 ) , wh i c h s h owed a s i n g l e ba n d ( i n n o n-reducing conditions) migrating at approximately the mass expected for a trimer. The Inventors also checked for purity and trimerization ability by mass spectrometry, in both reducing and non-reducing conditions. By MALDI-TOF, the [M+H]+ ion for trimeric CPI I I His was observed at an m/z value of 86403 +/- 43 (Fig. 3A). After reduction with DTT, the [M+H]+ ion for monomeric CPI II His was observed at m/z = 28769 +/- 14 (Fig. 3B). These figures compared favorably with the expected molecular masses of 86320 Da and 28776 Da, respectively. Thus both the SDS-PAGE and mass spectrometry data show that the presence of the N-terminal His₆ tag did not interfere with trimerization of CPIIIHis.

11.2. Se-Met derivative

For structure determination, as there are no homologues of the fibrillar procollagen C-propeptides in the protein data bank, heavy atom labeling or selenium substitution was required in order to solve the phase problem. Since the transient expression system used here has previously been shown to efficiently i ncorporate free selenomethionine from the culture medium (Aricescu et al., 2006), the Inventors also produced the Se-Met derivative of CPU I His trimer using this system (see above), resulting in good, though somewhat reduced, yields (~ 6 mg).

Analysis of the Se-Met derivative of CPU I His by MALDI-TOF mass spectrometry showed a minor [M+H]+ ion signal at m/z = 28773 +/- 14 as well as a broader, major [M+H]+ ion signal at m/z = 29023 +/- 15 (Fig. 3C). The first peak corresponds to unlabeled monomer (representing ~ 25% of the total) while the broader peak (~ 75 % of the total) indicates a mixed population of selenomethionine-labeled protein species with an average mass corresponding to approximately five selenomethionine residues incorporated into each CPU I His monomer (mass increment per Se-Met residue 47). This compares with six methionine residues per chain observed in the amino acid sequence of CPU I His. Incorporation of the Se-Met label into CPU I His trimer was therefore highly efficient.

11.3. Circular dichroism

There is evidence that the C-propeptides of both procollagens I I and I I I are calcium binding proteins. To investigate the role of calcium in the structure of CPU I His trimer, the Inventors carried out circular dichroism (CD) analysis. Note that Ca²⁺ was not present during the purification of the trimeric CPU I His. In the absence of added Ca²⁺, in 20 mM Tris-HCI pH 7.4, the CD spectrum of said CPU I His shows a broad negative peak with a minimum at 210 nm, characteristic of a protein rich in β-sheets (Fig. 4). The spectrum strongly resembles that of CPU I trimer produced in a baculovirus system. Since it was previously shown that the CD spectrum of baculovirus-produced CPI I I resembled that of the native procollagen I C-propeptide trimer, the Inventors have come to the conclusion that the recombinant trimeric CPI I I produced in HEK 293T cells is representative of the native protein. After overnight dialysis (with one change) against 20 mM Tris-HCI pH 7.4 containing 2.5 mM CaCI₂, the CD spectrum of CPU I His trimer was found to be unchanged (Fig. 4). The Inventors therefore also concluded that binding of Ca²⁺ has either no effect on the secondary structure of CPU I His trimer, or that the protein contains tightly bound Ca²⁺ which remains present throughout the purification process.

11.4. Crystallization and data collection

After concentration to approximately 30 mg/ml, crystallization trials for the unlabeled and Se-Met labeled proteins were set up. After a few days, crystals began to appear in the optimal conditions described in Table 1 M. In general, the crystals were of two types, either needle-like or hexagonal plates (Fig. 5). X-ray diffraction screening of crystals grown in the different conditions resulted in the identification of two crystal forms diffracting X-rays to 1 .7 and 3.5A resolution, in space groups P212121 and P321 , respectively (Table 2). For the Se-Met derivative, screening using the best conditions identified for the unlabeled protein also rapidly resulted in high quality crystals (space group P212121 ) diffracting to 2.2 A resolution and displaying enough anomalous signal for phasing.

Table 2. Data collection and processing.

Values for the outer shell are given in parentheses.

II.4. a) Structure of the procollagen III C-propeptide trimer

Fig. 7 shows the three-dimensional structure of the C-propeptide trimer from human procollagen III. It has the overall shape of a flower, consisting of a stalk, a base and three petals. These structures were determined, by X-ray crystallography, at 3.5A,

2.2A and 1.7A resolution (Table 3).

Table 3. Data collection and refinement statistics.

Values in parentheses are for highest-resolution shell. ^*Four selenomethionine residues were identified in each polypeptide chain. This compares with a total of six methionines in the amino acid sequence, the remaining two being present in the stalk region which was not resolved in forms I and II. These data compare with approximately five selenomethionine residues per chain detected by mass spectrometry.

∑ F_obs(h) - kF_calc(h)

R factor = where k is a scaling factor.

where R free is calculated from a test set constituted by approximately 5% of the number of unique reflections (randomly selected) and k is a scaling factor.

The 3.5A structure (Fig. 7, also Fig. 12) is the most complete, showing the stalk, the base and the petals. The stalk comprises the amino acid sequence up to the first conserved proline residue (Pro30; Fig. 6). It includes an a-helical coiled-coil21 (helix 1 ), corresponding to the relatively highly conserved region from residues 12-27 (Fig. 6). More details (except the stalk) are seen in the 2.2A and 1.7A structures (Fig. 13-16). The base (residues 30-76; Fig. 6) consists of a disulphide bonded ring connecting all three chains (Fig. 16), and includes the first four of the eight cysteines present in each chain. Among the three regions of the molecule, the base is the most highly conserved (60 % sequence identity; Fig. 6). For each chain, this region begins with an almost perfectly conserved 12 residue loop ending in Cys41 , followed by a short a-helix (helix 2) extending up to Cys47. There follows a short loop and a two- stranded anti-parallel β-sheet (strands 1 and 2). The loop connecting strands 1 and 2 (residues 59-68) includes a bound Ca²⁺ ion (Fig. 13), as previously suggested based on sequence analysis (Ricard-Blum et al., 2002). The structure reveals that this ion plays an essential role, stabilizing not only the base region but also the trimer, by coordinating to a water molecule that is, in turn, hydrogen bonded to Asp43 in a neighbouring chain. One of the Ca²⁺ ligands is Cys64, which further stabilizes the trimer by forming the only inter-chain disulphide bond, with an adjacent Cys47. By contrast, Cys41 and Cys73 form an intra-chain disulphide bond, thus settling the long standing debate (Mclaughlin et al.,1998) about the roles of these first four cysteines.

Though the base and the petals together form a single entity in the three- dimensional structure, it is convenient to describe the latter as starting between Cys73 and Cys81 (Fig. 6). On the outer face of each petal (Fig. 7a), there is a twisted anti- parallel beta sheet, comprising seven β-strands (3, 4, 5, 8, 9, 1 1 and 12), which is continuous with that formed by strands 1 and 2 in the base. Notably, strand 12 (at the C-terminus), containing Cys243, inserts between strands 3 and 5 and forms an intra- chain disulphide bond with Cys81 on strand 3. The C-terminal residue (Leu245) is therefore adjacent to the base as well as to residues involved in chain selectivity (see below). On the inner face of each petal (Fig. 7a), there is a short anti-parallel β-sheet (strands 6, 7 and 10), as well as a short a-helix (helix 3), and the inner and outer faces are connected by an intra-chain disulphide bond between Cys151 and Cys196. Further down on the inner face, at the junction with the base, is a relatively long a-helix (helix 4). Almost half the interactions involving the petals implicate residues in and around helix 4 (Fig. 17; also see below), with the three helices 4 from the three subunits forming a triangle sitting on the base (Fig. 7c).

Il.4.b) Chain recognition, trimerization and structural similarities

While interactions within the base region stabilize the trimer, procollagen chain selectivity is assured by the petals. In particular, the highly variable, discontinuous 15 residue chain recognition sequence (CRS) straddles helix 4, with the longer stretch (residues 120-131 ) at the N-terminal end and the shorter stretch (residues 140-142) at the C-terminal end (Fig. 6). While the existence of the CRS has been known for some time, the structural basis of chain recognition has until now remained a mystery. The three-dimensional structure presented here reveals immediately how the CRS controls inter-chain interactions, and in particular the need for a discontinuous sequence. As shown in Figs. 7b and 8a, residues in the long stretch of the CRS on one chain interact with residues in the short stretch of the CRS on a neighboring chain, thus revealing an exquisite mechanism of specific chain recognition. Indeed, the structure defines the key specificity-conferring elements within the CRS and also reveals other regions of the molecule involved in chain recognition (Fig. 17). Specifically, inter-chain interactions include salt bridges between Arg142 (CRS short) and Glu126 and Asp130 (both CRS long), between Asp127 (CRS long) and the conserved Arg42 in the base region, as well as between conserved residues (Glu176 with Lys186 and Arg217). Viewed from the side, the interacting surfaces on chains A and B are seen to consist of patches of positive and negative charge, respectively, interacting with patches of opposite charge on chain C (Fig. 8b). These patches consist of both conserved and variable residues, the latter coming mostly from the CRS (Fig. 8c).

Close examination of both the 1.7A and 2.2A structures reveals subtle differences in the conformations of the three polypeptide chains, with one chain differing from the other two, particularly at the C-terminal end of helix 4 (Figure 9 a, b). Specifically, while in general all three chains superimpose well in a structural alignment, chain C bulges out at Leu 139, immediately before the short stretch of the CRS. This observation was totally unexpected. Since all three chains have the same amino acid sequence, it might have been assumed that their structures would be identical. Instead, these observations raise the intriguing possibility that there is an intrinsic asymmetry in the structure that arises when all three chains pack together. Such an asymmetry might account for why, in some types of collagen, molecules have evolved to be heterotrimers (consisting of more than one type of polypeptide chain, as in procollagen I for example) rather than homotrimers. The presence of a third chain distinct from the other two might permit further optimization of packing interactions in the C-propeptide trimer.

The question also arises of how specificity is determined in other procollagen types, both heterotrimers and homotrimers. With regard to procollagen I, we note differences in amino acid sequence in the interaction zone, compared to procollagen III, that are consistent with interactions between the proa1 (l) and proa2(l) chains (Fig. 9c). Specifically, the positively charged Arg142 is unique to procollagen III, as are the negatively charged residues Glu126, Asp127 and Asp130. By contrast, Asp127 is replaced by Lys in the proa2(l) chain, while Arg142 is replaced by Glu in the proa1 (l) chain. Such changes may contribute to the preferred association of the proa2(l) C- propeptide with the proa1 (l) C-propeptide in procollagen I. Further insights must await the structure determination of other procollagen C-propeptide trimers.

Though the structure of the C-propeptide trimer (excluding the stalk region) shows no obvious similarities with the globular regions of other extracellular trimeric proteins (Fig.18), detailed comparison using the DALI server (Holm et al., 2010) revealed some structural similarities with proteins containing the fibrinogen C-terminal domain (FBG), including angiopoietin-2, fibrinogens and ficolins. The most striking example is angiopoietin-2 (Fig. 19) where, despite a low sequence identity (< 15 %), most secondary structure elements are aligned in three dimensions, with the loop regions being much more variable. Structural similarity is particularly strong in the base region, including a conserved intra-chain disulphide bond. Whether this is a result of convergent or divergent evolution is unknown. It has previously been shown however that procollagen C-propeptides trimers are involved in tumor vascularization (Palmieri et al., 2008; Vincourt et al., 2010), through effects on endothelial cell migration and induction of VEGF. This structural similarity with FBG domain-containing proteins such as angiopoietin-2 may therefore give insights into the mechanisms of such additional functions of the C-propeptides.

II.4. C) Structural basis of related genetic disorders

Fibrillar procollagen C-propeptides are associated with several genetic disorders of connective tissues, including different forms of osteogenesis imperfecta (Ol; procollagen I), cartilage/bone dysplasias (procollagen II), and two types of Ehlers- Danlos syndrome, type I (affecting mainly skin; procollagen V) and type IV (leading to vascular deficiency; procollagen III). While hundreds of mutations throughout the length of the collagen molecule have been described, mutations in the C-propeptides are particularly important in view of their role in directing the assembly of the procollagen molecule. In general, such mutations can have two consequences: either the mutation prevents trimerization completely, leading (in heterozygotes) to haploinsufficiency of the affected collagen type, or the mutation leads to abnormal procollagen assembly, involving both wild type and mutant chains (Bateman et al., 2009; Byers et al., 2009). In total, 46 missense mutations (involving 38 distinct sites) have been identified in the C-propeptides of the proa1 (l), proa2(l), proal (II), proal (I II) and proal (V) chains (Table 3; Fig. 20). In most cases, the residue that is mutated in the other procollagen types is conserved in the proal (111) C-propeptide. This, as well as the strong similarity between the structure presented here and those predicted for the other procollagen types (Fig. 20), permits mapping of these mutations on to the procollagen III C-propeptide structure (Fig. 10). Note that mutation sites for the proa2(l) chain are not shown in Fig. 10 as all lead to mild/moderate forms of Ol, probably due to substitution by the proa1 (l) chain to form the trimer.

This mapping allows us to make the following general observations. First, mutations leading to mild to moderate phenotypes (shown in Fig. 10) generally involve surface located residues in regions not involved in inter-chain interactions, and therefore are unlikely to interfere with folding or trimerization. The only exception is the Cys81Trp mutation in the proa1 (l) chain, which disrupts disulfide bond formation with Cys243, yet leads to a relatively mild Ol phenotype (albeit associated with fractures of four ribs and a clavicle at birth) and gives rise to delayed trimerization and secretion of procollagen. Second, mutations leading to the most severe phenotypes (shown in Fig. 10) are found to be clustered in three regions of the molecule. These include the environment of the C-terminus of each chain, at the interface between the petal and the base. Mutations in this region are involved in intra-chain disulfide bonding (Cys81 - Cys243), inter-chain interactions (Leu245, Arg137) or stabilization of the hydrophobic core (Leu218). Among these, mutations near the C-terminus disrupt trimerization (Lim et al., 1998) and lead to severe/lethal forms of Ol (e.g. the Leu245Pro mutation in the proa1 (l) chain resulting in at least 200 bone fractures before four years of age (Oliver et al., 1996) or skeletal dysplasia (e.g. the Cys243Gly mutation in the proa1 (II) chain resulting in short stature and limbs and leading to death at 22 days from respiratory insufficiency (Zankl et al., 2005). In addition, many of the most severe phenotypes are associated with mutations in the region of the Cys151 -Cys196 disulfide bond, located near the tip of the petals, disrupting either intra-chain disulfide bonding or internal hydrophobic interactions. These include, for example, the Trp94Cys mutation in the proa1 (l) chain, leading to multiple fractures and perinatal death (Lamande et al., 1999), or the Tyr149Cys mutation in the proa1 (II) chain, also resulting in perinatal death, this time due to severe skeletal dysplasia (Nishimura et al., 2004). Finally, other severe/lethal mutations disrupt the base region, containing the remaining intra-chain disulfide bond (Cys41-Cys73) and the Ca²⁺ binding loop. For example, the Asp59His mutation in the proa1 (l) chain removes a Ca²⁺ binding ligand and disrupts inter-chain disulfide bonding, resulting in perinatal death from lethal Ol (Chessler et al., 1993). Missense mutations have also been reported in procollagens III (shown in Fig. 10) and V, again mostly in the base region (Table 4). For example, the Cys41 Ser mutation in the proa1 (V) chain disrupts disulfide-binding and leads to Ehlers-Danlos syndrome type I, characterized by skin and joint hyperextensibility, as well as poor wound healing (De Paepe et al., 1997). Such mutations underline the essential role of the highly conserved base region in the trimerization of fibrillar procollagens.

In conclusion, the long awaited structure of the procollagen III C-propeptide trimer presented here provides a paradigm for this family of protein domains with important implications for human disease.

Table 4. Positions and consequences of known missense mutations in the C-propeptides of the proa1 (l) (COL1A1 ), proa2(l) (COL1A2), proa1 (ll) (COL2A1 ), proa1 (III) (COL3A1 ) and proa1 (V) (COL5A1 ) chains. Numbering starts from the methionine at the translation initiation site, with corresponding positions in the procollagen III C-propeptide (CPIII) numbered from the BMP-1 cleavage site. Note that the disorders caused by the PLSD-T/SPD mutations in the proa1 (ll) chain are specific to the C-propeptide region, see https://oi.gene.le.ac.uk. Other sources : https://eds.gene.le.ac.uk, http://bioinf.umbc.edu/dmdm. Abbreviations: ACGII-HCG = achondrogenesis type II - hypochondrogenesis; ANFH = avascular necrosis of the femoral head; COMP = cartilage oligomeric matrix protein; CPIII = C-propeptide of procollagen III; EDS = Ehlers-Danlos syndrome; CRS = chain recognition sequence; 01 = osteogenesis imperfecta; PSACH = pseudoachondroplasia; PLSD-T = platyspondylic lethal skeletal dysplasia Torrance type (N.B. despite its name, this syndrome is not always lethal); PSACH = pseudoachondrodysplasia; SEDC = spondyloepiphyseal dysplasia congenita; SEDC-M = spondyloepiphyseal dysplasia congenita mild; SEDT = spondyloepiphyseal dysplasia tarda; SPD = spondyloperipheral dysplasia; TSAH = traumatic sub-arachnoid haemorrhage; VPED = vitreoretinopathy and phalangeal epiphyseal dysplasia.

Table A. Atomic coordinates of the crystal of form II

HEADER STRUCTURAL PROTEIN 4AE2

TITLE CRYSTAL STRUCTURE OF HUMAN FIBRILLAR PROCOLLAGEN TYPE III C-

TITLE 2 PROPEPTIDE TRIMER

COMPND MOL_ID: 1;

COMPND 2 MOLECULE: COLLAGEN ALPHA-1 (III) CHAIN;

COMPND 3 CHAIN: A, B, C;

COMPND 4 FRAGMENT: CPROPEPTIDE OF PROCOLLAGEN III, RESIDUES 919-1163;

COMPND 5 SYNONYM: PROCOLLAGEN III;

COMPND 6 ENGINEERED: YES;

COMPND 7 MUTATION: YES

SOURCE MOL_ID: 1;

SOURCE 2 ORGANISM_SCIENTIFIC : HOMO SAPIENS;

SOURCE 3 ORGANI SM_COMMON : HUMAN;

SOURCE 4 ORGANISM_TAXID: 9606;

SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS;

SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN;

SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606;

SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE : HEK 293T;

SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE : PLASMID;

SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PHLSEC

KEYWDS STRUCTURAL PROTEIN, FIBRILLAR COLLAGEN, EXTRACELLULAR MATRIX,

KEYWDS 2 FIBROSIS

EXPDTA X-RAY DIFFRACTION

AUTHOR J. M. BOURHIS, N.MARIANO, Y . ZHAO, K . HARLOS , E . Y . JONES , C . MOALI , N . AGHAJARI ,

AUTHOR 2

REVDAT 1 05-JAN-12 4AE2 0

JRNL AUTH J. M. BOURHIS, N.MARIANO, Y . ZHAO, K . HARLOS , E . Y . JONES , C . MOALI ,

JRNL AUTH 2 N. AGHAJARI, D. J. S . HULMES

JRNL TITL STRUCTURAL BASIS OF FIBRILLAR PROCOLLAGEN TRIMERIZATION AND

JRNL TITL 2 ASSOCIATED TISSUE DISORDERS

JRNL REF TO BE PUBLISHED

JRNL REFN

REMARK 1

REMARK 1 REFERENCE 1

REMARK 1 AUTH J. M. BOURHIS, N.MARIANO, Y . ZHAO, T . S . WALTER, K . HARLOS , C . MOALI ,

REMARK 1 AUTH 2 D. J. S . HULMES, N. AGHAJARI

REMARK 1 TITL LARGE SCALE PRODUCTION AND CRYSTALLISATION OF THE

REMARK 1 TITL 2 C-PROPEPTIDE TRIMER FROM PROCOLLAGEN III FOR HIGH

REMARK 1 TITL 3 RESOLUTION STRUCTURE DETERMINATION

REMARK 1 REF TO BE PUBLISHED

REMARK 1 REFN

REMARK 2

REMARK 2 1.68 ANGSTROMS.

REMARK 3

REMARK 3 REFINEMENT .

REMARK 3 PROGRAM REFMAC 5.6.0117

REMARK 3 AUTHORS MURSHUDOV, VAGIN, DODSON

REMARK 3

REMARK 3 REFINEMENT TARGET MAXIMUM LIKELIHOOD

REMARK 3

REMARK 3 DATA USED IN REFINEMENT.

REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) 1.68

REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) 61.27

REMARK 3 DATA CUTOFF (SIGMA(F)) NONE

REMARK 3 COMPLETENESS FOR RANGE (%) 96.24

REMARK 3 NUMBER OF REFLECTIONS 74058

REMARK 3

REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD THROUGHOUT

REMARK 3 FREE R VALUE TEST SET SELECTION RANDOM

REMARK 3 R VALUE (WORKING + TEST SET) 0 16376

REMARK 3 R VALUE (WORKING SET) 0 16102

REMARK 3 FREE R VALUE 0 21354

REMARK 3 FREE R VALUE TEST SET SIZE (%) 5 0

REMARK 3 FREE R VALUE TEST SET COUNT 3914

REMARK 3

REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN.

REMARK 3 TOTAL NUMBER OF BINS USED 20

REMARK 3 BIN RESOLUTION RANGE HIGH (A) 1.683

REMARK 3 BIN RESOLUTION RANGE LOW (A) 1.727

REMARK 3 REFLECTION IN BIN (WORKING SET) 5115

REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) 95.63

REMARK 3 BIN R VALUE (WORKING SET) 0.207

REMARK 3 BIN FREE R VALUE SET COUNT 269

REMARK 3 BIN FREE R VALUE 0.304

REMARK 3

REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.

REMARK 3 PROTEIN ATOMS : 5024

REMARK 3 NUCLEIC ACID ATOMS : 0

REMARK 3 HETEROGEN ATOMS : 23

REMARK 3 SOLVENT ATOMS : 398

REMARK 3

REMARK 3 B VALUES.

REMARK 3 FROM WILSON PLOT (A**2) : NULL

REMARK 3 MEAN B VALUE (OVERALL, A**2) : 21.855

REMARK 3 OVERALL ANISOTROPIC B VALUE.

REMARK 3 Bll (A**2) 0.11

REMARK 3 B22 (A**2) -0.09

REMARK 3 B33 (A**2) -0.01

REMARK 3 B12 (A**2) 0.00

REMARK 3 B13 (A**2) 0.00

REMARK 3 B23 (A**2) 0.00

REMARK 3

REMARK 3 ESTIMATED OVERALL COORDINATE ERROR

REMARK 3 ESU BASED ON R VALUE (A) : 0.130

REMARK 3 ESU BASED ON FREE R VALUE (A) : 0.100

REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A) : 0.067

REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2) : 4.440

REMARK 3

REMARK 3 CORRELATION COEFFICIENTS.

REMARK 3 CORRELATION COEFFICIENT FO-FC 0.964

REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.946

REMARK 3

REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT

REMARK 3 BOND LENGTHS REFINED ATOMS (A) 5184 ; 0.009 ; 0.020

REMARK 3 BOND LENGTHS OTHERS (A) NULL NULL NULL

REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES) 7023 ; 1.244 ; 1.945

REMARK 3 BOND ANGLES OTHERS (DEGREES) NULL NULL NULL

REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES) 640 ; 6.054 ; 5.000

REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES) 241 ; 34.460 ; 24.357

REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES) 842 ; 12.818 ;15.000

REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES) 26 ;16.362 ;15.000

REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3) 725 ; 0.084 ; 0.200

REMARK 3 GENERAL PLANES REFINED ATOMS (A) 4025 ; 0.005 ; 0.021

REMARK 3 GENERAL PLANES OTHERS (A) NULL NULL NULL

REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A) NULL NULL NULL

REMARK 3 NON-BONDED CONTACTS OTHERS (A) NULL NULL NULL

REMARK 3 NON-BONDED TORSION REFINED ATOMS (A) NULL NULL NULL

REMARK 3 NON-BONDED TORSION OTHERS (A) NULL NULL NULL REMARK 3 H-BOND (X...Y) REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 H-BOND (X...Y) OTHERS (A) NULL ; NULL ; NULL

REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 POTENTIAL METAL-ION OTHERS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY VDW REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY VDW OTHERS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY H-BOND OTHERS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY METAL-ION OTHERS (A) NULL ; NULL ; NULL

REMARK 3

REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT

REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3

REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT

REMARK 3 RIGID-BOND RESTRAINTS (A**2) 5184 ; 3.130 ; 3.000

REMARK 3 SPHERICITY; FREE ATOMS (A**2) 133 ; 24.217 ; 5.000

REMARK 3 SPHERICITY; BONDED ATOMS (A**2) 5320 ; 14.803 ; 5.000

REMARK 3

REMARK 3 NCS RESTRAINTS STATISTICS

REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL

REMARK 3

REMARK 3 TLS DETAILS

REMARK 3 NUMBER OF TLS GROUPS : NULL

REMARK 3

REMARK 3 BULK SOLVENT MODELLING.

REMARK 3 METHOD USED : MASK

REMARK 3 PARAMETERS FOR MASK CALCULATION

REMARK 3 VDW PROBE RADIUS : 1.20

REMARK 3 ION PROBE RADIUS : 0.80

REMARK 3 SHRINKAGE RADIUS : 0.80

REMARK 3

REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE

REMARK 3 RIDING POSITIONS.

REMARK 4

REMARK 4 4AE2 COMPLIES WITH FORMAT V. 3.30, 13-JUL-ll

REMARK 100

REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 05-JAN- 12.

REMARK 100 THE PDBE ID CODE IS EBI-50684.

REMARK 200

REMARK 200 EXPERIMENTAL DETAILS

REMARK 200 EXPERIMENT TYPE X-RAY DIFFRACTION

REMARK 200 DATE OF DATA COLLECTION 16-MAY-ll

REMARK 200 TEMPERATURE (KELVIN) 100

REMARK 200 PH 6.5

REMARK 200 NUMBER OF CRYSTALS USED 1

REMARK 200

REMARK 200 SYNCHROTRON (Y/N) Y

REMARK 200 RADIATION SOURCE DIAMOND

REMARK 200 BEAMLINE 103

REMARK 200 X-RAY GENERATOR MODEL NULL

REMARK 200 MONOCHROMATIC OR LAUE (M/L) M

REMARK 200 WAVELENGTH OR RANGE (A) 0.976

REMARK 200 MONOCHROMATOR NULL

REMARK 200 OPTICS NULL

REMARK 200

REMARK 200 DETECTOR TYPE CCD REMARK 200 DETECTOR MANUFACTURER ADSC

REMARK 200 INTENSITY-INTEGRATION SOFTWARE MOSFLM

REMARK 200 DATA SCALING SOFTWARE SCALA

REMARK 200

REMARK 200 NUMBER OF UNIQUE REFLECTIONS 78019

REMARK 200 RESOLUTION RANGE HIGH (A) 1.70

REMARK 200 RESOLUTION RANGE LOW (A) 61.20

REMARK 200 REJECTION CRITERIA (SIGMA(I)) 2.0

REMARK 200

REMARK 200 OVERALL .

REMARK 200 COMPLETENESS FOR RANGE (%) 96.6

REMARK 200 DATA REDUNDANCY 3.5

REMARK 200 R MERGE (I) 0.07

REMARK 200 R SYM (I) NULL

REMARK 200 <I/SIGMA(I)> FOR THE DATA SET 9.60

REMARK 200

REMARK 200 IN THE HIGHEST RESOLUTION SHELL.

REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) 1.70

REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) 61.00

REMARK 200 COMPLETENESS FOR SHELL (%) : 96.2

REMARK 200 DATA REDUNDANCY IN SHELL : 3.6

REMARK 200 R MERGE FOR SHELL (I) : 0.40

REMARK 200 R SYM FOR SHELL (I) : NULL

REMARK 200 <I/SIGMA(I)> FOR SHELL : 3.00

REMARK 200

REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH

REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT

REMARK 200 SOFTWARE USED: MOLREP

REMARK 200 STARTING MODEL: NULL

REMARK 200

REMARK 200 REMARK : NONE

REMARK 280

REMARK 280 CRYSTAL

REMARK 280 SOLVENT CONTENT, VS (%) : 39.9

REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS ** 3 /DA) : 2.0

REMARK 280

REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG 3350, 0.1 M BIS TRIS

REMARK 280 PROPANE PH 6.5, POTASSIUM NITRATE 0.2 M

REMARK 290

REMARK 290 CRYSTALLOGRAPHIC SYMMETRY

REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21

REMARK 290

REMARK 290 SYMOP SYMMETRY

REMARK 290 NNNMMM OPERATOR

REMARK 290 1555 Χ,Υ,Ζ

REMARK 290 2555 -X+l/2, -Y, Z+l/2

REMARK 290 3555 -X, Y+l/2, -Z+l/2

REMARK 290 4555 X+l/2, -Y+l/2, -Z

REMARK 290

REMARK 290 WHERE NNN -> OPERATOR NUMBER

REMARK 290 MMM -> TRANSLATION VECTOR

REMARK 290

REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS

REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM

REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY

REMARK 290 RELATED MOLECULES.

REMARK 290 SMTRY1 1 1. .000000 0. .000000 0. .000000 0. .00000

REMARK 290 SMTRY2 1 0. .000000 1. .000000 0. .000000 0. .00000

REMARK 290 SMTRY3 1 0. .000000 0. .000000 1. .000000 0. .00000

REMARK 290 SMTRY1 2 -1. .000000 0. .000000 0. .000000 38. .22500

REMARK 290 SMTRY2 2 0. .000000 -1. , 000000 0. , 000000 0. , 00000 REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 51.22000

REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0. 00000

REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 45. 18000

REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 51. 22000

REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 38. 22500

REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 45. 18000

REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0. 00000

REMARK 290

REMARK 290 REMARK: NULL

REMARK 300

REMARK 300 BIOMOLECULE 1

REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM

REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN

REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON

REMARK 300 BURIED SURFACE AREA.

REMARK 350

REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE ; KNOWN

REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE

REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS

REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND

REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.

REMARK 350

REMARK 350 BIOMOLECULE 1

REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC

REMARK 350 SOFTWARE USED: PISA

REMARK 350 TOTAL BURIED SURFACE AREA: 5190 ANGSTROM* * 2

REMARK 350 SURFACE AREA OF THE COMPLEX: 27710 ANGSTROM* * 2

REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -55.5 KCAL/MOL

REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C

REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0. 00000

REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0. 00000

REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0. 00000

REMARK 400

REMARK 400 COMPOUND

REMARK 400 ENGINEERED RESIDUE IN CHAIN A, ASN 1064 TO GLN

REMARK 400 ENGINEERED RESIDUE IN CHAIN B, ASN 1064 TO GLN

REMARK 400 ENGINEERED RESIDUE IN CHAIN C, ASN 1064 TO GLN

REMARK 465

REMARK 465 MISSING RES IDUES

REMARK 465 THE FOLLOWI NG RESIDUES WERE NOT LOCATED IN THE

REMARK 465 EXPERIMENT . (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN

REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE. )

REMARK 465

REMARK 465 M RES C S SSEQI

REMARK 465 GLU A -10

REMARK 465 THR A -9

REMARK 465 GLY A -8

REMARK 465 HIS A -7

REMARK 465 HIS A -6

REMARK 465 HIS A -5

REMARK 465 HIS A -4

REMARK 465 HIS A -3

REMARK 465 HIS A -2

REMARK 465 SER A -1

REMARK 465 ALA A 0

REMARK 465 ASP A 1

REMARK 465 GLU A 2

REMARK 465 PRO A 3

REMARK 465 MET A 4

REMARK 465 ASP A 5

REMARK 465 PHE A 6 REMARK 465 LYS A 7

REMARK 465 ILE A 8

REMARK 465 ASN A 9

REMARK 465 THR A 10

REMARK 465 ASP A 11

REMARK 465 GLU A 12

REMARK 465 ILE A 13

REMARK 465 MET A 14

REMARK 465 THR A 15

REMARK 465 SER A 16

REMARK 465 LEU A 17

REMARK 465 LYS A 18

REMARK 465 SER A 19

REMARK 465 VAL A 20

REMARK 465 ASN A 21

REMARK 465 GLY A 22

REMARK 465 GLN A 23

REMARK 465 ILE A 24

REMARK 465 GLU A 25

REMARK 465 SER A 26

REMARK 465 LEU A 27

REMARK 465 ILE A 28

REMARK 465 SER A 29

REMARK 465 SER A 98

REMARK 465 SER A 99

REMARK 465 ALA A 100

REMARK 465 GLU A 101

REMARK 465 GLU B -10

REMARK 465 THR B -9

REMARK 465 GLY B -8

REMARK 465 HIS B -7

REMARK 465 HIS B -6

REMARK 465 HIS B -5

REMARK 465 HIS B -4

REMARK 465 HIS B -3

REMARK 465 HIS B -2

REMARK 465 SER B -1

REMARK 465 ALA B 0

REMARK 465 ASP B 1

REMARK 465 GLU B 2

REMARK 465 PRO B 3

REMARK 465 MET B 4

REMARK 465 ASP B 5

REMARK 465 PHE B 6

REMARK 465 LYS B 7

REMARK 465 ILE B 8

REMARK 465 ASN B 9

REMARK 465 THR B 10

REMARK 465 ASP B 11

REMARK 465 GLU B 12

REMARK 465 ILE B 13

REMARK 465 MET B 14

REMARK 465 THR B 15

REMARK 465 SER B 16

REMARK 465 LEU B 17

REMARK 465 LYS B 18

REMARK 465 SER B 19

REMARK 465 VAL B 20

REMARK 465 ASN B 21

REMARK 465 GLY B 22

REMARK 465 GLN B 23 REMARK 465 ILE B 24

REMARK 465 GLU B 25

REMARK 465 SER B 26

REMARK 465 LEU B 27

REMARK 465 ILE B 28

REMARK 465 SER B 29

REMARK 465 ALA B 100

REMARK 465 GLU B 101

REMARK 465 GLU C -10

REMARK 465 THR C -9

REMARK 465 GLY C -8

REMARK 465 HIS C -7

REMARK 465 HIS C -6

REMARK 465 HIS C -5

REMARK 465 HIS C -4

REMARK 465 HIS C -3

REMARK 465 HIS C -2

REMARK 465 SER C -1

REMARK 465 ALA C 0

REMARK 465 ASP C 1

REMARK 465 GLU C 2

REMARK 465 PRO C 3

REMARK 465 MET C 4

REMARK 465 ASP C 5

REMARK 465 PHE C 6

REMARK 465 LYS C 7

REMARK 465 ILE C 8

REMARK 465 ASN C 9

REMARK 465 THR C 10

REMARK 465 ASP C 11

REMARK 465 GLU C 12

REMARK 465 ILE C 13

REMARK 465 MET C 14

REMARK 465 THR C 15

REMARK 465 SER C 16

REMARK 465 LEU C 17

REMARK 465 LYS C 18

REMARK 465 SER C 19

REMARK 465 VAL C 20

REMARK 465 ASN C 21

REMARK 465 GLY C 22

REMARK 465 GLN C 23

REMARK 465 ILE C 24

REMARK 465 GLU C 25

REMARK 465 SER C 26

REMARK 465 LEU C 27

REMARK 465 ILE C 28

REMARK 465 ASP C 97

REMARK 465 SER C 98

REMARK 465 SER C 99

REMARK 465 ALA C 100

REMARK 465 GLU C 101

REMARK 470

REMARK 470 MISSING ATOM

REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE) :

REMARK 470 M RES CSSEQI ATOMS

REMARK 470 LYS A 35 CG CD CE NZ

REMARK 470 LYS A 65 CD CE NZ

REMARK 470 ASP A 97 CG OD1 OD2 REMARK 470 GLU A 123 CG CD OE1 OE2

REMARK 470 LEU A 124 CG CD1 CD2

REMARK 470 GLU A 126 CG CD OE1 OE2

REMARK 470 GLU A 176 CG CD OE1 OE2

REMARK 470 ARG A 213 NE CZ NH1 NH2

REMARK 470 LYS B 35 CG CD CE NZ

REMARK 470 GLU B 76 CG CD OE1 OE2

REMARK 470 LYS B 103 CD CE NZ

REMARK 470 LYS B 214 CD CE NZ

REMARK 470 LYS C 35 CD CE NZ

REMARK 470 LYS C 103 CG CD CE NZ

REMARK 470 ASP C 112 CG OD1 OD2

REMARK 470 GLN C 160 CD OE1 NE2

REMARK 470 LYS C 198 CD CE NZ

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME I ASYMMETRIC UNIT

REMARK 500

REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE ; CONTACT.

REMARK 500

REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE

REMARK 500 O HOH A 2015 O HOH A 2016 1.91

REMARK 500 O HOH A 2152 O HOH A 2153 1.98

REMARK 500 O HOH B 2013 O HOH B 2014 1.36

REMARK 500

REMARK 500 REMARK : NULL

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: TORSION ANGLES

REMARK 500

REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS :

REMARK 500 (M=MODEL NUMBER; RES= RESIDUE NAME; C=CHAIN IDENTIFIER;

REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE) .

REMARK 500

REMARK 500 STANDARD TABLE:

REMARK 500 FORMAT : (10X, 13, IX, A3, IX, Al, 14, Al , 4X, F7.2, 3X, F7.2)

REMARK 500

REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND ) TA JONES (1996) . . PHI/PSI-

REMARK 500 CHOLOGY : RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400

REMARK 500

REMARK 500 M RES CSSEQI PSI PHI

REMARK 500 ASP A 31 -5 .08 -153. 03

REMARK 500 GLN A 62 -142 .15 50. 11

REMARK 500 ASN A 121 102 .14 -56. 32

REMARK 500 PRO A 122 1 .58 -63. 38

REMARK 500 TYR A 157 -83 .88 -141. 85

REMARK 500 SER A 204 -159 .69 -148. 28

REMARK 500 LYS A 214 78 .50 -108. 18

REMARK 500 GLN B 62 -140 .87 52. 79

REMARK 500 ASN B 121 105 .88 -52. 47

REMARK 500 TYR B 157 -88 .49 -140. 08

REMARK 500 GLN C 62 -136 .79 51. 67

REMARK 500 TYR C 157 -86 .55 -136. 15

REMARK 500 GLU C 176 -16 .85 72. 85

REMARK 500 SER C 204 -159 .24 -147. 38

REMARK 500

REMARK 500 REMARK : NULL

REMARK 525

REMARK 525 SOLVENT

REMARK 525

REMARK 525 THE FOLLOWING SOLVENT MOLECULES LIE FARTHER THAN EXPECTED REMARK 525 FROM THE PROTEIN OR NUCLEIC ACID MOLECULE AND ARE

REMARK 525 ASSOCIATED WITH A SYMMETRY RELATED MOLECULE (M=MODEL

REMARK 525 NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE REMARK 525 NUMBER; I=INSERTION CODE) : THESE HAVE BEEN REPOSITIONED

REMARK 525 BY APPLYING THE SYMMETRY TRANSFORMATION INDICATED.

REMARK 525

REMARK 525 RES CSSEQI ORIGINAL COORDINATES SYMMETRY TRANS . DIST REMARK 525 X Y z

REMARK 525 HOH D 228 -2 .302 -40. .848 -8. .936 003 554 2.60 REMARK 525 HOH D 109 17 .700 -26. .243 -16. .298 003 554 2.71 REMARK 525 HOH D 223 11 .122 -27. .948 -14. .596 003 554 2.61 REMARK 525 HOH D 137 21 .889 -26. .014 -18. .306 003 554 2.79 REMARK 525 HOH D 258 -0 .347 32 , .204 -9. .602 003 544 3.35 REMARK 525 HOH D 387 14 .004 -30. .050 -12. .344 003 554 2.72 REMARK 525 HOH D 227 -27 .339 17 , .514 -29. .005 003 544 3.65 REMARK 525 HOH D 389 -25 .855 17 , .904 -33. .605 003 544 3.12 REMARK 525 HOH D 377 6 .998 5, .224 -47. .429 003 544 3.56 REMARK 525 HOH D 274 -4 .784 10 , .292 -38. .279 003 544 2.68 REMARK 620

REMARK 620 METAL COORDINATION

REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;

REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE)

REMARK 620

REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL

REMARK 620 CA A 246 CA

REMARK 620 N RES CSSEQI ATOM

REMARK 620 1 ASP A 59 OD1

REMARK 620 2 ASP A 67 OD1 81 .3

REMARK 620 3 ASN A 61 OD1 72 .6 96. 3

REMARK 620 4 ASP A 59 OD2 51 .7 107. 1 113. 1

REMARK 620 5 CYS A 64 O 125 .1 87. 4 162. 3 82.0

REMARK 620 6 GLN A 62 O 109 .0 169. 4 84. 8 82.0 88. 6

REMARK 620 7 HOH A2037 O 146 .7 80. 1 82. 2 161.6 81. 4 89.6

REMARK 620 N 1 2 3 4 5 6

REMARK 620

REMARK 620 COORDINATION ANGLES FOR: : M RES CSSEQI METAL

REMARK 620 CA B 246 CA

REMARK 620 N RES CSSEQI ATOM

REMARK 620 1 GLN B 62 O

REMARK 620 2 HOH A2019 O 81 .6

REMARK 620 3 ASP B 59 OD1 119 .4 148. 3

REMARK 620 4 ASN B 61 OD1 84 .4 81. 0 78. 1

REMARK 620 5 ASP B 67 OD1 157 .9 77. 2 82. 5 98.4

REMARK 620 6 CYS B 64 O 91 .1 83. 7 116. 8 164.5 80. 4

REMARK 620 7 ASP B 59 OD2 79 .9 158. 1 53. 3 108.8 119. 1 84.9

REMARK 620 N 1 2 3 4 5 6

REMARK 620

REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL

REMARK 620 CA C 246 CA

REMARK 620 N RES CSSEQI ATOM

REMARK 620 1 ASP C 59 OD2

REMARK 620 2 GLN C 62 O 80 .5

REMARK 620 3 GLN C 62 O 79 .7 1. 4

REMARK 620 4 ASP C 59 OD1 52 .7 117. 0 115.7

REMARK 620 5 ASN C 61 OD1 108 .6 84. 3 83.5 75.8

REMARK 620 6 ASP C 67 OD1 116 .1 161. 7 162.8 80.8 96.8

REMARK 620 7 HOH B2016 O 158 .6 83. 4 84.4 148.6 83.4 78.6

REMARK 620 8 CYS C 64 O 86 .0 92. 1 93.2 119.4 164.0 81.9 80.7 REMARK 620 N 1 2 3 4 5 6 7 REMARK 800

REMARK 800 SITE REMARK 800 SITE IDENTIFIER: AC1

REMARK 800 EVIDENCE CODE: SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE CA A 246

REMARK 800

REMARK 800 SITE IDENTIFIER: AC2

REMARK 800 EVIDENCE CODE: SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE N03 Al 246

REMARK 800

REMARK 800 SITE IDENTIFIER: AC3

REMARK 800 EVIDENCE CODE: SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE N03 Al 247

REMARK 800

REMARK 800 SITE IDENTIFIER: AC4

REMARK 800 EVIDENCE CODE: SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE CA B 246

REMARK 800

REMARK 800 SITE IDENTIFIER: AC5

REMARK 800 EVIDENCE CODE: SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE N03 Bl 246

REMARK 800

REMARK 800 SITE IDENTIFIER: AC6

REMARK 800 EVIDENCE CODE: SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE N03 Bl 247

REMARK 800

REMARK 800 SITE IDENTIFIER: AC7

REMARK 800 EVIDENCE CODE: SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE CA C 246

REMARK 800

REMARK 800 SITE IDENTIFIER: AC8

REMARK 800 EVIDENCE CODE: SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE N03 CI 246

REMARK 900

REMARK 900 RELATED ENTRIES

REMARK 900 RELATED ID: 2V53 RELATED ) DB: PDB

REMARK 900 CRYSTAL STRUCTURE OF A SPARC-COLLAGEN COMPLEX

DBREF 4AE 2 A 1 245 UNP P02461 C03A1 HUMAN 919 1163

DBREF 4AE 2 B 1 245 UNP P02461 C03A1 HUMAN 919 1163

DBREF 4AE 2 C 1 245 UNP P02461 C03A1 HUMAN 919 1163

SEQADV 4AE 2 GLU A -10 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 THR A -9 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 GLY A -8 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS A -7 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS A -6 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS A -5 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS A -4 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS A -3 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS A -2 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 SER A -1 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 ALA A 0 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 GLN A 132 UNP P02461 HIS ; 1050 CONFLICT

SEQADV 4AE 2 GLN A 146 UNP P02461 ASK [ 1064 ENGINEERED MUTATION

SEQADV 4AE 2 GLU B -10 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 THR B -9 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 GLY B -8 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS B -7 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS B -6 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS B -5 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS B -4 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS B -3 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 HIS B -2 UNP P02461 EXPRESSION TAG

SEQADV 4AE 2 SER B -1 UNP P02461 EXPRESSION TAG SEQADV 4AE2 ALA B 0 U P P02461 EXPRESSION TAG

SEQADV 4AE2 GLN B 132 U P P02461 HIS 1050 CONFLICT

SEQADV 4AE2 GLN B 146 UNP P02461 ASN 1064 ENGINEERED MUTATION

SEQADV 4AE2 GLU C -10 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 THR C -9 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 GLY C -8 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 HIS C -7 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 HIS C -6 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 HIS C -5 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 HIS C -4 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 HIS C -3 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 HIS C -2 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 SER C -1 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 ALA C 0 UNP P02461 EXPRESSION TAG

SEQADV 4AE2 GLN C 132 UNP P02461 HIS 1050 CONFLICT

SEQADV 4AE2 GLN C 146 UNP P02461 ASN 1064 ENGINEERED MUTATION

SEQRES 1 A 256 GLU THR GLY HIS HIS HIS HIS HIS HIS SER ALA ASP GLU

SEQRES 2 A 256 PRO MET ASP PHE LYS ILE ASN THR ASP GLU ILE MET THR

SEQRES 3 A 256 SER LEU LYS SER VAL ASN GLY GLN ILE GLU SER LEU ILE

SEQRES 4 A 256 SER PRO ASP GLY SER ARG LYS ASN PRO ALA ARG ASN CYS

SEQRES 5 A 256 ARG ASP LEU LYS PHE CYS HIS PRO GLU LEU LYS SER GLY

SEQRES 6 A 256 GLU TYR TRP VAL ASP PRO ASN GLN GLY CYS LYS LEU ASP

SEQRES 7 A 256 ALA ILE LYS VAL PHE CYS ASN MET GLU THR GLY GLU THR

SEQRES 8 A 256 CYS ILE SER ALA ASN PRO LEU ASN VAL PRO ARG LYS HIS

SEQRES 9 A 256 TRP TRP THR ASP SER SER ALA GLU LYS LYS HIS VAL TRP

SEQRES 10 A 256 PHE GLY GLU SER MET ASP GLY GLY PHE GLN PHE SER TYR

SEQRES 11 A 256 GLY ASN PRO GLU LEU PRO GLU ASP VAL LEU ASP VAL GLN

SEQRES 12 A 256 LEU ALA PHE LEU ARG LEU LEU SER SER ARG ALA SER GLN

SEQRES 13 A 256 GLN ILE THR TYR HIS CYS LYS ASN SER ILE ALA TYR MET

SEQRES 14 A 256 ASP GLN ALA SER GLY ASN VAL LYS LYS ALA LEU LYS LEU

SEQRES 15 A 256 MET GLY SER ASN GLU GLY GLU PHE LYS ALA GLU GLY ASN

SEQRES 16 A 256 SER LYS PHE THR TYR THR VAL LEU GLU ASP GLY CYS THR

SEQRES 17 A 256 LYS HIS THR GLY GLU TRP SER LYS THR VAL PHE GLU TYR

SEQRES 18 A 256 ARG THR ARG LYS ALA VAL ARG LEU PRO ILE VAL ASP ILE

SEQRES 19 A 256 ALA PRO TYR ASP ILE GLY GLY PRO ASP GLN GLU PHE GLY

SEQRES 20 A 256 VAL ASP VAL GLY PRO VAL CYS PHE LEU

SEQRES 1 B 256 GLU THR GLY HIS HIS HIS HIS HIS HIS SER ALA ASP GLU

SEQRES 2 B 256 PRO MET ASP PHE LYS ILE ASN THR ASP GLU ILE MET THR

SEQRES 3 B 256 SER LEU LYS SER VAL ASN GLY GLN ILE GLU SER LEU ILE

SEQRES 4 B 256 SER PRO ASP GLY SER ARG LYS ASN PRO ALA ARG ASN CYS

SEQRES 5 B 256 ARG ASP LEU LYS PHE CYS HIS PRO GLU LEU LYS SER GLY

SEQRES 6 B 256 GLU TYR TRP VAL ASP PRO ASN GLN GLY CYS LYS LEU ASP

SEQRES 7 B 256 ALA ILE LYS VAL PHE CYS ASN MET GLU THR GLY GLU THR

SEQRES 8 B 256 CYS ILE SER ALA ASN PRO LEU ASN VAL PRO ARG LYS HIS

SEQRES 9 B 256 TRP TRP THR ASP SER SER ALA GLU LYS LYS HIS VAL TRP

SEQRES 10 B 256 PHE GLY GLU SER MET ASP GLY GLY PHE GLN PHE SER TYR

SEQRES 11 B 256 GLY ASN PRO GLU LEU PRO GLU ASP VAL LEU ASP VAL GLN

SEQRES 12 B 256 LEU ALA PHE LEU ARG LEU LEU SER SER ARG ALA SER GLN

SEQRES 13 B 256 GLN ILE THR TYR HIS CYS LYS ASN SER ILE ALA TYR MET

SEQRES 14 B 256 ASP GLN ALA SER GLY ASN VAL LYS LYS ALA LEU LYS LEU

SEQRES 15 B 256 MET GLY SER ASN GLU GLY GLU PHE LYS ALA GLU GLY ASN

SEQRES 16 B 256 SER LYS PHE THR TYR THR VAL LEU GLU ASP GLY CYS THR

SEQRES 17 B 256 LYS HIS THR GLY GLU TRP SER LYS THR VAL PHE GLU TYR

SEQRES 18 B 256 ARG THR ARG LYS ALA VAL ARG LEU PRO ILE VAL ASP ILE

SEQRES 19 B 256 ALA PRO TYR ASP ILE GLY GLY PRO ASP GLN GLU PHE GLY

SEQRES 20 B 256 VAL ASP VAL GLY PRO VAL CYS PHE LEU

SEQRES 1 C 256 GLU THR GLY HIS HIS HIS HIS HIS HIS SER ALA ASP GLU

SEQRES 2 C 256 PRO MET ASP PHE LYS ILE ASN THR ASP GLU ILE MET THR

SEQRES 3 C 256 SER LEU LYS SER VAL ASN GLY GLN ILE GLU SER LEU ILE

SEQRES 4 C 256 SER PRO ASP GLY SER ARG LYS ASN PRO ALA ARG ASN CYS

SEQRES 5 C 256 ARG ASP LEU LYS PHE CYS HIS PRO GLU LEU LYS SER GLY SEQRES 6 C 256 GLU TYR TRP VAL ASP PRO ASN GLN GLY CYS LYS LEU ASP

SEQRES 7 C 256 ALA ILE LYS VAL PHE CYS ASN MET GLU THR GLY GLU THR

SEQRES 8 C 256 CYS ILE SER ALA ASN PRO LEU ASN VAL PRO ARG LYS HIS

SEQRES 9 C 256 TRP TRP THR ASP SER SER ALA GLU LYS LYS HIS VAL TRP

SEQRES 10 C 256 PHE GLY GLU SER MET ASP GLY GLY PHE GLN PHE SER TYR

SEQRES 11 C 256 GLY ASN PRO GLU LEU PRO GLU ASP VAL LEU ASP VAL GLN

SEQRES 12 C 256 LEU ALA PHE LEU ARG LEU LEU SER SER ARG ALA SER GLN

SEQRES 13 C 256 GLN ILE THR TYR HIS CYS LYS ASN SER ILE ALA TYR MET

SEQRES 14 C 256 ASP GLN ALA SER GLY ASN VAL LYS LYS ALA LEU LYS LEU

SEQRES 15 C 256 MET GLY SER ASN GLU GLY GLU PHE LYS ALA GLU GLY ASN

SEQRES 16 C 256 SER LYS PHE THR TYR THR VAL LEU GLU ASP GLY CYS THR

SEQRES 17 C 256 LYS HIS THR GLY GLU TRP SER LYS THR VAL PHE GLU TYR

SEQRES 18 C 256 ARG THR ARG LYS ALA VAL ARG LEU PRO ILE VAL ASP ILE

SEQRES 19 C 256 ALA PRO TYR ASP ILE GLY GLY PRO ASP GLN GLU PHE GLY

SEQRES 20 C 256 VAL ASP VAL GLY PRO VAL CYS PHE LEU

HET CA A 246 1

HET N03 A1246 4

HET N03 A1247 4

HET CA B 246 1

HET N03 B1246 4

HET N03 B1247 4

HET CA C 246 1

HET N03 C1246 4

HETNAM CA CALCIUM ION

HETNAM N03 NITRATE ION

FORMUL 4 CA 3 (CA 2+ )

FORMUL 5 N03 5 (N 03 : 1-)

FORMUL 6 HOH *398 (H2 O)

HELIX 1 1 ASN A 40 HIS A 48 1 9

HELIX 2 2 CYS A 64 ALA A 68 5 5

HELIX 3 3 TRP A 106 MET A 111 1 6

HELIX 4 4 PRO A 125 SER A 140 1 16

HELIX 5 5 LYS A 214 LEU A 218 5 5

HELIX 6 6 ASN B 40 HIS B 48 1 9

HELIX 7 7 CYS B 64 ALA B 68 5 5

HELIX 8 8 TRP B 106 MET B 111 1 6

HELIX 9 9 PRO B 125 SER B 140 1 16

HELIX 10 10 LYS B 214 LEU B 218 5 5

HELIX 11 11 ASN C 40 HIS C 48 1 9

HELIX 12 12 CYS C 64 ALA C 68 5 5

HELIX 13 13 TRP C 106 MET C 111 1 6

HELIX 14 14 PRO C 125 LEU C 139 1 15

HELIX 15 15 LYS C 214 LEU C 218 5 5

SHEET 1 AA 7 GLY A 54 VAL A 58 0

SHEET 2 AA 7 ILE A 69 ASN A 74 - ^■1 O ILE A 69 N VAL A 58

SHEET 3 AA 7 GLU A 79 ILE A 82 - ^■1 O GLU A 79 N ASN A 74

SHEET 4 AA 7 GLU A 234 PHE A 244 - ^■1 O VAL A 242 N ILE A 82

SHEET 5 AA 7 ALA A 143 LYS A 152 - ^■1 O SER A 144 N CYS A 243

SHEET 6 AA 7 TRP A 203 THR . A 212 - ^■1 O SER A 204 N CYS A 151

SHEET 7 AA 7 THR A 190 ASP A 194 - ^■1 O THR A 190 N GLU A 209

SHEET 1 AB 5 GLY A 54 VAL A 58 0

SHEET 2 AB 5 ILE A 69 ASN A 74 - ^■1 O ILE A 69 N VAL A 58

SHEET 3 AB 5 GLU A 79 ILE A 82 - ^■1 O GLU A 79 N ASN A 74

SHEET 4 AB 5 GLU A 234 PHE A 244 - ^■1 O VAL A 242 N ILE A 82

SHEET 5 AB 5 ASN A 88 LYS A 92 - ^■1 O VAL A 89 N VAL A 237

SHEET 1 AC 3 GLU A 178 PHE A 179 0

SHEET 2 AC 3 LYS A 170 MET A 172 - ^■1 O LEU A 171 N PHE A 179

SHEET 3 AC 3 ASP A 222 ALA . A 224 - ^■1 O ASP A 222 N MET A 172

SHEET 1 BA 7 GLY B 54 VAL B 58 0

SHEET 2 BA 7 ILE B 69 ASN B 74 - ^■1 O ILE B 69 N VAL B 58

SHEET 3 BA 7 GLU B 79 ILE B 82 - ^■1 O GLU B 79 N ASN B 74 SHEET 4 BA 7 GLU B 234 PHE B 244 -1 0 VAL B 242 N ILE B 82

SHEET 5 BA 7 ALA B 143 LYS B 152 -1 0 SER B 144 N CYS B 243

SHEET 6 BA 7 TRP B 203 THR B 212 -1 0 SER B 204 N CYS B 151

SHEET 7 BA 7 THR B 190 ASP B 194 -1 0 THR B 190 N GLU B 209

SHEET 1 BB 5 GLY B 54 VAL B 58 nu

SHEET 2 BB 5 ILE B 69 ASN B 74 -1 0 ILE B 69 N VAL B 58

SHEET 3 BB 5 GLU B 79 ILE B 82 -1 0 GLU B 79 N ASN B 74

SHEET 4 BB 5 GLU B 234 PHE B 244 -1 0 VAL B 242 N ILE B 82

SHEET 5 BB 5 ASN B 88 LYS B 92 -1 0 VAL B 89 N VAL B 237

SHEET 1 BC 3 GLU B 178 PHE B 179 nu

SHEET 2 BC 3 LYS B 170 MET B 172 -1 0 LEU B 171 N PHE B 179

SHEET 3 BC 3 ASP B 222 ALA B 224 -1 0 ASP B 222 N MET B 172

SHEET 1 CA 7 GLY C 54 VAL C 58 nu

SHEET 2 CA 7 ILE C 69 CYS C 73 -1 0 ILE C 69 N VAL C 58

SHEET 3 CA 7 THR C 80 ILE C 82 -1 0 CYS C 81 N PHE C 72

SHEET 4 CA 7 GLU C 234 LEU C 245 -1 0 VAL C 242 N ILE C 82

SHEET 5 CA 7 ARG C 142 LYS C 152 -1 0 ARG C 142 N LEU C 245

SHEET 6 CA 7 TRP C 203 THR C 212 -1 0 SER C 204 N CYS C 151

SHEET 7 CA 7 THR C 190 ASP C 194 -1 0 THR C 190 N GLU C 209

SHEET 1 CB 5 GLY C 54 VAL C 58 nu

SHEET 2 CB 5 ILE C 69 CYS C 73 -1 0 ILE C 69 N VAL C 58

SHEET 3 CB 5 THR C 80 ILE C 82 -1 0 CYS C 81 N PHE C 72

SHEET 4 CB 5 GLU C 234 LEU C 245 -1 0 VAL C 242 N ILE C 82

SHEET 5 CB 5 ASN C 88 LYS C 92 -1 0 VAL C 89 N VAL C 237

SHEET 1 CC 3 GLU C 178 PHE C 179 0

SHEET 2 CC 3 LYS C 170 MET C 172 O LEU C 171 N PHE C 179

SHEET 3 CC 3 ASP C 222 ALA C 224 O ASP C 222 N MET C 172

SSBOND 1 CYS A 41 CYS A 73 1555 1555 2. .04

SSBOND 2 CYS A 47 CYS B 64 1555 1555 2 , .03

SSBOND 3 CYS A 64 CYS C 47 1555 1555 2. .04

SSBOND 4 CYS A 81 CYS A 243 1555 1555 2. .10

SSBOND 5 CYS A 151 CYS A 196 1555 1555 2. .05

SSBOND 6 CYS B 41 CYS B 73 1555 1555 2. .05

SSBOND 7 CYS B 47 CYS C 64 1555 1555 2. .04

SSBOND 8 CYS B 81 CYS B 243 1555 1555 2. .08

SSBOND 9 CYS B 151 CYS B 196 1555 1555 2. .04

SSBOND 10 CYS C 41 CYS C 73 1555 1555 2. .04

SSBOND 11 CYS C 81 CYS C 243 1555 1555 2. .10

SSBOND 12 CYS C 151 CYS C 196 1555 1555 2. .04

LINK CA CA A 246 OD1 ASP A 59 1555 1555 2. .47

LINK CA CA A 246 OD1 ASP A 67 1555 1555 2 , .34

LINK CA CA A 246 OD1 ASN A 61 1555 1555 2. .31

LINK CA CA A 246 OD2 ASP A 59 1555 1555 2. .57

LINK CA CA A 246 O CYS A 64 1555 1555 2. .31

LINK CA CA A 246 O GLN A 62 1555 1555 2. .28

LINK CA CA A 246 O HOH A2037 1555 1555 2. .43

LINK CA CA B 246 O GLN B 62 1555 1555 2. .30

LINK CA CA B 246 O HOH A2019 1555 1555 2. .43

LINK CA CA B 246 OD1 ASP B 59 1555 1555 2. .36

LINK CA CA B 246 OD1 ASN B 61 1555 1555 2 , .30

LINK CA CA B 246 OD1 ASP B 67 1555 1555 2. .33

LINK CA CA B 246 O CYS B 64 1555 1555 2. .30

LINK CA CA B 246 OD2 ASP B 59 1555 1555 2. .49

LINK CA CA C 246 O AGLN C 62 1555 1555 2. .29

LINK CA CA C 246 O BGLN C 62 1555 1555 2. .29

LINK CA CA C 246 OD1 ASP C 59 1555 1555 2. .44

LINK CA CA C 246 OD1 ASN C 61 1555 1555 2. .33

LINK CA CA C 246 OD1 ASP C 67 1555 1555 2. .31

LINK CA CA C 246 O HOH B2016 1555 1555 2. .36

LINK CA CA C 246 O CYS C 64 1555 1555 2. .19

LINK CA CA C 246 OD2 ASP C 59 1555 1555 2. .51 CISPEP 1 ASN A 85 PRO A 86 0 1.77

CISPEP 2 LEU A 218 PRO A 219 0 2. 37

CISPEP 3 ASN B 85 PRO B 86 0 2. 44

CISPEP 4 LEU B 218 PRO B 219 0 0. 76

CISPEP 5 ASN C 85 PRO C 86 0 1. 82

CISPEP 6 LEU C 218 PRO C 219 0 5. 60

SITE 1 AC1 6 ASP A 59 ASN A 61 GLN A 62 CYS A 64

SITE 2 AC1 6 ASP A 67 HOH A2037

SITE 1 AC2 8 PRO A 30 ALA A 38 ASP A 43 LEU A 44

SITE 2 AC2 8 CYS A 47 HIS A 48 HOH A2007 CYS B 64

SITE 1 AC3 8 HIS A 93 TRP A 94 TRP A 95 ILE A 228

SITE 2 AC3 8 GLY A 229 GLN A 233 GLU A 234 PHE A 235

SITE 1 AC4 6 HOH A2019 ASP B 59 ASN B 61 GLN B 62

SITE 2 AC4 6 CYS B 64 ASP B 67

SITE 1 AC5 9 LYS B 92 HIS B 93 TRP B 94 TRP B 95

SITE 2 AC5 9 ILE B 228 GLY B 229 GLN B 233 GLU B 234

SITE 3 AC5 9 PHE B 235

SITE 1 AC6 8 PRO B 30 ALA B 38 ASP B 43 LEU B 44

SITE 2 AC6 8 CYS B 47 HIS B 48 HOH B2006 CYS C 64

SITE 1 AC7 6 HOH B2016 ASP C 59 ASN C 61 GLN C 62

SITE 2 AC7 6 CYS C 64 ASP C 67

SITE 1 AC8 9 CYS A 64 SER C 29 PRO C 30 ALA C 38

SITE 2 AC8 9 ASP C 43 CYS C 47 HIS C 48 HOH C2008

SITE 3 AC8 9 HOH C2127

CRYST1 76.450 90. 36C 102.. 440 90.00 90.00 90.00 P 21 21 21

0RIGX1 1.000000 0. 000000 0.000000 0. 00000

0RIGX2 0.000000 1. 000000 0.000000 0. 00000

0RIGX3 0.000000 0. 000000 1.000000 0. 00000

SCALE1 0.013080 0. 000000 0.000000 0. 00000

SCALE2 0.000000 0. 011067 0.000000 0. 00000

SCALE3 0.000000 0. 000000 0.009762 0. 00000

ATOM 1 N PRO A 30 20.890 3. 292 -35 .201 1 .00 37 .75 N

ANISOU 1 N PRO A 30 5363 5066 3914 -576 -288 298 N

ATOM 2 CA PRO A 30 20.049 2. 792 -36 .268 1 .00 33 .27 C

ANISOU 2 CA PRO A 30 3848 4623 4168 -193 183 203 C

ATOM 3 C PRO A 30 19.557 3. 917 -37 .105 1 .00 38 .10 C

ANISOU 3 C PRO A 30 5273 4170 5033 -290 262 476 C

ATOM 4 O PRO A 30 20.097 4. 999 -36 .972 1 .00 39 .89 O

ANISOU 4 O PRO A 30 5590 4156 5410 -132 732 -103 O

ATOM 5 CB PRO A 30 18.887 2. 148 -35 .512 1 .00 28 .49 C

ANISOU 5 CB PRO A 30 3612 4098 3111 -1 -176 235 C

ATOM 6 CG PRO A 30 19.235 2. 210 -34 .083 1 .00 28 .13 C

ANISOU 6 CG PRO A 30 2978 4563 3147 -379 -147 -275 C

ATOM 7 CD PRO A 30 20.687 2. 486 -33 .997 1 .00 29 .04 C

ANISOU 7 CD PRO A 30 2897 4471 3666 -307 561 -66 C

ATOM 8 N ASP A 31 18.571 3. 602 -37 .934 1 .00 38 .30 N

ANISOU 8 N ASP A 31 3694 5535 5320 -300 707 995 N

ATOM 9 CA ASP A 31 18.040 4. 481 -38 .953 1 .00 34 .41 C

ANISOU 9 CA ASP A 31 3780 4657 4636 178 1391 268 C

ATOM 10 C ASP A 31 16.568 4. 207 -39 .325 1 .00 31 .53 C

ANISOU 10 C ASP A 31 3766 4125 4086 100 1332 408 C

ATOM 11 O ASP A 31 15.998 4. 961 -40 .086 1 .00 34 .11 O

ANISOU 11 O ASP A 31 5051 3878 4029 -839 1345 1250 O

ATOM 12 CB ASP A 31 18.973 4. 504 -40 .184 1 .00 35 .64 C

ANISOU 12 CB ASP A 31 4360 4119 5061 -798 1841 -823 C

ATOM 13 CG ASP A 31 18.691 3. 399 -41 .193 1 .00 36 .97 C

ANISOU 13 CG ASP A 31 4827 3900 5319 256 1799 - 1002 c

ATOM 14 OD1 ASP A 31 18.205 2. 314 -40 .824 1 .00 35 .06 0

ANISOU 14 OD1 ASP A 31 3740 4257 5322 516 1272 -57 0

ATOM 15 OD2 ASP A 31 18.999 3. 633 -42 .382 1 .00 45 .16 0

ANISOU 15 OD2 ASP A 31 6367 5638 5152 -599 778 -273 0 ATOM 16 N GLY A 32 15.951 3,.153 -38..778 1..00 27..91 N

ANISOU 16 N GLY A 32 2729 4258 3616 184 856 315 N

ATOM 17 CA GLY A 32 14.512 2, .917 -38. .991 1. .00 20. .35 C

ANISOU 17 CA GLY A 32 2666 2704 2361 545 711 896 C

ATOM 18 C GLY A 32 14.128 2, .055 -40. .182 1. .00 22. .72 C

ANISOU 18 C GLY A 32 2664 3093 2872 402 831 450 C

ATOM 19 O GLY A 32 12.939 1. .888 -40. .500 1. .00 22. .90 O

ANISOU 19 O GLY A 32 2826 3497 2376 786 389 537 O

ATOM 20 N SER A 33 15.133 1. .528 -40. .867 1. .00 22. .88 N

ANISOU 20 N SER A 33 2774 2627 3292 799 438 59 N

ATOM 21 CA SER A 33 14.915 0, .540 -41. .911 1. .00 23. .31 C

ANISOU 21 CA SER A 33 2963 2799 3094 350 596 84 C

ATOM 22 C SER A 33 14.697 -0. .830 -41. .263 1. .00 23. .33 C

ANISOU 22 C SER A 33 3757 2864 2241 552 503 15 C

ATOM 23 O SER A 33 15.016 -1. .023 -40. .091 1. .00 23. .08 O

ANISOU 23 O SER A 33 3215 3209 2345 259 390 219 O

ATOM 24 CB SER A 33 16.123 0, .498 -42. .838 1. .00 26. .55 C

ANISOU 24 CB SER A 33 2770 3875 3441 546 624 624 C

ATOM 25 OG SER A 33 17.263 0, .038 -42. .125 1. .00 27. .07 0

ANISOU 25 OG SER A 33 2420 4363 3502 1100 1142 701 0

ATOM 26 N ARG A 34 14.163 -1. .785 -42. .023 1. .00 24. .93 N

ANISOU 26 N ARG A 34 3551 2620 3300 302 549 -94 N

ATOM 27 CA ARG A 34 13.952 -3. .131 -41. .495 1. .00 25. .37 C

ANISOU 27 CA ARG A 34 3797 3069 2774 -117 732 78 C

ATOM 28 C ARG A 34 15.243 -3. .805 -40. .992 1. .00 26. .59 C

ANISOU 28 C ARG A 34 4178 3128 2796 239 667 ^■116 C

ATOM 29 O ARG A 34 15.238 -4. .501 -39. .978 1. .00 29. .06 O

ANISOU 29 O ARG A 34 4312 2965 3763 419 Ill 450 O

ATOM 30 CB ARG A 34 13.268 -4. .004 -42. .532 1. .00 28. .71 C

ANISOU 30 CB ARG A 34 4836 3892 2180 -309 1261 ^■470 c

ATOM 31 CG ARG A 34 12.722 -5. .290 -41. .961 1. .00 28. .44 c

ANISOU 31 CG ARG A 34 4532 3493 2780 -118 387 ^■363 c

ATOM 32 CD ARG A 34 11.966 -6. .062 -43. .018 1. .00 31. .58 c

ANISOU 32 CD ARG A 34 4908 4034 3055 183 -728 -99 c

ATOM 33 NE ARG A 34 11.244 -7. .167 -42. .405 1. .00 34. .72 N

ANISOU 33 NE ARG A 34 6111 4294 2786 381 -28 454 N

ATOM 34 CZ ARG A 34 10.245 -7. .821 -42. .987 1. .00 43. .24 C

ANISOU 34 CZ ARG A 34 6705 5004 4719 472 -919 -17 C

ATOM 35 NH1 ARG A 34 9.838 -7. .476 -44. .202 1. .00 50. .22 N

ANISOU 35 NH1 ARG A 34 9045 5679 4357 129 -1192 ^■695 N

ATOM 36 NH2 ARG A 34 9.645 -8. .815 -42. .349 1. .00 46. .10 N

ANISOU 36 NH2 ARG A 34 6452 4940 6123 553 109 ^■529 N

ATOM 37 N LYS A 35 16.341 -3. .582 -41. .704 1. .00 26. .36 N

ANISOU 37 N LYS A 35 3923 3070 3021 275 562 ^■315 N

ATOM 38 CA LYS A 35 17.631 -4. .181 -41. .378 1. .00 27. .29 C

ANISOU 38 CA LYS A 35 3653 4076 2639 66 655 235 C

ATOM 39 C LYS A 35 18.288 -3. .469 -40. .197 1. .00 26. .48 C

ANISOU 39 C LYS A 35 3606 3211 3244 418 440 284 C

ATOM 40 O LYS A 35 19.125 -4. .047 -39. .503 1. .00 28. .57 O

ANISOU 40 O LYS A 35 3643 4054 3156 1038 336 173 O

ATOM 41 CB LYS A 35 18.553 -4. .160 -42. .605 1. .00 28. .18 C

ANISOU 41 CB LYS A 35 3030 4671 3006 342 753 164 C

ATOM 42 N ASN A 36 17.906 -2. .215 -39. .974 1. .00 27. .54 N

ANISOU 42 N ASN A 36 2885 3745 3833 1085 863 141 N

ATOM 43 CA ASN A 36 18.494 -1. .407 -38. .911 1. .00 27. .29 C

ANISOU 43 CA ASN A 36 3160 3505 3704 778 883 86 C

ATOM 44 C ASN A 36 17.410 -0. .630 -38. .147 1. .00 21. .55 C

ANISOU 44 C ASN A 36 2431 3101 2653 479 316 184 C

ATOM 45 O ASN A 36 17.339 0, .609 -38. .242 1. .00 20. .62 O

ANISOU 45 O ASN A 36 2098 3178 2557 508 433 230 O

ATOM 46 CB ASN A 36 19.544 -0. .458 -39. .506 1. .00 31. .06 C ANISOU 46 CB ASN A 36 2885 4318 4598 530 893 339 C

ATOM 47 CG ASN A 36 20.490 0. .112 -38. .458 1. .00 37. .00 C

ANISOU 47 CG ASN A 36 4243 4906 4907 345 489 282 C

ATOM 48 OD1 ASN A 36 20.675 -0. ,461 -37. .383 1. .00 48. .52 O

ANISOU 48 OD1 ASN A 36 6061 6884 5489 -214 11 1065 O

ATOM 49 ND2 ASN A 36 21.112 1. .241 -38. .779 1. .00 41. .89 N

ANISOU 49 ND2 ASN A 36 5600 4375 5940 970 2174 131 N

ATOM 50 N PRO A 37 16.544 -1. ,355 -37. .403 1. .00 21. .07 N

ANISOU 50 N PRO A 37 2451 3057 2498 623 -84 465 N

ATOM 51 CA PRO A 37 15.409 -0. ,654 -36. .798 1. .00 19. .42 C

ANISOU 51 CA PRO A 37 2443 3148 1786 323 106 348 C

ATOM 52 C PRO A 37 15.826 0. .237 -35. .646 1. .00 21. .13 C

ANISOU 52 C PRO A 37 2971 2750 2307 679 -63 184 C

ATOM 53 O PRO A 37 16.818 -0. ,045 -34. .970 1. .00 24. .36 O

ANISOU 53 O PRO A 37 2940 3611 2704 707 - 179 491 O

ATOM 54 CB PRO A 37 14.509 -1. ,793 -36. .293 1. .00 20. .11 C

ANISOU 54 CB PRO A 37 2618 2617 2404 530 52 485 C

ATOM 55 CG PRO A 37 15.433 -2. ,951 -36. .081 1. .00 19. .40 C

ANISOU 55 CG PRO A 37 2544 2822 2002 730 567 382 C

ATOM 56 CD PRO A 37 16.523 -2. ,807 -37. .113 1. .00 19. .36 C

ANISOU 56 CD PRO A 37 2293 3102 1959 407 350 557 C

ATOM 57 N ALA A 38 15.067 1. .302 -35. .432 1. .00 18. .00 N

ANISOU 57 N ALA A 38 2451 2594 1793 413 152 272 N

ATOM 58 CA ALA A 38 15.216 2. .154 -34. .250 1. .00 19. .66 C

ANISOU 58 CA ALA A 38 2796 2864 1808 222 359 128 C

ATOM 59 C ALA A 38 14.512 1. .533 -33. .024 1. .00 16. .68 C

ANISOU 59 C ALA A 38 2413 2283 1638 100 - 169 272 C

ATOM 60 O ALA A 38 13.672 0. .648 -33. .178 1. .00 19. .03 O

ANISOU 60 O ALA A 38 2435 2882 1912 -286 117 530 O

ATOM 61 CB ALA A 38 14.652 3. .525 -34. .557 1. .00 19. .01 C

ANISOU 61 CB ALA A 38 2788 2456 1977 -27 697 142 C

ATOM 62 N ARG A 39 14.843 1. .981 -31. .808 1. .00 14. .00 N

ANISOU 62 N ARG A 39 1427 2398 1494 339 72 317 N

ATOM 63 CA ARG A 39 14.097 1. .482 -30. .628 1. .00 13. .78 C

ANISOU 63 CA ARG A 39 1667 2238 1329 380 12 303 C

ATOM 64 C ARG A 39 12.608 1. .853 -30. .724 1. .00 13. .53 C

ANISOU 64 C ARG A 39 1526 1945 1669 -13 -50 405 C

ATOM 65 O ARG A 39 11.719 1. ,017 -30. .481 1. .00 13. .16 O

ANISOU 65 O ARG A 39 1400 1934 1663 37 -15 313 O

ATOM 66 CB ARG A 39 14.711 1. .987 -29. .320 1. .00 13. .43 C

ANISOU 66 CB ARG A 39 1453 2160 1487 -149 223 88 C

ATOM 67 CG ARG A 39 14.058 1. .438 -28. .046 1. .00 14. .96 c

ANISOU 67 CG ARG A 39 2053 2329 1302 -154 159 113 c

ATOM 68 CD ARG A 39 14.688 2. .081 -26. .815 1. .00 17. .30 c

ANISOU 68 CD ARG A 39 2170 2516 1886 -47 - 130 -236 c

ATOM 69 NE ARG A 39 14.373 3. .513 -26. .709 1. .00 16. .73 N

ANISOU 69 NE ARG A 39 2215 2306 1834 -274 - 305 213 N

ATOM 70 CZ ARG A 39 13.299 4. .008 -26. .097 1. .00 17. .48 C

ANISOU 70 CZ ARG A 39 2664 2149 1826 -19 -37 758 C

ATOM 71 NH1 ARG A 39 12.413 3. ,188 -25. .511 1. .00 16. .73 N

ANISOU 71 NH1 ARG A 39 2852 1615 1888 -320 -93 204 N

ATOM 72 NH2 ARG A 39 13.121 5. .328 -26. .047 1. .00 18. .39 N

ANISOU 72 NH2 ARG A 39 2966 2177 1843 2 - 436 371 N

ATOM 73 N ASN A 40 12.354 3. .110 -31. .054 1. .00 12. .61 N

ANISOU 73 N ASN A 40 1382 1742 1666 40 14 38 N

ATOM 74 CA ASN A 40 10.998 3. .611 -31. .310 1. .00 13. .69 C

ANISOU 74 CA ASN A 40 1472 2079 1651 211 152 395 C

ATOM 75 C ASN A 40 11.093 4. .907 -32. .095 1. .00 14. .21 C

ANISOU 75 C ASN A 40 1735 1927 1735 255 -29 300 C

ATOM 76 O ASN A 40 12.193 5. .358 -32. .425 1. .00 14. .95 O

ANISOU 76 O ASN A 40 1677 2286 1716 319 252 12 O ATOM 77 CB ASN A 40 10.157 3.,764 -30..015 1..00 12..53 C

ANISOU 77 CB ASN A 40 1649 1823 1289 75 -27 254 C

ATOM 78 CG ASN A 40 10.647 4. .877 -29. .084 1. .00 15. .80 C

ANISOU 78 CG ASN A 40 2116 2186 1701 -87 -221 91 C

ATOM 79 OD1 ASN A 40 11.526 5. .662 -29. .421 1. .00 16. .00 O

ANISOU 79 OD1 ASN A 40 2232 2166 1678 48 77 27 O

ATOM 80 ND2 ASN A 40 10.029 4. .963 -27. .900 1. .00 19. .23 N

ANISOU 80 ND2 ASN A 40 3130 2405 1770 -196 47 176 N

ATOM 81 N CYS A 41 9.953 5. .510 -32. .406 1. .00 13. .90 N

ANISOU 81 N CYS A 41 1505 1916 1859 223 166 199 N

ATOM 82 CA CYS A 41 9.956 6. .737 -33. .221 1. .00 12. .77 C

ANISOU 82 CA CYS A 41 1346 1370 2135 71 82 -86 C

ATOM 83 C CYS A 41 10.539 7. .954 -32. .502 1. .00 13. .08 C

ANISOU 83 C CYS A 41 1152 1835 1982 26 -118 ^■236 C

ATOM 84 O CYS A 41 11.116 8. .844 -33. .143 1. .00 15. .96 O

ANISOU 84 O CYS A 41 1694 2178 2190 -481 42 ^■296 O

ATOM 85 CB CYS A 41 8.541 7. .057 -33. .703 1. .00 13. .25 C

ANISOU 85 CB CYS A 41 1489 1301 2243 338 78 27 C

ATOM 86 SG CYS A 41 7.849 5. .770 -34. .760 1. .00 14. .34 S

ANISOU 86 SG CYS A 41 1778 1879 1792 -151 64 198 S

ATOM 87 N ARG A 42 10.355 8. .026 -31. .187 1. .00 13. .94 N

ANISOU 87 N ARG A 42 1646 1637 2012 -7 -162 ^■119 N

ATOM 88 CA ARG A 42 10.891 9. .154 -30. .425 1. .00 14. .82 C

ANISOU 88 CA ARG A 42 1725 2223 1682 -497 -184 ^■184 C

ATOM 89 C ARG A 42 12.420 9. .217 -30. .499 1. .00 16. .56 C

ANISOU 89 C ARG A 42 1744 2461 2085 -115 -292 -33 C

ATOM 90 O ARG A 42 12.985 10. .318 -30. .645 1. .00 19. .47 O

ANISOU 90 O ARG A 42 2355 2614 2428 -436 -360 -74 O

ATOM 91 CB ARG A 42 10.393 9. ,160 -28. .968 1. .00 13. .30 C

ANISOU 91 CB ARG A 42 1361 2006 1684 -249 -206 ^■134 C

ATOM 92 CG ARG A 42 10.786 10. .415 -28. .195 1. .00 13. .93 c

ANISOU 92 CG ARG A 42 1408 1956 1929 -246 -501 -34 c

ATOM 93 CD ARG A 42 10.093 11. .641 -28. .776 1. .00 17. .06 c

ANISOU 93 CD ARG A 42 2302 1680 2497 -183 -434 101 c

ATOM 94 NE ARG A 42 10.498 12. .926 -28. .211 1. .00 15. .00 N

ANISOU 94 NE ARG A 42 1975 1747 1975 -129 -508 228 N

ATOM 95 CZ ARG A 42 11.521 13. .662 -28. .650 1. .00 18. .36 C

ANISOU 95 CZ ARG A 42 2237 2510 2229 -534 -356 21 C

ATOM 96 NH1 ARG A 42 12.325 13. .205 -29. .616 1. .00 16. .49 N

ANISOU 96 NH1 ARG A 42 2180 2198 1886 -58 -641 254 N

ATOM 97 NH2 ARG A 42 11.756 14. .856 -28. .101 1. .00 21. .45 N

ANISOU 97 NH2 ARG A 42 3305 2429 2417 -146 -789 85 N

ATOM 98 N ASP A 43 13.076 8. .049 -30. .405 1. .00 17. .04 N

ANISOU 98 N ASP A 43 1838 2575 2058 11 -298 ^■132 N

ATOM 99 CA ASP A 43 14.537 7. .957 -30. .546 1. .00 18. .31 C

ANISOU 99 CA ASP A 43 1886 2690 2380 -41 -175 235 C

ATOM 100 C ASP A 43 14.953 8. .329 -31. .940 1. .00 17. .98 C

ANISOU 100 C ASP A 43 1970 2586 2274 -166 -288 103 C

ATOM 101 O ASP A 43 15.986 8. .978 -32. .140 1. .00 19. .88 O

ANISOU 101 O ASP A 43 1608 2696 3250 58 -404 421 O

ATOM 102 CB ASP A 43 15.036 6. .536 -30. .284 1. .00 18. .16 C

ANISOU 102 CB ASP A 43 1802 3175 1923 559 -150 290 C

ATOM 103 CG ASP A 43 15.124 6. .209 -28. .814 1. .00 20. .95 C

ANISOU 103 CG ASP A 43 2458 3446 2053 203 -331 560 C

ATOM 104 OD1 ASP A 43 14.503 6. .929 -27. .983 1. .00 18. .48 O

ANISOU 104 OD1 ASP A 43 2179 2334 2506 -239 -557 229 O

ATOM 105 OD2 ASP A 43 15.830 5. .227 -28. .493 1. .00 23. .55 O

ANISOU 105 OD2 ASP A 43 2262 3062 3621 -155 -758 567 O

ATOM 106 N LEU A 44 14.182 7. .853 -32. .917 1. .00 17. .65 N

ANISOU 106 N LEU A 44 1652 2663 2388 -339 -283 305 N

ATOM 107 CA LEU A 44 14.487 8. .147 -34. .311 1. .00 18. .56 C ANISOU 107 CA LEU A 44 1876 2788 2386 -210 113 36 C

ATOM 108 C LEU A 44 14.439 9. ,664 -34. .555 1. .00 17. .92 C

ANISOU 108 C LEU A 44 1746 2860 2201 -17 -56 278 C

ATOM 109 O LEU A 44 15.349 10. .220 -35. .191 1. .00 20. .90 O

ANISOU 109 O LEU A 44 2028 3183 2728 -236 75 432 O

ATOM 110 CB LEU A 44 13.563 7. .339 -35. .235 1. .00 19. .01 C

ANISOU 110 CB LEU A 44 1030 3583 2607 36 -237 246 C

ATOM 111 CG LEU A 44 13.893 7. .084 -36. .706 1. .00 22. .83 C

ANISOU 111 CG LEU A 44 1631 3941 3103 132 234 -38 C

ATOM 112 CD1 LEU A 44 15.251 6. .410 -36. .943 1. .00 21. .48 C

ANISOU 112 CD1 LEU A 44 2078 3122 2959 86 1421 336 C

ATOM 113 CD2 LEU A 44 12.762 6. .299 -37. .355 1. .00 23. .22 C

ANISOU 113 CD2 LEU A 44 2285 3344 3191 -40 56 -96 C

ATOM 114 N LYS A 45 13.421 10. .334 -34. .014 1. .00 15. .18 N

ANISOU 114 N LYS A 45 1604 1954 2210 -87 -283 177 N

ATOM 115 CA LYS A 45 13.296 11. .793 -34. .114 1. .00 17. .43 C

ANISOU 115 CA LYS A 45 1939 2025 2658 -212 -295 479 C

ATOM 116 C LYS A 45 14.486 12. .493 -33. .447 1. .00 19. .49 C

ANISOU 116 C LYS A 45 2101 2566 2739 -275 -483 499 C

ATOM 117 O LYS A 45 15.115 13. .385 -34. .048 1. .00 22. .71 O

ANISOU 117 O LYS A 45 2315 2971 3342 -685 -951 1046 O

ATOM 118 CB LYS A 45 11.951 12. .268 -33. .511 1. .00 17. .03 C

ANISOU 118 CB LYS A 45 2099 1947 2423 27 -383 450 C

ATOM 119 CG LYS A 45 11.755 13. ,783 -33. .414 1. .00 21. .20 C

ANISOU 119 CG LYS A 45 2798 2047 3208 446 -515 636 c

ATOM 120 CD LYS A 45 10.493 14. .141 -32. .621 1. .00 20. .95 c

ANISOU 120 CD LYS A 45 2312 2291 3355 -221 -670 426 c

ATOM 121 CE LYS A 45 10.383 15. .634 -32. .299 1. .00 21. .38 c

ANISOU 121 CE LYS A 45 2607 2142 3373 -119 -286 825 c

ATOM 122 NZ LYS A 45 10.429 16. .462 -33. .530 1. .00 22. .20 N

ANISOU 122 NZ LYS A 45 2866 2140 3429 -343 -87 767 N

ATOM 123 N PHE A 46 14.804 12. .071 -32. .223 1. .00 17. .91 N

ANISOU 123 N PHE A 46 1883 2168 2752 6 -641 344 N

ATOM 124 CA PHE A 46 15.901 12. .674 -31. .449 1. .00 21. .29 C

ANISOU 124 CA PHE A 46 2356 2914 2816 -569 -843 533 C

ATOM 125 C PHE A 46 17.247 12. ,555 -32. .181 1. .00 20. .23 C

ANISOU 125 C PHE A 46 2383 2546 2756 -904 -795 540 C

ATOM 126 O PHE A 46 17.999 13. .527 -32. .287 1. .00 23. .13 O

ANISOU 126 O PHE A 46 2378 2904 3506 -1045 -489 1012 O

ATOM 127 CB PHE A 46 16.005 12. .036 -30. .050 1. .00 19. .53 C

ANISOU 127 CB PHE A 46 2560 2434 2427 223 -258 13 C

ATOM 128 CG PHE A 46 16.484 12. .990 -28. .978 1. .00 21. .92 C

ANISOU 128 CG PHE A 46 2716 2691 2921 273 -544 -279 C

ATOM 129 CD1 PHE A 46 17.823 13. .379 -28. .903 1. .00 25. .12 C

ANISOU 129 CD1 PHE A 46 3222 3016 3306 -281 -749 -217 c

ATOM 130 CD2 PHE A 46 15.590 13. .501 -28. .043 1. .00 22. .74 c

ANISOU 130 CD2 PHE A 46 3440 2757 2441 528 -506 61 c

ATOM 131 CE1 PHE A 46 18.260 14. ,255 -27. .911 1. .00 26. .13 c

ANISOU 131 CE1 PHE A 46 3923 3095 2908 -194 -860 -5 c

ATOM 132 CE2 PHE A 46 16.012 14. .377 -27. .054 1. .00 23. .29 c

ANISOU 132 CE2 PHE A 46 3065 2890 2891 344 -1253 256 c

ATOM 133 CZ PHE A 46 17.353 14. .755 -26. .982 1. .00 25. .37 c

ANISOU 133 CZ PHE A 46 3158 3764 2715 -88 -853 603 c

ATOM 134 N CYS A 47 17.529 11. .365 -32. .700 1. .00 21. .30 N

ANISOU 134 N CYS A 47 2656 2811 2626 -381 -631 964 N

ATOM 135 CA CYS A 47 18.813 11. .057 -33. .311 1. .00 22. .42 C

ANISOU 135 CA CYS A 47 2339 3391 2789 -463 -577 1327 C

ATOM 136 C CYS A 47 18.909 11. .443 -34. .788 1. .00 24. .46 C

ANISOU 136 C CYS A 47 2235 4189 2867 -87 -194 1426 C

ATOM 137 O CYS A 47 19.995 11. .701 -35. .281 1. .00 28. .88 0

ANISOU 137 O CYS A 47 2366 5223 3382 -846 -242 1485 0 ATOM 138 CB CYS A 47 19.179 9..579 -33..093 1..00 22..91 C

ANISOU 138 CB CYS A 47 2252 3286 3165 -483 -60 904 C

ATOM 139 SG CYS A 47 20.371 9. .285 -31. .751 1. .00 28. .38 S

ANISOU 139 SG CYS A 47 2259 5084 3439 27 92 1423 S

ATOM 140 N HIS A 48 17.774 11. .500 -35. .482 1. .00 24. .61 N

ANISOU 140 N HIS A 48 2265 4541 2542 -470 - 121 990 N

ATOM 141 CA HIS A 48 17.749 11. .847 -36. .900 1. .00 25. .13 C

ANISOU 141 CA HIS A 48 2497 4342 2708 -153 - 372 1265 C

ATOM 142 C HIS A 48 16.657 12. .852 -37. .178 1. .00 25. .90 C

ANISOU 142 C HIS A 48 2660 3937 3243 -181 - 203 890 C

ATOM 143 O HIS A 48 15.628 12. .496 -37. .766 1. .00 24. .07 O

ANISOU 143 O HIS A 48 2353 3531 3262 -177 49 1350 O

ATOM 144 CB HIS A 48 17.506 10. .601 -37. .743 1. .00 23. .04 C

ANISOU 144 CB HIS A 48 2221 3683 2850 -93 - 151 1455 C

ATOM 145 CG HIS A 48 18.561 9. ,545 -37. .606 1. .00 29. .08 c

ANISOU 145 CG HIS A 48 2497 4125 4425 181 - 296 1382 c

ATOM 146 ND1 HIS A 48 19.694 9. .563 -38. .323 1. .00 32. .15 N

ANISOU 146 ND1 HIS A 48 2125 4071 6018 906 - 147 1303 N

ATOM 147 CD2 HIS A 48 18.613 8. .403 -36. .816 1. .00 29. .34 C

ANISOU 147 CD2 HIS A 48 2744 3548 4854 436 - 779 1045 C

ATOM 148 CE1 HIS A 48 20.450 8. .491 -37. .998 1. .00 36. .01 C

ANISOU 148 CE1 HIS A 48 3050 5118 5514 1548 - 699 1957 C

ATOM 149 NE2 HIS A 48 19.784 7. .781 -37. .078 1. .00 38. .01 N

ANISOU 149 NE2 HIS A 48 3049 5332 6058 851 138 1109 N

ATOM 150 N PRO A 49 16.868 14. .124 -36. .778 1. .00 26. .42 N

ANISOU 150 N PRO A 49 2650 3888 3498 -369 - 135 943 N

ATOM 151 CA PRO A 49 15.806 15. .134 -36. .866 1. .00 26. .83 C

ANISOU 151 CA PRO A 49 3173 3265 3754 -686 - 439 1025 C

ATOM 152 C PRO A 49 15.403 15. .481 -38. .305 1. .00 28. .04 C

ANISOU 152 C PRO A 49 3270 3669 3711 -814 - 385 1047 C

ATOM 153 O PRO A 49 14.406 16. .165 -38. .513 1. .00 31. .76 O

ANISOU 153 O PRO A 49 3698 4280 4088 -505 - 809 1164 O

ATOM 154 CB PRO A 49 16.406 16. .355 -36. .148 1. .00 26. .32 C

ANISOU 154 CB PRO A 49 2608 3860 3533 -1089 - 601 960 C

ATOM 155 CG PRO A 49 17.889 16. .140 -36. .164 1. .00 28. .97 C

ANISOU 155 CG PRO A 49 2842 3988 4178 -536 181 972 C

ATOM 156 CD PRO A 49 18.113 14. .660 -36. .187 1. .00 25. .95 C

ANISOU 156 CD PRO A 49 2691 3892 3273 -432 - 195 926 C

ATOM 157 N GLU A 50 16.163 14. .992 -39. .282 1. .00 26. .91 N

ANISOU 157 N GLU A 50 3074 3718 3431 -1440 - 623 880 N

ATOM 158 CA GLU A 50 15.892 15. .291 -40. .690 1. .00 28. .82 C

ANISOU 158 CA GLU A 50 2684 4732 3532 -709 - 755 867 C

ATOM 159 C GLU A 50 14.811 14. .374 -41. .273 1. .00 22. .58 C

ANISOU 159 C GLU A 50 2237 3460 2881 -639 - 264 1671 C

ATOM 160 O GLU A 50 14.258 14. .664 -42. .340 1. .00 22. .73 O

ANISOU 160 O GLU A 50 2344 3352 2940 -444 - 293 1955 O

ATOM 161 CB GLU A 50 17.179 15. .210 -41. .530 1. .00 31. .60 C

ANISOU 161 CB GLU A 50 3159 4713 4134 -1354 86 1887 C

ATOM 162 CG GLU A 50 17.623 13. ,798 -41. .929 1. .00 33. .72 c

ANISOU 162 CG GLU A 50 3207 5168 4435 -800 652 1797 c

ATOM 163 CD GLU A 50 18.266 12. .986 -40. .800 1. .00 38. .25 c

ANISOU 163 CD GLU A 50 4712 5110 4710 -332 - 485 1069 c

ATOM 164 OE1 GLU A 50 18.516 13. .529 -39. .698 1. .00 30. .74 0

ANISOU 164 OE1 GLU A 50 2795 4677 4205 -295 - 988 1951 0

ATOM 165 OE2 GLU A 50 18.530 11. .778 -41. .017 1. .00 38. .71 0

ANISOU 165 OE2 GLU A 50 3960 4826 5920 -379 57 1619 0

ATOM 166 N LEU A 51 14.514 13. .274 -40. .583 1. .00 20. .74 N

ANISOU 166 N LEU A 51 1966 2821 3094 -329 35 1284 N

ATOM 167 CA LEU A 51 13.564 12. .292 -41. .111 1. .00 18. .59 C

ANISOU 167 CA LEU A 51 2217 2560 2283 -11 -57 1178 C

ATOM 168 C LEU A 51 12.128 12. .809 -41. .012 1. .00 19. .71 C ANISOU 168 C LEU A 51 2231 2874 2383 97 -379 919 C

ATOM 169 O LEU A 51 11.739 13. .417 -40. .005 1. .00 20. .90 O

ANISOU 169 O LEU A 51 1764 3755 2422 -39 107 954 O

ATOM 170 CB LEU A 51 13.715 10. .927 -40. .402 1. .00 20. .18 C

ANISOU 170 CB LEU A 51 2508 2687 2473 92 290 1410 C

ATOM 171 CG LEU A 51 15.012 10. ,144 -40. .683 1. .00 20. .76 C

ANISOU 171 CG LEU A 51 2155 3133 2598 -26 -65 1167 C

ATOM 172 CD1 LEU A 51 15.066 8. .889 -39. .831 1. .00 20. .53 C

ANISOU 172 CD1 LEU A 51 1152 3035 3611 68 - 296 1343 C

ATOM 173 CD2 LEU A 51 15.138 9. .799 -42. .164 1. .00 20. .90 C

ANISOU 173 CD2 LEU A 51 2025 3026 2890 -192 -38 438 C

ATOM 174 N LYS A 52 11.359 12. .573 -42. .074 1. .00 17. .86 N

ANISOU 174 N LYS A 52 1608 2471 2706 16 - 376 1063 N

ATOM 175 CA LYS A 52 9.961 12. .996 -42. .137 1. .00 18. .94 C

ANISOU 175 CA LYS A 52 1758 2477 2961 283 -37 1127 C

ATOM 176 C LYS A 52 9.011 11. .901 -41. .698 1. .00 16. .22 C

ANISOU 176 C LYS A 52 1723 2279 2158 304 33 646 C

ATOM 177 O LYS A 52 9.359 10. .710 -41. .680 1. .00 16. .23 O

ANISOU 177 O LYS A 52 1921 2126 2118 150 52 663 O

ATOM 178 CB LYS A 52 9.620 13. .463 -43. .542 1. .00 21. .67 C

ANISOU 178 CB LYS A 52 2496 2755 2981 -338 -61 1316 C

ATOM 179 CG LYS A 52 10.509 14. .635 -43. .950 1. .00 24. .35 C

ANISOU 179 CG LYS A 52 2146 3511 3595 -866 - 146 1358 c

ATOM 180 CD LYS A 52 9.898 15. ,486 -45. .033 1. .00 25. .72 c

ANISOU 180 CD LYS A 52 1215 4742 3815 -568 - 570 1251 c

ATOM 181 CE LYS A 52 10.936 16. .396 -45. .654 1. .00 31. .11 c

ANISOU 181 CE LYS A 52 3944 3078 4796 -1902 -1582 1927 c

ATOM 182 NZ LYS A 52 11.571 17. .328 -44. .681 1. .00 36. .87 N

ANISOU 182 NZ LYS A 52 4617 3272 6119 -1180 -2471 1264 N

ATOM 183 N SER A 53 7.806 12. .311 -41. .334 1. .00 15. .50 N

ANISOU 183 N SER A 53 1412 2495 1979 -38 93 976 N

ATOM 184 CA SER A 53 6.786 11. .367 -40. .855 1. .00 15. .02 C

ANISOU 184 CA SER A 53 1924 1773 2008 -97 246 532 C

ATOM 185 C SER A 53 6.462 10. .310 -41. .900 1. .00 15. .70 C

ANISOU 185 C SER A 53 2089 1956 1920 165 61 467 C

ATOM 186 O SER A 53 6.347 10. ,615 -43. .097 1. .00 18. .31 O

ANISOU 186 O SER A 53 2484 2391 2081 161 -56 904 O

ATOM 187 CB SER A 53 5.516 12. .108 -40. .473 1. .00 16. .00 C

ANISOU 187 CB SER A 53 1908 2109 2061 63 175 320 C

ATOM 188 OG SER A 53 5.792 13. .056 -39. .474 1. .00 16. .61 O

ANISOU 188 OG SER A 53 1930 2143 2238 44 -52 224 O

ATOM 189 N GLY A 54 6.315 9. .070 -41. .446 1. .00 14. .50 N

ANISOU 189 N GLY A 54 1874 1950 1686 160 235 397 N

ATOM 190 CA GLY A 54 6.151 7. .960 -42. .378 1. .00 14. .97 C

ANISOU 190 CA GLY A 54 1865 1874 1947 426 - 274 404 C

ATOM 191 C GLY A 54 6.349 6. .597 -41. .759 1. .00 16. .09 C

ANISOU 191 C GLY A 54 2408 1847 1859 265 -66 397 C

ATOM 192 O GLY A 54 6.429 6. .459 -40. .533 1. .00 15. .73 O

ANISOU 192 O GLY A 54 2079 2074 1822 183 - 280 179 O

ATOM 193 N GLU A 55 6.403 5. .594 -42. .629 1. .00 16. .11 N

ANISOU 193 N GLU A 55 2324 1907 1890 338 -44 261 N

ATOM 194 CA GLU A 55 6.564 4. .219 -42. .230 1. .00 16. .28 C

ANISOU 194 CA GLU A 55 2229 2009 1947 262 - 258 389 C

ATOM 195 C GLU A 55 8.011 3. .920 -41. .890 1. .00 16. .15 C

ANISOU 195 C GLU A 55 2112 2417 1607 2 - 211 667 C

ATOM 196 O GLU A 55 8.905 4. .212 -42. .703 1. .00 16. .20 O

ANISOU 196 O GLU A 55 1994 2719 1443 405 - 162 558 O

ATOM 197 CB GLU A 55 6.118 3. .309 -43. .369 1. .00 16. .92 C

ANISOU 197 CB GLU A 55 2253 1950 2224 -46 47 144 C

ATOM 198 CG GLU A 55 6.110 1. .843 -42. .986 1. .00 21. .15 c

ANISOU 198 CG GLU A 55 2934 1852 3250 318 - 631 -24 c ATOM 199 CD GLU A 55 5.447 1..000 -44..045 1..00 27..66 C

ANISOU 199 CD GLU A 55 4310 3299 2898 -219 -702 -290 C

ATOM 200 OE1 GLU A 55 6.160 0. .551 -44. .969 1. .00 29. .45 O

ANISOU 200 OE1 GLU A 55 4126 3382 3681 538 -556 -412 O

ATOM 201 OE2 GLU A 55 4.218 0. .787 -43. .939 1. .00 28. .56 O

ANISOU 201 OE2 GLU A 55 4362 3198 3291 -651 -587 131 O

ATOM 202 N TYR A 56 8.230 3. .323 -40. .711 1. .00 14. .59 N

ANISOU 202 N TYR A 56 1968 2244 1328 56 -77 418 N

ATOM 203 CA TYR A 56 9.572 2. ,909 -40. .251 1. .00 14. .66 C

ANISOU 203 CA TYR A 56 2058 2049 1463 173 -166 418 C

ATOM 204 C TYR A 56 9.483 1. .591 -39. .513 1. .00 14. .94 C

ANISOU 204 C TYR A 56 1838 2057 1779 129 -171 473 C

ATOM 205 O TYR A 56 8.385 1. .159 -39. .137 1. .00 16. .95 O

ANISOU 205 O TYR A 56 1788 2483 2168 Ill -71 586 O

ATOM 206 CB TYR A 56 10.234 3. .964 -39. .334 1. .00 12. .61 C

ANISOU 206 CB TYR A 56 2022 1623 1145 247 161 546 C

ATOM 207 CG TYR A 56 10.528 5. .262 -40. .042 1. .00 15. .03 c

ANISOU 207 CG TYR A 56 2124 1650 1937 71 98 719 c

ATOM 208 CD1 TYR A 56 11.713 5. .437 -40. .767 1. .00 16. .80 c

ANISOU 208 CD1 TYR A 56 2206 2148 2029 -4 142 609 c

ATOM 209 CD2 TYR A 56 9.602 6. .311 -40. .022 1. .00 13. .69 c

ANISOU 209 CD2 TYR A 56 1984 1492 1724 -68 -93 356 c

ATOM 210 CE1 TYR A 56 11.976 6. .629 -41. .436 1. .00 17. .63 c

ANISOU 210 CE1 TYR A 56 2979 1814 1904 270 102 434 c

ATOM 211 CE2 TYR A 56 9.848 7. .500 -40. .698 1. .00 16. .40 c

ANISOU 211 CE2 TYR A 56 2391 1689 2148 247 246 700 c

ATOM 212 CZ TYR A 56 11.034 7. .659 -41. .403 1. .00 18. .67 c

ANISOU 212 CZ TYR A 56 2516 2117 2459 218 409 766 c

ATOM 213 OH TYR A 56 11.274 8. .856 -42. .064 1. .00 18. .87 0

ANISOU 213 OH TYR A 56 2703 2271 2195 340 249 891 0

ATOM 214 N TRP A 57 10.642 0. ,971 -39. .280 1. .00 14. .04 N

ANISOU 214 N TRP A 57 1782 2229 1323 178 -135 568 N

ATOM 215 CA TRP A 57 10.729 -0. ,262 -38. .503 1. .00 13. .86 C

ANISOU 215 CA TRP A 57 1835 1859 1569 108 -179 333 c

ATOM 216 C TRP A 57 11.352 0. .075 -37. .174 1. .00 14. .85 c

ANISOU 216 C TRP A 57 1663 2374 1604 100 -261 452 c

ATOM 217 O TRP A 57 12.406 0. .738 -37. .103 1. .00 15. .88 0

ANISOU 217 O TRP A 57 1663 2650 1720 -84 -28 426 0

ATOM 218 CB TRP A 57 11.560 -1. ,312 -39. .251 1. .00 16. .50 c

ANISOU 218 CB TRP A 57 2263 2363 1641 411 -179 113 c

ATOM 219 CG TRP A 57 10.851 -1. ,856 -40. .463 1. .00 18. .34 c

ANISOU 219 CG TRP A 57 2344 2478 2145 -42 -310 53 c

ATOM 220 CD1 TRP A 57 10.765 -1. ,273 -41. .735 1. .00 17. .62 c

ANISOU 220 CD1 TRP A 57 2166 2572 1954 -286 -466 -44 c

ATOM 221 CD2 TRP A 57 10.079 -3. ,096 -40. .555 1. .00 20. .03 c

ANISOU 221 CD2 TRP A 57 3083 2102 2424 -5 -342 185 c

ATOM 222 NE1 TRP A 57 10.008 -2. ,049 -42. .579 1. .00 21. .00 N

ANISOU 222 NE1 TRP A 57 3781 1959 2239 -558 -826 1 N

ATOM 223 CE2 TRP A 57 9.559 -3. ,156 -41. .933 1. .00 22. .50 C

ANISOU 223 CE2 TRP A 57 3425 2673 2451 -680 -297 288 c

ATOM 224 CE3 TRP A 57 9.761 -4. ,125 -39. .663 1. .00 19. .71 c

ANISOU 224 CE3 TRP A 57 2947 2285 2255 -289 -16 1 c

ATOM 225 CZ2 TRP A 57 8.788 -4. ,226 -42. .383 1. .00 24. .08 c

ANISOU 225 CZ2 TRP A 57 3799 2325 3023 -378 -694 5 c

ATOM 226 CZ3 TRP A 57 8.982 -5. ,192 -40. .127 1. .00 25. .45 c

ANISOU 226 CZ3 TRP A 57 3850 2989 2830 -586 -858 -196 c

ATOM 227 CH2 TRP A 57 8.503 -5. ,238 -41. .454 1. .00 25. .31 c

ANISOU 227 CH2 TRP A 57 4276 2796 2544 -517 -632 -30 c

ATOM 228 N VAL A 58 10.682 -0. ,337 -36. .104 1. .00 14. .38 N

ANISOU 228 N VAL A 58 2026 2157 1281 446 -279 263 N

ATOM 229 CA VAL A 58 11.191 -0. ,133 -34. .755 1. .00 12. .40 C ANISOU 229 CA VAL A 58 1843 1623 1243 332 - 184 243 C

ATOM 230 C VAL A 58 11.220 -1. .445 -34. .004 1. .00 12. .55 C

ANISOU 230 C VAL A 58 1701 1712 1352 397 16 355 C

ATOM 231 O VAL A 58 10.568 -2. .408 -34. .398 1. .00 17. .02 O

ANISOU 231 O VAL A 58 2342 2392 1731 93 - 259 229 O

ATOM 232 CB VAL A 58 10.396 0, .947 -33. .974 1. .00 12. .66 C

ANISOU 232 CB VAL A 58 1615 1703 1492 225 172 323 C

ATOM 233 CGI VAL A 58 10.455 2, .286 -34. .722 1. .00 14. .52 C

ANISOU 233 CGI VAL A 58 1963 2275 1279 382 -35 804 C

ATOM 234 CG2 VAL A 58 8.944 0, .510 -33. .736 1. .00 14. .53 C

ANISOU 234 CG2 VAL A 58 1490 2330 1698 290 250 300 C

ATOM 235 N ASP A 59 11.989 -1. .484 -32. .925 1. .00 13. .10 N

ANISOU 235 N ASP A 59 1854 1840 1281 484 0 376 N

ATOM 236 CA ASP A 59 12.226 -2. .714 -32. .205 1. .00 13. .30 C

ANISOU 236 CA ASP A 59 1528 1841 1681 774 117 439 C

ATOM 237 C ASP A 59 12.336 -2. .402 -30. .711 1. .00 15. .21 C

ANISOU 237 C ASP A 59 1599 2378 1803 744 23 262 C

ATOM 238 O ASP A 59 13.441 -2. .337 -30. .149 1. .00 15. .15 O

ANISOU 238 O ASP A 59 1814 2029 1913 646 - 214 423 O

ATOM 239 CB ASP A 59 13.507 -3. .378 -32. .725 1. .00 15. .54 C

ANISOU 239 CB ASP A 59 2071 2079 1753 1054 523 458 C

ATOM 240 CG ASP A 59 13.726 -4. .755 -32. .143 1. .00 16. .12 c

ANISOU 240 CG ASP A 59 2250 2162 1711 720 78 627 c

ATOM 241 OD1 ASP A 59 12.775 -5. .346 -31. .556 1. .00 16. .11 0

ANISOU 241 OD1 ASP A 59 2090 2282 1748 716 -79 705 0

ATOM 242 OD2 ASP A 59 14.857 -5. .266 -32. .265 1. .00 18. .66 0

ANISOU 242 OD2 ASP A 59 2495 2413 2179 900 418 489 0

ATOM 243 N PRO A 60 11.182 -2. .209 -30. .056 1. .00 14. .08 N

ANISOU 243 N PRO A 60 1540 2194 1612 680 -56 315 N

ATOM 244 CA PRO A 60 11.182 -1. .745 -28. .678 1. .00 14. .43 C

ANISOU 244 CA PRO A 60 1602 2280 1600 490 145 260 C

ATOM 245 C PRO A 60 11.978 -2. .646 -27. .726 1. .00 13. .99 C

ANISOU 245 C PRO A 60 1518 2036 1758 232 31 295 C

ATOM 246 O PRO A 60 12.601 -2. .139 -26. .798 1. .00 14. .55 O

ANISOU 246 O PRO A 60 1314 2408 1804 271 - 115 292 0

ATOM 247 CB PRO A 60 9.685 -1. .682 -28. .340 1. .00 14. .12 c

ANISOU 247 CB PRO A 60 1558 2193 1613 430 -22 227 c

ATOM 248 CG PRO A 60 9.044 -1. .345 -29. .651 1. .00 11. .78 c

ANISOU 248 CG PRO A 60 1388 1717 1370 405 186 75 c

ATOM 249 CD PRO A 60 9.826 -2. .153 -30. .656 1. .00 13. .86 c

ANISOU 249 CD PRO A 60 1369 2423 1473 587 127 -124 c

ATOM 250 N ASN A 61 12.001 -3. .955 -27. .987 1. .00 13. .32 N

ANISOU 250 N ASN A 61 1186 1942 1932 278 127 448 N

ATOM 251 CA ASN A 61 12.675 -4. .906 -27. .079 1. .00 13. .64 C

ANISOU 251 CA ASN A 61 1403 1898 1882 94 -82 427 C

ATOM 252 C ASN A 61 14.133 -5. .137 -27. .472 1. .00 13. .48 C

ANISOU 252 C ASN A 61 1741 1717 1663 461 179 269 C

ATOM 253 O ASN A 61 14.845 -5. .939 -26. .843 1. .00 13. .89 0

ANISOU 253 O ASN A 61 1802 1605 1870 326 - 121 268 0

ATOM 254 CB ASN A 61 11.900 -6. .221 -26. .962 1. .00 13. .89 c

ANISOU 254 CB ASN A 61 2009 1530 1739 248 195 144 c

ATOM 255 CG ASN A 61 11.982 -7. .074 -28. .212 1. .00 14. .43 c

ANISOU 255 CG ASN A 61 2160 1665 1656 386 - 115 103 c

ATOM 256 OD1 ASN A 61 12.764 -6. .799 -29. .123 1. .00 17. .06 0

ANISOU 256 OD1 ASN A 61 2327 2072 2083 397 -47 418 0

ATOM 257 ND2 ASN A 61 11.186 -8. .128 -28. .253 1. .00 15. .40 N

ANISOU 257 ND2 ASN A 61 1904 1900 2047 357 - 121 334 N

ATOM 258 N GLN A 62 14.566 -4. .404 -28. .503 1. .00 12. .88 N

ANISOU 258 N GLN A 62 1793 1914 1185 11 -32 7 N

ATOM 259 CA GLN A 62 15.979 -4. .380 -28. .927 1. .00 15. .36 C

ANISOU 259 CA GLN A 62 1761 2241 1831 292 -8 83 C ATOM 260 C GLN A 62 16.542 -5 790 -29.096 1 00 16.38 C

ANISOU 260 C GLN A 62 2006 2272 1943 407 94 332 C

ATOM 261 O GLN A 62 15.822 -6 668 -29.565 1 00 16.11 O

ANISOU 261 O GLN A 62 2117 2392 1611 426 113 230 O

ATOM 262 CB GLN A 62 16.818 -3 484 -27.986 1 00 16.69 C

ANISOU 262 CB GLN A 62 1568 2482 2290 81 38 66 C

ATOM 263 CG GLN A 62 16.364 -2 021 -27.994 1 00 19.53 C

ANISOU 263 CG GLN A 62 1547 2588 3285 190 55 372 C

ATOM 264 CD GLN A 62 16.872 -1 261 -29.205 1 00 24.80 C

ANISOU 264 CD GLN A 62 2568 2860 3993 336 -382 1070 C

ATOM 265 OE1 GLN A 62 16.176 -1 136 -30.216 1 00 28.10 O

ANISOU 265 OE1 GLN A 62 3355 3425 3895 559 -551 745 O

ATOM 266 NE2 GLN A 62 18.090 -0 768 -29.120 1 00 24.08 N

ANISOU 266 NE2 GLN A 62 2475 2680 3991 104 -329 1159 N

ATOM 267 N GLY A 63 17.803 -6 023 -28.723 1 00 17.25 N

ANISOU 267 N GLY A 63 1936 2267 2351 597 290 436 N

ATOM 268 CA GLY A 63 18.429 -7 330 -28.946 1 00 17.25 C

ANISOU 268 CA GLY A 63 1663 2351 2536 752 97 524 C

ATOM 269 C GLY A 63 18.335 -7 768 -30.401 1 00 18.15 C

ANISOU 269 C GLY A 63 1805 2574 2515 619 390 485 C

ATOM 270 O GLY A 63 18.593 -6 974 -31.303 1 00 18.53 O

ANISOU 270 O GLY A 63 1934 2171 2934 580 370 480 O

ATOM 271 N CYS A 64 17.947 -9 022 -30.629 1 00 19.84 N

ANISOU 271 N CYS A 64 2602 2578 2359 804 15 2 N

ATOM 272 CA CYS A 64 17.756 -9 565 -31.981 1 00 17.94 C

ANISOU 272 CA CYS A 64 2343 2373 2099 959 143 437 C

ATOM 273 C CYS A 64 16.741 -8 720 -32.771 1 00 19.57 C

ANISOU 273 C CYS A 64 2714 2658 2064 1002 200 882 C

ATOM 274 O CYS A 64 15.661 -8 374 -32.272 1 00 18.28 O

ANISOU 274 O CYS A 64 2943 2492 1510 967 125 167 O

ATOM 275 CB CYS A 64 17.323 -11 037 -31.893 1 00 19.85 C

ANISOU 275 CB CYS A 64 3124 2032 2384 1226 208 336 C

ATOM 276 SG CYS A 64 17.058 -11 907 -33.462 1 00 24.23 S

ANISOU 276 SG CYS A 64 3697 3030 2478 945 323 129 S

ATOM 277 N LYS A 65 17.110 -8 369 -33.993 1 00 20.70 N

ANISOU 277 N LYS A 65 2978 2668 2216 1279 786 700 N

ATOM 278 CA LYS A 65 16.318 -7 454 -34.833 1 00 21.00 C

ANISOU 278 CA LYS A 65 2993 2756 2229 1452 798 688 C

ATOM 279 C LYS A 65 15.136 -8 111 -35.550 1 00 22.88 C

ANISOU 279 C LYS A 65 3637 2736 2318 1584 561 451 C

ATOM 280 O LYS A 65 14.305 -7 416 -36.149 1 00 24.74 O

ANISOU 280 O LYS A 65 4041 3487 1871 1847 117 142 O

ATOM 281 CB LYS A 65 17.223 -6 797 -35.894 1 00 26.72 C

ANISOU 281 CB LYS A 65 3702 3380 3067 1060 1066 1220 C

ATOM 282 CG LYS A 65 18.237 -5 795 -35.355 1 00 32.01 C

ANISOU 282 CG LYS A 65 3787 4041 4334 1274 513 865 C

ATOM 283 N LEU A 66 15.054 -9 438 -35.499 1 00 21.82 N

ANISOU 283 N LEU A 66 4005 2762 1523 1449 455 206 N

ATOM 284 CA LEU A 66 14.113 -10 195 -36.344 1 00 25.95 C

ANISOU 284 CA LEU A 66 4583 2880 2395 1534 -291 128 C

ATOM 285 C LEU A 66 12.642 -9 963 -36.010 1 00 25.12 C

ANISOU 285 C LEU A 66 4700 2930 1912 1458 -394 -278 C

ATOM 286 O LEU A 66 11.762 -10 213 -36.844 1 00 28.41 O

ANISOU 286 O LEU A 66 5356 2822 2614 262 -566 -1080 O

ATOM 287 CB LEU A 66 14.430 -11 695 -36.302 1 00 28.21 C

ANISOU 287 CB LEU A 66 5334 3076 2306 2172 -200 -440 C

ATOM 288 CG LEU A 66 15.674 -12 153 -37.061 1 00 32.63 C

ANISOU 288 CG LEU A 66 5540 3978 2878 2898 -152 79 C

ATOM 289 CD1 LEU A 66 16.008 -13 586 -36.677 1 00 33.25 C

ANISOU 289 CD1 LEU A 66 5075 4055 3503 3018 -239 264 C

ATOM 290 CD2 LEU A 66 15.482 -12 018 -38.563 1 00 37.67 C ANISOU 290 CD2 LEU A 66 6541 5039 2730 2267 98 -235 C

ATOM 291 N ASP A 67 12.370 -9. .482 -34. .800 1. .00 21. .82 N

ANISOU 291 N ASP A 67 4221 2089 1979 1011 -328 -260 N

ATOM 292 CA ASP A 67 10.993 -9. .217 -34. .408 1. .00 20. .76 C

ANISOU 292 CA ASP A 67 3889 2155 1843 338 -251 -200 C

ATOM 293 C ASP A 67 10.632 -7. .727 -34. .464 1. .00 19. .89 C

ANISOU 293 C ASP A 67 3259 2142 2154 175 -569 374 C

ATOM 294 O ASP A 67 9.661 -7. .303 -33. .836 1. .00 20. .87 O

ANISOU 294 O ASP A 67 3683 2080 2166 248 -597 -167 O

ATOM 295 CB ASP A 67 10.691 -9. .824 -33. .026 1. .00 20. .64 C

ANISOU 295 CB ASP A 67 3468 2712 1659 401 -652 -93 C

ATOM 296 CG ASP A 67 11.571 -9. .255 -31. .914 1. .00 18. .94 C

ANISOU 296 CG ASP A 67 3330 2312 1554 Ill -316 -20 C

ATOM 297 OD1 ASP A 67 12.455 -8. .404 -32. .169 1. .00 17. .92 O

ANISOU 297 OD1 ASP A 67 3004 2093 1711 454 170 6 0

ATOM 298 OD2 ASP A 67 11.368 -9. .683 -30. .769 1. .00 17. .38 0

ANISOU 298 OD2 ASP A 67 2803 2422 1375 125 -368 -175 0

ATOM 299 N ALA A 68 11.412 -6. .936 -35. .209 1. .00 18. .53 N

ANISOU 299 N ALA A 68 3057 2072 1909 207 -572 124 N

ATOM 300 CA ALA A 68 11.070 -5. .526 -35. .415 1. .00 17. .69 C

ANISOU 300 CA ALA A 68 2566 1946 2208 74 -51 253 C

ATOM 301 C ALA A 68 9.672 -5. .399 -36. .037 1. .00 17. .70 C

ANISOU 301 C ALA A 68 3045 1634 2044 -14 -561 227 C

ATOM 302 O ALA A 68 9.223 -6. .287 -36. .768 1. .00 20. .36 O

ANISOU 302 O ALA A 68 3011 2544 2178 59 -1015 -215 O

ATOM 303 CB ALA A 68 12.121 -4. .807 -36. .265 1. .00 18. .67 c

ANISOU 303 CB ALA A 68 2374 2557 2162 387 0 509 c

ATOM 304 N ILE A 69 8.978 -4. .316 -35. .706 1. .00 16. .05 N

ANISOU 304 N ILE A 69 2183 2134 1779 17 -167 158 N

ATOM 305 CA ILE A 69 7.622 -4. .075 -36. .213 1. .00 18. .05 C

ANISOU 305 CA ILE A 69 2358 2414 2085 333 -123 406 C

ATOM 306 C ILE A 69 7.548 -2. .820 -37. .063 1. .00 16. .23 C

ANISOU 306 C ILE A 69 2298 2080 1786 404 -318 61 C

ATOM 307 O ILE A 69 8.298 -1. .862 -36. .861 1. .00 16. .64 O

ANISOU 307 O ILE A 69 2426 2270 1625 214 -227 406 O

ATOM 308 CB ILE A 69 6.587 -4. .001 -35. .061 1. .00 18. .98 c

ANISOU 308 CB ILE A 69 2743 2038 2428 86 230 398 c

ATOM 309 CGI ILE A 69 7.003 -2. .947 -34. .026 1. .00 17. .96 c

ANISOU 309 CGI ILE A 69 2363 2062 2399 117 457 406 c

ATOM 310 CG2 ILE A 69 6.381 -5. .382 -34. .431 1. .00 18. .64 c

ANISOU 310 CG2 ILE A 69 1978 2005 3099 -164 -228 509 c

ATOM 311 CD1 ILE A 69 5.893 -2. .566 -33. .078 1. .00 19. .28 c

ANISOU 311 CD1 ILE A 69 2650 2622 2052 40 586 357 c

ATOM 312 N LYS A 70 6.616 -2. .831 -38. .016 1. .00 17. .81 N

ANISOU 312 N LYS A 70 3130 2147 1489 153 -558 574 N

ATOM 313 CA LYS A 70 6.410 -1. .728 -38. .919 1. .00 15. .98 C

ANISOU 313 CA LYS A 70 2811 1980 1279 433 -713 324 C

ATOM 314 C LYS A 70 5.387 -0. .770 -38. .320 1. .00 14. .76 C

ANISOU 314 C LYS A 70 2438 1804 1365 -269 -417 30 C

ATOM 315 O LYS A 70 4.287 -1. .179 -37. .917 1. .00 17. .39 0

ANISOU 315 O LYS A 70 2100 2209 2296 -82 -551 577 0

ATOM 316 CB LYS A 70 5.901 -2. .282 -40. .246 1. .00 22. .98 c

ANISOU 316 CB LYS A 70 4541 2736 1452 105 -1298 344 c

ATOM 317 CG LYS A 70 6.140 -1. .383 -41. .443 1. .00 26. .57 c

ANISOU 317 CG LYS A 70 5416 3187 1491 -216 -1032 337 c

ATOM 318 CD LYS A 70 5.697 -2. .072 -42. .721 1. .00 31. .87 c

ANISOU 318 CD LYS A 70 6059 3821 2227 -1730 -1714 127 c

ATOM 319 CE LYS A 70 4.243 -2. .495 -42. .648 1. .00 34. .66 c

ANISOU 319 CE LYS A 70 7156 4286 1725 -3373 -1876 253 c

ATOM 320 NZ LYS A 70 3.794 -3. .084 -43. .931 1. .00 38. .21 N

ANISOU 320 NZ LYS A 70 7739 5172 1607 -3441 -1823 -597 N ATOM 321 N VAL A 71 5.741 0..505 -38..271 1..00 14..31 N

ANISOU 321 N VAL A 71 2413 1669 1353 -27 - 435 69 N

ATOM 322 CA VAL A 71 4.906 1. .494 -37. .562 1. .00 14. .22 C

ANISOU 322 CA VAL A 71 1887 1713 1803 -77 - 291 79 C

ATOM 323 C VAL A 71 4.818 2. .768 -38. .379 1. .00 14. .30 C

ANISOU 323 C VAL A 71 1839 2006 1587 -12 - 366 223 C

ATOM 324 O VAL A 71 5.543 2. .923 -39. .370 1. .00 15. .29 O

ANISOU 324 O VAL A 71 1782 2235 1793 201 - 291 560 O

ATOM 325 CB VAL A 71 5.459 1. .850 -36. .154 1. .00 13. .26 C

ANISOU 325 CB VAL A 71 1616 1747 1673 -385 - 156 387 C

ATOM 326 CGI VAL A 71 5.594 0. .623 -35. .262 1. .00 12. .74 C

ANISOU 326 CGI VAL A 71 1614 1881 1344 -127 - 205 345 C

ATOM 327 CG2 VAL A 71 6.789 2. .588 -36. .257 1. .00 14. .01 C

ANISOU 327 CG2 VAL A 71 1360 1875 2087 -275 - 200 43 C

ATOM 328 N PHE A 72 3.929 3. .676 -37. .980 1. .00 15. .33 N

ANISOU 328 N PHE A 72 1963 2025 1834 94 - 156 438 N

ATOM 329 CA PHE A 72 3.972 5. .045 -38. .498 1. .00 16. .21 C

ANISOU 329 CA PHE A 72 2077 1940 2141 325 - 190 294 C

ATOM 330 C PHE A 72 4.644 5. .903 -37. .437 1. .00 15. .10 C

ANISOU 330 C PHE A 72 1493 2214 2030 122 -73 400 C

ATOM 331 O PHE A 72 4.250 5. .867 -36. .282 1. .00 15. .09 O

ANISOU 331 O PHE A 72 1751 2295 1687 11 - 332 178 O

ATOM 332 CB PHE A 72 2.574 5. .600 -38. .826 1. .00 14. .61 C

ANISOU 332 CB PHE A 72 1893 1724 1934 196 - 109 325 C

ATOM 333 CG PHE A 72 2.580 7. .053 -39. .279 1. .00 14. .92 C

ANISOU 333 CG PHE A 72 1733 1834 2101 538 -53 454 c

ATOM 334 CD1 PHE A 72 2.886 7. ,391 -40. .602 1. .00 14. .29 c

ANISOU 334 CD1 PHE A 72 1211 2135 2084 592 - 239 571 c

ATOM 335 CD2 PHE A 72 2.288 8. .082 -38. .388 1. .00 14. .20 c

ANISOU 335 CD2 PHE A 72 1370 1628 2395 524 -86 427 c

ATOM 336 CE1 PHE A 72 2.877 8. .719 -41. .034 1. .00 14. .27 c

ANISOU 336 CE1 PHE A 72 1488 2039 1893 364 -3 339 c

ATOM 337 CE2 PHE A 72 2.277 9. .410 -38. .811 1. .00 14. .50 c

ANISOU 337 CE2 PHE A 72 1665 1833 2009 365 - 108 665 c

ATOM 338 CZ PHE A 72 2.578 9. .734 -40. .137 1. .00 13. .60 c

ANISOU 338 CZ PHE A 72 1504 1689 1973 504 8 517 c

ATOM 339 N CYS A 73 5.659 6. .660 -37. .845 1. .00 13. .33 N

ANISOU 339 N CYS A 73 1544 1989 1530 4 - 168 329 N

ATOM 340 CA CYS A 73 6.290 7. ,630 -36. .959 1. .00 15. .26 C

ANISOU 340 CA CYS A 73 1880 1779 2138 98 114 -67 C

ATOM 341 C CYS A 73 5.765 9. .018 -37. .282 1. .00 15. .97 c

ANISOU 341 C CYS A 73 1935 2007 2124 249 - 128 107 c

ATOM 342 O CYS A 73 5.931 9. .497 -38. .394 1. .00 15. .16 0

ANISOU 342 O CYS A 73 1622 2014 2122 -194 0 5 0

ATOM 343 CB CYS A 73 7.811 7. .638 -37. .135 1. .00 15. .40 c

ANISOU 343 CB CYS A 73 1869 1983 1999 -17 123 -16 c

ATOM 344 SG CYS A 73 8.676 6. .150 -36. .584 1. .00 15. .27 s

ANISOU 344 SG CYS A 73 1758 2172 1871 -134 126 251 s

ATOM 345 N ASN A 74 5.138 9. .666 -36. .310 1. .00 15. .01 N

ANISOU 345 N ASN A 74 1661 2079 1963 89 35 272 N

ATOM 346 CA ASN A 74 4.904 11. .098 -36. .421 1. .00 15. .84 C

ANISOU 346 CA ASN A 74 1639 2155 2226 439 30 96 C

ATOM 347 C ASN A 74 6.185 11. .822 -36. .013 1. .00 16. .04 C

ANISOU 347 C ASN A 74 2211 1743 2140 16 43 322 C

ATOM 348 O ASN A 74 6.529 11. .834 -34. .832 1. .00 17. .06 0

ANISOU 348 O ASN A 74 2064 2064 2354 -209 - 338 332 0

ATOM 349 CB ASN A 74 3.706 11. ,523 -35. .558 1. .00 15. .56 c

ANISOU 349 CB ASN A 74 1835 1954 2120 280 189 175 c

ATOM 350 CG ASN A 74 3.385 13. .004 -35. .705 1. .00 17. .08 c

ANISOU 350 CG ASN A 74 2010 1931 2549 315 78 111 c

ATOM 351 OD1 ASN A 74 4.280 13. .834 -35. .923 1. .00 17. .91 0 ANISOU 351 OD1 ASN A 74 2222 1880 2701 183 306 94 O

ATOM 352 ND2 ASN A 74 2.114 13. .340 -35. .610 1. .00 16. .52 N

ANISOU 352 ND2 ASN A 74 2009 2089 2177 336 375 91 N

ATOM 353 N MET A 75 6.908 12. .400 -36. .981 1. .00 14. .17 N

ANISOU 353 N MET A 75 911 1989 2484 189 35 261 N

ATOM 354 CA MET A 75 8.215 13. .021 -36. .666 1. .00 15. .04 C

ANISOU 354 CA MET A 75 1322 2375 2017 -196 41 81 C

ATOM 355 C MET A 75 8.164 14. .448 -36. .118 1. .00 16. .96 C

ANISOU 355 C MET A 75 1744 2330 2370 -26 -64 163 C

ATOM 356 O MET A 75 9.199 14. .993 -35. .701 1. .00 18. .30 O

ANISOU 356 O MET A 75 2135 2568 2250 -36 -473 175 O

ATOM 357 CB MET A 75 9.199 12. .873 -37. .838 1. .00 15. .16 C

ANISOU 357 CB MET A 75 964 2326 2467 -24 210 413 C

ATOM 358 CG MET A 75 9.574 11. .422 -38. .102 1. .00 16. .17 C

ANISOU 358 CG MET A 75 2059 2461 1622 165 129 222 C

ATOM 359 SD MET A 75 10.165 10. .562 -36. .624 1. .00 20. .22 S

ANISOU 359 SD MET A 75 2101 3132 2447 241 -220 809 S

ATOM 360 CE MET A 75 11.270 9. .385 -37. .363 1. .00 22. .52 C

ANISOU 360 CE MET A 75 2578 4168 1810 451 122 269 C

ATOM 361 N GLU A 76 6.964 15. ,038 -36. .092 1. .00 17. .04 N

ANISOU 361 N GLU A 76 2222 2025 2225 366 -508 173 N

ATOM 362 CA GLU A 76 6.738 16. .280 -35. .363 1. .00 18. .17 C

ANISOU 362 CA GLU A 76 2631 2358 1915 31 -62 -25 C

ATOM 363 C GLU A 76 6.625 16. .060 -33. .834 1. .00 18. .08 C

ANISOU 363 C GLU A 76 3343 1572 1953 -338 -625 323 C

ATOM 364 O GLU A 76 7.246 16. .772 -33. .045 1. .00 19. .68 O

ANISOU 364 O GLU A 76 2746 2304 2425 -556 -450 -93 O

ATOM 365 CB GLU A 76 5.516 17. .012 -35. .925 1. .00 21. .79 C

ANISOU 365 CB GLU A 76 3336 1874 3068 -250 -773 605 C

ATOM 366 CG GLU A 76 5.763 17. .535 -37. .334 1. .00 28. .60 c

ANISOU 366 CG GLU A 76 5333 2646 2885 -342 -551 158 c

ATOM 367 CD GLU A 76 6.960 18. .480 -37. .407 1. .00 37. .59 c

ANISOU 367 CD GLU A 76 6604 3444 4231 -1458 -554 -715 c

ATOM 368 OE1 GLU A 76 7.045 19. .406 -36. .567 1. .00 39. .59 0

ANISOU 368 OE1 GLU A 76 6387 3402 5254 -605 -1447 1130 0

ATOM 369 OE2 GLU A 76 7.819 18. .291 -38. .303 1. .00 45. .16 0

ANISOU 369 OE2 GLU A 76 6629 5839 4688 -2475 350 247 0

ATOM 370 N THR A 77 5.820 15. .086 -33. .430 1. .00 15. .78 N

ANISOU 370 N THR A 77 2850 1139 2005 207 -292 327 N

ATOM 371 CA THR A 77 5.668 14. .747 -32. .017 1. .00 18. .33 C

ANISOU 371 CA THR A 77 3124 1741 2097 22 -525 493 C

ATOM 372 C THR A 77 6.675 13. .686 -31. .544 1. .00 18. .39 C

ANISOU 372 C THR A 77 3015 1883 2090 61 -405 514 C

ATOM 373 O THR A 77 7.035 13. .669 -30. .379 1. .00 22. .34 0

ANISOU 373 O THR A 77 3770 2440 2276 -75 -824 517 0

ATOM 374 CB THR A 77 4.247 14. .240 -31. .735 1. .00 19. .46 c

ANISOU 374 CB THR A 77 3244 1853 2295 75 -221 626 c

ATOM 375 OG1 THR A 77 3.996 13. ,082 -32. .550 1. .00 17. .64 0

ANISOU 375 OG1 THR A 77 2447 1997 2256 120 -244 536 0

ATOM 376 CG2 THR A 77 3.197 15. .349 -32. .041 1. .00 22. .23 c

ANISOU 376 CG2 THR A 77 3309 2111 3023 245 -104 577 c

ATOM 377 N GLY A 78 7.130 12. .815 -32. .439 1. .00 16. .49 N

ANISOU 377 N GLY A 78 2240 1358 2667 -350 -547 282 N

ATOM 378 CA GLY A 78 7.928 11. .639 -32. .042 1. .00 15. .19 C

ANISOU 378 CA GLY A 78 1784 1535 2452 -437 -407 356 C

ATOM 379 C GLY A 78 7.075 10. .443 -31. .650 1. .00 14. .24 C

ANISOU 379 C GLY A 78 1754 1379 2277 -180 -216 420 C

ATOM 380 O GLY A 78 7.584 9. .461 -31. .126 1. .00 16. .31 0

ANISOU 380 O GLY A 78 1770 2115 2308 34 - 666 653 0

ATOM 381 N GLU A 79 5.772 10. .508 -31. .917 1. .00 14. .95 N

ANISOU 381 N GLU A 79 1797 1674 2210 147 -308 26 N ATOM 382 CA GLU A 79 4.865 9..399 -31..599 1..00 13..55 C

ANISOU 382 CA GLU A 79 1732 1575 1842 275 -137 125 C

ATOM 383 C GLU A 79 5.121 8. .165 -32. .463 1. .00 12. .45 C

ANISOU 383 C GLU A 79 1337 1522 1869 156 -175 157 C

ATOM 384 O GLU A 79 5.361 8. .285 -33. .664 1. .00 14. .90 O

ANISOU 384 O GLU A 79 1934 1940 1786 181 -216 -12 O

ATOM 385 CB GLU A 79 3.400 9. .825 -31. .770 1. .00 15. .56 C

ANISOU 385 CB GLU A 79 1824 1675 2411 393 -192 ^■117 C

ATOM 386 CG GLU A 79 2.852 10. .674 -30. .634 1. .00 16. .47 C

ANISOU 386 CG GLU A 79 2312 2226 1721 268 -170 54 C

ATOM 387 CD GLU A 79 1.568 11. .369 -31. .026 1. .00 17. .48 C

ANISOU 387 CD GLU A 79 2368 1804 2468 587 482 33 C

ATOM 388 OE1 GLU A 79 1.599 12. .174 -31. .986 1. .00 20. .60 O

ANISOU 388 OE1 GLU A 79 3149 2065 2612 154 -461 216 O

ATOM 389 OE2 GLU A 79 0.527 11. ,102 -30. .391 1. .00 20. .26 O

ANISOU 389 OE2 GLU A 79 2930 2626 2139 725 803 402 O

ATOM 390 N THR A 80 5.057 6. .995 -31. .836 1. .00 11. .15 N

ANISOU 390 N THR A 80 1060 1461 1713 78 -200 84 N

ATOM 391 CA THR A 80 5.100 5. .702 -32. .517 1. .00 12. .17 C

ANISOU 391 CA THR A 80 1463 1405 1756 -99 33 141 C

ATOM 392 C THR A 80 3.647 5. .207 -32. .599 1. .00 12. .85 C

ANISOU 392 C THR A 80 1378 1714 1790 38 -196 57 C

ATOM 393 O THR A 80 3.030 4. .930 -31. .553 1. .00 13. .45 O

ANISOU 393 O THR A 80 1346 1926 1838 90 -172 106 O

ATOM 394 CB THR A 80 5.925 4. .683 -31. .693 1. .00 12. .42 C

ANISOU 394 CB THR A 80 1617 1170 1931 4 76 33 C

ATOM 395 OG1 THR A 80 7.266 5. ,161 -31. .494 1. .00 13. .29 0

ANISOU 395 OG1 THR A 80 1607 1782 1657 -212 352 169 0

ATOM 396 CG2 THR A 80 5.964 3. .337 -32. .370 1. .00 12. .76 c

ANISOU 396 CG2 THR A 80 1971 1298 1578 305 568 -9 c

ATOM 397 N CYS A 81 3.107 5. .101 -33. .816 1. .00 11. .04 N

ANISOU 397 N CYS A 81 1011 1494 1686 -86 -68 -48 N

ATOM 398 CA CYS A 81 1.679 4. .774 -34. .011 1. .00 10. .39 C

ANISOU 398 CA CYS A 81 952 1244 1750 66 -6 53 C

ATOM 399 C CYS A 81 1.485 3. .428 -34. .684 1. .00 13. .04 C

ANISOU 399 C CYS A 81 1850 1351 1751 -187 -72 47 C

ATOM 400 O CYS A 81 2.052 3. .180 -35. .759 1. .00 16. .24 O

ANISOU 400 O CYS A 81 2510 2213 1448 22 -181 105 O

ATOM 401 CB CYS A 81 1.008 5. ,863 -34. .848 1. .00 12. .83 c

ANISOU 401 CB CYS A 81 1534 1830 1508 219 -161 256 c

ATOM 402 SG CYS A 81 1.036 7. .484 -34. .040 1. .00 18. .51 s

ANISOU 402 SG CYS A 81 2822 2148 2062 202 -538 -55 s

ATOM 403 N ILE A 82 0.699 2. .556 -34. .046 1. .00 11. .64 N

ANISOU 403 N ILE A 82 1117 1478 1826 -174 -257 -17 N

ATOM 404 CA ILE A 82 0.539 1. .166 -34. .500 1. .00 12. .37 C

ANISOU 404 CA ILE A 82 1361 1458 1879 -61 -382 -58 C

ATOM 405 C ILE A 82 -0.918 0. ,983 -34. .882 1. .00 14. .47 C

ANISOU 405 C ILE A 82 1367 2209 1921 42 -381 ^■177 C

ATOM 406 O ILE A 82 -1.800 1. ,279 -34. .075 1. .00 13. .93 O

ANISOU 406 O ILE A 82 1086 2166 2039 205 -455 ^■155 0

ATOM 407 CB ILE A 82 0.918 0. .155 -33. .384 1. .00 14. .13 c

ANISOU 407 CB ILE A 82 1624 1468 2275 178 -435 29 c

ATOM 408 CGI ILE A 82 2.402 0. .304 -33. .046 1. .00 17. .21 c

ANISOU 408 CGI ILE A 82 1896 2196 2448 -206 -816 207 c

ATOM 409 CG2 ILE A 82 0.669 -1. ,278 -33. .832 1. .00 15. .09 c

ANISOU 409 CG2 ILE A 82 1952 1307 2475 34 -458 367 c

ATOM 410 CD1 ILE A 82 2.892 -0. ,579 -31. .914 1. .00 21. .90 c

ANISOU 410 CD1 ILE A 82 2895 2664 2760 481 -679 416 c

ATOM 411 N SER A 83 -1.168 0. ,474 -36. .085 1. .00 14. .65 N

ANISOU 411 N SER A 83 1766 1968 1830 -41 -580 66 N

ATOM 412 CA SER A 83 -2.529 0. ,391 -36. .588 1. .00 14. .33 C ANISOU 412 CA SER A 83 1662 2009 1774 23 -415 -119 C

ATOM 413 C SER A 83 -3.218 -0 862 -36.114 1 00 16.72 C

ANISOU 413 C SER A 83 1769 2252 2332 124 -69 231 C

ATOM 414 O SER A 83 -2.558 -1 903 -35.908 1 00 16.87 O

ANISOU 414 O SER A 83 1567 2464 2377 271 -63 -2 O

ATOM 415 CB SER A 83 -2.533 0 394 -38.116 1 00 17.72 C

ANISOU 415 CB SER A 83 2243 2748 1740 -363 -527 -19 C

ATOM 416 OG SER A 83 -1.993 1 614 -38.610 1 00 21.30 O

ANISOU 416 OG SER A 83 2917 2964 2211 -571 -633 198 O

ATOM 417 N ALA A 84 -4.543 -0 765 -35.953 1 00 15.95 N

ANISOU 417 N ALA A 84 1750 2094 2215 52 121 -296 N

ATOM 418 CA ALA A 84 -5.378 -1 939 -35.749 1 00 17.01 C

ANISOU 418 CA ALA A 84 1916 2287 2259 -69 311 -129 C

ATOM 419 C ALA A 84 -5.445 -2 741 -37.028 1 00 17.31 C

ANISOU 419 C ALA A 84 1703 2401 2472 3 319 -282 C

ATOM 420 O ALA A 84 -5.343 -2 188 -38.122 1 00 17.59 O

ANISOU 420 O ALA A 84 1518 2584 2582 289 43 -116 O

ATOM 421 CB ALA A 84 -6.780 -1 541 -35.318 1 00 17.10 C

ANISOU 421 CB ALA A 84 1606 2614 2277 -480 61 -607 C

ATOM 422 N ASN A 85 -5.626 -4 048 -36.898 1 00 18.25 N

ANISOU 422 N ASN A 85 2391 2269 2273 139 526 -337 N

ATOM 423 CA ASN A 85 -5.767 -4 906 -38.070 1 00 21.50 C

ANISOU 423 CA ASN A 85 2587 2887 2696 201 76 -778 C

ATOM 424 C ASN A 85 -6.630 -6 115 -37.734 1 00 22.24 C

ANISOU 424 C ASN A 85 2689 2756 3003 253 -412 -429 C

ATOM 425 O ASN A 85 -6.176 -7 014 -37.021 1 00 29.70 O

ANISOU 425 O ASN A 85 3835 2920 4529 667 -152 164 O

ATOM 426 CB ASN A 85 -4.393 -5 333 -38.609 1 00 24.98 C

ANISOU 426 CB ASN A 85 2677 3504 3309 53 485 -614 C

ATOM 427 CG ASN A 85 -4.481 -6 001 -39.967 1 00 27.70 C

ANISOU 427 CG ASN A 85 2842 3988 3693 833 1044 -1148 C

ATOM 428 OD1 ASN A 85 -5.538 -6 480 -40.371 1 00 32.42 O

ANISOU 428 OD1 ASN A 85 4293 4264 3761 -27 344 -1633 O

ATOM 429 ND2 ASN A 85 -3.366 -6 048 -40.677 1 00 32.02 N

ANISOU 429 ND2 ASN A 85 3821 4574 3769 1015 1880 -686 N

ATOM 430 N PRO A 86 -7.888 -6 138 -38.221 1 00 24.52 N

ANISOU 430 N PRO A 86 2353 3356 3607 117 -208 -372 N

ATOM 431 CA PRO A 86 -8.524 -5 128 -39.085 1 00 22.92 C

ANISOU 431 CA PRO A 86 2279 3014 3414 66 -592 -733 C

ATOM 432 C PRO A 86 -8.806 -3 833 -38.351 1 00 21.17 C

ANISOU 432 C PRO A 86 2427 2997 2619 -353 -569 -704 C

ATOM 433 O PRO A 86 -9.025 -3 846 -37.150 1 00 23.40 O

ANISOU 433 O PRO A 86 2729 3493 2668 770 -656 -916 O

ATOM 434 CB PRO A 86 -9.868 -5 765 -39.482 1 00 24.93 C

ANISOU 434 CB PRO A 86 2198 3479 3794 -242 -369 -476 C

ATOM 435 CG PRO A 86 -10.027 -6 986 -38.658 1 00 24.80 C

ANISOU 435 CG PRO A 86 929 3782 4710 -48 -89 22 C

ATOM 436 CD PRO A 86 -8.808 -7 217 -37.824 1 00 26.20 C

ANISOU 436 CD PRO A 86 2540 3288 4124 -98 -955 -68 C

ATOM 437 N LEU A 87 -8.828 -2 723 -39.073 1 00 20.92 N

ANISOU 437 N LEU A 87 2026 3243 2677 170 -673 -598 N

ATOM 438 CA LEU A 87 -9.087 -1 442 -38.429 1 00 25.13 C

ANISOU 438 CA LEU A 87 2906 3341 3299 496 -209 -508 C

ATOM 439 C LEU A 87 -10.539 -1 026 -38.561 1 00 21.52 C

ANISOU 439 C LEU A 87 2442 3258 2476 -102 -68 -564 C

ATOM 440 O LEU A 87 -10.965 -0 039 -37.963 1 00 25.20 O

ANISOU 440 O LEU A 87 3224 3361 2988 317 -1181 -1101 O

ATOM 441 CB LEU A 87 -8.164 -0 353 -38.971 1 00 29.90 C

ANISOU 441 CB LEU A 87 3707 4252 3401 255 491 43 C

ATOM 442 CG LEU A 87 -7.979 -0 224 -40.483 1 00 30.06 C

ANISOU 442 CG LEU A 87 4170 3758 3493 -91 647 1706 C ATOM 443 CD1 LEU A 87 -9.136 0 515 -41.137 1 00 34.66 C

ANISOU 443 CD1 LEU A 87 5190 3299 4677 249 -202 1380 C

ATOM 444 CD2 LEU A 87 -6.673 0 502 -40.744 1 00 35.37 C

ANISOU 444 CD2 LEU A 87 4357 3858 5220 -238 1285 1311 C

ATOM 445 N ASN A 88 -11.293 -1 789 -39.342 1 00 19.61 N

ANISOU 445 N ASN A 88 1845 3363 2242 283 -393 -289 N

ATOM 446 CA ASN A 88 -12.675 -1 446 -39.639 1 00 19.53 C

ANISOU 446 CA ASN A 88 1649 3410 2360 81 -354 -672 C

ATOM 447 C ASN A 88 -13.668 -2 497 -39.139 1 00 21.42 C

ANISOU 447 C ASN A 88 2063 3226 2847 179 126 -816 C

ATOM 448 O ASN A 88 -13.459 -3 691 -39.343 1 00 23.02 O

ANISOU 448 O ASN A 88 1931 3407 3407 642 -588 -828 O

ATOM 449 CB ASN A 88 -12.819 -1 262 -41.155 1 00 25.87 C

ANISOU 449 CB ASN A 88 2684 4571 2574 182 -893 -244 C

ATOM 450 CG ASN A 88 -14.230 -0 927 -41.569 1 00 28.54 C

ANISOU 450 CG ASN A 88 2456 5268 3117 94 -593 -68 C

ATOM 451 OD1 ASN A 88 -14.751 0 138 -41.238 1 00 35.43 O

ANISOU 451 OD1 ASN A 88 5201 4706 3553 -209 -994 -33 O

ATOM 452 ND2 ASN A 88 -14.865 -1 835 -42.296 1 00 36.80 N

ANISOU 452 ND2 ASN A 88 5628 4880 3475 -54 -576 -569 N

ATOM 453 N VAL A 89 -14.737 -2 046 -38.476 1 00 19.01 N

ANISOU 453 N VAL A 89 1593 2497 3130 -419 88 -976 N

ATOM 454 CA VAL A 89 -15.925 -2 875 -38.244 1 00 17.78 C

ANISOU 454 CA VAL A 89 1711 2475 2570 -349 402 -919 C

ATOM 455 C VAL A 89 -16.955 -2 357 -39.244 1 00 18.90 C

ANISOU 455 C VAL A 89 1990 2378 2812 -241 216 -992 C

ATOM 456 O VAL A 89 -17.359 -1 201 -39.145 1 00 21.19 O

ANISOU 456 O VAL A 89 2291 2498 3262 83 -22 -782 O

ATOM 457 CB VAL A 89 -16.467 -2 738 -36.791 1 00 16.33 C

ANISOU 457 CB VAL A 89 1759 2287 2157 -544 -44 -790 C

ATOM 458 CGI VAL A 89 -17.745 -3 547 -36.582 1 00 20.57 C

ANISOU 458 CGI VAL A 89 2016 2684 3116 -733 344 -839 C

ATOM 459 CG2 VAL A 89 -15.409 -3 139 -35.766 1 00 19.91 C

ANISOU 459 CG2 VAL A 89 2167 2564 2833 -305 -460 -705 C

ATOM 460 N PRO A 90 -17.377 -3 198 -40.214 1 00 21.62 N

ANISOU 460 N PRO A 90 2671 2936 2605 104 -117 -1178 N

ATOM 461 CA PRO A 90 -18.327 -2 776 -41.254 1 00 20.26 C

ANISOU 461 CA PRO A 90 2613 2352 2732 35 -334 -1324 C

ATOM 462 C PRO A 90 -19.644 -2 290 -40.670 1 00 20.77 C

ANISOU 462 C PRO A 90 2556 2529 2806 246 -594 -1259 C

ATOM 463 O PRO A 90 -20.049 -2 758 -39.594 1 00 20.29 O

ANISOU 463 O PRO A 90 1949 2817 2942 415 -723 -1169 O

ATOM 464 CB PRO A 90 -18.558 -4 068 -42.055 1 00 23.86 C

ANISOU 464 CB PRO A 90 3608 2911 2546 -71 -655 -1659 C

ATOM 465 CG PRO A 90 -17.283 -4 825 -41.894 1 00 26.39 C

ANISOU 465 CG PRO A 90 3704 3542 2781 -77 -490 -1370 C

ATOM 466 CD PRO A 90 -16.890 -4 575 -40.460 1 00 22.90 C

ANISOU 466 CD PRO A 90 3009 2823 2868 -56 -441 -1640 C

ATOM 467 N ARG A 91 -20.300 -1 366 -41.375 1 00 21.33 N

ANISOU 467 N ARG A 91 2764 2052 3289 337 -932 -1511 N

ATOM 468 CA ARG A 91 -21.609 -0 847 -40.959 1 00 22.58 C

ANISOU 468 CA ARG A 91 3012 2316 3250 224 -436 -1168 C

ATOM 469 C ARG A 91 -22.654 -1 937 -41.157 1 00 24.62 C

ANISOU 469 C ARG A 91 2784 3475 3095 -231 -593 -1420 C

ATOM 470 O ARG A 91 -22.832 -2 443 -42.266 1 00 27.71 O

ANISOU 470 O ARG A 91 3641 4132 2754 269 -333 -1376 O

ATOM 471 CB ARG A 91 -21.988 0 380 -41.783 1 00 22.37 C

ANISOU 471 CB ARG A 91 2511 3010 2976 495 -647 -852 C

ATOM 472 CG ARG A 91 -21.130 1 605 -41.535 1 00 23.29 C

ANISOU 472 CG ARG A 91 3187 2781 2879 258 -663 -297 C

ATOM 473 CD ARG A 91 -21.490 2 698 -42.523 1 00 33.04 C ANISOU 473 CD ARG A 91 4728 3346 4479 390 -699 730 C

ATOM 474 NE ARG A 91 -20.389 3. .640 -42. .658 1. .00 40. .56 N

ANISOU 474 NE ARG A 91 5488 4881 5041 -382 -754 1450 N

ATOM 475 CZ ARG A 91 -20.503 4. .900 -43. .075 1. .00 44. .21 C

ANISOU 475 CZ ARG A 91 5781 5310 5704 236 -433 1861 C

ATOM 476 NH1 ARG A 91 -21.687 5. .417 -43. .413 1. .00 46. .38 N

ANISOU 476 NH1 ARG A 91 5764 7904 3954 1133 -302 2176 N

ATOM 477 NH2 ARG A 91 -19.417 5. .655 -43. .148 1. .00 54. .55 N

ANISOU 477 NH2 ARG A 91 7178 6715 6832 -1414 -148 691 N

ATOM 478 N LYS A 92 -23.327 -2. .309 -40. .075 1. .00 26. .35 N

ANISOU 478 N LYS A 92 3407 3091 3512 -125 -117 - 1694 N

ATOM 479 CA LYS A 92 -24.289 -3. .408 -40. .085 1. .00 26. .81 C

ANISOU 479 CA LYS A 92 3152 3095 3939 -44 -354 - 1983 C

ATOM 480 C LYS A 92 -25.282 -3. .233 -38. .945 1. .00 26. .75 C

ANISOU 480 C LYS A 92 2716 3161 4285 -1133 -289 - 1261 C

ATOM 481 O LYS A 92 -25.023 -2. .504 -37. .974 1. .00 22. .39 O

ANISOU 481 O LYS A 92 2056 2812 3638 -325 50 - 1084 O

ATOM 482 CB LYS A 92 -23.526 -4. .738 -39. .922 1. .00 29. .80 C

ANISOU 482 CB LYS A 92 3616 3322 4382 -59 -793 - 1226 C

ATOM 483 CG LYS A 92 -24.267 -5. .999 -40. .304 1. .00 36. .00 C

ANISOU 483 CG LYS A 92 4790 3587 5301 -598 -362 - 1195 C

ATOM 484 CD LYS A 92 -23.294 -7. .054 -40. .799 1. .00 35. .56 C

ANISOU 484 CD LYS A 92 4449 4566 4493 422 -672 -489 C

ATOM 485 CE LYS A 92 -22.604 -7. .784 -39. .668 1. .00 33. .03 C

ANISOU 485 CE LYS A 92 2576 5428 4544 -681 -1394 -701 C

ATOM 486 NZ LYS A 92 -23.472 -8. .837 -39. .073 1. .00 41. .28 N

ANISOU 486 NZ LYS A 92 3989 5657 6036 -820 -953 -188 N

ATOM 487 N HIS A 93 -26.438 -3. .870 -39. .090 1. .00 29. .95 N

ANISOU 487 N HIS A 93 2674 3797 4905 -1266 -741 -664 N

ATOM 488 CA HIS A 93 -27.239 -4. .229 -37. .938 1. .00 30. .92 C

ANISOU 488 CA HIS A 93 2735 4277 4734 -1416 -922 -817 C

ATOM 489 C HIS A 93 -26.561 -5. .432 -37. .323 1. .00 31. .24 C

ANISOU 489 C HIS A 93 3310 4493 4066 -1595 -1075 -261 C

ATOM 490 O HIS A 93 -26.602 -6. .540 -37. .884 1. .00 37. .91 O

ANISOU 490 O HIS A 93 4602 4770 5033 -1050 -1261 -752 O

ATOM 491 CB HIS A 93 -28.667 -4. .567 -38. .352 1. .00 30. .17 C

ANISOU 491 CB HIS A 93 2544 3816 5104 -1899 -224 -930 C

ATOM 492 CG HIS A 93 -29.562 -4. .878 -37. .192 1. .00 32. .82 C

ANISOU 492 CG HIS A 93 2227 4686 5554 -1894 41 - 1174 C

ATOM 493 ND1 HIS A 93 -30.102 -3. .917 -36. .421 1. .00 35. .79 N

ANISOU 493 ND1 HIS A 93 3581 4967 5050 -1549 1070 -715 N

ATOM 494 CD2 HIS A 93 -29.989 -6. .096 -36. .665 1. .00 35. .29 C

ANISOU 494 CD2 HIS A 93 2848 5066 5495 -1168 186 -183 C

ATOM 495 CE1 HIS A 93 -30.856 -4. .488 -35. .456 1. .00 33. .83 C

ANISOU 495 CE1 HIS A 93 2743 4760 5348 -2301 617 -665 C

ATOM 496 NE2 HIS A 93 -30.783 -5. .820 -35. .607 1. .00 40. .53 N

ANISOU 496 NE2 HIS A 93 4419 5093 5884 -1547 1192 0 N

ATOM 497 N TRP A 94 -25.922 -5. .213 -36. .174 1. .00 25. .58 N

ANISOU 497 N TRP A 94 2001 3458 4260 -1430 -972 -57 N

ATOM 498 CA TRP A 94 -25.070 -6. .207 -35. .508 1. .00 23. .11 C

ANISOU 498 CA TRP A 94 2434 2892 3454 -1199 -582 -199 C

ATOM 499 C TRP A 94 -25.747 -6. .961 -34. .407 1. .00 22. .70 C

ANISOU 499 C TRP A 94 2204 2586 3835 -1266 -539 -180 C

ATOM 500 O TRP A 94 -25.372 -8. .100 -34. .109 1. .00 27. .24 O

ANISOU 500 O TRP A 94 2721 2562 5068 -656 0 -318 O

ATOM 501 CB TRP A 94 -23.870 -5. .502 -34. .892 1. .00 19. .99 C

ANISOU 501 CB TRP A 94 2178 2865 2551 -863 -322 -476 C

ATOM 502 CG TRP A 94 -22.780 -5. .168 -35. .880 1. .00 21. .41 C

ANISOU 502 CG TRP A 94 2285 2966 2883 -668 -127 -13 C

ATOM 503 CD1 TRP A 94 -22.523 -3. .944 -36. .485 1. .00 19. .93 C

ANISOU 503 CD1 TRP A 94 2088 2421 3063 -669 -355 -512 C ATOM 504 CD2 TRP A 94 -21.764 -6 084 -36.421 1.00 20.89 C

ANISOU 504 CD2 TRP A 94 2395 2677 2864 -460 -696 -128 C

ATOM 505 NE1 TRP A 94 -21.443 -4 041 -37.340 1.00 19.30 N

ANISOU 505 NE1 TRP A 94 1489 2777 3065 -265 -662 -181 N

ATOM 506 CE2 TRP A 94 -20.950 -5 297 -37.349 1.00 19.76 C

ANISOU 506 CE2 TRP A 94 2388 2553 2565 -381 -349 -632 C

ATOM 507 CE3 TRP A 94 -21.469 -7 434 -36.242 1.00 24.30 C

ANISOU 507 CE3 TRP A 94 2972 2883 3378 128 -953 -264 C

ATOM 508 CZ2 TRP A 94 -19.874 -5 853 -38.040 1.00 20.87 C

ANISOU 508 CZ2 TRP A 94 2110 2750 3067 -176 -438 -376 C

ATOM 509 CZ3 TRP A 94 -20.385 -7 981 -36.943 1.00 24.20 C

ANISOU 509 CZ3 TRP A 94 2849 2958 3386 -443 -650 -458 C

ATOM 510 CH2 TRP A 94 -19.613 -7 208 -37.823 1.00 20.15 C

ANISOU 510 CH2 TRP A 94 1957 2795 2901 -106 -880 -594 C

ATOM 511 N TRP A 95 -26.739 -6 326 -33.781 1.00 22.38 N

ANISOU 511 N TRP A 95 2650 2860 2992 -954 -521 -99 N

ATOM 512 CA TRP A 95 -27.345 -6 821 -32.544 1.00 23.57 C

ANISOU 512 CA TRP A 95 1583 3523 3846 -1129 -126 77 C

ATOM 513 C TRP A 95 -28.830 -6 699 -32.623 1.00 24.28 C

ANISOU 513 C TRP A 95 1610 3894 3719 -695 -62 -537 C

ATOM 514 O TRP A 95 -29.342 -5 680 -33.087 1.00 27.88 O

ANISOU 514 O TRP A 95 2808 4132 3650 -1205 -570 119 O

ATOM 515 CB TRP A 95 -26.840 -5 992 -31.364 1.00 26.20 C

ANISOU 515 CB TRP A 95 2648 3555 3750 -1021 -332 56 C

ATOM 516 CG TRP A 95 -27.330 -6 453 -30.008 1.00 25.98 C

ANISOU 516 CG TRP A 95 2517 3466 3888 -1216 -412 21 C

ATOM 517 CD1 TRP A 95 -28.261 -5 826 -29.181 1.00 25.12 C

ANISOU 517 CD1 TRP A 95 2429 3426 3689 -1252 -472 306 C

ATOM 518 CD2 TRP A 95 -26.915 -7 656 -29.272 1.00 25.80 C

ANISOU 518 CD2 TRP A 95 2308 3638 3854 -1108 -932 -40 C

ATOM 519 NE1 TRP A 95 -28.446 -6 539 -28.022 1.00 29.10 N

ANISOU 519 NE1 TRP A 95 3414 3986 3654 -751 -809 613 N

ATOM 520 CE2 TRP A 95 -27.674 -7 650 -28.014 1.00 30.12 C

ANISOU 520 CE2 TRP A 95 3289 3977 4175 -848 -509 75 C

ATOM 521 CE3 TRP A 95 -26.035 -8 706 -29.526 1.00 25.81 C

ANISOU 521 CE3 TRP A 95 2932 2706 4166 -1171 -1139 -242 C

ATOM 522 CZ2 TRP A 95 -27.529 -8 654 -27.060 1.00 28.01 C

ANISOU 522 CZ2 TRP A 95 2842 3272 4525 -1372 -154 28 C

ATOM 523 CZ3 TRP A 95 -25.901 -9 711 -28.559 1.00 30.19 C

ANISOU 523 CZ3 TRP A 95 3975 3427 4067 -969 -697 -32 C

ATOM 524 CH2 TRP A 95 -26.632 -9 684 -27.356 1.00 33.56 C

ANISOU 524 CH2 TRP A 95 3780 3931 5037 -656 -113 417 C

ATOM 525 N THR A 96 -29.539 -7 721 -32.158 1.00 26.11 N

ANISOU 525 N THR A 96 2484 3636 3799 -1023 -213 -767 N

ATOM 526 CA THR A 96 -31.009 -7 686 -32.159 1.00 30.42 C

ANISOU 526 CA THR A 96 2412 4444 4701 -1805 82 -899 C

ATOM 527 C THR A 96 -31.537 -7 980 -30.763 1.00 35.87 C

ANISOU 527 C THR A 96 3550 5790 4287 -863 -348 -359 C

ATOM 528 O THR A 96 -31.096 -8 939 -30.131 1.00 42.19 O

ANISOU 528 O THR A 96 4082 5698 6250 -731 -491 231 O

ATOM 529 CB THR A 96 -31.598 -8 719 -33.148 1.00 34.52 C

ANISOU 529 CB THR A 96 3782 5013 4322 -1107 -405 -1394 C

ATOM 530 OG1 THR A 96 -31.000 -8 548 -34.437 1.00 34.44 O

ANISOU 530 OG1 THR A 96 3940 3928 5217 -1883 647 -1504 O

ATOM 531 CG2 THR A 96 -33.127 -8 577 -33.272 1.00 36.17 C

ANISOU 531 CG2 THR A 96 3434 4578 5731 -1968 132 -1357 C

ATOM 532 N ASP A 97 -32.420 -7 124 -30.289 1.00 34.46 N

ANISOU 532 N ASP A 97 1867 6733 4492 -645 -1511 -243 N

ATOM 533 CA ASP A 97 -32.985 -7 356 -28.995 1.00 44.55 C

ANISOU 533 CA ASP A 97 5434 7472 4019 670 -522 -1326 C

ATOM 534 C ASP A 97 -34.289 -6 617 -28.782 1.00 48.94 C ANISOU 534 C ASP A 97 6061 8111 4421 1821 -609 -294 C

ATOM 535 O ASP A 97 -34.543 -5 607 -29.404 1 00 55.28 O

ANISOU 535 O ASP A 97 7782 8461 4759 1828 -848 408 O

ATOM 536 CB ASP A 97 -31.970 -7 003 -27.914 1 00 44.79 C

ANISOU 536 CB ASP A 97 4387 7590 5039 338 -1221 -459 C

ATOM 537 N LYS A 102 -32.750 -1 991 -23.196 1 00 38.41 N

ANISOU 537 N LYS A 102 692 9605 4294 658 267 -840 N

ATOM 538 CA LYS A 102 -31.426 -1 598 -23.697 1 00 32.79 C

ANISOU 538 CA LYS A 102 908 6911 4637 1628 929 -517 C

ATOM 539 C LYS A 102 -30.316 -1 742 -22.640 1 00 33.85 C

ANISOU 539 C LYS A 102 2680 6820 3361 885 683 -85 C

ATOM 540 O LYS A 102 -30.523 -1 463 -21.465 1 00 36.19 O

ANISOU 540 O LYS A 102 2562 7669 3517 564 1154 -429 O

ATOM 541 CB LYS A 102 -31.421 -0 151 -24.207 1 00 36.71 C

ANISOU 541 CB LYS A 102 2038 7266 4645 1176 1087 -155 C

ATOM 542 CG LYS A 102 -32.476 0 214 -25.242 1 00 39.88 C

ANISOU 542 CG LYS A 102 3441 7321 4387 313 278 80 C

ATOM 543 CD LYS A 102 -31.977 -0 006 -26.661 1 00 33.58 C

ANISOU 543 CD LYS A 102 525 7371 4861 950 940 1006 C

ATOM 544 CE LYS A 102 -33.019 0 423 -27.687 1 00 35.91 C

ANISOU 544 CE LYS A 102 3672 6221 3749 764 197 1458 C

ATOM 545 NZ LYS A 102 -32.912 -0 388 -28.933 1 00 31.65 N

ANISOU 545 NZ LYS A 102 3074 5729 3222 463 278 1729 N

ATOM 546 N LYS A 103 -29.123 -2 141 -23.066 1 00 29.47 N

ANISOU 546 N LYS A 103 2040 5214 3941 -125 722 364 N

ATOM 547 CA LYS A 103 -27.958 -2 280 -22.173 1 00 24.61 C

ANISOU 547 CA LYS A 103 2032 3650 3666 -269 651 245 C

ATOM 548 C LYS A 103 -26.679 -2 238 -23.002 1 00 22.09 C

ANISOU 548 C LYS A 103 2173 3313 2907 21 536 -211 C

ATOM 549 O LYS A 103 -26.721 -2 395 -24.225 1 00 22.48 O

ANISOU 549 O LYS A 103 2644 2970 2925 -432 798 -255 O

ATOM 550 CB LYS A 103 -28.024 -3 594 -21.380 1 00 22.15 C

ANISOU 550 CB LYS A 103 2359 3243 2813 178 544 -230 C

ATOM 551 CG LYS A 103 -28.002 -4 836 -22.251 1 00 26.50 C

ANISOU 551 CG LYS A 103 3758 2885 3422 -111 151 0 C

ATOM 552 CD LYS A 103 -28.142 -6 115 -21.447 1 00 27.52 C

ANISOU 552 CD LYS A 103 4088 2896 3471 57 157 3 C

ATOM 553 CE LYS A 103 -28.191 -7 324 -22.378 1 00 27.40 C

ANISOU 553 CE LYS A 103 3977 2837 3596 51 -44 15 C

ATOM 554 NZ LYS A 103 -27.216 -8 374 -21.950 1 00 31.44 N

ANISOU 554 NZ LYS A 103 4248 3389 4307 -311 280 457 N

ATOM 555 N HIS A 104 -25.552 -2 014 -22.355 1 00 20.31 N

ANISOU 555 N HIS A 104 2074 2648 2993 -405 689 -454 N

ATOM 556 CA HIS A 104 -24.270 -2 100 -23.052 1 00 18.70 C

ANISOU 556 CA HIS A 104 1555 2568 2980 -381 251 -170 C

ATOM 557 C HIS A 104 -24.023 -3 515 -23.475 1 00 18.19 C

ANISOU 557 C HIS A 104 1692 2436 2781 -685 325 -152 C

ATOM 558 O HIS A 104 -24.201 -4 453 -22.698 1 00 22.15 O

ANISOU 558 O HIS A 104 2451 2634 3330 -518 500 157 O

ATOM 559 CB HIS A 104 -23.129 -1 586 -22.180 1 00 19.83 C

ANISOU 559 CB HIS A 104 1613 2796 3124 -623 161 92 C

ATOM 560 CG HIS A 104 -23.208 -0 109 -21.891 1 00 19.76 C

ANISOU 560 CG HIS A 104 1527 2816 3163 -519 109 234 C

ATOM 561 ND1 HIS A 104 -22.827 0 827 -22.784 1 00 23.45 N

ANISOU 561 ND1 HIS A 104 2284 2876 3747 -557 73 491 N

ATOM 562 CD2 HIS A 104 -23.657 0 580 -20.772 1 00 19.42 C

ANISOU 562 CD2 HIS A 104 2282 2898 2197 -741 121 711 C

ATOM 563 CE1 HIS A 104 -23.018 2 049 -22.259 1 00 18.78 C

ANISOU 563 CE1 HIS A 104 1574 2649 2911 -472 46 550 C

ATOM 564 NE2 HIS A 104 -23.527 1 895 -21.028 1 00 22.93 N

ANISOU 564 NE2 HIS A 104 2961 2836 2913 -567 50 462 N ATOM 565 N VAL A 105 -23.626 -3 691 -24.726 1 00 16.37 N

ANISOU 565 N VAL A 105 2140 1684 2395 -871 -322 -170 N

ATOM 566 CA VAL A 105 -23.297 -5 005 -25.242 1 00 18.32 C

ANISOU 566 CA VAL A 105 2213 2065 2680 -463 -243 -393 C

ATOM 567 C VAL A 105 -21.932 -4 872 -25.908 1 00 19.18 C

ANISOU 567 C VAL A 105 2268 2295 2722 -106 -132 -10 C

ATOM 568 O VAL A 105 -21.765 -4 038 -26.804 1 00 18.09 O

ANISOU 568 O VAL A 105 2016 2081 2775 -337 13 -160 O

ATOM 569 CB VAL A 105 -24.340 -5 485 -26.282 1 00 19.75 C

ANISOU 569 CB VAL A 105 2121 2611 2770 -562 -255 -494 C

ATOM 570 CGI VAL A 105 -23.935 -6 829 -26.868 1 00 18.67 C

ANISOU 570 CGI VAL A 105 1800 2613 2678 -493 315 -280 C

ATOM 571 CG2 VAL A 105 -25.738 -5 583 -25.667 1 00 19.77 C

ANISOU 571 CG2 VAL A 105 2429 2008 3071 -624 162 -361 C

ATOM 572 N TRP A 106 -20.964 -5 678 -25.464 1 00 17.51 N

ANISOU 572 N TRP A 106 1858 2299 2496 -278 -176 -155 N

ATOM 573 CA TRP A 106 -19.624 -5 675 -26.056 1 00 18.89 C

ANISOU 573 CA TRP A 106 1934 2675 2567 17 -174 344 C

ATOM 574 C TRP A 106 -19.613 -6 296 -27.414 1 00 17.09 C

ANISOU 574 C TRP A 106 1454 2114 2926 -67 -159 37 C

ATOM 575 O TRP A 106 -20.068 -7 421 -27.580 1 00 19.37 O

ANISOU 575 O TRP A 106 1826 2200 3332 -270 193 -294 O

ATOM 576 CB TRP A 106 -18.623 -6 393 -25.155 1 00 18.19 C

ANISOU 576 CB TRP A 106 1852 2352 2705 -321 -339 488 C

ATOM 577 CG TRP A 106 -18.389 -5 626 -23.884 1 00 17.04 C

ANISOU 577 CG TRP A 106 2197 1818 2460 -468 424 598 C

ATOM 578 CD1 TRP A 106 -18.883 -5 910 -22.606 1 00 19.80 C

ANISOU 578 CD1 TRP A 106 2563 2465 2494 -530 412 608 C

ATOM 579 CD2 TRP A 106 -17.613 -4 401 -23.743 1 00 16.81 C

ANISOU 579 CD2 TRP A 106 1982 1919 2484 -384 -109 571 C

ATOM 580 NE1 TRP A 106 -18.467 -4 961 -21.710 1 00 22.21 N

ANISOU 580 NE1 TRP A 106 2665 2969 2806 -1162 -176 725 N

ATOM 581 CE2 TRP A 106 -17.707 -4 013 -22.335 1 00 18.06 C

ANISOU 581 CE2 TRP A 106 2347 2111 2401 -130 1 973 C

ATOM 582 CE3 TRP A 106 -16.888 -3 592 -24.630 1 00 14.62 C

ANISOU 582 CE3 TRP A 106 1397 1754 2402 -161 122 303 C

ATOM 583 CZ2 TRP A 106 -17.071 -2 879 -21.841 1 00 18.86 C

ANISOU 583 CZ2 TRP A 106 1818 2439 2907 -322 84 733 C

ATOM 584 CZ3 TRP A 106 -16.252 -2 445 -24.119 1 00 15.02 C

ANISOU 584 CZ3 TRP A 106 1334 2066 2307 -298 -584 565 C

ATOM 585 CH2 TRP A 106 -16.352 -2 097 -22.760 1 00 16.83 C

ANISOU 585 CH2 TRP A 106 1966 2034 2394 11 -53 677 C

ATOM 586 N PHE A 107 -19.084 -5 561 -28.386 1 00 18.51 N

ANISOU 586 N PHE A 107 2010 2186 2835 163 92 159 N

ATOM 587 CA PHE A 107 -18.938 -6 051 -29.753 1 00 18.60 C

ANISOU 587 CA PHE A 107 2229 1961 2877 -158 -272 36 C

ATOM 588 C PHE A 107 -18.148 -7 370 -29.796 1 00 20.32 C

ANISOU 588 C PHE A 107 2255 2030 3433 -126 -372 -214 C

ATOM 589 O PHE A 107 -18.640 -8 394 -30.315 1 00 21.29 O

ANISOU 589 O PHE A 107 2083 2242 3765 -244 -803 -273 O

ATOM 590 CB PHE A 107 -18.283 -4 968 -30.638 1 00 17.90 C

ANISOU 590 CB PHE A 107 1961 2193 2645 -243 -179 9 C

ATOM 591 CG PHE A 107 -17.895 -5 456 -32.014 1 00 19.66 C

ANISOU 591 CG PHE A 107 2112 2442 2916 -222 152 -100 C

ATOM 592 CD1 PHE A 107 -18.871 -5 691 -32.989 1 00 19.14 C

ANISOU 592 CD1 PHE A 107 2011 2344 2915 -200 191 -92 C

ATOM 593 CD2 PHE A 107 -16.546 -5 673 -32.344 1 00 18.73 C

ANISOU 593 CD2 PHE A 107 2149 2129 2835 -277 249 -142 C

ATOM 594 CE1 PHE A 107 -18.518 -6 148 -34.249 1 00 19.22 C

ANISOU 594 CE1 PHE A 107 2114 2504 2682 -585 517 311 C

ATOM 595 CE2 PHE A 107 -16.192 -6 135 -33.606 1 00 20.84 C ANISOU 595 CE2 PHE A 107 2819 2335 2765 -348 108 ^■126 C

ATOM 596 CZ PHE A 107 -17.175 -6. .372 -34. .557 1. .00 20. .16 C

ANISOU 596 CZ PHE A 107 2036 2309 3311 -150 55 -25 C

ATOM 597 N GLY A 108 -16.949 -7. .349 -29. .216 1. .00 19. .53 N

ANISOU 597 N GLY A 108 2144 2087 3188 -151 -186 383 N

ATOM 598 CA GLY A 108 -16.026 -8. .473 -29. .328 1. .00 21. .21 C

ANISOU 598 CA GLY A 108 2329 2044 3683 -102 -361 83 C

ATOM 599 C GLY A 108 -16.449 -9. .632 -28. .464 1. .00 22. .21 C

ANISOU 599 C GLY A 108 2758 1773 3906 75 -48 -55 C

ATOM 600 O GLY A 108 -16.357 -10. .788 -28. .870 1. .00 28. .67 O

ANISOU 600 O GLY A 108 4202 1889 4799 422 512 ^■307 O

ATOM 601 N GLU A 109 -16.939 -9. .308 -27. .285 1. .00 24. .49 N

ANISOU 601 N GLU A 109 2810 2768 3724 -118 127 265 N

ATOM 602 CA GLU A 109 -17.365 -10. .294 -26. .330 1. .00 24. .08 C

ANISOU 602 CA GLU A 109 3117 2553 3476 -40 -8 151 C

ATOM 603 C GLU A 109 -18.636 -11. .021 -26. .730 1. .00 24. .60 C

ANISOU 603 C GLU A 109 3050 2180 4117 -262 389 67 C

ATOM 604 O GLU A 109 -18.702 -12. .213 -26. .584 1. .00 28. .16 O

ANISOU 604 O GLU A 109 3332 2414 4951 -14 100 933 O

ATOM 605 CB GLU A 109 -17.574 -9. .647 -24. .968 1. .00 23. .79 C

ANISOU 605 CB GLU A 109 2693 3057 3288 -163 -1 236 C

ATOM 606 CG GLU A 109 -16.380 -9. .707 -24. .044 1. .00 26. .61 c

ANISOU 606 CG GLU A 109 3277 3793 3037 -57 -246 -63 c

ATOM 607 CD GLU A 109 -15.933 -11. .132 -23. .811 1. .00 28. .17 c

ANISOU 607 CD GLU A 109 3057 4404 3242 -400 74 ^■196 c

ATOM 608 OE1 GLU A 109 -16.787 -12. .031 -23. .959 1. .00 33. .24 0

ANISOU 608 OE1 GLU A 109 3451 5019 4156 -198 387 362 0

ATOM 609 OE2 GLU A 109 -14.742 -11. .347 -23. .502 1. .00 31. .50 0

ANISOU 609 OE2 GLU A 109 3546 4318 4104 -525 -367 -46 0

ATOM 610 N SER A 110 -19.633 -10. .293 -27. .227 1. .00 27. .07 N

ANISOU 610 N SER A 110 3286 3038 3959 -331 -12 225 N

ATOM 611 CA SER A 110 -21.018 -10. .782 -27. .279 1. .00 26. .41 C

ANISOU 611 CA SER A 110 3237 2818 3979 -391 566 -1 C

ATOM 612 C SER A 110 -21.701 -10. .878 -28. .640 1. .00 26. .45 C

ANISOU 612 C SER A 110 3480 2375 4192 -409 300 185 C

ATOM 613 O SER A 110 -22.646 -11. .658 -28. .788 1. .00 30. .88 0

ANISOU 613 O SER A 110 3524 2937 5270 -658 118 547 0

ATOM 614 CB SER A 110 -21.908 -9. .935 -26. .359 1. .00 25. .44 c

ANISOU 614 CB SER A 110 3352 2627 3686 245 -4 86 c

ATOM 615 OG SER A 110 -21.472 -10. .022 -25. .022 1. .00 30. .16 0

ANISOU 615 OG SER A 110 4028 4136 3293 -260 765 515 0

ATOM 616 N MET A 111 -21.264 -10. .096 -29. .623 1. .00 22. .97 N

ANISOU 616 N MET A 111 3117 2080 3531 -136 -94 ^■115 N

ATOM 617 CA MET A 111 -21.990 -10. .037 -30. .899 1. .00 23. .09 C

ANISOU 617 CA MET A 111 3306 2018 3449 -645 -120 134 C

ATOM 618 C MET A 111 -21.519 -11. .075 -31. .912 1. .00 26. .03 C

ANISOU 618 C MET A 111 3500 2232 4155 -909 -430 ^■490 C

ATOM 619 O MET A 111 -20.332 -11. .411 -31. .959 1. .00 26. .77 O

ANISOU 619 O MET A 111 3328 2457 4387 -1122 -1194 ^■560 0

ATOM 620 CB MET A 111 -21.920 -8. .633 -31. .507 1. .00 19. .39 c

ANISOU 620 CB MET A 111 2181 1774 3410 -683 114 -88 c

ATOM 621 CG MET A 111 -22.476 -7. .554 -30. .595 1. .00 23. .42 c

ANISOU 621 CG MET A 111 3390 1788 3719 -627 -425 ^■645 c

ATOM 622 SD MET A 111 -22.507 -5. .918 -31. .354 1. .00 19. .92 s

ANISOU 622 SD MET A 111 2298 2415 2854 -547 -83 ^■178 s

ATOM 623 CE MET A 111 -22.751 -4. .878 -29. .914 1. .00 19. .31 c

ANISOU 623 CE MET A 111 2463 1291 3580 -951 103 ^■278 c

ATOM 624 N ASP A 112 -22.460 -11. .578 -32. .717 1. .00 26. .65 N

ANISOU 624 N ASP A 112 3041 2581 4503 -1195 -238 ^■501 N

ATOM 625 CA ASP A 112 -22.158 -12. .522 -33. .796 1. .00 30. .72 C

ANISOU 625 CA ASP A 112 3678 3212 4781 -776 -84 ^■813 C ATOM 626 C ASP A 112 -21.257 -11 875 -34.833 1 00 29.08 C

ANISOU 626 C ASP A 112 3143 3058 4846 -613 16 -1100 C

ATOM 627 O ASP A 112 -21.589 -10 833 -35.405 1 00 32.20 O

ANISOU 627 O ASP A 112 3296 3768 5169 -232 214 -863 O

ATOM 628 CB ASP A 112 -23.440 -13 029 -34.462 1 00 36.18 C

ANISOU 628 CB ASP A 112 3781 3867 6100 -276 -1254 -137 C

ATOM 629 CG ASP A 112 -24.241 -13 959 -33.570 1 00 48.43 C

ANISOU 629 CG ASP A 112 5723 5327 7349 -907 -764 696 C

ATOM 630 OD1 ASP A 112 -23.669 -14 546 -32.625 1 00 61.46 O

ANISOU 630 OD1 ASP A 112 7864 6940 8548 -1343 -2061 1351 O

ATOM 631 OD2 ASP A 112 -25.451 -14 116 -33.824 1 00 57.68 O

ANISOU 631 OD2 ASP A 112 6491 6899 8524 -1775 -1825 714 O

ATOM 632 N GLY A 113 -20.107 -12 497 -35.062 1 00 27.59 N

ANISOU 632 N GLY A 113 3529 2211 4742 -322 198 -42 N

ATOM 633 CA GLY A 113 -19.111 -11 953 -35.961 1 00 25.72 C

ANISOU 633 CA GLY A 113 2990 2518 4262 -949 41 -822 C

ATOM 634 C GLY A 113 -18.230 -10 899 -35.300 1 00 23.83 C

ANISOU 634 C GLY A 113 3082 2709 3262 -539 -568 -726 C

ATOM 635 O GLY A 113 -17.382 -10 298 -35.957 1 00 26.42 O

ANISOU 635 O GLY A 113 2619 3264 4154 -309 -39 -981 O

ATOM 636 N GLY A 114 -18.424 -10 676 -34.001 1 00 22.25 N

ANISOU 636 N GLY A 114 2302 2508 3642 -379 -290 -1503 N

ATOM 637 CA GLY A 114 -17.654 -9 670 -33.278 1 00 21.95 C

ANISOU 637 CA GLY A 114 2482 2428 3427 -386 -871 -949 C

ATOM 638 C GLY A 114 -16.233 -10 142 -33.060 1 00 21.06 C

ANISOU 638 C GLY A 114 2197 2228 3575 -492 -44 -736 C

ATOM 639 O GLY A 114 -15.951 -11 330 -33.109 1 00 24.04 O

ANISOU 639 O GLY A 114 3091 2386 3656 -189 31 -1217 O

ATOM 640 N PHE A 115 -15.336 -9 199 -32.837 1 00 19.60 N

ANISOU 640 N PHE A 115 2472 2049 2924 -463 -428 -522 N

ATOM 641 CA PHE A 115 -13.945 -9 504 -32.529 1 00 22.52 C

ANISOU 641 CA PHE A 115 2664 2531 3358 -53 -320 -512 C

ATOM 642 C PHE A 115 -13.377 -8 405 -31.657 1 00 19.34 C

ANISOU 642 C PHE A 115 2298 2413 2636 54 -483 -99 C

ATOM 643 O PHE A 115 -13.820 -7 254 -31.734 1 00 19.96 O

ANISOU 643 O PHE A 115 2413 2353 2815 -10 242 -179 O

ATOM 644 CB PHE A 115 -13.104 -9 649 -33.817 1 00 21.42 C

ANISOU 644 CB PHE A 115 2283 2369 3485 87 -251 -619 C

ATOM 645 CG PHE A 115 -13.259 -8 504 -34.801 1 00 20.99 C

ANISOU 645 CG PHE A 115 2167 2559 3249 152 -398 -660 C

ATOM 646 CD1 PHE A 115 -12.444 -7 369 -34.717 1 00 24.30 C

ANISOU 646 CD1 PHE A 115 2977 2315 3939 48 -19 -405 C

ATOM 647 CD2 PHE A 115 -14.195 -8 572 -35.838 1 00 22.70 C

ANISOU 647 CD2 PHE A 115 2105 3170 3348 483 -477 -437 C

ATOM 648 CE1 PHE A 115 -12.571 -6 322 -35.631 1 00 23.88 C

ANISOU 648 CE1 PHE A 115 3084 2492 3497 -22 174 -480 C

ATOM 649 CE2 PHE A 115 -14.326 -7 525 -36.754 1 00 25.72 C

ANISOU 649 CE2 PHE A 115 2670 3234 3866 319 140 -180 C

ATOM 650 CZ PHE A 115 -13.516 -6 397 -36.649 1 00 24.62 C

ANISOU 650 CZ PHE A 115 2479 3064 3810 587 248 -368 C

ATOM 651 N GLN A 116 -12.411 -8 758 -30.814 1 00 20.00 N

ANISOU 651 N GLN A 116 2148 2557 2891 2 -611 -162 N

ATOM 652 CA GLN A 116 -11.637 -7 749 -30.105 1 00 19.53 C

ANISOU 652 CA GLN A 116 2427 2435 2558 -127 -272 -64 C

ATOM 653 C GLN A 116 -10.576 -7 182 -31.038 1 00 18.28 C

ANISOU 653 C GLN A 116 2456 1575 2912 155 13 -230 C

ATOM 654 O GLN A 116 -10.129 -7 861 -31.965 1 00 21.49 O

ANISOU 654 O GLN A 116 2923 1935 3307 247 545 -367 O

ATOM 655 CB GLN A 116 -11.031 -8 348 -28.841 1 00 23.12 C

ANISOU 655 CB GLN A 116 2639 3129 3015 -52 -260 630 C

ATOM 656 CG GLN A 116 -12.120 -9 007 -28.000 1 00 31.13 C ANISOU 656 CG GLN A 116 3489 4230 4108 -647 345 833 C

ATOM 657 CD GLN A 116 -11.992 -8. ,700 -26. .539 1. .00 38. .11 C

ANISOU 657 CD GLN A 116 4612 5481 4384 -43 -901 992 C

ATOM 658 OE1 GLN A 116 -10.925 -8. ,863 -25. .960 1. .00 39. .56 O

ANISOU 658 OE1 GLN A 116 5163 4372 5496 1292 -1146 2455 O

ATOM 659 NE2 GLN A 116 -13.090 -8. ,253 -25. .923 1. .00 42. .09 N

ANISOU 659 NE2 GLN A 116 5071 3943 6978 1090 -1060 1041 N

ATOM 660 N PHE A 117 -10.209 -5. ,928 -30. .824 1. .00 16. .42 N

ANISOU 660 N PHE A 117 1975 1781 2482 -295 3 -83 N

ATOM 661 CA PHE A 117 -9.256 -5. ,264 -31. .708 1. .00 16. .13 C

ANISOU 661 CA PHE A 117 2124 1552 2452 104 369 -160 C

ATOM 662 C PHE A 117 -7.841 -5. ,728 -31. .449 1. .00 18. .38 C

ANISOU 662 C PHE A 117 2346 2017 2620 222 181 132 C

ATOM 663 O PHE A 117 -7.422 -5. ,902 -30. .300 1. .00 18. .70 O

ANISOU 663 O PHE A 117 2236 2425 2441 158 490 147 O

ATOM 664 CB PHE A 117 -9.370 -3. ,731 -31. .622 1. .00 14. .57 C

ANISOU 664 CB PHE A 117 1462 1509 2565 -143 -37 -381 C

ATOM 665 CG PHE A 117 -10.781 -3. ,226 -31. .710 1. .00 17. .02 C

ANISOU 665 CG PHE A 117 1877 1863 2727 458 67 -369 C

ATOM 666 CD1 PHE A 117 -11.656 -3. ,746 -32. .666 1. .00 17. .42 C

ANISOU 666 CD1 PHE A 117 1926 1926 2766 181 -116 124 C

ATOM 667 CD2 PHE A 117 -11.249 -2. ,243 -30. .828 1. .00 17. .78 C

ANISOU 667 CD2 PHE A 117 1858 2064 2832 661 105 -413 C

ATOM 668 CE1 PHE A 117 -12.967 -3. ,298 -32. .746 1. .00 17. .12 C

ANISOU 668 CE1 PHE A 117 2039 1409 3057 415 165 -170 C

ATOM 669 CE2 PHE A 117 -12.561 -1. ,783 -30. .912 1. .00 14. .60 c

ANISOU 669 CE2 PHE A 117 1664 1789 2095 305 -32 89 c

ATOM 670 CZ PHE A 117 -13.421 -2. ,319 -31. .872 1. .00 15. .34 c

ANISOU 670 CZ PHE A 117 1885 2013 1929 40 247 -222 c

ATOM 671 N SER A 118 -7.114 -5. ,895 -32. .547 1. .00 20. .46 N

ANISOU 671 N SER A 118 2697 2213 2863 336 399 -195 N

ATOM 672 CA SER A 118 -5.813 -6. ,512 -32. .559 1. .00 19. .95 C

ANISOU 672 CA SER A 118 2452 1837 3291 -120 586 -208 C

ATOM 673 C SER A 118 -4.873 -5. ,549 -33. .293 1. .00 19. .89 C

ANISOU 673 C SER A 118 2924 1714 2917 27 382 221 C

ATOM 674 O SER A 118 -5.315 -4. ,846 -34. .200 1. .00 21. .54 O

ANISOU 674 O SER A 118 2953 2151 3080 67 512 641 0

ATOM 675 CB SER A 118 -5.944 -7. ,857 -33. .292 1. .00 23. .98 c

ANISOU 675 CB SER A 118 3211 2006 3895 723 128 -607 c

ATOM 676 OG SER A 118 -4.705 -8. ,456 -33. .477 1. .00 29. .96 0

ANISOU 676 OG SER A 118 2389 3720 5275 197 340 108 0

ATOM 677 N TYR A 119 -3.602 -5. ,501 -32. .886 1. .00 19. .81 N

ANISOU 677 N TYR A 119 2611 1475 3438 412 773 -53 N

ATOM 678 CA TYR A 119 -2.625 -4. ,505 -33. .381 1. .00 19. .52 C

ANISOU 678 CA TYR A 119 2431 1561 3423 432 993 -271 C

ATOM 679 C TYR A 119 -1.335 -5. ,149 -33. .838 1. .00 25. .37 C

ANISOU 679 C TYR A 119 2814 2364 4459 728 1676 -16 C

ATOM 680 O TYR A 119 -0.865 -6. ,111 -33. .227 1. .00 28. .02 O

ANISOU 680 O TYR A 119 2946 2173 5526 635 2184 428 0

ATOM 681 CB TYR A 119 -2.292 -3. ,474 -32. .290 1. .00 17. .91 c

ANISOU 681 CB TYR A 119 1893 1529 3382 453 684 -128 c

ATOM 682 CG TYR A 119 -3.526 -2. ,742 -31. .874 1. .00 14. .70 c

ANISOU 682 CG TYR A 119 1586 1836 2160 365 387 -31 c

ATOM 683 CD1 TYR A 119 -4.415 -3. ,317 -30. .968 1. .00 14. .77 c

ANISOU 683 CD1 TYR A 119 1885 1494 2233 38 220 131 c

ATOM 684 CD2 TYR A 119 -3.860 -1. ,517 -32. .452 1. .00 15. .86 c

ANISOU 684 CD2 TYR A 119 2001 1729 2295 251 -47 -167 c

ATOM 685 CE1 TYR A 119 -5.599 -2. ,684 -30. .630 1. .00 13. .59 c

ANISOU 685 CE1 TYR A 119 1988 1433 1744 204 -110 -431 c

ATOM 686 CE2 TYR A 119 -5.029 -0. ,871 -32. .109 1. .00 16. .12 c

ANISOU 686 CE2 TYR A 119 2227 1882 2016 315 103 -320 c ATOM 687 CZ TYR A 119 -5.894 -1..464 -31..205 1..00 14..30 C

ANISOU 687 CZ TYR A 119 2013 1408 2010 223 -47 -429 C

ATOM 688 OH TYR A 119 -7.054 -0. .828 -30. .882 1. .00 13. .91 O

ANISOU 688 OH TYR A 119 1694 1387 2201 227 -246 -99 O

ATOM 689 N GLY A 120 -0.743 -4. .597 -34. .891 1. .00 27. .08 N

ANISOU 689 N GLY A 120 3567 2442 4278 -60 1593 -384 N

ATOM 690 CA GLY A 120 0.549 -5. .072 -35. .342 1. .00 33. .41 C

ANISOU 690 CA GLY A 120 4015 3605 5072 -62 2464 -52 C

ATOM 691 C GLY A 120 0.437 -6. .054 -36. .477 1. .00 36. .49 C

ANISOU 691 C GLY A 120 4629 3544 5690 -317 3778 -561 C

ATOM 692 O GLY A 120 -0.664 -6. .511 -36. .820 1. .00 36. .59 O

ANISOU 692 O GLY A 120 6744 3095 4063 -324 2379 - 1752 O

ATOM 693 N ASN A 121 1.606 -6. .359 -37. .038 1. .00 46. .22 N

ANISOU 693 N ASN A 121 7108 4609 5845 2024 4631 520 N

ATOM 694 CA ASN A 121 1.810 -7. .232 -38. .178 1. .00 55. .72 C

ANISOU 694 CA ASN A 121 9929 5184 6056 576 2270 - 1017 C

ATOM 695 C ASN A 121 1.198 -8. .611 -37. .878 1. .00 53. .08 C

ANISOU 695 C ASN A 121 9174 5050 5943 448 1186 - 2054 C

ATOM 696 O ASN A 121 1.792 -9. .398 -37. .136 1. .00 57. .21 O

ANISOU 696 O ASN A 121 10473 6510 4751 1268 2191 - 1269 O

ATOM 697 CB ASN A 121 3.335 -7. .351 -38. .488 1. .00 53. .87 C

ANISOU 697 CB ASN A 121 9668 4377 6423 934 1778 -713 C

ATOM 698 CG ASN A 121 4.137 -6. .042 -38. .230 1. .00 47. .72 c

ANISOU 698 CG ASN A 121 7188 6527 4414 325 1227 - 1210 c

ATOM 699 OD1 ASN A 121 5.156 -5. .789 -38. .887 1. .00 38. .31 0

ANISOU 699 OD1 ASN A 121 5622 3690 5240 -417 -171 1012 0

ATOM 700 ND2 ASN A 121 3.701 -5. .232 -37. .259 1. .00 37. .56 N

ANISOU 700 ND2 ASN A 121 6185 2796 5289 570 -1569 - 1642 N

ATOM 701 N PRO A 122 0.000 -8. .907 -38. .434 1. .00 51. .70 N

ANISOU 701 N PRO A 122 9629 5709 4305 1171 341 - 2990 N

ATOM 702 CA PRO A 122 -0.646 -10. .183 -38. .087 1. .00 55. .08 C

ANISOU 702 CA PRO A 122 9656 6055 5216 1712 938 - 1856 C

ATOM 703 C PRO A 122 0.179 -11. .387 -38. .542 1. .00 56. .76 C

ANISOU 703 C PRO A 122 11153 4651 5759 1424 502 - 2025 C

ATOM 704 O PRO A 122 -0.246 -12. .529 -38. .350 1. .00 58. .86 O

ANISOU 704 O PRO A 122 11430 4585 6348 433 -711 - 2670 O

ATOM 705 CB PRO A 122 -1.990 -10. .138 -38. .838 1. .00 48. .17 C

ANISOU 705 CB PRO A 122 9275 4450 4577 1312 1247 - 2315 C

ATOM 706 CG PRO A 122 -2.084 -8. .786 -39. .459 1. .00 43. .71 C

ANISOU 706 CG PRO A 122 8676 4672 3258 840 1046 - 2041 C

ATOM 707 CD PRO A 122 -0.692 -8. .233 -39. .546 1. .00 51. .55 C

ANISOU 707 CD PRO A 122 8431 5000 6155 1843 1299 - 1463 c

ATOM 708 N GLU A 123 1.343 -11. .112 -39. .138 1. .00 60. .86 N

ANISOU 708 N GLU A 123 10968 6485 5667 1795 733 - 3688 N

ATOM 709 CA GLU A 123 2.316 -12. .138 -39. .529 1. .00 56. .49 C

ANISOU 709 CA GLU A 123 10595 5889 4978 2325 546 -740 C

ATOM 710 C GLU A 123 3.083 -12. .682 -38. .328 1. .00 53. .64 C

ANISOU 710 C GLU A 123 9500 4490 6390 1540 -76 -317 C

ATOM 711 O GLU A 123 3.193 -13. .899 -38. .174 1. .00 62. .13 O

ANISOU 711 O GLU A 123 11199 4862 7543 1537 769 752 O

ATOM 712 CB GLU A 123 3.301 -11. .598 -40. .575 1. .00 54. .93 c

ANISOU 712 CB GLU A 123 10297 5518 5056 1340 -14 -72 c

ATOM 713 N LEU A 124 3.613 -11. .783 -37. .492 1. .00 38. .65 N

ANISOU 713 N LEU A 124 5890 4401 4392 2643 297 230 N

ATOM 714 CA LEU A 124 4.331 -12. .163 -36. .285 1. .00 32. .29 C

ANISOU 714 CA LEU A 124 5280 3169 3816 -182 -191 -847 C

ATOM 715 C LEU A 124 3.374 -12. .903 -35. .349 1. .00 35. .32 C

ANISOU 715 C LEU A 124 4745 3737 4938 651 -46 216 C

ATOM 716 O LEU A 124 2.177 -12. .579 -35. .299 1. .00 35. .34 O

ANISOU 716 O LEU A 124 4158 5645 3622 16 497 260 O

ATOM 717 CB LEU A 124 4.930 -10. .926 -35. .580 1. .00 36. .08 c ANISOU 717 CB LEU A 124 6485 2890 4331 -37 80 - 1207 C

ATOM 718 N PRO A 125 3.884 -13. .911 -34. .617 1. .00 35. .67 N

ANISOU 718 N PRO A 125 5010 3109 5433 547 -255 72 N

ATOM 719 CA PRO A 125 3.061 -14. .551 -33. .592 1. .00 30. .52 C

ANISOU 719 CA PRO A 125 4349 2554 4691 913 -1124 395 C

ATOM 720 C PRO A 125 2.487 -13. .516 -32. .621 1. .00 29. .43 C

ANISOU 720 C PRO A 125 4250 2615 4314 403 -977 346 C

ATOM 721 O PRO A 125 3.118 -12. .480 -32. .393 1. .00 31. .01 O

ANISOU 721 O PRO A 125 4854 3060 3868 -225 -1107 138 O

ATOM 722 CB PRO A 125 4.059 -15. .459 -32. .875 1. .00 33. .15 C

ANISOU 722 CB PRO A 125 4740 3019 4834 1589 -1444 -6 C

ATOM 723 CG PRO A 125 5.056 -15. .808 -33. .929 1. .00 35. .45 C

ANISOU 723 CG PRO A 125 5132 2884 5453 1095 -875 265 c

ATOM 724 CD PRO A 125 5.206 -14. .558 -34. .742 1. .00 34. .45 c

ANISOU 724 CD PRO A 125 4888 2695 5506 304 -814 -171 c

ATOM 725 N GLU A 126 1.303 -13. .797 -32. .072 1. .00 28. .74 N

ANISOU 725 N GLU A 126 3905 3427 3586 195 -1450 483 N

ATOM 726 CA GLU A 126 0.612 -12. .882 -31. .148 1. .00 29. .77 C

ANISOU 726 CA GLU A 126 3681 3777 3853 -408 -755 347 C

ATOM 727 C GLU A 126 1.469 -12. .548 -29. .922 1. .00 26. .86 C

ANISOU 727 C GLU A 126 3471 2846 3887 452 -850 295 C

ATOM 728 O GLU A 126 1.418 -11. .434 -29. .407 1. .00 27. .60 O

ANISOU 728 O GLU A 126 3630 2690 4164 -881 -1150 182 O

ATOM 729 CB GLU A 126 -0.743 -13. .466 -30. .715 1. .00 27. .65 c

ANISOU 729 CB GLU A 126 3046 4032 3425 -247 -1371 449 c

ATOM 730 N ASP A 127 2.261 -13. .515 -29. .468 1. .00 26. .17 N

ANISOU 730 N ASP A 127 3987 2606 3349 216 -1425 305 N

ATOM 731 CA ASP A 127 3.090 -13. .322 -28. .276 1. .00 26. .76 C

ANISOU 731 CA ASP A 127 3246 2629 4291 -8 -1775 54 C

ATOM 732 C ASP A 127 4.271 -12. .388 -28. .511 1. .00 26. .53 C

ANISOU 732 C ASP A 127 3489 2984 3604 41 -526 78 C

ATOM 733 O ASP A 127 4.666 -11. .645 -27. .604 1. .00 25. .43 O

ANISOU 733 O ASP A 127 2745 2958 3959 90 -543 63 O

ATOM 734 CB ASP A 127 3.546 -14. .671 -27. .714 1. .00 29. .26 c

ANISOU 734 CB ASP A 127 4523 2521 4070 -98 -1732 56 c

ATOM 735 CG ASP A 127 2.406 -15. .445 -27. .091 1. .00 26. .96 c

ANISOU 735 CG ASP A 127 3582 3084 3574 250 -2038 -425 c

ATOM 736 OD1 ASP A 127 1.274 -14. .903 -26. .999 1. .00 30. .78 0

ANISOU 736 OD1 ASP A 127 3607 3666 4421 344 -1108 87 0

ATOM 737 OD2 ASP A 127 2.627 -16. .600 -26. .703 1. .00 32. .96 0

ANISOU 737 OD2 ASP A 127 5289 3266 3967 934 -1989 -447 0

ATOM 738 N VAL A 128 4.821 -12. .400 -29. .723 1. .00 25. .94 N

ANISOU 738 N VAL A 128 3518 2448 3889 132 -412 491 N

ATOM 739 CA VAL A 128 5.862 -11. .444 -30. .065 1. .00 23. .57 C

ANISOU 739 CA VAL A 128 2956 2951 3048 -14 -94 -239 C

ATOM 740 C VAL A 128 5.327 -10. .004 -30. .054 1. .00 23. .42 C

ANISOU 740 C VAL A 128 2871 2959 3066 -30 -699 -361 C

ATOM 741 O VAL A 128 5.950 -9. .105 -29. .468 1. .00 22. .98 0

ANISOU 741 O VAL A 128 2499 3361 2869 -385 -398 -306 0

ATOM 742 CB VAL A 128 6.526 -11. .765 -31. .420 1. .00 25. .22 c

ANISOU 742 CB VAL A 128 3236 3475 2871 -233 -257 -433 c

ATOM 743 CGI VAL A 128 7.448 -10. .626 -31. .828 1. .00 28. .80 c

ANISOU 743 CGI VAL A 128 3129 4232 3579 -727 -131 -590 c

ATOM 744 CG2 VAL A 128 7.291 -13. .076 -31. .327 1. .00 30. .46 c

ANISOU 744 CG2 VAL A 128 3554 3895 4123 93 -39 - 1354 c

ATOM 745 N LEU A 129 4.173 -9. .786 -30. .678 1. .00 24. .14 N

ANISOU 745 N LEU A 129 2606 2971 3593 -357 -718 -432 N

ATOM 746 CA LEU A 129 3.579 -8. .446 -30. .744 1. .00 24. .70 C

ANISOU 746 CA LEU A 129 2865 3232 3286 -12 -1562 -672 C

ATOM 747 C LEU A 129 3.223 -7. .983 -29. .349 1. .00 22. .59 C

ANISOU 747 C LEU A 129 2637 2588 3356 -23 -928 -171 C ATOM 748 O LEU A 129 3.372 -6 811 -29.001 1 00 22.75 O

ANISOU 748 O LEU A 129 2613 2330 3701 -32 -1205 -51 O

ATOM 749 CB LEU A 129 2.333 -8 441 -31.637 1 00 25.52 C

ANISOU 749 CB LEU A 129 2533 3435 3728 -342 -1503 -14 C

ATOM 750 CG LEU A 129 2.641 -8 767 -33.097 1 00 28.00 C

ANISOU 750 CG LEU A 129 3695 2995 3946 -588 -1575 -422 C

ATOM 751 CD1 LEU A 129 1.370 -9 095 -33.875 1 00 31.75 C

ANISOU 751 CD1 LEU A 129 2242 4362 5459 -469 -1022 -74 C

ATOM 752 CD2 LEU A 129 3.395 -7 618 -33.754 1 00 32.72 C

ANISOU 752 CD2 LEU A 129 3201 4398 4832 -998 -1567 375 C

ATOM 753 N ASP A 130 2.756 -8 926 -28.548 1 00 21.84 N

ANISOU 753 N ASP A 130 2747 2877 2671 -326 -1119 -216 N

ATOM 754 CA ASP A 130 2.434 -8 725 -27.149 1 00 22.53 C

ANISOU 754 CA ASP A 130 2612 2896 3052 -323 -285 -302 C

ATOM 755 C ASP A 130 3.601 -8 086 -26.382 1 00 20.07 C

ANISOU 755 C ASP A 130 2203 2692 2730 65 -92 -561 C

ATOM 756 O ASP A 130 3.422 -7 136 -25.658 1 00 17.44 O

ANISOU 756 O ASP A 130 1284 2808 2532 220 -232 -581 O

ATOM 757 CB ASP A 130 2.098 -10 091 -26.540 1 00 25.17 C

ANISOU 757 CB ASP A 130 2876 3413 3273 -238 -364 79 C

ATOM 758 CG ASP A 130 1.734 -10 034 -25.063 1 00 31.99 C

ANISOU 758 CG ASP A 130 3605 4872 3675 81 234 445 C

ATOM 759 OD1 ASP A 130 0.713 -9 437 -24.740 1 00 41.76 O

ANISOU 759 OD1 ASP A 130 4269 6021 5576 389 -697 -106 O

ATOM 760 OD2 ASP A 130 2.449 -10 655 -24.228 1 00 33.42 O

ANISOU 760 OD2 ASP A 130 4833 4393 3471 65 -382 319 O

ATOM 761 N VAL A 131 4.788 -8 644 -26.557 1 00 17.97 N

ANISOU 761 N VAL A 131 1985 2375 2465 -117 -235 -222 N

ATOM 762 CA VAL A 131 5.962 -8 173 -25.832 1 00 15.15 C

ANISOU 762 CA VAL A 131 1782 1989 1982 438 -328 -83 C

ATOM 763 C VAL A 131 6.407 -6 799 -26.348 1 00 16.10 C

ANISOU 763 C VAL A 131 1819 2217 2081 -61 -168 -217 C

ATOM 764 O VAL A 131 6.703 -5 891 -25.561 1 00 14.39 O

ANISOU 764 O VAL A 131 1540 1707 2220 195 -240 -3 O

ATOM 765 CB VAL A 131 7.093 -9 214 -25.887 1 00 14.30 C

ANISOU 765 CB VAL A 131 1600 2111 1720 429 -305 -47 C

ATOM 766 CGI VAL A 131 8.405 -8 594 -25.417 1 00 13.38 C

ANISOU 766 CGI VAL A 131 1350 1876 1857 386 84 84 C

ATOM 767 CG2 VAL A 131 6.703 -10 428 -25.050 1 00 17.23 C

ANISOU 767 CG2 VAL A 131 2246 2090 2208 358 -426 40 C

ATOM 768 N GLN A 132 6.396 -6 630 -27.666 1 00 15.84 N

ANISOU 768 N GLN A 132 1692 2188 2139 249 -180 104 N

ATOM 769 CA GLN A 132 6.768 -5 351 -28.254 1 00 15.90 C

ANISOU 769 CA GLN A 132 1942 2150 1948 35 -246 -121 C

ATOM 770 C GLN A 132 5.823 -4 260 -27.782 1 00 15.31 C

ANISOU 770 C GLN A 132 1167 2150 2500 -44 -391 -16 C

ATOM 771 O GLN A 132 6.267 -3 187 -27.371 1 00 14.84 O

ANISOU 771 O GLN A 132 1353 2156 2127 125 -475 49 O

ATOM 772 CB GLN A 132 6.828 -5 431 -29.785 1 00 17.54 C

ANISOU 772 CB GLN A 132 2199 2586 1877 289 249 -359 C

ATOM 773 CG GLN A 132 7.922 -6 377 -30.316 1 00 16.04 C

ANISOU 773 CG GLN A 132 2537 1721 1834 478 -234 -118 C

ATOM 774 CD GLN A 132 9.322 -5 786 -30.211 1 00 16.81 C

ANISOU 774 CD GLN A 132 2507 2468 1409 460 -197 -332 C

ATOM 775 OE1 GLN A 132 9.689 -5 156 -29.189 1 00 15.07 O

ANISOU 775 OE1 GLN A 132 2528 2009 1188 415 106 -236 O

ATOM 776 NE2 GLN A 132 10.113 -5 961 -31.267 1 00 15.94 N

ANISOU 776 NE2 GLN A 132 2220 2080 1754 719 -70 -12 N

ATOM 777 N LEU A 133 4.517 -4 555 -27.784 1 00 15.31 N

ANISOU 777 N LEU A 133 1131 1991 2696 81 160 253 N

ATOM 778 CA LEU A 133 3.531 -3 615 -27.259 1 00 15.88 C ANISOU 778 CA LEU A 133 1626 1937 2467 417 -297 39 C

ATOM 779 C LEU A 133 3.664 -3. .357 -25. .766 1. .00 15. .68 C

ANISOU 779 C LEU A 133 1540 1890 2525 183 -147 -79 C

ATOM 780 O LEU A 133 3.431 -2. .226 -25. .314 1. .00 15. .75 O

ANISOU 780 O LEU A 133 1744 1847 2392 400 -17 52 O

ATOM 781 CB LEU A 133 2.124 -4. .100 -27. .545 1. .00 20. .16 C

ANISOU 781 CB LEU A 133 2118 2685 2855 -172 -710 -224 C

ATOM 782 CG LEU A 133 1.420 -3. .575 -28. .787 1. .00 25. .93 C

ANISOU 782 CG LEU A 133 3117 2799 3934 -403 -1580 398 C

ATOM 783 CD1 LEU A 133 0.138 -4. .378 -28. .938 1. .00 32. .61 C

ANISOU 783 CD1 LEU A 133 3460 3796 5132 -1204 -559 715 C

ATOM 784 CD2 LEU A 133 1.114 -2. .086 -28. .685 1. .00 25. .28 C

ANISOU 784 CD2 LEU A 133 2159 3060 4385 -63 -1090 248 C

ATOM 785 N ALA A 134 4.026 -4. .396 -25. .007 1. .00 15. .43 N

ANISOU 785 N ALA A 134 1603 1857 2403 152 29 -9 N

ATOM 786 CA ALA A 134 4.261 -4. .262 -23. .565 1. .00 16. .35 C

ANISOU 786 CA ALA A 134 1827 1975 2410 -269 -181 103 C

ATOM 787 C ALA A 134 5.386 -3. .258 -23. .274 1. .00 14. .12 C

ANISOU 787 C ALA A 134 1431 2040 1894 -47 -127 -50 C

ATOM 788 O ALA A 134 5.255 -2. .438 -22. .357 1. .00 13. .33 O

ANISOU 788 O ALA A 134 1536 1792 1737 276 -136 90 O

ATOM 789 CB ALA A 134 4.569 -5. .612 -22. .922 1. .00 16. .13 C

ANISOU 789 CB ALA A 134 1622 2031 2475 -10 -176 100 C

ATOM 790 N PHE A 135 6.477 -3. .312 -24. .056 1. .00 13. .29 N

ANISOU 790 N PHE A 135 1384 1998 1666 75 -189 112 N

ATOM 791 CA PHE A 135 7.537 -2. .299 -23. .937 1. .00 12. .22 C

ANISOU 791 CA PHE A 135 1135 1948 1557 201 35 139 C

ATOM 792 C PHE A 135 6.997 -0. .885 -24. .153 1. .00 12. .19 C

ANISOU 792 C PHE A 135 1104 1914 1611 143 -163 3 C

ATOM 793 O PHE A 135 7.320 0, .036 -23. .400 1. .00 13. .53 O

ANISOU 793 O PHE A 135 1480 1748 1913 -105 -434 126 O

ATOM 794 CB PHE A 135 8.703 -2. .576 -24. .910 1. .00 12. .30 C

ANISOU 794 CB PHE A 135 728 2250 1693 167 -57 370 C

ATOM 795 CG PHE A 135 9.781 -3. .457 -24. .327 1. .00 13. .50 c

ANISOU 795 CG PHE A 135 1242 2245 1641 523 -8 341 c

ATOM 796 CD1 PHE A 135 9.609 -4. .834 -24. .243 1. .00 15. .56 c

ANISOU 796 CD1 PHE A 135 1688 2318 1906 520 13 238 c

ATOM 797 CD2 PHE A 135 10.971 -2. .898 -23. .843 1. .00 13. .66 c

ANISOU 797 CD2 PHE A 135 999 2545 1642 383 231 511 c

ATOM 798 CE1 PHE A 135 10.619 -5. .651 -23. .709 1. .00 15. .22 c

ANISOU 798 CE1 PHE A 135 1185 2649 1948 474 82 183 c

ATOM 799 CE2 PHE A 135 11.965 -3. .708 -23. .296 1. .00 12. .93 c

ANISOU 799 CE2 PHE A 135 1157 2219 1535 273 91 395 c

ATOM 800 CZ PHE A 135 11.789 -5. .075 -23. .227 1. .00 14. .26 c

ANISOU 800 CZ PHE A 135 1333 2266 1818 145 372 365 c

ATOM 801 N LEU A 136 6.159 -0. .711 -25. .170 1. .00 11. .21 N

ANISOU 801 N LEU A 136 771 2154 1334 -11 112 119 N

ATOM 802 CA LEU A 136 5.602 0, .612 -25. .439 1. .00 13. .44 C

ANISOU 802 CA LEU A 136 1537 2273 1295 143 -136 87 C

ATOM 803 C LEU A 136 4.588 1. .045 -24. .377 1. .00 13. .27 c

ANISOU 803 C LEU A 136 1574 1725 1741 74 13 -175 c

ATOM 804 O LEU A 136 4.569 2, .216 -23. .955 1. .00 13. .05 0

ANISOU 804 O LEU A 136 1154 1608 2196 195 330 -153 0

ATOM 805 CB LEU A 136 4.962 0, .647 -26. .828 1. .00 12. .94 c

ANISOU 805 CB LEU A 136 1675 2170 1070 -185 -21 50 c

ATOM 806 CG LEU A 136 5.980 0. .414 -27. .955 1. .00 13. .27 c

ANISOU 806 CG LEU A 136 1483 2188 1370 33 -34 -31 c

ATOM 807 CD1 LEU A 136 5.247 0, .056 -29. .224 1. .00 15. .98 c

ANISOU 807 CD1 LEU A 136 1831 2282 1957 257 -648 -209 c

ATOM 808 CD2 LEU A 136 6.898 1. .611 -28. .185 1. .00 14. .57 c

ANISOU 808 CD2 LEU A 136 2037 2067 1430 3 375 238 c ATOM 809 N ARG A 137 3.776 0..102 -23..910 1..00 13..59 N

ANISOU 809 N ARG A 137 1445 1897 1821 -60 - 215 ^■211 N

ATOM 810 CA ARG A 137 2.752 0. .436 -22. .932 1. .00 14. .86 C

ANISOU 810 CA ARG A 137 1758 1932 1955 -72 165 140 C

ATOM 811 C ARG A 137 3.353 0. .813 -21. .566 1. .00 14. .87 C

ANISOU 811 C ARG A 137 1821 1564 2264 33 -31 -43 C

ATOM 812 O ARG A 137 2.891 1. .760 -20. .913 1. .00 13. .83 O

ANISOU 812 O ARG A 137 1444 1691 2120 68 - 122 -4 O

ATOM 813 CB ARG A 137 1.741 -0. ,711 -22. .819 1. .00 13. .98 C

ANISOU 813 CB ARG A 137 1446 1749 2115 108 -89 ^■144 C

ATOM 814 CG ARG A 137 0.889 -0. ,868 -24. .077 1. .00 14. .30 C

ANISOU 814 CG ARG A 137 1515 1725 2192 191 - 121 ^■132 C

ATOM 815 CD ARG A 137 0.147 -2. ,189 -24. .107 1. .00 14. .04 C

ANISOU 815 CD ARG A 137 1339 1954 2040 -23 - 131 76 C

ATOM 816 NE ARG A 137 -0.702 -2. ,325 -22. .915 1. .00 15. .42 N

ANISOU 816 NE ARG A 137 1089 2759 2009 -166 - 153 -76 N

ATOM 817 CZ ARG A 137 -0.623 -3. ,319 -22. .028 1. .00 16. .87 C

ANISOU 817 CZ ARG A 137 1567 2153 2690 -39 107 -45 C

ATOM 818 NH1 ARG A 137 0.223 -4. ,331 -22. .194 1. .00 21. .86 N

ANISOU 818 NH1 ARG A 137 2463 3013 2826 784 -77 107 N

ATOM 819 NH2 ARG A 137 -1.419 -3. ,316 -20. .971 1. .00 20. .23 N

ANISOU 819 NH2 ARG A 137 2269 2568 2849 446 338 745 N

ATOM 820 N LEU A 138 4.397 0. ,094 -21. .150 1. .00 14. .49 N

ANISOU 820 N LEU A 138 1499 2031 1973 -152 14 284 N

ATOM 821 CA LEU A 138 4.980 0. .289 -19. .824 1. .00 14. .82 C

ANISOU 821 CA LEU A 138 1843 1749 2037 -109 47 -79 C

ATOM 822 C LEU A 138 6.060 1. .367 -19. .754 1. .00 14. .60 C

ANISOU 822 C LEU A 138 1492 2050 2006 -24 -38 ^■117 C

ATOM 823 O LEU A 138 6.335 1. .905 -18. .685 1. .00 16. .81 O

ANISOU 823 O LEU A 138 1728 2912 1747 24 96 ^■188 O

ATOM 824 CB LEU A 138 5.483 -1. ,054 -19. .245 1. .00 15. .18 C

ANISOU 824 CB LEU A 138 1449 2082 2234 -117 72 331 C

ATOM 825 CG LEU A 138 4.367 -2. ,072 -18. .918 1. .00 16. .97 C

ANISOU 825 CG LEU A 138 1825 2201 2420 -199 310 752 C

ATOM 826 CD1 LEU A 138 4.924 -3. ,448 -18. .569 1. .00 22. .47 C

ANISOU 826 CD1 LEU A 138 2336 2447 3753 -50 - 570 578 C

ATOM 827 CD2 LEU A 138 3.492 -1. ,572 -17. .769 1. .00 22. .58 C

ANISOU 827 CD2 LEU A 138 2715 2911 2950 150 630 406 C

ATOM 828 N LEU A 139 6.663 1. .711 -20. .885 1. .00 13. .80 N

ANISOU 828 N LEU A 139 1579 1786 1877 21 - 405 113 N

ATOM 829 CA LEU A 139 7.847 2. .581 -20. .859 1. .00 13. .13 C

ANISOU 829 CA LEU A 139 1228 1881 1879 206 - 374 -18 C

ATOM 830 C LEU A 139 7.705 3. .853 -21. .710 1. .00 13. .35 C

ANISOU 830 C LEU A 139 1238 1973 1861 444 - 511 -30 C

ATOM 831 O LEU A 139 8.677 4. .575 -21. .932 1. .00 16. .07 O

ANISOU 831 O LEU A 139 1641 2020 2445 186 - 789 109 O

ATOM 832 CB LEU A 139 9.080 1. .756 -21. .243 1. .00 13. .25 C

ANISOU 832 CB LEU A 139 1524 1461 2047 331 - 412 18 C

ATOM 833 CG LEU A 139 9.454 0. .671 -20. .231 1. .00 13. .00 C

ANISOU 833 CG LEU A 139 1755 1465 1716 273 -59 39 c

ATOM 834 CD1 LEU A 139 10.493 -0. ,272 -20. .835 1. .00 16. .24 c

ANISOU 834 CD1 LEU A 139 2273 974 2921 563 - 158 7 c

ATOM 835 CD2 LEU A 139 9.946 1. .294 -18. .927 1. .00 15. .91 c

ANISOU 835 CD2 LEU A 139 2182 1899 1964 -Ill - 345 100 c

ATOM 836 N SER A 140 6.488 4. .125 -22. .190 1. .00 12. .47 N

ANISOU 836 N SER A 140 1175 1836 1724 577 - 348 7 N

ATOM 837 CA SER A 140 6.208 5. ,387 -22. .888 1. .00 13. .18 C

ANISOU 837 CA SER A 140 1537 1531 1938 170 - 498 -40 C

ATOM 838 C SER A 140 5.766 6. .452 -21. .877 1. .00 13. .90 C

ANISOU 838 C SER A 140 1816 1752 1712 35 - 573 ^■177 C

ATOM 839 O SER A 140 5.247 6. .123 -20. .811 1. .00 17. .89 O ANISOU 839 O SER A 140 2411 2499 1887 237 -166 -101 O

ATOM 840 CB SER A 140 5.102 5. .214 -23. .953 1. .00 13. .59 C

ANISOU 840 CB SER A 140 1653 1538 1970 114 -553 -77 C

ATOM 841 OG SER A 140 5.518 4. .340 -24. .995 1. .00 15. .69 O

ANISOU 841 OG SER A 140 2222 2159 1581 44 -732 -168 O

ATOM 842 N SER A 141 5.942 7. .720 -22. .242 1. .00 14. .72 N

ANISOU 842 N SER A 141 1668 1535 2389 55 -836 -408 N

ATOM 843 CA SER A 141 5.520 8. .869 -21. .430 1. .00 15. .22 C

ANISOU 843 CA SER A 141 1816 1435 2532 -163 -506 -369 C

ATOM 844 C SER A 141 3.988 8. .987 -21. .359 1. .00 17. .42 C

ANISOU 844 C SER A 141 1950 2439 2229 95 -487 -590 C

ATOM 845 O SER A 141 3.398 9. .318 -20. .324 1. .00 18. .42 O

ANISOU 845 O SER A 141 2094 2610 2294 94 -559 -981 O

ATOM 846 CB SER A 141 6.133 10. ,144 -22. .035 1. .00 20. .99 C

ANISOU 846 CB SER A 141 2582 1650 3742 -827 -254 -373 C

ATOM 847 OG SER A 141 5.631 11. .293 -21. .395 1. .00 27. .41 0

ANISOU 847 OG SER A 141 3905 2122 4388 -447 -53 -364 0

ATOM 848 N ARG A 142 3.354 8. .716 -22. .479 1. .00 17. .15 N

ANISOU 848 N ARG A 142 1512 2518 2483 182 -759 -324 N

ATOM 849 CA ARG A 142 1.920 8. .901 -22. .637 1. .00 18. .15 C

ANISOU 849 CA ARG A 142 1504 2744 2646 296 -725 -492 C

ATOM 850 C ARG A 142 1.491 8. .116 -23. .862 1. .00 16. .74 C

ANISOU 850 C ARG A 142 1537 2994 1828 218 -683 58 C

ATOM 851 O ARG A 142 2.321 7. .653 -24. .667 1. .00 18. .90 O

ANISOU 851 O ARG A 142 1422 3433 2324 299 -675 -425 O

ATOM 852 CB ARG A 142 1.528 10. .394 -22. .766 1. .00 21. .83 C

ANISOU 852 CB ARG A 142 2004 2749 3539 340 -623 -548 c

ATOM 853 CG ARG A 142 2.377 11. .222 -23. .708 1. .00 27. .22 c

ANISOU 853 CG ARG A 142 2034 4235 4071 497 -541 323 c

ATOM 854 CD ARG A 142 2.000 12. .707 -23. .731 1. .00 38. .08 c

ANISOU 854 CD ARG A 142 3322 4325 6818 315 -871 -809 c

ATOM 855 NE ARG A 142 2.136 13. ,406 -22. .445 1. .00 56. .65 N

ANISOU 855 NE ARG A 142 7384 7315 6822 -439 -686 - 1066 N

ATOM 856 CZ ARG A 142 3.289 13. .756 -21. .870 1. .00 55. .20 C

ANISOU 856 CZ ARG A 142 7333 7082 6556 -355 -672 - 1206 C

ATOM 857 NH1 ARG A 142 4.453 13. .454 -22. .432 1. .00 48. .39 N

ANISOU 857 NH1 ARG A 142 7206 4475 6704 581 -553 474 N

ATOM 858 NH2 ARG A 142 3.278 14. .400 -20. .710 1. .00 69. .33 N

ANISOU 858 NH2 ARG A 142 12429 5425 8487 1108 -790 - 2430 N

ATOM 859 N ALA A 143 0.187 7. .941 -23. .987 1. .00 16. .67 N

ANISOU 859 N ALA A 143 1534 2912 1887 137 -589 -310 N

ATOM 860 CA ALA A 143 -0.374 7. ,307 -25. .174 1. .00 15. .46 C

ANISOU 860 CA ALA A 143 1381 2611 1881 220 -679 -201 C

ATOM 861 C ALA A 143 -1.729 7. ,902 -25. .435 1. .00 14. .75 C

ANISOU 861 C ALA A 143 1661 2131 1809 477 -459 13 C

ATOM 862 O ALA A 143 -2.339 8. ,486 -24. .545 1. .00 14. .62 O

ANISOU 862 O ALA A 143 903 2604 2047 71 -390 -244 O

ATOM 863 CB ALA A 143 -0.480 5. ,798 -25. .003 1. .00 16. .63 C

ANISOU 863 CB ALA A 143 1872 2590 1857 610 -368 68 C

ATOM 864 N SER A 144 -2.180 7. ,759 -26. .670 1. .00 13. .06 N

ANISOU 864 N SER A 144 1285 1813 1864 -42 -437 62 N

ATOM 865 CA SER A 144 -3.488 8. ,233 -27. .078 1. .00 13. .21 C

ANISOU 865 CA SER A 144 1126 1849 2041 -94 -422 -246 C

ATOM 866 C SER A 144 -4.021 7. ,359 -28. .197 1. .00 12. .74 C

ANISOU 866 C SER A 144 888 2242 1710 -79 -278 -213 C

ATOM 867 O SER A 144 -3.279 6. ,726 -28. .934 1. .00 12. .47 O

ANISOU 867 O SER A 144 1029 1813 1893 43 -342 -171 O

ATOM 868 CB SER A 144 -3.460 9. ,705 -27. .514 1. .00 16. .38 C

ANISOU 868 CB SER A 144 2093 2086 2043 -142 -399 90 C

ATOM 869 OG SER A 144 -2.779 9. ,851 -28. .735 1. .00 21. .11 O

ANISOU 869 OG SER A 144 2841 2444 2736 -436 174 258 0 ATOM 870 N GLN A 145 -5.339 7..344 -28..314 1..00 11..57 N

ANISOU 870 N GLN A 145 857 2090 1449 154 -420 -104 N

ATOM 871 CA GLN A 145 -5.991 6. .587 -29. .376 1. .00 12. .54 C

ANISOU 871 CA GLN A 145 1205 1806 1752 15 -289 -291 C

ATOM 872 C GLN A 145 -7.367 7. .140 -29. .605 1. .00 13. .24 C

ANISOU 872 C GLN A 145 1270 2135 1625 172 -254 -134 C

ATOM 873 O GLN A 145 -8.079 7. .465 -28. .640 1. .00 14. .48 O

ANISOU 873 O GLN A 145 1525 2267 1708 432 -184 -233 O

ATOM 874 CB GLN A 145 -6.064 5. .100 -29. .043 1. .00 13. .18 C

ANISOU 874 CB GLN A 145 1359 1753 1895 -5 -148 -363 C

ATOM 875 CG GLN A 145 -6.601 4. .266 -30. .212 1. .00 11. .80 C

ANISOU 875 CG GLN A 145 1137 1547 1799 -99 -305 -114 C

ATOM 876 CD GLN A 145 -6.677 2. .786 -29. .900 1. .00 11. .16 C

ANISOU 876 CD GLN A 145 1001 1495 1743 -141 -383 -316 C

ATOM 877 OE1 GLN A 145 -6.421 2. .358 -28. .769 1. .00 14. .68 O

ANISOU 877 OE1 GLN A 145 1490 2341 1745 57 -306 -175 O

ATOM 878 NE2 GLN A 145 -7.038 1. .986 -30. .911 1. .00 12. .92 N

ANISOU 878 NE2 GLN A 145 1431 1486 1989 -195 -875 -300 N

ATOM 879 N GLN A 146 -7.725 7. .240 -30. .886 1. .00 11. .65 N

ANISOU 879 N GLN A 146 1040 1789 1598 275 -196 91 N

ATOM 880 CA GLN A 146 -9.076 7. .652 -31. .325 1. .00 11. .72 C

ANISOU 880 CA GLN A 146 974 1598 1881 70 -264 228 C

ATOM 881 C GLN A 146 -9.849 6. .477 -31. .874 1. .00 11. .93 C

ANISOU 881 C GLN A 146 765 1910 1855 231 -563 94 C

ATOM 882 O GLN A 146 -9.284 5. .513 -32. .391 1. .00 13. .18 O

ANISOU 882 O GLN A 146 1327 2034 1646 -107 -135 -143 O

ATOM 883 CB GLN A 146 -8.992 8. .771 -32. .363 1. .00 14. .36 C

ANISOU 883 CB GLN A 146 2041 864 2548 402 -503 203 C

ATOM 884 CG GLN A 146 -8.538 10. .103 -31. .765 1. .00 18. .86 C

ANISOU 884 CG GLN A 146 2947 1490 2726 -442 -630 67 C

ATOM 885 CD GLN A 146 -8.439 11. .238 -32. .780 1. .00 19. .55 C

ANISOU 885 CD GLN A 146 2930 2148 2348 189 189 215 C

ATOM 886 OE1 GLN A 146 -9.065 11. .211 -33. .838 1. .00 22. .20 O

ANISOU 886 OE1 GLN A 146 3390 2768 2275 298 86 704 O

ATOM 887 NE2 GLN A 146 -7.676 12. .264 -32. .431 1. .00 25. .88 N

ANISOU 887 NE2 GLN A 146 3421 2322 4089 -279 160 482 N

ATOM 888 N ILE A 147 -11.167 6. .544 -31. .735 1. .00 10. .78 N

ANISOU 888 N ILE A 147 736 1693 1668 -31 -394 113 N

ATOM 889 CA ILE A 147 -12.031 5. .517 -32. .315 1. .00 12. .11 C

ANISOU 889 CA ILE A 147 1174 1498 1927 -173 -342 89 C

ATOM 890 C ILE A 147 -13.277 6. .238 -32. .797 1. .00 12. .26 C

ANISOU 890 C ILE A 147 1112 1686 1857 -208 -349 21 C

ATOM 891 O ILE A 147 -13.753 7. .156 -32. .110 1. .00 13. .37 O

ANISOU 891 O ILE A 147 1100 2034 1946 -150 -609 -259 O

ATOM 892 CB ILE A 147 -12.330 4. .361 -31. .308 1. .00 14. .35 C

ANISOU 892 CB ILE A 147 1456 1629 2367 -642 -54 129 C

ATOM 893 CGI ILE A 147 -13.169 3. .255 -31. .953 1. .00 15. .85 C

ANISOU 893 CGI ILE A 147 2129 1886 2006 -674 -562 136 C

ATOM 894 CG2 ILE A 147 -13.017 4. .854 -30. .048 1. .00 15. .01 C

ANISOU 894 CG2 ILE A 147 1686 1801 2216 -234 -378 -13 C

ATOM 895 CD1 ILE A 147 -13.057 1. .945 -31. .187 1. .00 22. .04 C

ANISOU 895 CD1 ILE A 147 3023 1601 3748 -749 -65 415 C

ATOM 896 N THR A 148 -13.765 5. .846 -33. .982 1. .00 12. .96 N

ANISOU 896 N THR A 148 1260 1870 1794 40 -197 -265 N

ATOM 897 CA THR A 148 -14.895 6. .495 -34. .642 1. .00 14. .39 C

ANISOU 897 CA THR A 148 1389 2264 1812 -44 -256 -42 C

ATOM 898 C THR A 148 -16.040 5. .528 -34. .685 1. .00 12. .51 C

ANISOU 898 C THR A 148 1577 1804 1373 27 -215 -305 C

ATOM 899 O THR A 148 -15.904 4. .429 -35. .215 1. .00 13. .18 O

ANISOU 899 O THR A 148 1616 1648 1743 -37 31 -278 O

ATOM 900 CB THR A 148 -14.529 6. .937 -36. .066 1. .00 15. .76 C ANISOU 900 CB THR A 148 1826 2436 1723 -19 -542 -11 C

ATOM 901 OG1 THR A 148 -13.482 7. .897 -35. .981 1. .00 17. .14 O

ANISOU 901 OG1 THR A 148 1456 2378 2677 166 221 -278 O

ATOM 902 CG2 THR A 148 -15.748 7. .556 -36. .813 1. .00 16. .88 C

ANISOU 902 CG2 THR A 148 2189 2427 1797 362 -374 365 C

ATOM 903 N TYR A 149 -17.162 5. .947 -34. .099 1. .00 14. .05 N

ANISOU 903 N TYR A 149 1377 2268 1693 -11 -120 -68 N

ATOM 904 CA TYR A 149 -18.408 5. .197 -34. .161 1. .00 13. .13 C

ANISOU 904 CA TYR A 149 1331 2181 1478 0 -29 15 C

ATOM 905 C TYR A 149 -19.283 5. .737 -35. .287 1. .00 13. .41 C

ANISOU 905 C TYR A 149 1451 2160 1482 -44 -100 6 C

ATOM 906 O TYR A 149 -19.721 6. .887 -35. .249 1. .00 14. .71 O

ANISOU 906 O TYR A 149 1603 2336 1648 137 -205 -415 O

ATOM 907 CB TYR A 149 -19.133 5. .351 -32. .829 1. .00 13. .85 C

ANISOU 907 CB TYR A 149 1356 2461 1446 -25 -40 136 C

ATOM 908 CG TYR A 149 -20.405 4. .549 -32. .637 1. .00 14. .85 C

ANISOU 908 CG TYR A 149 1287 2441 1915 -19 -162 88 c

ATOM 909 CD1 TYR A 149 -20.349 3. .189 -32. .346 1. .00 15. .29 c

ANISOU 909 CD1 TYR A 149 1530 2316 1961 -6 148 -80 c

ATOM 910 CD2 TYR A 149 -21.653 5. .172 -32. .659 1. .00 15. .95 c

ANISOU 910 CD2 TYR A 149 1650 2451 1960 311 125 -143 c

ATOM 911 CE1 TYR A 149 -21.501 2. .447 -32. .118 1. .00 15. .08 c

ANISOU 911 CE1 TYR A 149 1070 2399 2259 256 -256 -28 c

ATOM 912 CE2 TYR A 149 -22.819 4. .442 -32. .439 1. .00 16. .73 c

ANISOU 912 CE2 TYR A 149 1543 2620 2193 306 -167 4 c

ATOM 913 CZ TYR A 149 -22.743 3. .085 -32. .164 1. .00 17. .23 c

ANISOU 913 CZ TYR A 149 1259 2538 2748 444 -240 -118 c

ATOM 914 OH TYR A 149 -23.884 2. .353 -31. .914 1. .00 15. .93 0

ANISOU 914 OH TYR A 149 2167 2007 1878 -1 -246 133 0

ATOM 915 N HIS A 150 -19.532 4. .898 -36. .285 1. .00 14. .55 N

ANISOU 915 N HIS A 150 1539 2382 1607 79 -435 -112 N

ATOM 916 CA HIS A 150 -20.474 5. .224 -37. .357 1. .00 15. .20 C

ANISOU 916 CA HIS A 150 1277 2730 1768 176 -437 -250 c

ATOM 917 C HIS A 150 -21.858 4. .809 -36. .911 1. .00 13. .94 c

ANISOU 917 C HIS A 150 1428 2109 1759 164 -232 -516 c

ATOM 918 O HIS A 150 -22.041 3. .698 -36. .417 1. .00 15. .77 0

ANISOU 918 O HIS A 150 1530 2316 2143 -85 -608 -332 0

ATOM 919 CB HIS A 150 -20.069 4. .525 -38. .648 1. .00 17. .42 c

ANISOU 919 CB HIS A 150 1815 2698 2106 255 -83 -339 c

ATOM 920 CG HIS A 150 -18.756 5. .010 -39. .202 1. .00 17. .35 c

ANISOU 920 CG HIS A 150 2227 2804 1559 131 -12 -44 c

ATOM 921 ND1 HIS A 150 -18.645 6. .152 -39. .897 1. .00 19. .46 N

ANISOU 921 ND1 HIS A 150 2368 3104 1921 -121 -230 218 N

ATOM 922 CD2 HIS A 150 -17.473 4. .469 -39. .125 1. .00 21. .97 C

ANISOU 922 CD2 HIS A 150 2344 3754 2248 321 151 563 C

ATOM 923 CE1 HIS A 150 -17.360 6. .341 -40. .253 1. .00 21. .50 C

ANISOU 923 CE1 HIS A 150 2486 3393 2290 392 195 -119 C

ATOM 924 NE2 HIS A 150 -16.643 5. .304 -39. .786 1. .00 20. .20 N

ANISOU 924 NE2 HIS A 150 2273 3656 1745 61 -127 265 N

ATOM 925 N CYS A 151 -22.834 5. .706 -37. .055 1. .00 13. .73 N

ANISOU 925 N CYS A 151 1104 2602 1510 203 -625 -454 N

ATOM 926 CA CYS A 151 -24.154 5. .509 -36. .444 1. .00 14. .38 C

ANISOU 926 CA CYS A 151 1259 2381 1821 -88 -492 -429 C

ATOM 927 C CYS A 151 -25.290 5. .795 -37. .412 1. .00 17. .22 C

ANISOU 927 C CYS A 151 1758 2847 1936 -5 -763 -312 C

ATOM 928 O CYS A 151 -25.276 6. .827 -38. .118 1. .00 16. .92 O

ANISOU 928 O CYS A 151 1747 2913 1766 -285 -622 -319 O

ATOM 929 CB CYS A 151 -24.324 6. .456 -35. .251 1. .00 15. .67 C

ANISOU 929 CB CYS A 151 1618 2417 1919 68 -130 -403 C

ATOM 930 SG CYS A 151 -24.148 8. .208 -35. .693 1. .00 17. .06 S

ANISOU 930 SG CYS A 151 2091 2476 1914 152 -251 -495 S ATOM 931 N LYS A 152 -26.280 4..897 -37..416 1..00 15..08 N

ANISOU 931 N LYS A 152 991 3036 1700 197 -616 -426 N

ATOM 932 CA LYS A 152 -27.584 5. .148 -38. .061 1. .00 17. .45 C

ANISOU 932 CA LYS A 152 1256 3528 1847 45 -956 -262 C

ATOM 933 C LYS A 152 -28.653 4. .813 -37. .021 1. .00 17. .08 C

ANISOU 933 C LYS A 152 1376 2922 2189 95 -661 -631 C

ATOM 934 O LYS A 152 -28.752 3. .658 -36. .569 1. .00 19. .41 O

ANISOU 934 O LYS A 152 1921 2817 2634 -206 -861 -644 O

ATOM 935 CB LYS A 152 -27.772 4. .297 -39. .324 1. .00 19. .04 C

ANISOU 935 CB LYS A 152 1625 3247 2359 203 -1270 -469 C

ATOM 936 CG LYS A 152 -29.077 4. .608 -40. .057 1. .00 22. .18 C

ANISOU 936 CG LYS A 152 1606 4481 2338 535 -1258 -922 C

ATOM 937 CD LYS A 152 -29.217 3. .753 -41. .293 1. .00 27. .91 C

ANISOU 937 CD LYS A 152 2723 5405 2477 -158 -1220 - 1349 C

ATOM 938 CE LYS A 152 -30.613 3. .847 -41. .884 1. .00 30. .85 C

ANISOU 938 CE LYS A 152 2754 4401 4563 -237 -1488 - 3081 c

ATOM 939 NZ LYS A 152 -30.856 2. .665 -42. .734 1. .00 39. .31 N

ANISOU 939 NZ LYS A 152 5885 3387 5664 -940 -1384 - 3084 N

ATOM 940 N ASN A 153 -29.428 5. .826 -36. .618 1. .00 18. .12 N

ANISOU 940 N ASN A 153 1458 2850 2573 261 -688 -403 N

ATOM 941 CA ASN A 153 -30.428 5. .661 -35. .556 1. .00 17. .90 C

ANISOU 941 CA ASN A 153 1735 2600 2464 -150 -647 -453 C

ATOM 942 C ASN A 153 -29.836 5. .060 -34. .295 1. .00 17. .88 C

ANISOU 942 C ASN A 153 1707 2477 2607 -145 -722 -419 C

ATOM 943 O ASN A 153 -30.407 4. .136 -33. .709 1. .00 17. .78 O

ANISOU 943 O ASN A 153 1410 2344 2998 66 -517 -448 O

ATOM 944 CB ASN A 153 -31.586 4. .788 -36. .057 1. .00 19. .51 C

ANISOU 944 CB ASN A 153 1958 2790 2663 -246 -1034 -318 C

ATOM 945 CG ASN A 153 -32.300 5. .407 -37. .242 1. .00 23. .79 C

ANISOU 945 CG ASN A 153 2520 3564 2954 331 -1330 -298 C

ATOM 946 OD1 ASN A 153 -32.514 6. .627 -37. .285 1. .00 24. .31 O

ANISOU 946 OD1 ASN A 153 2113 3670 3453 289 -778 -181 O

ATOM 947 ND2 ASN A 153 -32.643 4. .575 -38. .234 1. .00 26. .91 N

ANISOU 947 ND2 ASN A 153 2767 3804 3653 -465 -1076 -607 N

ATOM 948 N SER A 154 -28.692 5. .593 -33. .870 1. .00 17. .05 N

ANISOU 948 N SER A 154 1488 2736 2251 -148 -395 -461 N

ATOM 949 CA SER A 154 -27.963 5. .047 -32. .731 1. .00 14. .76 C

ANISOU 949 CA SER A 154 1520 1843 2243 -21 -359 -560 C

ATOM 950 C SER A 154 -27.212 6. .168 -32. .041 1. .00 14. .07 C

ANISOU 950 C SER A 154 1167 2139 2038 -528 -293 -112 C

ATOM 951 O SER A 154 -26.278 6. .718 -32. .613 1. .00 15. .46 O

ANISOU 951 O SER A 154 1490 2655 1726 -620 39 -113 O

ATOM 952 CB SER A 154 -26.958 3. .963 -33. .190 1. .00 16. .26 C

ANISOU 952 CB SER A 154 1213 2420 2544 340 -549 -409 C

ATOM 953 OG SER A 154 -26.264 3. .420 -32. .067 1. .00 15. .74 O

ANISOU 953 OG SER A 154 1298 2389 2291 195 -394 -432 O

ATOM 954 N ILE A 155 -27.624 6. .503 -30. .819 1. .00 14. .32 N

ANISOU 954 N ILE A 155 1183 2127 2130 -298 -449 -322 N

ATOM 955 CA ILE A 155 -26.934 7. .512 -30. .012 1. .00 14. .26 C

ANISOU 955 CA ILE A 155 1489 2114 1813 -277 -246 -417 C

ATOM 956 C ILE A 155 -25.594 6. .917 -29. .590 1. .00 14. .56 C

ANISOU 956 C ILE A 155 1564 1944 2020 -336 -303 -330 C

ATOM 957 O ILE A 155 -25.536 5. .749 -29. .209 1. .00 15. .80 O

ANISOU 957 O ILE A 155 1647 2163 2193 -559 -380 -246 O

ATOM 958 CB ILE A 155 -27.719 7. .849 -28. .723 1. .00 16. .14 C

ANISOU 958 CB ILE A 155 2086 2102 1942 -50 -103 -569 C

ATOM 959 CGI ILE A 155 -29.145 8. .376 -28. .999 1. .00 22. .34 c

ANISOU 959 CGI ILE A 155 2674 3223 2589 667 -459 -291 c

ATOM 960 CG2 ILE A 155 -26.916 8. .777 -27. .828 1. .00 14. .30 c

ANISOU 960 CG2 ILE A 155 1403 1933 2094 -98 -410 -59 c

ATOM 961 CD1 ILE A 155 -29.312 9. .315 -30. .169 1. .00 24. .44 c ANISOU 961 CD1 ILE A 155 2651 3290 3343 97 400 285 C

ATOM 962 N ALA A 156 -24.537 7. ,733 -29. .641 1. .00 13. .90 N

ANISOU 962 N ALA A 156 1209 2179 1892 -231 36 323 N

ATOM 963 CA ALA A 156 -23.181 7. ,313 -29. .302 1. .00 13. .13 C

ANISOU 963 CA ALA A 156 1482 2186 1318 -92 22 244 C

ATOM 964 C ALA A 156 -22.678 7. ,953 -28. .009 1. .00 12. .53 C

ANISOU 964 C ALA A 156 1401 1954 1405 -295 0 146 C

ATOM 965 O ALA A 156 -21.922 7. ,337 -27. .250 1. .00 13. .31 O

ANISOU 965 O ALA A 156 1620 2319 1116 -407 -33 77 O

ATOM 966 CB ALA A 156 -22.246 7. ,675 -30. .442 1. .00 14. .45 C

ANISOU 966 CB ALA A 156 1468 2513 1509 -7 213 234 C

ATOM 967 N TYR A 157 -23.090 9. ,197 -27. .771 1. .00 11. .61 N

ANISOU 967 N TYR A 157 1119 1809 1483 -466 45 191 N

ATOM 968 CA TYR A 157 -22.641 9. ,931 -26. .599 1. .00 12. .11 C

ANISOU 968 CA TYR A 157 1345 1819 1435 -321 46 247 C

ATOM 969 C TYR A 157 -23.807 10. ,755 -26. .057 1. .00 13. .14 C

ANISOU 969 C TYR A 157 1301 2254 1437 6 - 182 165 C

ATOM 970 O TYR A 157 -24.523 10. ,303 -25. .158 1. .00 14. .47 O

ANISOU 970 O TYR A 157 1656 2060 1780 0 137 224 O

ATOM 971 CB TYR A 157 -21.421 10. ,805 -26. .958 1. .00 12. .27 C

ANISOU 971 CB TYR A 157 896 2101 1662 -191 37 340 C

ATOM 972 CG TYR A 157 -20.901 11. ,667 -25. .809 1. .00 10. .61 c

ANISOU 972 CG TYR A 157 528 1982 1522 -387 202 157 c

ATOM 973 CD1 TYR A 157 -20.380 11. ,088 -24. .648 1. .00 12. .85 c

ANISOU 973 CD1 TYR A 157 797 2399 1686 -284 70 -42 c

ATOM 974 CD2 TYR A 157 -20.941 13. ,064 -25. .889 1. .00 12. .34 c

ANISOU 974 CD2 TYR A 157 902 1982 1803 -334 161 162 c

ATOM 975 CE1 TYR A 157 -19.895 11. ,888 -23. .608 1. .00 14. .25 c

ANISOU 975 CE1 TYR A 157 1423 1901 2088 - 628 -72 73 c

ATOM 976 CE2 TYR A 157 -20.490 13. ,863 -24. .849 1. .00 13. .46 c

ANISOU 976 CE2 TYR A 157 1243 1929 1942 -464 - 181 19 c

ATOM 977 CZ TYR A 157 -19.956 13. ,271 -23. .716 1. .00 14. .19 c

ANISOU 977 CZ TYR A 157 1393 1975 2021 -413 24 190 c

ATOM 978 OH TYR A 157 -19.505 14. ,072 -22. .686 1. .00 16. .88 0

ANISOU 978 OH TYR A 157 1487 2640 2286 -604 - 231 108 0

ATOM 979 N MET A 158 -24.023 11. ,941 -26. .624 1. .00 13. .42 N

ANISOU 979 N MET A 158 1054 2110 1935 108 -99 248 N

ATOM 980 CA MET A 158 -25.147 12. ,799 -26. .214 1. .00 13. .60 C

ANISOU 980 CA MET A 158 1154 1809 2205 146 - 230 264 c

ATOM 981 C MET A 158 -26.453 12. ,374 -26. .897 1. .00 15. .30 c

ANISOU 981 C MET A 158 1444 2209 2159 -300 -96 683 c

ATOM 982 O MET A 158 -26.461 12. ,069 -28. .097 1. .00 15. .59 0

ANISOU 982 O MET A 158 1612 2446 1863 -235 - 117 134 0

ATOM 983 CB MET A 158 -24.832 14. ,268 -26. .542 1. .00 15. .51 c

ANISOU 983 CB MET A 158 1482 1903 2505 -257 - 234 361 c

ATOM 984 CG MET A 158 -25.931 15. ,264 -26. .205 1. .00 19. .90 c

ANISOU 984 CG MET A 158 1574 2608 3377 -109 - 167 823 c

ATOM 985 SD MET A 158 -26.038 15. ,562 -24. .429 1. .00 25. .43 s

ANISOU 985 SD MET A 158 2581 3454 3625 49 -93 924 s

ATOM 986 CE MET A 158 -24.480 16. ,419 -24. .171 1. .00 23. .66 c

ANISOU 986 CE MET A 158 2442 3277 3267 220 -2 980 c

ATOM 987 N ASP A 159 -27.541 12. ,355 -26. .128 1. .00 15. .73 N

ANISOU 987 N ASP A 159 1283 2405 2287 -446 -60 351 N

ATOM 988 CA ASP A 159 -28.900 12. ,116 -26. .644 1. .00 17. .55 C

ANISOU 988 CA ASP A 159 1262 2807 2597 -257 - 180 -66 C

ATOM 989 C ASP A 159 -29.559 13. ,497 -26. .730 1. .00 19. .09 c

ANISOU 989 C ASP A 159 1815 3253 2186 122 - 174 570 c

ATOM 990 O ASP A 159 -29.877 14. ,103 -25. .711 1. .00 21. .26 0

ANISOU 990 O ASP A 159 1952 3374 2752 371 212 137 0

ATOM 991 CB ASP A 159 -29.655 11. ,194 -25. .660 1. .00 20. .00 c

ANISOU 991 CB ASP A 159 1613 3463 2523 -91 179 130 c ATOM 992 CG ASP A 159 -31.066 10.,816 -26..121 1..00 25..09 C

ANISOU 992 CG ASP A 159 1832 4576 3125 -597 69 422 C

ATOM 993 OD1 ASP A 159 -31.570 11. ,315 -27. .137 1. .00 30. .02 O

ANISOU 993 OD1 ASP A 159 1609 6205 3590 -1481 - 758 967 O

ATOM 994 OD2 ASP A 159 -31.704 10. ,006 -25. .419 1. .00 31. .04 O

ANISOU 994 OD2 ASP A 159 2136 4193 5464 -1097 154 656 O

ATOM 995 N GLN A 160 -29.744 14. ,019 -27. .934 1. .00 16. .97 N

ANISOU 995 N GLN A 160 1446 2725 2277 739 163 679 N

ATOM 996 CA GLN A 160 -30.256 15. ,391 -28. .062 1. .00 20. .51 C

ANISOU 996 CA GLN A 160 1701 2892 3198 1151 514 425 C

ATOM 997 C GLN A 160 -31.634 15. ,618 -27. .398 1. .00 20. .40 C

ANISOU 997 C GLN A 160 1947 3263 2538 1383 472 251 C

ATOM 998 O GLN A 160 -31.866 16. ,669 -26. .796 1. .00 26. .37 O

ANISOU 998 O GLN A 160 2932 3362 3724 1669 299 41 O

ATOM 999 CB GLN A 160 -30.288 15. ,824 -29. .522 1. .00 27. .61 C

ANISOU 999 CB GLN A 160 3260 4145 3082 505 360 352 C

ATOM 1000 CG GLN A 160 -30.277 17. ,336 -29. .704 1. .00 34. .49 c

ANISOU 1000 CG GLN A 160 4982 4344 3777 780 240 474 c

ATOM 1001 CD GLN A 160 -31.322 17. ,805 -30. .681 1. .00 46. .54 c

ANISOU 1001 CD GLN A 160 6444 5153 6086 1166 - 864 1151 c

ATOM 1002 OE1 GLN A 160 -32.521 17. ,745 -30. .397 1. .00 52. .34 0

ANISOU 1002 OE1 GLN A 160 6745 6332 6811 1096 73 459 0

ATOM 1003 NE2 GLN A 160 -30.879 18. ,282 -31. .841 1. .00 51. .64 N

ANISOU 1003 NE2 GLN A 160 7670 6206 5744 1070 7 625 N

ATOM 1004 N ALA A 161 -32.519 14. ,630 -27. .497 1. .00 24. .91 N

ANISOU 1004 N ALA A 161 1945 4345 3175 893 408 -205 N

ATOM 1005 CA ALA A 161 -33.877 14. ,743 -26. .947 1. .00 28. .69 C

ANISOU 1005 CA ALA A 161 2369 5086 3443 497 886 -467 C

ATOM 1006 C ALA A 161 -33.872 14. ,846 -25. .423 1. .00 24. .19 C

ANISOU 1006 C ALA A 161 1870 3764 3556 2024 372 - 1306 C

ATOM 1007 O ALA A 161 -34.552 15. ,688 -24. .865 1. .00 27. .28 O

ANISOU 1007 O ALA A 161 2292 4750 3323 2081 473 - 1370 O

ATOM 1008 CB ALA A 161 -34.740 13. ,574 -27. .399 1. .00 33. .91 C

ANISOU 1008 CB ALA A 161 2949 6242 3692 24 58 - 1292 C

ATOM 1009 N SER A 162 -33.097 13. ,989 -24. .760 1. .00 22. .23 N

ANISOU 1009 N SER A 162 1729 4208 2505 617 115 -378 N

ATOM 1010 CA SER A 162 -33.015 13. ,996 -23. .301 1. .00 20. .89 C

ANISOU 1010 CA SER A 162 1541 3873 2523 34 - 226 -687 C

ATOM 1011 C SER A 162 -32.025 15. ,035 -22. .771 1. .00 19. .88 C

ANISOU 1011 C SER A 162 1815 3516 2223 -150 64 -524 C

ATOM 1012 O SER A 162 -32.168 15. ,498 -21. .649 1. .00 20. .66 O

ANISOU 1012 O SER A 162 2054 3225 2569 -148 62 -833 O

ATOM 1013 CB SER A 162 -32.632 12. ,613 -22. .792 1. .00 23. .07 C

ANISOU 1013 CB SER A 162 2121 4338 2304 553 339 -209 C

ATOM 1014 OG SER A 162 -31.286 12. ,346 -23. .136 1. .00 19. .84 0

ANISOU 1014 OG SER A 162 1607 3223 2707 -420 74 -214 0

ATOM 1015 N GLY A 163 -31.031 15. ,403 -23. .576 1. .00 17. .41 N

ANISOU 1015 N GLY A 163 1748 2524 2341 -472 - 211 -596 N

ATOM 1016 CA GLY A 163 -30.032 16. ,371 -23. .145 1. .00 16. .68 C

ANISOU 1016 CA GLY A 163 1493 2201 2642 -352 - 235 -280 C

ATOM 1017 C GLY A 163 -28.939 15. ,762 -22. .281 1. .00 17. .23 C

ANISOU 1017 C GLY A 163 2091 2042 2413 -175 - 310 -165 C

ATOM 1018 O GLY A 163 -28.168 16. ,485 -21. .674 1. .00 22. .18 O

ANISOU 1018 O GLY A 163 2488 2334 3604 -290 - 603 -465 O

ATOM 1019 N ASN A 164 -28.862 14. ,436 -22. .212 1. .00 15. .49 N

ANISOU 1019 N ASN A 164 1688 2080 2117 39 - Ill -384 N

ATOM 1020 CA ASN A 164 -27.855 13. ,781 -21. .373 1. .00 13. .96 C

ANISOU 1020 CA ASN A 164 1494 1999 1809 -90 70 -356 C

ATOM 1021 C ASN A 164 -27.030 12. ,703 -22. .093 1. .00 14. .52 C

ANISOU 1021 C ASN A 164 1523 2011 1982 -98 135 -393 C

ATOM 1022 O ASN A 164 -27.324 12. ,360 -23. .242 1. .00 15. .27 O ANISOU 1022 O ASN A 164 1264 2513 2023 201 177 -578 O

ATOM 1023 CB ASN A 164 -28.481 13 240 -20.080 1 00 14.08 C

ANISOU 1023 CB ASN A 164 1697 1795 1856 -240 212 -479 C

ATOM 1024 CG ASN A 164 -29.411 12 074 -20.322 1 00 16.04 C

ANISOU 1024 CG ASN A 164 1604 2235 2254 -426 394 -638 C

ATOM 1025 OD1 ASN A 164 -29.044 11 106 -21.001 1 00 16.21 O

ANISOU 1025 OD1 ASN A 164 1800 2184 2172 -386 559 -529 O

ATOM 1026 ND2 ASN A 164 -30.614 12 143 -19.752 1 00 17.29 N

ANISOU 1026 ND2 ASN A 164 1455 2866 2246 -194 268 -170 N

ATOM 1027 N VAL A 165 -25.993 12 199 -21.413 1 00 14.43 N

ANISOU 1027 N VAL A 165 1720 2019 1742 -128 0 -327 N

ATOM 1028 CA VAL A 165 -25.087 11 179 -21.969 1 00 14.84 C

ANISOU 1028 CA VAL A 165 1534 2050 2052 -308 -34 -521 C

ATOM 1029 C VAL A 165 -25.305 9 806 -21.332 1 00 16.21 C

ANISOU 1029 C VAL A 165 1451 2397 2307 -385 258 -197 C

ATOM 1030 O VAL A 165 -24.407 8 954 -21.305 1 00 17.32 O

ANISOU 1030 O VAL A 165 1746 2594 2237 -208 187 -23 O

ATOM 1031 CB VAL A 165 -23.605 11 622 -21.883 1 00 13.27 C

ANISOU 1031 CB VAL A 165 1490 1847 1703 -251 130 72 C

ATOM 1032 CGI VAL A 165 -23.406 12 905 -22.696 1 00 15.38 C

ANISOU 1032 CGI VAL A 165 1873 1491 2479 -260 38 65 C

ATOM 1033 CG2 VAL A 165 -23.187 11 855 -20.433 1 00 16.49 C

ANISOU 1033 CG2 VAL A 165 2069 2244 1954 -375 -186 -203 C

ATOM 1034 N LYS A 166 -26.525 9 571 -20.847 1 00 16.16 N

ANISOU 1034 N LYS A 166 1687 2060 2390 -290 670 -367 N

ATOM 1035 CA LYS A 166 -26.840 8 310 -20.170 1 00 17.04 C

ANISOU 1035 CA LYS A 166 1937 2244 2291 -128 700 -176 C

ATOM 1036 C LYS A 166 -26.741 7 092 -21.078 1 00 16.04 C

ANISOU 1036 C LYS A 166 1783 2107 2204 -108 348 -141 C

ATOM 1037 O LYS A 166 -26.470 5 983 -20.603 1 00 17.73 O

ANISOU 1037 O LYS A 166 2006 2245 2484 346 1104 -127 O

ATOM 1038 CB LYS A 166 -28.222 8 376 -19.502 1 00 18.81 C

ANISOU 1038 CB LYS A 166 2399 2100 2648 9 1287 -210 C

ATOM 1039 CG LYS A 166 -28.247 9 334 -18.327 1 00 21.41 C

ANISOU 1039 CG LYS A 166 2865 2679 2588 -70 1216 -318 C

ATOM 1040 CD LYS A 166 -29.572 9 292 -17.601 1 00 25.80 C

ANISOU 1040 CD LYS A 166 3149 2850 3802 -675 1777 37 C

ATOM 1041 CE LYS A 166 -29.451 10 045 -16.284 1 00 36.09 C

ANISOU 1041 CE LYS A 166 5032 4538 4140 -501 1583 -587 C

ATOM 1042 NZ LYS A 166 -30.761 10 216 -15.596 1 00 40.29 N

ANISOU 1042 NZ LYS A 166 4306 5998 5005 -1536 1411 102 N

ATOM 1043 N LYS A 167 -26.959 7 312 -22.373 1 00 14.79 N

ANISOU 1043 N LYS A 167 1690 1950 1976 -221 467 -510 N

ATOM 1044 CA LYS A 167 -26.914 6 254 -23.394 1 00 13.62 C

ANISOU 1044 CA LYS A 167 1030 2108 2034 68 -66 -619 C

ATOM 1045 C LYS A 167 -25.527 6 122 -24.031 1 00 13.19 C

ANISOU 1045 C LYS A 167 1256 1932 1823 -270 255 -327 C

ATOM 1046 O LYS A 167 -25.376 5 399 -25.017 1 00 14.35 O

ANISOU 1046 O LYS A 167 1317 2118 2015 -32 57 -466 O

ATOM 1047 CB LYS A 167 -27.934 6 508 -24.512 1 00 16.45 C

ANISOU 1047 CB LYS A 167 1591 2627 2032 -217 -301 -266 C

ATOM 1048 CG LYS A 167 -29.370 6 571 -24.032 1 00 19.20 C

ANISOU 1048 CG LYS A 167 1324 3237 2732 134 -553 -574 C

ATOM 1049 CD LYS A 167 -30.350 6 734 -25.207 1 00 24.34 C

ANISOU 1049 CD LYS A 167 2330 3204 3714 1069 -1442 -777 C

ATOM 1050 CE LYS A 167 -31.731 7 158 -24.737 1 00 29.93 C

ANISOU 1050 CE LYS A 167 2776 3972 4621 201 101 -724 C

ATOM 1051 NZ LYS A 167 -32.591 6 017 -24.338 1 00 37.81 N

ANISOU 1051 NZ LYS A 167 4603 4306 5455 -401 5 -434 N

ATOM 1052 N ALA A 168 -24.527 6 829 -23.498 1 00 12.78 N

ANISOU 1052 N ALA A 168 1303 2053 1498 -138 -24 -124 N ATOM 1053 CA ALA A 168 -23.208 6..865 -24..158 1..00 14..02 C

ANISOU 1053 CA ALA A 168 1169 2052 2106 -286 -65 -317 C

ATOM 1054 C ALA A 168 -22.559 5. .478 -24. .165 1. .00 13. .01 C

ANISOU 1054 C ALA A 168 1411 1877 1653 -330 118 -115 C

ATOM 1055 O ALA A 168 -22.734 4. .697 -23. .222 1. .00 14. .49 O

ANISOU 1055 O ALA A 168 1516 2222 1766 -59 -1 232 O

ATOM 1056 CB ALA A 168 -22.285 7. .885 -23. .496 1. .00 14. .01 C

ANISOU 1056 CB ALA A 168 1389 1953 1980 -441 46 -261 C

ATOM 1057 N LEU A 169 -21.828 5. .174 -25. .233 1. .00 13. .03 N

ANISOU 1057 N LEU A 169 1396 2067 1486 -488 172 94 N

ATOM 1058 CA LEU A 169 -21.138 3. .892 -25. .360 1. .00 12. .80 C

ANISOU 1058 CA LEU A 169 1408 2133 1322 -289 58 277 C

ATOM 1059 C LEU A 169 -19.917 3. .827 -24. .433 1. .00 12. .90 C

ANISOU 1059 C LEU A 169 1342 2057 1502 -183 38 182 C

ATOM 1060 O LEU A 169 -19.480 4. .849 -23. .882 1. .00 13. .34 O

ANISOU 1060 O LEU A 169 1122 2206 1738 -97 200 -80 O

ATOM 1061 CB LEU A 169 -20.731 3. .622 -26. .821 1. .00 12. .23 C

ANISOU 1061 CB LEU A 169 1542 1727 1378 -641 -13 -71 C

ATOM 1062 CG LEU A 169 -19.760 4. .571 -27. .559 1. .00 12. .44 c

ANISOU 1062 CG LEU A 169 1267 2119 1338 -364 104 200 c

ATOM 1063 CD1 LEU A 169 -18.320 4. .368 -27. .096 1. .00 13. .12 c

ANISOU 1063 CD1 LEU A 169 1156 1978 1849 -454 163 18 c

ATOM 1064 CD2 LEU A 169 -19.850 4. .314 -29. .047 1. .00 14. .52 c

ANISOU 1064 CD2 LEU A 169 1559 2495 1460 -168 60 -119 c

ATOM 1065 N LYS A 170 -19.401 2. .618 -24. .252 1. .00 13. .00 N

ANISOU 1065 N LYS A 170 1263 2373 1301 213 27 328 N

ATOM 1066 CA LYS A 170 -18.185 2. .389 -23. .442 1. .00 12. .85 C

ANISOU 1066 CA LYS A 170 1210 2262 1409 257 7 225 C

ATOM 1067 C LYS A 170 -17.094 1. .782 -24. .308 1. .00 13. .66 C

ANISOU 1067 C LYS A 170 1338 2265 1586 45 365 337 C

ATOM 1068 O LYS A 170 -17.375 1. .189 -25. .350 1. .00 15. .46 O

ANISOU 1068 O LYS A 170 1708 2201 1965 -131 168 152 0

ATOM 1069 CB LYS A 170 -18.469 1. .429 -22. .278 1. .00 15. .20 c

ANISOU 1069 CB LYS A 170 1332 2852 1588 425 341 524 c

ATOM 1070 CG LYS A 170 -19.591 1. .886 -21. .327 1. .00 17. .61 c

ANISOU 1070 CG LYS A 170 1687 3111 1892 168 772 539 c

ATOM 1071 CD LYS A 170 -19.598 1. .076 -20. .033 1. .00 22. .23 c

ANISOU 1071 CD LYS A 170 2976 2959 2509 -305 297 1017 c

ATOM 1072 CE LYS A 170 -19.789 -0. .416 -20. .282 1. .00 23. .45 c

ANISOU 1072 CE LYS A 170 3125 2982 2800 -314 - 485 829 c

ATOM 1073 NZ LYS A 170 -19.843 -1. .175 -18. .995 1. .00 26. .18 N

ANISOU 1073 NZ LYS A 170 3722 2653 3572 -932 - 150 1254 N

ATOM 1074 N LEU A 171 -15.847 1. .904 -23. .851 1. .00 13. .14 N

ANISOU 1074 N LEU A 171 1326 1910 1755 214 335 81 N

ATOM 1075 CA LEU A 171 -14.707 1. .318 -24. .556 1. .00 11. .69 C

ANISOU 1075 CA LEU A 171 1166 1462 1814 185 257 227 C

ATOM 1076 C LEU A 171 -13.953 0. .475 -23. .544 1. .00 13. .08 C

ANISOU 1076 C LEU A 171 1702 1409 1855 315 355 362 C

ATOM 1077 O LEU A 171 -13.986 0. .777 -22. .353 1. .00 14. .98 O

ANISOU 1077 O LEU A 171 1589 2283 1817 485 51 300 O

ATOM 1078 CB LEU A 171 -13.778 2. .421 -25. .098 1. .00 12. .86 C

ANISOU 1078 CB LEU A 171 1148 1929 1808 131 393 461 C

ATOM 1079 CG LEU A 171 -14.366 3. .493 -26. .020 1. .00 14. .54 C

ANISOU 1079 CG LEU A 171 1651 2245 1629 88 348 618 C

ATOM 1080 CD1 LEU A 171 -13.373 4. .629 -26. .267 1. .00 15. .67 c

ANISOU 1080 CD1 LEU A 171 1936 1765 2252 346 526 691 c

ATOM 1081 CD2 LEU A 171 -14.804 2. .857 -27. .329 1. .00 15. .77 c

ANISOU 1081 CD2 LEU A 171 2072 1912 2008 -236 -69 535 c

ATOM 1082 N AMET A 172 -13.275 -0. .568 -24. .024 0. .50 12. .64 N

ANISOU 1082 N AMET A 172 1231 1587 1981 261 548 361 N

ATOM 1083 CA AMET A 172 -12.452 -1. .428 -23. .174 0. .50 14. .97 C ANISOU 1083 CA AMET A 172 1612 2031 2042 132 128 481 C

ATOM 1084 C AMET A 172 -10.977 -1. .178 -23. .459 0. .50 15. .70 C

ANISOU 1084 C AMET A 172 1506 2125 2332 2 - 277 458 C

ATOM 1085 O AMET A 172 -10.548 -1. .208 -24. .615 0. .50 15. .74 O

ANISOU 1085 O AMET A 172 1628 2043 2309 157 - 362 337 O

ATOM 1086 CB AMET A 172 -12.773 -2. .899 -23. .433 0. .50 16. .46 C

ANISOU 1086 CB AMET A 172 1827 2017 2408 49 127 656 C

ATOM 1087 CG AMET A 172 -12.092 -3. .866 -22. .480 0. .50 16. .41 C

ANISOU 1087 CG AMET A 172 1351 2450 2433 33 193 812 C

ATOM 1088 SD AMET A 172 -12.537 -5. .576 -22. .823 0. .50 22. .15 S

ANISOU 1088 SD AMET A 172 2069 2489 3857 -18 -22 838 S

ATOM 1089 CE AMET A 172 -14.308 -5. .520 -22. .561 0. .50 20. .72 C

ANISOU 1089 CE AMET A 172 2239 2413 3219 -609 669 625 C

ATOM 1090 N BMET A 172 -13.281 -0. .575 -24. .020 0. .50 12. .90 N

ANISOU 1090 N BMET A 172 1290 1563 2046 276 544 362 N

ATOM 1091 CA BMET A 172 -12.458 -1. .438 -23. .167 0. .50 15. .50 C

ANISOU 1091 CA BMET A 172 1710 2036 2141 135 108 530 C

ATOM 1092 C BMET A 172 -10.981 -1. .187 -23. .456 0. .50 16. .04 C

ANISOU 1092 C BMET A 172 1583 2144 2364 14 - 326 469 C

ATOM 1093 O BMET A 172 -10.556 -1. .214 -24. .613 0. .50 16. .08 O

ANISOU 1093 O BMET A 172 1661 2084 2364 157 - 382 353 O

ATOM 1094 CB BMET A 172 -12.790 -2. .914 -23. .412 0. .50 17. .69 C

ANISOU 1094 CB BMET A 172 2173 1998 2546 73 56 754 C

ATOM 1095 CG BMET A 172 -12.081 -3. .889 -22. .483 0. .50 19. .39 c

ANISOU 1095 CG BMET A 172 2051 2279 3036 -50 -25 1121 c

ATOM 1096 SD BMET A 172 -12.466 -3. .615 -20. .742 0. .50 27. .05 s

ANISOU 1096 SD BMET A 172 3866 3447 2964 117 121 1591 s

ATOM 1097 CE BMET A 172 -13.966 -4. .578 -20. .552 0. .50 28. .48 c

ANISOU 1097 CE BMET A 172 3440 3167 4214 517 94 1257 c

ATOM 1098 N GLY A 173 -10.215 -0. .932 -22. .398 1. .00 15. .34 N

ANISOU 1098 N GLY A 173 1590 2203 2033 -45 - 169 571 N

ATOM 1099 CA GLY A 173 -8.764 -0. .784 -22. .495 1. .00 17. .53 C

ANISOU 1099 CA GLY A 173 1495 2714 2451 -19 - 421 95 C

ATOM 1100 C GLY A 173 -8.022 -2. .106 -22. .337 1. .00 18. .06 C

ANISOU 1100 C GLY A 173 1550 2671 2637 0 - 364 -354 C

ATOM 1101 O GLY A 173 -8.622 -3. .180 -22. .330 1. .00 16. .38 O

ANISOU 1101 O GLY A 173 872 2799 2550 99 - 355 150 0

ATOM 1102 N SER A 174 -6.703 -2. .018 -22. .202 1. .00 18. .09 N

ANISOU 1102 N SER A 174 1269 3380 2223 438 347 -246 N

ATOM 1103 CA SER A 174 -5.836 -3. .193 -22. .217 1. .00 21. .31 C

ANISOU 1103 CA SER A 174 2126 3028 2940 389 224 300 C

ATOM 1104 C SER A 174 -5.408 -3. .637 -20. .822 1. .00 24. .62 C

ANISOU 1104 C SER A 174 2641 3617 3093 249 198 663 C

ATOM 1105 O SER A 174 -4.594 -4. .557 -20. .673 1. .00 28. .88 O

ANISOU 1105 O SER A 174 2983 4054 3933 536 360 1137 O

ATOM 1106 CB SER A 174 -4.599 -2. .915 -23. .080 1. .00 17. .56 C

ANISOU 1106 CB SER A 174 1517 3141 2013 569 - 317 47 c

ATOM 1107 OG SER A 174 -4.890 -3. .075 -24. .459 1. .00 17. .78 0

ANISOU 1107 OG SER A 174 1437 3455 1861 616 - 210 517 0

ATOM 1108 N ASN A 175 -5.957 -2. .980 -19. .807 1. .00 25. .02 N

ANISOU 1108 N ASN A 175 2764 3925 2816 582 297 1063 N

ATOM 1109 CA ASN A 175 -5.610 -3. .264 -18. .424 1. .00 30. .16 C

ANISOU 1109 CA ASN A 175 3855 4729 2873 552 611 1379 C

ATOM 1110 C ASN A 175 -6.882 -3. .598 -17. .629 1. .00 31. .62 C

ANISOU 1110 C ASN A 175 3626 4621 3767 197 636 1027 C

ATOM 1111 O ASN A 175 -7.023 -3. .221 -16. .465 1. .00 30. .26 O

ANISOU 1111 O ASN A 175 3368 4460 3668 913 315 1334 O

ATOM 1112 CB ASN A 175 -4.869 -2. .055 -17. .845 1. .00 30. .80 c

ANISOU 1112 CB ASN A 175 3443 5250 3009 323 642 1327 c

ATOM 1113 CG ASN A 175 -3.985 -2. .409 -16. .675 1. .00 33. .67 c

ANISOU 1113 CG ASN A 175 2784 5592 4416 942 172 1033 c ATOM 1114 OD1 ASN A 175 -3.904 -1 653 -15.708 1.00 40.53 O

ANISOU 1114 OD1 ASN A 175 4063 7295 4041 -60 1357 561 O

ATOM 1115 ND2 ASN A 175 -3.304 -3 552 -16.756 1.00 35.82 N

ANISOU 1115 ND2 ASN A 175 2755 6054 4801 1741 -29 2020 N

ATOM 1116 N GLU A 176 -7.804 -4 301 -18.289 1.00 30.81 N

ANISOU 1116 N GLU A 176 3106 3951 4646 107 1216 536 N

ATOM 1117 CA GLU A 176 -9.091 -4 726 -17.706 1.00 28.14 C

ANISOU 1117 CA GLU A 176 3214 3294 4183 250 1262 651 C

ATOM 1118 C GLU A 176 -9.986 -3 549 -17.259 1.00 27.06 C

ANISOU 1118 C GLU A 176 2359 3730 4193 207 1404 791 C

ATOM 1119 O GLU A 176 -10.949 -3 730 -16.489 1.00 32.05 O

ANISOU 1119 O GLU A 176 2557 4529 5089 230 1951 301 O

ATOM 1120 CB GLU A 176 -8.870 -5 738 -16.568 1.00 30.02 C

ANISOU 1120 CB GLU A 176 3677 3576 4152 -133 944 654 C

ATOM 1121 N GLY A 177 -9.687 -2 351 -17.760 1.00 23.32 N

ANISOU 1121 N GLY A 177 2411 3319 3129 1051 639 695 N

ATOM 1122 CA GLY A 177 -10.448 -1 155 -17.399 1.00 22.52 C

ANISOU 1122 CA GLY A 177 2775 3388 2391 1202 -220 284 C

ATOM 1123 C GLY A 177 -11.306 -0 696 -18.557 1.00 21.98 C

ANISOU 1123 C GLY A 177 2322 3707 2323 1100 86 515 C

ATOM 1124 O GLY A 177 -11.067 -1 060 -19.705 1.00 28.86 O

ANISOU 1124 O GLY A 177 3206 5254 2504 1819 385 327 O

ATOM 1125 N GLU A 178 -12.308 0 105 -18.253 1.00 18.60 N

ANISOU 1125 N GLU A 178 1946 3090 2030 711 -360 123 N

ATOM 1126 CA GLU A 178 -13.232 0 606 -19.257 1.00 17.18 C

ANISOU 1126 CA GLU A 178 1786 2915 1823 126 -53 651 C

ATOM 1127 C GLU A 178 -13.127 2 116 -19.266 1.00 15.89 C

ANISOU 1127 C GLU A 178 1372 2905 1760 -93 215 329 C

ATOM 1128 O GLU A 178 -12.829 2 723 -18.227 1.00 18.74 O

ANISOU 1128 O GLU A 178 2208 3245 1665 -352 138 289 O

ATOM 1129 CB GLU A 178 -14.664 0 195 -18.908 1.00 19.86 C

ANISOU 1129 CB GLU A 178 2129 3015 2399 -517 224 396 C

ATOM 1130 CG GLU A 178 -14.916 -1 306 -18.923 1.00 21.99 C

ANISOU 1130 CG GLU A 178 3014 3138 2203 -663 410 157 C

ATOM 1131 CD GLU A 178 -16.304 -1 678 -18.416 1.00 28.85 C

ANISOU 1131 CD GLU A 178 3283 4217 3458 -922 755 224 C

ATOM 1132 OE1 GLU A 178 -17.137 -0 772 -18.193 1.00 27.36 O

ANISOU 1132 OE1 GLU A 178 2531 3972 3890 -607 -38 1395 O

ATOM 1133 OE2 GLU A 178 -16.561 -2 891 -18.233 1.00 33.71 O

ANISOU 1133 OE2 GLU A 178 4713 4772 3321 -1711 289 618 O

ATOM 1134 N PHE A 179 -13.350 2 699 -20.444 1.00 14.69 N

ANISOU 1134 N PHE A 179 1127 2772 1682 64 -4 153 N

ATOM 1135 CA PHE A 179 -13.373 4 141 -20.646 1.00 14.60 C

ANISOU 1135 CA PHE A 179 1326 2697 1523 -106 76 287 C

ATOM 1136 C PHE A 179 -14.798 4 543 -20.903 1.00 14.73 C

ANISOU 1136 C PHE A 179 1467 2425 1702 1 -34 281 C

ATOM 1137 O PHE A 179 -15.468 3 978 -21.778 1.00 15.95 O

ANISOU 1137 O PHE A 179 1764 2899 1395 198 -13 124 O

ATOM 1138 CB PHE A 179 -12.449 4 578 -21.807 1.00 14.17 C

ANISOU 1138 CB PHE A 179 971 3004 1409 49 -20 255 C

ATOM 1139 CG PHE A 179 -11.093 3 930 -21.759 1.00 13.31 C

ANISOU 1139 CG PHE A 179 1032 2443 1580 -42 -411 416 C

ATOM 1140 CD1 PHE A 179 -10.372 3 917 -20.578 1.00 15.02 C

ANISOU 1140 CD1 PHE A 179 1221 2805 1679 -122 -534 122 C

ATOM 1141 CD2 PHE A 179 -10.538 3 334 -22.893 1.00 16.49 C

ANISOU 1141 CD2 PHE A 179 1273 2583 2408 45 -405 -166 C

ATOM 1142 CE1 PHE A 179 -9.141 3 293 -20.511 1.00 18.37 C

ANISOU 1142 CE1 PHE A 179 1665 3127 2187 486 -435 -255 C

ATOM 1143 CE2 PHE A 179 -9.290 2 724 -22.837 1.00 16.83 C

ANISOU 1143 CE2 PHE A 179 1135 2995 2262 5 12 10 C

ATOM 1144 CZ PHE A 179 -8.591 2 710 -21.641 1.00 18.07 C ANISOU 1144 CZ PHE A 179 1725 2884 2257 290 -177 -152 C

ATOM 1145 N LYS A 180 -15.259 5 503 -20.109 1 00 15.10 N

ANISOU 1145 N LYS A 180 1573 2073 2090 -89 -87 234 N

ATOM 1146 CA LYS A 180 -16.666 5 879 -20.081 1 00 15.93 C

ANISOU 1146 CA LYS A 180 1682 2383 1988 208 153 319 C

ATOM 1147 C LYS A 180 -16.888 7 388 -20.258 1 00 15.30 C

ANISOU 1147 C LYS A 180 1557 2264 1992 61 63 38 C

ATOM 1148 O LYS A 180 -15.962 8 199 -20.201 1 00 14.55 O

ANISOU 1148 O LYS A 180 1228 2316 1982 191 123 184 O

ATOM 1149 CB LYS A 180 -17.325 5 395 -18.789 1 00 17.29 C

ANISOU 1149 CB LYS A 180 1628 2779 2162 -350 134 319 C

ATOM 1150 CG LYS A 180 -17.194 3 911 -18.490 1 00 17.22 C

ANISOU 1150 CG LYS A 180 1456 3069 2017 -102 181 485 C

ATOM 1151 CD LYS A 180 -18.134 3 549 -17.350 1 00 22.49 C

ANISOU 1151 CD LYS A 180 2616 3432 2497 -420 641 1116 C

ATOM 1152 CE LYS A 180 -17.443 2 655 -16.336 1 00 30.03 C

ANISOU 1152 CE LYS A 180 3278 4596 3534 7 490 1708 C

ATOM 1153 NZ LYS A 180 -18.349 2 434 -15.180 1 00 41.09 N

ANISOU 1153 NZ LYS A 180 4793 6358 4458 -899 1471 1768 N

ATOM 1154 N ALA A 181 -18.139 7 750 -20.497 1 00 14.70 N

ANISOU 1154 N ALA A 181 1611 2322 1650 190 102 189 N

ATOM 1155 CA ALA A 181 -18.540 9 143 -20.622 1 00 14.59 C

ANISOU 1155 CA ALA A 181 1600 2178 1766 -4 -6 124 C

ATOM 1156 C ALA A 181 -18.433 9 870 -19.283 1 00 15.86 C

ANISOU 1156 C ALA A 181 1677 2466 1882 36 -202 -47 C

ATOM 1157 O ALA A 181 -18.103 11 068 -19.235 1 00 17.09 O

ANISOU 1157 O ALA A 181 1674 2560 2259 -22 -304 -138 O

ATOM 1158 CB ALA A 181 -19.962 9 214 -21.129 1 00 15.09 C

ANISOU 1158 CB ALA A 181 1885 2267 1579 212 -384 439 C

ATOM 1159 N GLU A 182 -18.715 9 145 -18.203 1 00 16.51 N

ANISOU 1159 N GLU A 182 1763 2628 1882 622 -204 169 N

ATOM 1160 CA GLU A 182 -18.740 9 723 -16.857 1 00 18.23 C

ANISOU 1160 CA GLU A 182 2057 2853 2017 885 17 -38 C

ATOM 1161 C GLU A 182 -18.035 8 825 -15.834 1 00 20.51 C

ANISOU 1161 C GLU A 182 2040 3916 1836 1395 -112 -154 C

ATOM 1162 O GLU A 182 -17.516 7 762 -16.178 1 00 21.82 O

ANISOU 1162 O GLU A 182 2861 3318 2109 1177 265 382 O

ATOM 1163 CB GLU A 182 -20.192 9 981 -16.416 1 00 18.75 C

ANISOU 1163 CB GLU A 182 1972 2867 2286 1000 10 215 C

ATOM 1164 CG GLU A 182 -20.940 10 978 -17.314 1 00 22.11 C

ANISOU 1164 CG GLU A 182 2571 2947 2881 942 -406 431 C

ATOM 1165 CD GLU A 182 -22.360 11 267 -16.855 1 00 26.97 C

ANISOU 1165 CD GLU A 182 3428 3236 3581 1271 537 -489 C

ATOM 1166 OE1 GLU A 182 -23.249 10 419 -17.100 1 00 27.58 O

ANISOU 1166 OE1 GLU A 182 2818 4575 3084 1084 86 -80 O

ATOM 1167 OE2 GLU A 182 -22.593 12 344 -16.248 1 00 29.00 O

ANISOU 1167 OE2 GLU A 182 3483 4157 3378 1137 1162 -1199 O

ATOM 1168 N GLY A 183 -18.030 9 256 -14.575 1 00 24.62 N

ANISOU 1168 N GLY A 183 3010 4740 1604 1593 121 -12 N

ATOM 1169 CA GLY A 183 -17.430 8 471 -13.492 1 00 25.84 C

ANISOU 1169 CA GLY A 183 3511 4381 1925 1082 -138 202 C

ATOM 1170 C GLY A 183 -15.990 8 852 -13.262 1 00 26.89 C

ANISOU 1170 C GLY A 183 3798 4483 1934 713 -245 391 C

ATOM 1171 O GLY A 183 -15.590 9 987 -13.544 1 00 30.11 O

ANISOU 1171 O GLY A 183 4864 4195 2380 438 -632 -271 O

ATOM 1172 N ASN A 184 -15.209 7 899 -12.749 1 00 28.68 N

ANISOU 1172 N ASN A 184 3184 5420 2291 566 -292 1000 N

ATOM 1173 CA ASN A 184 -13.810 8 121 -12.455 1 00 28.55 C

ANISOU 1173 CA ASN A 184 3344 5226 2274 937 -779 285 C

ATOM 1174 C ASN A 184 -13.125 8 885 -13.575 1 00 26.22 C

ANISOU 1174 C ASN A 184 3339 3979 2643 593 -580 -342 C ATOM 1175 O ASN A 184 -13.043 8 398 -14.708 1 00 26.60 O

ANISOU 1175 O ASN A 184 2888 4412 2806 375 -679 -810 O

ATOM 1176 CB ASN A 184 -13.108 6 786 -12.224 1 00 29.94 C

ANISOU 1176 CB ASN A 184 2970 5347 3059 855 -959 765 C

ATOM 1177 CG ASN A 184 -11.748 6 948 -11.576 1 00 30.78 C

ANISOU 1177 CG ASN A 184 3259 5549 2884 540 -1220 1196 C

ATOM 1178 OD1 ASN A 184 -11.053 7 944 -11.779 1 00 29.32 O

ANISOU 1178 OD1 ASN A 184 2325 5905 2908 577 -385 582 O

ATOM 1179 ND2 ASN A 184 -11.367 5 968 -10.789 1 00 36.67 N

ANISOU 1179 ND2 ASN A 184 4015 6138 3777 1715 -89 1864 N

ATOM 1180 N SER A 185 -12.639 10 081 -13.251 1 00 25.24 N

ANISOU 1180 N SER A 185 2495 3782 3310 1077 -505 -689 N

ATOM 1181 CA SER A 185 -12.084 10 981 -14.260 1 00 28.18 C

ANISOU 1181 CA SER A 185 3342 3968 3397 628 -200 -745 C

ATOM 1182 C SER A 185 -10.769 10 443 -14.839 1 00 24.85 C

ANISOU 1182 C SER A 185 2845 3547 3050 342 -522 -469 C

ATOM 1183 O SER A 185 -10.305 10 914 -15.870 1 00 25.52 O

ANISOU 1183 O SER A 185 3511 3245 2940 464 -826 -81 O

ATOM 1184 CB SER A 185 -11.926 12 403 -13.710 1 00 27.91 C

ANISOU 1184 CB SER A 185 2378 4268 3957 -802 -244 -737 C

ATOM 1185 OG SER A 185 -10.943 12 456 -12.695 1 00 33.45 O

ANISOU 1185 OG SER A 185 3813 5283 3610 -62 -487 -1847 O

ATOM 1186 N LYS A 186 -10.182 9 443 -14.184 1 00 23.34 N

ANISOU 1186 N LYS A 186 2796 3536 2534 92 -934 -716 N

ATOM 1187 CA LYS A 186 -8.981 8 785 -14.720 1 00 22.77 C

ANISOU 1187 CA LYS A 186 2798 3234 2617 289 -912 -302 C

ATOM 1188 C LYS A 186 -9.290 7 999 -15.990 1 00 22.25 C

ANISOU 1188 C LYS A 186 2568 3843 2044 -143 -153 -90 C

ATOM 1189 O LYS A 186 -8.402 7 781 -16.823 1 00 21.97 O

ANISOU 1189 O LYS A 186 2191 3777 2378 78 -145 122 O

ATOM 1190 CB LYS A 186 -8.381 7 836 -13.690 1 00 24.46 C

ANISOU 1190 CB LYS A 186 2946 4038 2308 547 -1009 -385 C

ATOM 1191 CG LYS A 186 -7.721 8 528 -12.507 1 00 26.46 C

ANISOU 1191 CG LYS A 186 2605 4418 3030 412 -2014 -151 C

ATOM 1192 CD LYS A 186 -7.307 7 492 -11.468 1 00 31.09 C

ANISOU 1192 CD LYS A 186 3282 5664 2866 741 -1956 297 C

ATOM 1193 CE LYS A 186 -6.555 8 118 -10.306 1 00 34.38 C

ANISOU 1193 CE LYS A 186 4334 6852 1874 816 -1243 -268 C

ATOM 1194 NZ LYS A 186 -6.156 7 061 -9.337 1 00 39.53 N

ANISOU 1194 NZ LYS A 186 4951 6975 3091 1140 -1958 -134 N

ATOM 1195 N PHE A 187 -10.552 7 588 -16.122 1 00 20.54 N

ANISOU 1195 N PHE A 187 2278 3169 2356 313 -756 197 N

ATOM 1196 CA PHE A 187 -10.967 6 612 -17.123 1 00 18.74 C

ANISOU 1196 CA PHE A 187 2205 2740 2174 329 -133 290 C

ATOM 1197 C PHE A 187 -12.022 7 155 -18.080 1 00 16.11 C

ANISOU 1197 C PHE A 187 1589 2486 2045 81 -14 -30 C

ATOM 1198 O PHE A 187 -12.571 6 405 -18.883 1 00 22.66 O

ANISOU 1198 O PHE A 187 2846 2729 3034 339 -952 -414 O

ATOM 1199 CB PHE A 187 -11.476 5 322 -16.437 1 00 21.83 C

ANISOU 1199 CB PHE A 187 2616 3203 2476 46 -214 715 C

ATOM 1200 CG PHE A 187 -10.390 4 514 -15.785 1 00 27.99 C

ANISOU 1200 CG PHE A 187 3712 3451 3470 770 -439 803 C

ATOM 1201 CD1 PHE A 187 -9.633 3 608 -16.528 1 00 28.48 C

ANISOU 1201 CD1 PHE A 187 2980 4795 3043 995 298 1398 C

ATOM 1202 CD2 PHE A 187 -10.109 4 667 -14.428 1 00 28.23 C

ANISOU 1202 CD2 PHE A 187 3593 3662 3469 637 -308 815 C

ATOM 1203 CE1 PHE A 187 -8.628 2 867 -15.926 1 00 37.61 C

ANISOU 1203 CE1 PHE A 187 3810 5531 4948 1399 -480 1749 C

ATOM 1204 CE2 PHE A 187 -9.103 3 929 -13.819 1 00 34.28 C

ANISOU 1204 CE2 PHE A 187 4571 4366 4085 1294 -852 676 C

ATOM 1205 CZ PHE A 187 -8.362 3 028 -14.568 1 00 34.52 C ANISOU 1205 CZ PHE A 187 2344 5850 4921 1617 - 134 1135 C

ATOM 1206 N THR A 188 -12.311 8. .452 -18. .006 1. .00 15. .77 N

ANISOU 1206 N THR A 188 1662 2433 1893 50 -8 132 N

ATOM 1207 CA THR A 188 -13.271 9. .038 -18. .953 1. .00 15. .96 C

ANISOU 1207 CA THR A 188 2098 2697 1267 264 89 -1 C

ATOM 1208 C THR A 188 -12.577 9. .315 -20. .279 1. .00 14. .80 C

ANISOU 1208 C THR A 188 1546 2479 1599 -211 91 149 C

ATOM 1209 O THR A 188 -11.425 9. .757 -20. .307 1. .00 14. .89 O

ANISOU 1209 O THR A 188 1260 2556 1840 50 31 0 O

ATOM 1210 CB THR A 188 -13.916 10. .340 -18. .447 1. .00 17. .74 C

ANISOU 1210 CB THR A 188 2233 2406 2098 -72 81 -241 C

ATOM 1211 OG1 THR A 188 -12.883 11. .265 -18. .066 1. .00 18. .48 O

ANISOU 1211 OG1 THR A 188 2215 2122 2682 -45 162 108 O

ATOM 1212 CG2 THR A 188 -14.820 10. .050 -17. .264 1. .00 17. .23 c

ANISOU 1212 CG2 THR A 188 1980 2756 1810 108 - 156 -267 c

ATOM 1213 N TYR A 189 -13.278 9. .028 -21. .372 1. .00 14. .68 N

ANISOU 1213 N TYR A 189 1600 2816 1159 -136 439 -132 N

ATOM 1214 CA TYR A 189 -12.800 9. .423 -22. .695 1. .00 11. .10 C

ANISOU 1214 CA TYR A 189 1256 1872 1090 -233 98 -109 C

ATOM 1215 C TYR A 189 -13.219 10. .874 -22. .939 1. .00 13. .97 C

ANISOU 1215 C TYR A 189 1535 2200 1572 258 208 -56 C

ATOM 1216 O TYR A 189 -13.944 11. .477 -22. .126 1. .00 13. .86 O

ANISOU 1216 O TYR A 189 1541 1960 1765 121 16 -484 O

ATOM 1217 CB TYR A 189 -13.334 8. .473 -23. .783 1. .00 11. .20 c

ANISOU 1217 CB TYR A 189 1183 1704 1369 99 357 -466 c

ATOM 1218 CG TYR A 189 -14.847 8. .219 -23. .795 1. .00 11. .22 c

ANISOU 1218 CG TYR A 189 1190 1508 1565 56 408 -16 c

ATOM 1219 CD1 TYR A 189 -15.766 9. .288 -23. .987 1. .00 14. .24 c

ANISOU 1219 CD1 TYR A 189 1450 1897 2064 343 184 -45 c

ATOM 1220 CD2 TYR A 189 -15.367 6. .915 -23. .678 1. .00 11. .13 c

ANISOU 1220 CD2 TYR A 189 1159 1362 1707 312 322 -34 c

ATOM 1221 CE1 TYR A 189 -17.140 9. .062 -24. .024 1. .00 11. .70 c

ANISOU 1221 CE1 TYR A 189 1698 1310 1435 -366 88 -32 c

ATOM 1222 CE2 TYR A 189 -16.752 6. .676 -23. .716 1. .00 11. .84 c

ANISOU 1222 CE2 TYR A 189 1269 1764 1463 -37 251 72 c

ATOM 1223 CZ TYR A 189 -17.617 7. .752 -23. .911 1. .00 13. .38 c

ANISOU 1223 CZ TYR A 189 1758 1210 2114 -204 234 10 c

ATOM 1224 OH TYR A 189 -18.973 7. .557 -23. .964 1. .00 13. .57 0

ANISOU 1224 OH TYR A 189 1716 1640 1799 -146 - 198 -191 0

ATOM 1225 N THR A 190 -12.741 11. .445 -24. .038 1. .00 12. .83 N

ANISOU 1225 N THR A 190 936 2052 1885 -230 212 -114 N

ATOM 1226 CA THR A 190 -13.225 12. .749 -24. .463 1. .00 15. .85 c

ANISOU 1226 CA THR A 190 1580 2449 1990 -31 - 422 -38 c

ATOM 1227 C THR A 190 -13.805 12. .614 -25. .859 1. .00 14. .82 c

ANISOU 1227 C THR A 190 1485 2205 1939 188 - 368 -341 c

ATOM 1228 O THR A 190 -13.364 11. .766 -26. .653 1. .00 16. .22 0

ANISOU 1228 O THR A 190 1763 2800 1600 827 - 376 -164 0

ATOM 1229 CB THR A 190 -12.152 13. .851 -24. .423 1. .00 20. .83 c

ANISOU 1229 CB THR A 190 1693 3271 2950 -495 - 530 -289 c

ATOM 1230 OG1 THR A 190 -11.251 13. .675 -25. .510 1. .00 24. .16 0

ANISOU 1230 OG1 THR A 190 1807 3945 3427 -882 - 201 -155 0

ATOM 1231 CG2 THR A 190 -11.388 13. .815 -23. .102 1. .00 24. .22 c

ANISOU 1231 CG2 THR A 190 2719 3398 3086 -910 - 942 77 c

ATOM 1232 N VAL A 191 -14.794 13. .450 -26. .151 1. .00 11. .05 N

ANISOU 1232 N VAL A 191 834 1739 1624 -225 55 -244 N

ATOM 1233 CA VAL A 191 -15.502 13. .390 -27. .419 1. .00 11. .54 C

ANISOU 1233 CA VAL A 191 883 1888 1613 -451 44 31 C

ATOM 1234 C VAL A 191 -15.050 14. .567 -28. .284 1. .00 12. .36 c

ANISOU 1234 C VAL A 191 1348 1752 1596 -118 246 43 c

ATOM 1235 O VAL A 191 -15.102 15. .725 -27. .845 1. .00 12. .57 0

ANISOU 1235 O VAL A 191 885 1767 2121 -453 113 -130 0 ATOM 1236 CB VAL A 191 -17.027 13..400 -27..151 1..00 10..99 C

ANISOU 1236 CB VAL A 191 863 1939 1371 -186 -71 191 C

ATOM 1237 CGI VAL A 191 -17.832 13. .570 -28. .440 1. .00 11. .32 C

ANISOU 1237 CGI VAL A 191 1359 1897 1042 -276 -56 -54 C

ATOM 1238 CG2 VAL A 191 -17.403 12. .109 -26. .422 1. .00 11. .60 C

ANISOU 1238 CG2 VAL A 191 711 1873 1824 -505 165 21 C

ATOM 1239 N LEU A 192 -14.581 14. .258 -29. .497 1. .00 13. .22 N

ANISOU 1239 N LEU A 192 1708 1841 1473 -164 349 298 N

ATOM 1240 CA LEU A 192 -14.004 15. .258 -30. .395 1. .00 12. .51 C

ANISOU 1240 CA LEU A 192 1197 1918 1639 -182 563 180 C

ATOM 1241 C LEU A 192 -15.024 15. .836 -31. .381 1. .00 12. .68 C

ANISOU 1241 C LEU A 192 1485 1366 1964 92 533 267 C

ATOM 1242 O LEU A 192 -14.853 16. .949 -31. .853 1. .00 14. .21 O

ANISOU 1242 O LEU A 192 1671 1663 2064 -160 227 599 O

ATOM 1243 CB LEU A 192 -12.829 14. .649 -31. .157 1. .00 12. .21 C

ANISOU 1243 CB LEU A 192 1172 1517 1950 133 206 -68 C

ATOM 1244 CG LEU A 192 -11.697 14. .091 -30. .257 1. .00 14. .42 c

ANISOU 1244 CG LEU A 192 971 2338 2168 221 126 ^■265 c

ATOM 1245 CD1 LEU A 192 -10.518 13. .684 -31. .121 1. .00 13. .30 c

ANISOU 1245 CD1 LEU A 192 602 2338 2114 -48 42 ^■157 c

ATOM 1246 CD2 LEU A 192 -11.288 15. .102 -29. .188 1. .00 14. .91 c

ANISOU 1246 CD2 LEU A 192 1062 2440 2162 -161 -186 -31 c

ATOM 1247 N GLU A 193 -16.051 15. .048 -31. .711 1. .00 12. .42 N

ANISOU 1247 N GLU A 193 1518 1686 1515 68 459 74 N

ATOM 1248 CA GLU A 193 -17.190 15. .486 -32. .530 1. .00 13. .39 C

ANISOU 1248 CA GLU A 193 1344 1975 1765 -108 476 202 C

ATOM 1249 C GLU A 193 -18.321 14. .497 -32. .276 1. .00 14. .87 C

ANISOU 1249 C GLU A 193 1373 1869 2405 -200 175 71 C

ATOM 1250 O GLU A 193 -18.070 13. .328 -31. .971 1. .00 13. .27 O

ANISOU 1250 O GLU A 193 1440 2093 1506 -117 -103 99 0

ATOM 1251 CB GLU A 193 -16.831 15. .547 -34. .028 1. .00 14. .84 c

ANISOU 1251 CB GLU A 193 1843 2006 1787 71 598 ^■154 c

ATOM 1252 CG GLU A 193 -16.706 14. .204 -34. .728 1. .00 17. .12 c

ANISOU 1252 CG GLU A 193 2278 2380 1845 -205 415 ^■569 c

ATOM 1253 CD GLU A 193 -16.286 14. .364 -36. .186 1. .00 21. .81 c

ANISOU 1253 CD GLU A 193 2555 3404 2325 -527 1121 ^■205 c

ATOM 1254 OE1 GLU A 193 -15.104 14. .671 -36. .432 1. .00 23. .81 0

ANISOU 1254 OE1 GLU A 193 2192 4431 2423 -505 443 123 0

ATOM 1255 OE2 GLU A 193 -17.130 14. .199 -37. .088 1. .00 24. .45 0

ANISOU 1255 OE2 GLU A 193 3030 4042 2218 -324 876 230 0

ATOM 1256 N ASP A 194 -19.565 14. .960 -32. .359 1. .00 14. .16 N

ANISOU 1256 N ASP A 194 1214 2099 2064 -346 225 204 N

ATOM 1257 CA ASP A 194 -20.683 14. .078 -32. .036 1. .00 13. .07 C

ANISOU 1257 CA ASP A 194 1107 2006 1851 -410 -55 -67 C

ATOM 1258 C ASP A 194 -21.840 14. .329 -32. .988 1. .00 12. .85 c

ANISOU 1258 C ASP A 194 1477 1687 1716 -211 -153 -62 c

ATOM 1259 O ASP A 194 -22.666 15. .206 -32. .739 1. .00 15. .54 0

ANISOU 1259 O ASP A 194 1632 2267 2004 323 -357 90 0

ATOM 1260 CB ASP A 194 -21.109 14. .288 -30. .570 1. .00 14. .66 c

ANISOU 1260 CB ASP A 194 1362 2301 1907 -462 209 177 c

ATOM 1261 CG ASP A 194 -22.179 13. .275 -30. .085 1. .00 13. .07 c

ANISOU 1261 CG ASP A 194 1095 1992 1878 -247 44 130 c

ATOM 1262 OD1 ASP A 194 -22.587 12. .351 -30. .836 1. .00 13. .04 0

ANISOU 1262 OD1 ASP A 194 1355 1819 1778 -31 120 113 0

ATOM 1263 OD2 ASP A 194 -22.600 13. .410 -28. .917 1. .00 12. .36 0

ANISOU 1263 OD2 ASP A 194 786 1918 1991 159 108 -59 0

ATOM 1264 N GLY A 195 -21.907 13. .536 -34. .059 1. .00 12. .43 N

ANISOU 1264 N GLY A 195 1218 1821 1683 -187 -76 ^■153 N

ATOM 1265 CA GLY A 195 -23.023 13. .662 -35. .001 1. .00 14. .81 C

ANISOU 1265 CA GLY A 195 1846 2038 1740 -115 -435 -28 C

ATOM 1266 C GLY A 195 -24.128 12. .636 -34. .814 1. .00 14. .29 c ANISOU 1266 C GLY A 195 1672 2197 1557 30 48 -60 C

ATOM 1267 O GLY A 195 -25.023 12. ,546 -35. .659 1. .00 17. .90 O

ANISOU 1267 O GLY A 195 1886 2826 2087 20 -220 -250 O

ATOM 1268 N CYS A 196 -24.086 11. ,881 -33. .706 1. .00 13. .89 N

ANISOU 1268 N CYS A 196 1522 2013 1742 424 -257 -88 N

ATOM 1269 CA CYS A 196 -25.002 10. ,751 -33. .477 1. .00 12. .96 C

ANISOU 1269 CA CYS A 196 1441 1978 1505 395 -344 -164 C

ATOM 1270 C CYS A 196 -26.192 11. ,048 -32. .544 1. .00 13. .92 C

ANISOU 1270 C CYS A 196 1837 2076 1375 549 -251 -374 C

ATOM 1271 O CYS A 196 -26.883 10. ,118 -32. .088 1. .00 16. .93 O

ANISOU 1271 O CYS A 196 1634 2522 2276 224 -375 -374 O

ATOM 1272 CB CYS A 196 -24.225 9. ,527 -32. .974 1. .00 13. .25 C

ANISOU 1272 CB CYS A 196 1582 1707 1743 311 -348 -285 C

ATOM 1273 SG CYS A 196 -22.993 8. ,946 -34. .175 1. .00 15. .62 s

ANISOU 1273 SG CYS A 196 1789 2230 1915 164 -204 -507 s

ATOM 1274 N THR A 197 -26.446 12. ,329 -32. .288 1. .00 13. .96 N

ANISOU 1274 N THR A 197 1676 1954 1674 407 -644 -237 N

ATOM 1275 CA THR A 197 -27.343 12. ,736 -31. .192 1. .00 15. .95 C

ANISOU 1275 CA THR A 197 1879 2160 2019 122 -176 -292 C

ATOM 1276 C THR A 197 -28.851 12. ,536 -31. .438 1. .00 16. .93 C

ANISOU 1276 C THR A 197 1880 2343 2207 189 -149 -269 C

ATOM 1277 O THR A 197 -29.638 12. ,611 -30. .486 1. .00 18. .53 O

ANISOU 1277 O THR A 197 1201 3199 2637 112 -145 -582 O

ATOM 1278 CB THR A 197 -27.099 14. ,201 -30. .731 1. .00 15. .44 C

ANISOU 1278 CB THR A 197 1694 2191 1981 -48 -340 -226 c

ATOM 1279 OG1 THR A 197 -27.499 15. ,105 -31. .768 1. .00 16. .36 0

ANISOU 1279 OG1 THR A 197 1984 1928 2302 72 -97 -70 0

ATOM 1280 CG2 THR A 197 -25.626 14. ,446 -30. .386 1. .00 14. .29 c

ANISOU 1280 CG2 THR A 197 1274 2246 1908 264 250 -244 c

ATOM 1281 N LYS A 198 -29.238 12. ,265 -32. .685 1. .00 16. .71 N

ANISOU 1281 N LYS A 198 1658 2264 2423 75 -457 -267 N

ATOM 1282 CA LYS A 198 -30.636 12. ,014 -33. .058 1. .00 17. .27 C

ANISOU 1282 CA LYS A 198 1736 2729 2093 363 -698 -408 C

ATOM 1283 C LYS A 198 -30.753 10. ,815 -33. .986 1. .00 19. .23 C

ANISOU 1283 C LYS A 198 2156 2968 2179 -146 -748 -458 C

ATOM 1284 O LYS A 198 -29.804 10. ,475 -34. .706 1. .00 21. .24 O

ANISOU 1284 O LYS A 198 1765 3462 2842 -47 -605 -395 0

ATOM 1285 CB LYS A 198 -31.218 13. ,224 -33. .792 1. .00 23. .26 c

ANISOU 1285 CB LYS A 198 2991 2870 2977 674 -1321 -329 c

ATOM 1286 CG LYS A 198 -31.326 14. ,506 -32. .981 1. .00 25. .42 c

ANISOU 1286 CG LYS A 198 3216 2925 3517 756 -960 -514 c

ATOM 1287 CD LYS A 198 -31.819 15. ,663 -33. .839 1. .00 35. .51 c

ANISOU 1287 CD LYS A 198 5843 4593 3053 992 -295 795 c

ATOM 1288 CE LYS A 198 -30.665 16. ,343 -34. .574 1. .00 29. .67 c

ANISOU 1288 CE LYS A 198 6677 2586 2008 2827 321 1508 c

ATOM 1289 NZ LYS A 198 -31.086 17. ,417 -35. .490 1. .00 47. .44 N

ANISOU 1289 NZ LYS A 198 8841 4614 4568 1714 -1858 3300 N

ATOM 1290 N HIS A 199 -31.925 10. ,194 -33. .995 1. .00 19. .30 N

ANISOU 1290 N HIS A 199 2106 2839 2387 -167 -661 -297 N

ATOM 1291 CA HIS A 199 -32.255 9. ,210 -35. .017 1. .00 20. .25 C

ANISOU 1291 CA HIS A 199 2471 2796 2426 -122 -755 -258 C

ATOM 1292 C HIS A 199 -32.829 9. ,958 -36. .188 1. .00 23. .13 C

ANISOU 1292 C HIS A 199 3019 3087 2679 108 -800 -39 C

ATOM 1293 O HIS A 199 -33.943 10. ,491 -36. .119 1. .00 25. .78 O

ANISOU 1293 O HIS A 199 3302 3663 2829 420 -1154 -693 O

ATOM 1294 CB HIS A 199 -33.308 8. ,231 -34. .504 1. .00 21. .90 C

ANISOU 1294 CB HIS A 199 2569 2791 2959 17 -375 315 C

ATOM 1295 CG HIS A 199 -32.852 7. ,339 -33. .366 1. .00 20. .36 C

ANISOU 1295 CG HIS A 199 1489 3297 2946 320 -679 114 C

ATOM 1296 ND1 HIS A 199 -33.565 6. ,260 -32. .978 1. .00 21. .92 N

ANISOU 1296 ND1 HIS A 199 2161 2918 3247 142 -956 -341 N ATOM 1297 CD2 HIS A 199 -31.716 7..371 -32..546 1..00 19..76 C

ANISOU 1297 CD2 HIS A 199 2376 2541 2590 613 -1150 -121 C

ATOM 1298 CE1 HIS A 199 -32.941 5. .643 -31. .960 1. .00 22. .40 C

ANISOU 1298 CE1 HIS A 199 2712 3169 2628 -1 -508 -38 C

ATOM 1299 NE2 HIS A 199 -31.815 6. .330 -31. .683 1. .00 20. .16 N

ANISOU 1299 NE2 HIS A 199 2088 2791 2780 506 -613 -102 N

ATOM 1300 N THR A 200 -32.083 10. .017 -37. .279 1. .00 24. .22 N

ANISOU 1300 N THR A 200 2918 3660 2624 -119 -955 -139 N

ATOM 1301 CA THR A 200 -32.520 10. .765 -38. .447 1. .00 22. .81 C

ANISOU 1301 CA THR A 200 2347 3410 2906 118 -1256 -289 C

ATOM 1302 C THR A 200 -32.733 9. .857 -39. .645 1. .00 21. .04 C

ANISOU 1302 C THR A 200 1843 3737 2414 256 -1755 63 C

ATOM 1303 O THR A 200 -33.197 10. .319 -40. .682 1. .00 27. .56 O

ANISOU 1303 O THR A 200 2662 4529 3279 684 -2238 850 O

ATOM 1304 CB THR A 200 -31.462 11. .796 -38. .866 1. .00 23. .44 C

ANISOU 1304 CB THR A 200 2630 3093 3182 173 -1232 -34 C

ATOM 1305 OG1 THR A 200 -30.275 11. .095 -39. .277 1. .00 24. .73 O

ANISOU 1305 OG1 THR A 200 2785 4179 2431 100 -824 -660 O

ATOM 1306 CG2 THR A 200 -31.147 12. .747 -37. .709 1. .00 24. .75 C

ANISOU 1306 CG2 THR A 200 2983 2863 3558 847 -819 -445 C

ATOM 1307 N GLY A 201 -32.373 8. .578 -39. .517 1. .00 21. .19 N

ANISOU 1307 N GLY A 201 1829 3218 3002 -Ill -1147 -483 N

ATOM 1308 CA GLY A 201 -32.433 7. .638 -40. .644 1. .00 23. .22 C

ANISOU 1308 CA GLY A 201 2315 3714 2793 -168 -1408 -578 C

ATOM 1309 C GLY A 201 -31.233 7. .788 -41. .565 1. .00 26. .13 C

ANISOU 1309 C GLY A 201 2512 4412 3003 118 -1357 - 1101 C

ATOM 1310 O GLY A 201 -31.141 7. .117 -42. .591 1. .00 27. .11 O

ANISOU 1310 O GLY A 201 2200 4783 3316 107 -1337 - 1465 O

ATOM 1311 N GLU A 202 -30.312 8. .677 -41. .198 1. .00 25. .10 N

ANISOU 1311 N GLU A 202 2302 3737 3497 209 -1069 -432 N

ATOM 1312 CA GLU A 202 -29.101 8. .906 -41. .975 1. .00 24. .29 C

ANISOU 1312 CA GLU A 202 2219 4128 2881 353 -1417 351 C

ATOM 1313 C GLU A 202 -27.896 8. .462 -41. .179 1. .00 21. .81 C

ANISOU 1313 C GLU A 202 1498 3757 3031 87 -1205 -82 C

ATOM 1314 O GLU A 202 -27.987 8. .260 -39. .955 1. .00 25. .60 O

ANISOU 1314 O GLU A 202 2286 4373 3068 472 -570 -467 O

ATOM 1315 CB GLU A 202 -28.958 10. .385 -42. .314 1. .00 30. .07 C

ANISOU 1315 CB GLU A 202 3450 4172 3800 283 -1232 162 C

ATOM 1316 CG GLU A 202 -30.263 11. .014 -42. .778 1. .00 36. .80 c

ANISOU 1316 CG GLU A 202 3558 5780 4641 599 -1286 859 c

ATOM 1317 CD GLU A 202 -30.061 12. .084 -43. .817 1. .00 45. .98 c

ANISOU 1317 CD GLU A 202 4726 6889 5852 -836 -189 1279 c

ATOM 1318 OE1 GLU A 202 -29.484 13. .144 -43. .482 1. .00 56. .64 0

ANISOU 1318 OE1 GLU A 202 6781 6792 7946 -1136 -287 226 0

ATOM 1319 OE2 GLU A 202 -30.497 11. .860 -44. .968 1. .00 63. .57 0

ANISOU 1319 OE2 GLU A 202 7769 10279 6105 -905 -116 -708 0

ATOM 1320 N TRP A 203 -26.773 8. .304 -41. .880 1. .00 21. .03 N

ANISOU 1320 N TRP A 203 2414 3004 2570 518 -841 -85 N

ATOM 1321 CA TRP A 203 -25.483 7. .966 -41. .272 1. .00 20. .30 C

ANISOU 1321 CA TRP A 203 2505 2885 2324 763 -856 -291 C

ATOM 1322 C TRP A 203 -24.697 9. .158 -40. .818 1. .00 19. .44 C

ANISOU 1322 C TRP A 203 2319 2928 2137 674 -969 174 C

ATOM 1323 O TRP A 203 -24.596 10. .176 -41. .525 1. .00 18. .16 0

ANISOU 1323 O TRP A 203 1873 3238 1788 353 -709 190 0

ATOM 1324 CB TRP A 203 -24.638 7. .183 -42. .268 1. .00 21. .51 c

ANISOU 1324 CB TRP A 203 2482 3078 2613 894 -580 -166 c

ATOM 1325 CG TRP A 203 -25.052 5. .748 -42. .345 1. .00 23. .06 c

ANISOU 1325 CG TRP A 203 2692 3182 2887 744 -575 20 c

ATOM 1326 CD1 TRP A 203 -25.889 5. .146 -43. .283 1. .00 23. .83 c

ANISOU 1326 CD1 TRP A 203 3422 3322 2307 501 -13 -523 c

ATOM 1327 CD2 TRP A 203 -24.682 4. .680 -41. .416 1. .00 20. .72 c ANISOU 1327 CD2 TRP A 203 2708 2993 2172 471 -1091 -327 C

ATOM 1328 NE1 TRP A 203 -26.041 3 807 -43.009 1 00 22.54 N

ANISOU 1328 NE1 TRP A 203 2995 3219 2349 302 -731 -400 N

ATOM 1329 CE2 TRP A 203 -25.349 3 467 -41.900 1 00 20.34 C

ANISOU 1329 CE2 TRP A 203 2022 2913 2792 425 -656 -267 C

ATOM 1330 CE3 TRP A 203 -23.869 4 603 -40.275 1 00 17.98 C

ANISOU 1330 CE3 TRP A 203 2426 2452 1950 795 -833 76 C

ATOM 1331 CZ2 TRP A 203 -25.212 2 247 -41.252 1 00 19.02 C

ANISOU 1331 CZ2 TRP A 203 2182 2712 2330 88 -358 -277 C

ATOM 1332 CZ3 TRP A 203 -23.759 3 375 -39.625 1 00 17.47 C

ANISOU 1332 CZ3 TRP A 203 2002 2368 2267 309 -734 48 C

ATOM 1333 CH2 TRP A 203 -24.401 2 220 -40.110 1 00 21.32 C

ANISOU 1333 CH2 TRP A 203 2119 3268 2712 -192 -535 -489 C

ATOM 1334 N SER A 204 -24.105 9 046 -39.635 1 00 16.99 N

ANISOU 1334 N SER A 204 2049 2650 1755 179 -711 -543 N

ATOM 1335 CA SER A 204 -23.192 10 076 -39.161 1 00 16.64 C

ANISOU 1335 CA SER A 204 1803 2436 2082 119 -494 -294 C

ATOM 1336 C SER A 204 -22.145 9 385 -38.300 1 00 14.68 C

ANISOU 1336 C SER A 204 1317 2180 2079 141 -135 -310 C

ATOM 1337 O SER A 204 -21.958 8 164 -38.403 1 00 13.70 O

ANISOU 1337 O SER A 204 1365 2212 1626 76 13 -143 O

ATOM 1338 CB SER A 204 -23.953 11 183 -38.415 1 00 17.15 C

ANISOU 1338 CB SER A 204 1998 2436 2079 134 -246 -161 C

ATOM 1339 OG SER A 204 -23.118 12 293 -38.116 1 00 17.29 O

ANISOU 1339 OG SER A 204 1942 2227 2398 561 -640 -93 O

ATOM 1340 N LYS A 205 -21.471 10 140 -37.442 1 00 13.92 N

ANISOU 1340 N LYS A 205 1086 2336 1864 218 -180 -151 N

ATOM 1341 CA LYS A 205 -20.361 9 564 -36.677 1 00 13.02 C

ANISOU 1341 CA LYS A 205 1335 2030 1580 379 -49 -161 C

ATOM 1342 C LYS A 205 -20.051 10 390 -35.456 1 00 12.79 C

ANISOU 1342 C LYS A 205 1286 2086 1485 162 -157 -17 C

ATOM 1343 O LYS A 205 -20.303 11 617 -35.427 1 00 14.52 O

ANISOU 1343 O LYS A 205 1705 2165 1645 364 -358 -18 O

ATOM 1344 CB LYS A 205 -19.103 9 415 -37.553 1 00 15.39 C

ANISOU 1344 CB LYS A 205 1565 2202 2077 195 336 -264 C

ATOM 1345 CG LYS A 205 -18.457 10 723 -37.984 1 00 17.09 C

ANISOU 1345 CG LYS A 205 2470 2460 1563 -15 292 -25 C

ATOM 1346 CD LYS A 205 -17.305 10 482 -38.964 1 00 19.89 C

ANISOU 1346 CD LYS A 205 2331 2651 2573 -28 521 -384 C

ATOM 1347 CE LYS A 205 -16.691 11 808 -39.403 1 00 28.42 C

ANISOU 1347 CE LYS A 205 3251 4013 3533 -632 889 981 C

ATOM 1348 NZ LYS A 205 -15.661 11 632 -40.465 1 00 35.18 N

ANISOU 1348 NZ LYS A 205 3232 4285 5847 -235 1684 381 N

ATOM 1349 N THR A 206 -19.511 9 707 -34.449 1 00 13.50 N

ANISOU 1349 N THR A 206 1566 2145 1415 35 -251 16 N

ATOM 1350 CA THR A 206 -19.016 10 336 -33.243 1 00 12.67 C

ANISOU 1350 CA THR A 206 1213 2366 1235 183 -185 29 C

ATOM 1351 C THR A 206 -17.583 9 839 -33.029 1 00 13.23 C

ANISOU 1351 C THR A 206 1333 2092 1601 264 -240 26 C

ATOM 1352 O THR A 206 -17.287 8 650 -33.230 1 00 12.76 O

ANISOU 1352 O THR A 206 1168 1873 1808 -329 -273 -243 O

ATOM 1353 CB THR A 206 -19.928 9 999 -32.042 1 00 11.93 C

ANISOU 1353 CB THR A 206 1099 2250 1183 114 -198 -263 C

ATOM 1354 OG1 THR A 206 -21.216 10 577 -32.278 1 00 13.27 O

ANISOU 1354 OG1 THR A 206 1114 2057 1871 38 -273 -197 O

ATOM 1355 CG2 THR A 206 -19.345 10 576 -30.718 1 00 13.36 C

ANISOU 1355 CG2 THR A 206 1620 2115 1339 175 -385 -333 C

ATOM 1356 N VAL A 207 -16.699 10 761 -32.659 1 00 13.69 N

ANISOU 1356 N VAL A 207 1366 1908 1924 221 -83 43 N

ATOM 1357 CA VAL A 207 -15.279 10 454 -32.507 1 00 12.92 C

ANISOU 1357 CA VAL A 207 1318 2052 1535 161 -147 26 C ATOM 1358 C VAL A 207 -14.865 10.,576 -31..050 1..00 12..61 C

ANISOU 1358 C VAL A 207 1314 1864 1611 92 -94 -297 C

ATOM 1359 O VAL A 207 -15.085 11. ,626 -30. .408 1. .00 11. .82 O

ANISOU 1359 O VAL A 207 1275 1596 1620 -45 - 225 -146 O

ATOM 1360 CB VAL A 207 -14.378 11. ,360 -33. .397 1. .00 15. .65 C

ANISOU 1360 CB VAL A 207 1984 2459 1501 104 -87 418 C

ATOM 1361 CGI VAL A 207 -12.901 11. ,036 -33. .172 1. .00 14. .31 C

ANISOU 1361 CGI VAL A 207 1828 1728 1880 29 345 7 C

ATOM 1362 CG2 VAL A 207 -14.745 11. ,211 -34. .889 1. .00 15. .14 C

ANISOU 1362 CG2 VAL A 207 2197 2006 1548 2 -62 84 C

ATOM 1363 N PHE A 208 -14.280 9. ,488 -30. .540 1. .00 12. .67 N

ANISOU 1363 N PHE A 208 1504 1899 1411 6 -41 -246 N

ATOM 1364 CA PHE A 208 -13.880 9. ,374 -29. .154 1. .00 13. .16 C

ANISOU 1364 CA PHE A 208 1138 2072 1789 -39 - 463 218 C

ATOM 1365 C PHE A 208 -12.366 9. ,357 -29. .083 1. .00 13. .65 C

ANISOU 1365 C PHE A 208 1101 2432 1651 52 -72 -120 C

ATOM 1366 O PHE A 208 -11.700 8. ,788 -29. .953 1. .00 12. .73 O

ANISOU 1366 O PHE A 208 905 2125 1805 219 - 186 -196 O

ATOM 1367 CB PHE A 208 -14.419 8. ,075 -28. .536 1. .00 12. .72 C

ANISOU 1367 CB PHE A 208 772 2101 1959 -98 - 218 83 C

ATOM 1368 CG PHE A 208 -15.913 7. ,992 -28. .519 1. .00 11. .67 c

ANISOU 1368 CG PHE A 208 796 2236 1401 -237 135 -7 c

ATOM 1369 CD1 PHE A 208 -16.612 7. ,561 -29. .660 1. .00 12. .53 c

ANISOU 1369 CD1 PHE A 208 1020 2268 1471 -138 -43 61 c

ATOM 1370 CD2 PHE A 208 -16.625 8. ,336 -27. .371 1. .00 11. .90 c

ANISOU 1370 CD2 PHE A 208 818 2009 1692 -52 213 -141 c

ATOM 1371 CE1 PHE A 208 -17.998 7. ,490 -29. .654 1. .00 12. .12 c

ANISOU 1371 CE1 PHE A 208 1036 2116 1450 -293 183 72 c

ATOM 1372 CE2 PHE A 208 -18.015 8. ,272 -27. .367 1. .00 12. .16 c

ANISOU 1372 CE2 PHE A 208 836 2147 1637 -348 - 130 38 c

ATOM 1373 CZ PHE A 208 -18.698 7. ,851 -28. .506 1. .00 13. .19 c

ANISOU 1373 CZ PHE A 208 1850 2139 1022 -297 80 27 c

ATOM 1374 N GLU A 209 -11.825 9. ,951 -28. .028 1. .00 12. .89 N

ANISOU 1374 N GLU A 209 1002 1847 2045 -84 - 133 -169 N

ATOM 1375 CA GLU A 209 -10.385 9. ,815 -27. .773 1. .00 13. .45 C

ANISOU 1375 CA GLU A 209 1029 2302 1780 14 - 192 -144 C

ATOM 1376 C GLU A 209 -10.105 9. ,419 -26. .330 1. .00 13. .40 c

ANISOU 1376 C GLU A 209 1150 2092 1850 93 -77 -23 c

ATOM 1377 O GLU A 209 -10.772 9. ,896 -25. .420 1. .00 14. .48 0

ANISOU 1377 O GLU A 209 1681 2310 1511 -134 - 213 -345 0

ATOM 1378 CB GLU A 209 -9.691 11. ,135 -28. .107 1. .00 17. .39 c

ANISOU 1378 CB GLU A 209 1497 2738 2370 -633 - 335 -253 c

ATOM 1379 CG GLU A 209 -8.235 11. ,202 -27. .704 1. .00 18. .52 c

ANISOU 1379 CG GLU A 209 1333 2918 2783 -587 -41 -250 c

ATOM 1380 CD GLU A 209 -7.676 12. ,566 -27. .992 1. .00 26. .08 c

ANISOU 1380 CD GLU A 209 2714 3646 3547 -1674 440 -393 c

ATOM 1381 OE1 GLU A 209 -7.792 13. ,461 -27. .124 1. .00 33. .25 0

ANISOU 1381 OE1 GLU A 209 3659 4502 4473 -1696 975 - 1144 0

ATOM 1382 OE2 GLU A 209 -7.173 12. ,750 -29. .109 1. .00 27. .39 0

ANISOU 1382 OE2 GLU A 209 3178 3739 3487 -1176 689 -393 0

ATOM 1383 N TYR A 210 -9.127 8. ,540 -26. .119 1. .00 14. .52 N

ANISOU 1383 N TYR A 210 1466 2265 1784 281 - 333 -23 N

ATOM 1384 CA TYR A 210 -8.592 8. ,334 -24. .772 1. .00 15. .82 C

ANISOU 1384 CA TYR A 210 1646 2842 1521 227 -77 -161 c

ATOM 1385 C TYR A 210 -7.109 8. ,651 -24. .788 1. .00 17. .05 c

ANISOU 1385 C TYR A 210 1684 2856 1938 347 - 229 -323 c

ATOM 1386 O TYR A 210 -6.373 8. ,138 -25. .630 1. .00 14. .50 0

ANISOU 1386 O TYR A 210 828 2626 2054 -113 - 246 -350 0

ATOM 1387 CB TYR A 210 -8.863 6. ,925 -24. .233 1. .00 17. .16 c

ANISOU 1387 CB TYR A 210 1991 2944 1585 423 - 350 88 c

ATOM 1388 CG TYR A 210 -8.471 6. ,776 -22. .773 1. .00 18. .19 c ANISOU 1388 CG TYR A 210 2095 3271 1543 436 -249 65 C

ATOM 1389 CD1 TYR A 210 -9.203 7. ,412 -21. .766 1. .00 19. .02 C

ANISOU 1389 CD1 TYR A 210 2191 3327 1707 241 -13 65 C

ATOM 1390 CD2 TYR A 210 -7.346 6. ,021 -22. .404 1. .00 17. .59 C

ANISOU 1390 CD2 TYR A 210 1885 3155 1641 288 -150 127 C

ATOM 1391 CE1 TYR A 210 -8.829 7. ,299 -20. .432 1. .00 19. .32 C

ANISOU 1391 CE1 TYR A 210 1981 3579 1778 679 95 527 C

ATOM 1392 CE2 TYR A 210 -6.969 5. ,885 -21. .079 1. .00 15. .71 C

ANISOU 1392 CE2 TYR A 210 1575 2851 1540 652 115 299 C

ATOM 1393 CZ TYR A 210 -7.710 6. ,532 -20. .094 1. .00 17. .09 C

ANISOU 1393 CZ TYR A 210 2284 2926 1282 758 390 615 C

ATOM 1394 OH TYR A 210 -7.346 6. ,419 -18. .783 1. .00 18. .04 O

ANISOU 1394 OH TYR A 210 2352 3006 1494 155 -255 178 O

ATOM 1395 N ARG A 211 -6.706 9. ,526 -23. .878 1. .00 17. .92 N

ANISOU 1395 N ARG A 211 1709 3108 1992 186 -619 -260 N

ATOM 1396 CA ARG A 211 -5.350 10. ,004 -23. .763 1. .00 18. .66 C

ANISOU 1396 CA ARG A 211 1566 2928 2595 498 -482 -604 C

ATOM 1397 C ARG A 211 -4.952 9. ,861 -22. .304 1. .00 20. .29 C

ANISOU 1397 C ARG A 211 1821 3161 2726 542 -730 -728 C

ATOM 1398 O ARG A 211 -5.726 10. ,185 -21. .433 1. .00 20. .49 O

ANISOU 1398 O ARG A 211 1342 3616 2826 415 -791 -733 O

ATOM 1399 CB ARG A 211 -5.305 11. ,455 -24. .177 1. .00 24. .93 C

ANISOU 1399 CB ARG A 211 2758 2774 3937 547 165 -696 C

ATOM 1400 CG ARG A 211 -3.940 12. ,078 -24. .220 1. .00 32. .69 c

ANISOU 1400 CG ARG A 211 3281 4455 4684 -113 -282 -307 c

ATOM 1401 CD ARG A 211 -4.014 13. ,500 -24. .751 1. .00 40. .43 c

ANISOU 1401 CD ARG A 211 5492 4661 5207 243 -320 158 c

ATOM 1402 NE ARG A 211 -4.499 13. ,535 -26. .118 1. .00 42. .78 N

ANISOU 1402 NE ARG A 211 5984 5145 5122 -269 -300 950 N

ATOM 1403 CZ ARG A 211 -3.714 13. ,599 -27. .181 1. .00 46. .04 C

ANISOU 1403 CZ ARG A 211 4665 6310 6517 -479 180 1326 C

ATOM 1404 NH1 ARG A 211 -2.413 13. ,658 -27. .034 1. .00 41. .24 N

ANISOU 1404 NH1 ARG A 211 4636 4422 6608 402 -735 2193 N

ATOM 1405 NH2 ARG A 211 -4.238 13. ,618 -28. .393 1. .00 47. .41 N

ANISOU 1405 NH2 ARG A 211 5139 6463 6408 -2235 -180 1348 N

ATOM 1406 N THR A 212 -3.745 9. ,357 -22. .047 1. .00 18. .15 N

ANISOU 1406 N THR A 212 1592 2945 2359 184 -726 -469 N

ATOM 1407 CA THR A 212 -3.339 9. ,051 -20. .680 1. .00 17. .74 C

ANISOU 1407 CA THR A 212 1555 2946 2238 180 -645 -602 C

ATOM 1408 C THR A 212 -1.816 9. ,064 -20. .520 1. .00 18. .58 C

ANISOU 1408 C THR A 212 1602 3095 2363 6 -649 -902 C

ATOM 1409 O THR A 212 -1.082 8. ,770 -21. .464 1. .00 17. .51 O

ANISOU 1409 O THR A 212 1540 3120 1993 126 -811 -566 O

ATOM 1410 CB THR A 212 -3.889 7. ,666 -20. .241 1. .00 18. .33 C

ANISOU 1410 CB THR A 212 1919 2713 2331 211 -558 -753 C

ATOM 1411 OG1 THR A 212 -3.541 7. ,408 -18. .880 1. .00 21. .75 O

ANISOU 1411 OG1 THR A 212 2694 3257 2311 0 -717 -753 O

ATOM 1412 CG2 THR A 212 -3.360 6. ,521 -21. .138 1. .00 15. .93 C

ANISOU 1412 CG2 THR A 212 1051 2343 2656 340 -418 -392 C

ATOM 1413 N ARG A 213 -1.352 9. ,401 -19. .323 1. .00 17. .40 N

ANISOU 1413 N ARG A 213 1773 2875 1962 133 -631 -376 N

ATOM 1414 CA ARG A 213 0.052 9. .153 -18. .957 1. .00 19. .34 C

ANISOU 1414 CA ARG A 213 1672 3060 2616 238 -320 -553 C

ATOM 1415 C ARG A 213 0.240 7. .725 -18. .430 1. .00 18. .56 C

ANISOU 1415 C ARG A 213 1586 3367 2100 176 -5 -151 C

ATOM 1416 O ARG A 213 1.359 7. .333 -18. .093 1. .00 21. .38 O

ANISOU 1416 O ARG A 213 1606 3857 2658 155 -222 555 O

ATOM 1417 CB ARG A 213 0.557 10. .170 -17. .918 1. .00 19. .80 C

ANISOU 1417 CB ARG A 213 2331 2798 2392 -145 8 -377 C

ATOM 1418 CG ARG A 213 0.409 11. .626 -18. .336 1. .00 24. .44 C

ANISOU 1418 CG ARG A 213 3118 2796 3369 -346 -177 -287 c ATOM 1419 CD ARG A 213 1.478 12..030 -19..328 1..00 33..03 C

ANISOU 1419 CD ARG A 213 4455 4532 3561 -667 341 -286 C

ATOM 1420 N LYS A 214 -0.841 6. ,949 -18. .342 1. .00 17. .92 N

ANISOU 1420 N LYS A 214 1906 2895 2007 -93 - 385 -512 N

ATOM 1421 CA LYS A 214 -0.725 5. ,537 -17. .940 1. .00 17. .83 C

ANISOU 1421 CA LYS A 214 2119 2826 1826 -144 - 336 -477 C

ATOM 1422 C LYS A 214 -0.979 4. ,648 -19. .156 1. .00 17. .37 C

ANISOU 1422 C LYS A 214 2033 2639 1926 -144 89 -565 C

ATOM 1423 O LYS A 214 -2.084 4. ,084 -19. .317 1. .00 15. .70 O

ANISOU 1423 O LYS A 214 1566 2493 1907 48 135 -57 O

ATOM 1424 CB LYS A 214 -1.715 5. ,176 -16. .821 1. .00 19. .92 C

ANISOU 1424 CB LYS A 214 2818 2975 1776 -178 - 130 -239 C

ATOM 1425 CG LYS A 214 -1.641 6. ,038 -15. .568 1. .00 25. .40 C

ANISOU 1425 CG LYS A 214 3581 3829 2240 -252 - 448 -763 C

ATOM 1426 CD LYS A 214 -0.302 5. ,949 -14. .859 1. .00 26. .47 c

ANISOU 1426 CD LYS A 214 3749 3654 2653 -320 - 704 - 1183 c

ATOM 1427 CE LYS A 214 -0.334 6. ,842 -13. .626 1. .00 23. .79 c

ANISOU 1427 CE LYS A 214 3338 3441 2258 -619 - 127 -880 c

ATOM 1428 NZ LYS A 214 0.924 6. .745 -12. .840 1. .00 28. .79 N

ANISOU 1428 NZ LYS A 214 2658 4782 3499 -685 107 -829 N

ATOM 1429 N ALA A 215 0.038 4. .526 -20. .009 1. .00 17. .07 N

ANISOU 1429 N ALA A 215 2058 2759 1669 300 27 -297 N

ATOM 1430 CA ALA A 215 -0.124 3. ,860 -21. .315 1. .00 14. .94 C

ANISOU 1430 CA ALA A 215 1766 2342 1565 526 439 -249 C

ATOM 1431 C ALA A 215 -0.427 2. ,364 -21. .246 1. .00 15. .69 C

ANISOU 1431 C ALA A 215 1573 2522 1866 367 215 -168 C

ATOM 1432 O ALA A 215 -0.823 1. ,772 -22. .249 1. .00 16. .83 O

ANISOU 1432 O ALA A 215 1556 2644 2193 -29 106 -335 O

ATOM 1433 CB ALA A 215 1.084 4. ,136 -22. .216 1. .00 14. .47 C

ANISOU 1433 CB ALA A 215 1843 2057 1597 553 467 10 C

ATOM 1434 N VAL A 216 -0.257 1. ,744 -20. .071 1. .00 15. .29 N

ANISOU 1434 N VAL A 216 1321 2631 1856 722 220 -255 N

ATOM 1435 CA VAL A 216 -0.697 0. ,349 -19. .875 1. .00 17. .39 C

ANISOU 1435 CA VAL A 216 1654 2757 2196 604 66 181 C

ATOM 1436 C VAL A 216 -2.209 0. ,207 -20. .198 1. .00 16. .51 C

ANISOU 1436 C VAL A 216 1695 2467 2108 467 92 -236 C

ATOM 1437 O VAL A 216 -2.700 -0. ,869 -20. .570 1. .00 17. .53 O

ANISOU 1437 O VAL A 216 1309 2654 2696 208 -18 -50 O

ATOM 1438 CB VAL A 216 -0.367 -0. ,126 -18. .441 1. .00 20. .55 C

ANISOU 1438 CB VAL A 216 2375 3374 2056 448 -62 68 C

ATOM 1439 CGI VAL A 216 -1.217 0. ,602 -17. .404 1. .00 18. .66 c

ANISOU 1439 CGI VAL A 216 1518 3426 2142 394 5 354 c

ATOM 1440 CG2 VAL A 216 -0.512 -1. ,628 -18. .299 1. .00 25. .02 c

ANISOU 1440 CG2 VAL A 216 2844 3362 3299 666 218 39 c

ATOM 1441 N ARG A 217 -2.939 1. ,312 -20. .081 1. .00 15. .79 N

ANISOU 1441 N ARG A 217 1815 2349 1836 420 -7 -222 N

ATOM 1442 CA ARG A 217 -4.396 1. ,298 -20. .321 1. .00 14. .92 C

ANISOU 1442 CA ARG A 217 1606 2473 1590 434 273 -481 C

ATOM 1443 C ARG A 217 -4.783 1. ,132 -21. .804 1. .00 14. .12 C

ANISOU 1443 C ARG A 217 1497 2144 1721 158 119 -420 C

ATOM 1444 O ARG A 217 -5.895 0. ,729 -22. .121 1. .00 15. .92 O

ANISOU 1444 O ARG A 217 1355 2650 2042 -87 396 -77 O

ATOM 1445 CB ARG A 217 -5.033 2. ,553 -19. .745 1. .00 16. .40 c

ANISOU 1445 CB ARG A 217 2162 2483 1586 176 550 -706 c

ATOM 1446 CG ARG A 217 -4.969 2. ,591 -18. .224 1. .00 18. .76 c

ANISOU 1446 CG ARG A 217 2379 3158 1588 403 206 -323 c

ATOM 1447 CD ARG A 217 -5.459 3. ,912 -17. .683 1. .00 20. .85 c

ANISOU 1447 CD ARG A 217 2861 2989 2070 224 -95 -546 c

ATOM 1448 NE ARG A 217 -5.186 4. ,008 -16. .253 1. .00 24. .70 N

ANISOU 1448 NE ARG A 217 2885 4443 2054 305 168 -582 N

ATOM 1449 CZ ARG A 217 -5.141 5. ,145 -15. .569 1. .00 22. .95 C ANISOU 1449 CZ ARG A 217 2588 3939 2191 325 397 ^■397 C

ATOM 1450 NH1 ARG A 217 -5.371 6. ,300 -16. .176 1. .00 21. .51 N

ANISOU 1450 NH1 ARG A 217 2219 3575 2378 495 282 863 N

ATOM 1451 NH2 ARG A 217 -4.869 5. ,125 -14. .271 1. .00 26. .09 N

ANISOU 1451 NH2 ARG A 217 2997 4696 2218 313 215 686 N

ATOM 1452 N LEU A 218 -3.842 1. ,428 -22. .697 1. .00 14. .05 N

ANISOU 1452 N LEU A 218 1646 2131 1560 236 91 ^■218 N

ATOM 1453 CA LEU A 218 -4.062 1. ,339 -24. .137 1. .00 12. .32 C

ANISOU 1453 CA LEU A 218 1171 1869 1638 251 - 124 51 C

ATOM 1454 C LEU A 218 -3.285 0. ,161 -24. .741 1. .00 13. .14 C

ANISOU 1454 C LEU A 218 1439 1951 1603 321 - 130 -28 C

ATOM 1455 O LEU A 218 -2.336 -0. ,348 -24. .120 1. .00 14. .35 O

ANISOU 1455 O LEU A 218 1246 2362 1841 457 - 238 ^■315 O

ATOM 1456 CB LEU A 218 -3.728 2. ,680 -24. .818 1. .00 13. .14 C

ANISOU 1456 CB LEU A 218 1216 1831 1945 268 193 108 C

ATOM 1457 CG LEU A 218 -4.768 3. ,809 -24. .600 1. .00 12. .51 C

ANISOU 1457 CG LEU A 218 1205 1439 2108 85 20 211 C

ATOM 1458 CD1 LEU A 218 -4.221 5. ,178 -25. .017 1. .00 12. .54 C

ANISOU 1458 CD1 LEU A 218 1331 1325 2109 94 - 198 94 C

ATOM 1459 CD2 LEU A 218 -6.076 3. ,486 -25. .336 1. .00 13. .72 C

ANISOU 1459 CD2 LEU A 218 1299 2024 1888 382 -69 8 C

ATOM 1460 N PRO A 219 -3.680 -0. ,299 -25. .938 1. .00 13. .12 N

ANISOU 1460 N PRO A 219 1312 2032 1637 503 - 184 ^■130 N

ATOM 1461 CA PRO A 219 -4.744 0. ,194 -26. .806 1. .00 12. .39 C

ANISOU 1461 CA PRO A 219 1025 2060 1621 249 - 209 ^■222 C

ATOM 1462 C PRO A 219 -6.173 -0. ,233 -26. .394 1. .00 13. .20 C

ANISOU 1462 C PRO A 219 1108 2175 1730 136 - 271 127 C

ATOM 1463 O PRO A 219 -6.386 -1. ,026 -25. .464 1. .00 14. .01 O

ANISOU 1463 O PRO A 219 1557 1882 1884 83 - 357 38 O

ATOM 1464 CB PRO A 219 -4.388 -0. ,428 -28. .157 1. .00 14. .69 C

ANISOU 1464 CB PRO A 219 1775 1995 1808 422 38 ^■197 C

ATOM 1465 CG PRO A 219 -3.750 -1. ,734 -27. .779 1. .00 15. .03 C

ANISOU 1465 CG PRO A 219 1722 2025 1962 413 - 262 ^■332 c

ATOM 1466 CD PRO A 219 -2.895 -1. ,363 -26. .599 1. .00 15. .43 c

ANISOU 1466 CD PRO A 219 1821 2330 1709 688 - 227 ^■404 c

ATOM 1467 N ILE A 220 -7.138 0. ,318 -27. .111 1. .00 12. .79 N

ANISOU 1467 N ILE A 220 1098 1916 1846 248 - 244 49 N

ATOM 1468 CA ILE A 220 -8.544 -0. ,070 -26. .979 1. .00 12. .91 C

ANISOU 1468 CA ILE A 220 1285 1814 1806 50 -14 114 C

ATOM 1469 C ILE A 220 -8.748 -1. ,446 -27. .617 1. .00 13. .98 C

ANISOU 1469 C ILE A 220 1585 1713 2011 117 44 73 C

ATOM 1470 O ILE A 220 -8.285 -1. ,681 -28. .746 1. .00 16. .28 O

ANISOU 1470 O ILE A 220 1854 2185 2143 134 226 -97 O

ATOM 1471 CB ILE A 220 -9.423 0. ,964 -27. .706 1. .00 12. .13 c

ANISOU 1471 CB ILE A 220 1034 1596 1978 41 151 188 c

ATOM 1472 CGI ILE A 220 -9.346 2. ,306 -26. .957 1. .00 12. .73 c

ANISOU 1472 CGI ILE A 220 1090 1790 1956 -34 211 16 c

ATOM 1473 CG2 ILE A 220 -10.881 0. ,492 -27. .800 1. .00 12. .72 c

ANISOU 1473 CG2 ILE A 220 1153 1535 2141 -62 - 267 242 c

ATOM 1474 CD1 ILE A 220 -9.800 3. ,499 -27. .763 1. .00 14. .70 c

ANISOU 1474 CD1 ILE A 220 1537 2263 1784 193 638 302 c

ATOM 1475 N VAL A 221 -9.446 -2. ,347 -26. .916 1. .00 14. .56 N

ANISOU 1475 N VAL A 221 1568 1665 2300 -15 - 302 192 N

ATOM 1476 CA VAL A 221 -9.646 -3. ,704 -27. .442 1. .00 15. .33 C

ANISOU 1476 CA VAL A 221 1631 1694 2497 66 -69 39 C

ATOM 1477 C VAL A 221 -11.106 -4. ,063 -27. .712 1. .00 15. .23 C

ANISOU 1477 C VAL A 221 1624 2053 2107 97 - 147 -93 C

ATOM 1478 O VAL A 221 -11.375 -5. ,058 -28. .388 1. .00 14. .94 0

ANISOU 1478 O VAL A 221 1067 1929 2679 48 15 ^■121 0

ATOM 1479 CB VAL A 221 -9.006 -4. ,802 -26. .552 1. .00 16. .35 c

ANISOU 1479 CB VAL A 221 1577 2159 2477 387 -48 126 c ATOM 1480 CGI VAL A 221 -7.488 -4..640 -26..468 1..00 18..02 C

ANISOU 1480 CGI VAL A 221 1548 2348 2950 307 2 282 C

ATOM 1481 CG2 VAL A 221 -9.613 -4. .833 -25. .163 1. .00 16. .37 C

ANISOU 1481 CG2 VAL A 221 1791 2006 2420 435 -11 316 C

ATOM 1482 N ASP A 222 -12.044 -3. .284 -27. .184 1. .00 12. .97 N

ANISOU 1482 N ASP A 222 1261 1753 1911 -36 -56 424 N

ATOM 1483 CA ASP A 222 -13.466 -3. .568 -27. .442 1. .00 13. .59 C

ANISOU 1483 CA ASP A 222 1271 1761 2130 44 48 129 C

ATOM 1484 C ASP A 222 -14.318 -2. .302 -27. .323 1. .00 13. .44 C

ANISOU 1484 C ASP A 222 1419 1809 1875 52 433 ^■136 C

ATOM 1485 O ASP A 222 -13.854 -1. .262 -26. .844 1. .00 12. .57 O

ANISOU 1485 O ASP A 222 1386 1736 1654 68 130 19 O

ATOM 1486 CB ASP A 222 -13.979 -4. .675 -26. .515 1. .00 14. .82 C

ANISOU 1486 CB ASP A 222 1726 1517 2388 5 -76 166 C

ATOM 1487 CG ASP A 222 -15.081 -5. .515 -27. .144 1. .00 16. .73 C

ANISOU 1487 CG ASP A 222 2254 1715 2385 -259 - 121 144 c

ATOM 1488 OD1 ASP A 222 -15.737 -5. .073 -28. .112 1. .00 17. .55 0

ANISOU 1488 OD1 ASP A 222 1433 2682 2554 -87 -32 236 0

ATOM 1489 OD2 ASP A 222 -15.306 -6. .633 -26. .647 1. .00 19. .11 0

ANISOU 1489 OD2 ASP A 222 2469 1775 3016 -345 170 295 0

ATOM 1490 N ILE A 223 -15.558 -2. .403 -27. .800 1. .00 14. .40 N

ANISOU 1490 N ILE A 223 1605 1817 2046 176 136 -38 N

ATOM 1491 CA ILE A 223 -16.512 -1. .296 -27. .777 1. .00 13. .17 C

ANISOU 1491 CA ILE A 223 1528 1608 1868 36 152 46 C

ATOM 1492 C ILE A 223 -17.887 -1. .852 -27. .409 1. .00 13. .45 C

ANISOU 1492 C ILE A 223 1510 1814 1786 -34 -41 19 C

ATOM 1493 O ILE A 223 -18.275 -2. .908 -27. .915 1. .00 14. .67 O

ANISOU 1493 O ILE A 223 1459 1757 2355 6 213 ^■124 0

ATOM 1494 CB ILE A 223 -16.514 -0. .521 -29. .126 1. .00 12. .12 c

ANISOU 1494 CB ILE A 223 1578 1508 1517 144 - 133 ^■292 c

ATOM 1495 CGI ILE A 223 -17.408 0. .723 -29. .031 1. .00 13. .67 c

ANISOU 1495 CGI ILE A 223 2026 1358 1807 183 219 78 c

ATOM 1496 CG2 ILE A 223 -16.912 -1. .431 -30. .298 1. .00 11. .69 c

ANISOU 1496 CG2 ILE A 223 1540 1267 1631 4 132 ^■376 c

ATOM 1497 CD1 ILE A 223 -17.278 1. .669 -30. .204 1. .00 14. .32 c

ANISOU 1497 CD1 ILE A 223 1885 1976 1580 334 - 230 275 c

ATOM 1498 N ALA A 224 -18.577 -1. .166 -26. .493 1. .00 15. .81 N

ANISOU 1498 N ALA A 224 1579 2215 2213 -19 395 37 N

ATOM 1499 CA ALA A 224 -19.936 -1. .527 -26. .072 1. .00 15. .75 C

ANISOU 1499 CA ALA A 224 1585 2465 1933 -331 109 54 C

ATOM 1500 C ALA A 224 -20.908 -0. .383 -26. .331 1. .00 15. .25 C

ANISOU 1500 C ALA A 224 1690 2251 1854 -372 146 ^■107 C

ATOM 1501 O ALA A 224 -21.046 0. .522 -25. .505 1. .00 14. .58 0

ANISOU 1501 O ALA A 224 1798 1711 2030 -393 13 124 0

ATOM 1502 CB ALA A 224 -19.983 -1. .939 -24. .596 1. .00 14. .97 c

ANISOU 1502 CB ALA A 224 1585 1933 2167 32 352 301 c

ATOM 1503 N PRO A 225 -21.609 -0. .422 -27. .480 1. .00 14. .26 N

ANISOU 1503 N PRO A 225 1501 2231 1683 -345 312 135 N

ATOM 1504 CA PRO A 225 -22.704 0. .525 -27. .689 1. .00 15. .46 C

ANISOU 1504 CA PRO A 225 1582 2392 1899 -294 88 194 C

ATOM 1505 C PRO A 225 -23.890 0. .199 -26. .775 1. .00 14. .39 C

ANISOU 1505 C PRO A 225 1274 2204 1987 -161 -26 30 C

ATOM 1506 O PRO A 225 -24.009 -0. .937 -26. .298 1. .00 17. .41 O

ANISOU 1506 O PRO A 225 1921 2248 2444 -396 - 201 97 0

ATOM 1507 CB PRO A 225 -23.103 0. .286 -29. .150 1. .00 17. .13 c

ANISOU 1507 CB PRO A 225 1752 2735 2019 -38 154 ^■440 c

ATOM 1508 CG PRO A 225 -22.008 -0. .516 -29. .775 1. .00 16. .63 c

ANISOU 1508 CG PRO A 225 976 2713 2628 0 -81 52 c

ATOM 1509 CD PRO A 225 -21.402 -1. .302 -28. .648 1. .00 15. .66 c

ANISOU 1509 CD PRO A 225 1766 2003 2178 -60 29 ^■144 c

ATOM 1510 N TYR A 226 -24.745 1. .193 -26. .528 1. .00 17. .44 N ANISOU 1510 N TYR A 226 1527 2734 2364 95 216 -178 N

ATOM 1511 CA TYR A 226 -25.916 1 028 -25.677 1 00 15.42 C

ANISOU 1511 CA TYR A 226 1944 2303 1608 -137 169 -174 C

ATOM 1512 C TYR A 226 -27.184 1 144 -26.534 1 00 16.05 C

ANISOU 1512 C TYR A 226 1669 2213 2213 -227 216 -142 C

ATOM 1513 O TYR A 226 -28.082 0 291 -26.466 1 00 16.91 O

ANISOU 1513 O TYR A 226 1291 2824 2311 -318 185 -374 O

ATOM 1514 CB TYR A 226 -25.882 2 087 -24.560 1 00 16.51 C

ANISOU 1514 CB TYR A 226 2011 1919 2344 -233 229 -348 C

ATOM 1515 CG TYR A 226 -27.082 2 114 -23.642 1 00 21.68 C

ANISOU 1515 CG TYR A 226 2703 2856 2678 -24 754 -76 C

ATOM 1516 CD1 TYR A 226 -28.242 2 805 -23.998 1 00 22.24 C

ANISOU 1516 CD1 TYR A 226 1925 3248 3278 -392 787 -399 C

ATOM 1517 CD2 TYR A 226 -27.051 1 463 -22.404 1 00 23.45 C

ANISOU 1517 CD2 TYR A 226 2328 3788 2792 -801 370 193 C

ATOM 1518 CE1 TYR A 226 -29.341 2 841 -23.145 1 00 25.81 C

ANISOU 1518 CE1 TYR A 226 2563 3170 4074 241 1487 -162 C

ATOM 1519 CE2 TYR A 226 -28.138 1 497 -21.550 1 00 26.10 C

ANISOU 1519 CE2 TYR A 226 2893 3312 3711 -403 1082 285 C

ATOM 1520 CZ TYR A 226 -29.275 2 185 -21.928 1 00 27.72 C

ANISOU 1520 CZ TYR A 226 3341 3110 4081 214 1240 -212 C

ATOM 1521 OH TYR A 226 -30.351 2 221 -21.088 1 00 38.93 O

ANISOU 1521 OH TYR A 226 4773 5126 4892 -793 2383 389 O

ATOM 1522 N ASP A 227 -27.233 2 178 -27.370 1 00 14.43 N

ANISOU 1522 N ASP A 227 1440 2348 1694 -313 -47 -138 N

ATOM 1523 CA ASP A 227 -28.415 2 454 -28.170 1 00 16.70 C

ANISOU 1523 CA ASP A 227 1627 2651 2066 -129 -151 -60 C

ATOM 1524 C ASP A 227 -28.442 1 663 -29.490 1 00 15.71 C

ANISOU 1524 C ASP A 227 1329 2166 2474 4 -134 -298 C

ATOM 1525 O ASP A 227 -28.314 2 225 -30.577 1 00 17.59 O

ANISOU 1525 O ASP A 227 1317 2886 2478 -314 -352 -157 O

ATOM 1526 CB ASP A 227 -28.569 3 963 -28.408 1 00 16.56 C

ANISOU 1526 CB ASP A 227 2165 2716 1408 121 -64 7 C

ATOM 1527 CG ASP A 227 -29.883 4 308 -29.064 1 00 18.53 C

ANISOU 1527 CG ASP A 227 1743 3083 2215 -89 -90 -307 C

ATOM 1528 OD1 ASP A 227 -30.888 3 596 -28.804 1 00 17.82 O

ANISOU 1528 OD1 ASP A 227 1383 3174 2212 121 -410 -77 O

ATOM 1529 OD2 ASP A 227 -29.909 5 276 -29.852 1 00 20.22 O

ANISOU 1529 OD2 ASP A 227 1351 3357 2973 -170 -435 19 O

ATOM 1530 N ILE A 228 -28.631 0 357 -29.366 1 00 16.58 N

ANISOU 1530 N ILE A 228 1316 2235 2748 -323 -248 -349 N

ATOM 1531 CA ILE A 228 -28.579 -0 584 -30.487 1 00 17.66 C

ANISOU 1531 CA ILE A 228 1601 2324 2784 -524 -419 -502 C

ATOM 1532 C ILE A 228 -29.608 -1 690 -30.231 1 00 18.91 C

ANISOU 1532 C ILE A 228 1883 2327 2974 -549 -259 -393 C

ATOM 1533 O ILE A 228 -30.143 -1 793 -29.121 1 00 20.68 O

ANISOU 1533 O ILE A 228 1793 2789 3273 -843 -319 67 O

ATOM 1534 CB ILE A 228 -27.180 -1 232 -30.647 1 00 20.34 C

ANISOU 1534 CB ILE A 228 1887 2611 3228 -312 -267 -214 C

ATOM 1535 CGI ILE A 228 -26.728 -1 876 -29.326 1 00 19.57 C

ANISOU 1535 CGI ILE A 228 2032 2180 3222 93 -284 -368 C

ATOM 1536 CG2 ILE A 228 -26.169 -0 215 -31.174 1 00 18.89 C

ANISOU 1536 CG2 ILE A 228 1855 2681 2640 -501 29 -835 C

ATOM 1537 CD1 ILE A 228 -25.552 -2 827 -29.464 1 00 19.13 C

ANISOU 1537 CD1 ILE A 228 1754 2218 3294 -158 9 -635 C

ATOM 1538 N GLY A 229 -29.899 -2 496 -31.245 1 00 19.11 N

ANISOU 1538 N GLY A 229 1889 1655 3717 -647 -410 -564 N

ATOM 1539 CA GLY A 229 -30.793 -3 633 -31.072 1 00 20.69 C

ANISOU 1539 CA GLY A 229 1851 2396 3610 -1068 -691 -245 C

ATOM 1540 C GLY A 229 -32.127 -3 504 -31.779 1 00 22.39 C

ANISOU 1540 C GLY A 229 1285 2904 4316 -959 -324 -389 C ATOM 1541 O GLY A 229 -32.740 -4 513 -32.102 1.00 26.82 O

ANISOU 1541 O GLY A 229 2537 3302 4351 -1446 -553 -614 O

ATOM 1542 N GLY A 230 -32.578 -2 269 -32.017 1.00 23.04 N

ANISOU 1542 N GLY A 230 1934 2913 3903 -859 -894 -892 N

ATOM 1543 CA GLY A 230 -33.840 -2 025 -32.725 1.00 25.14 C

ANISOU 1543 CA GLY A 230 1743 3657 4152 -871 -696 -456 C

ATOM 1544 C GLY A 230 -33.685 -2 301 -34.213 1.00 28.68 C

ANISOU 1544 C GLY A 230 2383 4400 4112 -1334 -700 -288 C

ATOM 1545 O GLY A 230 -32.565 -2 283 -34.727 1.00 24.19 O

ANISOU 1545 O GLY A 230 2108 3970 3113 -859 -1148 -100 O

ATOM 1546 N PRO A 231 -34.808 -2 542 -34.920 1.00 33.37 N

ANISOU 1546 N PRO A 231 3200 5657 3822 -1616 -1181 3 N

ATOM 1547 CA PRO A 231 -34.770 -2 981 -36.326 1.00 32.48 C

ANISOU 1547 CA PRO A 231 3070 5324 3945 -2067 -581 -210 C

ATOM 1548 C PRO A 231 -34.057 -2 029 -37.297 1.00 27.25 C

ANISOU 1548 C PRO A 231 2394 4841 3116 -1315 8 -967 C

ATOM 1549 O PRO A 231 -33.521 -2 492 -38.306 1.00 31.65 O

ANISOU 1549 O PRO A 231 3658 4584 3783 -799 271 -1691 O

ATOM 1550 CB PRO A 231 -36.257 -3 116 -36.708 1.00 36.33 C

ANISOU 1550 CB PRO A 231 3194 6050 4557 -1403 -1138 -291 C

ATOM 1551 CG PRO A 231 -37.019 -2 393 -35.645 1.00 36.69 C

ANISOU 1551 CG PRO A 231 2802 6499 4636 -2060 -615 -377 C

ATOM 1552 CD PRO A 231 -36.185 -2 474 -34.399 1.00 37.19 C

ANISOU 1552 CD PRO A 231 3012 6031 5087 -906 -1001 -453 C

ATOM 1553 N ASP A 232 -34.065 -0 727 -37.007 1.00 29.15 N

ANISOU 1553 N ASP A 232 2504 4183 4387 -924 -790 -86 N

ATOM 1554 CA ASP A 232 -33.488 0 273 -37.923 1.00 27.39 C

ANISOU 1554 CA ASP A 232 2457 3640 4310 -1072 -1316 -258 C

ATOM 1555 C ASP A 232 -32.183 0 884 -37.413 1.00 23.45 C

ANISOU 1555 C ASP A 232 2461 3270 3179 -824 -1075 -722 C

ATOM 1556 O ASP A 232 -31.711 1 887 -37.961 1.00 21.63 O

ANISOU 1556 O ASP A 232 1594 3402 3219 -517 -1072 -584 O

ATOM 1557 CB ASP A 232 -34.506 1 379 -38.244 1.00 32.13 C

ANISOU 1557 CB ASP A 232 3527 3874 4805 -397 -1271 137 C

ATOM 1558 CG ASP A 232 -35.729 0 853 -38.988 1.00 35.25 C

ANISOU 1558 CG ASP A 232 3942 3797 5652 -311 -1677 -74 C

ATOM 1559 OD1 ASP A 232 -35.634 -0 211 -39.646 1.00 41.22 O

ANISOU 1559 OD1 ASP A 232 5244 4045 6371 -1208 -2362 -650 O

ATOM 1560 OD2 ASP A 232 -36.794 1 508 -38.923 1.00 42.95 O

ANISOU 1560 OD2 ASP A 232 3142 6110 7066 -266 -3158 -445 O

ATOM 1561 N GLN A 233 -31.618 0 270 -36.374 1.00 21.22 N

ANISOU 1561 N GLN A 233 1698 3183 3181 -937 -894 -441 N

ATOM 1562 CA GLN A 233 -30.388 0 754 -35.728 1.00 19.39 C

ANISOU 1562 CA GLN A 233 1624 3181 2559 -765 -687 -687 C

ATOM 1563 C GLN A 233 -29.206 0 002 -36.304 1.00 21.67 C

ANISOU 1563 C GLN A 233 1760 3237 3235 -260 -772 -227 C

ATOM 1564 O GLN A 233 -29.234 -1 236 -36.412 1.00 22.62 O

ANISOU 1564 O GLN A 233 1697 3242 3656 -964 169 60 O

ATOM 1565 CB GLN A 233 -30.449 0 539 -34.221 1.00 17.43 C

ANISOU 1565 CB GLN A 233 1014 2955 2653 -287 -121 -797 C

ATOM 1566 CG GLN A 233 -31.634 1 243 -33.559 1.00 16.30 C

ANISOU 1566 CG GLN A 233 1155 2721 2314 -515 222 -671 C

ATOM 1567 CD GLN A 233 -31.500 1 276 -32.054 1.00 19.27 C

ANISOU 1567 CD GLN A 233 1766 3093 2461 -461 -529 -265 C

ATOM 1568 OE1 GLN A 233 -31.652 0 258 -31.377 1.00 21.30 O

ANISOU 1568 OE1 GLN A 233 2233 2588 3271 -657 -783 -448 O

ATOM 1569 NE2 GLN A 233 -31.233 2 451 -31.521 1.00 18.78 N

ANISOU 1569 NE2 GLN A 233 1510 2776 2847 -519 -274 16 N

ATOM 1570 N GLU A 234 -28.187 0 756 -36.710 1.00 21.51 N

ANISOU 1570 N GLU A 234 1354 3636 3181 -243 -655 -681 N

ATOM 1571 CA GLU A 234 -26.971 0 180 -37.263 1.00 19.19 C ANISOU 1571 CA GLU A 234 1491 2837 2961 -466 -414 -537 C

ATOM 1572 C GLU A 234 -25.749 0 924 -36.770 1 00 16.69 C

ANISOU 1572 C GLU A 234 1719 2314 2308 -263 -440 -831 C

ATOM 1573 O GLU A 234 -25.822 2 108 -36.453 1 00 17.02 O

ANISOU 1573 O GLU A 234 1705 2142 2618 -9 -318 -510 O

ATOM 1574 CB GLU A 234 -26.997 0 219 -38.788 1 00 23.49 C

ANISOU 1574 CB GLU A 234 2195 3793 2936 -197 -677 -1144 C

ATOM 1575 CG GLU A 234 -28.122 -0 598 -39.416 1 00 23.50 C

ANISOU 1575 CG GLU A 234 1586 3751 3592 84 -592 -1230 C

ATOM 1576 CD GLU A 234 -28.000 -0 680 -40.915 1 00 29.49 C

ANISOU 1576 CD GLU A 234 2623 5014 3567 109 -1032 -1669 C

ATOM 1577 OE1 GLU A 234 -26.910 -1 027 -41.426 1 00 30.82 O

ANISOU 1577 OE1 GLU A 234 2764 5312 3634 630 -1213 -2134 O

ATOM 1578 OE2 GLU A 234 -29.004 -0 408 -41.585 1 00 32.40 O

ANISOU 1578 OE2 GLU A 234 2791 5447 4072 547 -911 -1058 O

ATOM 1579 N PHE A 235 -24.621 0 227 -36.719 1 00 17.35 N

ANISOU 1579 N PHE A 235 1600 2513 2478 -242 -360 -667 N

ATOM 1580 CA PHE A 235 -23.349 0 900 -36.452 1 00 16.37 C

ANISOU 1580 CA PHE A 235 1607 2221 2391 -162 -348 -502 C

ATOM 1581 C PHE A 235 -22.180 0 250 -37.186 1 00 17.84 C

ANISOU 1581 C PHE A 235 1890 2090 2795 190 -300 -455 C

ATOM 1582 O PHE A 235 -22.259 -0 915 -37.605 1 00 18.19 O

ANISOU 1582 O PHE A 235 1945 2523 2442 -275 -673 -902 O

ATOM 1583 CB PHE A 235 -23.078 0 988 -34.947 1 00 18.05 C

ANISOU 1583 CB PHE A 235 1845 2635 2378 216 -298 -276 C

ATOM 1584 CG PHE A 235 -22.612 -0 302 -34.321 1 00 19.08 C

ANISOU 1584 CG PHE A 235 2271 2604 2374 414 -107 -379 C

ATOM 1585 CD1 PHE A 235 -21.250 -0 607 -34.256 1 00 17.36 C

ANISOU 1585 CD1 PHE A 235 2188 2298 2109 275 -517 -431 C

ATOM 1586 CD2 PHE A 235 -23.524 -1 189 -33.749 1 00 19.01 C

ANISOU 1586 CD2 PHE A 235 2365 2241 2617 213 -314 -488 C

ATOM 1587 CE1 PHE A 235 -20.816 -1 779 -33.657 1 00 19.54 C

ANISOU 1587 CE1 PHE A 235 2676 2157 2590 -4 -194 -6 C

ATOM 1588 CE2 PHE A 235 -23.095 -2 368 -33.143 1 00 17.90 C

ANISOU 1588 CE2 PHE A 235 1880 2337 2583 -146 -345 -289 C

ATOM 1589 CZ PHE A 235 -21.737 -2 669 -33.101 1 00 17.31 C

ANISOU 1589 CZ PHE A 235 2058 2200 2317 244 -664 267 C

ATOM 1590 N GLY A 236 -21.112 1 027 -37.342 1 00 16.33 N

ANISOU 1590 N GLY A 236 1884 1956 2362 283 -302 -160 N

ATOM 1591 CA GLY A 236 -19.799 0 522 -37.744 1 00 17.03 C

ANISOU 1591 CA GLY A 236 1529 2557 2381 -424 -17 -469 C

ATOM 1592 C GLY A 236 -18.735 1 222 -36.909 1 00 15.52 C

ANISOU 1592 C GLY A 236 1573 2220 2103 -71 -264 -265 C

ATOM 1593 O GLY A 236 -19.031 2 155 -36.168 1 00 15.78 O

ANISOU 1593 O GLY A 236 1530 2434 2032 81 -300 -351 O

ATOM 1594 N VAL A 237 -17.492 0 763 -37.015 1 00 15.24 N

ANISOU 1594 N VAL A 237 1516 2242 2033 -207 -17 -202 N

ATOM 1595 CA VAL A 237 -16.387 1 365 -36.260 1 00 14.20 C

ANISOU 1595 CA VAL A 237 1306 2195 1893 21 -50 -172 C

ATOM 1596 C VAL A 237 -15.135 1 521 -37.132 1 00 14.52 C

ANISOU 1596 C VAL A 237 1556 2096 1863 -285 -4 2 C

ATOM 1597 O VAL A 237 -14.822 0 651 -37.965 1 00 17.84 O

ANISOU 1597 O VAL A 237 1731 2183 2865 -375 -70 -573 O

ATOM 1598 CB VAL A 237 -16.020 0 524 -35.008 1 00 13.65 C

ANISOU 1598 CB VAL A 237 1474 1764 1946 -213 72 -194 C

ATOM 1599 CGI VAL A 237 -15.109 1 312 -34.094 1 00 17.08 C

ANISOU 1599 CGI VAL A 237 2164 2241 2083 -335 -398 -159 C

ATOM 1600 CG2 VAL A 237 -17.259 0 105 -34.224 1 00 15.80 C

ANISOU 1600 CG2 VAL A 237 1415 2339 2249 -372 182 -386 C

ATOM 1601 N ASP A 238 -14.427 2 630 -36.942 1 00 14.34 N

ANISOU 1601 N ASP A 238 1519 1823 2106 -114 119 6 N ATOM 1602 CA ASP A 238 -13.079 2..770 -37..501 1..00 15., 08 C

ANISOU 1602 CA ASP A 238 1440 2009 2278 -360 -60 20 C

ATOM 1603 C ASP A 238 -12.122 2. .932 -36. .334 1. .00 14. , 45 C

ANISOU 1603 C ASP A 238 1830 1474 2186 -102 - 169 153 C

ATOM 1604 O ASP A 238 -12.229 3. .904 -35. .583 1. .00 15. , 64 O

ANISOU 1604 O ASP A 238 1816 2071 2053 -400 -13 -164 O

ATOM 1605 CB ASP A 238 -12.988 3. .979 -38. .432 1. .00 18. , 65 C

ANISOU 1605 CB ASP A 238 2150 2687 2248 100 - 152 496 C

ATOM 1606 CG ASP A 238 -13.744 3. .777 -39. .733 1. .00 25. , 18 C

ANISOU 1606 CG ASP A 238 3863 3613 2089 -153 - 311 412 C

ATOM 1607 OD1 ASP A 238 -13.893 2. .628 -40. .195 1. .00 34. , 50 O

ANISOU 1607 OD1 ASP A 238 5524 4667 2917 -1366 -1360 -463 O

ATOM 1608 OD2 ASP A 238 -14.188 4. .781 -40. .308 1. .00 29. , 62 O

ANISOU 1608 OD2 ASP A 238 3713 4702 2837 861 594 1093 O

ATOM 1609 N VAL A 239 -11.190 1. .995 -36. .179 1. .00 13. , 64 N

ANISOU 1609 N VAL A 239 1186 2077 1919 -12 - 164 -60 N

ATOM 1610 CA VAL A 239 -10.310 2. .001 -35. .014 1. .00 12. , 92 C

ANISOU 1610 CA VAL A 239 879 2084 1946 -40 -25 -390 C

ATOM 1611 C VAL A 239 -9.063 2. .767 -35. .400 1. .00 13. , 64 C

ANISOU 1611 C VAL A 239 1385 1835 1963 -269 -1 -314 C

ATOM 1612 O VAL A 239 -8.371 2. .369 -36. .323 1. .00 16. , 17 O

ANISOU 1612 O VAL A 239 1642 2436 2063 23 141 -422 O

ATOM 1613 CB VAL A 239 -9.938 0. .566 -34. .576 1. .00 14. , 45 C

ANISOU 1613 CB VAL A 239 1215 2352 1922 -126 - 192 130 C

ATOM 1614 CGI VAL A 239 -9.000 0. .595 -33. .371 1. .00 14. ,76 c

ANISOU 1614 CGI VAL A 239 1139 2618 1849 138 - 142 -115 c

ATOM 1615 CG2 VAL A 239 -11.196 -0. .223 -34. .253 1. .00 13. , 98 c

ANISOU 1615 CG2 VAL A 239 1665 1918 1728 -239 211 -215 c

ATOM 1616 N GLY A 240 -8.788 3. .870 -34. .703 1. .00 13. , 80 N

ANISOU 1616 N GLY A 240 1527 1950 1764 -214 - 311 -374 N

ATOM 1617 CA GLY A 240 -7.598 4. .656 -34. .996 1. .00 14. , 05 C

ANISOU 1617 CA GLY A 240 1637 1828 1872 -164 - 383 75 C

ATOM 1618 C GLY A 240 -6.342 3. .977 -34. .461 1. .00 13. , 30 C

ANISOU 1618 C GLY A 240 1335 1796 1921 35 -52 -339 C

ATOM 1619 O GLY A 240 -6.422 3. .090 -33. .606 1. .00 13. , 96 O

ANISOU 1619 O GLY A 240 960 2228 2114 -59 - 134 -110 O

ATOM 1620 N PRO A 241 -5.166 4. .373 -34. .971 1. .00 13. , 43 N

ANISOU 1620 N PRO A 241 1426 1826 1849 -61 - 226 74 N

ATOM 1621 CA PRO A 241 -3.956 3. .747 -34. .435 1. .00 13. , 10 C

ANISOU 1621 CA PRO A 241 1209 2054 1714 100 -8 -151 C

ATOM 1622 C PRO A 241 -3.700 4. .134 -32. .979 1. .00 13. , 62 C

ANISOU 1622 C PRO A 241 1425 1873 1877 376 - 138 -430 C

ATOM 1623 O PRO A 241 -4.064 5. .238 -32. .549 1. .00 12. , 48 O

ANISOU 1623 O PRO A 241 1202 1934 1603 302 - 230 -600 O

ATOM 1624 CB PRO A 241 -2.819 4. .304 -35. .319 1. .00 14. , 24 C

ANISOU 1624 CB PRO A 241 1305 2212 1892 -3 -84 262 C

ATOM 1625 CG PRO A 241 -3.395 5. .421 -36. .105 1. .00 19. , 10 c

ANISOU 1625 CG PRO A 241 2056 1983 3218 -3 -20 702 c

ATOM 1626 CD PRO A 241 -4.901 5. .331 -36. .064 1. .00 16. , 25 c

ANISOU 1626 CD PRO A 241 2036 1912 2226 -425 -94 248 c

ATOM 1627 N VAL A 242 -3.086 3. .233 -32. .223 1. .00 12. , 99 N

ANISOU 1627 N VAL A 242 1642 1775 1518 39 -81 -294 N

ATOM 1628 CA VAL A 242 -2.639 3. .601 -30. .890 1. .00 12. , 37 C

ANISOU 1628 CA VAL A 242 1491 2022 1183 131 145 -131 C

ATOM 1629 C VAL A 242 -1.257 4. .260 -31. .008 1. .00 14. , 85 C

ANISOU 1629 C VAL A 242 1625 1997 2019 -23 -23 -670 C

ATOM 1630 O VAL A 242 -0.347 3. .719 -31. .677 1. .00 15. , 66 O

ANISOU 1630 O VAL A 242 1699 2231 2017 183 200 -48 O

ATOM 1631 CB VAL A 242 -2.661 2. .390 -29. .923 1. .00 14. , 60 c

ANISOU 1631 CB VAL A 242 2067 1859 1621 225 102 -137 c

ATOM 1632 CGI VAL A 242 -1.838 1. .238 -30. .474 1. .00 15. , 97 c ANISOU 1632 CGI VAL A 242 1879 2427 1760 318 440 -323 C

ATOM 1633 CG2 VAL A 242 -2.207 2. ,789 -28. .521 1. .00 15. .16 C

ANISOU 1633 CG2 VAL A 242 1542 2546 1669 156 280 -443 C

ATOM 1634 N CYS A 243 -1.121 5. ,443 -30. .404 1. .00 13. .60 N

ANISOU 1634 N CYS A 243 1504 1775 1886 31 -48 -417 N

ATOM 1635 CA CYS A 243 0.091 6. .235 -30. .536 1. .00 13. .78 C

ANISOU 1635 CA CYS A 243 1288 2357 1589 52 - 135 -186 C

ATOM 1636 C CYS A 243 0.765 6. .438 -29. .200 1. .00 12. .14 C

ANISOU 1636 C CYS A 243 1282 1950 1379 53 41 -151 C

ATOM 1637 O CYS A 243 0.152 6. .952 -28. .262 1. .00 13. .71 O

ANISOU 1637 O CYS A 243 1294 2300 1615 324 0 -282 O

ATOM 1638 CB CYS A 243 -0.191 7. ,596 -31. .189 1. .00 18. .15 C

ANISOU 1638 CB CYS A 243 2339 2717 1840 296 - 503 73 C

ATOM 1639 SG CYS A 243 -0.740 7. ,521 -32. .924 1. .00 19. .10 s

ANISOU 1639 SG CYS A 243 2722 2611 1920 674 - 735 -255 s

ATOM 1640 N PHE A 244 2.036 6. .057 -29. .146 1. .00 12. .83 N

ANISOU 1640 N PHE A 244 1351 1770 1752 145 - 177 95 N

ATOM 1641 CA PHE A 244 2.854 6. .099 -27. .935 1. .00 12. .36 C

ANISOU 1641 CA PHE A 244 1829 1582 1285 278 32 168 C

ATOM 1642 C PHE A 244 3.943 7. .159 -28. .048 1. .00 15. .50 C

ANISOU 1642 C PHE A 244 1971 1976 1941 42 -62 -124 C

ATOM 1643 O PHE A 244 4.605 7. ,284 -29. .097 1. .00 16. .59 O

ANISOU 1643 O PHE A 244 2182 2283 1835 -50 - 122 146 O

ATOM 1644 CB PHE A 244 3.547 4. .752 -27. .722 1. .00 12. .37 C

ANISOU 1644 CB PHE A 244 1553 1486 1658 180 29 49 c

ATOM 1645 CG PHE A 244 2.605 3. .606 -27. .498 1. .00 12. .56 c

ANISOU 1645 CG PHE A 244 1451 1653 1667 132 - 110 5 c

ATOM 1646 CD1 PHE A 244 2.054 3. .377 -26. .233 1. .00 13. .32 c

ANISOU 1646 CD1 PHE A 244 1057 1928 2073 197 144 352 c

ATOM 1647 CD2 PHE A 244 2.285 2. .739 -28. .539 1. .00 11. .85 c

ANISOU 1647 CD2 PHE A 244 999 1499 2003 89 - 428 40 c

ATOM 1648 CE1 PHE A 244 1.210 2. .302 -26. .016 1. .00 12. .55 c

ANISOU 1648 CE1 PHE A 244 1260 1462 2046 228 - 385 53 c

ATOM 1649 CE2 PHE A 244 1.437 1. ,664 -28. .320 1. .00 11. .94 c

ANISOU 1649 CE2 PHE A 244 1095 1652 1790 -3 - 141 -86 c

ATOM 1650 CZ PHE A 244 0.905 1. .442 -27. .061 1. .00 12. .76 c

ANISOU 1650 CZ PHE A 244 1203 1905 1740 17 - 146 13 c

ATOM 1651 N LEU A 245 4.158 7. .900 -26. .974 1. .00 17. .95 N

ANISOU 1651 N LEU A 245 2914 1880 2024 -185 - 288 -56 N

ATOM 1652 CA LEU A 245 5.236 8. .873 -26. .962 1. .00 18. .58 C

ANISOU 1652 CA LEU A 245 2663 1841 2556 -93 20 12 c

ATOM 1653 C LEU A 245 6.416 8. .392 -26. .103 1. .00 24. .50 c

ANISOU 1653 C LEU A 245 3609 2982 2716 -258 - 561 343 c

ATOM 1654 O LEU A 245 7.396 7. .806 -26. .612 1. .00 29. .64 0

ANISOU 1654 O LEU A 245 3268 4310 3683 649 - 967 1789 0

ATOM 1655 CB LEU A 245 4.706 10. .255 -26. .552 1. .00 18. .82 c

ANISOU 1655 CB LEU A 245 2837 1772 2540 -373 99 -255 c

ATOM 1656 CG LEU A 245 5.704 11. .412 -26. .645 1. .00 18. .48 c

ANISOU 1656 CG LEU A 245 2708 1778 2533 -313 95 -76 c

ATOM 1657 CD1 LEU A 245 6.295 11. .497 -28. .045 1. .00 21. .42 c

ANISOU 1657 CD1 LEU A 245 2553 2808 2774 -604 346 110 c

ATOM 1658 CD2 LEU A 245 5.068 12. ,738 -26. .246 1. .00 21. .83 c

ANISOU 1658 CD2 LEU A 245 3060 2130 3101 150 -34 -300 c

ATOM 1659 OXT LEU A 245 6.420 8. .529 -24. .888 1. .00 23. .80 0

ANISOU 1659 OXT LEU A 245 3565 2823 2651 -178 -1274 -194 0

TER 1660 LEU A 245

ATOM 1661 N PRO B 30 31.040 1. .604 -22. .143 1. .00 35. .89 N

ANISOU 1661 N PRO B 30 2393 4162 7080 -316 911 -80 N

ATOM 1662 CA PRO B 30 30.606 2. .903 -21. .653 1. .00 36. .11 C

ANISOU 1662 CA PRO B 30 2938 4752 6027 -211 580 -409 c

ATOM 1663 C PRO B 30 31.393 3. .345 -20. .428 1. .00 39. .07 c ANISOU 1663 C PRO B 30 4293 4254 6297 -308 -112 428 C

ATOM 1664 O PRO B 30 31.855 2. .513 -19. .645 1. .00 45. .06 O

ANISOU 1664 O PRO B 30 4894 5287 6940 -401 -1030 1032 O

ATOM 1665 CB PRO B 30 29.137 2. .663 -21. .296 1. .00 31. .74 C

ANISOU 1665 CB PRO B 30 2642 4168 5247 282 228 -92 C

ATOM 1666 CG PRO B 30 28.707 1. ,631 -22. .280 1. .00 32. .23 C

ANISOU 1666 CG PRO B 30 2491 4435 5321 56 95 -112 C

ATOM 1667 CD PRO B 30 29.900 0. .723 -22. .449 1. .00 33. .41 C

ANISOU 1667 CD PRO B 30 3010 3789 5894 140 -285 - 1013 C

ATOM 1668 N ASP B 31 31.555 4. .651 -20. .267 1. .00 31. .80 N

ANISOU 1668 N ASP B 31 2337 4361 5384 -365 -3 -157 N

ATOM 1669 CA ASP B 31 32.306 5. .144 -19. .137 1. .00 27. .80 C

ANISOU 1669 CA ASP B 31 1771 3848 4942 -358 239 520 C

ATOM 1670 C ASP B 31 31.617 6. .249 -18. .358 1. .00 23. .53 C

ANISOU 1670 C ASP B 31 1437 3810 3690 -497 -81 481 C

ATOM 1671 O ASP B 31 32.208 6. .803 -17. .450 1. .00 24. .92 O

ANISOU 1671 O ASP B 31 1160 4883 3423 -263 -670 956 O

ATOM 1672 CB ASP B 31 33.720 5. ,561 -19. .571 1. .00 26. .98 C

ANISOU 1672 CB ASP B 31 1541 4310 4400 -107 267 210 C

ATOM 1673 CG ASP B 31 33.726 6. .708 -20. .571 1. .00 28. .85 c

ANISOU 1673 CG ASP B 31 2756 4413 3790 -251 298 140 c

ATOM 1674 OD1 ASP B 31 32.647 7. .253 -20. .915 1. .00 26. .47 0

ANISOU 1674 OD1 ASP B 31 2019 4566 3470 -916 468 416 0

ATOM 1675 OD2 ASP B 31 34.836 7. .068 -21. .015 1. .00 39. .80 0

ANISOU 1675 OD2 ASP B 31 3187 5663 6270 -1009 748 33 0

ATOM 1676 N GLY B 32 30.364 6. .561 -18. .696 1. .00 20. .17 N

ANISOU 1676 N GLY B 32 1626 3130 2906 -258 -160 293 N

ATOM 1677 CA GLY B 32 29.648 7. .606 -17. .988 1. .00 18. .90 C

ANISOU 1677 CA GLY B 32 1802 2458 2921 -322 -423 349 C

ATOM 1678 C GLY B 32 29.944 9. .013 -18. .469 1. .00 21. .14 C

ANISOU 1678 C GLY B 32 1893 2733 3406 -541 -178 622 C

ATOM 1679 O GLY B 32 29.566 9. .988 -17. .816 1. .00 22. .83 O

ANISOU 1679 O GLY B 32 1808 3022 3842 -508 -203 482 0

ATOM 1680 N SER B 33 30.633 9. .128 -19. .600 1. .00 21. .66 N

ANISOU 1680 N SER B 33 1660 3095 3473 67 -243 1017 N

ATOM 1681 CA SER B 33 30.830 10. .421 -20. .244 1. .00 22. .59 C

ANISOU 1681 CA SER B 33 2135 3182 3265 -608 -301 884 C

ATOM 1682 C SER B 33 29.600 10. .710 -21. .105 1. .00 24. .03 C

ANISOU 1682 C SER B 33 2607 3067 3456 -621 -606 1164 C

ATOM 1683 O SER B 33 28.824 9. .796 -21. .405 1. .00 22. .83 O

ANISOU 1683 O SER B 33 2225 2832 3618 -604 407 1038 O

ATOM 1684 CB SER B 33 32.101 10. .417 -21. .095 1. .00 28. .49 C

ANISOU 1684 CB SER B 33 2785 4240 3798 -118 248 486 c

ATOM 1685 OG SER B 33 31.972 9. .535 -22. .199 1. .00 26. .26 0

ANISOU 1685 OG SER B 33 1783 5303 2889 -325 934 634 0

ATOM 1686 N ARG B 34 29.413 11. ,972 -21. .492 1. .00 26. .05 N

ANISOU 1686 N ARG B 34 2476 3238 4181 -541 -498 1479 N

ATOM 1687 CA ARG B 34 28.262 12. .354 -22. .307 1. .00 26. .09 C

ANISOU 1687 CA ARG B 34 3497 2766 3647 1 -771 1282 C

ATOM 1688 C ARG B 34 28.222 11. .612 -23. .639 1. .00 25. .36 C

ANISOU 1688 C ARG B 34 2839 3116 3678 -260 -249 961 C

ATOM 1689 O ARG B 34 27.157 11. .181 -24. .071 1. .00 26. .30 O

ANISOU 1689 O ARG B 34 2633 3663 3695 31 -342 686 O

ATOM 1690 CB ARG B 34 28.225 13. .863 -22. .535 1. .00 28. .01 c

ANISOU 1690 CB ARG B 34 3698 2570 4371 344 -967 925 c

ATOM 1691 CG ARG B 34 26.889 14. .386 -23. .031 1. .00 29. .09 c

ANISOU 1691 CG ARG B 34 3665 3376 4012 126 -1099 1274 c

ATOM 1692 CD ARG B 34 26.932 15. .903 -23. .100 1. .00 32. .17 c

ANISOU 1692 CD ARG B 34 4494 3339 4389 327 -2052 1161 c

ATOM 1693 NE ARG B 34 25.612 16. .465 -23. .362 1. .00 36. .23 N

ANISOU 1693 NE ARG B 34 4432 4545 4786 602 -1384 1092 N ATOM 1694 CZ ARG B 34 25.239 17..696 -23..029 1..00 35..14 C

ANISOU 1694 CZ ARG B 34 5218 4169 3965 73 -1745 974 C

ATOM 1695 NH1 ARG B 34 26.078 18. .515 -22. .405 1. .00 41. .50 N

ANISOU 1695 NH1 ARG B 34 7561 4466 3741 -1086 -1278 710 N

ATOM 1696 NH2 ARG B 34 24.017 18. .104 -23. .306 1. .00 41. .05 N

ANISOU 1696 NH2 ARG B 34 5925 4208 5463 1325 -1292 1232 N

ATOM 1697 N LYS B 35 29.382 11. ,457 -24. .274 1. .00 23. .93 N

ANISOU 1697 N LYS B 35 2285 3206 3598 -630 -649 1231 N

ATOM 1698 CA LYS B 35 29.500 10. .745 -25. .557 1. .00 27. .42 C

ANISOU 1698 CA LYS B 35 2699 3925 3794 -741 404 1106 C

ATOM 1699 C LYS B 35 29.384 9. .229 -25. .395 1. .00 25. .68 C

ANISOU 1699 C LYS B 35 3063 3717 2975 -230 -303 582 C

ATOM 1700 O LYS B 35 29.034 8. .530 -26. .336 1. .00 28. .17 O

ANISOU 1700 O LYS B 35 3615 4366 2720 -556 -470 786 O

ATOM 1701 CB LYS B 35 30.815 11. .123 -26. .283 1. .00 27. .00 C

ANISOU 1701 CB LYS B 35 2535 4049 3674 -1571 -62 945 C

ATOM 1702 N ASN B 36 29.671 8. .730 -24. .193 1. .00 23. .16 N

ANISOU 1702 N ASN B 36 2409 3057 3333 248 -23 848 N

ATOM 1703 CA ASN B 36 29.651 7. .305 -23. .913 1. .00 21. .62 C

ANISOU 1703 CA ASN B 36 2208 3128 2876 -85 452 745 C

ATOM 1704 C ASN B 36 28.901 6. .997 -22. .611 1. .00 19. .92 C

ANISOU 1704 C ASN B 36 2051 2791 2724 35 358 594 C

ATOM 1705 O ASN B 36 29.474 6. .436 -21. .672 1. .00 20. .20 O

ANISOU 1705 O ASN B 36 2231 3040 2403 -173 236 546 O

ATOM 1706 CB ASN B 36 31.099 6. ,795 -23. .841 1. .00 27. .60 C

ANISOU 1706 CB ASN B 36 2266 4493 3728 263 270 525 C

ATOM 1707 CG ASN B 36 31.212 5. .303 -24. .063 1. .00 35. .82 C

ANISOU 1707 CG ASN B 36 4105 5028 4477 518 417 -446 c

ATOM 1708 OD1 ASN B 36 30.220 4. .614 -24. .322 1. .00 40. .89 0

ANISOU 1708 OD1 ASN B 36 4283 6647 4606 -144 1352 -700 0

ATOM 1709 ND2 ASN B 36 32.431 4. .788 -23. .961 1. .00 44. .40 N

ANISOU 1709 ND2 ASN B 36 4436 7447 4985 1216 -311 - 1701 N

ATOM 1710 N PRO B 37 27.613 7. .360 -22. .544 1. .00 19. .03 N

ANISOU 1710 N PRO B 37 1880 3035 2314 -140 55 604 N

ATOM 1711 CA PRO B 37 26.865 7. .165 -21. .282 1. .00 17. .52 C

ANISOU 1711 CA PRO B 37 1208 3054 2393 -96 24 355 C

ATOM 1712 C PRO B 37 26.701 5. ,693 -20. .884 1. .00 15. .97 C

ANISOU 1712 C PRO B 37 1126 2920 2020 -14 -75 113 C

ATOM 1713 O PRO B 37 26.562 4. .826 -21. .758 1. .00 19. .69 O

ANISOU 1713 O PRO B 37 2427 2704 2347 173 -161 -47 O

ATOM 1714 CB PRO B 37 25.504 7. .804 -21. .588 1. .00 19. .88 C

ANISOU 1714 CB PRO B 37 1658 3161 2733 240 -328 307 C

ATOM 1715 CG PRO B 37 25.375 7. .715 -23. .058 1. .00 21. .12 C

ANISOU 1715 CG PRO B 37 1618 3700 2704 -67 18 50 C

ATOM 1716 CD PRO B 37 26.755 7. .895 -23. .617 1. .00 20. .80 C

ANISOU 1716 CD PRO B 37 1655 3578 2668 -61 -72 619 c

ATOM 1717 N ALA B 38 26.721 5. .410 -19. .578 1. .00 15. .54 N

ANISOU 1717 N ALA B 38 878 2792 2232 -198 -359 607 N

ATOM 1718 CA ALA B 38 26.404 4. .067 -19. .065 1. .00 16. .69 C

ANISOU 1718 CA ALA B 38 1476 2477 2389 99 -192 477 C

ATOM 1719 C ALA B 38 24.887 3. .935 -19. .005 1. .00 16. .31 C

ANISOU 1719 C ALA B 38 1576 2020 2601 -319 -509 234 C

ATOM 1720 O ALA B 38 24.174 4. .941 -19. .083 1. .00 17. .05 O

ANISOU 1720 O ALA B 38 1395 2577 2503 16 -225 215 O

ATOM 1721 CB ALA B 38 27.011 3. .861 -17. .671 1. .00 17. .74 c

ANISOU 1721 CB ALA B 38 1292 3029 2418 -129 -179 675 c

ATOM 1722 N ARG B 39 24.390 2. .712 -18. .864 1. .00 14. .01 N

ANISOU 1722 N ARG B 39 1091 2188 2045 -486 -300 229 N

ATOM 1723 CA ARG B 39 22.942 2. .518 -18. .742 1. .00 12. .03 C

ANISOU 1723 CA ARG B 39 1098 1407 2064 -415 -258 -46 C

ATOM 1724 C ARG B 39 22.405 3. .202 -17. .474 1. .00 14. .50 C ANISOU 1724 C ARG B 39 1566 2084 1858 -222 -287 -5 C

ATOM 1725 O ARG B 39 21.360 3. .868 -17. .509 1. .00 14. .63 O

ANISOU 1725 O ARG B 39 1531 1566 2461 -487 - 384 ^■183 O

ATOM 1726 CB ARG B 39 22.603 1. ,038 -18. .741 1. .00 11. .91 C

ANISOU 1726 CB ARG B 39 1279 1375 1871 -407 - 615 -93 C

ATOM 1727 CG ARG B 39 21.112 0. .765 -18. .673 1. .00 11. .51 C

ANISOU 1727 CG ARG B 39 1245 1220 1907 -145 - 161 -7 C

ATOM 1728 CD ARG B 39 20.869 -0. ,734 -18. .624 1. .00 12. .10 C

ANISOU 1728 CD ARG B 39 1556 1166 1873 0 - 124 69 C

ATOM 1729 NE ARG B 39 21.333 -1. ,357 -17. .373 1. .00 14. .02 N

ANISOU 1729 NE ARG B 39 1801 1641 1883 -259 -82 311 N

ATOM 1730 CZ ARG B 39 20.581 -1. ,475 -16. .275 1. .00 14. .18 C

ANISOU 1730 CZ ARG B 39 1710 1835 1842 -66 - 118 295 C

ATOM 1731 NH1 ARG B 39 19.341 -0. ,994 -16. .264 1. .00 15. .00 N

ANISOU 1731 NH1 ARG B 39 1750 1701 2246 -7 - 194 262 N

ATOM 1732 NH2 ARG B 39 21.060 -2. ,077 -15. .188 1. .00 13. .83 N

ANISOU 1732 NH2 ARG B 39 2109 1531 1614 52 58 195 N

ATOM 1733 N ASN B 40 23.117 3. .016 -16. .360 1. .00 13. .55 N

ANISOU 1733 N ASN B 40 1081 2267 1800 -63 -83 -16 N

ATOM 1734 CA ASN B 40 22.792 3. .655 -15. .083 1. .00 12. .52 C

ANISOU 1734 CA ASN B 40 1088 2021 1646 -359 -99 111 C

ATOM 1735 C ASN B 40 24.013 3. .518 -14. .188 1. .00 13. .09 C

ANISOU 1735 C ASN B 40 1320 2007 1644 -151 - 198 ^■103 C

ATOM 1736 O ASN B 40 25.045 2. .998 -14. .619 1. .00 14. .01 O

ANISOU 1736 O ASN B 40 1476 1830 2015 110 - 235 ^■220 O

ATOM 1737 CB ASN B 40 21.522 3. .029 -14. .444 1. .00 13. .06 C

ANISOU 1737 CB ASN B 40 1107 1779 2077 -337 28 109 C

ATOM 1738 CG ASN B 40 21.726 1. .609 -13. .941 1. .00 13. .37 C

ANISOU 1738 CG ASN B 40 1422 1747 1908 -528 146 74 C

ATOM 1739 OD1 ASN B 40 22.825 1. .055 -14. .022 1. .00 15. .11 O

ANISOU 1739 OD1 ASN B 40 1786 1708 2245 -156 - 234 525 O

ATOM 1740 ND2 ASN B 40 20.651 1. .005 -13. .404 1. .00 14. .86 N

ANISOU 1740 ND2 ASN B 40 1653 1961 2031 -703 294 93 N

ATOM 1741 N CYS B 41 23.894 3. .972 -12. .953 1. .00 13. .07 N

ANISOU 1741 N CYS B 41 1402 1990 1573 -171 - 428 ^■190 N

ATOM 1742 CA CYS B 41 25.050 4. .020 -12. .047 1. .00 13. .50 C

ANISOU 1742 CA CYS B 41 1464 1992 1672 -161 - 486 ^■119 C

ATOM 1743 C CYS B 41 25.442 2. ,646 -11. .546 1. .00 13. .86 C

ANISOU 1743 C CYS B 41 1552 1923 1788 -175 - 342 -67 C

ATOM 1744 O CYS B 41 26.616 2. .401 -11. .285 1. .00 13. .93 O

ANISOU 1744 O CYS B 41 1587 1709 1995 106 -70 -35 O

ATOM 1745 CB CYS B 41 24.782 4. .965 -10. .871 1. .00 13. .86 C

ANISOU 1745 CB CYS B 41 1324 1984 1958 134 -89 ^■133 C

ATOM 1746 SG CYS B 41 24.503 6. .668 -11. .378 1. .00 14. .84 S

ANISOU 1746 SG CYS B 41 1459 2020 2160 39 - 143 -71 S

ATOM 1747 N ARG B 42 24.465 1. .745 -11. .425 1. .00 13. .56 N

ANISOU 1747 N ARG B 42 1807 1542 1800 -102 -59 47 N

ATOM 1748 CA ARG B 42 24.749 0. .391 -10. .955 1. .00 12. .91 C

ANISOU 1748 CA ARG B 42 1713 1501 1690 -93 -14 -46 C

ATOM 1749 C ARG B 42 25.626 -0. ,362 -11. .957 1. .00 12. .60 C

ANISOU 1749 C ARG B 42 1478 1716 1590 198 - 150 117 C

ATOM 1750 O ARG B 42 26.548 -1. ,061 -11. .555 1. .00 12. .90 O

ANISOU 1750 O ARG B 42 1502 1854 1546 176 - 309 152 O

ATOM 1751 CB ARG B 42 23.465 -0. ,419 -10. .707 1. .00 12. .32 C

ANISOU 1751 CB ARG B 42 1615 1296 1770 57 - 112 395 C

ATOM 1752 CG ARG B 42 23.748 -1. ,790 -10. .065 1. .00 12. .20 c

ANISOU 1752 CG ARG B 42 1581 1532 1523 276 - 426 462 c

ATOM 1753 CD ARG B 42 24.118 -1. ,620 -8. .602 1. .00 14. .43 c

ANISOU 1753 CD ARG B 42 2051 2014 1415 88 - 142 409 c

ATOM 1754 NE ARG B 42 24.632 -2. ,820 -7. .923 1. .00 14. .38 N

ANISOU 1754 NE ARG B 42 1835 1657 1971 371 -54 56 N ATOM 1755 CZ ARG B 42 25.873 -3.,303 -8..049 1..00 16..38 C

ANISOU 1755 CZ ARG B 42 1900 1699 2624 294 67 191 C

ATOM 1756 NH1 ARG B 42 26.739 -2. ,736 -8. .888 1. .00 15. .66 N

ANISOU 1756 NH1 ARG B 42 1608 2402 1940 310 - 322 470 N

ATOM 1757 NH2 ARG B 42 26.256 -4. ,353 -7. .333 1. .00 17. .10 N

ANISOU 1757 NH2 ARG B 42 2103 1651 2741 -68 - 378 225 N

ATOM 1758 N ASP B 43 25.326 -0. ,222 -13. .253 1. .00 13. .39 N

ANISOU 1758 N ASP B 43 1553 2055 1478 -30 - 136 -161 N

ATOM 1759 CA ASP B 43 26.185 -0. ,812 -14. .291 1. .00 14. .52 C

ANISOU 1759 CA ASP B 43 1632 2041 1844 263 -54 -243 C

ATOM 1760 C ASP B 43 27.588 -0. ,205 -14. .268 1. .00 15. .62 C

ANISOU 1760 C ASP B 43 1836 2033 2065 63 - 235 -246 C

ATOM 1761 O ASP B 43 28.571 -0. ,918 -14. .437 1. .00 16. .07 O

ANISOU 1761 O ASP B 43 1695 2438 1972 107 382 112 O

ATOM 1762 CB ASP B 43 25.599 -0. ,610 -15. .689 1. .00 15. .53 C

ANISOU 1762 CB ASP B 43 1919 2179 1802 104 -93 -399 C

ATOM 1763 CG ASP B 43 24.464 -1. ,554 -15. .991 1. .00 16. .84 C

ANISOU 1763 CG ASP B 43 2086 2092 2221 168 - 335 -431 C

ATOM 1764 OD1 ASP B 43 23.892 -2. ,174 -15. .051 1. .00 17. .53 O

ANISOU 1764 OD1 ASP B 43 2043 2439 2177 97 - 318 -407 O

ATOM 1765 OD2 ASP B 43 24.144 -1. ,667 -17. .191 1. .00 18. .16 O

ANISOU 1765 OD2 ASP B 43 2444 2201 2253 -108 - 549 -260 O

ATOM 1766 N LEU B 44 27.667 1. .112 -14. .082 1. .00 15. .33 N

ANISOU 1766 N LEU B 44 1920 2061 1842 -65 - 166 -154 N

ATOM 1767 CA LEU B 44 28.958 1. ,789 -14. .007 1. .00 17. .86 C

ANISOU 1767 CA LEU B 44 2138 2152 2494 -256 58 69 C

ATOM 1768 C LEU B 44 29.803 1. .232 -12. .864 1. .00 17. .77 C

ANISOU 1768 C LEU B 44 1905 2502 2343 -144 164 -89 C

ATOM 1769 O LEU B 44 30.988 0. .937 -13. .040 1. .00 17. .45 O

ANISOU 1769 O LEU B 44 1920 2683 2028 -90 200 -403 O

ATOM 1770 CB LEU B 44 28.739 3. .283 -13. .859 1. .00 19. .28 C

ANISOU 1770 CB LEU B 44 2448 2177 2699 -240 426 -361 C

ATOM 1771 CG LEU B 44 29.809 4. .271 -14. .289 1. .00 20. .33 c

ANISOU 1771 CG LEU B 44 2374 2495 2854 -74 522 132 c

ATOM 1772 CD1 LEU B 44 30.194 4. .130 -15. .763 1. .00 19. .57 c

ANISOU 1772 CD1 LEU B 44 2316 2657 2461 -349 -70 -203 c

ATOM 1773 CD2 LEU B 44 29.268 5. .667 -14. .021 1. .00 24. .10 c

ANISOU 1773 CD2 LEU B 44 2898 2671 3587 99 820 -122 c

ATOM 1774 N LYS B 45 29.182 1. .046 -11. .706 1. .00 15. .70 N

ANISOU 1774 N LYS B 45 1794 2064 2108 -142 -48 -144 N

ATOM 1775 CA LYS B 45 29.863 0. .460 -10. .554 1. .00 16. .46 C

ANISOU 1775 CA LYS B 45 1948 2273 2033 -109 - 110 -308 C

ATOM 1776 C LYS B 45 30.304 -0. ,980 -10. .818 1. .00 16. .39 C

ANISOU 1776 C LYS B 45 1662 2191 2373 -242 - 244 -229 C

ATOM 1777 O LYS B 45 31.442 -1. ,366 -10. .502 1. .00 19. .37 O

ANISOU 1777 O LYS B 45 1499 2862 2998 -95 - 158 -602 0

ATOM 1778 CB LYS B 45 28.973 0. ,533 -9. .301 1. .00 15. .08 c

ANISOU 1778 CB LYS B 45 1583 2185 1959 -103 - 213 88 c

ATOM 1779 CG LYS B 45 29.594 -0. ,125 -8. .076 1. .00 18. .03 c

ANISOU 1779 CG LYS B 45 2477 2565 1809 -106 - 611 -59 c

ATOM 1780 CD LYS B 45 28.702 -0. ,055 -6. .848 1. .00 19. .59 c

ANISOU 1780 CD LYS B 45 2316 2762 2363 202 - 473 184 c

ATOM 1781 CE LYS B 45 29.421 -0. ,727 -5. .686 1. .00 23. .81 c

ANISOU 1781 CE LYS B 45 3849 3166 2030 958 134 724 c

ATOM 1782 NZ LYS B 45 28.477 -1. ,115 -4. .624 1. .00 30. .27 N

ANISOU 1782 NZ LYS B 45 2406 5000 4094 -700 - 634 1616 N

ATOM 1783 N PHE B 46 29.401 -1. ,771 -11. .396 1. .00 14. .87 N

ANISOU 1783 N PHE B 46 1544 1969 2134 -94 -30 -483 N

ATOM 1784 CA PHE B 46 29.666 -3. ,178 -11. .622 1. .00 15. .40 C

ANISOU 1784 CA PHE B 46 1200 2018 2630 196 129 -317 C

ATOM 1785 C PHE B 46 30.857 -3. ,360 -12. .572 1. .00 14. .78 C ANISOU 1785 C PHE B 46 1125 1897 2594 280 53 -346 C

ATOM 1786 O PHE B 46 31.742 -4. ,198 -12. .334 1. .00 18. .69 O

ANISOU 1786 O PHE B 46 1469 2589 3042 686 -461 -349 O

ATOM 1787 CB PHE B 46 28.426 -3. ,890 -12. .177 1. .00 16. .24 C

ANISOU 1787 CB PHE B 46 1583 1828 2758 22 -89 -86 C

ATOM 1788 CG PHE B 46 28.407 -5. ,359 -11. .881 1. .00 16. .66 C

ANISOU 1788 CG PHE B 46 1817 1976 2535 98 143 167 C

ATOM 1789 CD1 PHE B 46 29.180 -6. ,244 -12. .623 1. .00 16. .21 C

ANISOU 1789 CD1 PHE B 46 1559 2598 2001 -100 423 29 C

ATOM 1790 CD2 PHE B 46 27.629 -5. ,858 -10. .847 1. .00 16. .98 C

ANISOU 1790 CD2 PHE B 46 1785 2175 2490 337 262 249 C

ATOM 1791 CE1 PHE B 46 29.173 -7. ,597 -12. .344 1. .00 17. .07 C

ANISOU 1791 CE1 PHE B 46 1650 2829 2006 -136 234 283 C

ATOM 1792 CE2 PHE B 46 27.619 -7. ,210 -10. .555 1. .00 16. .34 C

ANISOU 1792 CE2 PHE B 46 1948 2043 2217 -181 49 236 C

ATOM 1793 CZ PHE B 46 28.401 -8. ,080 -11. .306 1. .00 15. .89 C

ANISOU 1793 CZ PHE B 46 2058 2269 1708 -167 -7 507 C

ATOM 1794 N CYS B 47 30.873 -2. ,556 -13. .632 1. .00 15. .72 N

ANISOU 1794 N CYS B 47 1225 2325 2423 -264 -126 -386 N

ATOM 1795 CA CYS B 47 31.886 -2. ,639 -14. .675 1. .00 18. .29 C

ANISOU 1795 CA CYS B 47 1474 2638 2836 0 146 -490 C

ATOM 1796 C CYS B 47 33.177 -1. ,859 -14. .344 1. .00 21. .71 C

ANISOU 1796 C CYS B 47 1951 3019 3277 -200 -215 - 1099 C

ATOM 1797 O CYS B 47 34.253 -2. ,187 -14. .859 1. .00 24. .16 O

ANISOU 1797 O CYS B 47 1985 3279 3913 -235 19 - 1182 O

ATOM 1798 CB CYS B 47 31.274 -2. ,202 -16. .018 1. .00 19. .08 C

ANISOU 1798 CB CYS B 47 1736 2643 2869 114 105 -288 C

ATOM 1799 SG CYS B 47 30.808 -3. ,594 -17. .096 1. .00 22. .76 s

ANISOU 1799 SG CYS B 47 1955 3609 3083 -160 -100 -626 s

ATOM 1800 N HIS B 48 33.071 -0. ,855 -13. .472 1. .00 16. .57 N

ANISOU 1800 N HIS B 48 1656 2348 2291 -21 -250 -299 N

ATOM 1801 CA HIS B 48 34.217 -0. ,004 -13. .097 1. .00 21. .38 C

ANISOU 1801 CA HIS B 48 1850 3300 2972 -500 -210 -366 C

ATOM 1802 C HIS B 48 34.287 0. .224 -11. .611 1. .00 19. .59 C

ANISOU 1802 C HIS B 48 1574 2781 3086 -325 -677 -548 C

ATOM 1803 O HIS B 48 33.939 1. .310 -11. .136 1. .00 19. .28 O

ANISOU 1803 O HIS B 48 1817 2690 2818 -232 -347 -325 O

ATOM 1804 CB HIS B 48 34.108 1. .352 -13. .771 1. .00 19. .54 C

ANISOU 1804 CB HIS B 48 1514 3562 2346 -778 -36 -152 c

ATOM 1805 CG HIS B 48 34.127 1. .290 -15. .266 1. .00 23. .91 c

ANISOU 1805 CG HIS B 48 2339 4386 2359 75 274 101 c

ATOM 1806 ND1 HIS B 48 33.006 1. ,225 -16. .001 1. .00 30. .88 N

ANISOU 1806 ND1 HIS B 48 3340 5327 3066 -251 -622 383 N

ATOM 1807 CD2 HIS B 48 35.186 1. .271 -16. .162 1. .00 31. .64 C

ANISOU 1807 CD2 HIS B 48 2880 6440 2700 -709 799 89 C

ATOM 1808 CE1 HIS B 48 33.329 1. .180 -17. .307 1. .00 33. .71 C

ANISOU 1808 CE1 HIS B 48 3940 6425 2443 10 -1441 619 C

ATOM 1809 NE2 HIS B 48 34.660 1. .211 -17. .404 1. .00 38. .62 N

ANISOU 1809 NE2 HIS B 48 4291 7241 3141 -121 -5 517 N

ATOM 1810 N PRO B 49 34.740 -0. ,784 -10. .844 1. .00 21. .87 N

ANISOU 1810 N PRO B 49 1930 3173 3206 40 -716 -529 N

ATOM 1811 CA PRO B 49 34.796 -0. ,599 -9. .381 1. .00 24. .17 C

ANISOU 1811 CA PRO B 49 2797 3138 3248 251 -886 -602 C

ATOM 1812 C PRO B 49 35.687 0. ,558 -8. .890 1. .00 20. .50 C

ANISOU 1812 C PRO B 49 2576 2680 2530 547 -618 -537 C

ATOM 1813 O PRO B 49 35.561 0. .955 -7. .742 1. .00 27. .98 O

ANISOU 1813 O PRO B 49 4108 4116 2408 687 -1302 -903 O

ATOM 1814 CB PRO B 49 35.321 -1. ,946 -8. .858 1. .00 26. .35 C

ANISOU 1814 CB PRO B 49 3427 3380 3203 433 -894 -302 C

ATOM 1815 CG PRO B 49 35.826 -2. ,688 -10. .044 1. .00 28. .67 C

ANISOU 1815 CG PRO B 49 2543 4566 3782 1353 -528 -310 C ATOM 1816 CD PRO B 49 35.162 -2.,134 -11..264 1..00 22..84 C

ANISOU 1816 CD PRO B 49 2027 3178 3471 384 -526 -422 C

ATOM 1817 N GLU B 50 36.553 1. .096 -9. .749 1. .00 25. .03 N

ANISOU 1817 N GLU B 50 2014 3376 4120 -396 -607 -147 N

ATOM 1818 CA GLU B 50 37.471 2. .192 -9. .372 1. .00 26. .99 C

ANISOU 1818 CA GLU B 50 3511 2907 3835 -301 -596 -819 C

ATOM 1819 C GLU B 50 36.816 3. .584 -9. .429 1. .00 25. .83 C

ANISOU 1819 C GLU B 50 2406 3673 3732 166 -1738 -843 C

ATOM 1820 O GLU B 50 37.351 4. .555 -8. .878 1. .00 25. .33 O

ANISOU 1820 O GLU B 50 1878 3476 4268 -143 -1158 -691 O

ATOM 1821 CB GLU B 50 38.731 2. ,164 -10. .254 1. .00 34. .97 C

ANISOU 1821 CB GLU B 50 3417 4469 5400 -472 -126 -614 C

ATOM 1822 CG GLU B 50 38.585 2. .807 -11. .642 1. .00 35. .55 C

ANISOU 1822 CG GLU B 50 3010 5493 5004 144 253 -443 c

ATOM 1823 CD GLU B 50 37.830 1. .959 -12. .674 1. .00 34. .56 c

ANISOU 1823 CD GLU B 50 2912 4949 5268 -276 553 -106 c

ATOM 1824 OE1 GLU B 50 37.355 0. .838 -12. .358 1. .00 28. .98 0

ANISOU 1824 OE1 GLU B 50 2000 4282 4728 39 -102 -543 0

ATOM 1825 OE2 GLU B 50 37.713 2. .425 -13. .834 1. .00 39. .24 0

ANISOU 1825 OE2 GLU B 50 3244 6409 5252 -962 1400 443 0

ATOM 1826 N LEU B 51 35.675 3. .686 -10. .104 1. .00 19. .05 N

ANISOU 1826 N LEU B 51 1316 3085 2836 314 -569 -527 N

ATOM 1827 CA LEU B 51 34.984 4. .973 -10. .212 1. .00 19. .11 C

ANISOU 1827 CA LEU B 51 2162 2741 2356 94 -872 -608 C

ATOM 1828 C LEU B 51 34.392 5. .459 -8. .883 1. .00 18. .85 C

ANISOU 1828 C LEU B 51 1997 2603 2560 -12 -714 -627 C

ATOM 1829 O LEU B 51 33.836 4. .677 -8. .107 1. .00 16. .90 0

ANISOU 1829 O LEU B 51 1746 2156 2516 365 -385 -687 0

ATOM 1830 CB LEU B 51 33.925 4. .927 -11. .317 1. .00 18. .12 c

ANISOU 1830 CB LEU B 51 1884 2866 2134 -303 -638 -402 c

ATOM 1831 CG LEU B 51 34.519 4. .880 -12. .733 1. .00 21. .35 c

ANISOU 1831 CG LEU B 51 2389 3570 2154 -729 -512 -667 c

ATOM 1832 CD1 LEU B 51 33.409 4. ,779 -13. .762 1. .00 23. .42 c

ANISOU 1832 CD1 LEU B 51 2665 3831 2399 -139 -890 -103 c

ATOM 1833 CD2 LEU B 51 35.403 6. .083 -13. .031 1. .00 23. .92 c

ANISOU 1833 CD2 LEU B 51 1816 4451 2821 -728 162 -150 c

ATOM 1834 N LYS B 52 34.541 6. .756 -8. .629 1. .00 18. .78 N

ANISOU 1834 N LYS B 52 1783 2721 2631 125 -1033 - 1021 N

ATOM 1835 CA LYS B 52 34.093 7. .358 -7. .379 1. .00 18. .69 C

ANISOU 1835 CA LYS B 52 1289 3070 2743 -551 -879 - 1146 C

ATOM 1836 C LYS B 52 32.713 7. .987 -7. .540 1. .00 18. .89 C

ANISOU 1836 C LYS B 52 1700 2784 2691 -180 -731 -655 C

ATOM 1837 O LYS B 52 32.256 8. .246 -8. .657 1. .00 18. .78 0

ANISOU 1837 O LYS B 52 1066 3468 2601 -215 -655 -485 0

ATOM 1838 CB LYS B 52 35.090 8. .430 -6. .931 1. .00 19. .11 c

ANISOU 1838 CB LYS B 52 1173 3032 3055 -587 -1342 -565 c

ATOM 1839 CG LYS B 52 36.462 7. .913 -6. .496 1. .00 24. .87 c

ANISOU 1839 CG LYS B 52 1457 4141 3852 -79 -1872 - 1510 c

ATOM 1840 CD LYS B 52 37.349 9. .099 -6. .148 1. .00 34. .03 c

ANISOU 1840 CD LYS B 52 2209 4851 5869 -1021 -1974 - 1079 c

ATOM 1841 CE LYS B 52 38.823 8. .739 -6. .233 1. .00 36. .63 c

ANISOU 1841 CE LYS B 52 2166 5842 5907 -774 -2090 -875 c

ATOM 1842 NZ LYS B 52 39.249 7. .990 -5. .030 1. .00 42. .69 N

ANISOU 1842 NZ LYS B 52 2659 6472 7086 1223 -1163 192 N

ATOM 1843 N SER B 53 32.051 8. .240 -6. .415 1. .00 19. .60 N

ANISOU 1843 N SER B 53 1352 3040 3054 -222 -489 -449 N

ATOM 1844 CA SER B 53 30.748 8. .915 -6. .431 1. .00 17. .67 C

ANISOU 1844 CA SER B 53 1508 2334 2871 -210 -940 -530 C

ATOM 1845 C SER B 53 30.879 10. .285 -7. .053 1. .00 17. .69 C

ANISOU 1845 C SER B 53 1826 2610 2282 -114 -753 -422 C

ATOM 1846 O SER B 53 31.898 10. .938 -6. .890 1. .00 20. .82 O ANISOU 1846 O SER B 53 2158 2924 2826 -461 -769 -808 O

ATOM 1847 CB SER B 53 30.191 9. .042 -5. .024 1. .00 18. .11 C

ANISOU 1847 CB SER B 53 1717 2314 2850 -Ill - 815 -4 C

ATOM 1848 OG SER B 53 29.993 7. .765 -4. .471 1. .00 16. .84 O

ANISOU 1848 OG SER B 53 1722 2334 2341 -37 - 321 -51 O

ATOM 1849 N GLY B 54 29.841 10. ,720 -7. .762 1. .00 18. .78 N

ANISOU 1849 N GLY B 54 1902 2757 2474 83 - 664 -163 N

ATOM 1850 CA GLY B 54 29.880 12. .005 -8. .454 1. .00 20. .79 C

ANISOU 1850 CA GLY B 54 2190 2636 3072 201 - 496 -86 C

ATOM 1851 C GLY B 54 28.928 11. .997 -9. .627 1. .00 18. .65 C

ANISOU 1851 C GLY B 54 2437 2263 2385 -156 - 126 66 C

ATOM 1852 O GLY B 54 28.198 11. .016 -9. .841 1. .00 17. .21 O

ANISOU 1852 O GLY B 54 1613 2355 2567 -61 11 4 O

ATOM 1853 N GLU B 55 28.943 13. .090 -10. .393 1. .00 19. .20 N

ANISOU 1853 N GLU B 55 2593 2392 2307 -262 -76 169 N

ATOM 1854 CA GLU B 55 28.072 13. .218 -11. .552 1. .00 19. .14 C

ANISOU 1854 CA GLU B 55 2287 2602 2384 159 - 107 -71 C

ATOM 1855 C GLU B 55 28.602 12. .429 -12. .749 1. .00 17. .09 C

ANISOU 1855 C GLU B 55 1995 2133 2363 -242 - 422 -184 C

ATOM 1856 O GLU B 55 29.800 12. .449 -13. .033 1. .00 20. .82 O

ANISOU 1856 O GLU B 55 1983 3035 2890 -525 - 403 -109 O

ATOM 1857 CB GLU B 55 27.959 14. .672 -11. .955 1. .00 22. .95 C

ANISOU 1857 CB GLU B 55 3264 2315 3138 295 - 484 -415 C

ATOM 1858 CG GLU B 55 27.203 15. .538 -10. .968 1. .00 30. .99 c

ANISOU 1858 CG GLU B 55 4580 2996 4199 980 -91 -644 c

ATOM 1859 CD GLU B 55 26.974 16. .928 -11. .519 1. .00 41. .17 c

ANISOU 1859 CD GLU B 55 5170 3324 7149 1216 21 233 c

ATOM 1860 OE1 GLU B 55 27.970 17. ,605 -11. .862 1. .00 48. .88 0

ANISOU 1860 OE1 GLU B 55 6918 3657 7996 152 274 582 0

ATOM 1861 OE2 GLU B 55 25.801 17. .334 -11. .627 1. .00 49. .28 0

ANISOU 1861 OE2 GLU B 55 5554 5069 8101 2420 411 1247 0

ATOM 1862 N TYR B 56 27.691 11. .761 -13. .452 1. .00 16. .47 N

ANISOU 1862 N TYR B 56 1247 2348 2660 -128 - 384 -63 N

ATOM 1863 CA TYR B 56 27.986 11. .037 -14. .680 1. .00 13. .20 C

ANISOU 1863 CA TYR B 56 1079 1556 2379 -615 - 590 209 C

ATOM 1864 C TYR B 56 26.762 11. .130 -15. .574 1. .00 15. .34 C

ANISOU 1864 C TYR B 56 1437 1921 2468 -188 - 799 206 C

ATOM 1865 O TYR B 56 25.678 11. .521 -15. .124 1. .00 18. .40 0

ANISOU 1865 O TYR B 56 1279 2858 2854 -783 - 262 199 0

ATOM 1866 CB TYR B 56 28.233 9. .536 -14. .401 1. .00 14. .29 c

ANISOU 1866 CB TYR B 56 1326 1674 2429 -217 - 620 97 c

ATOM 1867 CG TYR B 56 29.463 9. .203 -13. .585 1. .00 13. .89 c

ANISOU 1867 CG TYR B 56 865 2120 2293 -266 - 254 205 c

ATOM 1868 CD1 TYR B 56 29.411 9. .178 -12. .191 1. .00 16. .82 c

ANISOU 1868 CD1 TYR B 56 1603 2473 2313 -201 - 834 100 c

ATOM 1869 CD2 TYR B 56 30.671 8. ,876 -14. .203 1. .00 16. .94 c

ANISOU 1869 CD2 TYR B 56 1238 2660 2535 22 -79 -46 c

ATOM 1870 CE1 TYR B 56 30.533 8. .862 -11. .429 1. .00 16. .74 c

ANISOU 1870 CE1 TYR B 56 1200 2675 2486 -465 - 703 213 c

ATOM 1871 CE2 TYR B 56 31.790 8. .552 -13. .444 1. .00 17. .13 c

ANISOU 1871 CE2 TYR B 56 1359 2694 2455 268 82 335 c

ATOM 1872 CZ TYR B 56 31.718 8. .551 -12. .063 1. .00 18. .69 c

ANISOU 1872 CZ TYR B 56 1793 2901 2404 -130 - 406 -19 c

ATOM 1873 OH TYR B 56 32.840 8. .224 -11. .315 1. .00 20. .64 0

ANISOU 1873 OH TYR B 56 1756 2757 3328 -263 - 556 331 0

ATOM 1874 N TRP B 57 26.969 10. .763 -16. .837 1. .00 16. .68 N

ANISOU 1874 N TRP B 57 1711 2312 2314 -629 - 601 488 N

ATOM 1875 CA TRP B 57 25.930 10. ,650 -17. .848 1. .00 16. .91 c

ANISOU 1875 CA TRP B 57 1755 2156 2513 -400 - 712 303 c

ATOM 1876 C TRP B 57 25.514 9. .225 -17. .986 1. .00 17. .76 c

ANISOU 1876 C TRP B 57 1816 2107 2826 -327 - 385 228 c ATOM 1877 O TRP B 57 26.357 8..329 -18..218 1..00 16..48 O

ANISOU 1877 O TRP B 57 1173 2450 2636 -341 -573 104 O

ATOM 1878 CB TRP B 57 26.444 11. .167 -19. .182 1. .00 19. .05 C

ANISOU 1878 CB TRP B 57 1921 2528 2787 -501 -575 688 C

ATOM 1879 CG TRP B 57 26.652 12. .656 -19. .154 1. .00 20. .37 C

ANISOU 1879 CG TRP B 57 2367 2442 2931 -227 -718 456 C

ATOM 1880 CD1 TRP B 57 27.781 13. .352 -18. .708 1. .00 24. .42 C

ANISOU 1880 CD1 TRP B 57 2835 2980 3461 -410 -1298 500 C

ATOM 1881 CD2 TRP B 57 25.691 13. .691 -19. .547 1. .00 21. .22 C

ANISOU 1881 CD2 TRP B 57 2388 2274 3401 -409 -867 717 C

ATOM 1882 NE1 TRP B 57 27.590 14. .705 -18. .808 1. .00 25. .36 N

ANISOU 1882 NE1 TRP B 57 2552 3123 3960 -208 -1113 832 N

ATOM 1883 CE2 TRP B 57 26.356 14. .979 -19. .306 1. .00 22. .14 C

ANISOU 1883 CE2 TRP B 57 2172 2829 3408 -787 -1086 439 C

ATOM 1884 CE3 TRP B 57 24.398 13. .684 -20. .074 1. .00 19. .17 C

ANISOU 1884 CE3 TRP B 57 2423 2063 2798 -551 -832 869 C

ATOM 1885 CZ2 TRP B 57 25.733 16. .193 -19. .581 1. .00 24. .53 C

ANISOU 1885 CZ2 TRP B 57 2852 2786 3683 -831 -1244 807 C

ATOM 1886 CZ3 TRP B 57 23.780 14. .918 -20. .341 1. .00 21. .62 C

ANISOU 1886 CZ3 TRP B 57 2993 2037 3185 -522 -1042 891 C

ATOM 1887 CH2 TRP B 57 24.434 16. .140 -20. .100 1. .00 23. .12 c

ANISOU 1887 CH2 TRP B 57 2432 2633 3716 -892 -726 576 c

ATOM 1888 N VAL B 58 24.211 9. .006 -17. .839 1. .00 15. .67 N

ANISOU 1888 N VAL B 58 1728 2085 2138 -177 -347 -3 N

ATOM 1889 CA VAL B 58 23.619 7. ,688 -18. .016 1. .00 12. .92 C

ANISOU 1889 CA VAL B 58 1358 2036 1514 -112 -431 44 C

ATOM 1890 C VAL B 58 22.442 7. .761 -18. .995 1. .00 13. .62 C

ANISOU 1890 C VAL B 58 1295 2219 1660 -211 -432 -4 C

ATOM 1891 O VAL B 58 21.899 8. .844 -19. .295 1. .00 15. .92 O

ANISOU 1891 O VAL B 58 1615 2145 2287 -347 -217 230 O

ATOM 1892 CB VAL B 58 23.179 7. .043 -16. .669 1. .00 11. .44 C

ANISOU 1892 CB VAL B 58 888 2090 1368 -22 -618 18 c

ATOM 1893 CGI VAL B 58 24.378 6. .895 -15. .710 1. .00 13. .80 c

ANISOU 1893 CGI VAL B 58 1248 2355 1638 128 -913 153 c

ATOM 1894 CG2 VAL B 58 22.068 7. .860 -16. .023 1. .00 15. .95 c

ANISOU 1894 CG2 VAL B 58 1111 2361 2586 -117 -208 -290 c

ATOM 1895 N ASP B 59 22.067 6. .600 -19. .515 1. .00 13. .56 N

ANISOU 1895 N ASP B 59 1593 2398 1161 -463 -423 -1 N

ATOM 1896 CA ASP B 59 21.047 6. .529 -20. .561 1. .00 13. .89 C

ANISOU 1896 CA ASP B 59 1519 2361 1394 -Ill -558 238 C

ATOM 1897 C ASP B 59 20.171 5. .294 -20. .353 1. .00 13. .93 C

ANISOU 1897 C ASP B 59 1747 2289 1255 -130 -310 182 C

ATOM 1898 O ASP B 59 20.321 4. .306 -21. .080 1. .00 14. .56 O

ANISOU 1898 O ASP B 59 1710 1939 1881 -160 -342 139 0

ATOM 1899 CB ASP B 59 21.748 6. .467 -21. .921 1. .00 15. .44 c

ANISOU 1899 CB ASP B 59 1751 2587 1527 -232 -361 349 c

ATOM 1900 CG ASP B 59 20.792 6. ,653 -23. .092 1. .00 16. .07 c

ANISOU 1900 CG ASP B 59 1719 2396 1991 97 -494 796 c

ATOM 1901 OD1 ASP B 59 19.814 7. .385 -22. .928 1. .00 16. .29 0

ANISOU 1901 OD1 ASP B 59 1699 2168 2320 -179 -66 454 0

ATOM 1902 OD2 ASP B 59 21.017 6. .083 -24. .192 1. .00 17. .44 0

ANISOU 1902 OD2 ASP B 59 1727 2397 2502 80 -422 637 0

ATOM 1903 N PRO B 60 19.255 5. .337 -19. .351 1. .00 13. .09 N

ANISOU 1903 N PRO B 60 1165 1841 1965 16 -195 -59 N

ATOM 1904 CA PRO B 60 18.473 4. .145 -18. .997 1. .00 13. .10 C

ANISOU 1904 CA PRO B 60 936 2191 1849 -117 -159 27 C

ATOM 1905 C PRO B 60 17.672 3. .554 -20. .169 1. .00 14. .08 C

ANISOU 1905 C PRO B 60 1259 2035 2055 -178 -335 30 C

ATOM 1906 O PRO B 60 17.515 2. ,331 -20. .245 1. .00 14. .40 0

ANISOU 1906 O PRO B 60 1301 1932 2237 62 -303 28 0

ATOM 1907 CB PRO B 60 17.535 4. .650 -17. .885 1. .00 14. .08 c ANISOU 1907 CB PRO B 60 1543 2252 1553 -189 - 164 -222 C

ATOM 1908 CG PRO B 60 18.275 5. .799 -17. .275 1. .00 13. .78 C

ANISOU 1908 CG PRO B 60 1563 2001 1669 -288 -86 107 C

ATOM 1909 CD PRO B 60 18.976 6. .461 -18. .440 1. .00 13. .80 C

ANISOU 1909 CD PRO B 60 1657 2247 1340 -191 23 -75 C

ATOM 1910 N ASN B 61 17.204 4. .401 -21. .085 1. .00 14. .97 N

ANISOU 1910 N ASN B 61 1208 2521 1959 -242 - 225 291 N

ATOM 1911 CA ASN B 61 16.388 3. .896 -22. .195 1. .00 14. .17 C

ANISOU 1911 CA ASN B 61 1333 2170 1879 36 - 306 331 C

ATOM 1912 C ASN B 61 17.230 3. .348 -23. .348 1. .00 16. .14 C

ANISOU 1912 C ASN B 61 1981 1945 2206 137 - 194 12 C

ATOM 1913 O ASN B 61 16.681 2. .812 -24. .304 1. .00 15. .56 O

ANISOU 1913 O ASN B 61 1802 1990 2118 -196 - 115 313 O

ATOM 1914 CB ASN B 61 15.343 4. .935 -22. .678 1. .00 13. .33 C

ANISOU 1914 CB ASN B 61 1390 1916 1758 -28 - 362 234 C

ATOM 1915 CG ASN B 61 15.961 6. ,167 -23. .307 1. .00 14. .07 C

ANISOU 1915 CG ASN B 61 1658 2025 1661 -93 - 392 312 c

ATOM 1916 OD1 ASN B 61 17.180 6. .239 -23. .537 1. .00 15. .45 0

ANISOU 1916 OD1 ASN B 61 1630 2191 2049 -27 - 514 307 0

ATOM 1917 ND2 ASN B 61 15.116 7. .146 -23. .621 1. .00 14. .83 N

ANISOU 1917 ND2 ASN B 61 1402 2146 2086 -89 - 313 205 N

ATOM 1918 N GLN B 62 18.558 3. .493 -23. .233 1. .00 15. .60 N

ANISOU 1918 N GLN B 62 1918 1710 2296 -56 72 149 N

ATOM 1919 CA GLN B 62 19.513 3. .034 -24. .258 1. .00 17. .07 C

ANISOU 1919 CA GLN B 62 2124 2287 2073 -33 3 77 C

ATOM 1920 C GLN B 62 19.151 3. .586 -25. .646 1. .00 17. .55 C

ANISOU 1920 C GLN B 62 2017 2537 2114 -207 0 217 C

ATOM 1921 O GLN B 62 18.729 4. .736 -25. .747 1. .00 17. .75 O

ANISOU 1921 O GLN B 62 2437 2618 1686 -24 - 166 -30 O

ATOM 1922 CB GLN B 62 19.618 1. .499 -24. .233 1. .00 17. .90 C

ANISOU 1922 CB GLN B 62 2508 2350 1942 427 - 191 10 C

ATOM 1923 CG GLN B 62 20.143 0. .971 -22. .913 1. .00 19. .90 C

ANISOU 1923 CG GLN B 62 2436 2673 2452 528 - 316 394 C

ATOM 1924 CD GLN B 62 21.615 1. .270 -22. .753 1. .00 19. .67 C

ANISOU 1924 CD GLN B 62 2190 2862 2422 888 184 138 c

ATOM 1925 OE1 GLN B 62 22.003 2. .241 -22. .093 1. .00 23. .85 0

ANISOU 1925 OE1 GLN B 62 2572 3698 2790 480 - 212 197 0

ATOM 1926 NE2 GLN B 62 22.442 0. .459 -23. .379 1. .00 18. .31 N

ANISOU 1926 NE2 GLN B 62 2178 2344 2432 497 89 -254 N

ATOM 1927 N GLY B 63 19.293 2. .793 -26. .713 1. .00 19. .98 N

ANISOU 1927 N GLY B 63 2780 2817 1994 -26 -12 336 N

ATOM 1928 CA GLY B 63 18.924 3. .285 -28. .049 1. .00 20. .07 C

ANISOU 1928 CA GLY B 63 2656 2911 2057 247 12 424 C

ATOM 1929 C GLY B 63 19.754 4. ,514 -28. .412 1. .00 19. .89 C

ANISOU 1929 C GLY B 63 2405 3180 1970 308 -50 1079 C

ATOM 1930 O GLY B 63 20.979 4. .495 -28. .278 1. .00 22. .10 O

ANISOU 1930 O GLY B 63 2325 3207 2863 899 230 752 O

ATOM 1931 N CYS B 64 19.095 5. .589 -28. .841 1. .00 19. .16 N

ANISOU 1931 N CYS B 64 3027 2161 2089 -71 103 774 N

ATOM 1932 CA CYS B 64 19.772 6. .853 -29. .181 1. .00 19. .57 C

ANISOU 1932 CA CYS B 64 2259 2522 2654 -127 -28 966 C

ATOM 1933 C CYS B 64 20.548 7. .391 -27. .970 1. .00 20. .91 C

ANISOU 1933 C CYS B 64 2143 3217 2583 -246 153 830 C

ATOM 1934 O CYS B 64 19.985 7. .545 -26. .890 1. .00 19. .57 O

ANISOU 1934 O CYS B 64 1931 3242 2260 -386 - 116 791 O

ATOM 1935 CB CYS B 64 18.723 7. .877 -29. .641 1. .00 21. .09 C

ANISOU 1935 CB CYS B 64 2607 3154 2251 -92 - 481 1448 C

ATOM 1936 SG CYS B 64 19.352 9. .530 -30. .011 1. .00 24. .10 s

ANISOU 1936 SG CYS B 64 2458 3505 3193 -474 -57 1074 s

ATOM 1937 N LYS B 65 21.839 7. .663 -28. .143 1. .00 20. .19 N

ANISOU 1937 N LYS B 65 1791 3125 2753 242 - 167 713 N ATOM 1938 CA LYS B 65 22.668 8..178 -27..044 1..00 20..77 C

ANISOU 1938 CA LYS B 65 2131 3124 2636 -356 217 642 C

ATOM 1939 C LYS B 65 22.382 9. .633 -26. .662 1. .00 20. .25 C

ANISOU 1939 C LYS B 65 1901 3233 2559 -294 223 650 C

ATOM 1940 O LYS B 65 22.724 10. .060 -25. .551 1. .00 20. .74 O

ANISOU 1940 O LYS B 65 1660 3421 2798 -225 -79 932 O

ATOM 1941 CB LYS B 65 24.150 8. .037 -27. .403 1. .00 21. .37 C

ANISOU 1941 CB LYS B 65 2258 2741 3119 280 3 -47 C

ATOM 1942 CG LYS B 65 24.613 6. .595 -27. .512 1. .00 22. .56 C

ANISOU 1942 CG LYS B 65 2623 2601 3348 71 66 67 C

ATOM 1943 CD LYS B 65 26.089 6. ,523 -27. .889 1. .00 25. .64 C

ANISOU 1943 CD LYS B 65 2813 3025 3905 256 205 -210 C

ATOM 1944 CE LYS B 65 26.535 5. .077 -28. .009 1. .00 25. .85 C

ANISOU 1944 CE LYS B 65 2941 3029 3851 439 12 203 C

ATOM 1945 NZ LYS B 65 25.825 4. .193 -27. .035 1. .00 31. .88 N

ANISOU 1945 NZ LYS B 65 3077 4474 4562 -138 254 260 N

ATOM 1946 N LEU B 66 21.774 10. .396 -27. .570 1. .00 22. .03 N

ANISOU 1946 N LEU B 66 2183 3374 2813 -35 276 746 N

ATOM 1947 CA LEU B 66 21.659 11. .850 -27. .407 1. .00 22. .21 C

ANISOU 1947 CA LEU B 66 2789 3327 2320 -500 -272 463 C

ATOM 1948 C LEU B 66 20.722 12. .340 -26. .297 1. .00 21. .56 C

ANISOU 1948 C LEU B 66 2410 3155 2627 -242 -436 426 C

ATOM 1949 O LEU B 66 20.786 13. .509 -25. .913 1. .00 23. .01 O

ANISOU 1949 O LEU B 66 2988 2714 3039 -423 -287 769 O

ATOM 1950 CB LEU B 66 21.291 12. .531 -28. .736 1. .00 21. .80 C

ANISOU 1950 CB LEU B 66 2827 3010 2444 -490 -499 436 C

ATOM 1951 CG LEU B 66 22.331 12. .429 -29. .858 1. .00 26. .68 C

ANISOU 1951 CG LEU B 66 3714 4450 1971 -1630 -164 736 C

ATOM 1952 CD1 LEU B 66 21.866 13. .209 -31. .079 1. .00 28. .12 C

ANISOU 1952 CD1 LEU B 66 4371 3780 2530 -887 39 806 C

ATOM 1953 CD2 LEU B 66 23.701 12. .917 -29. .391 1. .00 27. .89 C

ANISOU 1953 CD2 LEU B 66 2708 4253 3635 -822 446 407 C

ATOM 1954 N ASP B 67 19.860 11. ,472 -25. .781 1. .00 20. .56 N

ANISOU 1954 N ASP B 67 2059 2840 2911 -238 -1079 645 N

ATOM 1955 CA ASP B 67 18.947 11. .884 -24. .710 1. .00 20. .25 C

ANISOU 1955 CA ASP B 67 1678 2722 3294 -113 -1042 257 C

ATOM 1956 C ASP B 67 19.421 11. .409 -23. .350 1. .00 19. .43 C

ANISOU 1956 C ASP B 67 1835 2440 3105 -214 -461 413 C

ATOM 1957 O ASP B 67 18.628 11. .274 -22. .419 1. .00 19. .25 O

ANISOU 1957 O ASP B 67 1330 2726 3256 38 -561 198 O

ATOM 1958 CB ASP B 67 17.503 11. .427 -24. .988 1. .00 19. .98 C

ANISOU 1958 CB ASP B 67 1479 2490 3623 229 -1012 233 C

ATOM 1959 CG ASP B 67 17.361 9. .920 -25. .070 1. .00 20. .12 c

ANISOU 1959 CG ASP B 67 1990 2539 3115 9 -618 414 c

ATOM 1960 OD1 ASP B 67 18.382 9. ,203 -24. .981 1. .00 18. .57 0

ANISOU 1960 OD1 ASP B 67 1591 2819 2643 -99 -390 663 0

ATOM 1961 OD2 ASP B 67 16.213 9. .450 -25. .235 1. .00 19. .41 0

ANISOU 1961 OD2 ASP B 67 1828 2591 2954 174 -363 -146 0

ATOM 1962 N ALA B 68 20.730 11. .167 -23. .243 1. .00 19. .80 N

ANISOU 1962 N ALA B 68 1808 2916 2798 -232 -584 261 N

ATOM 1963 CA ALA B 68 21.345 10. .804 -21. .977 1. .00 18. .81 C

ANISOU 1963 CA ALA B 68 1896 2444 2806 -397 -491 393 C

ATOM 1964 C ALA B 68 21.124 11. .924 -20. .949 1. .00 18. .58 C

ANISOU 1964 C ALA B 68 1720 2139 3199 -342 -520 351 C

ATOM 1965 O ALA B 68 20.969 13. .097 -21. .310 1. .00 19. .26 O

ANISOU 1965 O ALA B 68 1841 2043 3433 -211 -505 231 0

ATOM 1966 CB ALA B 68 22.823 10. .498 -22. .163 1. .00 20. .72 c

ANISOU 1966 CB ALA B 68 2028 3066 2776 -236 -276 492 c

ATOM 1967 N ILE B 69 21.060 11. .538 -19. .677 1. .00 16. .55 N

ANISOU 1967 N ILE B 69 1656 1629 3001 -74 -597 163 N

ATOM 1968 CA ILE B 69 20.834 12. .472 -18. .580 1. .00 19. .56 C ANISOU 1968 CA ILE B 69 1880 2457 3095 30 -601 -55 C

ATOM 1969 C ILE B 69 22.032 12. ,488 -17. .630 1. .00 17. .55 C

ANISOU 1969 C ILE B 69 2312 1782 2572 -375 -676 198 C

ATOM 1970 O ILE B 69 22.701 11. .463 -17. .421 1. .00 17. .39 O

ANISOU 1970 O ILE B 69 1237 2194 3174 -231 -687 -265 O

ATOM 1971 CB ILE B 69 19.540 12. .138 -17. .794 1. .00 17. .62 C

ANISOU 1971 CB ILE B 69 1437 2416 2841 249 -805 -39 C

ATOM 1972 CGI ILE B 69 19.520 10. .654 -17. .386 1. .00 18. .94 C

ANISOU 1972 CGI ILE B 69 1597 2589 3011 139 -145 228 C

ATOM 1973 CG2 ILE B 69 18.304 12. .498 -18. .622 1. .00 18. .42 C

ANISOU 1973 CG2 ILE B 69 1929 2190 2878 698 -929 90 C

ATOM 1974 CD1 ILE B 69 18.438 10. .268 -16. .398 1. .00 16. .33 C

ANISOU 1974 CD1 ILE B 69 1282 2205 2714 117 -293 -175 C

ATOM 1975 N LYS B 70 22.305 13. .658 -17. .066 1. .00 21. .65 N

ANISOU 1975 N LYS B 70 3011 2091 3120 -346 -1258 -142 N

ATOM 1976 CA LYS B 70 23.366 13. .810 -16. .086 1. .00 19. .78 C

ANISOU 1976 CA LYS B 70 2362 2054 3098 -683 -924 154 C

ATOM 1977 C LYS B 70 22.790 13. .536 -14. .690 1. .00 19. .42 C

ANISOU 1977 C LYS B 70 2005 2552 2821 -388 -1103 -235 C

ATOM 1978 O LYS B 70 21.832 14. .186 -14. .267 1. .00 23. .96 O

ANISOU 1978 O LYS B 70 3077 2586 3438 324 -1041 -295 O

ATOM 1979 CB LYS B 70 23.949 15. .217 -16. .190 1. .00 26. .57 C

ANISOU 1979 CB LYS B 70 4039 2600 3454 -1708 -1190 349 C

ATOM 1980 CG LYS B 70 25.243 15. .431 -15. .442 1. .00 30. .30 c

ANISOU 1980 CG LYS B 70 4180 2846 4483 -2122 -1396 665 c

ATOM 1981 CD LYS B 70 25.724 16. .858 -15. .648 1. .00 38. .65 c

ANISOU 1981 CD LYS B 70 5494 3908 5280 -3884 -1057 860 c

ATOM 1982 CE LYS B 70 27.103 17. .049 -15. .059 1. .00 43. .83 c

ANISOU 1982 CE LYS B 70 5661 4506 6484 -3033 -1424 162 c

ATOM 1983 NZ LYS B 70 27.433 18. ,496 -14. .962 1. .00 50. .25 N

ANISOU 1983 NZ LYS B 70 7508 4579 7004 -3561 -2160 652 N

ATOM 1984 N VAL B 71 23.376 12. .570 -13. .985 1. .00 17. .78 N

ANISOU 1984 N VAL B 71 1859 2318 2577 -207 -500 -391 N

ATOM 1985 CA VAL B 71 22.867 12. .134 -12. .694 1. .00 17. .37 C

ANISOU 1985 CA VAL B 71 1674 2416 2507 -56 -578 -487 C

ATOM 1986 C VAL B 71 23.982 12. .166 -11. .651 1. .00 17. .63 C

ANISOU 1986 C VAL B 71 1426 2707 2566 172 -448 -441 C

ATOM 1987 O VAL B 71 25.152 12. .378 -11. .989 1. .00 19. .00 O

ANISOU 1987 O VAL B 71 1566 3626 2026 -322 -545 -370 O

ATOM 1988 CB VAL B 71 22.259 10. .709 -12. .775 1. .00 14. .61 C

ANISOU 1988 CB VAL B 71 1149 2181 2217 315 -861 -734 C

ATOM 1989 CGI VAL B 71 21.166 10. .646 -13. .845 1. .00 13. .95 C

ANISOU 1989 CGI VAL B 71 581 2216 2503 113 -718 -352 C

ATOM 1990 CG2 VAL B 71 23.349 9. .678 -13. .075 1. .00 13. .64 C

ANISOU 1990 CG2 VAL B 71 1150 1574 2457 0 -398 -425 c

ATOM 1991 N PHE B 72 23.610 11. .989 -10. .389 1. .00 16. .89 N

ANISOU 1991 N PHE B 72 1761 2268 2388 -54 -457 -642 N

ATOM 1992 CA PHE B 72 24.578 11. .694 -9. .356 1. .00 16. .85 C

ANISOU 1992 CA PHE B 72 1793 2212 2394 229 -349 -797 C

ATOM 1993 C PHE B 72 24.613 10. .194 -9. .107 1. .00 17. .97 C

ANISOU 1993 C PHE B 72 1771 2249 2808 126 16 -519 C

ATOM 1994 O PHE B 72 23.591 9. ,588 -8. .779 1. .00 18. .48 O

ANISOU 1994 O PHE B 72 1587 2563 2867 -12 -233 -673 O

ATOM 1995 CB PHE B 72 24.285 12. .438 -8. .040 1. .00 17. .07 c

ANISOU 1995 CB PHE B 72 1962 2128 2393 143 -268 -885 c

ATOM 1996 CG PHE B 72 25.281 12. .128 -6. .942 1. .00 18. .72 c

ANISOU 1996 CG PHE B 72 2374 2379 2359 -45 -326 -612 c

ATOM 1997 CD1 PHE B 72 26.530 12. .759 -6. .907 1. .00 20. .37 c

ANISOU 1997 CD1 PHE B 72 2723 2606 2409 -463 -223 -485 c

ATOM 1998 CD2 PHE B 72 24.990 11. .184 -5. .959 1. .00 18. .94 c

ANISOU 1998 CD2 PHE B 72 2535 2385 2276 0 -72 -598 c ATOM 1999 CE1 PHE B 72 27.452 12..460 -5..907 1..00 19., 58 C

ANISOU 1999 CE1 PHE B 72 2145 2638 2654 -929 -288 -459 C

ATOM 2000 CE2 PHE B 72 25.912 10. ,894 -4. .951 1. .00 20. , 14 C

ANISOU 2000 CE2 PHE B 72 2668 2165 2819 -110 -338 -506 C

ATOM 2001 CZ PHE B 72 27.143 11. .527 -4. .931 1. .00 18. , 33 C

ANISOU 2001 CZ PHE B 72 2691 2034 2237 -90 -529 -622 C

ATOM 2002 N CYS B 73 25.801 9. .612 -9. .257 1. .00 16. , 55 N

ANISOU 2002 N CYS B 73 1544 2435 2307 50 -195 -575 N

ATOM 2003 CA CYS B 73 26.034 8. .225 -8. .907 1. .00 16. , 10 C

ANISOU 2003 CA CYS B 73 1636 2398 2080 31 -150 -372 C

ATOM 2004 C CYS B 73 26.631 8. .141 -7. .509 1. .00 16. , 51 C

ANISOU 2004 C CYS B 73 1981 2281 2011 -61 -12 -250 C

ATOM 2005 O CYS B 73 27.687 8. .717 -7. .244 1. .00 17. , 43 O

ANISOU 2005 O CYS B 73 1855 2529 2235 -43 -107 -293 O

ATOM 2006 CB CYS B 73 27.005 7. .577 -9. .901 1. .00 16. , 83 C

ANISOU 2006 CB CYS B 73 1732 2642 2020 137 -70 -212 C

ATOM 2007 SG CYS B 73 26.396 7. .424 -11. .601 1. .00 15. ,71 S

ANISOU 2007 SG CYS B 73 1309 2442 2216 -102 -143 -268 s

ATOM 2008 N ASN B 74 25.940 7. .432 -6. .619 1. .00 15. , 40 N

ANISOU 2008 N ASN B 74 1753 2404 1694 138 -70 -76 N

ATOM 2009 CA ASN B 74 26.503 7. ,060 -5. .342 1. .00 16. , 65 C

ANISOU 2009 CA ASN B 74 2093 2292 1939 24 -166 201 C

ATOM 2010 C ASN B 74 27.195 5. .730 -5. .588 1. .00 17. , 91 C

ANISOU 2010 C ASN B 74 1784 2505 2516 -46 -391 -318 C

ATOM 2011 O ASN B 74 26.538 4. .704 -5. .692 1. .00 18. , 88 O

ANISOU 2011 O ASN B 74 2384 2007 2782 143 -535 -211 O

ATOM 2012 CB ASN B 74 25.388 6. .902 -4. .294 1. .00 17. , 88 C

ANISOU 2012 CB ASN B 74 2529 2578 1684 206 55 -235 c

ATOM 2013 CG ASN B 74 25.924 6. .512 -2. .923 1. .00 20. , 48 c

ANISOU 2013 CG ASN B 74 2625 3328 1825 451 13 -165 c

ATOM 2014 OD1 ASN B 74 26.997 5. .918 -2. .799 1. .00 19. , 56 0

ANISOU 2014 OD1 ASN B 74 2476 2918 2035 78 -578 432 0

ATOM 2015 ND2 ASN B 74 25.163 6. .830 -1. .881 1. .00 22. , 48 N

ANISOU 2015 ND2 ASN B 74 2601 3943 1997 427 -4 -570 N

ATOM 2016 N MET B 75 28.517 5. .738 -5. .688 1. .00 18. , 65 N

ANISOU 2016 N MET B 75 1783 2306 2994 -445 -253 -260 N

ATOM 2017 CA MET B 75 29.221 4. .514 -6. .027 1. .00 19. , 15 C

ANISOU 2017 CA MET B 75 1839 2599 2834 -443 -377 -559 C

ATOM 2018 C MET B 75 29.447 3. .571 -4. .843 1. .00 22. , 62 C

ANISOU 2018 C MET B 75 2658 2863 3071 -92 -792 -429 C

ATOM 2019 O MET B 75 29.908 2. .443 -5. .031 1. .00 22. , 90 O

ANISOU 2019 O MET B 75 2661 2643 3395 -55 -1093 -234 O

ATOM 2020 CB MET B 75 30.524 4. .818 -6. .778 1. .00 20. , 17 C

ANISOU 2020 CB MET B 75 2113 2599 2950 -582 -61 -466 C

ATOM 2021 CG MET B 75 30.293 5. ,471 -8. .134 1. .00 17. , 75 C

ANISOU 2021 CG MET B 75 1600 1863 3278 -475 -320 -389 C

ATOM 2022 SD MET B 75 29.170 4. .543 -9. .208 1. .00 20. , 90 S

ANISOU 2022 SD MET B 75 2018 2678 3243 -103 -544 -992 s

ATOM 2023 CE MET B 75 30.072 4. .759 -10. .724 1. .00 26. , 36 c

ANISOU 2023 CE MET B 75 3125 3786 3104 -645 -185 -992 c

ATOM 2024 N GLU B 76 29.117 4. .023 -3. .632 1. .00 23. , 82 N

ANISOU 2024 N GLU B 76 3052 3070 2929 -278 -889 -389 N

ATOM 2025 CA GLU B 76 29.108 3. .126 -2. .470 1. .00 25. , 96 C

ANISOU 2025 CA GLU B 76 3460 3447 2956 -354 -1032 -201 C

ATOM 2026 C GLU B 76 27.945 2. .147 -2. .621 1. .00 24. , 70 C

ANISOU 2026 C GLU B 76 3323 2462 3600 140 -1155 356 C

ATOM 2027 O GLU B 76 28.108 0. .945 -2. .434 1. .00 26. , 58 O

ANISOU 2027 O GLU B 76 3713 2578 3807 -95 -1573 911 0

ATOM 2028 CB GLU B 76 29.002 3. .916 -1. .156 1. .00 23. ,46 c

ANISOU 2028 CB GLU B 76 3447 3015 2448 93 -945 367 c

ATOM 2029 N THR B 77 26.783 2. .666 -3. .014 1. .00 24. , 02 N ANISOU 2029 N THR B 77 2606 3469 3051 -430 -1364 171 N

ATOM 2030 CA THR B 77 25.565 1. .858 -3. .094 1. .00 22. .92 C

ANISOU 2030 CA THR B 77 2514 3332 2859 -215 -1480 301 C

ATOM 2031 C THR B 77 25.256 1. .423 -4. .517 1. .00 20. .79 C

ANISOU 2031 C THR B 77 2707 2260 2932 -296 -1070 121 C

ATOM 2032 O THR B 77 24.587 0. .420 -4. .733 1. .00 24. .27 O

ANISOU 2032 O THR B 77 2875 2474 3869 -352 -2127 231 O

ATOM 2033 CB THR B 77 24.348 2. .646 -2. .586 1. .00 25. .86 C

ANISOU 2033 CB THR B 77 3044 3697 3084 -156 -951 24 C

ATOM 2034 OG1 THR B 77 24.219 3. .853 -3. .352 1. .00 23. .95 O

ANISOU 2034 OG1 THR B 77 2489 3471 3138 -404 -880 -94 0

ATOM 2035 CG2 THR B 77 24.494 2. ,984 -1. .091 1. .00 29. .48 c

ANISOU 2035 CG2 THR B 77 3352 4858 2987 308 -1596 301 c

ATOM 2036 N GLY B 78 25.723 2. .208 -5. .478 1. .00 18. .41 N

ANISOU 2036 N GLY B 78 2325 2523 2144 496 -909 238 N

ATOM 2037 CA GLY B 78 25.402 1. .991 -6. .886 1. .00 18. .85 C

ANISOU 2037 CA GLY B 78 2440 2422 2298 61 -981 -10 C

ATOM 2038 C GLY B 78 24.103 2. .640 -7. .319 1. .00 16. .99 C

ANISOU 2038 C GLY B 78 1969 2141 2345 67 -269 -229 C

ATOM 2039 O GLY B 78 23.602 2. .344 -8. .408 1. .00 18. .83 O

ANISOU 2039 O GLY B 78 2122 2667 2365 41 -119 -446 O

ATOM 2040 N GLU B 79 23.576 3. .556 -6. .499 1. .00 15. .90 N

ANISOU 2040 N GLU B 79 1593 2297 2150 230 -558 -191 N

ATOM 2041 CA GLU B 79 22.344 4. .264 -6. .838 1. .00 14. .59 C

ANISOU 2041 CA GLU B 79 1476 2238 1829 181 -240 -214 C

ATOM 2042 C GLU B 79 22.533 5. .367 -7. .859 1. .00 14. .02 C

ANISOU 2042 C GLU B 79 1630 2077 1620 108 -335 -312 C

ATOM 2043 O GLU B 79 23.566 6. .091 -7. .872 1. .00 16. .41 O

ANISOU 2043 O GLU B 79 1602 2488 2142 52 -488 -182 O

ATOM 2044 CB GLU B 79 21.689 4. .867 -5. .596 1. .00 16. .61 C

ANISOU 2044 CB GLU B 79 1702 2937 1669 42 -7 -121 C

ATOM 2045 CG GLU B 79 21.172 3. .855 -4. .590 1. .00 20. .12 c

ANISOU 2045 CG GLU B 79 2200 3387 2057 -308 31 164 c

ATOM 2046 CD GLU B 79 20.954 4. .493 -3. .233 1. .00 25. .01 c

ANISOU 2046 CD GLU B 79 2720 4261 2518 -659 -215 -642 c

ATOM 2047 OE1 GLU B 79 21.937 4. .926 -2. .598 1. .00 25. .90 0

ANISOU 2047 OE1 GLU B 79 3005 4504 2329 -917 -343 -612 0

ATOM 2048 OE2 GLU B 79 19.793 4. .570 -2. .797 1. .00 30. .37 0

ANISOU 2048 OE2 GLU B 79 2987 5350 3203 -117 73 -245 0

ATOM 2049 N THR B 80 21.506 5. ,494 -8. .700 1. .00 14. .17 N

ANISOU 2049 N THR B 80 1575 2230 1577 78 -243 -82 N

ATOM 2050 CA THR B 80 21.386 6. .543 -9. .692 1. .00 12. .75 C

ANISOU 2050 CA THR B 80 1235 1899 1708 310 -307 -168 C

ATOM 2051 C THR B 80 20.422 7. .559 -9. .108 1. .00 15. .33 C

ANISOU 2051 C THR B 80 1857 1904 2062 150 -16 -598 C

ATOM 2052 O THR B 80 19.244 7. .243 -8. .881 1. .00 15. .54 0

ANISOU 2052 O THR B 80 1632 2125 2146 459 16 -213 0

ATOM 2053 CB THR B 80 20.805 5. .950 -10. .994 1. .00 13. .73 c

ANISOU 2053 CB THR B 80 1595 1818 1802 241 -447 -99 c

ATOM 2054 OG1 THR B 80 21.689 4. .921 -11. .484 1. .00 14. .10 0

ANISOU 2054 OG1 THR B 80 1582 2046 1730 99 -327 -386 0

ATOM 2055 CG2 THR B 80 20.578 7. ,027 -12. .054 1. .00 14. .59 c

ANISOU 2055 CG2 THR B 80 1647 2245 1649 159 -192 79 c

ATOM 2056 N CYS B 81 20.910 8. .768 -8. .860 1. .00 14. .62 N

ANISOU 2056 N CYS B 81 1408 2014 2132 139 -61 -928 N

ATOM 2057 CA CYS B 81 20.117 9. .781 -8. .148 1. .00 13. .69 C

ANISOU 2057 CA CYS B 81 1285 1687 2227 57 102 -657 C

ATOM 2058 C CYS B 81 19.813 10. .964 -9. .050 1. .00 15. .76 C

ANISOU 2058 C CYS B 81 1614 2222 2149 154 -30 -432 C

ATOM 2059 O CYS B 81 20.721 11. .599 -9. .611 1. .00 14. .98 0

ANISOU 2059 O CYS B 81 1400 1937 2355 85 -327 -298 0 ATOM 2060 CB CYS B 81 20.818 10..238 -6..864 1..00 17..48 C

ANISOU 2060 CB CYS B 81 1779 2653 2208 200 -195 -577 C

ATOM 2061 SG CYS B 81 21.023 8. .940 -5. .618 1. .00 21. .08 S

ANISOU 2061 SG CYS B 81 2091 3016 2901 29 -459 -213 S

ATOM 2062 N ILE B 82 18.525 11. .259 -9. .178 1. .00 15. .12 N

ANISOU 2062 N ILE B 82 1502 1865 2379 42 157 -365 N

ATOM 2063 CA ILE B 82 18.054 12. .326 -10. .060 1. .00 16. .81 C

ANISOU 2063 CA ILE B 82 2094 1960 2332 123 95 -304 C

ATOM 2064 C ILE B 82 17.434 13. ,448 -9. .223 1. .00 16. .14 C

ANISOU 2064 C ILE B 82 1779 1872 2480 -101 307 -272 C

ATOM 2065 O ILE B 82 16.488 13. .228 -8. .433 1. .00 15. .39 O

ANISOU 2065 O ILE B 82 2039 1765 2043 -166 341 -350 O

ATOM 2066 CB ILE B 82 17.045 11. .786 -11. .098 1. .00 16. .05 C

ANISOU 2066 CB ILE B 82 2019 1652 2427 239 242 -553 C

ATOM 2067 CGI ILE B 82 17.654 10. .645 -11. .916 1. .00 18. .40 c

ANISOU 2067 CGI ILE B 82 2249 2234 2508 378 107 -985 c

ATOM 2068 CG2 ILE B 82 16.537 12. .894 -12. .016 1. .00 18. .66 c

ANISOU 2068 CG2 ILE B 82 2929 1839 2319 17 -86 -400 c

ATOM 2069 CD1 ILE B 82 16.629 9. .903 -12. .735 1. .00 24. .95 c

ANISOU 2069 CD1 ILE B 82 3320 2473 3687 6 -374 - 1363 c

ATOM 2070 N SER B 83 17.969 14. .653 -9. .389 1. .00 15. .52 N

ANISOU 2070 N SER B 83 1987 1364 2544 274 -79 -442 N

ATOM 2071 CA SER B 83 17.499 15. .801 -8. .617 1. .00 16. .39 C

ANISOU 2071 CA SER B 83 1782 1964 2479 139 250 -787 C

ATOM 2072 C SER B 83 16.185 16. .381 -9. .100 1. .00 15. .65 C

ANISOU 2072 C SER B 83 1703 2023 2220 -77 274 -697 C

ATOM 2073 O SER B 83 15.922 16. .421 -10. .297 1. .00 16. .95 O

ANISOU 2073 O SER B 83 1926 2292 2220 -332 64 -621 0

ATOM 2074 CB SER B 83 18.554 16. .903 -8. .608 1. .00 16. .03 c

ANISOU 2074 CB SER B 83 1040 2298 2752 269 93 -606 c

ATOM 2075 OG SER B 83 19.714 16. .424 -7. .960 1. .00 20. .85 0

ANISOU 2075 OG SER B 83 1215 3003 3704 326 -269 -321 0

ATOM 2076 N ALA B 84 15.373 16. .854 -8. .153 1. .00 15. .30 N

ANISOU 2076 N ALA B 84 1446 2033 2334 89 381 -496 N

ATOM 2077 CA ALA B 84 14.201 17. .664 -8. .494 1. .00 15. .10 C

ANISOU 2077 CA ALA B 84 1473 2414 1847 126 588 -84 C

ATOM 2078 C ALA B 84 14.610 18. ,981 -9. .138 1. .00 16. .72 C

ANISOU 2078 C ALA B 84 1950 2131 2270 6 11 -257 C

ATOM 2079 O ALA B 84 15.660 19. .569 -8. .809 1. .00 17. .86 O

ANISOU 2079 O ALA B 84 1989 2493 2304 -187 -34 -193 0

ATOM 2080 CB ALA B 84 13.345 17. .917 -7. .252 1. .00 15. .57 c

ANISOU 2080 CB ALA B 84 1846 2012 2055 275 732 -418 c

ATOM 2081 N ASN B 85 13.797 19. .427 -10. .087 1. .00 17. .17 N

ANISOU 2081 N ASN B 85 1942 2337 2242 118 165 154 N

ATOM 2082 CA ASN B 85 13.999 20. .718 -10. .714 1. .00 21. .33 C

ANISOU 2082 CA ASN B 85 2997 2392 2713 -179 25 197 C

ATOM 2083 C ASN B 85 12.650 21. .310 -11. .131 1. .00 22. .52 C

ANISOU 2083 C ASN B 85 2977 2856 2724 -258 -251 153 C

ATOM 2084 O ASN B 85 12.045 20. .828 -12. .093 1. .00 29. .45 O

ANISOU 2084 O ASN B 85 4643 4201 2345 271 -1002 22 O

ATOM 2085 CB ASN B 85 14.936 20. .577 -11. .918 1. .00 24. .41 c

ANISOU 2085 CB ASN B 85 3373 2822 3079 -471 426 301 c

ATOM 2086 CG ASN B 85 15.584 21. .889 -12. .315 1. .00 27. .40 c

ANISOU 2086 CG ASN B 85 3981 2411 4019 -480 620 -236 c

ATOM 2087 OD1 ASN B 85 14.994 22. .963 -12. .173 1. .00 30. .13 0

ANISOU 2087 OD1 ASN B 85 4695 2637 4113 195 500 216 0

ATOM 2088 ND2 ASN B 85 16.808 21. .807 -12. .830 1. .00 30. .25 N

ANISOU 2088 ND2 ASN B 85 3781 4508 3205 -1368 406 -490 N

ATOM 2089 N PRO B 86 12.181 22. ,365 -10. .425 1. .00 25. .20 N

ANISOU 2089 N PRO B 86 2651 3479 3442 346 -62 43 N

ATOM 2090 CA PRO B 86 12.832 23. .073 -9. .307 1. .00 25. .18 C ANISOU 2090 CA PRO B 86 2990 3404 3172 534 -59 -7 C

ATOM 2091 C PRO B 86 12.882 22. .196 -8. .056 1. .00 22. .57 C

ANISOU 2091 C PRO B 86 2839 2970 2764 468 382 -344 C

ATOM 2092 O PRO B 86 12.048 21. .327 -7. .900 1. .00 24. .61 O

ANISOU 2092 O PRO B 86 3256 2697 3395 189 93 -656 O

ATOM 2093 CB PRO B 86 11.915 24. .276 -9. .070 1. .00 28. .07 C

ANISOU 2093 CB PRO B 86 3496 2650 4518 -2 439 -421 C

ATOM 2094 CG PRO B 86 10.589 23. .848 -9. .575 1. .00 29. .08 C

ANISOU 2094 CG PRO B 86 3201 3561 4286 882 170 -652 C

ATOM 2095 CD PRO B 86 10.863 22. .949 -10. .744 1. .00 26. .58 C

ANISOU 2095 CD PRO B 86 3184 3285 3630 761 -647 -434 C

ATOM 2096 N LEU B 87 13.852 22. .387 -7. .172 1. .00 23. .40 N

ANISOU 2096 N LEU B 87 3234 3258 2396 601 393 -440 N

ATOM 2097 CA LEU B 87 13.863 21. .504 -5. .989 1. .00 26. .33 C

ANISOU 2097 CA LEU B 87 3439 3717 2846 -113 7 -89 C

ATOM 2098 C LEU B 87 13.281 22. ,110 -4. .717 1. .00 23. .71 C

ANISOU 2098 C LEU B 87 2514 3739 2756 -117 -328 -311 C

ATOM 2099 O LEU B 87 13.183 21. .430 -3. .697 1. .00 27. .60 O

ANISOU 2099 O LEU B 87 3732 3319 3436 -504 227 -260 O

ATOM 2100 CB LEU B 87 15.243 20. .895 -5. .726 1. .00 30. .02 C

ANISOU 2100 CB LEU B 87 2993 4396 4014 -468 220 -400 C

ATOM 2101 CG LEU B 87 16.479 21. .775 -5. .903 1. .00 34. .04 c

ANISOU 2101 CG LEU B 87 2782 5189 4960 -1249 -1166 - 1141 c

ATOM 2102 CD1 LEU B 87 16.390 23. .008 -5. .026 1. .00 37. .30 c

ANISOU 2102 CD1 LEU B 87 4380 4859 4932 -813 76 -726 c

ATOM 2103 CD2 LEU B 87 17.730 20. .978 -5. .580 1. .00 38. .85 c

ANISOU 2103 CD2 LEU B 87 3871 6114 4773 630 157 - 1626 c

ATOM 2104 N ASN B 88 12.881 23. ,379 -4. .811 1. .00 21. .46 N

ANISOU 2104 N ASN B 88 2497 3450 2206 -415 -397 -633 N

ATOM 2105 CA ASN B 88 12.444 24. .196 -3. .679 1. .00 22. .15 C

ANISOU 2105 CA ASN B 88 2302 3317 2796 -12 338 -445 C

ATOM 2106 C ASN B 88 11.032 24. .746 -3. .878 1. .00 19. .58 C

ANISOU 2106 C ASN B 88 2407 2877 2155 -264 -103 -679 C

ATOM 2107 O ASN B 88 10.699 25. .225 -4. .963 1. .00 20. .31 O

ANISOU 2107 O ASN B 88 2655 2824 2237 631 343 -422 0

ATOM 2108 CB ASN B 88 13.438 25. .363 -3. .502 1. .00 31. .26 c

ANISOU 2108 CB ASN B 88 4205 3846 3824 -924 -486 - 1358 c

ATOM 2109 CG ASN B 88 13.104 26. .261 -2. .323 1. .00 36. .85 c

ANISOU 2109 CG ASN B 88 4478 5099 4422 -28 -58 - 1489 c

ATOM 2110 OD1 ASN B 88 13.354 25. .906 -1. .168 1. .00 45. .49 0

ANISOU 2110 OD1 ASN B 88 4353 7216 5712 -304 -1638 -241 0

ATOM 2111 ND2 ASN B 88 12.571 27. .452 -2. .612 1. .00 42. .02 N

ANISOU 2111 ND2 ASN B 88 5790 4202 5972 -1007 -651 - 1229 N

ATOM 2112 N VAL B 89 10.213 24. .664 -2. .828 1. .00 20. .15 N

ANISOU 2112 N VAL B 89 2365 2719 2569 278 241 -364 N

ATOM 2113 CA VAL B 89 8.957 25. .419 -2. .719 1. .00 21. .08 C

ANISOU 2113 CA VAL B 89 2865 2455 2687 524 205 -615 C

ATOM 2114 C VAL B 89 9.282 26. .514 -1. .700 1. .00 19. .67 C

ANISOU 2114 C VAL B 89 2523 2453 2496 389 53 -429 C

ATOM 2115 O VAL B 89 9.577 26. .206 -0. .547 1. .00 20. .68 O

ANISOU 2115 O VAL B 89 1854 3276 2725 88 -30 56 O

ATOM 2116 CB VAL B 89 7.792 24. .543 -2. .190 1. .00 18. .17 C

ANISOU 2116 CB VAL B 89 2310 2369 2225 743 121 -670 C

ATOM 2117 CGI VAL B 89 6.557 25. .383 -1. .850 1. .00 17. .68 C

ANISOU 2117 CGI VAL B 89 2283 2119 2315 648 146 -385 C

ATOM 2118 CG2 VAL B 89 7.446 23. ,415 -3. .168 1. .00 19. .36 c

ANISOU 2118 CG2 VAL B 89 2687 2364 2305 523 142 -616 c

ATOM 2119 N PRO B 90 9.252 27. .790 -2. .121 1. .00 22. .10 N

ANISOU 2119 N PRO B 90 3290 2528 2579 130 -273 -165 N

ATOM 2120 CA PRO B 90 9.559 28. .884 -1. .184 1. .00 21. .38 C

ANISOU 2120 CA PRO B 90 3380 2412 2330 183 -257 -56 C ATOM 2121 C PRO B 90 8.708 28..846 0..089 1..00 23..45 C

ANISOU 2121 C PRO B 90 3202 3000 2708 -280 -115 -229 C

ATOM 2122 O PRO B 90 7.557 28. .361 0. .067 1. .00 22. .92 O

ANISOU 2122 O PRO B 90 2939 2659 3109 33 156 204 O

ATOM 2123 CB PRO B 90 9.252 30. .153 -1. ,997 1. ,00 23. , 43 C

ANISOU 2123 CB PRO B 90 3557 2672 2672 367 -58 261 C

ATOM 2124 CG PRO B 90 9.406 29. .734 -3. ,415 1. ,00 25. , 97 C

ANISOU 2124 CG PRO B 90 4626 2347 2894 -505 -368 -251 C

ATOM 2125 CD PRO B 90 8.971 28. .289 -3. ,480 1. ,00 22. , 34 C

ANISOU 2125 CD PRO B 90 4172 1958 2357 196 -208 -310 C

ATOM 2126 N ARG B 91 9.276 29. .354 1. .181 1. .00 20. .40 N

ANISOU 2126 N ARG B 91 2645 2831 2275 -457 -144 355 N

ATOM 2127 CA ARG B 91 8.571 29. .463 2. .457 1. .00 23. .87 C

ANISOU 2127 CA ARG B 91 2883 3425 2759 66 152 -128 C

ATOM 2128 C ARG B 91 7.584 30. .638 2. .415 1. .00 23. .48 C

ANISOU 2128 C ARG B 91 3155 2284 3482 -495 709 183 C

ATOM 2129 O ARG B 91 7.981 31. ,770 2. ,132 1. ,00 24. , 60 O

ANISOU 2129 O ARG B 91 3232 2219 3894 -400 1098 181 O

ATOM 2130 CB ARG B 91 9.583 29. .632 3. .595 1. .00 22. .14 C

ANISOU 2130 CB ARG B 91 2238 3636 2538 -41 423 132 C

ATOM 2131 CG ARG B 91 10.407 28. .372 3. .859 1. .00 25. .25 c

ANISOU 2131 CG ARG B 91 2719 3311 3564 -373 -135 315 c

ATOM 2132 CD ARG B 91 11.434 28. .572 4. .958 1. .00 30. .47 c

ANISOU 2132 CD ARG B 91 2681 5174 3720 -934 -102 190 c

ATOM 2133 NE ARG B 91 11.971 29. .927 4. .943 1. .00 37. .77 N

ANISOU 2133 NE ARG B 91 2836 6016 5499 -1513 -989 509 N

ATOM 2134 CZ ARG B 91 12.652 30. .485 5. .941 1. .00 43. .53 C

ANISOU 2134 CZ ARG B 91 2279 8660 5597 -1863 -1362 418 C

ATOM 2135 NH1 ARG B 91 12.911 29. ,802 7. ,047 1. ,00 46. , 22 N

ANISOU 2135 NH1 ARG B 91 3888 10036 3636 -1841 451 -260 N

ATOM 2136 NH2 ARG B 91 13.086 31. .730 5. .823 1. .00 48. .39 N

ANISOU 2136 NH2 ARG B 91 4526 7514 6344 -548 -1979 38 N

ATOM 2137 N LYS B 92 6.304 30. .360 2. .697 1. .00 24. .84 N

ANISOU 2137 N LYS B 92 2620 3347 3467 -4 170 -86 N

ATOM 2138 CA LYS B 92 5.222 31. .309 2. .449 1. ,00 25. , 35 C

ANISOU 2138 CA LYS B 92 2773 3087 3770 32 629 -497 C

ATOM 2139 C LYS B 92 3.968 30. .858 3. .176 1. .00 21. .43 C

ANISOU 2139 C LYS B 92 2253 2601 3288 510 418 -808 C

ATOM 2140 O LYS B 92 3.848 29. .674 3. .536 1. .00 20. .92 O

ANISOU 2140 O LYS B 92 2012 2927 3009 110 592 -497 O

ATOM 2141 CB LYS B 92 4.924 31. .318 0. .941 1. .00 31. .49 C

ANISOU 2141 CB LYS B 92 4284 3979 3699 265 945 212 C

ATOM 2142 CG LYS B 92 4.267 32. .570 0. .401 1. .00 36. .85 C

ANISOU 2142 CG LYS B 92 4683 4879 4437 -68 498 1016 C

ATOM 2143 CD LYS B 92 4.329 32. .596 -1. ,120 1. ,00 38. , 93 C

ANISOU 2143 CD LYS B 92 4608 5954 4230 -244 288 717 C

ATOM 2144 CE LYS B 92 3.148 31. ,872 -1. ,733 1. ,00 37. , 47 C

ANISOU 2144 CE LYS B 92 5663 4373 4198 -261 150 349 C

ATOM 2145 NZ LYS B 92 2.878 32. .384 -3. ,105 1. ,00 46. , 87 N

ANISOU 2145 NZ LYS B 92 7170 6242 4394 -427 691 1256 N

ATOM 2146 N HIS B 93 3.046 31. .799 3. .395 1. .00 21. .85 N

ANISOU 2146 N HIS B 93 2737 2352 3214 654 107 -895 N

ATOM 2147 CA HIS B 93 1.652 31. .468 3. .679 1. .00 22. .24 C

ANISOU 2147 CA HIS B 93 3019 2653 2777 525 252 - 1202 C

ATOM 2148 C HIS B 93 1.013 31. .080 2. .363 1. .00 21. .94 C

ANISOU 2148 C HIS B 93 3359 2221 2754 373 19 -739 C

ATOM 2149 O HIS B 93 0.740 31. .941 1. .530 1. .00 27. .90 O

ANISOU 2149 O HIS B 93 4748 2569 3283 661 -175 -347 O

ATOM 2150 CB HIS B 93 0.933 32. .675 4. .300 1. .00 21. .98 C

ANISOU 2150 CB HIS B 93 2858 2493 2998 729 90 -891 C

ATOM 2151 CG HIS B 93 -0.492 32. ,405 4. ,684 1. ,00 25. ,16 C ANISOU 2151 CG HIS B 93 3158 3523 2876 884 762 -952 C

ATOM 2152 ND1 HIS B 93 -0.821 31. ,634 5. .735 1. .00 27. ,76 N

ANISOU 2152 ND1 HIS B 93 3013 4968 2564 673 373 -528 N

ATOM 2153 CD2 HIS B 93 -1.693 32. ,824 4. .111 1. .00 28. ,11 C

ANISOU 2153 CD2 HIS B 93 3562 3576 3540 1268 560 -366 C

ATOM 2154 CE1 HIS B 93 -2.171 31. ,572 5. .844 1. .00 25. , 90 C

ANISOU 2154 CE1 HIS B 93 2919 4718 2203 1478 1001 -669 C

ATOM 2155 NE2 HIS B 93 -2.701 32. ,296 4. .848 1. .00 31. , 50 N

ANISOU 2155 NE2 HIS B 93 3129 4865 3973 1492 449 182 N

ATOM 2156 N TRP B 94 0.768 29. .785 2, .169 1, .00 19. .47 N

ANISOU 2156 N TRP B 94 2819 2245 2331 568 -55 - 1067 N

ATOM 2157 CA TRP B 94 0.330 29. .246 0, .877 1, .00 19. .68 C

ANISOU 2157 CA TRP B 94 2686 2795 1995 569 371 - 1111 C

ATOM 2158 C TRP B 94 -1.159 29. ,097 0. .702 1. .00 22. , 58 C

ANISOU 2158 C TRP B 94 2594 3414 2571 1193 423 -840 C

ATOM 2159 O TRP B 94 -1.671 29. ,130 -0. .424 1. .00 23. , 72 O

ANISOU 2159 O TRP B 94 2050 3573 3388 1061 -179 -510 O

ATOM 2160 CB TRP B 94 0.984 27. .878 0, .640 1, .00 20. .54 C

ANISOU 2160 CB TRP B 94 2580 2402 2823 404 109 -618 C

ATOM 2161 CG TRP B 94 2.413 27. .947 0, .161 1, .00 19. .27 C

ANISOU 2161 CG TRP B 94 2597 2609 2114 496 57 -594 C

ATOM 2162 CD1 TRP B 94 3.585 27. .743 0, .909 1, .00 20. .14 C

ANISOU 2162 CD1 TRP B 94 2139 2460 3052 485 106 -624 C

ATOM 2163 CD2 TRP B 94 2.878 28. .268 -1. .194 1. .00 19. , 96 C

ANISOU 2163 CD2 TRP B 94 2418 2780 2385 754 536 -522 C

ATOM 2164 NE1 TRP B 94 4.699 27. .909 0, .119 1, .00 20. .14 N

ANISOU 2164 NE1 TRP B 94 2284 2617 2748 716 104 -740 N

ATOM 2165 CE2 TRP B 94 4.349 28. .218 -1. .149 1. .00 20. , 83 C

ANISOU 2165 CE2 TRP B 94 2434 2615 2863 275 300 26 C

ATOM 2166 CE3 TRP B 94 2.248 28. .557 -2. .402 1. .00 20. ,01 C

ANISOU 2166 CE3 TRP B 94 2542 2345 2713 244 117 -454 C

ATOM 2167 CZ2 TRP B 94 5.125 28. .456 -2. .273 1. .00 22. , 10 C

ANISOU 2167 CZ2 TRP B 94 3013 2622 2762 725 569 -126 C

ATOM 2168 CZ3 TRP B 94 3.045 28. .805 -3. .527 1. .00 20. , 56 C

ANISOU 2168 CZ3 TRP B 94 2760 2402 2647 364 31 -135 C

ATOM 2169 CH2 TRP B 94 4.450 28. .755 -3. .460 1. .00 22. , 43 c

ANISOU 2169 CH2 TRP B 94 2757 2661 3101 578 356 -60 c

ATOM 2170 N TRP B 95 -1.859 28. ,891 1. .811 1. .00 21. , 91 N

ANISOU 2170 N TRP B 95 2359 3286 2676 919 393 -990 N

ATOM 2171 CA TRP B 95 -3.246 28. ,431 1. .793 1. .00 21. , 12 C

ANISOU 2171 CA TRP B 95 2413 2675 2935 1010 263 -789 C

ATOM 2172 C TRP B 95 -4.080 29. ,204 2. .770 1. .00 22. , 75 C

ANISOU 2172 C TRP B 95 1687 3577 3379 1158 349 -858 C

ATOM 2173 O TRP B 95 -3.602 29. ,572 3. .840 1. .00 32. , 04 O

ANISOU 2173 O TRP B 95 3746 4935 3493 979 8 -862 O

ATOM 2174 CB TRP B 95 -3.267 26. ,948 2. .138 1. .00 23. , 77 C

ANISOU 2174 CB TRP B 95 2781 2524 3727 463 142 - 1079 c

ATOM 2175 CG TRP B 95 -4.636 26. ,333 2. .113 1. .00 23. , 17 c

ANISOU 2175 CG TRP B 95 2252 2976 3574 962 -293 -981 c

ATOM 2176 CD1 TRP B 95 -5.369 25. ,831 3. .190 1. .00 25. , 70 c

ANISOU 2176 CD1 TRP B 95 1954 3502 4309 299 -309 -809 c

ATOM 2177 CD2 TRP B 95 -5.494 26. ,148 0. .938 1. .00 24. , 95 c

ANISOU 2177 CD2 TRP B 95 2351 3195 3933 893 -589 - 1199 c

ATOM 2178 NE1 TRP B 95 -6.587 25. ,353 2. .768 1. .00 24. , 57 N

ANISOU 2178 NE1 TRP B 95 1863 3162 4309 916 -676 - 1308 N

ATOM 2179 CE2 TRP B 95 -6.725 25. ,514 1. .426 1. .00 28. , 24 C

ANISOU 2179 CE2 TRP B 95 2866 3608 4255 970 -132 -858 C

ATOM 2180 CE3 TRP B 95 -5.368 26. ,433 -0. .421 1. .00 26. , 95 C

ANISOU 2180 CE3 TRP B 95 2801 3249 4186 1021 49 -775 C

ATOM 2181 CZ2 TRP B 95 -7.770 25. ,186 0. .570 1. .00 31. , 03 c

ANISOU 2181 CZ2 TRP B 95 3186 4923 3679 1355 -245 -954 c ATOM 2182 CZ3 TRP B 95 -6.430 26.,100 -1..275 1..00 33..22 C

ANISOU 2182 CZ3 TRP B 95 3593 4564 4462 188 -224 -734 C

ATOM 2183 CH2 TRP B 95 -7.602 25. ,494 -0. .789 1. .00 33. .91 C

ANISOU 2183 CH2 TRP B 95 3743 5001 4137 983 1044 -590 C

ATOM 2184 N THR B 96 -5.331 29. ,480 2. .414 1. .00 21. .56 N

ANISOU 2184 N THR B 96 1509 3281 3399 802 315 - 1058 N

ATOM 2185 CA THR B 96 -6.239 30. ,132 3. .353 1. .00 23. .98 C

ANISOU 2185 CA THR B 96 2052 3556 3500 885 732 -923 C

ATOM 2186 C THR B 96 -7.411 29. ,206 3. .684 1. .00 32. .25 C

ANISOU 2186 C THR B 96 2801 4946 4504 -63 40 -711 C

ATOM 2187 O THR B 96 -8.227 28. ,889 2. .808 1. .00 34. .17 O

ANISOU 2187 O THR B 96 2740 5634 4606 659 -222 - 1390 O

ATOM 2188 CB THR B 96 -6.724 31. ,488 2. .811 1. .00 26. .12 C

ANISOU 2188 CB THR B 96 2285 3276 4360 443 581 -671 C

ATOM 2189 OG1 THR B 96 -5.598 32. ,375 2. .685 1. .00 22. .54 O

ANISOU 2189 OG1 THR B 96 2576 3112 2876 162 669 -904 O

ATOM 2190 CG2 THR B 96 -7.780 32. ,111 3. .745 1. .00 30. .83 c

ANISOU 2190 CG2 THR B 96 3266 4527 3919 429 991 - 1048 c

ATOM 2191 N ASP B 97 -7.471 28. ,771 4. .945 1. .00 31. .62 N

ANISOU 2191 N ASP B 97 2166 5292 4556 1131 536 -208 N

ATOM 2192 CA ASP B 97 -8.492 27. ,848 5. .402 1. .00 35. .47 C

ANISOU 2192 CA ASP B 97 1930 5903 5642 1119 981 -359 C

ATOM 2193 C ASP B 97 -9.738 28. ,628 5. .864 1. .00 40. .28 C

ANISOU 2193 C ASP B 97 2127 6104 7074 1611 878 -162 C

ATOM 2194 O ASP B 97 -9.667 29. ,451 6. .786 1. .00 41. .77 O

ANISOU 2194 O ASP B 97 3056 6489 6322 1230 604 37 O

ATOM 2195 CB ASP B 97 -7.934 26. ,949 6. .517 1. .00 42. .29 c

ANISOU 2195 CB ASP B 97 2787 6441 6840 1445 215 -168 c

ATOM 2196 CG ASP B 97 -8.970 25. ,977 7. .091 1. .00 55. .34 c

ANISOU 2196 CG ASP B 97 5526 7672 7825 86 991 455 c

ATOM 2197 OD1 ASP B 97 -9.910 25. ,553 6. .373 1. .00 49. .23 0

ANISOU 2197 OD1 ASP B 97 3719 7381 7604 -448 3172 -922 0

ATOM 2198 OD2 ASP B 97 -8.823 25. ,624 8. .281 1. .00 59. .28 0

ANISOU 2198 OD2 ASP B 97 6936 8194 7393 -1321 2180 927 0

ATOM 2199 N SER B 98 -10.861 28. ,378 5. .191 1. .00 44. .92 N

ANISOU 2199 N SER B 98 3153 6796 7118 -765 666 14 N

ATOM 2200 CA SER B 98 -12.145 28. ,992 5. .540 1. .00 43. .93 C

ANISOU 2200 CA SER B 98 3770 6763 6158 -5 145 538 C

ATOM 2201 C SER B 98 -13.242 27. ,942 5. .749 1. .00 47. .51 C

ANISOU 2201 C SER B 98 3604 7779 6666 -298 1093 684 C

ATOM 2202 O SER B 98 -14.433 28. ,238 5. .604 1. .00 51. .31 0

ANISOU 2202 O SER B 98 4384 9667 5442 448 -1807 98 0

ATOM 2203 CB SER B 98 -12.571 30. ,008 4. .473 1. .00 47. .92 c

ANISOU 2203 CB SER B 98 6249 6619 5339 -158 -912 26 c

ATOM 2204 OG SER B 98 -12.542 29. ,438 3. .180 1. .00 44. .59 0

ANISOU 2204 OG SER B 98 5444 7232 4265 927 -1256 912 0

ATOM 2205 N SER B 99 -12.833 26. ,721 6. .092 1. .00 50. .22 N

ANISOU 2205 N SER B 99 5475 6976 6631 -717 1119 164 N

ATOM 2206 CA SER B 99 -13.776 25. ,638 6. .367 1. .00 47. .59 C

ANISOU 2206 CA SER B 99 6464 6245 5370 -915 -29 249 C

ATOM 2207 C SER B 99 -13.782 25. ,273 7. .849 1. .00 55. .44 C

ANISOU 2207 C SER B 99 8218 7095 5750 328 34 1128 C

ATOM 2208 O SER B 99 -14.685 24. ,581 8. .322 1. .00 60. .85 O

ANISOU 2208 O SER B 99 8720 6595 7802 -301 -496 1747 0

ATOM 2209 CB SER B 99 -13.442 24. ,410 5. .520 1. .00 52. .57 c

ANISOU 2209 CB SER B 99 6978 7277 5718 -759 847 -407 c

ATOM 2210 OG SER B 99 -13.495 24. ,732 4. .144 1. .00 54. .35 0

ANISOU 2210 OG SER B 99 5091 9446 6112 -1579 1288 -56 0

ATOM 2211 N LYS B 102 -11.334 21. ,310 8. .166 1. .00 37. .98 N

ANISOU 2211 N LYS B 102 4266 4301 5862 1491 824 153 N

ATOM 2212 CA LYS B 102 -9.914 20. ,969 8. .253 1. .00 32. .95 C ANISOU 2212 CA LYS B 102 4091 4872 3557 443 4 -346 C

ATOM 2213 C LYS B 102 -9.554 19. ,628 7. .588 1. .00 36. .29 C

ANISOU 2213 C LYS B 102 4386 4731 4669 299 1355 -149 C

ATOM 2214 O LYS B 102 -9.958 18. ,550 8. .047 1. .00 38. .47 O

ANISOU 2214 O LYS B 102 4248 4649 5721 381 1368 -224 O

ATOM 2215 CB LYS B 102 -9.439 20. ,999 9. .707 1. .00 28. .42 C

ANISOU 2215 CB LYS B 102 3128 4009 3661 112 -24 -161 C

ATOM 2216 CG LYS B 102 -7.966 21. ,345 9. .872 1. .00 28. .92 C

ANISOU 2216 CG LYS B 102 3040 4119 3828 -145 734 179 C

ATOM 2217 CD LYS B 102 -7.516 22. ,289 8. .761 1. .00 28. .77 C

ANISOU 2217 CD LYS B 102 4065 3518 3348 -207 -394 355 C

ATOM 2218 CE LYS B 102 -6.541 23. ,344 9. .243 1. .00 27. .13 C

ANISOU 2218 CE LYS B 102 3202 3856 3247 74 -334 -144 C

ATOM 2219 NZ LYS B 102 -5.974 22. ,977 10. .574 1. .00 31. .36 N

ANISOU 2219 NZ LYS B 102 4386 4489 3040 179 67 416 N

ATOM 2220 N LYS B 103 -8.766 19. ,712 6. .519 1. .00 38. .92 N

ANISOU 2220 N LYS B 103 5447 4858 4483 1434 1752 -739 N

ATOM 2221 CA LYS B 103 -8.426 18. ,548 5. .713 1. .00 29. .64 C

ANISOU 2221 CA LYS B 103 3079 5127 3054 466 1924 -721 C

ATOM 2222 C LYS B 103 -7.066 18. ,733 5. .033 1. .00 25. .36 C

ANISOU 2222 C LYS B 103 2488 3981 3164 231 1348 -882 C

ATOM 2223 O LYS B 103 -6.539 19. ,849 4. .953 1. .00 29. .56 O

ANISOU 2223 O LYS B 103 3645 3556 4030 492 1265 -745 O

ATOM 2224 CB LYS B 103 -9.512 18. ,306 4. .657 1. .00 31. .14 C

ANISOU 2224 CB LYS B 103 3071 4763 3997 604 1037 245 C

ATOM 2225 CG LYS B 103 -9.630 19. ,403 3. .604 1. .00 33. .15 C

ANISOU 2225 CG LYS B 103 4326 4435 3834 -86 1944 247 C

ATOM 2226 N HIS B 104 -6.505 17. ,636 4. .536 1. .00 23. .85 N

ANISOU 2226 N HIS B 104 1924 4287 2848 461 928 -917 N

ATOM 2227 CA HIS B 104 -5.300 17. ,720 3. .679 1. .00 19. .17 C

ANISOU 2227 CA HIS B 104 1310 3655 2318 282 341 -883 C

ATOM 2228 C HIS B 104 -5.578 18. ,476 2. .415 1. .00 20. .95 C

ANISOU 2228 C HIS B 104 1810 3203 2945 202 -338 -745 C

ATOM 2229 O HIS B 104 -6.627 18. ,282 1. .799 1. .00 23. .36 O

ANISOU 2229 O HIS B 104 1940 3459 3476 41 -678 -535 O

ATOM 2230 CB HIS B 104 -4.804 16. ,336 3. .303 1. .00 21. .00 C

ANISOU 2230 CB HIS B 104 1941 3161 2877 195 -410 -452 C

ATOM 2231 CG HIS B 104 -4.370 15. ,518 4. .478 1. .00 21. .63 c

ANISOU 2231 CG HIS B 104 1982 3458 2777 -73 -440 -220 c

ATOM 2232 ND1 HIS B 104 -3.125 15. ,599 4. .999 1. .00 20. .74 N

ANISOU 2232 ND1 HIS B 104 1985 3315 2577 269 -467 -607 N

ATOM 2233 CD2 HIS B 104 -5.065 14. ,596 5. .250 1. .00 23. .75 C

ANISOU 2233 CD2 HIS B 104 2223 3960 2842 -486 -211 -266 C

ATOM 2234 CE1 HIS B 104 -3.031 14. ,764 6. .046 1. .00 18. .14 C

ANISOU 2234 CE1 HIS B 104 1793 3077 2020 223 -446 -905 C

ATOM 2235 NE2 HIS B 104 -4.219 14. ,153 6. .202 1. .00 27. .33 N

ANISOU 2235 NE2 HIS B 104 2782 4494 3107 -743 -626 -47 N

ATOM 2236 N VAL B 105 -4.629 19. ,318 2. .007 1. .00 16. .92 N

ANISOU 2236 N VAL B 105 1187 2945 2293 671 -90 -949 N

ATOM 2237 CA VAL B 105 -4.708 20. ,084 0. .766 1. .00 19. .73 C

ANISOU 2237 CA VAL B 105 1911 3080 2505 678 308 -810 C

ATOM 2238 C VAL B 105 -3.431 19. ,854 -0. .035 1. .00 17. .55 C

ANISOU 2238 C VAL B 105 1742 2957 1966 473 101 -627 C

ATOM 2239 O VAL B 105 -2.338 20. ,153 0. .442 1. .00 19. .90 O

ANISOU 2239 O VAL B 105 1858 3184 2519 688 -251 -865 O

ATOM 2240 CB VAL B 105 -4.884 21. ,602 1. .035 1. .00 21. .32 C

ANISOU 2240 CB VAL B 105 2568 3076 2453 1000 673 -694 C

ATOM 2241 CGI VAL B 105 -4.928 22. ,399 -0. .276 1. .00 22. .15 C

ANISOU 2241 CGI VAL B 105 2295 3320 2799 684 249 -454 C

ATOM 2242 CG2 VAL B 105 -6.138 21. ,855 1. .885 1. .00 22. .27 C

ANISOU 2242 CG2 VAL B 105 2497 3208 2754 930 636 - 1165 C ATOM 2243 N TRP B 106 -3.570 19.,311 -1..239 1..00 20..34 N

ANISOU 2243 N TRP B 106 1916 3653 2158 224 71 -937 N

ATOM 2244 CA TRP B 106 -2.430 19. ,139 -2. .163 1. .00 19. .38 C

ANISOU 2244 CA TRP B 106 1892 3052 2419 406 157 -686 C

ATOM 2245 C TRP B 106 -1.900 20. ,442 -2. .677 1. .00 18. .78 C

ANISOU 2245 C TRP B 106 1879 3032 2223 642 -189 -255 C

ATOM 2246 O TRP B 106 -2.645 21. ,243 -3. .257 1. .00 18. .37 O

ANISOU 2246 O TRP B 106 1747 2709 2523 356 -342 -186 O

ATOM 2247 CB TRP B 106 -2.814 18. ,249 -3. .335 1. .00 20. .21 C

ANISOU 2247 CB TRP B 106 2528 2492 2657 660 -82 -716 C

ATOM 2248 CG TRP B 106 -3.141 16. ,854 -2. .890 1. .00 19. .45 C

ANISOU 2248 CG TRP B 106 2139 2762 2489 378 -773 -532 C

ATOM 2249 CD1 TRP B 106 -4.397 16. ,255 -2. .772 1. .00 21. .36 C

ANISOU 2249 CD1 TRP B 106 1778 2571 3764 709 -862 -649 C

ATOM 2250 CD2 TRP B 106 -2.186 15. ,850 -2. .452 1. .00 18. .71 C

ANISOU 2250 CD2 TRP B 106 1622 2657 2829 464 -470 -910 C

ATOM 2251 NE1 TRP B 106 -4.275 14. ,965 -2. .308 1. .00 22. .48 N

ANISOU 2251 NE1 TRP B 106 1706 2469 4365 99 -951 -556 N

ATOM 2252 CE2 TRP B 106 -2.966 14. ,666 -2. .083 1. .00 20. .97 C

ANISOU 2252 CE2 TRP B 106 1586 2786 3593 143 -794 - 1022 C

ATOM 2253 CE3 TRP B 106 -0.789 15. ,820 -2. .311 1. .00 15. .96 C

ANISOU 2253 CE3 TRP B 106 1473 2614 1976 470 -68 -869 C

ATOM 2254 CZ2 TRP B 106 -2.360 13. ,505 -1. .611 1. .00 20. .68 C

ANISOU 2254 CZ2 TRP B 106 1069 3053 3734 -53 -960 -711 C

ATOM 2255 CZ3 TRP B 106 -0.198 14. ,656 -1. .831 1. .00 16. .76 C

ANISOU 2255 CZ3 TRP B 106 1880 2269 2216 279 -44 -926 C

ATOM 2256 CH2 TRP B 106 -0.958 13. ,520 -1. .499 1. .00 18. .28 c

ANISOU 2256 CH2 TRP B 106 1039 3015 2892 -279 -668 -843 c

ATOM 2257 N PHE B 107 -0.595 20. ,649 -2. .473 1. .00 17. .90 N

ANISOU 2257 N PHE B 107 1906 2795 2100 667 -319 -335 N

ATOM 2258 CA PHE B 107 0.114 21. .834 -2. .951 1. .00 19. .14 C

ANISOU 2258 CA PHE B 107 1818 2806 2647 755 -357 -316 C

ATOM 2259 C PHE B 107 -0.037 22. ,000 -4. .464 1. .00 19. .34 C

ANISOU 2259 C PHE B 107 2186 2528 2635 1000 -147 -326 C

ATOM 2260 O PHE B 107 -0.529 23. ,033 -4. .949 1. .00 19. .92 O

ANISOU 2260 O PHE B 107 2472 2434 2663 1051 -269 -511 O

ATOM 2261 CB PHE B 107 1.592 21. .751 -2. .534 1. .00 17. .68 C

ANISOU 2261 CB PHE B 107 1622 2275 2818 297 -110 -309 c

ATOM 2262 CG PHE B 107 2.468 22. .793 -3. .173 1. .00 17. .05 c

ANISOU 2262 CG PHE B 107 1582 2358 2535 311 -135 -296 c

ATOM 2263 CD1 PHE B 107 2.398 24. .123 -2. .771 1. .00 16. .96 c

ANISOU 2263 CD1 PHE B 107 1576 2381 2484 -152 -803 -376 c

ATOM 2264 CD2 PHE B 107 3.356 22. .443 -4. .190 1. .00 17. .50 c

ANISOU 2264 CD2 PHE B 107 1609 2776 2263 566 -303 -22 c

ATOM 2265 CE1 PHE B 107 3.207 25. ,095 -3. .352 1. .00 18. .49 c

ANISOU 2265 CE1 PHE B 107 2487 2030 2508 92 -70 -465 c

ATOM 2266 CE2 PHE B 107 4.174 23. .410 -4. .779 1. .00 18. .63 c

ANISOU 2266 CE2 PHE B 107 2365 2118 2593 200 -571 -170 c

ATOM 2267 CZ PHE B 107 4.099 24. .746 -4. .357 1. .00 18. .22 c

ANISOU 2267 CZ PHE B 107 2102 2414 2407 454 -374 -624 c

ATOM 2268 N GLY B 108 0.358 20. .968 -5. .206 1. .00 19. .20 N

ANISOU 2268 N GLY B 108 1668 3049 2578 920 -185 -631 N

ATOM 2269 CA GLY B 108 0.359 21. .024 -6. .662 1. .00 20. .94 C

ANISOU 2269 CA GLY B 108 2424 3042 2487 1043 -895 -356 c

ATOM 2270 C GLY B 108 -1.038 21. ,134 -7. .235 1. .00 20. .04 c

ANISOU 2270 C GLY B 108 2157 2888 2569 1186 -481 -202 c

ATOM 2271 O GLY B 108 -1.287 21. ,926 -8. .138 1. .00 26. .86 0

ANISOU 2271 O GLY B 108 3964 3738 2500 665 -1151 207 0

ATOM 2272 N GLU B 109 -1.964 20. ,354 -6. .693 1. .00 21. .63 N

ANISOU 2272 N GLU B 109 2017 3407 2793 951 -479 -482 N

ATOM 2273 CA GLU B 109 -3.302 20. ,260 -7. .269 1. .00 26. .51 C ANISOU 2273 CA GLU B 109 2029 4523 3517 722 -689 -42 C

ATOM 2274 C GLU B 109 -4.205 21. .461 -6. .929 1. .00 23. .36 C

ANISOU 2274 C GLU B 109 1604 5236 2032 999 -1160 111 C

ATOM 2275 O GLU B 109 -5.042 21. .866 -7. .747 1. .00 27. .47 O

ANISOU 2275 O GLU B 109 1851 6561 2026 1470 -1493 -5 O

ATOM 2276 CB GLU B 109 -3.941 18. .943 -6. .827 1. .00 26. .19 C

ANISOU 2276 CB GLU B 109 2554 4260 3134 410 -902 -428 C

ATOM 2277 CG GLU B 109 -5.260 18. .601 -7. .497 1. .00 37. .25 C

ANISOU 2277 CG GLU B 109 2887 6685 4578 -368 -1192 -449 C

ATOM 2278 CD GLU B 109 -5.659 17. .165 -7. .231 1. .00 56. .05 C

ANISOU 2278 CD GLU B 109 6663 8024 6608 -2455 -207 496 C

ATOM 2279 OE1 GLU B 109 -6.159 16. .872 -6. .118 1. .00 62. .50 O

ANISOU 2279 OE1 GLU B 109 5510 10847 7388 -2544 -59 1260 O

ATOM 2280 OE2 GLU B 109 -5.476 16. .325 -8. .142 1. .00 70. .41 O

ANISOU 2280 OE2 GLU B 109 10144 9806 6800 -1000 809 174 O

ATOM 2281 N SER B 110 -4.018 22. .047 -5. .746 1. .00 27. .48 N

ANISOU 2281 N SER B 110 3195 4408 2839 205 -745 -660 N

ATOM 2282 CA SER B 110 -5.013 22. .982 -5. .206 1. .00 26. .32 C

ANISOU 2282 CA SER B 110 3001 4020 2977 325 -739 -114 C

ATOM 2283 C SER B 110 -4.548 24. .393 -4. .848 1. .00 25. .91 C

ANISOU 2283 C SER B 110 2904 3503 3435 691 -827 94 C

ATOM 2284 O SER B 110 -5.364 25. .300 -4. .772 1. .00 28. .83 O

ANISOU 2284 O SER B 110 3230 4178 3546 1297 -1194 -5 O

ATOM 2285 CB SER B 110 -5.690 22. .376 -3. .970 1. .00 26. .62 C

ANISOU 2285 CB SER B 110 3153 3603 3355 321 -154 -210 C

ATOM 2286 OG SER B 110 -6.186 21. .089 -4. .254 1. .00 27. .99 0

ANISOU 2286 OG SER B 110 2364 4058 4212 76 -393 -281 0

ATOM 2287 N MET B 111 -3.258 24. .580 -4. .594 1. .00 24. .07 N

ANISOU 2287 N MET B 111 3276 2910 2960 316 -1049 -288 N

ATOM 2288 CA MET B 111 -2.813 25. .849 -4. .009 1. .00 19. .55 C

ANISOU 2288 CA MET B 111 1902 2980 2544 484 -762 -315 C

ATOM 2289 C MET B 111 -2.427 26. .844 -5. .089 1. .00 22. .89 C

ANISOU 2289 C MET B 111 3138 2798 2759 1018 -285 -262 C

ATOM 2290 O MET B 111 -1.929 26. .445 -6. .148 1. .00 21. .30 O

ANISOU 2290 O MET B 111 2609 2893 2591 1222 -296 -142 O

ATOM 2291 CB MET B 111 -1.661 25. .616 -3. .034 1. .00 20. .34 C

ANISOU 2291 CB MET B 111 1900 3196 2633 1095 -615 22 c

ATOM 2292 CG MET B 111 -2.039 24. .741 -1. .849 1. .00 20. .04 c

ANISOU 2292 CG MET B 111 1632 3320 2660 981 -399 -180 c

ATOM 2293 SD MET B 111 -0.801 24. .744 -0. .540 1. .00 19. .77 s

ANISOU 2293 SD MET B 111 2136 3101 2272 795 -405 -252 s

ATOM 2294 CE MET B 111 -1.385 23. .345 0. .407 1. .00 17. .59 c

ANISOU 2294 CE MET B 111 2051 2530 2103 996 -762 -345 c

ATOM 2295 N ASP B 112 -2.684 28. .129 -4. .829 1. .00 24. .17 N

ANISOU 2295 N ASP B 112 3055 3003 3124 1155 -188 -532 N

ATOM 2296 CA ASP B 112 -2.318 29. .196 -5. .758 1. .00 26. .09 C

ANISOU 2296 CA ASP B 112 3286 2879 3749 956 -320 -309 C

ATOM 2297 C ASP B 112 -0.815 29. .218 -5. .948 1. .00 24. .08 C

ANISOU 2297 C ASP B 112 3240 3009 2900 1206 -341 -371 C

ATOM 2298 O ASP B 112 -0.060 29. .339 -4. .983 1. .00 26. .84 0

ANISOU 2298 O ASP B 112 3157 3548 3491 770 -673 -564 0

ATOM 2299 CB ASP B 112 -2.800 30. .554 -5. .248 1. .00 26. .25 c

ANISOU 2299 CB ASP B 112 2926 3291 3757 1382 -556 -550 c

ATOM 2300 CG ASP B 112 -4.301 30. .700 -5. .321 1. .00 33. .31 c

ANISOU 2300 CG ASP B 112 3063 4677 4914 1408 -759 - 1306 c

ATOM 2301 OD1 ASP B 112 -4.934 29. .886 -6. .023 1. .00 34. .54 0

ANISOU 2301 OD1 ASP B 112 2321 4509 6294 227 -105 -936 0

ATOM 2302 OD2 ASP B 112 -4.854 31. .628 -4. .685 1. .00 34. .15 0

ANISOU 2302 OD2 ASP B 112 2823 5278 4874 2056 238 -550 0

ATOM 2303 N GLY B 113 -0.376 29. .084 -7. .193 1. .00 26. .06 N

ANISOU 2303 N GLY B 113 3296 3848 2757 676 -509 -541 N ATOM 2304 CA GLY B 113 1.060 29..031 -7..469 1..00 23..13 C

ANISOU 2304 CA GLY B 113 3207 2413 3166 1131 -615 126 C

ATOM 2305 C GLY B 113 1.696 27. ,672 -7. .217 1. .00 21. .99 C

ANISOU 2305 C GLY B 113 3197 2158 2999 749 -1000 149 C

ATOM 2306 O GLY B 113 2.914 27. .526 -7. .332 1. .00 24. .15 O

ANISOU 2306 O GLY B 113 3240 2658 3275 297 -344 148 O

ATOM 2307 N GLY B 114 0.877 26. .677 -6. .877 1. .00 23. .14 N

ANISOU 2307 N GLY B 114 3514 2456 2820 714 -355 272 N

ATOM 2308 CA GLY B 114 1.366 25. .320 -6. .637 1. .00 22. .20 C

ANISOU 2308 CA GLY B 114 3362 2612 2458 1024 -493 -151 C

ATOM 2309 C GLY B 114 1.801 24. .630 -7. .918 1. .00 22. .22 C

ANISOU 2309 C GLY B 114 3736 2174 2533 861 -372 -88 C

ATOM 2310 O GLY B 114 1.419 25. .037 -9. .027 1. .00 20. .96 O

ANISOU 2310 O GLY B 114 2867 2355 2742 1016 -687 -318 O

ATOM 2311 N PHE B 115 2.624 23. .599 -7. .771 1. .00 21. .78 N

ANISOU 2311 N PHE B 115 3185 2461 2628 925 -196 -653 N

ATOM 2312 CA PHE B 115 3.076 22. .788 -8. .907 1. .00 20. .56 C

ANISOU 2312 CA PHE B 115 2892 2621 2298 716 -92 -461 C

ATOM 2313 C PHE B 115 3.396 21. .397 -8. .414 1. .00 19. .94 C

ANISOU 2313 C PHE B 115 2529 2691 2353 859 -63 -429 C

ATOM 2314 O PHE B 115 3.700 21. .200 -7. .231 1. .00 22. .95 O

ANISOU 2314 O PHE B 115 2610 3408 2701 877 -686 -536 O

ATOM 2315 CB PHE B 115 4.316 23. .399 -9. .588 1. .00 23. .53 C

ANISOU 2315 CB PHE B 115 3317 2849 2772 202 -28 -362 C

ATOM 2316 CG PHE B 115 5.438 23. .740 -8. .633 1. .00 24. .54 c

ANISOU 2316 CG PHE B 115 3078 3449 2794 253 -72 -139 c

ATOM 2317 CD1 PHE B 115 5.485 24. .987 -8. .006 1. .00 23. .52 c

ANISOU 2317 CD1 PHE B 115 3320 3386 2228 425 -299 -120 c

ATOM 2318 CD2 PHE B 115 6.453 22. .823 -8. .366 1. .00 26. .00 c

ANISOU 2318 CD2 PHE B 115 3380 3544 2954 252 -44 152 c

ATOM 2319 CE1 PHE B 115 6.521 25. .306 -7. .119 1. .00 21. .57 c

ANISOU 2319 CE1 PHE B 115 2094 2682 3418 621 -69 -126 c

ATOM 2320 CE2 PHE B 115 7.491 23. .136 -7. .488 1. .00 24. .82 c

ANISOU 2320 CE2 PHE B 115 3128 2920 3381 48 18 -88 c

ATOM 2321 CZ PHE B 115 7.522 24. .376 -6. .855 1. .00 20. .90 c

ANISOU 2321 CZ PHE B 115 2148 2666 3127 468 -366 128 c

ATOM 2322 N GLN B 116 3.329 20. ,435 -9. .325 1. .00 20. .42 N

ANISOU 2322 N GLN B 116 2453 2484 2819 510 -99 -495 N

ATOM 2323 CA GLN B 116 3.794 19. .088 -9. .045 1. .00 20. .02 C

ANISOU 2323 CA GLN B 116 2199 2501 2905 328 -317 -50 C

ATOM 2324 C GLN B 116 5.298 18. .988 -9. .314 1. .00 19. .40 c

ANISOU 2324 C GLN B 116 2215 2656 2500 498 -667 -206 c

ATOM 2325 O GLN B 116 5.863 19. .755 -10. .114 1. .00 23. .42 0

ANISOU 2325 O GLN B 116 2756 3018 3124 642 -623 251 0

ATOM 2326 CB GLN B 116 2.960 18. .052 -9. .820 1. .00 23. .13 c

ANISOU 2326 CB GLN B 116 2984 2789 3014 285 -292 -450 c

ATOM 2327 CG GLN B 116 1.478 18. .186 -9. .458 1. .00 29. .91 c

ANISOU 2327 CG GLN B 116 3016 4327 4021 68 -183 -632 c

ATOM 2328 CD GLN B 116 0.706 16. .891 -9. .500 1. .00 31. .43 c

ANISOU 2328 CD GLN B 116 4580 3502 3860 564 -1255 - 1193 c

ATOM 2329 OE1 GLN B 116 0.884 16. .078 -10. .404 1. .00 33. .70 0

ANISOU 2329 OE1 GLN B 116 5312 4506 2986 -334 -1530 - 1493 0

ATOM 2330 NE2 GLN B 116 -0.185 16. ,699 -8. .519 1. .00 35. .37 N

ANISOU 2330 NE2 GLN B 116 4073 5387 3979 229 -1808 - 1591 N

ATOM 2331 N PHE B 117 5.950 18. .069 -8. .617 1. .00 17. .41 N

ANISOU 2331 N PHE B 117 1692 2817 2106 800 -432 -475 N

ATOM 2332 CA PHE B 117 7.399 17. .986 -8. .661 1. .00 17. .99 C

ANISOU 2332 CA PHE B 117 1633 3138 2061 327 -592 -474 C

ATOM 2333 C PHE B 117 7.916 17. ,313 -9. .935 1. .00 16. .99 C

ANISOU 2333 C PHE B 117 1794 2752 1906 352 -789 -351 C

ATOM 2334 O PHE B 117 7.416 16. .281 -10. .350 1. .00 18. .74 O ANISOU 2334 O PHE B 117 1778 3243 2100 -44 -441 -721 O

ATOM 2335 CB PHE B 117 7.939 17. .303 -7. .388 1. .00 18. .11 C

ANISOU 2335 CB PHE B 117 1996 2998 1885 256 - 341 -350 C

ATOM 2336 CG PHE B 117 7.403 17. .894 -6. .101 1. .00 19. .22 C

ANISOU 2336 CG PHE B 117 2365 3103 1835 267 - 360 -364 C

ATOM 2337 CD1 PHE B 117 7.254 19. .282 -5. .951 1. .00 20. .01 C

ANISOU 2337 CD1 PHE B 117 2562 3195 1844 418 - 527 -802 C

ATOM 2338 CD2 PHE B 117 7.067 17. .066 -5. .020 1. .00 16. .68 C

ANISOU 2338 CD2 PHE B 117 2016 2360 1961 58 - 309 -524 C

ATOM 2339 CE1 PHE B 117 6.761 19. .833 -4. .763 1. .00 20. .55 C

ANISOU 2339 CE1 PHE B 117 2847 3531 1427 601 - 510 -350 C

ATOM 2340 CE2 PHE B 117 6.580 17. .613 -3. .832 1. .00 17. .52 C

ANISOU 2340 CE2 PHE B 117 2016 2602 2037 361 - 696 -837 C

ATOM 2341 CZ PHE B 117 6.424 18. .997 -3. .701 1. .00 16. .90 C

ANISOU 2341 CZ PHE B 117 2119 2509 1791 58 - 395 -670 C

ATOM 2342 N SER B 118 8.932 17. .906 -10. .551 1. .00 19. .56 N

ANISOU 2342 N SER B 118 2492 2807 2130 564 -92 -197 N

ATOM 2343 CA SER B 118 9.516 17. .325 -11. .749 1. .00 20. .55 C

ANISOU 2343 CA SER B 118 2566 3318 1923 532 79 -95 C

ATOM 2344 C SER B 118 10.999 17. .082 -11. .520 1. .00 20. .97 C

ANISOU 2344 C SER B 118 2530 3103 2332 222 - 107 -263 C

ATOM 2345 O SER B 118 11.600 17. ,667 -10. .605 1. .00 17. .66 O

ANISOU 2345 O SER B 118 1568 2905 2236 121 41 96 O

ATOM 2346 CB SER B 118 9.262 18. .197 -12. .984 1. .00 27. .06 C

ANISOU 2346 CB SER B 118 3841 3496 2943 848 - 277 531 C

ATOM 2347 OG SER B 118 9.538 19. .543 -12. .697 1. .00 35. .45 0

ANISOU 2347 OG SER B 118 5566 3704 4198 506 - 119 1756 0

ATOM 2348 N TYR B 119 11.568 16. .198 -12. .341 1. .00 20. .54 N

ANISOU 2348 N TYR B 119 2398 3155 2249 -51 276 -211 N

ATOM 2349 CA TYR B 119 12.917 15. .674 -12. .144 1. .00 19. .45 C

ANISOU 2349 CA TYR B 119 2290 2779 2321 -129 386 -34 C

ATOM 2350 C TYR B 119 13.733 15. .676 -13. .438 1. .00 21. .84 C

ANISOU 2350 C TYR B 119 2110 3658 2528 -353 483 -216 C

ATOM 2351 O TYR B 119 13.224 15. .375 -14. .518 1. .00 24. .92 O

ANISOU 2351 O TYR B 119 1913 4438 3116 -638 60 -69 O

ATOM 2352 CB TYR B 119 12.845 14. .260 -11. .542 1. .00 17. .15 C

ANISOU 2352 CB TYR B 119 1889 2914 1713 0 -69 6 c

ATOM 2353 CG TYR B 119 12.135 14. .285 -10. .212 1. .00 17. .02 c

ANISOU 2353 CG TYR B 119 1600 3016 1852 212 -33 -282 c

ATOM 2354 CD1 TYR B 119 10.735 14. .258 -10. .140 1. .00 15. .55 c

ANISOU 2354 CD1 TYR B 119 1545 2346 2017 558 - 131 35 c

ATOM 2355 CD2 TYR B 119 12.861 14. .401 -9. .017 1. .00 15. .32 c

ANISOU 2355 CD2 TYR B 119 1797 2255 1769 360 - 102 -341 c

ATOM 2356 CE1 TYR B 119 10.083 14. .332 -8. .919 1. .00 15. .50 c

ANISOU 2356 CE1 TYR B 119 1816 2146 1926 413 -95 -155 c

ATOM 2357 CE2 TYR B 119 12.218 14. .457 -7. .792 1. .00 14. .76 c

ANISOU 2357 CE2 TYR B 119 1426 2022 2161 130 112 -260 c

ATOM 2358 CZ TYR B 119 10.833 14. .427 -7. .748 1. .00 14. .14 c

ANISOU 2358 CZ TYR B 119 1430 2007 1934 71 73 -199 c

ATOM 2359 OH TYR B 119 10.226 14. ,500 -6. .526 1. .00 14. .11 0

ANISOU 2359 OH TYR B 119 1355 2172 1834 161 -50 -502 0

ATOM 2360 N GLY B 120 15.007 16. .022 -13. .322 1. .00 21. .61 N

ANISOU 2360 N GLY B 120 2363 3254 2592 -814 603 127 N

ATOM 2361 CA GLY B 120 15.909 15. .929 -14. .452 1. .00 22. .54 C

ANISOU 2361 CA GLY B 120 2122 3912 2530 -603 480 423 c

ATOM 2362 C GLY B 120 16.169 17. .243 -15. .158 1. .00 27. .01 c

ANISOU 2362 C GLY B 120 3094 3756 3412 -814 -93 551 c

ATOM 2363 O GLY B 120 15.498 18. .255 -14. .908 1. .00 28. .33 0

ANISOU 2363 O GLY B 120 3464 4349 2951 -688 329 631 0

ATOM 2364 N ASN B 121 17.160 17. .187 -16. .044 1. .00 31. .76 N

ANISOU 2364 N ASN B 121 2822 5548 3694 -669 - 136 841 N ATOM 2365 CA ASN B 121 17.631 18..294 -16..862 1..00 39..43 C

ANISOU 2365 CA ASN B 121 4944 5014 5022 -513 -121 1061 C

ATOM 2366 C ASN B 121 16.454 18. .942 -17. .616 1. .00 34. .57 C

ANISOU 2366 C ASN B 121 4358 4480 4295 -1101 -286 173 C

ATOM 2367 O ASN B 121 15.960 18. .352 -18. .577 1. .00 33. .72 O

ANISOU 2367 O ASN B 121 4822 4203 3787 -1230 -315 374 O

ATOM 2368 CB ASN B 121 18.694 17. .785 -17. .886 1. .00 46. .31 C

ANISOU 2368 CB ASN B 121 3950 6973 6671 -263 131 924 C

ATOM 2369 CG ASN B 121 19.477 16. .532 -17. .421 1. .00 47. .97 C

ANISOU 2369 CG ASN B 121 4802 6657 6767 -170 881 1147 C

ATOM 2370 OD1 ASN B 121 18.982 15. .702 -16. .640 1. .00 41. .25 O

ANISOU 2370 OD1 ASN B 121 6378 3515 5780 -79 -1580 1056 O

ATOM 2371 ND2 ASN B 121 20.706 16. .379 -17. .942 1. .00 32. .59 N

ANISOU 2371 ND2 ASN B 121 3445 4983 3954 -443 -921 -253 N

ATOM 2372 N PRO B 122 15.995 20. .149 -17. .194 1. .00 34. .08 N

ANISOU 2372 N PRO B 122 4791 4055 4101 -1933 698 -210 N

ATOM 2373 CA PRO B 122 14.871 20. .779 -17. .912 1. .00 41. .38 C

ANISOU 2373 CA PRO B 122 6541 4269 4909 -652 252 -278 C

ATOM 2374 C PRO B 122 15.216 21. .220 -19. .342 1. .00 39. .07 C

ANISOU 2374 C PRO B 122 5464 4736 4644 -625 -177 -338 C

ATOM 2375 O PRO B 122 14.352 21. .699 -20. .069 1. .00 40. .48 O

ANISOU 2375 O PRO B 122 5190 4591 5599 -1035 -310 456 O

ATOM 2376 CB PRO B 122 14.519 21. ,994 -17. .037 1. .00 43. .47 C

ANISOU 2376 CB PRO B 122 7049 5562 3905 -957 804 -851 C

ATOM 2377 CG PRO B 122 15.761 22. .286 -16. .274 1. .00 45. .02 C

ANISOU 2377 CG PRO B 122 6953 4729 5424 -1574 704 - 1027 C

ATOM 2378 CD PRO B 122 16.397 20. .944 -16. .019 1. .00 42. .77 C

ANISOU 2378 CD PRO B 122 6392 4996 4862 -1866 96 -688 C

ATOM 2379 N GLU B 123 16.476 21. .061 -19. .730 1. .00 39. .91 N

ANISOU 2379 N GLU B 123 5325 4902 4934 -1379 -243 -356 N

ATOM 2380 CA GLU B 123 16.881 21. .245 -21. .118 1. .00 43. .07 C

ANISOU 2380 CA GLU B 123 6346 5662 4355 -1113 -1188 -605 C

ATOM 2381 C GLU B 123 16.288 20. .138 -22. .012 1. .00 34. .80 C

ANISOU 2381 C GLU B 123 4977 4417 3826 -993 -1263 577 C

ATOM 2382 O GLU B 123 16.031 20. .365 -23. .190 1. .00 45. .07 O

ANISOU 2382 O GLU B 123 7045 5843 4234 -779 -1766 1245 O

ATOM 2383 CB GLU B 123 18.416 21. .326 -21. .243 1. .00 51. .93 C

ANISOU 2383 CB GLU B 123 6691 7020 6020 -1706 -1045 67 C

ATOM 2384 CG GLU B 123 19.208 20. .298 -20. .428 1. .00 57. .97 c

ANISOU 2384 CG GLU B 123 6655 7506 7864 -672 -2119 -846 c

ATOM 2385 CD GLU B 123 19.465 20. .703 -18. .972 1. .00 58. .06 c

ANISOU 2385 CD GLU B 123 6532 7687 7839 158 -1694 -870 c

ATOM 2386 OE1 GLU B 123 18.532 21. .173 -18. .276 1. .00 46. .71 0

ANISOU 2386 OE1 GLU B 123 5545 6725 5479 -1545 -1714 -723 0

ATOM 2387 OE2 GLU B 123 20.612 20. ,520 -18. .501 1. .00 66. .25 0

ANISOU 2387 OE2 GLU B 123 7137 7667 10367 914 -2688 -224 0

ATOM 2388 N LEU B 124 16.062 18. .953 -21. .445 1. .00 24. .05 N

ANISOU 2388 N LEU B 124 3133 3259 2744 -42 -943 -582 N

ATOM 2389 CA LEU B 124 15.430 17. .856 -22. .172 1. .00 21. .51 C

ANISOU 2389 CA LEU B 124 2090 2609 3472 -207 -538 -69 C

ATOM 2390 C LEU B 124 13.901 17. .961 -22. .156 1. .00 21. .19 C

ANISOU 2390 C LEU B 124 2172 3000 2877 51 -494 -393 C

ATOM 2391 O LEU B 124 13.322 18. .390 -21. .149 1. .00 23. .61 0

ANISOU 2391 O LEU B 124 3232 2606 3130 208 56 -388 0

ATOM 2392 CB LEU B 124 15.868 16. .500 -21. .600 1. .00 22. .48 c

ANISOU 2392 CB LEU B 124 1337 3274 3928 235 -603 414 c

ATOM 2393 CG LEU B 124 17.278 16. ,053 -21. .989 1. .00 26. .30 c

ANISOU 2393 CG LEU B 124 2143 3657 4191 1028 -33 419 c

ATOM 2394 CD1 LEU B 124 17.726 14. .856 -21. .166 1. .00 32. .52 c

ANISOU 2394 CD1 LEU B 124 3950 3579 4825 710 -354 726 c

ATOM 2395 CD2 LEU B 124 17.350 15. .725 -23. .472 1. .00 32. .93 c ANISOU 2395 CD2 LEU B 124 3582 4761 4168 236 -853 -28 C

ATOM 2396 N PRO B 125 13.243 17. .566 -23. .269 1. .00 21. .42 N

ANISOU 2396 N PRO B 125 2431 2888 2818 -231 -728 65 N

ATOM 2397 CA PRO B 125 11.774 17. .569 -23. .336 1. .00 21. .50 C

ANISOU 2397 CA PRO B 125 2487 2833 2849 -471 -742 -27 C

ATOM 2398 C PRO B 125 11.166 16. .768 -22. .188 1. .00 20. .27 C

ANISOU 2398 C PRO B 125 2601 2667 2433 131 -394 -212 C

ATOM 2399 O PRO B 125 11.713 15. ,729 -21. .806 1. .00 20. .24 O

ANISOU 2399 O PRO B 125 2543 2602 2543 225 -545 -288 O

ATOM 2400 CB PRO B 125 11.494 16. .869 -24. .666 1. .00 21. .42 C

ANISOU 2400 CB PRO B 125 2569 3031 2535 -429 -893 154 C

ATOM 2401 CG PRO B 125 12.685 17. .196 -25. .496 1. .00 22. .93 C

ANISOU 2401 CG PRO B 125 2685 3194 2833 -241 -797 -11 C

ATOM 2402 CD PRO B 125 13.836 17. .108 -24. .536 1. .00 20. .45 c

ANISOU 2402 CD PRO B 125 1928 2697 3145 -283 -499 -6 c

ATOM 2403 N GLU B 126 10.055 17. .257 -21. .646 1. .00 21. .02 N

ANISOU 2403 N GLU B 126 2555 2462 2967 142 -497 -505 N

ATOM 2404 CA GLU B 126 9.334 16. .591 -20. .550 1. .00 20. .25 C

ANISOU 2404 CA GLU B 126 2766 2279 2649 183 -483 -582 C

ATOM 2405 C GLU B 126 9.091 15. .088 -20. .814 1. .00 17. .82 C

ANISOU 2405 C GLU B 126 2358 2178 2234 316 -673 -214 C

ATOM 2406 O GLU B 126 9.236 14. .244 -19. .925 1. .00 18. .77 O

ANISOU 2406 O GLU B 126 2810 2109 2211 742 -552 -258 O

ATOM 2407 CB GLU B 126 7.998 17. .306 -20. .306 1. .00 26. .84 c

ANISOU 2407 CB GLU B 126 3501 2720 3976 850 -70 -747 c

ATOM 2408 CG GLU B 126 7.027 16. .573 -19. .382 1. .00 30. .78 c

ANISOU 2408 CG GLU B 126 3124 3862 4708 849 228 -535 c

ATOM 2409 CD GLU B 126 5.693 17. .288 -19. .204 1. .00 41. .85 c

ANISOU 2409 CD GLU B 126 3701 5489 6709 1674 610 -135 c

ATOM 2410 OE1 GLU B 126 5.584 18. .500 -19. .515 1. .00 43. .36 0

ANISOU 2410 OE1 GLU B 126 4163 5854 6457 1320 3 514 0

ATOM 2411 OE2 GLU B 126 4.743 16. .624 -18. .740 1. .00 47. .98 0

ANISOU 2411 OE2 GLU B 126 4547 5831 7850 963 296 1157 0

ATOM 2412 N ASP B 127 8.715 14. .762 -22. .043 1. .00 16. .62 N

ANISOU 2412 N ASP B 127 1761 2373 2180 192 -360 -497 N

ATOM 2413 CA ASP B 127 8.371 13. ,381 -22. .367 1. .00 17. .84 C

ANISOU 2413 CA ASP B 127 2410 2244 2124 415 -655 -350 C

ATOM 2414 C ASP B 127 9.599 12. .478 -22. .317 1. .00 18. .29 C

ANISOU 2414 C ASP B 127 2001 2437 2509 151 -387 288 c

ATOM 2415 O ASP B 127 9.521 11. .327 -21. .884 1. .00 16. .64 0

ANISOU 2415 O ASP B 127 1461 2463 2396 200 -442 347 0

ATOM 2416 CB ASP B 127 7.662 13. .297 -23. .726 1. .00 18. .31 c

ANISOU 2416 CB ASP B 127 2245 2387 2322 182 -891 -148 c

ATOM 2417 CG ASP B 127 8.497 13. .852 -24. .865 1. .00 19. .08 c

ANISOU 2417 CG ASP B 127 2102 2316 2829 -188 -1079 163 c

ATOM 2418 OD1 ASP B 127 8.653 15. .088 -24. .933 1. .00 25. .51 0

ANISOU 2418 OD1 ASP B 127 4013 2269 3409 -150 -1348 22 0

ATOM 2419 OD2 ASP B 127 8.974 13. .058 -25. .710 1. .00 24. .24 0

ANISOU 2419 OD2 ASP B 127 3015 2756 3436 -350 -527 -167 0

ATOM 2420 N VAL B 128 10.737 13. .025 -22. .734 1. .00 18. .57 N

ANISOU 2420 N VAL B 128 2054 2662 2340 33 -176 101 N

ATOM 2421 CA VAL B 128 11.994 12. .287 -22. .732 1. .00 19. .17 C

ANISOU 2421 CA VAL B 128 2422 2628 2234 259 -249 -114 C

ATOM 2422 C VAL B 128 12.439 11. .987 -21. .300 1. .00 16. .03 c

ANISOU 2422 C VAL B 128 1898 1835 2356 -2 -440 -257 c

ATOM 2423 O VAL B 128 12.844 10. .856 -20. .981 1. .00 17. .11 0

ANISOU 2423 O VAL B 128 2053 1848 2599 -137 -448 -14 0

ATOM 2424 CB VAL B 128 13.057 13. .049 -23. .545 1. .00 17. .73 c

ANISOU 2424 CB VAL B 128 2527 2480 1730 258 -652 206 c

ATOM 2425 CGI VAL B 128 14.411 12. .368 -23. .453 1. .00 21. .73 c

ANISOU 2425 CGI VAL B 128 2565 2513 3176 411 -284 153 c ATOM 2426 CG2 VAL B 128 12.591 13..155 -24..999 1..00 18..72 C

ANISOU 2426 CG2 VAL B 128 2532 3018 1563 -132 - 421 272 C

ATOM 2427 N LEU B 129 12.320 12. ,991 -20. .428 1. .00 16. .25 N

ANISOU 2427 N LEU B 129 2138 2026 2011 221 - 483 -248 N

ATOM 2428 CA LEU B 129 12.620 12. .798 -19. .016 1. .00 15. .10 C

ANISOU 2428 CA LEU B 129 1980 1713 2043 39 - 441 -244 C

ATOM 2429 C LEU B 129 11.687 11. .763 -18. .411 1. .00 16. .73 C

ANISOU 2429 C LEU B 129 1831 2248 2278 115 - 209 38 C

ATOM 2430 O LEU B 129 12.123 10. .910 -17. .666 1. .00 16. .23 O

ANISOU 2430 O LEU B 129 1708 2284 2174 247 - 553 -191 O

ATOM 2431 CB LEU B 129 12.531 14. .109 -18. .228 1. .00 17. .27 C

ANISOU 2431 CB LEU B 129 2164 1677 2720 173 - 388 -445 C

ATOM 2432 CG LEU B 129 13.575 15. .157 -18. .572 1. .00 20. .60 c

ANISOU 2432 CG LEU B 129 2439 1763 3622 132 - 153 -400 c

ATOM 2433 CD1 LEU B 129 13.322 16. ,433 -17. .796 1. .00 23. .61 c

ANISOU 2433 CD1 LEU B 129 2734 2264 3973 -231 -18 -995 c

ATOM 2434 CD2 LEU B 129 14.990 14. .639 -18. .315 1. .00 24. .52 c

ANISOU 2434 CD2 LEU B 129 2606 2772 3937 359 - 592 - 1267 c

ATOM 2435 N ASP B 130 10.401 11. .823 -18. .750 1. .00 18. .80 N

ANISOU 2435 N ASP B 130 2089 2765 2289 506 - 926 22 N

ATOM 2436 CA ASP B 130 9.455 10. .847 -18. .231 1. .00 22. .50 C

ANISOU 2436 CA ASP B 130 2835 3205 2507 144 - 285 -91 C

ATOM 2437 C ASP B 130 9.848 9. .436 -18. .589 1. .00 21. .34 C

ANISOU 2437 C ASP B 130 1950 3512 2645 120 132 -321 C

ATOM 2438 O ASP B 130 9.669 8. .531 -17. .798 1. .00 21. .69 O

ANISOU 2438 O ASP B 130 2474 2945 2820 98 134 -443 0

ATOM 2439 CB ASP B 130 8.081 11. .056 -18. .830 1. .00 19. .32 c

ANISOU 2439 CB ASP B 130 2538 2427 2374 -161 -91 -123 c

ATOM 2440 CG ASP B 130 7.360 12. .233 -18. .270 1. .00 22. .76 c

ANISOU 2440 CG ASP B 130 2856 2964 2827 126 - 289 -150 c

ATOM 2441 OD1 ASP B 130 7.793 12. .822 -17. .268 1. .00 23. .85 0

ANISOU 2441 OD1 ASP B 130 3058 3219 2784 259 -99 -388 0

ATOM 2442 OD2 ASP B 130 6.325 12. ,573 -18. .877 1. .00 25. .05 0

ANISOU 2442 OD2 ASP B 130 2560 3273 3685 308 -63 2 0

ATOM 2443 N VAL B 131 10.356 9. .258 -19. .805 1. .00 13. .30 N

ANISOU 2443 N VAL B 131 1297 1621 2134 301 - 528 -509 N

ATOM 2444 CA VAL B 131 10.738 7. .920 -20. .291 1. .00 13. .09 C

ANISOU 2444 CA VAL B 131 1339 1576 2058 419 - 398 -303 C

ATOM 2445 C VAL B 131 12.011 7. .436 -19. .600 1. .00 12. .70 C

ANISOU 2445 C VAL B 131 1363 1600 1862 289 - 454 -304 C

ATOM 2446 O VAL B 131 12.104 6. .283 -19. .181 1. .00 12. .41 0

ANISOU 2446 O VAL B 131 1265 1643 1804 -78 - 319 -89 0

ATOM 2447 CB VAL B 131 10.896 7. .878 -21. .827 1. .00 17. .44 c

ANISOU 2447 CB VAL B 131 2082 2460 2084 296 - 304 -300 c

ATOM 2448 CGI VAL B 131 11.556 6. ,570 -22. .281 1. .00 14. .47 c

ANISOU 2448 CGI VAL B 131 1331 2119 2045 -59 - 332 -23 c

ATOM 2449 CG2 VAL B 131 9.514 8. .007 -22. .483 1. .00 17. .35 c

ANISOU 2449 CG2 VAL B 131 2094 2229 2266 18 - 307 272 c

ATOM 2450 N GLN B 132 12.984 8. .315 -19. .460 1. .00 13. .09 N

ANISOU 2450 N GLN B 132 1244 1637 2091 238 - 242 -189 N

ATOM 2451 CA GLN B 132 14.214 7. .924 -18. .736 1. .00 14. .71 C

ANISOU 2451 CA GLN B 132 1528 1962 2099 342 - 437 -20 C

ATOM 2452 C GLN B 132 13.854 7. .482 -17. .313 1. .00 14. .53 C

ANISOU 2452 C GLN B 132 1745 1688 2085 437 - 233 -255 C

ATOM 2453 O GLN B 132 14.300 6. .429 -16. .850 1. .00 13. .33 0

ANISOU 2453 O GLN B 132 1400 1650 2013 275 -81 -163 0

ATOM 2454 CB GLN B 132 15.258 9. ,051 -18. .723 1. .00 15. .84 c

ANISOU 2454 CB GLN B 132 1550 2161 2307 274 - 261 17 c

ATOM 2455 CG GLN B 132 15.846 9. .425 -20. .087 1. .00 17. .26 c

ANISOU 2455 CG GLN B 132 1989 2376 2193 124 - 237 -4 c

ATOM 2456 CD GLN B 132 16.737 8. .351 -20. .687 1. .00 14. .34 c ANISOU 2456 CD GLN B 132 1088 2384 1975 -82 -418 299 C

ATOM 2457 OE1 GLN B 132 16.565 7. .165 -20. .425 1. .00 15. , 15 O

ANISOU 2457 OE1 GLN B 132 1341 2315 2097 -66 - 234 359 O

ATOM 2458 NE2 GLN B 132 17.697 8. .771 -21. .515 1. .00 16. , 87 N

ANISOU 2458 NE2 GLN B 132 1362 2866 2179 288 137 280 N

ATOM 2459 N LEU B 133 13.012 8. .276 -16. .643 1. .00 14. ,79 N

ANISOU 2459 N LEU B 133 1561 2276 1781 475 - 186 -287 N

ATOM 2460 CA LEU B 133 12.490 7. .934 -15. .331 1. .00 15. , 12 C

ANISOU 2460 CA LEU B 133 1979 1914 1851 170 - 144 -286 C

ATOM 2461 C LEU B 133 11.690 6. .651 -15. .354 1. .00 14. ,26 C

ANISOU 2461 C LEU B 133 1853 1874 1689 243 - 230 -303 C

ATOM 2462 O LEU B 133 11.800 5. .856 -14. .431 1. .00 12. , 64 O

ANISOU 2462 O LEU B 133 1626 1773 1401 94 -45 -350 O

ATOM 2463 CB LEU B 133 11.646 9. .087 -14. .730 1. .00 18. ,16 C

ANISOU 2463 CB LEU B 133 2201 2178 2517 375 -4 -476 C

ATOM 2464 CG LEU B 133 12.315 10. .153 -13. .837 1. .00 20. , 91 C

ANISOU 2464 CG LEU B 133 2660 2856 2427 32 - 161 -521 C

ATOM 2465 CD1 LEU B 133 12.841 9. .581 -12. .532 1. .00 20. , 31 C

ANISOU 2465 CD1 LEU B 133 1685 3204 2826 135 - 385 -582 C

ATOM 2466 CD2 LEU B 133 13.430 10. .893 -14. .560 1. .00 25. , 61 C

ANISOU 2466 CD2 LEU B 133 2985 3345 3398 -473 25 -662 C

ATOM 2467 N ALA B 134 10.899 6. .431 -16. .403 1. .00 12. ,76 N

ANISOU 2467 N ALA B 134 1570 1683 1596 119 -4 -391 N

ATOM 2468 CA ALA B 134 10.056 5. ,227 -16. .445 1. .00 12. , 82 C

ANISOU 2468 CA ALA B 134 1480 1591 1799 153 - 160 -387 C

ATOM 2469 C ALA B 134 10.921 3. .963 -16. .490 1. .00 13. , 03 C

ANISOU 2469 C ALA B 134 1613 1556 1778 179 26 -100 C

ATOM 2470 O ALA B 134 10.574 2. .963 -15. .869 1. .00 12. , 07 O

ANISOU 2470 O ALA B 134 1336 1696 1553 243 - 132 133 O

ATOM 2471 CB ALA B 134 9.102 5. .261 -17. .627 1. .00 14. , 63 C

ANISOU 2471 CB ALA B 134 1612 2320 1626 84 - 137 -311 C

ATOM 2472 N PHE B 135 12.045 4. .012 -17. .218 1. .00 13. , 68 N

ANISOU 2472 N PHE B 135 1309 2228 1658 203 - 234 -359 N

ATOM 2473 CA PHE B 135 12.944 2. .861 -17. .266 1. .00 12. , 92 C

ANISOU 2473 CA PHE B 135 1321 2094 1493 159 91 -319 C

ATOM 2474 C PHE B 135 13.484 2. .581 -15. .870 1. .00 13. ,09 C

ANISOU 2474 C PHE B 135 1568 1711 1693 200 -28 -182 C

ATOM 2475 O PHE B 135 13.531 1. .428 -15. .431 1. .00 13. , 02 O

ANISOU 2475 O PHE B 135 1517 1685 1745 402 -30 -144 O

ATOM 2476 CB PHE B 135 14.117 3. .069 -18. .275 1. .00 11. , 84 C

ANISOU 2476 CB PHE B 135 1191 1999 1309 209 -9 -509 C

ATOM 2477 CG PHE B 135 13.798 2. .605 -19. .676 1. .00 12. , 07 c

ANISOU 2477 CG PHE B 135 1390 1951 1245 263 - 200 -262 c

ATOM 2478 CD1 PHE B 135 13.008 3. .385 -20. .511 1. .00 12. , 87 c

ANISOU 2478 CD1 PHE B 135 1517 1998 1372 180 - 315 -126 c

ATOM 2479 CD2 PHE B 135 14.250 1. .374 -20. .140 1. .00 11. , 90 c

ANISOU 2479 CD2 PHE B 135 1228 2080 1212 93 234 -327 c

ATOM 2480 CE1 PHE B 135 12.702 2. .962 -21. .800 1. .00 12. , 24 c

ANISOU 2480 CE1 PHE B 135 1379 1806 1463 241 -97 -407 c

ATOM 2481 CE2 PHE B 135 13.944 0. .941 -21. .417 1. .00 11. ,11 c

ANISOU 2481 CE2 PHE B 135 1260 1636 1325 256 - 156 -203 c

ATOM 2482 CZ PHE B 135 13.167 1. .743 -22. .256 1. .00 10. , 57 c

ANISOU 2482 CZ PHE B 135 1215 1490 1310 180 -95 -95 c

ATOM 2483 N LEU B 136 13.880 3. .637 -15. .169 1. .00 12. , 73 N

ANISOU 2483 N LEU B 136 1072 2203 1561 216 - 123 -447 N

ATOM 2484 CA LEU B 136 14.437 3. .465 -13. .833 1. .00 13. , 13 C

ANISOU 2484 CA LEU B 136 1403 1961 1623 200 - 211 -441 C

ATOM 2485 C LEU B 136 13.370 2. ,959 -12. .861 1. .00 12. , 62 c

ANISOU 2485 C LEU B 136 1538 1692 1563 246 - 181 -434 c

ATOM 2486 O LEU B 136 13.628 2. .078 -12. .015 1. .00 14. , 13 0

ANISOU 2486 O LEU B 136 1676 1995 1697 -87 -8 -93 0 ATOM 2487 CB LEU B 136 15.053 4..786 -13..361 1..00 14..53 C

ANISOU 2487 CB LEU B 136 1105 2327 2086 -265 -55 -435 C

ATOM 2488 CG LEU B 136 16.328 5. .181 -14. .128 1. .00 15. .36 C

ANISOU 2488 CG LEU B 136 1149 2464 2222 -48 -14 -123 C

ATOM 2489 CD1 LEU B 136 16.725 6. .600 -13. .750 1. .00 17. .23 C

ANISOU 2489 CD1 LEU B 136 1553 2729 2262 -538 181 -175 C

ATOM 2490 CD2 LEU B 136 17.467 4. .206 -13. .838 1. .00 18. .61 C

ANISOU 2490 CD2 LEU B 136 1641 2657 2771 364 - 312 -667 C

ATOM 2491 N ARG B 137 12.157 3. .475 -13. .016 1. .00 13. .76 N

ANISOU 2491 N ARG B 137 1384 2138 1704 180 - 147 -325 N

ATOM 2492 CA ARG B 137 11.055 3. .146 -12. .097 1. .00 14. .04 C

ANISOU 2492 CA ARG B 137 1613 1891 1828 347 54 -310 C

ATOM 2493 C ARG B 137 10.591 1. .696 -12. .267 1. .00 14. .48 C

ANISOU 2493 C ARG B 137 1508 2000 1994 239 - 237 -138 C

ATOM 2494 O ARG B 137 10.420 0. .969 -11. .280 1. .00 15. .45 O

ANISOU 2494 O ARG B 137 1473 2396 1999 -76 -8 -111 O

ATOM 2495 CB ARG B 137 9.894 4. .133 -12. .294 1. .00 14. .05 C

ANISOU 2495 CB ARG B 137 1623 1678 2037 308 0 -441 C

ATOM 2496 CG ARG B 137 10.198 5. ,574 -11. .852 1. .00 12. .37 c

ANISOU 2496 CG ARG B 137 1487 1607 1604 290 -90 -303 c

ATOM 2497 CD ARG B 137 9.133 6. .578 -12. .319 1. .00 14. .44 c

ANISOU 2497 CD ARG B 137 1122 2029 2335 251 - 543 -508 c

ATOM 2498 NE ARG B 137 7.807 6. .131 -11. .880 1. .00 16. .34 N

ANISOU 2498 NE ARG B 137 1402 2137 2668 139 - 322 -225 N

ATOM 2499 CZ ARG B 137 6.795 5. .802 -12. .685 1. .00 17. .10 C

ANISOU 2499 CZ ARG B 137 1136 2877 2482 274 - 122 -377 C

ATOM 2500 NH1 ARG B 137 6.897 5. .924 -14. .007 1. .00 18. .97 N

ANISOU 2500 NH1 ARG B 137 1704 3022 2481 33 - 249 -209 N

ATOM 2501 NH2 ARG B 137 5.661 5. .347 -12. .151 1. .00 16. .42 N

ANISOU 2501 NH2 ARG B 137 1321 2580 2338 413 352 -704 N

ATOM 2502 N LEU B 138 10.415 1. ,255 -13. .515 1. .00 14. .99 N

ANISOU 2502 N LEU B 138 1848 1948 1898 49 155 -135 N

ATOM 2503 CA LEU B 138 9.970 -0. ,112 -13. .762 1. .00 12. .90 C

ANISOU 2503 CA LEU B 138 1497 1610 1794 491 -55 -42 C

ATOM 2504 C LEU B 138 11.036 -1. ,183 -13. .478 1. .00 12. .70 C

ANISOU 2504 C LEU B 138 1617 1446 1762 415 -22 94 C

ATOM 2505 O LEU B 138 10.712 -2. ,286 -13. .046 1. .00 14. .29 O

ANISOU 2505 O LEU B 138 1970 1627 1833 -114 258 -98 O

ATOM 2506 CB LEU B 138 9.467 -0. ,246 -15. .200 1. .00 13. .82 C

ANISOU 2506 CB LEU B 138 1045 2167 2036 346 - 308 -23 C

ATOM 2507 CG LEU B 138 8.814 -1. ,578 -15. .559 1. .00 17. .98 C

ANISOU 2507 CG LEU B 138 1910 2497 2424 -131 47 -35 C

ATOM 2508 CD1 LEU B 138 7.465 -1. ,681 -14. .867 1. .00 20. .87 C

ANISOU 2508 CD1 LEU B 138 1622 3286 3019 -68 19 117 C

ATOM 2509 CD2 LEU B 138 8.666 -1. ,713 -17. .068 1. .00 19. .28 C

ANISOU 2509 CD2 LEU B 138 1731 3279 2316 462 185 -50 C

ATOM 2510 N LEU B 139 12.299 -0. ,848 -13. .714 1. .00 14. .67 N

ANISOU 2510 N LEU B 139 1561 1794 2218 331 - 193 -233 N

ATOM 2511 CA LEU B 139 13.333 -1. ,867 -13. .860 1. .00 13. .43 C

ANISOU 2511 CA LEU B 139 1245 2046 1809 280 - 383 -250 C

ATOM 2512 C LEU B 139 14.469 -1. ,790 -12. .838 1. .00 13. .21 C

ANISOU 2512 C LEU B 139 1137 1889 1990 -193 - 353 -431 C

ATOM 2513 O LEU B 139 15.471 -2. ,493 -12. .987 1. .00 14. .60 O

ANISOU 2513 O LEU B 139 1715 1973 1860 288 - 462 -349 O

ATOM 2514 CB LEU B 139 13.837 -1. ,877 -15. .313 1. .00 13. .42 C

ANISOU 2514 CB LEU B 139 1209 2200 1687 226 - 528 -201 C

ATOM 2515 CG LEU B 139 12.717 -2. ,215 -16. .343 1. .00 12. .14 C

ANISOU 2515 CG LEU B 139 1005 1788 1819 180 - 578 179 c

ATOM 2516 CD1 LEU B 139 13.060 -1. ,756 -17. .760 1. .00 14. .59 c

ANISOU 2516 CD1 LEU B 139 962 2772 1810 115 - 401 60 c

ATOM 2517 CD2 LEU B 139 12.343 -3. ,697 -16. .326 1. .00 17. .02 c ANISOU 2517 CD2 LEU B 139 2442 1859 2164 -11 -886 -357 C

ATOM 2518 N SER B 140 14.302 -0. ,961 -11. .803 1. .00 13. .76 N

ANISOU 2518 N SER B 140 1473 1973 1780 -251 -460 -369 N

ATOM 2519 CA SER B 140 15.248 -0. ,922 -10. .683 1. .00 13. .48 C

ANISOU 2519 CA SER B 140 1795 1603 1722 -142 -552 -277 C

ATOM 2520 C SER B 140 14.789 -1. ,885 -9. .590 1. .00 15. .23 C

ANISOU 2520 C SER B 140 1898 2118 1768 51 -167 -102 C

ATOM 2521 O SER B 140 13.598 -2. ,208 -9. .498 1. .00 17. .74 O

ANISOU 2521 O SER B 140 1773 2646 2318 67 -283 125 O

ATOM 2522 CB SER B 140 15.340 0. ,489 -10. .088 1. .00 15. .15 C

ANISOU 2522 CB SER B 140 2141 1714 1898 -322 -778 -417 C

ATOM 2523 OG SER B 140 15.840 1. .400 -11. .039 1. .00 15. .30 O

ANISOU 2523 OG SER B 140 1814 2096 1900 88 -376 -313 O

ATOM 2524 N SER B 141 15.739 -2. ,300 -8. .753 1. .00 15. .65 N

ANISOU 2524 N SER B 141 1922 1964 2060 370 -174 -95 N

ATOM 2525 CA SER B 141 15.502 -3. ,178 -7. .616 1. .00 13. .85 C

ANISOU 2525 CA SER B 141 1452 2125 1683 250 -272 -259 C

ATOM 2526 C SER B 141 14.763 -2. ,445 -6. .484 1. .00 16. .72 C

ANISOU 2526 C SER B 141 1685 2289 2379 561 93 -282 C

ATOM 2527 O SER B 141 13.954 -3. ,031 -5. .771 1. .00 19. .36 O

ANISOU 2527 O SER B 141 2708 1746 2901 296 453 -28 O

ATOM 2528 CB SER B 141 16.857 -3. ,651 -7. .076 1. .00 17. .60 C

ANISOU 2528 CB SER B 141 2087 2031 2569 1540 -19 27 C

ATOM 2529 OG SER B 141 16.688 -4. ,432 -5. .902 1. .00 28. .43 0

ANISOU 2529 OG SER B 141 3990 4444 2367 533 -204 46 0

ATOM 2530 N ARG B 142 15.083 -1. ,171 -6. .317 1. .00 14. .71 N

ANISOU 2530 N ARG B 142 1189 2283 2115 664 -323 -554 N

ATOM 2531 CA ARG B 142 14.647 -0. ,371 -5. .169 1. .00 16. .33 C

ANISOU 2531 CA ARG B 142 1935 2335 1933 507 140 -357 C

ATOM 2532 C ARG B 142 14.673 1. .093 -5. .571 1. .00 14. .91 C

ANISOU 2532 C ARG B 142 1737 2317 1609 609 18 -464 C

ATOM 2533 O ARG B 142 15.378 1. .477 -6. .520 1. .00 15. .81 O

ANISOU 2533 O ARG B 142 1781 2439 1784 343 71 -412 O

ATOM 2534 CB ARG B 142 15.627 -0. ,533 -3. .993 1. .00 22. .87 C

ANISOU 2534 CB ARG B 142 2908 3563 2217 1058 -269 163 c

ATOM 2535 CG ARG B 142 15.424 -1. ,765 -3. .128 1. .00 32. .91 c

ANISOU 2535 CG ARG B 142 4473 3999 4032 983 -109 734 c

ATOM 2536 CD ARG B 142 16.625 -2. ,010 -2. .223 1. .00 39. .27 c

ANISOU 2536 CD ARG B 142 5217 5950 3753 2229 -112 1717 c

ATOM 2537 NE ARG B 142 16.548 -3. ,310 -1. .547 1. .00 51. .78 N

ANISOU 2537 NE ARG B 142 8272 5753 5647 1807 502 1578 N

ATOM 2538 CZ ARG B 142 16.909 -4. ,481 -2. .081 1. .00 55. .14 C

ANISOU 2538 CZ ARG B 142 9165 7425 4358 2447 1368 962 C

ATOM 2539 NH1 ARG B 142 17.382 -4. ,559 -3. .324 1. .00 45. .93 N

ANISOU 2539 NH1 ARG B 142 4728 7947 4773 1344 1505 1368 N

ATOM 2540 NH2 ARG B 142 16.790 -5. ,591 -1. .362 1. .00 71. .20 N

ANISOU 2540 NH2 ARG B 142 10345 7745 8959 1651 743 2465 N

ATOM 2541 N ALA B 143 13.924 1. .913 -4. .841 1. .00 13. .61 N

ANISOU 2541 N ALA B 143 1374 1767 2026 139 -50 -749 N

ATOM 2542 CA ALA B 143 14.032 3. .363 -4. .957 1. .00 13. .78 C

ANISOU 2542 CA ALA B 143 1758 1872 1604 1 138 -301 C

ATOM 2543 C ALA B 143 13.810 4. .007 -3. .596 1. .00 13. .97 C

ANISOU 2543 C ALA B 143 1896 1830 1580 127 106 -224 C

ATOM 2544 O ALA B 143 13.112 3. .451 -2. .732 1. .00 15. .86 O

ANISOU 2544 O ALA B 143 1976 2258 1792 168 115 162 O

ATOM 2545 CB ALA B 143 13.049 3. .919 -5. .981 1. .00 16. .25 C

ANISOU 2545 CB ALA B 143 1947 2269 1955 203 -58 -348 C

ATOM 2546 N SER B 144 14.426 5. .167 -3. .405 1. .00 14. .00 N

ANISOU 2546 N SER B 144 1688 1848 1781 136 140 -276 N

ATOM 2547 CA SER B 144 14.227 5. .941 -2. .179 1. .00 15. .66 C

ANISOU 2547 CA SER B 144 2153 2112 1683 136 -46 -327 C ATOM 2548 C SER B 144 14.228 7..426 -2.,463 1..00 14., 62 C

ANISOU 2548 C SER B 144 1812 2200 1540 393 10 ^■148 C

ATOM 2549 O SER B 144 14.809 7. .871 -3. ,452 1. .00 15. , 98 O

ANISOU 2549 O SER B 144 1982 2229 1858 105 328 ^■287 O

ATOM 2550 CB SER B 144 15.324 5. .619 -1. ,162 1. .00 18. , 85 C

ANISOU 2550 CB SER B 144 2011 2710 2440 10 -179 383 C

ATOM 2551 OG SER B 144 16.547 6. .178 -1. ,583 1. .00 23. , 52 O

ANISOU 2551 OG SER B 144 1755 3112 4068 -186 -753 282 O

ATOM 2552 N GLN B 145 13.593 8. .201 -1. ,583 1. .00 13. ,81 N

ANISOU 2552 N GLN B 145 1452 2001 1793 327 -60 ^■239 N

ATOM 2553 CA GLN B 145 13.600 9. ,655 -1. ,727 1. .00 13. , 12 C

ANISOU 2553 CA GLN B 145 1340 2031 1612 102 -96 ^■254 C

ATOM 2554 C GLN B 145 13.298 10. .261 -0. ,391 1. .00 13. , 12 C

ANISOU 2554 C GLN B 145 1390 1718 1874 169 -47 ^■374 C

ATOM 2555 O GLN B 145 12.502 9. .713 0. .366 1, .00 16. .62 O

ANISOU 2555 O GLN B 145 1713 2517 2086 -57 221 ^■302 O

ATOM 2556 CB GLN B 145 12.571 10. .115 -2. ,773 1. .00 14. ,79 C

ANISOU 2556 CB GLN B 145 1576 2196 1848 -32 -245 -29 C

ATOM 2557 CG GLN B 145 12.710 11. .587 -3. ,185 1. .00 13. ,49 c

ANISOU 2557 CG GLN B 145 1742 2085 1297 85 -171 ^■254 c

ATOM 2558 CD GLN B 145 11.647 12. .028 -4. ,161 1. .00 13. ,16 c

ANISOU 2558 CD GLN B 145 1354 2195 1450 31 69 -17 c

ATOM 2559 OE1 GLN B 145 10.790 11. .239 -4. ,553 1. .00 15. ,49 0

ANISOU 2559 OE1 GLN B 145 1720 2171 1991 70 -181 ^■359 0

ATOM 2560 NE2 GLN B 145 11.682 13. .304 -4. ,549 1. .00 14. , 73 N

ANISOU 2560 NE2 GLN B 145 1577 2008 2009 -175 178 ^■295 N

ATOM 2561 N GLN B 146 13.939 11. .390 -0. ,110 1. .00 12. , 64 N

ANISOU 2561 N GLN B 146 1351 1623 1828 161 -166 ^■233 N

ATOM 2562 CA GLN B 146 13.626 12. ,213 1. ,049 1. .00 14. , 50 C

ANISOU 2562 CA GLN B 146 1447 2021 2041 130 -181 ^■574 C

ATOM 2563 C GLN B 146 13.031 13. .533 0. .614 1, .00 14. .73 C

ANISOU 2563 C GLN B 146 1592 2144 1861 219 -10 ^■595 C

ATOM 2564 O GLN B 146 13.282 14. .010 -0. ,499 1. .00 14. , 30 O

ANISOU 2564 O GLN B 146 1059 2305 2066 -268 279 ^■609 O

ATOM 2565 CB GLN B 146 14.890 12. .498 1. .856 1. .00 17. , 50 C

ANISOU 2565 CB GLN B 146 1875 2391 2381 297 -683 ^■551 C

ATOM 2566 CG GLN B 146 15.430 11. .259 2. .516 1, .00 21. .07 C

ANISOU 2566 CG GLN B 146 2133 2709 3163 417 -887 ^■184 C

ATOM 2567 CD GLN B 146 16.768 11. .473 3. .171 1, .00 22. .89 C

ANISOU 2567 CD GLN B 146 2746 2507 3443 38 -1296 ^■872 c

ATOM 2568 OE1 GLN B 146 17.094 12. .569 3. .609 1, .00 22. .29 0

ANISOU 2568 OE1 GLN B 146 2232 2523 3713 53 -1596 ^■826 0

ATOM 2569 NE2 GLN B 146 17.553 10. .409 3. .245 1, .00 26. .95 N

ANISOU 2569 NE2 GLN B 146 3013 3397 3826 818 -588 ^■456 N

ATOM 2570 N ILE B 147 12.246 14. .131 1. .504 1, .00 14. .45 N

ANISOU 2570 N ILE B 147 1030 1996 2462 292 198 ^■394 N

ATOM 2571 CA ILE B 147 11.634 15. ,424 1. ,242 1. .00 13. , 96 C

ANISOU 2571 CA ILE B 147 1138 2083 2081 201 -196 ^■231 C

ATOM 2572 C ILE B 147 11.561 16. .134 2. .593 1, .00 15. .56 C

ANISOU 2572 C ILE B 147 1307 2352 2250 201 -108 ^■414 C

ATOM 2573 O ILE B 147 11.340 15. .482 3. .636 1, .00 15. .79 O

ANISOU 2573 O ILE B 147 1426 2810 1760 512 -159 ^■621 O

ATOM 2574 CB ILE B 147 10.255 15. .250 0. .552 1, .00 14. .58 C

ANISOU 2574 CB ILE B 147 952 2239 2346 290 -75 ^■293 C

ATOM 2575 CGI ILE B 147 9.665 16. .610 0. .151 1, .00 15. .50 C

ANISOU 2575 CGI ILE B 147 1292 2314 2280 350 -480 ^■223 C

ATOM 2576 CG2 ILE B 147 9.315 14. .413 1. .418 1, .00 16. .67 C

ANISOU 2576 CG2 ILE B 147 1621 2456 2256 52 -73 -1 c

ATOM 2577 CD1 ILE B 147 8.490 16. ,510 -0. ,814 1. .00 16. ,79 c

ANISOU 2577 CD1 ILE B 147 1415 2869 2096 -103 -386 ^■569 c

ATOM 2578 N THR B 148 11.815 17. .443 2. .570 1, .00 15. .05 N ANISOU 2578 N THR B 148 1514 2216 1986 531 -258 -877 N

ATOM 2579 CA THR B 148 11.891 18. .272 3. .761 1. .00 15. .37 C

ANISOU 2579 CA THR B 148 1420 2382 2035 299 - 236 -920 C

ATOM 2580 C THR B 148 10.751 19. .267 3. .772 1. .00 15. .71 C

ANISOU 2580 C THR B 148 1676 2194 2096 388 86 -667 C

ATOM 2581 O THR B 148 10.563 20. .054 2. .837 1. .00 16. .27 O

ANISOU 2581 O THR B 148 1402 2564 2213 133 260 -406 O

ATOM 2582 CB THR B 148 13.261 18. .968 3. .843 1. .00 17. .04 C

ANISOU 2582 CB THR B 148 1361 2622 2491 286 -66 -791 C

ATOM 2583 OG1 THR B 148 14.247 17. .945 4. .000 1. .00 20. .21 O

ANISOU 2583 OG1 THR B 148 1249 3014 3413 478 49 -990 O

ATOM 2584 CG2 THR B 148 13.341 19. .941 5. .027 1. .00 18. .19 C

ANISOU 2584 CG2 THR B 148 1518 2945 2447 -228 - 592 -780 C

ATOM 2585 N TYR B 149 9.978 19. .220 4. .843 1. .00 15. .62 N

ANISOU 2585 N TYR B 149 1658 2327 1948 493 -54 -636 N

ATOM 2586 CA TYR B 149 8.922 20. .200 5. .063 1. .00 15. .69 C

ANISOU 2586 CA TYR B 149 1644 2016 2301 254 172 -783 C

ATOM 2587 C TYR B 149 9.441 21. .258 6. .044 1. .00 16. .09 C

ANISOU 2587 C TYR B 149 2128 1659 2323 145 -27 -530 C

ATOM 2588 O TYR B 149 9.718 20. ,944 7. ,193 1. , 00 17. , 66 O

ANISOU 2588 O TYR B 149 2116 2685 1909 -322 104 - 1005 O

ATOM 2589 CB TYR B 149 7.713 19. .482 5. .644 1. .00 14. .59 C

ANISOU 2589 CB TYR B 149 1678 1967 1898 383 196 -611 C

ATOM 2590 CG TYR B 149 6.481 20. .335 5. .871 1. .00 14. .57 c

ANISOU 2590 CG TYR B 149 1097 2511 1926 249 -11 -559 c

ATOM 2591 CD1 TYR B 149 5.628 20. .670 4. .806 1. , 00 15. , 68 c

ANISOU 2591 CD1 TYR B 149 1857 2286 1814 241 - 154 -434 c

ATOM 2592 CD2 TYR B 149 6.122 20. .765 7. .164 1. .00 14. .90 c

ANISOU 2592 CD2 TYR B 149 1748 1996 1917 231 - 144 -618 c

ATOM 2593 CE1 TYR B 149 4.475 21. .418 5. .017 1. .00 14. .95 c

ANISOU 2593 CE1 TYR B 149 1513 2067 2100 -46 - 310 -573 c

ATOM 2594 CE2 TYR B 149 4.955 21. .501 7. .380 1. .00 16. .08 c

ANISOU 2594 CE2 TYR B 149 1320 2363 2426 23 -99 -545 c

ATOM 2595 CZ TYR B 149 4.140 21. .831 6. .303 1. .00 15. .80 c

ANISOU 2595 CZ TYR B 149 1657 2051 2295 214 -61 -599 c

ATOM 2596 OH TYR B 149 2.974 22. .569 6. .511 1. .00 18. .22 0

ANISOU 2596 OH TYR B 149 1484 2524 2915 253 - 173 -797 0

ATOM 2597 N HIS B 150 9.593 22. .490 5. .571 1. .00 15. .52 N

ANISOU 2597 N HIS B 150 1721 1705 2470 118 170 -402 N

ATOM 2598 CA HIS B 150 9.906 23. .649 6. .419 1. .00 15. .75 C

ANISOU 2598 CA HIS B 150 1626 2245 2113 262 220 -691 c

ATOM 2599 C HIS B 150 8.635 24. .215 7. .010 1. .00 15. .93 c

ANISOU 2599 C HIS B 150 1387 2608 2058 336 82 -277 c

ATOM 2600 O HIS B 150 7.679 24. .463 6. .282 1. .00 14. .53 0

ANISOU 2600 O HIS B 150 1121 2462 1937 200 166 -283 0

ATOM 2601 CB HIS B 150 10.606 24. .708 5. .587 1. .00 17. .88 c

ANISOU 2601 CB HIS B 150 2132 2331 2329 -14 -44 -632 c

ATOM 2602 CG HIS B 150 11.978 24. ,297 5. ,119 1. , 00 21. , 28 c

ANISOU 2602 CG HIS B 150 1914 3089 3082 -232 2 -834 c

ATOM 2603 ND1 HIS B 150 13.070 24. .396 5. .909 1. .00 25. .39 N

ANISOU 2603 ND1 HIS B 150 2526 3776 3342 202 - 505 -839 N

ATOM 2604 CD2 HIS B 150 12.414 23. .765 3. .910 1. .00 22. .44 C

ANISOU 2604 CD2 HIS B 150 1834 3339 3351 -206 258 -923 C

ATOM 2605 CE1 HIS B 150 14.153 23. .953 5. .233 1. .00 25. .88 C

ANISOU 2605 CE1 HIS B 150 2783 3862 3185 -514 300 -635 C

ATOM 2606 NE2 HIS B 150 13.752 23. .567 4. .012 1. .00 23. .84 N

ANISOU 2606 NE2 HIS B 150 1968 3349 3737 205 131 - 1465 N

ATOM 2607 N CYS B 151 8.616 24. .447 8. .322 1. .00 14. .93 N

ANISOU 2607 N CYS B 151 1278 2316 2077 8 354 -586 N

ATOM 2608 CA CYS B 151 7.352 24. ,745 9. ,019 1. , 00 14. , 47 C

ANISOU 2608 CA CYS B 151 1218 2119 2160 358 118 -607 C ATOM 2609 C CYS B 151 7.469 25..943 9..936 1..00 16..73 C

ANISOU 2609 C CYS B 151 2010 2041 2305 213 13 -604 C

ATOM 2610 O CYS B 151 8.449 26. .080 10. .686 1. .00 17. .98 O

ANISOU 2610 O CYS B 151 2047 2332 2450 145 -151 -615 O

ATOM 2611 CB CYS B 151 6.925 23. .559 9. .877 1. .00 14. .81 C

ANISOU 2611 CB CYS B 151 1457 2434 1734 202 -250 -475 C

ATOM 2612 SG CYS B 151 8.210 23. .045 11. .054 1. .00 17. .20 S

ANISOU 2612 SG CYS B 151 1710 2749 2073 200 -552 -497 S

ATOM 2613 N LYS B 152 6.455 26. .797 9. .887 1. .00 16. .83 N

ANISOU 2613 N LYS B 152 2359 1755 2280 337 -259 -990 N

ATOM 2614 CA LYS B 152 6.242 27. .831 10. .916 1. .00 15. .45 C

ANISOU 2614 CA LYS B 152 1823 1702 2344 -53 -324 - 1116 C

ATOM 2615 C LYS B 152 4.797 27. .726 11. .415 1. .00 17. .20 C

ANISOU 2615 C LYS B 152 2087 2248 2199 -116 -68 -633 C

ATOM 2616 O LYS B 152 3.852 27. .907 10. .633 1. .00 19. .65 O

ANISOU 2616 O LYS B 152 2255 2887 2322 543 -18 -641 O

ATOM 2617 CB LYS B 152 6.503 29. ,228 10. ,352 1. ,00 18. ,86 C

ANISOU 2617 CB LYS B 152 2755 2194 2215 186 -80 -387 C

ATOM 2618 CG LYS B 152 6.368 30. .351 11. .379 1. .00 22. .51 c

ANISOU 2618 CG LYS B 152 3250 2121 3180 15 -236 -811 c

ATOM 2619 CD LYS B 152 6.478 31. .731 10. .731 1. .00 28. .56 c

ANISOU 2619 CD LYS B 152 4414 2270 4164 63 -188 -496 c

ATOM 2620 CE LYS B 152 6.231 32. .836 11. .742 1. .00 30. .05 c

ANISOU 2620 CE LYS B 152 4624 2575 4218 235 -1021 -742 c

ATOM 2621 NZ LYS B 152 6.587 34. .158 11. .168 1. .00 38. .95 N

ANISOU 2621 NZ LYS B 152 5897 3858 5043 703 -261 984 N

ATOM 2622 N ASN B 153 4.617 27. .422 12. .696 1. .00 16. .81 N

ANISOU 2622 N ASN B 153 1692 2737 1957 -22 -197 -805 N

ATOM 2623 CA ASN B 153 3.278 27. ,192 13. ,253 1. ,00 17. , 47 C

ANISOU 2623 CA ASN B 153 1809 2430 2399 64 5 - 1054 C

ATOM 2624 C ASN B 153 2.496 26. .132 12. .468 1. .00 18. .73 C

ANISOU 2624 C ASN B 153 2395 2403 2318 29 -153 - 1104 C

ATOM 2625 O ASN B 153 1.297 26. .297 12. .200 1. .00 20. .14 O

ANISOU 2625 O ASN B 153 2423 2620 2608 328 -13 -783 O

ATOM 2626 CB ASN B 153 2.482 28. .504 13. .293 1. .00 19. .52 C

ANISOU 2626 CB ASN B 153 2388 2272 2757 152 -200 -843 C

ATOM 2627 CG ASN B 153 3.133 29. .554 14. .165 1. .00 18. .49 C

ANISOU 2627 CG ASN B 153 1993 2456 2575 -135 173 -819 C

ATOM 2628 OD1 ASN B 153 3.660 29. .240 15. .226 1. .00 22. .96 O

ANISOU 2628 OD1 ASN B 153 2814 3214 2692 367 -123 - 1178 0

ATOM 2629 ND2 ASN B 153 3.087 30. ,808 13. ,729 1. ,00 18. , 31 N

ANISOU 2629 ND2 ASN B 153 1678 2346 2932 -418 -320 -777 N

ATOM 2630 N SER B 154 3.180 25. .057 12. .086 1. .00 15. .75 N

ANISOU 2630 N SER B 154 1818 1749 2416 -308 -382 -677 N

ATOM 2631 CA SER B 154 2.572 24. .036 11. .239 1. .00 17. .35 C

ANISOU 2631 CA SER B 154 2451 1946 2192 -242 -206 -993 C

ATOM 2632 C SER B 154 3.109 22. .660 11. .579 1. ,00 18. ,26 C

ANISOU 2632 C SER B 154 2077 2338 2523 -10 -67 -470 C

ATOM 2633 O SER B 154 4.269 22. .365 11. .320 1. .00 17. .67 O

ANISOU 2633 O SER B 154 2004 2267 2441 -58 57 -152 O

ATOM 2634 CB SER B 154 2.815 24. .337 9. .752 1. .00 18. .80 C

ANISOU 2634 CB SER B 154 2625 2187 2330 -285 -209 -661 C

ATOM 2635 OG SER B 154 2.239 23. .320 8. .925 1. .00 17. .50 O

ANISOU 2635 OG SER B 154 1690 2156 2802 151 -320 -871 O

ATOM 2636 N ILE B 155 2.256 21. .813 12. .146 1. .00 16. .93 N

ANISOU 2636 N ILE B 155 1654 2381 2395 -77 -172 -795 N

ATOM 2637 CA ILE B 155 2.629 20. .433 12. .444 1. .00 17. .63 C

ANISOU 2637 CA ILE B 155 2126 2510 2059 -158 129 -393 C

ATOM 2638 C ILE B 155 2.827 19. .646 11. .141 1. .00 15. .76 C

ANISOU 2638 C ILE B 155 1545 2497 1946 15 1 -353 C

ATOM 2639 O ILE B 155 2.011 19. .754 10. .217 1. .00 17. .50 O ANISOU 2639 O ILE B 155 1593 2931 2124 180 -210 -632 O

ATOM 2640 CB ILE B 155 1.576 19. .773 13. .360 1. .00 18. .24 C

ANISOU 2640 CB ILE B 155 1731 2830 2367 169 676 -821 C

ATOM 2641 CGI ILE B 155 1.660 20. .402 14. .764 1. .00 22. .44 C

ANISOU 2641 CGI ILE B 155 3221 2769 2535 529 550 -949 C

ATOM 2642 CG2 ILE B 155 1.756 18. .252 13. .424 1. .00 17. .46 C

ANISOU 2642 CG2 ILE B 155 1521 2710 2403 -585 336 -534 C

ATOM 2643 CD1 ILE B 155 0.320 20. ,551 15. ,439 1. ,00 32. , 05 C

ANISOU 2643 CD1 ILE B 155 3566 4261 4348 445 1121 -288 C

ATOM 2644 N ALA B 156 3.920 18. .882 11. .059 1. .00 18. .14 N

ANISOU 2644 N ALA B 156 2142 2606 2144 344 -75 -498 N

ATOM 2645 CA ALA B 156 4.227 18. .067 9. .880 1. .00 16. .96 C

ANISOU 2645 CA ALA B 156 1733 2562 2148 288 331 -397 C

ATOM 2646 C ALA B 156 3.912 16. .579 10. .090 1. ,00 17. , 02 C

ANISOU 2646 C ALA B 156 1452 2759 2254 78 -45 -490 C

ATOM 2647 O ALA B 156 3.483 15. .874 9. .153 1. .00 17. .02 O

ANISOU 2647 O ALA B 156 1740 2859 1866 114 100 -471 O

ATOM 2648 CB ALA B 156 5.698 18. .215 9. .525 1. .00 18. .59 C

ANISOU 2648 CB ALA B 156 1548 3190 2324 242 -107 -152 C

ATOM 2649 N TYR B 157 4.175 16. .102 11. .301 1. .00 18. .65 N

ANISOU 2649 N TYR B 157 2013 2876 2196 55 450 -183 N

ATOM 2650 CA TYR B 157 4.044 14. .691 11. .628 1. .00 18. .75 C

ANISOU 2650 CA TYR B 157 2106 2819 2196 21 345 -395 C

ATOM 2651 C TYR B 157 3.437 14. .547 13. .031 1. .00 20. .38 C

ANISOU 2651 C TYR B 157 2619 3072 2051 -335 288 -573 C

ATOM 2652 O TYR B 157 2.217 14. .478 13. .164 1. .00 21. .94 O

ANISOU 2652 O TYR B 157 2609 3273 2453 -484 336 -640 O

ATOM 2653 CB TYR B 157 5.403 13. .982 11. .474 1. .00 17. .74 C

ANISOU 2653 CB TYR B 157 1986 2601 2150 -7 -164 -256 C

ATOM 2654 CG TYR B 157 5.393 12. .510 11. .833 1. .00 18. .14 c

ANISOU 2654 CG TYR B 157 2325 2474 2092 -52 276 -483 c

ATOM 2655 CD1 TYR B 157 4.638 11. .587 11. .099 1. .00 20. .57 c

ANISOU 2655 CD1 TYR B 157 3111 2522 2180 -249 202 -633 c

ATOM 2656 CD2 TYR B 157 6.135 12. .042 12. .916 1. .00 20. .29 c

ANISOU 2656 CD2 TYR B 157 2801 2595 2311 173 261 -188 c

ATOM 2657 CE1 TYR B 157 4.633 10. ,236 11. ,440 1. ,00 22. ,01 c

ANISOU 2657 CE1 TYR B 157 3314 2817 2230 461 397 48 c

ATOM 2658 CE2 TYR B 157 6.133 10. .699 13. .266 1. .00 21. .21 c

ANISOU 2658 CE2 TYR B 157 3290 2558 2210 172 523 -302 c

ATOM 2659 CZ TYR B 157 5.384 9. .804 12. .533 1. .00 24. .23 c

ANISOU 2659 CZ TYR B 157 4126 2359 2720 283 -273 -173 c

ATOM 2660 OH TYR B 157 5.407 8. .481 12. .906 1. .00 29. .57 0

ANISOU 2660 OH TYR B 157 5143 2404 3686 384 -82 96 0

ATOM 2661 N MET B 158 4.281 14. .529 14. .064 1. .00 21. .08 N

ANISOU 2661 N MET B 158 3161 3036 1813 266 239 -582 N

ATOM 2662 CA MET B 158 3.832 14. .469 15. .458 1. .00 21. .90 C

ANISOU 2662 CA MET B 158 3424 2894 2002 229 576 -605 c

ATOM 2663 C MET B 158 3.309 15. ,837 15. ,923 1. ,00 21. , 83 c

ANISOU 2663 C MET B 158 3104 2906 2284 239 641 -515 c

ATOM 2664 O MET B 158 3.909 16. .867 15. .624 1. .00 20. .92 0

ANISOU 2664 O MET B 158 2674 2814 2459 178 307 -639 0

ATOM 2665 CB MET B 158 5.001 14. .016 16. .354 1. .00 26. .32 c

ANISOU 2665 CB MET B 158 3645 3487 2866 457 62 -695 c

ATOM 2666 CG MET B 158 4.673 13. .831 17. .826 1. .00 32. .52 c

ANISOU 2666 CG MET B 158 4604 4594 3159 329 -164 906 c

ATOM 2667 SD MET B 158 3.299 12. .700 18. .116 1. .00 41. .30 s

ANISOU 2667 SD MET B 158 5420 5434 4838 167 822 964 s

ATOM 2668 CE MET B 158 3.998 11. .111 17. .668 1. .00 35. .67 c

ANISOU 2668 CE MET B 158 2997 5515 5038 -310 1139 697 c

ATOM 2669 N ASP B 159 2.189 15. ,829 16. ,645 1. ,00 23. , 28 N

ANISOU 2669 N ASP B 159 2943 3385 2517 201 633 - 1044 N ATOM 2670 CA ASP B 159 1.625 17..021 17..298 1,.00 25..16 C

ANISOU 2670 CA ASP B 159 3690 3695 2172 215 676 - 1311 C

ATOM 2671 C ASP B 159 1.927 16. .856 18. .779 1, .00 27. .28 C

ANISOU 2671 C ASP B 159 3768 4148 2448 -171 179 - 1154 C

ATOM 2672 O ASP B 159 1.335 15. .999 19. .440 1. .00 29. , 70 O

ANISOU 2672 O ASP B 159 4065 4941 2278 -186 212 -644 O

ATOM 2673 CB ASP B 159 0.111 17. .081 17. .045 1, .00 27. .77 C

ANISOU 2673 CB ASP B 159 3791 4317 2441 347 490 - 1235 C

ATOM 2674 CG ASP B 159 -0.588 18. ,216 17. ,793 1. .00 29. , 78 C

ANISOU 2674 CG ASP B 159 3163 4776 3375 896 1051 -829 C

ATOM 2675 OD1 ASP B 159 0.081 19. .065 18. .412 1, .00 36. .07 O

ANISOU 2675 OD1 ASP B 159 4565 4726 4413 572 997 - 1175 O

ATOM 2676 OD2 ASP B 159 -1.833 18. ,262 17. ,763 1. .00 37. , 07 O

ANISOU 2676 OD2 ASP B 159 3294 6823 3966 649 520 - 1024 O

ATOM 2677 N GLN B 160 2.857 17. .656 19. .303 1, .00 25. .78 N

ANISOU 2677 N GLN B 160 2578 4816 2400 -240 287 -568 N

ATOM 2678 CA GLN B 160 3.314 17. ,465 20. ,686 1. .00 31. , 17 C

ANISOU 2678 CA GLN B 160 3851 5289 2700 -347 -373 -556 C

ATOM 2679 C GLN B 160 2.166 17. .628 21. .692 1, .00 29. .81 C

ANISOU 2679 C GLN B 160 4526 4403 2396 27 -126 -909 C

ATOM 2680 O GLN B 160 2.100 16. .902 22. .687 1, .00 30. .94 O

ANISOU 2680 O GLN B 160 4556 4278 2920 -388 2 -606 O

ATOM 2681 CB GLN B 160 4.519 18. .370 21. .030 1, .00 28. .76 C

ANISOU 2681 CB GLN B 160 4354 3721 2852 -57 -655 -561 C

ATOM 2682 CG GLN B 160 5.235 17. .978 22. .325 1, .00 35. .30 c

ANISOU 2682 CG GLN B 160 5545 4891 2973 406 -383 450 c

ATOM 2683 CD GLN B 160 6.441 18. .847 22. .644 1, .00 38. .80 c

ANISOU 2683 CD GLN B 160 6460 5051 3228 30 -402 258 c

ATOM 2684 OE1 GLN B 160 7.375 18. ,964 21. ,849 1. .00 46. , 56 0

ANISOU 2684 OE1 GLN B 160 6093 4729 6869 765 718 778 0

ATOM 2685 NE2 GLN B 160 6.429 19. .453 23. .813 1, .00 45. .24 N

ANISOU 2685 NE2 GLN B 160 7108 6191 3888 -185 -1477 -631 N

ATOM 2686 N ALA B 161 1.245 18. .542 21. .397 1, .00 29. .49 N

ANISOU 2686 N ALA B 161 3959 4640 2603 70 218 - 1143 N

ATOM 2687 CA ALA B 161 0.123 18. .843 22. .296 1, .00 33. .84 C

ANISOU 2687 CA ALA B 161 4749 5050 3056 -41 1257 -405 C

ATOM 2688 C ALA B 161 -0.803 17. ,642 22. ,501 1. .00 36. , 95 C

ANISOU 2688 C ALA B 161 5062 5675 3301 -416 1396 -91 C

ATOM 2689 O ALA B 161 -1.207 17. ,348 23. ,633 1. .00 42. , 78 O

ANISOU 2689 O ALA B 161 5866 6543 3844 -690 1920 381 O

ATOM 2690 CB ALA B 161 -0.665 20. ,037 21. ,775 1. .00 37. , 03 C

ANISOU 2690 CB ALA B 161 5052 5502 3515 277 1627 19 C

ATOM 2691 N SER B 162 -1.128 16. ,956 21. ,406 1. .00 39. , 07 N

ANISOU 2691 N SER B 162 5264 6628 2953 -593 1317 -137 N

ATOM 2692 CA SER B 162 -2.032 15. ,798 21. ,421 1. .00 38. , 45 C

ANISOU 2692 CA SER B 162 4927 6947 2735 -686 1194 374 C

ATOM 2693 C SER B 162 -1.278 14. ,508 21. ,696 1. .00 36. , 57 C

ANISOU 2693 C SER B 162 4799 6846 2248 -908 973 502 C

ATOM 2694 O SER B 162 -1.842 13. ,551 22. ,222 1. .00 36. ,29 O

ANISOU 2694 O SER B 162 4963 6087 2737 -1047 1378 -483 O

ATOM 2695 CB SER B 162 -2.743 15. ,640 20. ,073 1. .00 44. , 35 C

ANISOU 2695 CB SER B 162 5625 7359 3867 -1165 -236 869 C

ATOM 2696 OG SER B 162 -3.075 16. ,890 19. ,501 1. .00 51. , 12 0

ANISOU 2696 OG SER B 162 6778 7874 4770 -911 -845 934 0

ATOM 2697 N GLY B 163 -0.008 14. ,485 21. ,300 1. .00 36. , 28 N

ANISOU 2697 N GLY B 163 4562 7277 1944 261 511 -42 N

ATOM 2698 CA GLY B 163 0.820 13. ,289 21. ,392 1. .00 37. , 98 C

ANISOU 2698 CA GLY B 163 5495 5675 3261 -437 1500 413 C

ATOM 2699 C GLY B 163 0.575 12. .318 20. .248 1, .00 36. .41 C

ANISOU 2699 C GLY B 163 5364 4318 4149 -181 547 720 C

ATOM 2700 O GLY B 163 1.032 11. .180 20. .295 1, .00 40. .60 O ANISOU 2700 O GLY B 163 5853 3992 5580 -137 746 1071 O

ATOM 2701 N ASN B 164 -0.132 12. ,765 19. ,210 1. .00 33. .48 N

ANISOU 2701 N ASN B 164 4688 5464 2568 -422 751 -551 N

ATOM 2702 CA ASN B 164 -0.499 11. ,873 18. ,108 1. .00 31. .09 C

ANISOU 2702 CA ASN B 164 3905 5298 2607 -625 1379 -673 C

ATOM 2703 C ASN B 164 -0.174 12. ,422 16. ,699 1. .00 27. .93 C

ANISOU 2703 C ASN B 164 4056 3935 2618 -444 1031 -731 C

ATOM 2704 O ASN B 164 0.206 13. .596 16. .540 1, .00 24, .96 O

ANISOU 2704 O ASN B 164 3087 3883 2512 -144 1398 -644 O

ATOM 2705 CB ASN B 164 -1.968 11. ,425 18. ,249 1. .00 33. .35 C

ANISOU 2705 CB ASN B 164 4081 4677 3911 -934 1089 -684 C

ATOM 2706 CG ASN B 164 -2.950 12. ,505 17. ,851 1. .00 37. .23 C

ANISOU 2706 CG ASN B 164 4559 5562 4021 -523 1174 -156 c

ATOM 2707 OD1 ASN B 164 -2.742 13. ,200 16. ,855 1. .00 29. .60 0

ANISOU 2707 OD1 ASN B 164 2960 4851 3433 -279 754 -722 0

ATOM 2708 ND2 ASN B 164 -4.036 12. ,647 18. ,621 1. .00 35. .42 N

ANISOU 2708 ND2 ASN B 164 4486 4234 4737 -1227 1448 -776 N

ATOM 2709 N VAL B 165 -0.318 11. ,563 15. ,690 1. .00 26. .54 N

ANISOU 2709 N VAL B 165 3682 3883 2517 -785 1108 -700 N

ATOM 2710 CA VAL B 165 0.090 11. .903 14. .324 1, .00 24, .77 C

ANISOU 2710 CA VAL B 165 3732 3326 2353 -439 805 -755 C

ATOM 2711 C VAL B 165 -1.113 12. ,155 13. ,405 1. .00 25. .58 C

ANISOU 2711 C VAL B 165 3586 3287 2845 -169 995 -678 C

ATOM 2712 O VAL B 165 -1.027 12. ,005 12. ,189 1. .00 26. .72 O

ANISOU 2712 O VAL B 165 3285 4245 2622 -810 868 7 O

ATOM 2713 CB VAL B 165 1.051 10. .846 13. .723 1, .00 24, .71 C

ANISOU 2713 CB VAL B 165 2749 3601 3036 -220 571 -130 C

ATOM 2714 CGI VAL B 165 2.350 10. .792 14. .520 1, .00 23, .89 C

ANISOU 2714 CGI VAL B 165 2488 3476 3111 428 673 -54 C

ATOM 2715 CG2 VAL B 165 0.413 9. .465 13. .670 1, .00 27, .68 C

ANISOU 2715 CG2 VAL B 165 4109 3399 3009 -346 745 -543 c

ATOM 2716 N LYS B 166 -2.224 12. ,541 13. ,987 1. .00 26. .20 N

ANISOU 2716 N LYS B 166 3792 3380 2782 -214 1342 -427 N

ATOM 2717 CA LYS B 166 -3.438 12. ,749 13. ,193 1. .00 27. .69 C

ANISOU 2717 CA LYS B 166 3655 4038 2828 -584 1318 -170 C

ATOM 2718 C LYS B 166 -3.341 13. ,910 12. ,214 1. .00 25. .14 C

ANISOU 2718 C LYS B 166 3239 3451 2861 -205 713 -434 C

ATOM 2719 O LYS B 166 -4.067 13. ,949 11. ,228 1. .00 26. .09 O

ANISOU 2719 O LYS B 166 3018 3816 3077 -856 573 - 1023 O

ATOM 2720 CB LYS B 166 -4.648 12. ,942 14. ,100 1. .00 23. .58 c

ANISOU 2720 CB LYS B 166 2875 3224 2859 -93 542 -85 c

ATOM 2721 CG LYS B 166 -4.971 11. ,701 14. ,909 1. .00 25. .58 c

ANISOU 2721 CG LYS B 166 3225 3220 3272 -211 316 149 c

ATOM 2722 CD LYS B 166 -6.076 11. ,987 15. ,924 1. .00 27. .75 c

ANISOU 2722 CD LYS B 166 3028 4085 3430 350 150 301 c

ATOM 2723 CE LYS B 166 -7.378 12. ,361 15. ,226 1. .00 27. .63 c

ANISOU 2723 CE LYS B 166 2791 4269 3437 63 130 180 c

ATOM 2724 NZ LYS B 166 -8.461 12. ,587 16. ,226 1. .00 31. .55 N

ANISOU 2724 NZ LYS B 166 3589 4417 3979 233 532 17 N

ATOM 2725 N LYS B 167 -2.464 14. ,847 12. ,490 1. .00 23. .30 N

ANISOU 2725 N LYS B 167 3023 3018 2809 -89 1097 -249 N

ATOM 2726 CA LYS B 167 -2.274 16. ,011 11. ,632 1. .00 18. .65 C

ANISOU 2726 CA LYS B 167 2397 2573 2115 218 910 -686 C

ATOM 2727 C LYS B 167 -1.127 15. ,819 10. ,642 1. .00 18. .79 C

ANISOU 2727 C LYS B 167 1905 3033 2201 -16 731 -587 C

ATOM 2728 O LYS B 167 -0.764 16. ,758 9. ,921 1. .00 21. .07 O

ANISOU 2728 O LYS B 167 2416 2990 2599 -76 519 -424 O

ATOM 2729 CB LYS B 167 -2.028 17. ,264 12. ,476 1. .00 18. .89 C

ANISOU 2729 CB LYS B 167 1612 2835 2731 -348 1046 -967 C

ATOM 2730 CG LYS B 167 -3.220 17. ,658 13. ,347 1. .00 22. .39 C

ANISOU 2730 CG LYS B 167 2028 3353 3126 3 1510 -537 C ATOM 2731 CD LYS B 167 -2.949 18.,909 14.,177 1..00 26., 00 C

ANISOU 2731 CD LYS B 167 3345 3414 3117 78 911 -506 C

ATOM 2732 CE LYS B 167 -3.988 19. ,030 15. ,281 1. .00 29. , 27 C

ANISOU 2732 CE LYS B 167 3283 3940 3897 420 1167 - 1093 C

ATOM 2733 NZ LYS B 167 -3.848 20. ,282 16. ,066 1. .00 34. , 74 N

ANISOU 2733 NZ LYS B 167 4982 3785 4433 158 2403 - 1069 N

ATOM 2734 N ALA B 168 -0.565 14. ,610 10. ,585 1. .00 17. , 90 N

ANISOU 2734 N ALA B 168 1775 2886 2139 -194 423 -807 N

ATOM 2735 CA ALA B 168 0.598 14. .372 9. .703 1, .00 18. .05 C

ANISOU 2735 CA ALA B 168 2101 2662 2093 -237 763 -289 C

ATOM 2736 C ALA B 168 0.266 14. .658 8. .234 1, .00 18. .20 C

ANISOU 2736 C ALA B 168 1864 2789 2262 -558 465 -267 C

ATOM 2737 O ALA B 168 -0.833 14. ,355 7. ,760 1. .00 19. , 58 O

ANISOU 2737 O ALA B 168 1826 3179 2434 -294 437 -681 O

ATOM 2738 CB ALA B 168 1.139 12. ,953 9. ,864 1. .00 17. , 83 C

ANISOU 2738 CB ALA B 168 2060 2581 2132 -336 293 -517 C

ATOM 2739 N LEU B 169 1.224 15. .239 7. .511 1, .00 16. .06 N

ANISOU 2739 N LEU B 169 1697 2256 2146 -90 497 -163 N

ATOM 2740 CA LEU B 169 1.052 15. .485 6. .088 1, .00 14. .57 C

ANISOU 2740 CA LEU B 169 1396 1969 2171 -259 121 -426 C

ATOM 2741 C LEU B 169 1.091 14. .176 5. .277 1, .00 13. .79 C

ANISOU 2741 C LEU B 169 961 2158 2118 -98 7 -571 C

ATOM 2742 O LEU B 169 1.475 13. .124 5. .808 1, .00 15. .32 O

ANISOU 2742 O LEU B 169 1297 2225 2296 40 142 -452 O

ATOM 2743 CB LEU B 169 2.082 16. .521 5. .597 1, .00 12. .21 C

ANISOU 2743 CB LEU B 169 964 1669 2003 2 33 -501 C

ATOM 2744 CG LEU B 169 3.574 16. .185 5. .656 1, .00 14. .27 C

ANISOU 2744 CG LEU B 169 1072 2175 2175 247 -37 -662 c

ATOM 2745 CD1 LEU B 169 3.914 15. .201 4. .556 1, .00 13. .82 c

ANISOU 2745 CD1 LEU B 169 1000 2110 2138 -192 -19 -736 c

ATOM 2746 CD2 LEU B 169 4.375 17. .475 5. .489 1, .00 15. .54 c

ANISOU 2746 CD2 LEU B 169 1621 2262 2019 152 -142 -298 c

ATOM 2747 N LYS B 170 0.611 14. .234 4. .024 1, .00 14. .71 N

ANISOU 2747 N LYS B 170 1474 2055 2060 -397 -119 -931 N

ATOM 2748 CA LYS B 170 0.714 13. .110 3. .090 1, .00 15. .33 C

ANISOU 2748 CA LYS B 170 1256 2256 2312 -153 -29 - 1131 C

ATOM 2749 C LYS B 170 1.574 13. .488 1. .882 1, .00 15. .56 C

ANISOU 2749 C LYS B 170 1601 2019 2290 -199 -35 - 1005 C

ATOM 2750 O LYS B 170 1.752 14. .679 1. .577 1, .00 14. .48 O

ANISOU 2750 O LYS B 170 1181 2225 2095 -45 -86 -472 0

ATOM 2751 CB LYS B 170 -0.669 12. ,695 2. ,574 1. .00 20. , 50 c

ANISOU 2751 CB LYS B 170 1805 3030 2952 -1090 -50 - 1644 c

ATOM 2752 CG LYS B 170 -1.654 12. ,245 3. ,628 1. .00 24. , 20 c

ANISOU 2752 CG LYS B 170 2762 3256 3177 -1340 478 - 1798 c

ATOM 2753 CD LYS B 170 -2.898 11. ,620 2. ,988 1. .00 26. , 43 c

ANISOU 2753 CD LYS B 170 2481 3829 3729 -643 -310 - 1693 c

ATOM 2754 CE LYS B 170 -3.751 12. ,607 2. ,183 1. .00 23. , 78 c

ANISOU 2754 CE LYS B 170 2072 1945 5017 -589 195 - 1913 c

ATOM 2755 NZ LYS B 170 -5.001 11. ,932 1. ,674 1. .00 24. , 80 N

ANISOU 2755 NZ LYS B 170 1508 3106 4807 -793 931 - 2118 N

ATOM 2756 N LEU B 171 2.099 12. .467 1. .206 1, .00 14. .35 N

ANISOU 2756 N LEU B 171 1333 2337 1781 85 22 -814 N

ATOM 2757 CA LEU B 171 2.880 12. .619 -0. ,028 1. .00 14. ,76 C

ANISOU 2757 CA LEU B 171 1676 2308 1622 6 -39 -524 C

ATOM 2758 C LEU B 171 2.199 11. .841 -1. ,154 1. .00 13. , 33 C

ANISOU 2758 C LEU B 171 1571 2223 1270 481 118 -615 C

ATOM 2759 O LEU B 171 1.599 10. .802 -0. ,911 1. .00 18. , 07 O

ANISOU 2759 O LEU B 171 2300 2705 1860 -70 281 -545 O

ATOM 2760 CB LEU B 171 4.295 12. .058 0. .182 1, .00 14. .57 C

ANISOU 2760 CB LEU B 171 1616 2154 1764 -174 -66 -403 C

ATOM 2761 CG LEU B 171 5.091 12. .723 1. .328 1, .00 16. .32 C ANISOU 2761 CG LEU B 171 1655 2314 2230 -89 -778 -37 C

ATOM 2762 CD1 . LEU B 171 6.358 11. .942 1, .672 1, .00 17 , .23 C

ANISOU 2762 CD1 . LEU B 171 1939 2323 2282 371 - 225 296 C

ATOM 2763 CD2 : LEU B 171 5.422 14. .186 1, .011 1, .00 17 , .17 C

ANISOU 2763 CD2 : LEU B 171 1729 2364 2430 -337 45 -194 C

ATOM 2764 N AMET B 172 2.313 12. .351 -2. .375 0. .50 15. .04 N

ANISOU 2764 N AMET B 172 1883 2600 1231 409 249 -635 N

ATOM 2765 CA AMET B 172 1.782 11. .674 -3. .553 0. .50 15. .42 C

ANISOU 2765 CA AMET B 172 1833 2520 1505 417 40 -715 C

ATOM 2766 C AMET B 172 2.904 10. .988 -4. .336 0. .50 16. .74 C

ANISOU 2766 C AMET B 172 1996 2289 2073 508 171 -741 C

ATOM 2767 O AMET B 172 3.898 11. .628 -4. .712 0. .50 16. .14 O

ANISOU 2767 O AMET B 172 1799 2148 2184 320 - 247 -854 O

ATOM 2768 CB AMET B 172 1.068 12. .674 -4. .456 0. .50 15. .88 C

ANISOU 2768 CB AMET B 172 1789 2411 1833 425 25 -654 C

ATOM 2769 CG AMET B 172 0.355 12. ,031 -5. .634 0. .50 15. .65 c

ANISOU 2769 CG AMET B 172 1761 2355 1829 212 -46 -431 c

ATOM 2770 SD AMET B 172 -0.429 13. ,278 -6. .666 0. .50 16. .41 s

ANISOU 2770 SD AMET B 172 1437 2581 2216 751 - 451 -856 s

ATOM 2771 CE AMET B 172 -1.580 14. ,021 -5. .511 0. .50 17. .01 c

ANISOU 2771 CE AMET B 172 1379 2688 2396 594 - 125 -663 c

ATOM 2772 N BMET B 172 2.265 12. .359 -2. .379 0. .50 15. .31 N

ANISOU 2772 N BMET B 172 1955 2646 1216 469 312 -657 N

ATOM 2773 CA BMET B 172 1.733 11. .644 -3. .548 0. .50 16. .06 C

ANISOU 2773 CA BMET B 172 1912 2655 1536 416 77 -746 C

ATOM 2774 C BMET B 172 2.867 10. .994 -4. .351 0. .50 16. .96 C

ANISOU 2774 C BMET B 172 2030 2314 2099 515 184 -731 C

ATOM 2775 O BMET B 172 3.836 11. .662 -4. .744 0. .50 16. .54 O

ANISOU 2775 O BMET B 172 1825 2220 2240 340 - 208 -796 0

ATOM 2776 CB BMET B 172 0.898 12. .570 -4. .444 0. .50 17. .75 c

ANISOU 2776 CB BMET B 172 2090 2709 1943 576 137 -592 c

ATOM 2777 CG BMET B 172 0.145 11. .855 -5. .568 0. .50 21. .54 c

ANISOU 2777 CG BMET B 172 2925 3253 2004 586 -66 -875 c

ATOM 2778 SD BMET B 172 -1.105 10. ,661 -5. .020 0. .50 30. .41 s

ANISOU 2778 SD BMET B 172 3288 4315 3950 256 261 -754 s

ATOM 2779 CE BMET B 172 -2.612 11. ,637 -5. .019 0. .50 30. .64 c

ANISOU 2779 CE BMET B 172 3791 4850 3001 870 - 266 - 1075 c

ATOM 2780 N GLY B 173 2.735 9. .689 -4. .574 1. .00 16. .15 N

ANISOU 2780 N GLY B 173 1695 2498 1943 384 39 - 1299 N

ATOM 2781 CA GLY B 173 3.693 8. .904 -5. .350 1. .00 15. .81 C

ANISOU 2781 CA GLY B 173 1437 2603 1967 432 78 - 1062 C

ATOM 2782 C GLY B 173 3.400 8. .945 -6. .842 1. .00 17. .96 C

ANISOU 2782 C GLY B 173 1871 2950 2003 264 6 - 1057 C

ATOM 2783 O GLY B 173 2.522 9. .701 -7. .300 1. .00 18. .17 0

ANISOU 2783 O GLY B 173 2339 2423 2142 348 297 -990 0

ATOM 2784 N SER B 174 4.137 8. .135 -7. .599 1. .00 17. .83 N

ANISOU 2784 N SER B 174 1835 2607 2330 51 228 - 1022 N

ATOM 2785 CA SER B 174 4.025 8. .119 -9. .062 1. .00 18. .93 C

ANISOU 2785 CA SER B 174 1731 3062 2399 5 13 - 1082 C

ATOM 2786 C SER B 174 3.170 6. .967 -9. .618 1. .00 19. .26 C

ANISOU 2786 C SER B 174 1835 2667 2815 -106 -2 -640 C

ATOM 2787 O SER B 174 3.061 6. ,808 -10. .840 1. .00 21. .32 O

ANISOU 2787 O SER B 174 1816 3537 2746 378 431 -898 O

ATOM 2788 CB SER B 174 5.427 8. .118 -9. .711 1. .00 17. .73 C

ANISOU 2788 CB SER B 174 1766 2213 2757 -255 189 - 1112 c

ATOM 2789 OG SER B 174 6.074 9. .373 -9. .517 1. .00 15. .39 0

ANISOU 2789 OG SER B 174 1416 1914 2515 5 -67 -607 0

ATOM 2790 N ASN B 175 2.578 6. .165 -8. .733 1. .00 18. .59 N

ANISOU 2790 N ASN B 175 1665 2777 2620 -119 - 301 -583 N

ATOM 2791 CA ASN B 175 1.811 4. .988 -9. .145 1. .00 18. .57 C

ANISOU 2791 CA ASN B 175 1129 3200 2725 -533 116 -508 C ATOM 2792 C ASN B 175 0.391 5..076 -8..590 1..00 22..46 C

ANISOU 2792 C ASN B 175 1544 4057 2931 -367 614 -733 C

ATOM 2793 O ASN B 175 -0.183 4. ,065 -8. .175 1. .00 21. .22 O

ANISOU 2793 O ASN B 175 1314 3975 2771 -363 -2 -767 O

ATOM 2794 CB ASN B 175 2.508 3. .698 -8. .679 1. .00 20. .16 C

ANISOU 2794 CB ASN B 175 1847 3000 2810 -813 -68 -590 C

ATOM 2795 CG ASN B 175 1.991 2. .448 -9. .382 1. .00 21. .06 C

ANISOU 2795 CG ASN B 175 2204 3186 2609 -775 402 -858 C

ATOM 2796 OD1 ASN B 175 1.824 1. .388 -8. .766 1. .00 27. .67 O

ANISOU 2796 OD1 ASN B 175 2597 3263 4653 -1273 628 -578 O

ATOM 2797 ND2 ASN B 175 1.742 2. .561 -10. .666 1. .00 21. .07 N

ANISOU 2797 ND2 ASN B 175 1833 3718 2453 -640 459 - 1337 N

ATOM 2798 N GLU B 176 -0.162 6. ,292 -8. .576 1. .00 21. .97 N

ANISOU 2798 N GLU B 176 1721 3914 2710 -386 487 -543 N

ATOM 2799 CA GLU B 176 -1.560 6. ,547 -8. .130 1. .00 25. .29 C

ANISOU 2799 CA GLU B 176 1766 4969 2871 124 208 -776 C

ATOM 2800 C GLU B 176 -1.813 6. ,307 -6. .641 1. .00 25. .28 C

ANISOU 2800 C GLU B 176 1780 4898 2927 -417 -85 -563 C

ATOM 2801 O GLU B 176 -2.963 6. ,183 -6. .216 1. .00 26. .31 O

ANISOU 2801 O GLU B 176 1924 4996 3074 -968 -19 - 1107 O

ATOM 2802 CB GLU B 176 -2.565 5. ,724 -8. .941 1. .00 26. .15 C

ANISOU 2802 CB GLU B 176 1182 5394 3358 -9 422 -732 C

ATOM 2803 CG GLU B 176 -2.474 5. ,871 -10. .443 1. .00 30. .36 C

ANISOU 2803 CG GLU B 176 2084 6189 3261 56 794 -977 C

ATOM 2804 CD GLU B 176 -3.381 4. ,888 -11. .148 1. .00 38. .62 C

ANISOU 2804 CD GLU B 176 2825 7643 4204 -134 -292 - 1390 C

ATOM 2805 OE1 GLU B 176 -4.607 4. ,954 -10. .925 1. .00 40. .84 O

ANISOU 2805 OE1 GLU B 176 2570 9104 3843 -475 -1108 - 1099 O

ATOM 2806 OE2 GLU B 176 -2.872 4. ,035 -11. .905 1. .00 37. .78 O

ANISOU 2806 OE2 GLU B 176 2614 7365 4372 191 -145 -781 O

ATOM 2807 N GLY B 177 -0.745 6. ,242 -5. .848 1. .00 21. .07 N

ANISOU 2807 N GLY B 177 1847 3470 2688 -304 -149 -691 N

ATOM 2808 CA GLY B 177 -0.897 6. ,037 -4. .414 1. .00 18. .80 C

ANISOU 2808 CA GLY B 177 1288 3135 2718 -1005 7 -645 C

ATOM 2809 C GLY B 177 -0.398 7. ,219 -3. .609 1. .00 20. .92 C

ANISOU 2809 C GLY B 177 2328 2625 2992 -592 -164 -658 C

ATOM 2810 O GLY B 177 0.147 8. ,167 -4. .165 1. .00 23. .09 O

ANISOU 2810 O GLY B 177 3195 2781 2794 -1203 266 - 1102 O

ATOM 2811 N GLU B 178 -0.579 7. ,150 -2. .295 1. .00 19. .71 N

ANISOU 2811 N GLU B 178 2204 2254 3031 -216 89 -781 N

ATOM 2812 CA GLU B 178 -0.079 8. ,168 -1. .379 1. .00 18. .53 C

ANISOU 2812 CA GLU B 178 1904 2962 2172 44 -210 -711 C

ATOM 2813 C GLU B 178 0.772 7. .529 -0. .290 1. .00 17. .25 C

ANISOU 2813 C GLU B 178 1642 2561 2348 -19 130 -386 C

ATOM 2814 O GLU B 178 0.618 6. .332 0, .007 1, .00 19, .52 O

ANISOU 2814 O GLU B 178 2047 2491 2878 -103 -92 -408 O

ATOM 2815 CB GLU B 178 -1.246 8. ,929 -0. .747 1. .00 24. .26 C

ANISOU 2815 CB GLU B 178 2469 3414 3333 674 -90 -928 C

ATOM 2816 CG GLU B 178 -2.196 9. ,550 -1. .752 1. .00 27. .14 c

ANISOU 2816 CG GLU B 178 1952 4455 3905 288 -694 - 1149 c

ATOM 2817 CD GLU B 178 -3.487 10. ,021 -1. .110 1. .00 30. .10 c

ANISOU 2817 CD GLU B 178 2186 5398 3850 512 -425 - 1024 c

ATOM 2818 OE1 GLU B 178 -3.647 9. ,839 0. .108 1. .00 28. .25 0

ANISOU 2818 OE1 GLU B 178 1295 6188 3248 975 -628 - 2637 0

ATOM 2819 OE2 GLU B 178 -4.353 10. ,556 -1. .833 1. .00 39. .37 0

ANISOU 2819 OE2 GLU B 178 1856 5982 7118 1197 -551 -288 0

ATOM 2820 N PHE B 179 1.658 8. .330 0, .307 1, .00 15, .48 N

ANISOU 2820 N PHE B 179 1393 2820 1668 133 51 -322 N

ATOM 2821 CA PHE B 179 2.493 7. .865 1, .419 1, .00 14, .57 C

ANISOU 2821 CA PHE B 179 1177 2756 1602 72 241 -167 C

ATOM 2822 C PHE B 179 2.028 8. .605 2, .664 1, .00 16, .42 C ANISOU 2822 C PHE B 179 1711 2526 2001 -160 488 -414 C

ATOM 2823 O PHE B 179 1.856 9. .830 2. .638 1, .00 17. .20 O

ANISOU 2823 O PHE B 179 1848 2527 2158 166 752 -478 O

ATOM 2824 CB PHE B 179 3.981 8. .099 1. .142 1, .00 13. .40 C

ANISOU 2824 CB PHE B 179 1292 2117 1680 48 527 -258 C

ATOM 2825 CG PHE B 179 4.423 7. .665 -0. ,245 1. .00 15. , 15 C

ANISOU 2825 CG PHE B 179 1564 2525 1666 87 460 -329 C

ATOM 2826 CD1 PHE B 179 4.071 6. .413 -0. ,747 1. .00 16. , 33 C

ANISOU 2826 CD1 PHE B 179 1835 2237 2129 469 200 -322 C

ATOM 2827 CD2 PHE B 179 5.184 8. .519 -1. ,053 1. .00 16. , 32 C

ANISOU 2827 CD2 PHE B 179 1762 2352 2087 104 716 -337 C

ATOM 2828 CE1 PHE B 179 4.463 6. .017 -2. ,032 1. .00 19. , 23 C

ANISOU 2828 CE1 PHE B 179 1726 2887 2693 236 919 -605 C

ATOM 2829 CE2 PHE B 179 5.583 8. .132 -2. ,324 1. .00 16. , 93 C

ANISOU 2829 CE2 PHE B 179 1527 2497 2407 305 647 -750 C

ATOM 2830 CZ PHE B 179 5.228 6. .873 -2. ,819 1. .00 18. , 82 C

ANISOU 2830 CZ PHE B 179 2214 2338 2595 121 459 -491 C

ATOM 2831 N LYS B 180 1.787 7. .860 3. .740 1, .00 18. .67 N

ANISOU 2831 N LYS B 180 2427 2757 1907 262 504 -249 N

ATOM 2832 CA LYS B 180 1.154 8. .426 4. .950 1, .00 17. .94 C

ANISOU 2832 CA LYS B 180 1590 2869 2356 -156 616 -637 C

ATOM 2833 C LYS B 180 1.910 8. ,066 6. ,211 1. .00 19. ,16 C

ANISOU 2833 C LYS B 180 2276 2536 2467 -7 539 -379 C

ATOM 2834 O LYS B 180 2.802 7. .208 6. .191 1, .00 18. .71 O

ANISOU 2834 O LYS B 180 2236 2663 2207 99 450 -292 O

ATOM 2835 CB LYS B 180 -0.288 7. ,915 5. ,112 1. .00 19. , 75 C

ANISOU 2835 CB LYS B 180 1744 3025 2735 -398 366 4 C

ATOM 2836 CG LYS B 180 -1.215 8. ,238 3. ,957 1. .00 21. , 74 c

ANISOU 2836 CG LYS B 180 1691 3743 2824 -669 -46 -734 c

ATOM 2837 CD LYS B 180 -2.625 7. ,832 4. ,325 1. .00 27. ,81 c

ANISOU 2837 CD LYS B 180 1803 4684 4078 -391 739 -702 c

ATOM 2838 CE LYS B 180 -3.443 7. ,613 3. ,079 1. .00 31. , 88 c

ANISOU 2838 CE LYS B 180 2411 4871 4828 -440 229 - 1020 c

ATOM 2839 NZ LYS B 180 -4.735 7. ,001 3. ,480 1. .00 41. ,41 N

ANISOU 2839 NZ LYS B 180 5190 5012 5531 -1800 1945 545 N

ATOM 2840 N ALA B 181 1.532 8. .724 7. .307 1, .00 20. .94 N

ANISOU 2840 N ALA B 181 2888 2788 2279 0 583 -375 N

ATOM 2841 CA ALA B 181 2.062 8. .434 8. .628 1, .00 19. .82 C

ANISOU 2841 CA ALA B 181 2632 2576 2321 5 710 -388 C

ATOM 2842 C ALA B 181 1.657 7. .032 9. .069 1, .00 20. .98 C

ANISOU 2842 C ALA B 181 2448 2932 2590 -222 1032 -42 C

ATOM 2843 O ALA B 181 2.447 6. .325 9. .687 1, .00 22. .46 O

ANISOU 2843 O ALA B 181 3189 2518 2826 219 1056 -387 O

ATOM 2844 CB ALA B 181 1.558 9. .467 9. .631 1, .00 21. .91 C

ANISOU 2844 CB ALA B 181 2333 3245 2746 -187 1135 -778 C

ATOM 2845 N GLU B 182 0.422 6. .641 8. .738 1, .00 25. .08 N

ANISOU 2845 N GLU B 182 3030 3704 2793 -955 830 -207 N

ATOM 2846 CA GLU B 182 -0.172 5. ,385 9. ,221 1. .00 23. , 27 C

ANISOU 2846 CA GLU B 182 2912 3472 2458 -597 1326 -405 C

ATOM 2847 C GLU B 182 -0.913 4. ,652 8. ,114 1. .00 23. , 99 C

ANISOU 2847 C GLU B 182 2383 3725 3005 -897 1624 -758 C

ATOM 2848 O GLU B 182 -0.903 5. ,081 6. ,959 1. .00 27. , 69 O

ANISOU 2848 O GLU B 182 2911 4493 3114 -876 362 -731 O

ATOM 2849 CB GLU B 182 -1.121 5. ,648 10. ,402 1. .00 27. , 33 C

ANISOU 2849 CB GLU B 182 3533 4458 2393 -631 1611 -286 C

ATOM 2850 CG GLU B 182 -0.423 6. ,248 11. ,614 1. .00 30. ,76 c

ANISOU 2850 CG GLU B 182 3954 4905 2828 -656 751 152 c

ATOM 2851 CD GLU B 182 -1.358 6. ,662 12. ,737 1. .00 36. , 61 c

ANISOU 2851 CD GLU B 182 5027 6009 2872 -421 1271 354 c

ATOM 2852 OE1 GLU B 182 -2.368 7. ,359 12. ,485 1. .00 42. , 23 0

ANISOU 2852 OE1 GLU B 182 4921 7498 3626 -29 1064 344 0 ATOM 2853 OE2 GLU B 182 -1.050 6.,314 13.,892 1..00 39..55 O

ANISOU 2853 OE2 GLU B 182 6863 5757 2405 -1755 1581 460 O

ATOM 2854 N GLY B 183 -1.547 3. ,541 8. ,480 1. .00 26. .90 N

ANISOU 2854 N GLY B 183 3178 4083 2956 -1354 1545 -685 N

ATOM 2855 CA GLY B 183 -2.313 2. ,736 7. ,546 1. .00 30. .83 C

ANISOU 2855 CA GLY B 183 4486 3432 3796 -1080 1135 - 1213 C

ATOM 2856 C GLY B 183 -1.449 1. ,657 6. ,941 1. .00 28. .79 C

ANISOU 2856 C GLY B 183 3430 3435 4074 -954 969 -576 C

ATOM 2857 O GLY B 183 -0.478 1. ,210 7. ,556 1. .00 33. .89 O

ANISOU 2857 O GLY B 183 4710 3955 4210 -49 794 -382 O

ATOM 2858 N ASN B 184 -1.806 1. ,256 5. ,725 1. .00 32. .08 N

ANISOU 2858 N ASN B 184 4134 3687 4367 -1235 1070 - 1319 N

ATOM 2859 CA ASN B 184 -1.115 0. ,201 4. ,993 1. .00 32. .81 C

ANISOU 2859 CA ASN B 184 4863 4109 3494 -529 1436 -540 C

ATOM 2860 C ASN B 184 0.400 0. .403 5. .049 1, .00 33, .03 C

ANISOU 2860 C ASN B 184 4976 3636 3936 -810 524 -337 C

ATOM 2861 O ASN B 184 0.921 1. .382 4. .506 1. .00 29. .75 O

ANISOU 2861 O ASN B 184 3673 4129 3501 -800 971 -396 O

ATOM 2862 CB ASN B 184 -1.608 0. ,192 3. ,541 1. .00 33. .22 C

ANISOU 2862 CB ASN B 184 5050 3169 4403 -785 -58 - 1187 C

ATOM 2863 CG ASN B 184 -1.123 -1. ,008 2. ,752 1. .00 37. .62 c

ANISOU 2863 CG ASN B 184 6363 3105 4823 -408 878 -795 c

ATOM 2864 OD1 ASN B 184 -0.209 -1. ,729 3. ,165 1. .00 39. .80 0

ANISOU 2864 OD1 ASN B 184 6740 3771 4609 -230 1213 206 0

ATOM 2865 ND2 ASN B 184 -1.739 -1. ,227 1. ,593 1. .00 42. .04 N

ANISOU 2865 ND2 ASN B 184 7112 4006 4855 -761 632 -564 N

ATOM 2866 N SER B 185 1.092 -0. ,535 5. ,700 1. .00 35. .22 N

ANISOU 2866 N SER B 185 5603 3957 3819 -712 664 -60 N

ATOM 2867 CA SER B 185 2.528 -0. ,411 5. ,990 1. .00 33. .70 C

ANISOU 2867 CA SER B 185 5065 4254 3484 -193 1557 7 C

ATOM 2868 C SER B 185 3.416 -0. ,378 4. ,745 1. .00 29. .75 C

ANISOU 2868 C SER B 185 4362 3595 3343 -209 1249 -343 C

ATOM 2869 O SER B 185 4.547 0. .104 4. .816 1, .00 35, .08 O

ANISOU 2869 O SER B 185 4657 4378 4294 -191 617 -860 O

ATOM 2870 CB SER B 185 3.001 -1. ,510 6. ,954 1. .00 36. .78 C

ANISOU 2870 CB SER B 185 5735 3644 4594 -204 1501 91 C

ATOM 2871 OG SER B 185 2.839 -2. ,801 6. ,389 1. .00 41. .63 O

ANISOU 2871 OG SER B 185 7126 3376 5316 245 1388 252 O

ATOM 2872 N LYS B 186 2.903 -0. ,875 3. ,618 1. .00 29. .93 N

ANISOU 2872 N LYS B 186 4603 3550 3219 -390 1169 -349 N

ATOM 2873 CA LYS B 186 3.610 -0. ,796 2. ,331 1. .00 27. .51 C

ANISOU 2873 CA LYS B 186 4032 3393 3027 -521 703 -42 C

ATOM 2874 C LYS B 186 3.788 0. .648 1. .886 1, .00 26, .43 C

ANISOU 2874 C LYS B 186 3608 3086 3345 -434 1045 -433 C

ATOM 2875 O LYS B 186 4.718 0. .964 1. .124 1, .00 23, .88 O

ANISOU 2875 O LYS B 186 2552 3346 3175 -237 594 -441 O

ATOM 2876 CB LYS B 186 2.835 -1. ,520 1. ,225 1. .00 28. .75 C

ANISOU 2876 CB LYS B 186 4254 3006 3662 -648 641 -394 C

ATOM 2877 CG LYS B 186 2.792 -3. ,031 1. ,314 1. .00 30. .44 c

ANISOU 2877 CG LYS B 186 4222 2964 4378 -230 473 -760 c

ATOM 2878 CD LYS B 186 1.625 -3. ,530 0. ,462 1. .00 33. .50 c

ANISOU 2878 CD LYS B 186 4086 3869 4773 -383 107 -152 c

ATOM 2879 CE LYS B 186 1.007 -4. ,817 0. ,981 1. .00 36. .45 c

ANISOU 2879 CE LYS B 186 5145 3169 5534 82 330 -164 c

ATOM 2880 NZ LYS B 186 1.917 -5. ,979 0. ,764 1. .00 42. .89 N

ANISOU 2880 NZ LYS B 186 4957 4218 7118 568 208 -251 N

ATOM 2881 N PHE B 187 2.887 1. .516 2. .354 1, .00 25, .67 N

ANISOU 2881 N PHE B 187 2917 3015 3820 -363 399 -283 N

ATOM 2882 CA PHE B 187 2.794 2. .893 1. .858 1, .00 21, .91 C

ANISOU 2882 CA PHE B 187 2416 2987 2919 -274 -654 -459 C

ATOM 2883 C PHE B 187 3.071 3. .944 2. .934 1, .00 22, .23 C ANISOU 2883 C PHE B 187 2744 2689 3013 -134 -35 -549 C

ATOM 2884 O PHE B 187 2.926 5. .132 2. .685 1. .00 22. .95 O

ANISOU 2884 O PHE B 187 3097 2934 2688 106 -43 -480 O

ATOM 2885 CB PHE B 187 1.415 3. .136 1. .215 1. .00 23. .59 C

ANISOU 2885 CB PHE B 187 2594 3544 2824 -367 -809 -88 C

ATOM 2886 CG PHE B 187 1.208 2. .390 -0. , 080 1. ,00 27. , 00 C

ANISOU 2886 CG PHE B 187 2421 4578 3258 -283 -793 -794 C

ATOM 2887 CD1 PHE B 187 1.561 2. ,968 -1. ,298 1. ,00 29. , 55 C

ANISOU 2887 CD1 PHE B 187 2644 5042 3542 -160 -269 -754 C

ATOM 2888 CD2 PHE B 187 0.658 1. .105 -0. , 084 1. ,00 32. , 87 C

ANISOU 2888 CD2 PHE B 187 3913 4455 4119 -475 -979 -505 C

ATOM 2889 CE1 PHE B 187 1.378 2. .279 -2. ,491 1. ,00 31. ,41 C

ANISOU 2889 CE1 PHE B 187 1748 6417 3769 -327 -860 - 1172 C

ATOM 2890 CE2 PHE B 187 0.475 0. .412 -1. , 274 1. ,00 41. , 03 C

ANISOU 2890 CE2 PHE B 187 5349 6342 3895 -246 -741 -968 C

ATOM 2891 CZ PHE B 187 0.837 1. .001 -2. , 479 1. ,00 37. ,11 C

ANISOU 2891 CZ PHE B 187 3814 5821 4462 -111 12 - 1096 C

ATOM 2892 N THR B 188 3.490 3. .526 4. .122 1. .00 22. .82 N

ANISOU 2892 N THR B 188 2698 3137 2836 -290 377 -505 N

ATOM 2893 CA THR B 188 3.854 4. .507 5. .135 1. .00 20. .06 C

ANISOU 2893 CA THR B 188 2467 2373 2782 -458 648 -207 C

ATOM 2894 C THR B 188 5.237 5. .052 4. .851 1. .00 18. .50 C

ANISOU 2894 C THR B 188 2049 2216 2763 -173 281 -302 C

ATOM 2895 O THR B 188 6.111 4. .341 4. .367 1. .00 20. .84 O

ANISOU 2895 O THR B 188 2449 2939 2529 77 669 -111 O

ATOM 2896 CB THR B 188 3.822 3. .951 6. .564 1. .00 18. .41 C

ANISOU 2896 CB THR B 188 2096 2273 2625 -189 532 -428 C

ATOM 2897 OG1 THR B 188 4.550 2. .723 6. .619 1. .00 22. .88 0

ANISOU 2897 OG1 THR B 188 3615 2054 3022 47 402 188 0

ATOM 2898 CG2 THR B 188 2.387 3. .733 7. .006 1. .00 19. .57 c

ANISOU 2898 CG2 THR B 188 2216 2461 2758 27 916 -225 c

ATOM 2899 N TYR B 189 5.431 6. .327 5. .126 1. .00 17. .32 N

ANISOU 2899 N TYR B 189 1924 2297 2360 -474 680 -177 N

ATOM 2900 CA TYR B 189 6.770 6. .887 5. .043 1. .00 15. .67 C

ANISOU 2900 CA TYR B 189 1913 1760 2280 -405 490 71 C

ATOM 2901 C TYR B 189 7.460 6. .734 6. .400 1. .00 18. .68 C

ANISOU 2901 C TYR B 189 2398 2479 2219 -207 525 -182 C

ATOM 2902 O TYR B 189 6.860 6. .241 7. .361 1. .00 18. .40 O

ANISOU 2902 O TYR B 189 2390 2454 2147 112 458 -85 O

ATOM 2903 CB TYR B 189 6.713 8. .347 4. .573 1. .00 16. .23 c

ANISOU 2903 CB TYR B 189 2332 1859 1974 -162 555 118 c

ATOM 2904 CG TYR B 189 5.773 9. ,255 5. , 348 1. ,00 17. , 65 c

ANISOU 2904 CG TYR B 189 2037 2425 2241 212 59 -188 c

ATOM 2905 CD1 TYR B 189 5.951 9. .480 6. .727 1. .00 15. .67 c

ANISOU 2905 CD1 TYR B 189 1356 2359 2237 -56 222 -287 c

ATOM 2906 CD2 TYR B 189 4.734 9. .933 4. .694 1. .00 15. .85 c

ANISOU 2906 CD2 TYR B 189 1778 2390 1853 -37 176 -86 c

ATOM 2907 CE1 TYR B 189 5.111 10. .336 7. .423 1. .00 17. .61 c

ANISOU 2907 CE1 TYR B 189 1840 2560 2289 412 28 -252 c

ATOM 2908 CE2 TYR B 189 3.888 10. .793 5. .390 1. .00 15. .34 c

ANISOU 2908 CE2 TYR B 189 1672 2338 1817 18 -180 -290 c

ATOM 2909 CZ TYR B 189 4.072 10. .982 6. .749 1. .00 15. .72 c

ANISOU 2909 CZ TYR B 189 1679 2553 1740 -29 -73 -110 c

ATOM 2910 OH TYR B 189 3.252 11. .841 7. .459 1. .00 16. .73 0

ANISOU 2910 OH TYR B 189 1654 2738 1962 -60 -84 -214 0

ATOM 2911 N THR B 190 8.731 7. .098 6. .477 1. .00 18. .75 N

ANISOU 2911 N THR B 190 2366 2382 2374 -2 243 -729 N

ATOM 2912 CA THR B 190 9.403 7. .163 7. .769 1. .00 21. .59 c

ANISOU 2912 CA THR B 190 2988 2848 2366 706 169 -568 c

ATOM 2913 C THR B 190 9.851 8. .593 7. .982 1. .00 20. .25 c

ANISOU 2913 C THR B 190 2507 3130 2054 340 195 -619 c ATOM 2914 O THR B 190 10.031 9..351 7..020 1..00 21..12 O

ANISOU 2914 O THR B 190 2881 2905 2239 38 207 -596 O

ATOM 2915 CB THR B 190 10.611 6. ,200 7. ,897 1. ,00 25. , 32 C

ANISOU 2915 CB THR B 190 2997 2823 3800 823 623 - 1122 C

ATOM 2916 OG1 THR B 190 11.687 6. .668 7. .085 1. .00 33. .70 O

ANISOU 2916 OG1 THR B 190 2957 4186 5661 890 925 -370 O

ATOM 2917 CG2 THR B 190 10.238 4. .785 7. .513 1. .00 22. .18 C

ANISOU 2917 CG2 THR B 190 2895 2385 3145 1302 456 - 1025 C

ATOM 2918 N VAL B 191 10.009 8. .963 9. .248 1. .00 19. .41 N

ANISOU 2918 N VAL B 191 2307 2868 2197 796 -125 -680 N

ATOM 2919 CA VAL B 191 10.367 10. .322 9. .609 1. .00 19. .66 C

ANISOU 2919 CA VAL B 191 2609 2935 1925 740 -102 -755 C

ATOM 2920 C VAL B 191 11.778 10. .297 10. .173 1. .00 18. .34 C

ANISOU 2920 C VAL B 191 2676 2412 1880 756 -122 -45 C

ATOM 2921 O VAL B 191 12.045 9. ,600 11. ,152 1. ,00 23. , 03 O

ANISOU 2921 O VAL B 191 3284 3184 2279 1130 -311 406 O

ATOM 2922 CB VAL B 191 9.325 10. .907 10. .588 1. .00 20. .16 C

ANISOU 2922 CB VAL B 191 2363 2808 2488 1079 -236 -836 C

ATOM 2923 CGI VAL B 191 9.718 12. .307 11. .042 1. .00 21. .18 C

ANISOU 2923 CGI VAL B 191 2704 2927 2417 771 -165 -823 c

ATOM 2924 CG2 VAL B 191 7.954 10. .920 9. .903 1. .00 22. .20 c

ANISOU 2924 CG2 VAL B 191 2176 3486 2771 873 -30 -629 c

ATOM 2925 N LEU B 192 12.681 11. .026 9. .518 1. .00 19. .59 N

ANISOU 2925 N LEU B 192 2328 2607 2507 628 129 -263 N

ATOM 2926 CA LEU B 192 14.099 11. .039 9. .898 1. .00 21. .76 C

ANISOU 2926 CA LEU B 192 2583 3314 2370 887 -83 271 C

ATOM 2927 C LEU B 192 14.418 12. ,022 11. ,021 1. ,00 22. , 80 C

ANISOU 2927 C LEU B 192 2844 3606 2213 993 -638 368 C

ATOM 2928 O LEU B 192 15.286 11. .754 11. .849 1. .00 27. .24 O

ANISOU 2928 O LEU B 192 3686 3966 2697 1762 -1087 459 O

ATOM 2929 CB LEU B 192 14.996 11. .301 8. .673 1. .00 22. .67 c

ANISOU 2929 CB LEU B 192 2801 3438 2375 311 -59 237 c

ATOM 2930 CG LEU B 192 14.896 10. .314 7. .497 1. .00 25. .80 c

ANISOU 2930 CG LEU B 192 3814 3323 2666 732 333 -16 c

ATOM 2931 CD1 LEU B 192 15.998 10. .601 6. .481 1. .00 24. .00 c

ANISOU 2931 CD1 LEU B 192 2890 3297 2929 464 -105 -484 c

ATOM 2932 CD2 LEU B 192 14.948 8. .856 7. .951 1. .00 23. .99 c

ANISOU 2932 CD2 LEU B 192 3028 2855 3230 -348 497 -558 c

ATOM 2933 N GLU B 193 13.745 13. .169 11. .023 1. .00 23. .17 N

ANISOU 2933 N GLU B 193 2433 3574 2797 818 -228 -145 N

ATOM 2934 CA GLU B 193 13.830 14. .146 12. .109 1. .00 23. .01 C

ANISOU 2934 CA GLU B 193 2062 4073 2607 1207 -20 -266 C

ATOM 2935 C GLU B 193 12.537 14. .944 12. .094 1. .00 22. .84 C

ANISOU 2935 C GLU B 193 2096 3951 2630 1161 -227 -522 C

ATOM 2936 O GLU B 193 11.934 15. .170 11. .027 1. .00 21. .48 0

ANISOU 2936 O GLU B 193 2284 3451 2424 1197 -209 -327 0

ATOM 2937 CB GLU B 193 15.048 15. .074 11. .979 1. .00 29. .35 c

ANISOU 2937 CB GLU B 193 2968 4409 3773 569 -688 -135 c

ATOM 2938 CG GLU B 193 15.036 16. .000 10. .774 1. .00 33. .32 c

ANISOU 2938 CG GLU B 193 3109 5196 4355 486 -170 512 c

ATOM 2939 CD GLU B 193 16.329 16. .780 10. .591 1. .00 37. .94 c

ANISOU 2939 CD GLU B 193 2561 6158 5696 464 -855 -115 c

ATOM 2940 OE1 GLU B 193 17.315 16. .195 10. .088 1. .00 38. .32 0

ANISOU 2940 OE1 GLU B 193 2824 5436 6298 737 -206 921 0

ATOM 2941 OE2 GLU B 193 16.354 17. ,990 10. ,926 1. ,00 38. , 97 0

ANISOU 2941 OE2 GLU B 193 3751 6002 5050 -536 -935 146 0

ATOM 2942 N ASP B 194 12.102 15. .374 13. .265 1. .00 20. .59 N

ANISOU 2942 N ASP B 194 2049 3496 2276 805 -367 -397 N

ATOM 2943 CA ASP B 194 10.809 16. .046 13. .330 1. .00 19. .60 C

ANISOU 2943 CA ASP B 194 1682 3107 2656 436 -223 -561 C

ATOM 2944 C ASP B 194 10.890 17. .260 14. .252 1. .00 21. .18 c ANISOU 2944 C ASP B 194 2469 3112 2465 153 -217 -430 C

ATOM 2945 O ASP B 194 10.762 17. .138 15. .471 1. .00 23. .33 O

ANISOU 2945 O ASP B 194 3126 3473 2263 229 -336 -616 O

ATOM 2946 CB ASP B 194 9.707 15. .048 13. .767 1. .00 22. .35 C

ANISOU 2946 CB ASP B 194 2456 3014 3020 261 -308 -254 C

ATOM 2947 CG ASP B 194 8.299 15. .652 13. .735 1. .00 20. .95 C

ANISOU 2947 CG ASP B 194 2507 2986 2465 277 -198 -640 C

ATOM 2948 OD1 ASP B 194 8.127 16. .805 13. .280 1. .00 21. .89 O

ANISOU 2948 OD1 ASP B 194 2325 3299 2693 343 -93 -48 O

ATOM 2949 OD2 ASP B 194 7.353 14. .963 14. .174 1. .00 22. .14 O

ANISOU 2949 OD2 ASP B 194 2274 3091 3046 310 -321 -657 O

ATOM 2950 N GLY B 195 11.101 18. .433 13. .657 1. .00 19. .75 N

ANISOU 2950 N GLY B 195 1989 2937 2576 254 -342 -475 N

ATOM 2951 CA GLY B 195 11.195 19. .670 14. .419 1. .00 19. .87 C

ANISOU 2951 CA GLY B 195 1918 3082 2547 212 -185 -616 C

ATOM 2952 C GLY B 195 9.947 20. .527 14. .395 1. .00 21. .31 C

ANISOU 2952 C GLY B 195 2371 3035 2690 403 -527 -814 C

ATOM 2953 O GLY B 195 9.968 21. .640 14. .927 1. .00 19. .14 O

ANISOU 2953 O GLY B 195 2132 2996 2143 -105 -348 -782 O

ATOM 2954 N CYS B 196 8.867 20. .009 13. .789 1. .00 19. .91 N

ANISOU 2954 N CYS B 196 2094 2831 2637 440 -338 -632 N

ATOM 2955 CA CYS B 196 7.631 20. ,764 13. ,551 1. ,00 16. , 02 C

ANISOU 2955 CA CYS B 196 1787 2913 1386 113 -484 -304 C

ATOM 2956 C CYS B 196 6.509 20. .512 14. .571 1. .00 17. .61 C

ANISOU 2956 C CYS B 196 2202 2671 1817 329 -99 -439 C

ATOM 2957 O CYS B 196 5.364 20. .920 14. .355 1. .00 20. .46 O

ANISOU 2957 O CYS B 196 2165 3241 2366 657 176 -474 O

ATOM 2958 CB CYS B 196 7.110 20. .460 12. .131 1. ,00 16. , 27 C

ANISOU 2958 CB CYS B 196 1713 2803 1663 -65 -744 -427 C

ATOM 2959 SG CYS B 196 8.267 21. .015 10. .850 1. .00 18. .50 s

ANISOU 2959 SG CYS B 196 1903 2881 2242 186 -274 -547 s

ATOM 2960 N THR B 197 6.835 19. .856 15. .677 1. .00 17. .76 N

ANISOU 2960 N THR B 197 2764 2355 1628 176 -121 -511 N

ATOM 2961 CA THR B 197 5.799 19. .352 16. .575 1. .00 20. .03 C

ANISOU 2961 CA THR B 197 2855 2629 2124 215 212 -502 C

ATOM 2962 C THR B 197 5.076 20. .407 17. .425 1. .00 21. .11 C

ANISOU 2962 C THR B 197 2767 2700 2552 202 322 -628 C

ATOM 2963 O THR B 197 4.039 20. .104 18. .006 1. .00 22. .19 O

ANISOU 2963 O THR B 197 2396 2880 3155 -39 66 -355 O

ATOM 2964 CB THR B 197 6.330 18. .258 17. .521 1. .00 20. .94 C

ANISOU 2964 CB THR B 197 3079 2597 2279 441 -453 -823 c

ATOM 2965 OG1 THR B 197 7.133 18. .869 18. .532 1. .00 23. .55 0

ANISOU 2965 OG1 THR B 197 3002 2924 3020 -204 -430 - 1026 0

ATOM 2966 CG2 THR B 197 7.145 17. ,196 16. ,762 1. ,00 21. ,49 c

ANISOU 2966 CG2 THR B 197 3295 2772 2097 628 -238 -598 c

ATOM 2967 N LYS B 198 5.602 21. .624 17. .509 1. .00 22. .15 N

ANISOU 2967 N LYS B 198 3006 2948 2461 44 258 -819 N

ATOM 2968 CA LYS B 198 4.910 22. .728 18. .202 1. .00 23. .59 C

ANISOU 2968 CA LYS B 198 3258 2558 3146 -329 296 - 1285 C

ATOM 2969 C LYS B 198 4.771 23. .988 17. .368 1. ,00 23. ,46 C

ANISOU 2969 C LYS B 198 3109 2707 3097 -220 -14 - 1368 C

ATOM 2970 O LYS B 198 5.569 24. .233 16. .498 1. .00 25. .83 O

ANISOU 2970 O LYS B 198 3214 3133 3467 -108 282 - 1347 0

ATOM 2971 CB LYS B 198 5.635 23. .148 19. .480 1. .00 20. .00 c

ATOM 2972 CG LYS B 198 6.317 22. .077 20. .278 1. .00 20. .00 c

ATOM 2973 CD LYS B 198 6.975 22. .667 21. .513 1. .00 20. .00 c

ATOM 2974 CE LYS B 198 6.047 22. .584 22. .716 1. .00 20. .00 c

ATOM 2975 NZ LYS B 198 6.789 22. .573 24. .015 1. .00 20. .00 N

ATOM 2976 N HIS B 199 3.771 24. .805 17. .676 1. .00 23. .05 N

ANISOU 2976 N HIS B 199 2696 3298 2760 -153 221 -947 N

ATOM 2977 CA HIS B 199 3.655 26. .147 17. .113 1. .00 22. .28 C ANISOU 2977 CA HIS B 199 2314 3162 2987 -541 70 - 1143 C

ATOM 2978 C HIS B 199 4.418 27. .051 18. .038 1. .00 21. .32 C

ANISOU 2978 C HIS B 199 2300 3380 2418 -676 194 -974 C

ATOM 2979 O HIS B 199 4.003 27. .283 19. .186 1. .00 23. .60 O

ANISOU 2979 O HIS B 199 2653 4379 1931 -637 -136 -568 O

ATOM 2980 CB HIS B 199 2.198 26. .626 17. .066 1. .00 24. .44 C

ANISOU 2980 CB HIS B 199 2260 4025 2999 -393 -388 -854 C

ATOM 2981 CG HIS B 199 1.308 25. .885 16. .089 1. .00 20. .75 C

ANISOU 2981 CG HIS B 199 1629 3240 3016 332 -360 -899 C

ATOM 2982 ND1 HIS B 199 0.071 26. .346 15. .748 1. .00 23. .46 N

ANISOU 2982 ND1 HIS B 199 1300 3643 3969 293 -289 - 1336 N

ATOM 2983 CD2 HIS B 199 1.482 24. .685 15. .401 1. .00 20. .83 C

ANISOU 2983 CD2 HIS B 199 2132 3193 2589 -59 -477 -882 C

ATOM 2984 CE1 HIS B 199 -0.502 25. ,486 14. , 883 1. ,00 22. , 34 C

ANISOU 2984 CE1 HIS B 199 1700 3487 3301 -101 -169 -844 C

ATOM 2985 NE2 HIS B 199 0.359 24. .469 14. .671 1. .00 21. .08 N

ANISOU 2985 NE2 HIS B 199 1862 3558 2587 38 -301 - 1061 N

ATOM 2986 N THR B 200 5.533 27. .576 17. .557 1. .00 19. .54 N

ANISOU 2986 N THR B 200 1934 2631 2859 -841 -368 -920 N

ATOM 2987 CA THR B 200 6.381 28. .451 18. .384 1. .00 19. .45 C

ANISOU 2987 CA THR B 200 1794 2768 2826 -741 -362 -994 C

ATOM 2988 C THR B 200 6.626 29. .811 17. .764 1. .00 20. .57 C

ANISOU 2988 C THR B 200 2138 2899 2776 -480 -87 -829 C

ATOM 2989 O THR B 200 7.328 30. .627 18. .348 1. .00 20. .46 O

ANISOU 2989 O THR B 200 1848 3987 1937 -329 -328 - 1187 O

ATOM 2990 CB THR B 200 7.778 27. .846 18. .627 1. .00 19. .27 C

ANISOU 2990 CB THR B 200 1821 2554 2945 -381 295 -936 C

ATOM 2991 OG1 THR B 200 8.492 27. .782 17. .376 1. .00 21. .94 O

ANISOU 2991 OG1 THR B 200 1320 4191 2823 342 11 -608 O

ATOM 2992 CG2 THR B 200 7.684 26. .478 19. .290 1. .00 20. .34 C

ANISOU 2992 CG2 THR B 200 1755 2694 3279 -992 66 -745 C

ATOM 2993 N GLY B 201 6.097 30. .042 16. .563 1. .00 22. .54 N

ANISOU 2993 N GLY B 201 2744 3009 2810 -434 -201 -605 N

ATOM 2994 CA GLY B 201 6.405 31. .272 15. .836 1. .00 19. .87 C

ANISOU 2994 CA GLY B 201 2229 2914 2406 -70 -148 -714 C

ATOM 2995 C GLY B 201 7.771 31. .245 15. .165 1. .00 22. .04 C

ANISOU 2995 C GLY B 201 2309 2960 3103 -268 73 -826 C

ATOM 2996 O GLY B 201 8.156 32. .218 14. .518 1. .00 24. .29 O

ANISOU 2996 O GLY B 201 2644 3114 3469 -84 214 -660 O

ATOM 2997 N GLU B 202 8.512 30. .140 15. .310 1. .00 19. .18 N

ANISOU 2997 N GLU B 202 1325 3395 2566 -368 -454 -769 N

ATOM 2998 CA GLU B 202 9.848 30. .031 14. .692 1. .00 19. .53 C

ANISOU 2998 CA GLU B 202 1986 3334 2100 -334 1 - 1333 C

ATOM 2999 C GLU B 202 9.839 28. .989 13. .570 1. .00 18. .29 C

ANISOU 2999 C GLU B 202 1837 2864 2245 -232 197 - 1200 C

ATOM 3000 O GLU B 202 8.983 28. .092 13. .563 1. .00 21. .31 O

ANISOU 3000 O GLU B 202 1654 3282 3160 -465 447 -993 O

ATOM 3001 CB GLU B 202 10.923 29. ,714 15. , 752 1. ,00 23. , 23 C

ANISOU 3001 CB GLU B 202 2370 3559 2896 521 -257 -894 C

ATOM 3002 CG GLU B 202 11.051 30. .805 16. .830 1. .00 26. .87 c

ANISOU 3002 CG GLU B 202 3891 4109 2209 280 -563 -838 c

ATOM 3003 CD GLU B 202 12.083 30. .532 17. .932 1. .00 28. .50 c

ANISOU 3003 CD GLU B 202 3144 3607 4075 1211 -776 -491 c

ATOM 3004 OE1 GLU B 202 12.459 29. .364 18. .168 1. .00 29. .16 0

ANISOU 3004 OE1 GLU B 202 4251 3038 3790 929 57 -471 0

ATOM 3005 OE2 GLU B 202 12.505 31. .506 18. .601 1. .00 31. .72 0

ANISOU 3005 OE2 GLU B 202 2048 7302 2698 -423 -572 - 1508 0

ATOM 3006 N TRP B 203 10.770 29. .126 12. .622 1. .00 19. .41 N

ANISOU 3006 N TRP B 203 1835 3176 2360 14 199 -887 N

ATOM 3007 CA TRP B 203 10.951 28. .137 11. .553 1. .00 19. .48 C

ANISOU 3007 CA TRP B 203 2139 2971 2292 -404 -194 -882 C ATOM 3008 C TRP B 203 11.683 26..915 12..004 1..00 20..10 C

ANISOU 3008 C TRP B 203 2014 3121 2501 -150 -760 - 1306 C

ATOM 3009 O TRP B 203 12.722 27. .000 12. .686 1. .00 21. .56 O

ANISOU 3009 O TRP B 203 2287 3297 2607 -182 -1013 - 1302 O

ATOM 3010 CB TRP B 203 11.687 28. .749 10. .360 1. .00 22. .17 C

ANISOU 3010 CB TRP B 203 1978 3618 2826 -649 -125 -577 C

ATOM 3011 CG TRP B 203 10.785 29. .612 9. .540 1. .00 22. .19 C

ANISOU 3011 CG TRP B 203 2896 3040 2492 -836 53 -310 C

ATOM 3012 CD1 TRP B 203 10.654 30. ₉₉₉ 9. , 581 1. ,00 20. , 37 C

ANISOU 3012 CD1 TRP B 203 2122 2992 2622 -415 228 -481 C

ATOM 3013 CD2 TRP B 203 9.823 29. .156 8. .539 1. .00 21. .11 C

ANISOU 3013 CD2 TRP B 203 2480 3070 2470 -426 58 -371 C

ATOM 3014 NE1 TRP B 203 9.702 31. .420 8. .681 1. .00 21. .61 N

ANISOU 3014 NE1 TRP B 203 2750 3152 2309 -634 -68 -413 N

ATOM 3015 CE2 TRP B 203 9.171 30. .356 8. .019 1. .00 22. .06 C

ANISOU 3015 CE2 TRP B 203 2888 3004 2490 -266 89 -737 C

ATOM 3016 CE3 TRP B 203 9.467 27. .910 8. .024 1. .00 20. .81 C

ANISOU 3016 CE3 TRP B 203 2308 2947 2650 -164 -335 -449 C

ATOM 3017 CZ2 TRP B 203 8.193 30. .286 7. .033 1. .00 21. .29 C

ANISOU 3017 CZ2 TRP B 203 2072 3013 3004 -267 237 - 1122 C

ATOM 3018 CZ3 TRP B 203 8.474 27. ,849 7. , 047 1. ,00 19. , 38 C

ANISOU 3018 CZ3 TRP B 203 2224 3137 2003 -36 4 -339 C

ATOM 3019 CH2 TRP B 203 7.861 29. .010 6. .559 1. .00 18. .32 C

ANISOU 3019 CH2 TRP B 203 1478 2678 2805 -205 329 -665 c

ATOM 3020 N SER B 204 11.145 25. .761 11. .625 1. .00 19. .79 N

ANISOU 3020 N SER B 204 2289 2852 2376 -328 218 - 1044 N

ATOM 3021 CA SER B 204 11.846 24. .502 11. .793 1. .00 20. .98 C

ANISOU 3021 CA SER B 204 2492 3087 2392 -302 -454 -515 C

ATOM 3022 C SER B 204 11.614 23. .608 10. .581 1. .00 19. .18 C

ANISOU 3022 C SER B 204 2216 3013 2058 -42 -248 -402 C

ATOM 3023 O SER B 204 11.191 24. .085 9. .511 1. .00 17. .51 O

ANISOU 3023 O SER B 204 1892 2582 2180 -173 -213 -318 O

ATOM 3024 CB SER B 204 11.421 23. ,807 13. , 084 1. ,00 21. , 47 C

ANISOU 3024 CB SER B 204 2106 3762 2287 -301 -400 -522 c

ATOM 3025 OG SER B 204 12.377 22. .819 13. .420 1. .00 23. .87 0

ANISOU 3025 OG SER B 204 3818 3267 1982 84 -1151 -882 0

ATOM 3026 N LYS B 205 11.879 22. .315 10. .726 1. .00 16. .61 N

ANISOU 3026 N LYS B 205 1494 3014 1802 -153 -205 -580 N

ATOM 3027 CA LYS B 205 11.659 21. .387 9. .607 1. .00 15. .94 C

ANISOU 3027 CA LYS B 205 1683 2725 1648 -255 -214 -420 C

ATOM 3028 C LYS B 205 11.502 19. .944 10. .057 1. .00 17. .28 C

ANISOU 3028 C LYS B 205 1780 2677 2107 -71 -253 -507 C

ATOM 3029 O LYS B 205 11.977 19. .547 11. .151 1. .00 18. .57 O

ANISOU 3029 O LYS B 205 1452 3396 2208 91 -318 -633 O

ATOM 3030 CB LYS B 205 12.773 21. .511 8. .542 1. .00 16. .28 c

ANISOU 3030 CB LYS B 205 1521 3037 1627 -8 -342 -234 c

ATOM 3031 CG LYS B 205 14.149 21. .037 8. .989 1. .00 21. .56 c

ANISOU 3031 CG LYS B 205 1368 3683 3141 125 -364 -570 c

ATOM 3032 CD LYS B 205 15.228 21. .449 7. .988 1. .00 25. .91 c

ANISOU 3032 CD LYS B 205 1699 4417 3728 56 49 -486 c

ATOM 3033 CE LYS B 205 16.628 21. .192 8. .523 1. .00 32. .46 c

ANISOU 3033 CE LYS B 205 2703 4960 4670 1543 -691 -453 c

ATOM 3034 NZ LYS B 205 16.951 19. .740 8. .518 1. .00 36. .76 N

ANISOU 3034 NZ LYS B 205 3115 5259 5590 1873 -1141 - 1046 N

ATOM 3035 N THR B 206 10.848 19. .171 9. .193 1. .00 15. .31 N

ANISOU 3035 N THR B 206 1247 2254 2314 227 -478 -375 N

ATOM 3036 CA THR B 206 10.663 17. .726 9. .362 1. .00 15. .98 C

ANISOU 3036 CA THR B 206 1565 2412 2093 96 -215 -413 C

ATOM 3037 C THR B 206 11.064 17. .059 8. .058 1. .00 17. .44 C

ANISOU 3037 C THR B 206 1762 2548 2314 517 -189 -515 C

ATOM 3038 O THR B 206 10.663 17. ,522 6. , 975 1. ,00 18. ,01 O ANISOU 3038 O THR B 206 2066 2625 2150 416 -170 ^■465 O

ATOM 3039 CB THR B 206 9.182 17. .419 9. .672 1. .00 15. .47 C

ANISOU 3039 CB THR B 206 1336 2434 2105 476 -259 ^■180 C

ATOM 3040 OG1 THR B 206 8.856 17. .988 10. .945 1. .00 18. .73 O

ANISOU 3040 OG1 THR B 206 1671 2980 2464 376 -375 ^■743 O

ATOM 3041 CG2 THR B 206 8.898 15. .929 9. .707 1. .00 15. .18 C

ANISOU 3041 CG2 THR B 206 1353 2465 1946 470 -637 ^■279 C

ATOM 3042 N VAL B 207 11.841 15. .984 8. .156 1. .00 16. .32 N

ANISOU 3042 N VAL B 207 1980 2634 1585 662 -240 ^■523 N

ATOM 3043 CA VAL B 207 12.364 15. .297 6. .979 1. .00 16. .77 C

ANISOU 3043 CA VAL B 207 1614 2782 1975 460 19 ^■731 C

ATOM 3044 C VAL B 207 11.726 13. .921 6. .894 1. .00 16. .08 C

ANISOU 3044 C VAL B 207 1768 2465 1877 657 94 ^■395 C

ATOM 3045 O VAL B 207 11.717 13. .172 7. .871 1. .00 18. .94 O

ANISOU 3045 O VAL B 207 2600 2435 2158 576 -458 ^■288 O

ATOM 3046 CB VAL B 207 13.914 15. .183 7. .028 1. .00 17. .14 C

ANISOU 3046 CB VAL B 207 1547 3119 1845 200 9 ^■460 C

ATOM 3047 CGI VAL B 207 14.459 14. .399 5. .833 1. .00 17. .56 c

ANISOU 3047 CGI VAL B 207 1929 3045 1696 470 -306 ^■404 c

ATOM 3048 CG2 VAL B 207 14.550 16. .576 7. .134 1. .00 21. .13 c

ANISOU 3048 CG2 VAL B 207 1915 3430 2683 -13 267 ^■486 c

ATOM 3049 N PHE B 208 11.160 13. .630 5. .725 1. .00 16. .16 N

ANISOU 3049 N PHE B 208 1601 2326 2212 483 -63 ^■498 N

ATOM 3050 CA PHE B 208 10.441 12. .396 5. .454 1. .00 15. .75 C

ANISOU 3050 CA PHE B 208 1624 2210 2150 594 -132 ^■576 C

ATOM 3051 C PHE B 208 11.243 11. .581 4. .463 1. .00 15. .76 C

ANISOU 3051 C PHE B 208 1356 2353 2278 447 172 ^■402 C

ATOM 3052 O PHE B 208 12.010 12. ,140 3. ,680 1. ,00 16. ,09 O

ANISOU 3052 O PHE B 208 2022 2644 1445 834 487 ^■391 O

ATOM 3053 CB PHE B 208 9.077 12. .711 4. .821 1. .00 16. .26 c

ANISOU 3053 CB PHE B 208 1353 2660 2162 138 -115 ^■549 c

ATOM 3054 CG PHE B 208 8.156 13. .497 5. .708 1. .00 15. .90 c

ANISOU 3054 CG PHE B 208 1838 2377 1823 168 -73 ^■390 c

ATOM 3055 CD1 PHE B 208 8.264 14. .887 5. .797 1. ,00 15. ,11 c

ANISOU 3055 CD1 PHE B 208 1311 2534 1894 10 -450 ^■782 c

ATOM 3056 CD2 PHE B 208 7.148 12. .850 6. .427 1. .00 14. .91 c

ANISOU 3056 CD2 PHE B 208 1747 2419 1496 228 -83 ^■310 c

ATOM 3057 CE1 PHE B 208 7.417 15. .615 6. .613 1. .00 14. .84 c

ANISOU 3057 CE1 PHE B 208 1326 2685 1628 261 -327 ^■321 c

ATOM 3058 CE2 PHE B 208 6.301 13. .573 7. .251 1. .00 15. .16 c

ANISOU 3058 CE2 PHE B 208 1709 2163 1886 314 -53 ^■242 c

ATOM 3059 CZ PHE B 208 6.421 14. .961 7. .329 1. .00 15. .08 c

ANISOU 3059 CZ PHE B 208 1849 2206 1673 110 -218 ^■203 c

ATOM 3060 N GLU B 209 11.062 10. .266 4. .497 1. .00 16. .14 N

ANISOU 3060 N GLU B 209 1731 2328 2072 534 -134 ^■557 N

ATOM 3061 CA GLU B 209 11.719 9. .378 3. .551 1. .00 15. .57 C

ANISOU 3061 CA GLU B 209 1647 2122 2145 572 20 ^■358 c

ATOM 3062 C GLU B 209 10.760 8. .268 3. .168 1. .00 16. .92 c

ANISOU 3062 C GLU B 209 2219 2294 1913 381 137 ^■357 c

ATOM 3063 O GLU B 209 10.003 7. ,762 4. ,003 1. ,00 19. , 58 0

ANISOU 3063 O GLU B 209 2448 2626 2362 -173 7 -6 0

ATOM 3064 CB GLU B 209 13.008 8. .814 4. .173 1. .00 18. .63 c

ANISOU 3064 CB GLU B 209 1886 2142 3050 476 -262 102 c

ATOM 3065 CG GLU B 209 13.708 7. .722 3. .390 1. .00 22. .56 c

ANISOU 3065 CG GLU B 209 1727 2817 4027 611 -401 ^■521 c

ATOM 3066 CD GLU B 209 14.878 7. .140 4. .177 1. .00 29. .73 c

ANISOU 3066 CD GLU B 209 2168 3677 5451 1492 -346 69 c

ATOM 3067 OE1 GLU B 209 15.951 7. .755 4. .172 1. .00 41. .31 0

ANISOU 3067 OE1 GLU B 209 2216 6120 7358 808 -798 63 0

ATOM 3068 OE2 GLU B 209 14.714 6. .087 4. .831 1. .00 44. .58 0

ANISOU 3068 OE2 GLU B 209 5191 4597 7150 1137 -232 886 0 ATOM 3069 N TYR B 210 10.774 7.,904 1.,894 1..00 16.,86 N

ANISOU 3069 N TYR B 210 1950 2489 1964 187 -133 -504 N

ATOM 3070 CA TYR B 210 10.073 6. .729 1. .468 1, .00 16. .96 C

ANISOU 3070 CA TYR B 210 2097 2455 1889 255 -173 -598 C

ATOM 3071 C TYR B 210 11.042 5. .838 0. .718 1, .00 16. .91 C

ANISOU 3071 C TYR B 210 1928 2348 2148 225 -53 -442 C

ATOM 3072 O TYR B 210 11.712 6. .287 -0. ,223 1. .00 17. , 66 O

ANISOU 3072 O TYR B 210 1585 2660 2462 33 -113 -416 O

ATOM 3073 CB TYR B 210 8.868 7. .086 0. .591 1, .00 16. .71 C

ANISOU 3073 CB TYR B 210 1711 2364 2272 40 -3 -234 C

ATOM 3074 CG TYR B 210 8.031 5. .865 0. .273 1, .00 17. .68 C

ANISOU 3074 CG TYR B 210 1610 2704 2401 -142 275 -650 C

ATOM 3075 CD1 TYR B 210 7.340 5. .175 1. .280 1, .00 19. .47 C

ANISOU 3075 CD1 TYR B 210 2492 1993 2910 -381 170 -243 C

ATOM 3076 CD2 TYR B 210 7.966 5. .372 -1. ,017 1. .00 18. , 80 C

ANISOU 3076 CD2 TYR B 210 2255 2741 2144 -267 43 -350 C

ATOM 3077 CE1 TYR B 210 6.584 4. .042 0. .986 1, .00 18. .23 C

ANISOU 3077 CE1 TYR B 210 1966 2315 2644 -370 16 -458 C

ATOM 3078 CE2 TYR B 210 7.215 4. ,252 -1. ,320 1. .00 19. ,71 C

ANISOU 3078 CE2 TYR B 210 2084 2678 2727 -294 236 -169 C

ATOM 3079 CZ TYR B 210 6.527 3. .584 -0. ,326 1. .00 19. , 51 C

ANISOU 3079 CZ TYR B 210 2151 2698 2561 -454 181 -301 C

ATOM 3080 OH TYR B 210 5.780 2. .466 -0. ,664 1. .00 21. , 36 O

ANISOU 3080 OH TYR B 210 2313 3068 2732 -649 179 -709 0

ATOM 3081 N ARG B 211 11.127 4. .586 1. .157 1, .00 15. .91 N

ANISOU 3081 N ARG B 211 1971 2309 1762 22 306 -321 N

ATOM 3082 CA ARG B 211 11.959 3. .579 0. .496 1, .00 18. .54 C

ANISOU 3082 CA ARG B 211 2361 2360 2322 174 42 -688 C

ATOM 3083 C ARG B 211 11.087 2. .395 0. .105 1, .00 21. .33 C

ANISOU 3083 C ARG B 211 3086 2631 2387 -490 350 -402 C

ATOM 3084 O ARG B 211 10.212 1. .975 0. .884 1, .00 20. .79 O

ANISOU 3084 O ARG B 211 2528 2505 2866 -1033 158 -485 O

ATOM 3085 CB ARG B 211 13.086 3. .110 1. .420 1, .00 23. .08 c

ANISOU 3085 CB ARG B 211 3068 3076 2626 -280 -564 -47 c

ATOM 3086 CG ARG B 211 13.989 4. .232 1. .924 1, .00 25. .90 c

ANISOU 3086 CG ARG B 211 3050 3042 3749 66 -876 -282 c

ATOM 3087 CD ARG B 211 14.870 3. .777 3. .078 1, .00 30. .65 c

ANISOU 3087 CD ARG B 211 4241 3685 3720 81 -1472 -623 c

ATOM 3088 NE ARG B 211 15.736 2. .658 2. .732 1, .00 38. .15 N

ANISOU 3088 NE ARG B 211 4005 6411 4077 888 -820 - 1985 N

ATOM 3089 CZ ARG B 211 16.817 2. .755 1. .966 1, .00 42. .46 C

ANISOU 3089 CZ ARG B 211 4821 6094 5218 1057 -342 - 1436 C

ATOM 3090 NH1 ARG B 211 17.177 3. .928 1. .453 1, .00 50. .00 N

ANISOU 3090 NH1 ARG B 211 5864 6833 6299 1091 -1238 130 N

ATOM 3091 NH2 ARG B 211 17.542 1. .673 1. .711 1, .00 49. .70 N

ANISOU 3091 NH2 ARG B 211 7118 6531 5232 1953 -874 - 2901 N

ATOM 3092 N THR B 212 11.315 1. ,858 -1. ,095 1. .00 18. ,89 N

ANISOU 3092 N THR B 212 2741 2006 2430 -212 -100 -434 N

ATOM 3093 CA THR B 212 10.460 0. .784 -1. ,609 1. .00 18. , 60 C

ANISOU 3093 CA THR B 212 2623 2058 2384 -259 120 -463 C

ATOM 3094 C THR B 212 11.178 -0. ,130 -2. ,603 1. .00 18. , 07 C

ANISOU 3094 C THR B 212 2457 1805 2601 -505 97 -664 C

ATOM 3095 O THR B 212 12.114 0. .296 -3. ,300 1. .00 19. , 98 O

ANISOU 3095 O THR B 212 2563 2370 2656 -92 578 -473 O

ATOM 3096 CB THR B 212 9.163 1. .351 -2. ,249 1. .00 17. , 70 C

ANISOU 3096 CB THR B 212 2454 2017 2254 -311 201 -436 C

ATOM 3097 OG1 THR B 212 8.346 0. .275 -2. ,703 1. .00 18. , 04 O

ANISOU 3097 OG1 THR B 212 2136 2134 2584 -190 405 -704 O

ATOM 3098 CG2 THR B 212 9.488 2. .286 -3. ,431 1. .00 19. , 24 C

ANISOU 3098 CG2 THR B 212 2908 2163 2238 -235 -88 -287 C

ATOM 3099 N ARG B 213 10.732 -1. ,383 -2. ,655 1. .00 17. , 87 N ANISOU 3099 N ARG B 213 2534 1685 2571 -421 415 -374 N

ATOM 3100 CA ARG B 213 11.178 -2. ,340 -3. .666 1. .00 18. .40 C

ANISOU 3100 CA ARG B 213 2513 2178 2301 -135 -28 -548 C

ATOM 3101 C ARG B 213 10.277 -2. ,290 -4. .904 1. .00 17. .66 C

ANISOU 3101 C ARG B 213 2651 2073 1985 -144 83 -387 C

ATOM 3102 O ARG B 213 10.498 -3. ,015 -5. .871 1. .00 20. .34 0

ANISOU 3102 O ARG B 213 2882 2413 2433 -9 141 -760 0

ATOM 3103 CB ARG B 213 11.178 -3. ,755 -3. .086 1. .00 21. .88 c

ANISOU 3103 CB ARG B 213 3503 2080 2729 44 381 -589 c

ATOM 3104 CG ARG B 213 12.400 -4. ,063 -2. .239 1. .00 31. .60 c

ANISOU 3104 CG ARG B 213 4893 3479 3634 171 - 904 -831 c

ATOM 3105 CD ARG B 213 12.161 -5. ,303 -1. .395 1. .00 39. .56 c

ANISOU 3105 CD ARG B 213 6478 3170 5383 -175 - 175 - 1024 c

ATOM 3106 NE ARG B 213 13.226 -6. ,301 -1. .534 1. .00 50. .21 N

ANISOU 3106 NE ARG B 213 7186 4661 7227 972 - 582 -919 N

ATOM 3107 CZ ARG B 213 13.241 -7. ,285 -2. .437 1. .00 53. .06 C

ANISOU 3107 CZ ARG B 213 8144 5735 6279 1335 -77 - 1058 C

ATOM 3108 NH1 ARG B 213 12.257 -7. ,420 -3. .324 1. .00 59. .13 N

ANISOU 3108 NH1 ARG B 213 8999 7331 6134 2125 - 847 -292 N

ATOM 3109 NH2 ARG B 213 14.256 -8. ,141 -2. .461 1. .00 63. .30 N

ANISOU 3109 NH2 ARG B 213 9121 5536 9392 1985 - 775 -199 N

ATOM 3110 N LYS B 214 9.248 -1. ,450 -4. .856 1. .00 17. .60 N

ANISOU 3110 N LYS B 214 2237 2125 2325 -435 9 -487 N

ATOM 3111 CA LYS B 214 8.374 -1. ,229 -6. .003 1. .00 15. .64 C

ANISOU 3111 CA LYS B 214 1684 2268 1990 -6 413 -139 C

ATOM 3112 C LYS B 214 8.638 0. .204 -6. .488 1. .00 16. .22 C

ANISOU 3112 C LYS B 214 1640 2444 2078 -309 411 -213 C

ATOM 3113 O LYS B 214 7.898 1. .152 -6. .145 1. .00 17. .47 O

ANISOU 3113 O LYS B 214 1688 2832 2116 91 56 -11 O

ATOM 3114 CB LYS B 214 6.900 -1. ,448 -5. .608 1. .00 19. .22 C

ANISOU 3114 CB LYS B 214 1519 3575 2208 -274 69 -851 C

ATOM 3115 CG LYS B 214 5.947 -1. ,624 -6. .783 1. .00 26. .69 C

ANISOU 3115 CG LYS B 214 2769 4788 2581 -118 - 783 -123 C

ATOM 3116 N ALA B 215 9.703 0. .365 -7. .281 1. .00 13. .49 N

ANISOU 3116 N ALA B 215 1128 2285 1712 -309 -89 32 N

ATOM 3117 CA ALA B 215 10.183 1. ,700 -7. .648 1. .00 12. .66 C

ANISOU 3117 CA ALA B 215 1049 2200 1558 -135 420 -64 C

ATOM 3118 C ALA B 215 9.204 2. .548 -8. .478 1. .00 14. .16 C

ANISOU 3118 C ALA B 215 1063 2129 2186 -69 47 -284 C

ATOM 3119 O ALA B 215 9.375 3. .764 -8. .565 1. .00 15. .56 O

ANISOU 3119 O ALA B 215 1070 2159 2681 -71 173 -570 O

ATOM 3120 CB ALA B 215 11.551 1. .616 -8. .344 1. .00 12. .49 C

ANISOU 3120 CB ALA B 215 687 2237 1822 278 78 -274 C

ATOM 3121 N VAL B 216 8.180 1. .946 -9. .089 1. .00 15. .31 N

ANISOU 3121 N VAL B 216 1149 2604 2061 -60 43 -437 N

ATOM 3122 CA VAL B 216 7.191 2. .772 -9. .813 1. .00 12. .99 C

ANISOU 3122 CA VAL B 216 1595 1636 1703 -7 18 -690 C

ATOM 3123 C VAL B 216 6.424 3. ,741 -8. .893 1. .00 14. .11 C

ANISOU 3123 C VAL B 216 1489 1994 1876 36 264 -647 C

ATOM 3124 O VAL B 216 5.850 4. .705 -9. .371 1. .00 15. .06 O

ANISOU 3124 O VAL B 216 1520 2111 2091 185 134 -599 O

ATOM 3125 CB VAL B 216 6.173 1. .947 -10. .635 1. .00 14. .76 C

ANISOU 3125 CB VAL B 216 1531 2137 1939 -329 219 -841 C

ATOM 3126 CGI VAL B 216 6.826 1. .356 -11. .883 1. .00 15. .31 c

ANISOU 3126 CGI VAL B 216 1622 2569 1625 152 - 365 - 1024 c

ATOM 3127 CG2 VAL B 216 5.487 0. .894 -9. .764 1. .00 16. .62 c

ANISOU 3127 CG2 VAL B 216 1904 2327 2081 -420 161 -515 c

ATOM 3128 N ARG B 217 6.446 3. .491 -7. .585 1. .00 14. .52 N

ANISOU 3128 N ARG B 217 1266 2302 1946 46 3 -434 N

ATOM 3129 CA ARG B 217 5.826 4. .383 -6. .596 1. .00 15. .77 C

ANISOU 3129 CA ARG B 217 1999 2109 1883 -133 397 -300 C ATOM 3130 C ARG B 217 6.516 5..744 -6..467 1..00 14..00 C

ANISOU 3130 C ARG B 217 1258 2049 2009 204 321 -739 C

ATOM 3131 O ARG B 217 5.917 6. .717 -6. .002 1. .00 15. .90 O

ANISOU 3131 O ARG B 217 1687 2119 2234 366 510 -749 O

ATOM 3132 CB ARG B 217 5.771 3. ,691 -5. .231 1. .00 14. .96 C

ANISOU 3132 CB ARG B 217 1698 2276 1707 -303 414 -444 C

ATOM 3133 CG ARG B 217 4.870 2. .471 -5. .238 1. .00 17. .13 C

ANISOU 3133 CG ARG B 217 1709 2627 2172 -595 352 -496 C

ATOM 3134 CD ARG B 217 4.927 1. .750 -3. .909 1. .00 18. .88 C

ANISOU 3134 CD ARG B 217 2231 2311 2628 -715 982 -234 C

ATOM 3135 NE ARG B 217 4.168 0. .512 -3. .966 1. .00 23. .11 N

ANISOU 3135 NE ARG B 217 3146 2432 3203 -1081 687 -99 N

ATOM 3136 CZ ARG B 217 4.294 -0. ,479 -3. .090 1. .00 23. .20 C

ANISOU 3136 CZ ARG B 217 2859 2602 3353 -853 763 27 C

ATOM 3137 NH1 ARG B 217 5.161 -0. ,377 -2. .088 1. .00 24. .99 N

ANISOU 3137 NH1 ARG B 217 3147 3549 2795 -55 1111 -703 N

ATOM 3138 NH2 ARG B 217 3.565 -1. ,577 -3. .225 1. .00 25. .83 N

ANISOU 3138 NH2 ARG B 217 3296 2827 3688 -1127 1495 -945 N

ATOM 3139 N LEU B 218 7.778 5. .806 -6. .881 1. .00 13. .88 N

ANISOU 3139 N LEU B 218 1106 1972 2194 29 141 -477 N

ATOM 3140 CA LEU B 218 8.548 7. .040 -6. .771 1. .00 13. .68 C

ANISOU 3140 CA LEU B 218 1331 1927 1940 44 -112 -413 C

ATOM 3141 C LEU B 218 8.794 7. .572 -8. .174 1. .00 13. .22 C

ANISOU 3141 C LEU B 218 1273 1757 1994 249 -161 -302 C

ATOM 3142 O LEU B 218 8.637 6. .833 -9. .142 1. .00 15. .06 O

ANISOU 3142 O LEU B 218 1375 2009 2335 4 -66 -563 O

ATOM 3143 CB LEU B 218 9.870 6. .790 -6. .011 1. .00 13. .81 C

ANISOU 3143 CB LEU B 218 1163 2135 1948 246 64 -253 C

ATOM 3144 CG LEU B 218 9.699 6. ,625 -4. .486 1. .00 12. .66 C

ANISOU 3144 CG LEU B 218 1369 1621 1817 510 -384 -327 C

ATOM 3145 CD1 LEU B 218 10.965 6. .150 -3. .779 1. .00 13. .53 C

ANISOU 3145 CD1 LEU B 218 1247 1941 1950 300 -292 157 C

ATOM 3146 CD2 LEU B 218 9.223 7. .925 -3. .867 1. .00 12. .46 C

ANISOU 3146 CD2 LEU B 218 1291 1574 1868 217 -279 -512 C

ATOM 3147 N PRO B 219 9.160 8. .856 -8. .303 1. .00 12. .76 N

ANISOU 3147 N PRO B 219 1352 1834 1662 72 -59 -385 N

ATOM 3148 CA PRO B 219 9.375 9. .839 -7. .242 1. .00 13. .11 C

ANISOU 3148 CA PRO B 219 1358 1602 2020 -92 277 -519 C

ATOM 3149 C PRO B 219 8.076 10. .426 -6. .647 1. .00 13. .53 C

ANISOU 3149 C PRO B 219 1480 1928 1732 161 74 -668 C

ATOM 3150 O PRO B 219 6.950 10. .164 -7. .131 1. .00 14. .14 O

ANISOU 3150 O PRO B 219 1564 1893 1914 261 -235 -343 O

ATOM 3151 CB PRO B 219 10.152 10. .949 -7. .964 1. .00 14. .34 C

ANISOU 3151 CB PRO B 219 1697 2090 1661 71 370 -113 C

ATOM 3152 CG PRO B 219 9.619 10. .890 -9. .359 1. .00 13. .75 C

ANISOU 3152 CG PRO B 219 1873 1585 1767 383 124 -205 c

ATOM 3153 CD PRO B 219 9.359 9. .437 -9. .645 1. .00 13. .76 c

ANISOU 3153 CD PRO B 219 1568 1719 1941 101 325 -271 c

ATOM 3154 N ILE B 220 8.256 11. .210 -5. .595 1. .00 12. .74 N

ANISOU 3154 N ILE B 220 1557 1809 1473 215 201 -498 N

ATOM 3155 CA ILE B 220 7.183 12. .019 -5. .015 1. .00 12. .86 C

ANISOU 3155 CA ILE B 220 1308 1808 1768 343 23 -404 C

ATOM 3156 C ILE B 220 6.809 13. .139 -5. .991 1. .00 14. .54 C

ANISOU 3156 C ILE B 220 1607 1833 2084 80 45 -233 C

ATOM 3157 O ILE B 220 7.686 13. .853 -6. .507 1. .00 15. .94 O

ANISOU 3157 O ILE B 220 1260 2351 2445 202 171 42 O

ATOM 3158 CB ILE B 220 7.650 12. ,611 -3. .670 1. .00 12. .99 c

ANISOU 3158 CB ILE B 220 1549 1731 1655 341 272 -381 c

ATOM 3159 CGI ILE B 220 7.899 11. .485 -2. .652 1. .00 14. .93 c

ANISOU 3159 CGI ILE B 220 2311 1999 1361 357 -59 -473 c

ATOM 3160 CG2 ILE B 220 6.644 13. .632 -3. .144 1. .00 13. .29 c ANISOU 3160 CG2 ILE B 220 1621 1867 1558 288 431 -563 C

ATOM 3161 CD1 ILE B 220 8.905 11. .828 -1. .567 1. .00 15. .02 C

ANISOU 3161 CD1 ILE B 220 1945 2345 1414 745 -119 -336 C

ATOM 3162 N VAL B 221 5.515 13. .289 -6. .275 1. .00 15. .43 N

ANISOU 3162 N VAL B 221 1624 2148 2088 307 115 -118 N

ATOM 3163 CA VAL B 221 5.070 14. .348 -7. .207 1. .00 16. .87 C

ANISOU 3163 CA VAL B 221 2368 1914 2126 534 -238 -439 C

ATOM 3164 C VAL B 221 4.290 15. .497 -6. .569 1. .00 14. .45 C

ANISOU 3164 C VAL B 221 1474 1806 2209 279 -343 -341 C

ATOM 3165 O VAL B 221 4.104 16. .539 -7. .195 1. .00 16. .75 O

ANISOU 3165 O VAL B 221 2111 1931 2320 235 -373 -172 O

ATOM 3166 CB VAL B 221 4.303 13. .779 -8. .421 1. .00 17. .89 C

ANISOU 3166 CB VAL B 221 1933 2618 2245 351 -140 -459 C

ATOM 3167 CGI VAL B 221 5.209 12. .813 -9. .189 1. .00 19. .03 C

ANISOU 3167 CGI VAL B 221 2344 2707 2178 685 -412 -634 C

ATOM 3168 CG2 VAL B 221 3.007 13. .102 -7. .978 1. .00 17. .42 c

ANISOU 3168 CG2 VAL B 221 1801 2715 2100 93 -371 -849 c

ATOM 3169 N ASP B 222 3.841 15. .306 -5. .329 1. .00 14. .13 N

ANISOU 3169 N ASP B 222 1313 1985 2069 270 -387 -567 N

ATOM 3170 CA ASP B 222 3.055 16. .328 -4. .637 1. .00 15. .84 C

ANISOU 3170 CA ASP B 222 1641 2360 2016 503 -416 -676 C

ATOM 3171 C ASP B 222 3.101 16. .098 -3. .139 1. .00 16. .45 C

ANISOU 3171 C ASP B 222 1594 2465 2188 401 -155 -412 C

ATOM 3172 O ASP B 222 3.503 15. ,018 -2. .684 1. .00 14. .65 O

ANISOU 3172 O ASP B 222 1010 2423 2131 305 -257 -570 O

ATOM 3173 CB ASP B 222 1.600 16. .338 -5. .141 1. .00 18. .26 c

ANISOU 3173 CB ASP B 222 1584 2692 2660 570 -412 -400 c

ATOM 3174 CG ASP B 222 0.958 17. .717 -5. .066 1. .00 18. .73 c

ANISOU 3174 CG ASP B 222 1816 2799 2501 705 -1074 -472 c

ATOM 3175 OD1 ASP B 222 1.478 18. .588 -4. .321 1. .00 17. .95 0

ANISOU 3175 OD1 ASP B 222 1633 2741 2444 505 -517 -534 0

ATOM 3176 OD2 ASP B 222 -0.094 17. ,925 -5. .743 1. .00 18. .82 0

ANISOU 3176 OD2 ASP B 222 1484 3277 2388 1246 -650 -475 0

ATOM 3177 N ILE B 223 2.666 17. .114 -2. .386 1. .00 16. .75 N

ANISOU 3177 N ILE B 223 1545 2589 2227 61 -396 -826 N

ATOM 3178 CA ILE B 223 2.660 17. ,084 -0. .932 1. .00 15. .41 C

ANISOU 3178 CA ILE B 223 1063 2610 2179 181 -167 -670 C

ATOM 3179 C ILE B 223 1.367 17. .721 -0. .398 1. .00 15. .50 C

ANISOU 3179 C ILE B 223 1514 2009 2364 393 20 -586 C

ATOM 3180 O ILE B 223 0.895 18. .734 -0. .933 1. .00 16. .53 0

ANISOU 3180 O ILE B 223 1619 2466 2194 593 -446 -593 0

ATOM 3181 CB ILE B 223 3.916 17. .788 -0. .350 1. .00 15. .99 c

ANISOU 3181 CB ILE B 223 1472 2361 2241 -155 -460 -115 c

ATOM 3182 CGI ILE B 223 3.930 17. .717 1, .179 1, .00 16, .54 c

ANISOU 3182 CGI ILE B 223 1853 2206 2223 -165 -500 -494 c

ATOM 3183 CG2 ILE B 223 4.012 19. .240 -0. .825 1. .00 14. .62 c

ANISOU 3183 CG2 ILE B 223 1611 2103 1840 -188 -524 -463 c

ATOM 3184 CD1 ILE B 223 5.289 18. .004 1, .782 1, .00 18, .83 c

ANISOU 3184 CD1 ILE B 223 1933 2726 2493 -258 -734 66 c

ATOM 3185 N ALA B 224 0.786 17. .114 0, .629 1, .00 14, .82 N

ANISOU 3185 N ALA B 224 1406 2099 2123 234 132 -941 N

ATOM 3186 CA ALA B 224 -0.482 17. ,615 1. .175 1. .00 15. .15 C

ANISOU 3186 CA ALA B 224 1171 2183 2403 197 32 -955 C

ATOM 3187 C ALA B 224 -0.365 17. ,842 2. .662 1. .00 15. .21 C

ANISOU 3187 C ALA B 224 1236 2237 2305 174 -106 -474 c

ATOM 3188 O ALA B 224 -0.519 16. ,899 3. .440 1. .00 16. .85 0

ANISOU 3188 O ALA B 224 1398 2395 2607 22 121 -325 0

ATOM 3189 CB ALA B 224 -1.628 16. ,653 0. .892 1. .00 16. .81 c

ANISOU 3189 CB ALA B 224 1644 2522 2220 -106 -219 -915 c

ATOM 3190 N PRO B 225 -0.076 19. ,090 3. .080 1. .00 15. .91 N

ANISOU 3190 N PRO B 225 1552 2354 2138 136 218 -618 N ATOM 3191 CA PRO B 225 -0.101 19.,333 4..520 1..00 16..83 C

ANISOU 3191 CA PRO B 225 1342 2962 2090 -16 -244 -692 C

ATOM 3192 C PRO B 225 -1.527 19. ,315 5. .046 1. .00 17. .85 C

ANISOU 3192 C PRO B 225 1720 3014 2047 138 252 -857 C

ATOM 3193 O PRO B 225 -2.491 19. ,439 4. .263 1. .00 20. .98 O

ANISOU 3193 O PRO B 225 1881 3493 2595 417 -38 - 1172 O

ATOM 3194 CB PRO B 225 0.483 20. .744 4, .660 1, .00 16, .13 C

ANISOU 3194 CB PRO B 225 1447 2808 1872 5 191 -521 C

ATOM 3195 CG PRO B 225 1.102 21. .060 3, .334 1, .00 14, .97 C

ANISOU 3195 CG PRO B 225 1609 2539 1538 193 -40 -554 C

ATOM 3196 CD PRO B 225 0.303 20. .296 2, .329 1, .00 17, .08 C

ANISOU 3196 CD PRO B 225 1932 2202 2354 -296 -55 -678 C

ATOM 3197 N TYR B 226 -1.658 19. ,144 6. .353 1. .00 18. .81 N

ANISOU 3197 N TYR B 226 1436 3635 2073 210 239 -691 N

ATOM 3198 CA TYR B 226 -2.965 19. ,197 7. .022 1. .00 18. .90 C

ANISOU 3198 CA TYR B 226 1602 3523 2057 97 357 -854 C

ATOM 3199 C TYR B 226 -3.033 20. ,439 7. .911 1. .00 19. .82 C

ANISOU 3199 C TYR B 226 1838 3214 2475 380 -7 -764 C

ATOM 3200 O TYR B 226 -3.974 21. ,233 7. .827 1. .00 20. .62 O

ANISOU 3200 O TYR B 226 1409 3197 3229 150 -160 -767 O

ATOM 3201 CB TYR B 226 -3.152 17. ,918 7. .836 1. .00 20. .07 C

ANISOU 3201 CB TYR B 226 1880 3299 2444 45 451 -784 C

ATOM 3202 CG TYR B 226 -4.424 17. ,834 8. .614 1. .00 21. .83 c

ANISOU 3202 CG TYR B 226 1695 3852 2745 -328 307 -713 c

ATOM 3203 CD1 TYR B 226 -4.572 18. ,518 9. .813 1. .00 24. .09 c

ANISOU 3203 CD1 TYR B 226 1837 4379 2936 32 621 -911 c

ATOM 3204 CD2 TYR B 226 -5.487 17. ,038 8. .163 1. .00 22. .56 c

ANISOU 3204 CD2 TYR B 226 1024 4334 3212 -449 388 -199 c

ATOM 3205 CE1 TYR B 226 -5.754 18. ,435 10. .537 1. .00 30. .96 c

ANISOU 3205 CE1 TYR B 226 2005 5661 4094 -802 1025 -556 c

ATOM 3206 CE2 TYR B 226 -6.669 16. ,940 8. .888 1. .00 25. .50 c

ANISOU 3206 CE2 TYR B 226 1670 5300 2718 -514 762 -529 c

ATOM 3207 CZ TYR B 226 -6.792 17. ,644 10. .064 1. .00 29. .08 c

ANISOU 3207 CZ TYR B 226 2489 5745 2813 -678 770 -718 c

ATOM 3208 OH TYR B 226 -7.957 17. ,556 10. .776 1. .00 40. .37 0

ANISOU 3208 OH TYR B 226 2966 7793 4578 -2093 1491 -589 0

ATOM 3209 N ASP B 227 -2.030 20. ,609 8. .768 1. .00 16. .76 N

ANISOU 3209 N ASP B 227 1401 2535 2433 -13 318 -855 N

ATOM 3210 CA ASP B 227 -2.036 21. ,726 9. .715 1. .00 17. .54 C

ANISOU 3210 CA ASP B 227 1980 2460 2223 300 37 -714 c

ATOM 3211 C ASP B 227 -1.563 23. ,036 9. .076 1. .00 17. .47 c

ANISOU 3211 C ASP B 227 2167 2232 2237 440 172 -802 c

ATOM 3212 O ASP B 227 -0.485 23. ,558 9. .394 1. .00 20. .96 0

ANISOU 3212 O ASP B 227 2375 2789 2798 406 -158 -925 0

ATOM 3213 CB ASP B 227 -1.217 21. ,370 10. .966 1. .00 18. .03 c

ANISOU 3213 CB ASP B 227 2025 2422 2400 227 -196 -727 c

ATOM 3214 CG ASP B 227 -1.318 22. ,425 12. .054 1. .00 16. .79 c

ANISOU 3214 CG ASP B 227 1905 2189 2284 545 22 -540 c

ATOM 3215 OD1 ASP B 227 -2.392 23. ,079 12. .197 1. .00 18. .49 0

ANISOU 3215 OD1 ASP B 227 1546 2835 2642 252 811 -765 0

ATOM 3216 OD2 ASP B 227 -0.310 22. ,595 12. .771 1. .00 17. .08 0

ANISOU 3216 OD2 ASP B 227 1684 2085 2719 218 78 -650 0

ATOM 3217 N ILE B 228 -2.388 23. ,553 8. .170 1. .00 18. .46 N

ANISOU 3217 N ILE B 228 1702 2714 2598 395 129 -833 N

ATOM 3218 CA ILE B 228 -2.089 24. ,750 7. .376 1. .00 19. .63 C

ANISOU 3218 CA ILE B 228 2454 2274 2728 776 -61 -898 C

ATOM 3219 C ILE B 228 -3.366 25. ,574 7. .197 1. .00 19. .55 c

ANISOU 3219 C ILE B 228 2191 2673 2561 725 -124 - 1039 c

ATOM 3220 O ILE B 228 -4.463 25. ,110 7. .513 1. .00 21. .36 0

ANISOU 3220 O ILE B 228 1842 2907 3367 943 -323 - 1206 0

ATOM 3221 CB ILE B 228 -1.493 24. ,421 5. .976 1. .00 20. .52 c ANISOU 3221 CB ILE B 228 2216 3058 2521 459 -321 - 1082 C

ATOM 3222 CGI ILE B 228 -2.340 23. ,368 5. .236 1. .00 19. , 62 C

ANISOU 3222 CGI ILE B 228 2431 2990 2032 579 -48 - 1317 C

ATOM 3223 CG2 ILE B 228 -0.025 24. ,012 6. .076 1. .00 21. , 25 C

ANISOU 3223 CG2 ILE B 228 2140 3481 2453 298 - 125 -846 C

ATOM 3224 CD1 ILE B 228 -2.069 23. ,304 3. .744 1. .00 18. , 30 C

ANISOU 3224 CD1 ILE B 228 1204 3583 2164 673 84 - 1173 C

ATOM 3225 N GLY B 229 -3.227 26. ,798 6. .700 1. .00 21. ,46 N

ANISOU 3225 N GLY B 229 2318 2878 2958 1132 - 541 -718 N

ATOM 3226 CA GLY B 229 -4.393 27. ,600 6. .361 1. .00 22. , 50 C

ANISOU 3226 CA GLY B 229 2560 2637 3350 1610 - 201 - 1404 C

ATOM 3227 C GLY B 229 -4.802 28. ,613 7. .412 1. .00 21. , 97 C

ANISOU 3227 C GLY B 229 2679 2728 2940 1532 - 424 - 1355 C

ATOM 3228 O GLY B 229 -5.670 29. ,448 7. .151 1. .00 27. , 12 O

ANISOU 3228 O GLY B 229 3186 3593 3522 2073 - 858 - 1173 O

ATOM 3229 N GLY B 230 -4.209 28. ,515 8. .605 1. .00 21. , 40 N

ANISOU 3229 N GLY B 230 2343 2981 2806 563 - 376 - 1462 N

ATOM 3230 CA GLY B 230 -4.431 29. ,499 9. .666 1. .00 22. , 04 C

ANISOU 3230 CA GLY B 230 2263 2906 3203 998 297 - 1344 C

ATOM 3231 C GLY B 230 -3.623 30. ,743 9. .347 1. .00 21. , 33 C

ANISOU 3231 C GLY B 230 2566 2899 2638 1022 -24 -717 C

ATOM 3232 O GLY B 230 -2.623 30. ,658 8. .619 1. .00 21. , 69 O

ANISOU 3232 O GLY B 230 2274 3543 2423 692 - 214 -694 O

ATOM 3233 N PRO B 231 -4.034 31. ,898 9. .889 1. .00 22. ,89 N

ANISOU 3233 N PRO B 231 2888 2502 3304 668 214 -668 N

ATOM 3234 CA PRO B 231 -3.408 33. ,172 9. .509 1. .00 18. , 78 C

ANISOU 3234 CA PRO B 231 2208 2515 2410 671 356 -831 C

ATOM 3235 C PRO B 231 -1.924 33. ,288 9. .851 1. .00 22. , 25 C

ANISOU 3235 C PRO B 231 2325 3069 3057 345 234 -259 C

ATOM 3236 O PRO B 231 -1.237 34. ,119 9. .262 1. .00 23. , 53 O

ANISOU 3236 O PRO B 231 2982 2836 3122 306 401 -146 O

ATOM 3237 CB PRO B 231 -4.228 34. ,219 10. .283 1. .00 21. ,19 C

ANISOU 3237 CB PRO B 231 2274 2678 3098 668 347 - 1240 C

ATOM 3238 CG PRO B 231 -4.923 33. ,464 11. .366 1. .00 24. , 98 c

ANISOU 3238 CG PRO B 231 3359 2404 3728 647 383 -878 c

ATOM 3239 CD PRO B 231 -5.164 32. ,090 10. .820 1. .00 23. , 20 c

ANISOU 3239 CD PRO B 231 3061 2796 2956 415 161 - 1117 c

ATOM 3240 N ASP B 232 -1.437 32. ,461 10. .778 1. .00 21. , 48 N

ANISOU 3240 N ASP B 232 2579 2934 2646 940 183 -856 N

ATOM 3241 CA ASP B 232 -0.037 32. ,526 11. .227 1. .00 25. ,16 C

ANISOU 3241 CA ASP B 232 2649 3249 3660 1027 180 -874 C

ATOM 3242 C ASP B 232 0.801 31. .334 10, .765 1, .00 21. .13 C

ANISOU 3242 C ASP B 232 2506 2961 2559 509 373 - 1009 C

ATOM 3243 O ASP B 232 1.932 31. .153 11, .223 1, .00 25. .87 O

ANISOU 3243 O ASP B 232 2547 3281 3999 317 -9 -993 O

ATOM 3244 CB ASP B 232 0.031 32. .643 12, .760 1, .00 30. .83 c

ANISOU 3244 CB ASP B 232 2900 5164 3651 473 154 - 1174 c

ATOM 3245 CG ASP B 232 -0.649 31. ,467 13. .489 1. .00 41. , 75 c

ANISOU 3245 CG ASP B 232 5238 6168 4457 628 154 211 c

ATOM 3246 OD1 ASP B 232 -1.527 30. ,774 12. .908 1. .00 38. , 52 0

ANISOU 3246 OD1 ASP B 232 6647 4320 3668 1105 820 -969 0

ATOM 3247 OD2 ASP B 232 -0.303 31. ,245 14. .669 1. .00 44. ,81 0

ANISOU 3247 OD2 ASP B 232 4019 7845 5161 1600 -50 873 0

ATOM 3248 N GLN B 233 0.251 30. .527 9, .861 1, .00 20. .53 N

ANISOU 3248 N GLN B 233 2483 2533 2784 406 369 -891 N

ATOM 3249 CA GLN B 233 0.890 29. .278 9, .455 1, .00 19. .27 C

ANISOU 3249 CA GLN B 233 1859 2418 3043 448 70 -667 C

ATOM 3250 C GLN B 233 1.583 29. .446 8, .112 1, .00 21. .54 C

ANISOU 3250 C GLN B 233 2567 2745 2873 588 -84 -404 C

ATOM 3251 O GLN B 233 1.041 30. .080 7, .188 1, .00 20. .99 0

ANISOU 3251 O GLN B 233 1478 3336 3160 937 264 -53 0 ATOM 3252 CB GLN B 233 -0.142 28.,143 9.,382 1.,00 18., 35 C

ANISOU 3252 CB GLN B 233 1878 2667 2425 300 -25 -458 C

ATOM 3253 CG GLN B 233 -0.938 27. ,968 10. ,672 1. ,00 18. , 98 C

ANISOU 3253 CG GLN B 233 1618 3199 2392 118 -72 -592 C

ATOM 3254 CD GLN B 233 -1.770 26. ,707 10. ,679 1. ,00 19. , 17 C

ANISOU 3254 CD GLN B 233 2764 2453 2066 293 -66 -875 C

ATOM 3255 OE1 GLN B 233 -2.763 26. ,616 9. ,960 1. ,00 22. , 33 O

ANISOU 3255 OE1 GLN B 233 2859 3240 2383 459 -151 -994 O

ATOM 3256 NE2 GLN B 233 -1.389 25. ,736 11. ,511 1. ,00 18. , 48 N

ANISOU 3256 NE2 GLN B 233 1842 3088 2089 -10 -317 -555 N

ATOM 3257 N GLU B 234 2.783 28. .884 8. .008 1. .00 19. .81 N

ANISOU 3257 N GLU B 234 1932 2736 2858 -93 -225 -727 N

ATOM 3258 CA GLU B 234 3.579 28. .981 6. .789 1. ,00 21. , 58 C

ANISOU 3258 CA GLU B 234 2508 2331 3359 181 302 -680 C

ATOM 3259 C GLU B 234 4.368 27. .688 6. .584 1. .00 19. .01 C

ANISOU 3259 C GLU B 234 2261 2362 2597 182 115 -645 C

ATOM 3260 O GLU B 234 4.698 26. .983 7. .552 1. .00 18. .64 O

ANISOU 3260 O GLU B 234 2340 2185 2555 346 65 -615 O

ATOM 3261 CB GLU B 234 4.545 30. .175 6. .838 1. .00 18. .11 C

ANISOU 3261 CB GLU B 234 2571 1883 2425 336 -379 -658 C

ATOM 3262 CG GLU B 234 3.883 31. .553 6. .953 1. .00 23. .41 C

ANISOU 3262 CG GLU B 234 3293 2104 3498 676 -110 -489 C

ATOM 3263 CD GLU B 234 4.870 32. .701 6. .872 1. .00 27. .87 C

ANISOU 3263 CD GLU B 234 4144 3262 3182 -232 151 -747 C

ATOM 3264 OE1 GLU B 234 5.745 32. .699 5. .982 1. .00 28. .24 O

ANISOU 3264 OE1 GLU B 234 3957 3340 3431 -328 198 -390 O

ATOM 3265 OE2 GLU B 234 4.770 33. .622 7. .700 1. .00 39. .76 O

ANISOU 3265 OE2 GLU B 234 5791 4063 5252 -1710 827 - 2118 O

ATOM 3266 N PHE B 235 4.655 27. ,373 5. ,324 1. ,00 17. , 28 N

ANISOU 3266 N PHE B 235 2051 2189 2325 -42 8 -384 N

ATOM 3267 CA PHE B 235 5.544 26. .254 5. .025 1. .00 15. .65 C

ANISOU 3267 CA PHE B 235 1509 2433 2002 -49 -44 -344 C

ATOM 3268 C PHE B 235 6.352 26. .466 3. .759 1. .00 17. .28 C

ANISOU 3268 C PHE B 235 1896 2544 2123 379 169 -305 C

ATOM 3269 O PHE B 235 6.058 27. .348 2. .946 1. .00 14. .72 O

ANISOU 3269 O PHE B 235 1670 1899 2023 200 57 -583 O

ATOM 3270 CB PHE B 235 4.777 24. .918 4. .970 1. .00 16. .26 C

ANISOU 3270 CB PHE B 235 1814 2537 1824 -229 -173 -386 C

ATOM 3271 CG PHE B 235 3.950 24. .718 3. .720 1. .00 15. .84 c

ANISOU 3271 CG PHE B 235 1821 2455 1742 -253 -9 -645 c

ATOM 3272 CD1 PHE B 235 4.506 24. ,101 2. ,591 1. ,00 15. , 68 c

ANISOU 3272 CD1 PHE B 235 2003 2012 1941 -110 -239 -965 c

ATOM 3273 CD2 PHE B 235 2.610 25. .110 3. .676 1. .00 18. .81 c

ANISOU 3273 CD2 PHE B 235 1818 2791 2537 -227 -830 -657 c

ATOM 3274 CE1 PHE B 235 3.749 23. .895 1. .440 1. .00 17. .76 c

ANISOU 3274 CE1 PHE B 235 1323 3004 2418 -62 -532 -563 c

ATOM 3275 CE2 PHE B 235 1.852 24. .910 2. .524 1. ,00 19. , 00 c

ANISOU 3275 CE2 PHE B 235 1479 3413 2326 228 -700 -522 c

ATOM 3276 CZ PHE B 235 2.418 24. .302 1. .404 1. .00 18. .43 c

ANISOU 3276 CZ PHE B 235 1553 2842 2607 257 -745 -537 c

ATOM 3277 N GLY B 236 7.383 25. .640 3. .627 1. .00 16. .91 N

ANISOU 3277 N GLY B 236 1675 2565 2185 230 53 -851 N

ATOM 3278 CA GLY B 236 8.174 25. .525 2. .419 1. .00 17. .26 C

ANISOU 3278 CA GLY B 236 2114 2414 2028 -97 297 -462 C

ATOM 3279 C GLY B 236 8.591 24. .068 2. .291 1. .00 15. .99 c

ANISOU 3279 C GLY B 236 1869 2589 1617 36 322 -556 c

ATOM 3280 O GLY B 236 8.324 23. .254 3. .190 1. .00 14. .22 0

ANISOU 3280 O GLY B 236 1465 2128 1808 137 315 -663 0

ATOM 3281 N VAL B 237 9.226 23. ,729 1. ,164 1. ,00 16. , 53 N

ANISOU 3281 N VAL B 237 2008 2620 1651 208 236 -739 N

ATOM 3282 CA VAL B 237 9.601 22. .345 0. .874 1. .00 14. .74 C ANISOU 3282 CA VAL B 237 1464 2418 1716 4 101 -376 C

ATOM 3283 C VAL B 237 10.947 22. .351 0, .154 1, .00 18. .39 C

ANISOU 3283 C VAL B 237 1988 2614 2385 243 721 377 C

ATOM 3284 O VAL B 237 11.204 23. .223 -0. .721 1. .00 17. ,11 O

ANISOU 3284 O VAL B 237 2477 1721 2302 67 347 207 O

ATOM 3285 CB VAL B 237 8.541 21. .628 -0. .016 1. .00 12. , 82 C

ANISOU 3285 CB VAL B 237 922 1746 2201 -27 397 -400 C

ATOM 3286 CGI VAL B 237 8.849 20. .145 -0. .140 1. .00 15. , 90 C

ANISOU 3286 CGI VAL B 237 1853 1963 2222 193 88 -644 C

ATOM 3287 CG2 VAL B 237 7.124 21. .792 0, .581 1, .00 14. .22 C

ANISOU 3287 CG2 VAL B 237 1001 2747 1651 -54 394 -469 C

ATOM 3288 N ASP B 238 11.811 21. .423 0, .551 1, .00 15. .41 N

ANISOU 3288 N ASP B 238 1938 1941 1973 -15 27 -289 N

ATOM 3289 CA ASP B 238 12.995 21. .087 -0. .241 1. .00 17. , 14 C

ANISOU 3289 CA ASP B 238 2058 2321 2133 -172 149 -713 C

ATOM 3290 C ASP B 238 12.794 19. .655 -0. .699 1. .00 15. , 96 C

ANISOU 3290 C ASP B 238 1758 2265 2040 -200 96 -668 C

ATOM 3291 O ASP B 238 12.625 18. .761 0, .129 1, .00 17. .27 O

ANISOU 3291 O ASP B 238 2116 2107 2337 45 294 -595 O

ATOM 3292 CB ASP B 238 14.291 21. .173 0, .583 1, .00 19. .64 C

ANISOU 3292 CB ASP B 238 2191 2888 2381 103 -119 -216 C

ATOM 3293 CG ASP B 238 14.660 22. .593 0, .971 1, .00 25. .24 C

ANISOU 3293 CG ASP B 238 3585 3336 2667 -125 -487 -605 c

ATOM 3294 OD1 ASP B 238 14.263 23. .560 0, .277 1, .00 33. .02 0

ANISOU 3294 OD1 ASP B 238 3745 3236 5562 364 -1276 -313 0

ATOM 3295 OD2 ASP B 238 15.387 22. ,740 1. .975 1. .00 33. , 27 0

ANISOU 3295 OD2 ASP B 238 4171 4513 3956 -42 -1299 - 1835 0

ATOM 3296 N VAL B 239 12.799 19. .432 -2. .007 1. .00 14. , 30 N

ANISOU 3296 N VAL B 239 1413 2129 1890 -48 44 -344 N

ATOM 3297 CA VAL B 239 12.588 18. .077 -2. .534 1. .00 13. , 47 C

ANISOU 3297 CA VAL B 239 1178 2310 1628 -9 254 -636 C

ATOM 3298 C VAL B 239 13.937 17. .407 -2. .777 1. .00 13. , 75 C

ANISOU 3298 C VAL B 239 1628 1970 1626 406 54 -634 C

ATOM 3299 O VAL B 239 14.737 17. .911 -3. .559 1. .00 16. , 25 O

ANISOU 3299 O VAL B 239 1906 2312 1955 248 38 -119 0

ATOM 3300 CB VAL B 239 11.759 18. .095 -3. .840 1. .00 13. , 12 c

ANISOU 3300 CB VAL B 239 1587 2010 1386 9 332 -661 c

ATOM 3301 CGI VAL B 239 11.478 16. .675 -4. .330 1. .00 14. ,41 c

ANISOU 3301 CGI VAL B 239 1645 1720 2110 149 362 -429 c

ATOM 3302 CG2 VAL B 239 10.459 18. .871 -3. .646 1. .00 16. , 67 c

ANISOU 3302 CG2 VAL B 239 1646 2360 2326 353 -304 -423 c

ATOM 3303 N GLY B 240 14.180 16. .287 -2. .097 1. .00 15. , 18 N

ANISOU 3303 N GLY B 240 1746 2054 1966 488 32 -530 N

ATOM 3304 CA GLY B 240 15.428 15. .520 -2. .247 1. .00 14. , 58 C

ANISOU 3304 CA GLY B 240 1574 2285 1678 424 385 -223 C

ATOM 3305 C GLY B 240 15.464 14. .726 -3. .539 1. .00 15. , 42 C

ANISOU 3305 C GLY B 240 1509 2287 2060 328 -158 -467 C

ATOM 3306 O GLY B 240 14.424 14. ,536 -4. .164 1. .00 14. , 14 0

ANISOU 3306 O GLY B 240 1300 1678 2394 418 -201 -515 0

ATOM 3307 N PRO B 241 16.662 14. .255 -3. .960 1. .00 14. , 24 N

ANISOU 3307 N PRO B 241 1405 2084 1918 266 -126 -447 N

ATOM 3308 CA PRO B 241 16.723 13. .505 -5. .219 1. .00 14. , 78 C

ANISOU 3308 CA PRO B 241 1548 2228 1837 252 -118 -401 C

ATOM 3309 C PRO B 241 16.058 12. .128 -5. .103 1. .00 14. , 74 C

ANISOU 3309 C PRO B 241 1628 2159 1813 253 -10 -517 C

ATOM 3310 O PRO B 241 16.039 11. .534 -4. .028 1. .00 16. , 80 O

ANISOU 3310 O PRO B 241 1947 2328 2108 42 476 -343 O

ATOM 3311 CB PRO B 241 18.238 13. .347 -5. .467 1. .00 17. , 96 C

ANISOU 3311 CB PRO B 241 1793 2800 2231 383 440 -459 c

ATOM 3312 CG PRO B 241 18.861 13. ,467 -4. .126 1. .00 19. ,09 c

ANISOU 3312 CG PRO B 241 2290 2527 2434 369 201 -676 c ATOM 3313 CD PRO B 241 17.999 14..423 -3..344 1..00 15..44 C

ANISOU 3313 CD PRO B 241 1107 2289 2468 272 20 332 C

ATOM 3314 N VAL B 242 15.492 11. .634 -6. .197 1. .00 14. .58 N

ANISOU 3314 N VAL B 242 1361 2160 2019 -337 243 552 N

ATOM 3315 CA VAL B 242 15.010 10. .271 -6. .216 1. .00 13. .96 C

ANISOU 3315 CA VAL B 242 1439 1915 1947 -59 261 382 C

ATOM 3316 C VAL B 242 16.152 9. .343 -6. .622 1. .00 12. .78 C

ANISOU 3316 C VAL B 242 1446 1700 1710 -101 190 302 C

ATOM 3317 O VAL B 242 16.836 9. .598 -7. .607 1. .00 13. .80 O

ANISOU 3317 O VAL B 242 1201 2028 2012 274 515 472 O

ATOM 3318 CB VAL B 242 13.727 10. .114 -7. .093 1. .00 15. .32 C

ANISOU 3318 CB VAL B 242 1480 2190 2149 10 118 223 C

ATOM 3319 CGI VAL B 242 13.980 10. .565 -8. .528 1. .00 16. .15 C

ANISOU 3319 CGI VAL B 242 1732 2285 2119 93 253 301 c

ATOM 3320 CG2 VAL B 242 13.204 8. .684 -7. .031 1. .00 15. .62 c

ANISOU 3320 CG2 VAL B 242 1313 2237 2384 -46 272 545 c

ATOM 3321 N CYS B 243 16.388 8. ,306 -5. .831 1. .00 12. .33 N

ANISOU 3321 N CYS B 243 1227 1675 1780 125 100 270 N

ATOM 3322 CA CYS B 243 17.542 7. .430 -6. .039 1. .00 12. .63 C

ANISOU 3322 CA CYS B 243 1351 1384 2062 97 -30 293 C

ATOM 3323 C CYS B 243 17.091 6. .014 -6. .355 1. .00 13. .28 C

ANISOU 3323 C CYS B 243 1655 1480 1908 -106 - 388 209 C

ATOM 3324 O CYS B 243 16.276 5. .451 -5. .626 1. .00 17. .41 O

ANISOU 3324 O CYS B 243 2285 2238 2088 -189 125 136 O

ATOM 3325 CB CYS B 243 18.441 7. .435 -4. .808 1. .00 17. .41 c

ANISOU 3325 CB CYS B 243 2047 2277 2291 -34 - 500 3 c

ATOM 3326 SG CYS B 243 19.273 9. .019 -4. .490 1. .00 21. .62 s

ANISOU 3326 SG CYS B 243 2662 2748 2802 -471 8 497 s

ATOM 3327 N PHE B 244 17.612 5. .459 -7. .450 1. .00 14. .04 N

ANISOU 3327 N PHE B 244 1650 1630 2052 180 - 241 -36 N

ATOM 3328 CA PHE B 244 17.230 4. .125 -7. .922 1. .00 13. .83 C

ANISOU 3328 CA PHE B 244 1633 1839 1782 108 - 212 268 C

ATOM 3329 C PHE B 244 18.420 3. .196 -7. .838 1. .00 15. .35 C

ANISOU 3329 C PHE B 244 1844 1902 2084 184 - 408 150 C

ATOM 3330 O PHE B 244 19.555 3. .613 -8. .109 1. .00 16. .90 O

ANISOU 3330 O PHE B 244 1620 2345 2455 461 - 212 -24 0

ATOM 3331 CB PHE B 244 16.768 4. .180 -9. .388 1. .00 12. .55 c

ANISOU 3331 CB PHE B 244 1038 1821 1908 103 - 306 117 c

ATOM 3332 CG PHE B 244 15.554 5. .030 -9. .605 1. .00 13. .39 c

ANISOU 3332 CG PHE B 244 1525 1962 1599 442 - 493 -76 c

ATOM 3333 CD1 PHE B 244 14.280 4. .487 -9. .431 1. .00 13. .85 c

ANISOU 3333 CD1 PHE B 244 1556 2249 1458 500 -20 15 c

ATOM 3334 CD2 PHE B 244 15.671 6. .367 -9. .986 1. .00 14. .31 c

ANISOU 3334 CD2 PHE B 244 1751 1989 1696 344 -60 159 c

ATOM 3335 CE1 PHE B 244 13.138 5. ,270 -9. .628 1. .00 14. .05 c

ANISOU 3335 CE1 PHE B 244 1664 2040 1631 514 - 144 190 c

ATOM 3336 CE2 PHE B 244 14.521 7. .157 -10. .196 1. .00 15. .76 c

ANISOU 3336 CE2 PHE B 244 1104 2922 1962 168 - 201 492 c

ATOM 3337 CZ PHE B 244 13.255 6. .603 -10. .014 1. .00 14. .73 c

ANISOU 3337 CZ PHE B 244 1701 2210 1683 -75 432 313 c

ATOM 3338 N LEU B 245 18.159 1. .940 -7. .493 1. .00 16. .88 N

ANISOU 3338 N LEU B 245 2195 1803 2415 97 - 204 -41 N

ATOM 3339 CA LEU B 245 19.194 0. .925 -7. .444 1. .00 17. .59 C

ANISOU 3339 CA LEU B 245 2149 2113 2419 160 - 180 130 c

ATOM 3340 C LEU B 245 19.056 -0. ,033 -8. .639 1. .00 21. .98 c

ANISOU 3340 C LEU B 245 2956 2369 3024 -41 - 377 522 c

ATOM 3341 O LEU B 245 19.699 0. .146 -9. .697 1. .00 23. .92 0

ANISOU 3341 O LEU B 245 3666 2724 2699 100 - 591 393 0

ATOM 3342 CB LEU B 245 19.179 0. .173 -6. .097 1. .00 16. .57 c

ANISOU 3342 CB LEU B 245 2286 1416 2594 385 15 -85 c

ATOM 3343 CG LEU B 245 20.328 -0. ,826 -5. .881 1. .00 15. .49 c ANISOU 3343 CG LEU B 245 1596 2267 2019 332 45 -32 C

ATOM 3344 CD1 LEU B 245 21.695 -0. ,143 -5. .959 1. .00 16. .60 C

ANISOU 3344 CD1 LEU B 245 1859 2110 2337 44 -114 -443 C

ATOM 3345 CD2 LEU B 245 20.159 -1. ,603 -4. .575 1. .00 17. .11 C

ANISOU 3345 CD2 LEU B 245 2369 2175 1956 640 -186 -48 C

ATOM 3346 OXT LEU B 245 18.305 -1. ,005 -8. .582 1. .00 23. .10 O

ANISOU 3346 OXT LEU B 245 3080 2465 3231 -302 -785 -197 O

TER 3347 LEU B 245

ATOM 3348 N SER C 29 28.066 -9. ,552 -32. .878 1. .00 37. .84 N

ANISOU 3348 N SER C 29 3987 5256 5135 677 1780 1790 N

ATOM 3349 CA SER C 29 26.717 -10. ,123 -32. .561 1. .00 37. .75 C

ANISOU 3349 CA SER C 29 4687 5578 4077 -330 1304 1668 C

ATOM 3350 C SER C 29 26.778 -11. ,073 -31. .358 1. .00 31. .54 C

ANISOU 3350 C SER C 29 4072 4966 2944 350 987 659 C

ATOM 3351 O SER C 29 27.673 -11. ,910 -31. .295 1. .00 29. .58 O

ANISOU 3351 O SER C 29 3269 4575 3393 -244 510 283 O

ATOM 3352 CB SER C 29 26.161 -10. ,867 -33. .782 1. .00 37. .93 C

ANISOU 3352 CB SER C 29 3760 6854 3798 271 1864 822 C

ATOM 3353 OG SER C 29 25.035 -11. ,661 -33. .445 1. .00 48. .20 0

ANISOU 3353 OG SER C 29 6095 6516 5700 -2009 45 1102 0

ATOM 3354 N PRO C 30 25.815 -10. ,963 -30. .412 1. .00 31. .95 N

ANISOU 3354 N PRO C 30 4354 4190 3594 948 1412 742 N

ATOM 3355 CA PRO C 30 25.803 -11. ,877 -29. .259 1. .00 29. .30 C

ANISOU 3355 CA PRO C 30 3946 4451 2736 772 796 355 C

ATOM 3356 C PRO C 30 25.707 -13. ,336 -29. .692 1. .00 29. .87 C

ANISOU 3356 C PRO C 30 4301 4196 2848 320 598 823 C

ATOM 3357 O PRO C 30 25.185 -13. ,627 -30. .765 1. .00 30. .93 O

ANISOU 3357 O PRO C 30 4715 4836 2199 222 919 846 O

ATOM 3358 CB PRO C 30 24.536 -11. ,477 -28. .490 1. .00 28. .25 C

ANISOU 3358 CB PRO C 30 3661 4598 2473 224 992 851 c

ATOM 3359 CG PRO C 30 24.248 -10. ,070 -28. .918 1. .00 27. .91 c

ANISOU 3359 CG PRO C 30 3006 4472 3127 721 2099 720 c

ATOM 3360 CD PRO C 30 24.705 -9. ,990 -30. .354 1. .00 30. .38 c

ANISOU 3360 CD PRO C 30 3595 5221 2724 1026 1662 393 c

ATOM 3361 N ASP c 31 26.223 -14. ,241 -28. .870 1. .00 25. .85 N

ANISOU 3361 N ASP c 31 3438 3628 2753 252 1329 759 N

ATOM 3362 CA ASP c 31 26.182 -15. ,662 -29. .193 1. .00 27. .67 C

ANISOU 3362 CA ASP c 31 3791 3461 3260 207 1023 938 C

ATOM 3363 C ASP c 31 25.886 -16. ,547 -27. .973 1. .00 22. .03 C

ANISOU 3363 C ASP c 31 2886 2772 2711 236 736 428 C

ATOM 3364 O ASP c 31 25.951 -17. ,771 -28. .063 1. .00 24. .00 O

ANISOU 3364 O ASP c 31 3249 2790 3079 405 705 120 0

ATOM 3365 CB ASP c 31 27.489 -16. ,097 -29. .867 1. .00 28. .49 c

ANISOU 3365 CB ASP c 31 3875 4253 2695 -542 1558 1127 c

ATOM 3366 CG ASP c 31 28.707 -15. ,993 -28. .934 1. .00 32. .31 c

ANISOU 3366 CG ASP c 31 3342 4968 3964 715 1298 1213 c

ATOM 3367 OD1 ASP c 31 28.569 -15. ,635 -27. .738 1. .00 26. .43 0

ANISOU 3367 OD1 ASP c 31 2150 3840 4051 487 1420 998 0

ATOM 3368 OD2 ASP c 31 29.820 -16. ,270 -29. .405 1. .00 42. .46 0

ANISOU 3368 OD2 ASP c 31 4447 6011 5675 987 2790 1309 0

ATOM 3369 N GLY c 32 25.580 -15. ,926 -26. .835 1. .00 20. .65 N

ANISOU 3369 N GLY c 32 2837 2433 2576 234 586 547 N

ATOM 3370 CA GLY c 32 25.271 -16. ,663 -25. .608 1. .00 18. .26 C

ANISOU 3370 CA GLY c 32 2907 1760 2270 72 283 249 C

ATOM 3371 C GLY c 32 26.460 -17. ,180 -24. .796 1. .00 15. .78 C

ANISOU 3371 C GLY c 32 2083 1482 2429 -30 666 188 C

ATOM 3372 O GLY c 32 26.283 -17. ,951 -23. .846 1. .00 17. .88 0

ANISOU 3372 O GLY c 32 2510 1978 2303 114 327 432 0

ATOM 3373 N SER c 33 27.678 -16. ,785 -25. .162 1. .00 18. .26 N

ANISOU 3373 N SER c 33 1829 2473 2634 308 636 510 N

ATOM 3374 CA SER c 33 28.862 -17. ,137 -24. .358 1. .00 19. .20 C ANISOU 3374 CA SER C 33 1843 2710 2742 223 487 417 C

ATOM 3375 C SER C 33 28.930 -16. .123 -23. .230 1. .00 18. .55 C

ANISOU 3375 C SER C 33 1853 2251 2942 369 87 475 C

ATOM 3376 O SER C 33 28.315 -15. .056 -23. .315 1. .00 17. .58 O

ANISOU 3376 O SER C 33 1719 2078 2882 281 296 49 O

ATOM 3377 CB SER C 33 30.134 -17. .061 -25. .206 1. .00 23. .22 C

ANISOU 3377 CB SER C 33 2429 3080 3313 69 1102 386 C

ATOM 3378 OG SER C 33 30.264 -15. .758 -25. .769 1. .00 25. .35 O

ANISOU 3378 OG SER C 33 2245 2929 4457 26 959 547 O

ATOM 3379 N ARG C 34 29.668 -16. .448 -22. .174 1. .00 19. .68 N

ANISOU 3379 N ARG C 34 2192 2731 2554 52 103 221 N

ATOM 3380 CA ARG C 34 29.791 -15. .550 -21. .033 1. .00 17. .57 C

ANISOU 3380 CA ARG C 34 1477 2874 2322 258 0 318 C

ATOM 3381 C ARG C 34 30.272 -14. .158 -21. .439 1. .00 19. .19 C

ANISOU 3381 C ARG C 34 1744 2745 2800 361 -4 215 C

ATOM 3382 O ARG C 34 29.747 -13. .158 -20. .949 1. .00 21. .37 O

ANISOU 3382 O ARG C 34 1680 2980 3459 340 296 80 O

ATOM 3383 CB ARG C 34 30.684 -16. .173 -19. .951 1. .00 20. .28 C

ANISOU 3383 CB ARG C 34 1507 3178 3018 824 -129 436 C

ATOM 3384 CG ARG C 34 30.654 -15. .440 -18. .607 1. .00 26. .00 c

ANISOU 3384 CG ARG C 34 2758 3930 3189 655 -427 253 c

ATOM 3385 CD ARG c 34 31.650 -16. .011 -17. .604 1. .00 30. .27 c

ANISOU 3385 CD ARG c 34 2910 3734 4857 190 -918 1472 c

ATOM 3386 NE ARG c 34 32.940 -16. .285 -18. .239 1. .00 38. .62 N

ANISOU 3386 NE ARG c 34 3700 4827 6146 723 -425 895 N

ATOM 3387 CZ ARG c 34 33.896 -15. .384 -18. .465 1. .00 39. .10 C

ANISOU 3387 CZ ARG c 34 3935 5113 5807 499 -556 1237 C

ATOM 3388 NH1 ARG c 34 33.748 -14. .117 -18. .098 1. .00 40. .56 N

ANISOU 3388 NH1 ARG c 34 4142 5259 6010 538 -348 968 N

ATOM 3389 NH2 ARG c 34 35.015 -15. .758 -19. .064 1. .00 46. .00 N

ANISOU 3389 NH2 ARG c 34 4401 6635 6442 107 343 1228 N

ATOM 3390 N LYS c 35 31.249 -14. .095 -22. .347 1. .00 19. .91 N

ANISOU 3390 N LYS c 35 1537 2936 3091 87 11 392 N

ATOM 3391 CA LYS c 35 31.823 -12. .825 -22. .778 1. .00 22. .08 C

ANISOU 3391 CA LYS c 35 2137 2602 3650 369 392 284 C

ATOM 3392 C LYS c 35 30.927 -12. .047 -23. .764 1. .00 21. .07 C

ANISOU 3392 C LYS c 35 1727 2524 3752 -130 169 236 C

ATOM 3393 O LYS c 35 31.107 -10. .850 -23. .961 1. .00 25. .18 O

ANISOU 3393 O LYS c 35 2704 2587 4274 -278 -216 525 O

ATOM 3394 CB LYS c 35 33.233 -13. .045 -23. .352 1. .00 25. .17 C

ANISOU 3394 CB LYS c 35 1624 3058 4878 560 79 690 C

ATOM 3395 CG LYS c 35 34.288 -13. .326 -22. .291 1. .00 29. .41 C

ANISOU 3395 CG LYS c 35 3484 2702 4986 1479 -404 925 C

ATOM 3396 N ASN c 36 29.953 -12. .730 -24. .359 1. .00 18. .96 N

ANISOU 3396 N ASN c 36 1384 2995 2823 -47 500 -61 N

ATOM 3397 CA ASN c 36 29.112 -12. .151 -25. .389 1. .00 21. .65 C

ANISOU 3397 CA ASN c 36 1814 3062 3351 71 457 328 C

ATOM 3398 C ASN c 36 27.654 -12. .647 -25. .238 1. .00 17. .56 C

ANISOU 3398 C ASN c 36 1772 2373 2525 181 429 127 C

ATOM 3399 O ASN c 36 27.116 -13. .299 -26. .147 1. .00 17. .94 O

ANISOU 3399 O ASN c 36 2052 2315 2447 -39 242 446 O

ATOM 3400 CB ASN c 36 29.699 -12. .552 -26. .748 1. .00 24. .60 C

ANISOU 3400 CB ASN c 36 2791 3189 3366 370 473 81 C

ATOM 3401 CG ASN c 36 29.150 -11. .741 -27. .897 1. .00 29. .29 C

ANISOU 3401 CG ASN c 36 3375 4261 3491 576 321 263 c

ATOM 3402 OD1 ASN c 36 28.483 -10. .733 -27. .699 1. .00 32. .59 0

ANISOU 3402 OD1 ASN c 36 3126 4149 5105 227 1064 410 0

ATOM 3403 ND2 ASN c 36 29.443 -12. .182 -29. .123 1. .00 38. .30 N

ANISOU 3403 ND2 ASN c 36 3559 6296 4695 942 2018 -467 N

ATOM 3404 N PRO c 37 27.010 -12. .347 -24. .084 1. .00 16. .71 N

ANISOU 3404 N PRO c 37 2002 2156 2191 228 17 -44 N ATOM 3405 CA PRO C 37 25.668 -12..891 -23..798 1..00 16..41 C

ANISOU 3405 CA PRO C 37 2000 2191 2043 134 109 ^■237 C

ATOM 3406 C PRO C 37 24.579 -12. .350 -24. .723 1. .00 16. .06 C

ANISOU 3406 C PRO C 37 2045 1905 2151 -49 -33 ^■243 C

ATOM 3407 O PRO C 37 24.688 -11. .217 -25. .199 1. .00 16. .94 O

ANISOU 3407 O PRO C 37 1991 2323 2122 300 416 294 O

ATOM 3408 CB PRO C 37 25.383 -12. .400 -22. .367 1. .00 15. .40 C

ANISOU 3408 CB PRO C 37 1883 1908 2061 -35 134 ^■271 C

ATOM 3409 CG PRO C 37 26.248 -11. .187 -22. .208 1. .00 15. .61 C

ANISOU 3409 CG PRO C 37 1232 2244 2455 -89 315 ^■206 C

ATOM 3410 CD PRO C 37 27.513 -11. .530 -22. .962 1. .00 15. .35 C

ANISOU 3410 CD PRO C 37 1491 2125 2216 283 287 ^■221 C

ATOM 3411 N ALA C 38 23.530 -13. .147 -24. .955 1. .00 15. .33 N

ANISOU 3411 N ALA C 38 1465 2194 2165 119 - 209 43 N

ATOM 3412 CA ALA C 38 22.360 -12. .664 -25. .691 1. .00 15. .40 C

ANISOU 3412 CA ALA C 38 1598 2159 2094 513 -36 ^■137 C

ATOM 3413 C ALA C 38 21.402 -12. .067 -24. .661 1. .00 14. .80 C

ANISOU 3413 C ALA C 38 1443 1773 2408 373 74 ^■170 C

ATOM 3414 O ALA C 38 21.584 -12. .258 -23. .463 1. .00 17. .28 O

ANISOU 3414 O ALA C 38 1848 2195 2521 524 188 12 O

ATOM 3415 CB ALA c 38 21.697 -13. .801 -26. .429 1. .00 16. .87 C

ANISOU 3415 CB ALA c 38 2087 2607 1713 -103 370 ^■166 C

ATOM 3416 N ARG c 39 20.388 -11. .340 -25. .109 1. .00 13. .93 N

ANISOU 3416 N ARG c 39 1471 1540 2281 343 278 63 N

ATOM 3417 CA ARG c 39 19.496 -10. .701 -24. .144 1. .00 12. .78 C

ANISOU 3417 CA ARG c 39 1728 1200 1924 458 58 84 C

ATOM 3418 C ARG c 39 18.628 -11. .727 -23. .400 1. .00 14. .04 C

ANISOU 3418 C ARG c 39 1814 1742 1777 41 22 -48 C

ATOM 3419 O ARG c 39 18.344 -11. .569 -22. .207 1. .00 12. .37 O

ANISOU 3419 O ARG c 39 1322 1718 1657 305 - 139 237 O

ATOM 3420 CB ARG c 39 18.635 -9. .641 -24. .805 1. .00 12. .67 C

ANISOU 3420 CB ARG c 39 1181 1595 2038 660 - 118 ^■228 C

ATOM 3421 CG ARG c 39 18.068 -8. .720 -23. .758 1. .00 12. .18 c

ANISOU 3421 CG ARG c 39 1262 1357 2006 728 -76 -72 c

ATOM 3422 CD ARG c 39 17.251 -7. .571 -24. .322 1. .00 13. .43 c

ANISOU 3422 CD ARG c 39 1822 1562 1718 961 -24 30 c

ATOM 3423 NE ARG c 39 17.082 -6. .642 -23. .210 1. .00 13. .30 N

ANISOU 3423 NE ARG c 39 1290 2023 1740 582 126 ^■203 N

ATOM 3424 CZ ARG c 39 16.554 -5. .436 -23. .294 1. .00 14. .07 C

ANISOU 3424 CZ ARG c 39 1587 2082 1675 696 461 82 C

ATOM 3425 NH1 ARG c 39 16.037 -5. .012 -24. .453 1. .00 15. .77 N

ANISOU 3425 NH1 ARG c 39 2125 2115 1750 251 172 234 N

ATOM 3426 NH2 ARG c 39 16.497 -4. .680 -22. .196 1. .00 15. .53 N

ANISOU 3426 NH2 ARG c 39 1853 2631 1417 480 39 32 N

ATOM 3427 N ASN c 40 18.214 -12. .768 -24. .125 1. .00 13. .51 N

ANISOU 3427 N ASN c 40 1873 1400 1860 121 81 82 N

ATOM 3428 CA ASN c 40 17.477 -13. .885 -23. .561 1. .00 11. .85 C

ANISOU 3428 CA ASN c 40 1026 1523 1951 225 -4 103 C

ATOM 3429 C ASN c 40 17.568 -15. .078 -24. .516 1. .00 12. .56 C

ANISOU 3429 C ASN c 40 1339 1569 1862 -42 - 156 114 C

ATOM 3430 O ASN c 40 18.119 -14. .969 -25. .614 1. .00 12. .16 O

ANISOU 3430 O ASN c 40 1426 1428 1766 -7 - 233 78 O

ATOM 3431 CB ASN c 40 16.005 -13. .508 -23. .265 1. .00 12. .45 C

ANISOU 3431 CB ASN c 40 1232 1818 1680 598 80 383 C

ATOM 3432 CG ASN c 40 15.232 -13. .102 -24. .505 1. .00 14. .88 C

ANISOU 3432 CG ASN c 40 1607 2307 1736 473 - 299 88 C

ATOM 3433 OD1 ASN c 40 15.765 -13. .073 -25. .610 1. .00 13. .67 O

ANISOU 3433 OD1 ASN c 40 1693 1659 1840 472 - 179 ^■170 O

ATOM 3434 ND2 ASN c 40 13.971 -12. .752 -24. .314 1. .00 17. .81 N

ANISOU 3434 ND2 ASN c 40 1888 2480 2396 620 283 ^■183 N

ATOM 3435 N CYS c 41 17.027 -16. .215 -24. .110 1. .00 13. .20 N ANISOU 3435 N CYS C 41 1411 1575 2026 -118 -141 141 N

ATOM 3436 CA CYS C 41 17.067 -17. ,406 -24. .963 1. .00 13. .46 C

ANISOU 3436 CA CYS C 41 1600 1840 1672 -173 -170 139 C

ATOM 3437 C CYS C 41 16.192 -17. ,267 -26. .225 1. .00 14. .39 C

ANISOU 3437 C CYS C 41 1611 2104 1750 -136 -209 184 C

ATOM 3438 O CYS C 41 16.488 -17. ,868 -27. .252 1. .00 16. .80 O

ANISOU 3438 O CYS C 41 2305 2022 2054 158 -84 143 O

ATOM 3439 CB CYS C 41 16.634 -18. ,628 -24. .164 1. .00 12. .54 c

ANISOU 3439 CB CYS C 41 1601 1633 1529 10 -92 72 c

ATOM 3440 SG CYS C 41 17.730 -18. ,992 -22. .792 1. .00 11. .92 s

ANISOU 3440 SG CYS C 41 1505 1523 1500 -4 -38 -28 s

ATOM 3441 N ARG C 42 15.125 -16. ,474 -26. .161 1. .00 13. .56 N

ANISOU 3441 N ARG C 42 1414 2156 1580 -169 -306 187 N

ATOM 3442 CA ARG C 42 14.284 -16. ,349 -27. .345 1. .00 16. .05 C

ANISOU 3442 CA ARG C 42 1557 2704 1834 320 -409 457 C

ATOM 3443 C ARG C 42 15.078 -15. ,657 -28. .463 1. .00 16. .33 C

ANISOU 3443 C ARG C 42 2031 2425 1745 62 -329 187 C

ATOM 3444 O ARG C 42 15.016 -16. ,067 -29. .625 1. .00 18. .25 O

ANISOU 3444 O ARG C 42 2208 2947 1779 283 -492 148 O

ATOM 3445 CB ARG C 42 12.965 -15. ,637 -27. .052 1. .00 17. .87 C

ANISOU 3445 CB ARG C 42 1430 2883 2474 472 -1098 41 c

ATOM 3446 CG ARG C 42 12.004 -15. ,766 -28. .226 1. .00 20. .13 c

ANISOU 3446 CG ARG C 42 1568 3632 2448 465 -1212 641 c

ATOM 3447 CD ARG c 42 10.647 -15. ,130 -28. .014 1. .00 26. .00 c

ANISOU 3447 CD ARG c 42 2334 3642 3901 1053 -598 440 c

ATOM 3448 NE ARG c 42 9.956 -15. ,165 -29. .295 1. .00 38. .82 N

ANISOU 3448 NE ARG c 42 3453 5927 5367 440 -1858 462 N

ATOM 3449 CZ ARG c 42 9.152 -16. ,143 -29. .714 1. .00 42. .22 C

ANISOU 3449 CZ ARG c 42 4139 5662 6240 -530 -1168 1173 C

ATOM 3450 NH1 ARG c 42 8.880 -17. ,188 -28. .943 1. .00 41. .90 N

ANISOU 3450 NH1 ARG c 42 6111 5677 4131 -568 -606 502 N

ATOM 3451 NH2 ARG c 42 8.605 -16. ,066 -30. .918 1. .00 50. .36 N

ANISOU 3451 NH2 ARG c 42 5472 7324 6336 1025 -1342 513 N

ATOM 3452 N ASP c 43 15.856 -14. ,632 -28. .107 1. .00 15. .57 N

ANISOU 3452 N ASP c 43 1640 2202 2074 304 -205 136 N

ATOM 3453 CA ASP c 43 16.735 -13. ,998 -29. .083 1. .00 16. .72 C

ANISOU 3453 CA ASP c 43 2168 2078 2106 175 3 30 C

ATOM 3454 C ASP c 43 17.741 -14. ,987 -29. .662 1. .00 17. .02 C

ANISOU 3454 C ASP c 43 2053 2531 1881 415 47 267 C

ATOM 3455 O ASP c 43 18.006 -14. ,973 -30. .865 1. .00 21. .50 O

ANISOU 3455 O ASP c 43 2792 3250 2126 586 720 252 O

ATOM 3456 CB ASP c 43 17.463 -12. ,811 -28. .475 1. .00 17. .61 C

ANISOU 3456 CB ASP c 43 2532 1898 2261 65 99 50 C

ATOM 3457 CG ASP c 43 16.622 -11. ,555 -28. .473 1. .00 16. .78 C

ANISOU 3457 CG ASP c 43 2216 1651 2507 -212 -288 -26 C

ATOM 3458 OD1 ASP c 43 15.416 -11. ,616 -28. .819 1. .00 16. .51 O

ANISOU 3458 OD1 ASP c 43 2088 1947 2236 192 -150 80 O

ATOM 3459 OD2 ASP c 43 17.177 -10. ,497 -28. .124 1. .00 18. .07 O

ANISOU 3459 OD2 ASP c 43 3076 1382 2408 -318 64 -72 O

ATOM 3460 N LEU c 44 18.289 -15. ,858 -28. .825 1. .00 15. .08 N

ANISOU 3460 N LEU c 44 1938 2205 1584 606 422 126 N

ATOM 3461 CA LEU c 44 19.233 -16. ,861 -29. .338 1. .00 17. .24 C

ANISOU 3461 CA LEU c 44 2176 2508 1867 1172 284 519 C

ATOM 3462 C LEU c 44 18.541 -17. ,798 -30. .319 1. .00 20. .82 C

ANISOU 3462 C LEU c 44 2861 3078 1969 824 337 233 C

ATOM 3463 O LEU c 44 19.064 -18. ,077 -31. .400 1. .00 21. .91 O

ANISOU 3463 O LEU c 44 2692 3393 2238 1425 453 349 O

ATOM 3464 CB LEU c 44 19.858 -17. ,674 -28. .208 1. .00 19. .58 C

ANISOU 3464 CB LEU c 44 2436 2957 2045 532 -113 925 C

ATOM 3465 CG LEU c 44 21.031 -17. ,034 -27. .488 1. .00 21. .39 c

ANISOU 3465 CG LEU c 44 2472 3444 2208 -267 481 969 c ATOM 3466 CD1 LEU C 44 21.398 -17.,848 -26..244 1..00 19..55 C

ANISOU 3466 CD1 LEU C 44 1875 2713 2837 -11 339 1031 C

ATOM 3467 CD2 LEU C 44 22.220 -16. ,851 -28. .434 1. .00 19. .23 C

ANISOU 3467 CD2 LEU C 44 1912 3027 2367 37 420 224 C

ATOM 3468 N LYS C 45 17.354 -18. ,260 -29. .943 1. .00 20. .10 N

ANISOU 3468 N LYS C 45 2634 2875 2128 637 -81 -108 N

ATOM 3469 CA LYS C 45 16.600 -19. ,198 -30. .760 1. .00 21. .41 C

ANISOU 3469 CA LYS C 45 3066 3327 1742 603 -32 -314 C

ATOM 3470 C LYS C 45 16.407 -18. ,649 -32. .168 1. .00 24. .44 C

ANISOU 3470 C LYS C 45 3798 3599 1887 1107 396 -56 C

ATOM 3471 O LYS C 45 16.633 -19. ,362 -33. .150 1. .00 31. .04 O

ANISOU 3471 O LYS c 45 4640 5044 2110 2031 334 -564 O

ATOM 3472 CB LYS c 45 15.247 -19. ,522 -30. .110 1. .00 20. .63 C

ANISOU 3472 CB LYS c 45 2746 3280 1812 431 -396 -185 C

ATOM 3473 CG LYS c 45 14.260 -20. ,230 -31. .027 1. .00 20. .33 C

ANISOU 3473 CG LYS c 45 2949 3232 1544 -25 -26 -232 C

ATOM 3474 CD LYS c 45 12.989 -20. ,624 -30. .291 1. .00 18. .68 c

ANISOU 3474 CD LYS c 45 2777 2931 1388 -89 -440 172 c

ATOM 3475 CE LYS c 45 11.951 -21. ,251 -31. .217 1. .00 24. .33 c

ANISOU 3475 CE LYS c 45 3811 3194 2238 64 -948 -884 c

ATOM 3476 NZ LYS c 45 12.367 -22. ,569 -31. .789 1. .00 25. .22 N

ANISOU 3476 NZ LYS c 45 5279 2124 2180 -701 -1244 -365 N

ATOM 3477 N PHE c 46 16.012 -17. ,381 -32. .267 1. .00 21. .60 N

ANISOU 3477 N PHE c 46 3215 3393 1597 722 -307 157 N

ATOM 3478 CA PHE c 46 15.681 -16. ,805 -33. .566 1. .00 24. .99 C

ANISOU 3478 CA PHE c 46 3771 4040 1684 1117 23 443 C

ATOM 3479 C PHE c 46 16.869 -16. ,261 -34. .339 1. .00 24. .82 C

ANISOU 3479 C PHE c 46 3783 3585 2061 678 -50 432 C

ATOM 3480 O PHE c 46 16.948 -16. ,441 -35. .554 1. .00 26. .09 O

ANISOU 3480 O PHE c 46 3898 3845 2166 974 -427 28 O

ATOM 3481 CB PHE c 46 14.530 -15. ,812 -33. .448 1. .00 25. .19 C

ANISOU 3481 CB PHE c 46 2757 4313 2500 834 -414 690 C

ATOM 3482 CG PHE c 46 13.201 -16. ,485 -33. .269 1. .00 29. .15 C

ANISOU 3482 CG PHE c 46 2789 4955 3329 702 -181 -170 C

ATOM 3483 CD1 PHE c 46 12.431 -16. ,860 -34. .381 1. .00 36. .21 C

ANISOU 3483 CD1 PHE c 46 4133 6217 3407 956 -775 -452 c

ATOM 3484 CD2 PHE c 46 12.728 -16. ,783 -31. .992 1. .00 27. .24 c

ANISOU 3484 CD2 PHE c 46 2717 4758 2872 303 -965 -12 c

ATOM 3485 CE1 PHE c 46 11.206 -17. ,498 -34. .215 1. .00 41. .03 c

ANISOU 3485 CE1 PHE c 46 4738 6973 3878 280 -501 -765 c

ATOM 3486 CE2 PHE c 46 11.512 -17. ,428 -31. .820 1. .00 29. .89 c

ANISOU 3486 CE2 PHE c 46 1956 5618 3781 569 -587 -284 c

ATOM 3487 CZ PHE c 46 10.746 -17. ,782 -32. .930 1. .00 40. .45 c

ANISOU 3487 CZ PHE c 46 4358 7513 3497 590 -1225 -573 c

ATOM 3488 N CYS c 47 17.787 -15. ,599 -33. .641 1. .00 23. .33 N

ANISOU 3488 N CYS c 47 3905 3318 1638 696 42 553 N

ATOM 3489 CA CYS c 47 18.973 -15. ,054 -34. .286 1. .00 23. .55 C

ANISOU 3489 CA CYS c 47 3667 3120 2161 1141 571 257 C

ATOM 3490 C CYS c 47 20.064 -16. ,116 -34. .514 1. .00 23. .55 C

ANISOU 3490 C CYS c 47 3906 3139 1900 1122 1060 369 C

ATOM 3491 O CYS c 47 20.933 -15. ,919 -35. .354 1. .00 26. .28 0

ANISOU 3491 O CYS c 47 3635 4019 2329 1443 1341 130 0

ATOM 3492 CB CYS c 47 19.506 -13. ,838 -33. .515 1. .00 25. .33 c

ANISOU 3492 CB CYS c 47 3707 3155 2761 483 735 474 c

ATOM 3493 SG CYS c 47 18.954 -12. ,225 -34. .155 1. .00 28. .03 s

ANISOU 3493 SG CYS c 47 3967 3558 3121 739 949 741 s

ATOM 3494 N HIS c 48 19.995 -17. ,241 -33. .798 1. .00 24. .97 N

ANISOU 3494 N HIS c 48 4321 2852 2314 1136 218 346 N

ATOM 3495 CA HIS c 48 20.958 -18. ,346 -33. .961 1. .00 25. .74 C

ANISOU 3495 CA HIS c 48 4273 3111 2394 1194 312 134 C

ATOM 3496 C HIS c 48 20.242 -19. ,668 -34. .020 1. .00 26. .54 C ANISOU 3496 C HIS C 48 4120 3232 2730 1295 230 96 C

ATOM 3497 O HIS C 48 20.342 -20. .466 -33. .083 1. .00 26. .68 O

ANISOU 3497 O HIS C 48 3783 3507 2847 952 58 221 O

ATOM 3498 CB HIS C 48 21.930 -18. .403 -32. .792 1. .00 22. .93 C

ANISOU 3498 CB HIS C 48 3106 3268 2337 357 810 229 C

ATOM 3499 CG HIS C 48 22.785 -17. .179 -32. .633 1. .00 26. .70 C

ANISOU 3499 CG HIS C 48 3947 3398 2799 53 68 601 C

ATOM 3500 ND1 HIS C 48 22.320 -16. .036 -32. .093 1. .00 29. .98 N

ANISOU 3500 ND1 HIS C 48 4542 3873 2974 174 520 722 N

ATOM 3501 CD2 HIS C 48 24.124 -16. .960 -32. .930 1. .00 27. .59 C

ANISOU 3501 CD2 HIS C 48 4188 3380 2914 -18 559 1343 C

ATOM 3502 CE1 HIS C 48 23.306 -15. .127 -32. .061 1. .00 27. .69 C

ANISOU 3502 CE1 HIS C 48 4120 4402 1996 8 64 876 C

ATOM 3503 NE2 HIS C 48 24.411 -15. .693 -32. .577 1. .00 28. .59 N

ANISOU 3503 NE2 HIS C 48 3666 4255 2940 -287 -58 451 N

ATOM 3504 N PRO C 49 19.531 -19. .943 -35. .122 1. .00 31. .50 N

ANISOU 3504 N PRO C 49 5044 3778 3143 1161 -477 332 N

ATOM 3505 CA PRO C 49 18.634 -21. .102 -35. .151 1. .00 32. .70 C

ANISOU 3505 CA PRO C 49 4944 4373 3106 889 -210 -74 C

ATOM 3506 C PRO C 49 19.321 -22. .478 -35. .119 1. .00 30. .53 C

ANISOU 3506 C PRO C 49 4823 4191 2585 638 -357 212 C

ATOM 3507 O PRO C 49 18.644 -23. .491 -34. .941 1. .00 37. .18 O

ANISOU 3507 O PRO C 49 7065 3298 3763 506 -874 -424 O

ATOM 3508 CB PRO c 49 17.837 -20. .900 -36. .454 1. .00 38. .03 C

ANISOU 3508 CB PRO c 49 6047 4856 3546 609 -942 -30 C

ATOM 3509 CG PRO c 49 18.088 -19. .482 -36. .867 1. .00 37. .52 C

ANISOU 3509 CG PRO c 49 4939 5166 4149 1209 -941 701 C

ATOM 3510 CD PRO c 49 19.472 -19. .179 -36. .379 1. .00 32. .86 C

ANISOU 3510 CD PRO c 49 5068 4587 2831 1230 -614 307 C

ATOM 3511 N GLU c 50 20.643 -22. .508 -35. .276 1. .00 32. .94 N

ANISOU 3511 N GLU c 50 5156 3950 3409 2167 164 -157 N

ATOM 3512 CA GLU c 50 21.420 -23. .758 -35. .235 1. .00 35. .06 C

ANISOU 3512 CA GLU c 50 6435 3117 3767 1801 336 207 C

ATOM 3513 C GLU c 50 21.739 -24. .212 -33. .805 1. .00 31. .27 C

ANISOU 3513 C GLU c 50 6285 2714 2878 894 1003 -578 C

ATOM 3514 O GLU c 50 22.107 -25. .370 -33. .599 1. .00 28. .72 O

ANISOU 3514 O GLU c 50 5754 2669 2488 314 785 -368 O

ATOM 3515 CB GLU c 50 22.723 -23. .620 -36. .056 1. .00 41. .66 C

ANISOU 3515 CB GLU c 50 7265 3697 4865 2336 1159 155 C

ATOM 3516 CG GLU c 50 23.903 -22. .917 -35. .360 1. .00 43. .76 c

ANISOU 3516 CG GLU c 50 6967 4533 5127 1805 2143 -119 c

ATOM 3517 CD GLU c 50 23.708 -21. .411 -35. .118 1. .00 50. .11 c

ANISOU 3517 CD GLU c 50 7978 4254 6806 1975 670 1073 c

ATOM 3518 OE1 GLU c 50 22.692 -20. .824 -35. .575 1. .00 45. .69 0

ANISOU 3518 OE1 GLU c 50 6865 4846 5646 2687 1743 -266 0

ATOM 3519 OE2 GLU c 50 24.588 -20. .810 -34. .449 1. .00 55. .04 0

ANISOU 3519 OE2 GLU c 50 6977 10220 3712 -335 2602 1345 0

ATOM 3520 N LEU c 51 21.611 -23. .307 -32. .826 1. .00 25. .45 N

ANISOU 3520 N LEU c 51 5169 2522 1977 1330 785 -23 N

ATOM 3521 CA LEU c 51 22.009 -23. .622 -31. .458 1. .00 20. .54 C

ANISOU 3521 CA LEU c 51 3426 2126 2248 700 531 34 C

ATOM 3522 C LEU c 51 21.051 -24. .619 -30. .839 1. .00 21. .12 C

ANISOU 3522 C LEU c 51 3099 2660 2264 551 5 458 C

ATOM 3523 O LEU c 51 19.840 -24. .548 -31. .043 1. .00 23. .20 0

ANISOU 3523 O LEU c 51 3096 3328 2389 647 -263 -214 0

ATOM 3524 CB LEU c 51 22.130 -22. .370 -30. .582 1. .00 18. .71 c

ANISOU 3524 CB LEU c 51 2597 2049 2459 35 403 124 c

ATOM 3525 CG LEU c 51 23.289 -21. .391 -30. .862 1. .00 21. .70 c

ANISOU 3525 CG LEU c 51 2598 2489 3159 -241 269 -156 c

ATOM 3526 CD1 LEU c 51 23.239 -20. .246 -29. .871 1. .00 22. .55 c

ANISOU 3526 CD1 LEU c 51 2794 2221 3551 -94 310 -152 c ATOM 3527 CD2 LEU C 51 24.652 -22..063 -30..808 1..00 26..10 C

ANISOU 3527 CD2 LEU C 51 3041 3502 3371 384 173 58 C

ATOM 3528 N LYS C 52 21.608 -25. .564 -30. .094 1. .00 17. .67 N

ANISOU 3528 N LYS C 52 2505 2272 1936 343 161 335 N

ATOM 3529 CA LYS C 52 20.798 -26. .572 -29. .427 1. .00 17. .31 C

ANISOU 3529 CA LYS C 52 2310 2143 2122 153 99 -5 C

ATOM 3530 C LYS C 52 20.548 -26. .212 -27. .956 1. .00 16. .47 C

ANISOU 3530 C LYS C 52 2388 1685 2182 112 221 -8 C

ATOM 3531 O LYS C 52 21.253 -25. .353 -27. .389 1. .00 16. .39 O

ANISOU 3531 O LYS C 52 2357 2118 1750 196 69 -84 O

ATOM 3532 CB LYS C 52 21.453 -27. .950 -29. .599 1. .00 18. .94 C

ANISOU 3532 CB LYS C 52 3103 1922 2171 12 668 ^■174 C

ATOM 3533 CG LYS C 52 21.571 -28. .328 -31. .081 1. .00 22. .49 C

ANISOU 3533 CG LYS C 52 3090 2916 2539 756 876 ^■839 C

ATOM 3534 CD LYS C 52 22.140 -29. .722 -31. .294 1. .00 24. .06 c

ANISOU 3534 CD LYS C 52 4342 2345 2453 510 540 ^■304 c

ATOM 3535 CE LYS C 52 22.035 -30. .174 -32. .743 1. .00 29. .17 c

ANISOU 3535 CE LYS C 52 5571 2769 2741 1240 555 ^■871 c

ATOM 3536 NZ LYS C 52 23.030 -29. .445 -33. .583 1. .00 33. .32 N

ANISOU 3536 NZ LYS C 52 3523 5608 3527 -144 -1130 ^■391 N

ATOM 3537 N SER c 53 19.533 -26. .843 -27. .358 1. .00 14. .18 N

ANISOU 3537 N SER c 53 1715 1972 1699 605 143 61 N

ATOM 3538 CA SER c 53 19.152 -26. .593 -25. .969 1. .00 13. .26 C

ANISOU 3538 CA SER c 53 1573 1790 1674 -65 253 123 C

ATOM 3539 C SER c 53 20.315 -26. .885 -25. .047 1. .00 13. .61 C

ANISOU 3539 C SER c 53 1929 1887 1353 -13 179 -7 C

ATOM 3540 O SER c 53 21.048 -27. .869 -25. .230 1. .00 16. .62 O

ANISOU 3540 O SER c 53 2323 1971 2018 294 -191 7 O

ATOM 3541 CB SER c 53 17.924 -27. .434 -25. .571 1. .00 13. .05 C

ANISOU 3541 CB SER c 53 1604 1777 1578 -96 214 -40 C

ATOM 3542 OG SER c 53 16.858 -27. .076 -26. .408 1. .00 14. .37 O

ANISOU 3542 OG SER c 53 1895 1617 1948 477 105 -35 O

ATOM 3543 N GLY c 54 20.533 -25. .997 -24. .096 1. .00 13. .11 N

ANISOU 3543 N GLY c 54 1624 1832 1524 -95 -158 -30 N

ATOM 3544 CA GLY c 54 21.662 -26. .182 -23. .188 1. .00 13. .93 C

ANISOU 3544 CA GLY c 54 1813 2021 1459 240 -244 ^■265 C

ATOM 3545 C GLY c 54 22.013 -24. .919 -22. .441 1. .00 14. .73 C

ANISOU 3545 C GLY c 54 1888 1944 1765 25 -434 ^■133 C

ATOM 3546 O GLY c 54 21.218 -23. .976 -22. .363 1. .00 15. .51 O

ANISOU 3546 O GLY c 54 1991 2042 1859 86 -58 107 O

ATOM 3547 N GLU c 55 23.219 -24. .916 -21. .892 1. .00 13. .46 N

ANISOU 3547 N GLU c 55 1596 2016 1499 -233 -46 ^■221 N

ATOM 3548 CA GLU c 55 23.691 -23. .832 -21. .068 1. .00 12. .10 C

ANISOU 3548 CA GLU c 55 1222 1696 1677 -280 -105 15 C

ATOM 3549 C GLU c 55 24.176 -22. .667 -21. .899 1. .00 13. .07 C

ANISOU 3549 C GLU c 55 1576 1659 1729 -65 1 128 C

ATOM 3550 O GLU c 55 25.023 -22. .839 -22. .810 1. .00 14. .59 O

ANISOU 3550 O GLU c 55 1218 1894 2430 221 226 87 O

ATOM 3551 CB GLU c 55 24.821 -24. .327 -20. .185 1. .00 14. .61 C

ANISOU 3551 CB GLU c 55 1775 1765 2010 -43 -499 31 C

ATOM 3552 CG GLU c 55 25.439 -23. .243 -19. .305 1. .00 18. .91 c

ANISOU 3552 CG GLU c 55 2211 2253 2720 -256 -964 ^■177 c

ATOM 3553 CD GLU c 55 26.284 -23. .829 -18. .196 1. .00 22. .38 c

ANISOU 3553 CD GLU c 55 1531 3285 3684 709 -776 195 c

ATOM 3554 OE1 GLU c 55 25.719 -24. .198 -17. .139 1. .00 27. .40 0

ANISOU 3554 OE1 GLU c 55 2584 4106 3719 137 -953 482 0

ATOM 3555 OE2 GLU c 55 27.514 -23. .934 -18. .388 1. .00 25. .03 0

ANISOU 3555 OE2 GLU c 55 1475 4178 3857 854 -817 ^■233 0

ATOM 3556 N TYR c 56 23.657 -21. .493 -21. .563 1. .00 12. .59 N

ANISOU 3556 N TYR c 56 1326 1622 1833 -150 -59 32 N

ATOM 3557 CA TYR c 56 24.050 -20. .222 -22. .194 1. .00 12. .43 C ANISOU 3557 CA TYR C 56 1480 1482 1758 123 -273 127 C

ATOM 3558 C TYR c 56 24.067 -19. ,091 -21. .164 1. .00 14. .29 C

ANISOU 3558 C TYR c 56 1845 1874 1711 -83 - 231 -83 C

ATOM 3559 O TYR c 56 23.542 -19. ,228 -20. .044 1. .00 13. .53 O

ANISOU 3559 O TYR c 56 947 2031 2162 148 -57 299 O

ATOM 3560 CB TYR c 56 23.098 -19. ,839 -23. .354 1. .00 12. .38 C

ANISOU 3560 CB TYR c 56 1577 1343 1780 6 - 403 74 C

ATOM 3561 CG TYR c 56 23.125 -20. ,840 -24. .476 1. .00 13. .22 C

ANISOU 3561 CG TYR c 56 1609 1457 1955 413 101 -28 C

ATOM 3562 CD1 TYR c 56 24.079 -20. ,751 -25. .504 1. .00 14. .68 C

ANISOU 3562 CD1 TYR c 56 1753 1822 2001 417 133 146 C

ATOM 3563 CD2 TYR c 56 22.221 -21. ,909 -24. .494 1. .00 14. .02 C

ANISOU 3563 CD2 TYR c 56 1803 1805 1716 127 - 155 -107 C

ATOM 3564 CE1 TYR c 56 24.116 -21. ,698 -26. .519 1. .00 14. .99 C

ANISOU 3564 CE1 TYR c 56 1867 2099 1726 167 459 165 c

ATOM 3565 CE2 TYR c 56 22.261 -22. ,862 -25. .499 1. .00 15. .15 c

ANISOU 3565 CE2 TYR c 56 1906 1831 2019 162 361 -238 c

ATOM 3566 CZ TYR c 56 23.208 -22. ,749 -26. .506 1. .00 16. .29 c

ANISOU 3566 CZ TYR c 56 2162 2179 1848 6 369 5 c

ATOM 3567 OH TYR c 56 23.221 -23. ,700 -27. .496 1. .00 17. .35 0

ANISOU 3567 OH TYR c 56 2495 2055 2039 -41 631 54 0

ATOM 3568 N TRP c 57 24.642 -17. ,960 -21. .566 1. .00 13. .48 N

ANISOU 3568 N TRP c 57 1110 1789 2223 195 - 304 -109 N

ATOM 3569 CA TRP c 57 24.646 -16. ,767 -20. .734 1. .00 13. .01 C

ANISOU 3569 CA TRP c 57 1372 1565 2007 154 - 145 58 C

ATOM 3570 C TRP c 57 23.773 -15. ,746 -21. .374 1. .00 13. .65 c

ANISOU 3570 C TRP c 57 1562 1883 1740 319 - 262 -47 c

ATOM 3571 O TRP c 57 23.894 -15. ,486 -22. .580 1. .00 14. .88 0

ANISOU 3571 O TRP c 57 1503 2253 1895 159 -69 171 0

ATOM 3572 CB TRP c 57 26.069 -16. ,231 -20. .573 1. .00 13. .67 c

ANISOU 3572 CB TRP c 57 1381 1931 1879 154 - 283 515 c

ATOM 3573 CG TRP c 57 26.940 -17. ,134 -19. .732 1. .00 14. .35 c

ANISOU 3573 CG TRP c 57 1173 2072 2204 577 -12 448 c

ATOM 3574 CD1 TRP c 57 27.550 -18. ,340 -20. .109 1. .00 16. .67 c

ANISOU 3574 CD1 TRP c 57 1702 1853 2776 532 -69 473 c

ATOM 3575 CD2 TRP c 57 27.314 -16. ,941 -18. .326 1. .00 14. .12 c

ANISOU 3575 CD2 TRP c 57 1077 2021 2267 145 61 468 c

ATOM 3576 NE1 TRP c 57 28.259 -18. ,877 -19. .057 1. .00 18. .19 N

ANISOU 3576 NE1 TRP c 57 1757 2675 2479 622 - 101 230 N

ATOM 3577 CE2 TRP c 57 28.163 -18. ,084 -17. .963 1. .00 17. .05 C

ANISOU 3577 CE2 TRP c 57 1687 2220 2571 505 75 450 C

ATOM 3578 CE3 TRP c 57 27.057 -15. ,955 -17. .369 1. .00 17. .46 c

ANISOU 3578 CE3 TRP c 57 1616 2369 2648 270 -8 171 c

ATOM 3579 CZ2 TRP c 57 28.712 -18. ,218 -16. .690 1. .00 19. .00 c

ANISOU 3579 CZ2 TRP c 57 1579 2805 2833 604 - 101 636 c

ATOM 3580 CZ3 TRP c 57 27.613 -16. ,105 -16. .089 1. .00 19. .27 c

ANISOU 3580 CZ3 TRP c 57 1994 2389 2936 367 - 171 803 c

ATOM 3581 CH2 TRP c 57 28.429 -17. ,206 -15. .765 1. .00 21. .12 c

ANISOU 3581 CH2 TRP c 57 2271 2607 3147 659 - 291 612 c

ATOM 3582 N VAL c 58 22.874 -15. ,162 -20. .581 1. .00 12. .58 N

ANISOU 3582 N VAL c 58 1388 1488 1904 203 - 186 -79 N

ATOM 3583 CA VAL c 58 21.996 -14. ,103 -21. .076 1. .00 13. .12 C

ANISOU 3583 CA VAL c 58 1779 1262 1942 104 - 351 -92 C

ATOM 3584 C VAL c 58 22.116 -12. ,876 -20. .190 1. .00 12. .54 C

ANISOU 3584 C VAL c 58 1731 1214 1819 -3 -30 -24 C

ATOM 3585 O VAL c 58 22.554 -12. ,986 -19. .036 1. .00 12. .70 0

ANISOU 3585 O VAL c 58 1574 1320 1930 61 48 302 0

ATOM 3586 CB VAL c 58 20.526 -14. ,563 -21. .217 1. .00 13. .40 c

ANISOU 3586 CB VAL c 58 1723 1565 1801 -27 - 157 -256 c

ATOM 3587 CGI VAL c 58 20.439 -15. ,710 -22. .237 1. .00 15. .38 c

ANISOU 3587 CGI VAL c 58 2135 1893 1813 32 -72 -441 c ATOM 3588 CG2 VAL C 58 19.934 -14..959 -19..860 1..00 13..44 C

ANISOU 3588 CG2 VAL C 58 1576 1721 1809 -129 - 307 ^■127 C

ATOM 3589 N ASP C 59 21.772 -11. .710 -20. .735 1. .00 11. .63 N

ANISOU 3589 N ASP C 59 1385 1186 1847 -70 Ill 62 N

ATOM 3590 CA ASP C 59 21.995 -10. .464 -20. .033 1. .00 11. .65 C

ANISOU 3590 CA ASP C 59 1255 1332 1838 -227 87 53 C

ATOM 3591 C ASP C 59 20.789 -9. .556 -20. .262 1. .00 13. .30 C

ANISOU 3591 C ASP C 59 1528 1582 1941 -9 25 104 C

ATOM 3592 O ASP C 59 20.848 -8. .633 -21. .090 1. .00 12. .67 O

ANISOU 3592 O ASP C 59 1236 1691 1884 1 -34 189 O

ATOM 3593 CB ASP C 59 23.298 -9. .806 -20. .517 1. .00 12. .45 C

ANISOU 3593 CB ASP C 59 1224 1342 2163 -88 315 42 C

ATOM 3594 CG ASP C 59 23.718 -8. .666 -19. .636 1. .00 13. .82 C

ANISOU 3594 CG ASP C 59 1383 1933 1934 -155 -83 -54 C

ATOM 3595 OD1 ASP C 59 23.353 -8. .686 -18. .440 1. .00 15. .48 0

ANISOU 3595 OD1 ASP C 59 1180 2344 2358 -245 363 -65 0

ATOM 3596 OD2 ASP C 59 24.387 -7. .725 -20. .123 1. .00 15. .25 0

ANISOU 3596 OD2 ASP C 59 1319 1701 2773 -25 -58 37 0

ATOM 3597 N PRO C 60 19.677 -9. .831 -19. .547 1. .00 12. .71 N

ANISOU 3597 N PRO C 60 1540 1610 1679 43 -53 194 N

ATOM 3598 CA PRO C 60 18.444 -9. .107 -19. .839 1. .00 12. .91 C

ANISOU 3598 CA PRO C 60 1540 1668 1694 55 - 141 96 C

ATOM 3599 C PRO C 60 18.548 -7. .591 -19. .692 1. .00 11. .88 C

ANISOU 3599 C PRO C 60 1534 1653 1325 136 -96 58 C

ATOM 3600 O PRO c 60 17.942 -6. .870 -20. .486 1. .00 12. .93 O

ANISOU 3600 O PRO c 60 1948 1221 1743 72 - 118 255 0

ATOM 3601 CB PRO c 60 17.446 -9. .703 -18. .836 1. .00 13. .35 c

ANISOU 3601 CB PRO c 60 1718 1668 1683 -178 - 237 121 c

ATOM 3602 CG PRO c 60 17.943 -11. .097 -18. .636 1. .00 13. .36 c

ANISOU 3602 CG PRO c 60 1233 1950 1890 33 - 485 336 c

ATOM 3603 CD PRO c 60 19.446 -10. .923 -18. .580 1. .00 12. .76 c

ANISOU 3603 CD PRO c 60 1234 1702 1913 -119 209 197 c

ATOM 3604 N ASN c 61 19.334 -7. .094 -18. .734 1. .00 12. .95 N

ANISOU 3604 N ASN c 61 1516 1723 1678 -33 -83 -53 N

ATOM 3605 CA ASN c 61 19.426 -5. .643 -18. .563 1. .00 12. .49 C

ANISOU 3605 CA ASN c 61 1496 1731 1517 -2 - 156 51 C

ATOM 3606 C ASN c 61 20.394 -4. .968 -19. .556 1. .00 12. .86 C

ANISOU 3606 C ASN c 61 1636 1757 1491 -31 - 129 39 C

ATOM 3607 O ASN c 61 20.516 -3. .748 -19. .554 1. .00 14. .30 0

ANISOU 3607 O ASN c 61 1860 1789 1784 228 - 165 26 0

ATOM 3608 CB ASN c 61 19.752 -5. .268 -17. .107 1. .00 13. .37 c

ANISOU 3608 CB ASN c 61 1670 1909 1500 225 21 -96 c

ATOM 3609 CG ASN c 61 21.083 -5. .842 -16. .621 1. .00 13. .69 c

ANISOU 3609 CG ASN c 61 1429 2355 1416 112 15 -88 c

ATOM 3610 OD1 ASN c 61 21.895 -6. .359 -17. .405 1. .00 13. .89 0

ANISOU 3610 OD1 ASN c 61 1999 1814 1465 269 48 -65 0

ATOM 3611 ND2 ASN c 61 21.324 -5. .736 -15. .317 1. .00 11. .56 N

ANISOU 3611 ND2 ASN c 61 853 2262 1278 422 240 309 N

ATOM 3612 N AGLN c 62 21.072 -5. .783 -20. .372 0. .50 12. .30 N

ANISOU 3612 N AGLN c 62 1791 1749 1133 9 - 441 -64 N

ATOM 3613 CA AGLN c 62 22.098 -5. .320 -21. .320 0. .50 13. .31 C

ANISOU 3613 CA AGLN c 62 1926 1668 1460 -119 - 407 149 C

ATOM 3614 C AGLN c 62 23.141 -4. .442 -20. .605 0. .50 13. .33 C

ANISOU 3614 C AGLN c 62 1928 1596 1540 -299 - 133 118 C

ATOM 3615 O AGLN c 62 23.568 -4. .798 -19. .501 0. .50 13. .69 O

ANISOU 3615 O AGLN c 62 1872 1845 1485 -388 -61 130 O

ATOM 3616 CB AGLN c 62 21.452 -4. .634 -22. .533 0. .50 14. .70 C

ANISOU 3616 CB AGLN c 62 2080 1928 1576 5 - 459 252 C

ATOM 3617 CG AGLN c 62 20.411 -5. .508 -23. .231 0. .50 16. .77 C

ANISOU 3617 CG AGLN c 62 2187 2463 1720 -201 - 802 534 C

ATOM 3618 CD AGLN c 62 21.021 -6. .654 -24. .021 0. .50 18. .47 c ANISOU 3618 CD AGLN C 62 2406 2676 1935 -165 -718 439 C

ATOM 3619 OE1AGLN C 62 21.483 -7. ,652 -23. .453 0. .50 18. .49 O

ANISOU 3619 OE1AGLN C 62 2196 2682 2145 -842 -656 982 O

ATOM 3620 NE2AGLN C 62 21.014 -6. ,523 -25. .345 0. .50 18. .47 N

ANISOU 3620 NE2AGLN C 62 1952 3026 2041 -552 -1508 1249 N

ATOM 3621 N BGLN C 62 21.054 -5. ,761 -20. .404 0. .50 12. .44 N

ANISOU 3621 N BGLN C 62 1788 1753 1186 -56 -394 -107 N

ATOM 3622 CA BGLN C 62 22.040 -5. ,242 -21. .364 0. .50 13. .59 C

ANISOU 3622 CA BGLN C 62 1948 1670 1543 -187 -297 3 C

ATOM 3623 C BGLN C 62 23.113 -4. ,436 -20. .620 0. .50 13. .28 C

ANISOU 3623 C BGLN C 62 1908 1571 1564 -339 -95 61 C

ATOM 3624 O BGLN C 62 23.527 -4. ,829 -19. .524 0. .50 13. .74 O

ANISOU 3624 O BGLN C 62 1891 1815 1513 -390 -57 42 O

ATOM 3625 CB BGLN C 62 21.361 -4. ,396 -22. .458 0. .50 13. .93 C

ANISOU 3625 CB BGLN C 62 1964 1726 1602 -53 -236 35 C

ATOM 3626 CG BGLN C 62 20.253 -5. ,118 -23. .213 0. .50 16. .97 C

ANISOU 3626 CG BGLN c 62 2038 2474 1935 -238 -374 -43 C

ATOM 3627 CD BGLN c 62 19.680 -4. ,289 -24. .349 0. .50 18. .03 C

ANISOU 3627 CD BGLN c 62 2075 2426 2347 -249 -315 286 C

ATOM 3628 OE1BGLN c 62 19.086 -3. ,227 -24. .126 0. .50 18. .46 O

ANISOU 3628 OE1BGLN c 62 1581 3305 2127 69 -186 -170 O

ATOM 3629 NE2BGLN c 62 19.851 -4. ,774 -25. .580 0. .50 19. .65 N

ANISOU 3629 NE2BGLN c 62 1768 2451 3245 -317 204 -577 N

ATOM 3630 N GLY c 63 23.552 -3. ,321 -21. .205 1. .00 14. .66 N

ANISOU 3630 N GLY c 63 2161 1402 2006 -373 157 -39 N

ATOM 3631 CA GLY c 63 24.562 -2. ,447 -20. .568 1. .00 14. .67 C

ANISOU 3631 CA GLY c 63 1881 1882 1809 -67 -2 -247 C

ATOM 3632 C GLY c 63 25.833 -3. ,225 -20. .229 1. .00 16. .27 C

ANISOU 3632 C GLY c 63 1935 2199 2048 70 137 53 C

ATOM 3633 O GLY c 63 26.350 -3. ,943 -21. .078 1. .00 18. .16 O

ANISOU 3633 O GLY c 63 2191 2165 2542 -27 388 -231 O

ATOM 3634 N CYS c 64 26.303 -3. ,117 -18. .982 1. .00 14. .90 N

ANISOU 3634 N CYS c 64 1623 1964 2073 -178 341 192 N

ATOM 3635 CA CYS c 64 27.472 -3. ,885 -18. .509 1. .00 15. .20 C

ANISOU 3635 CA CYS c 64 1538 2442 1795 -328 40 258 C

ATOM 3636 C CYS c 64 27.272 -5. ,395 -18. .695 1. .00 16. .81 C

ANISOU 3636 C CYS c 64 1457 2526 2402 -129 82 -157 C

ATOM 3637 O CYS c 64 26.288 -5. ,970 -18. .217 1. .00 16. .20 O

ANISOU 3637 O CYS c 64 1687 1996 2472 -150 70 -10 O

ATOM 3638 CB CYS c 64 27.765 -3. ,556 -17. .039 1. .00 18. .97 C

ANISOU 3638 CB CYS c 64 2374 2828 2005 146 -94 -243 C

ATOM 3639 SG CYS c 64 29.150 -4. ,448 -16. .280 1. .00 20. .65 s

ANISOU 3639 SG CYS c 64 2267 2484 3095 74 -163 -310 s

ATOM 3640 N LYS c 65 28.195 -6. ,045 -19. .388 1. .00 17. .36 N

ANISOU 3640 N LYS c 65 1594 2601 2401 -301 179 -465 N

ATOM 3641 CA LYS c 65 28.039 -7. ,456 -19. .716 1. .00 17. .55 C

ANISOU 3641 CA LYS c 65 2044 2507 2117 -306 39 -268 C

ATOM 3642 C LYS c 65 28.391 -8. ,385 -18. .558 1. .00 16. .05 C

ANISOU 3642 C LYS c 65 1347 2300 2450 -78 -3 -332 C

ATOM 3643 O LYS c 65 28.051 -9. ,568 -18. .580 1. .00 16. .53 O

ANISOU 3643 O LYS c 65 1446 2406 2426 -199 329 -100 O

ATOM 3644 CB LYS c 65 28.917 -7. ,805 -20. .906 1. .00 19. .76 C

ANISOU 3644 CB LYS c 65 2056 3063 2388 -582 379 -195 c

ATOM 3645 CG LYS c 65 28.399 -7. ,283 -22. .232 1. .00 21. .61 c

ANISOU 3645 CG LYS c 65 2767 2698 2745 -459 -94 -161 c

ATOM 3646 CD LYS c 65 29.465 -7. ,452 -23. .308 1. .00 26. .50 c

ANISOU 3646 CD LYS c 65 3832 3714 2522 -486 385 -153 c

ATOM 3647 CE LYS c 65 28.934 -7. ,121 -24. .694 1. .00 28. .92 c

ANISOU 3647 CE LYS c 65 4000 3478 3508 241 -263 735 c

ATOM 3648 NZ LYS c 65 28.396 -5. ,735 -24. .791 1. .00 37. .80 N

ANISOU 3648 NZ LYS c 65 6073 3456 4830 389 584 267 N ATOM 3649 N LEU C 66 29.086 -7.,846 -17..563 1..00 15..86 N

ANISOU 3649 N LEU C 66 1545 2426 2052 -5 231 ^■510 N

ATOM 3650 CA LEU C 66 29.650 -8. ,649 -16. .482 1. .00 16. .89 C

ANISOU 3650 CA LEU C 66 1241 2739 2437 -140 - 342 ^■599 C

ATOM 3651 C LEU C 66 28.642 -9. ,210 -15. .476 1. .00 17. .60 C

ANISOU 3651 C LEU C 66 1607 2574 2505 7 - 397 51 C

ATOM 3652 O LEU C 66 28.988 -10. ,098 -14. .701 1. .00 16. .16 O

ANISOU 3652 O LEU C 66 1267 2396 2475 594 - 369 ^■334 O

ATOM 3653 CB LEU C 66 30.754 -7. ,867 -15. .750 1. .00 17. .69 C

ANISOU 3653 CB LEU C 66 1108 2581 3033 139 - 674 ^■737 C

ATOM 3654 CG LEU C 66 31.950 -7. ,417 -16. .609 1. .00 23. .23 C

ANISOU 3654 CG LEU C 66 2038 3407 3380 -171 -57 ^■761 C

ATOM 3655 CD1 LEU C 66 32.961 -6. ,614 -15. .799 1. .00 24. .85 C

ANISOU 3655 CD1 LEU C 66 1292 3843 4304 298 - 941 ^■343 C

ATOM 3656 CD2 LEU C 66 32.630 -8. ,597 -17. .291 1. .00 28. .57 C

ANISOU 3656 CD2 LEU C 66 2568 3688 4598 156 312 ^■862 C

ATOM 3657 N ASP C 67 27.409 -8. ,697 -15. .479 1. .00 14. .04 N

ANISOU 3657 N ASP C 67 1505 1956 1872 -178 16 ^■172 N

ATOM 3658 CA ASP C 67 26.388 -9. ,226 -14. .568 1. .00 13. .55 C

ANISOU 3658 CA ASP C 67 1484 1867 1796 59 40 ^■132 C

ATOM 3659 C ASP c 67 25.437 -10. ,192 -15. .278 1. .00 12. .91 C

ANISOU 3659 C ASP c 67 1605 1711 1588 193 - 170 81 C

ATOM 3660 O ASP c 67 24.314 -10. ,465 -14. .790 1. .00 13. .29 O

ANISOU 3660 O ASP c 67 1609 1546 1894 314 -93 133 O

ATOM 3661 CB ASP c 67 25.634 -8. ,086 -13. .874 1. .00 14. .90 C

ANISOU 3661 CB ASP c 67 1908 1609 2143 227 - 107 -27 C

ATOM 3662 CG ASP c 67 24.836 -7. ,214 -14. .852 1. .00 14. .15 c

ANISOU 3662 CG ASP c 67 1358 1667 2349 -194 - 273 50 c

ATOM 3663 OD1 ASP c 67 24.905 -7. ,463 -16. .081 1. .00 14. .33 0

ANISOU 3663 OD1 ASP c 67 1197 1996 2251 108 - 155 283 0

ATOM 3664 OD2 ASP c 67 24.146 -6. ,281 -14. .387 1. .00 15. .57 0

ANISOU 3664 OD2 ASP c 67 1639 2047 2230 -76 -51 ^■180 0

ATOM 3665 N ALA c 68 25.906 -10. ,752 -16. .398 1. .00 13. .02 N

ANISOU 3665 N ALA c 68 1418 1857 1671 215 -79 2 N

ATOM 3666 CA ALA c 68 25.146 -11. ,764 -17. .143 1. .00 13. .41 C

ANISOU 3666 CA ALA c 68 1494 1725 1877 40 167 -17 C

ATOM 3667 C ALA c 68 24.872 -12. ,971 -16. .245 1. .00 13. .50 C

ANISOU 3667 C ALA c 68 1470 1685 1975 -17 10 13 C

ATOM 3668 O ALA c 68 25.623 -13. ,258 -15. .306 1. .00 13. .98 O

ANISOU 3668 O ALA c 68 1346 1954 2012 36 47 21 0

ATOM 3669 CB ALA c 68 25.891 -12. ,198 -18. .409 1. .00 12. .36 c

ANISOU 3669 CB ALA c 68 1638 1471 1587 -176 65 75 c

ATOM 3670 N ILE c 69 23.784 -13. ,664 -16. .536 1. .00 13. .45 N

ANISOU 3670 N ILE c 69 1354 1743 2012 -26 94 31 N

ATOM 3671 CA ILE c 69 23.378 -14. ,848 -15. .784 1. .00 13. .07 C

ANISOU 3671 CA ILE c 69 1331 1614 2019 -48 44 12 C

ATOM 3672 C ILE c 69 23.438 -16. ,125 -16. .639 1. .00 12. .69 C

ANISOU 3672 C ILE c 69 1237 1468 2114 313 150 132 C

ATOM 3673 O ILE c 69 23.151 -16. ,119 -17. .845 1. .00 14. .33 O

ANISOU 3673 O ILE c 69 1664 1495 2285 158 -50 225 O

ATOM 3674 CB ILE c 69 21.960 -14. ,680 -15. .125 1. .00 15. .55 c

ANISOU 3674 CB ILE c 69 1554 2188 2167 470 183 ^■463 c

ATOM 3675 CGI ILE c 69 20.880 -14. ,309 -16. .162 1. .00 17. .02 c

ANISOU 3675 CGI ILE c 69 1787 2046 2631 484 72 -54 c

ATOM 3676 CG2 ILE c 69 21.997 -13. ,651 -13. .989 1. .00 15. .50 c

ANISOU 3676 CG2 ILE c 69 1616 2394 1880 -134 791 ^■355 c

ATOM 3677 CD1 ILE c 69 19.438 -14. ,396 -15. .657 1. .00 19. .85 c

ANISOU 3677 CD1 ILE c 69 1877 2785 2880 -48 71 ^■208 c

ATOM 3678 N LYS c 70 23.805 -17. ,223 -15. .986 1. .00 12. .63 N

ANISOU 3678 N LYS c 70 1099 1268 2431 -19 - 310 72 N

ATOM 3679 CA LYS c 70 23.914 -18. ,530 -16. .619 1. .00 13. .22 C ANISOU 3679 CA LYS c 70 1185 1422 2415 359 -73 11 C

ATOM 3680 C LYS c 70 22.570 -19. .224 -16. .551 1. .00 13. .91 C

ANISOU 3680 C LYS c 70 1196 2131 1956 195 -351 154 C

ATOM 3681 O LYS c 70 21.984 -19. .330 -15. .469 1. .00 15. .38 O

ANISOU 3681 O LYS c 70 1597 2344 1900 -142 -246 165 O

ATOM 3682 CB LYS c 70 24.946 -19. .357 -15. .865 1. .00 16. .80 C

ANISOU 3682 CB LYS c 70 1695 1668 3017 687 -474 -46 C

ATOM 3683 CG LYS c 70 25.348 -20. .637 -16. .571 1. .00 19. .62 C

ANISOU 3683 CG LYS c 70 2296 2019 3139 1345 -363 51 C

ATOM 3684 CD LYS c 70 26.561 -21. .246 -15. .879 1. .00 27. .75 C

ANISOU 3684 CD LYS c 70 2349 3628 4566 1794 -850 299 C

ATOM 3685 CE LYS c 70 26.214 -21. .768 -14. .495 1. .00 32. .50 C

ANISOU 3685 CE LYS c 70 3336 4363 4647 1836 -1925 555 C

ATOM 3686 NZ LYS c 70 27.415 -22. .348 -13. .840 1. .00 31. .94 N

ANISOU 3686 NZ LYS c 70 4263 3842 4030 2600 -1994 1007 N

ATOM 3687 N VAL c 71 22.084 -19. .693 -17. .699 1. .00 13. .79 N

ANISOU 3687 N VAL c 71 1424 1795 2018 -22 -87 -59 N

ATOM 3688 CA VAL c 71 20.730 -20. .224 -17. .797 1. .00 11. .61 C

ANISOU 3688 CA VAL c 71 1432 1438 1538 73 -317 220 C

ATOM 3689 C VAL c 71 20.717 -21. .493 -18. .649 1. .00 11. .56 C

ANISOU 3689 C VAL c 71 1366 1582 1443 -50 -177 155 C

ATOM 3690 O VAL c 71 21.704 -21. .826 -19. .309 1. .00 13. .08 O

ANISOU 3690 O VAL c 71 1220 1792 1955 -340 55 146 O

ATOM 3691 CB VAL c 71 19.737 -19. .175 -18. .379 1. .00 11. .06 C

ANISOU 3691 CB VAL c 71 1156 1608 1436 141 -240 58 C

ATOM 3692 CGI VAL c 71 19.750 -17. .896 -17. .547 1. .00 12. .46 C

ANISOU 3692 CGI VAL c 71 1453 1385 1894 232 -194 67 C

ATOM 3693 CG2 VAL c 71 20.032 -18. .865 -19. .847 1. .00 12. .39 C

ANISOU 3693 CG2 VAL c 71 1288 1808 1610 -15 -12 276 C

ATOM 3694 N PHE c 72 19.592 -22. .188 -18. .640 1. .00 12. .49 N

ANISOU 3694 N PHE c 72 1516 1537 1692 -181 -199 86 N

ATOM 3695 CA PHE c 72 19.327 -23. .210 -19. .637 1. .00 12. .93 C

ANISOU 3695 CA PHE c 72 2123 1381 1406 -232 -129 288 C

ATOM 3696 C PHE c 72 18.344 -22. .623 -20. .645 1. .00 13. .72 C

ANISOU 3696 C PHE c 72 1789 1716 1707 -108 -193 165 C

ATOM 3697 O PHE c 72 17.284 -22. .121 -20. .252 1. .00 14. .30 O

ANISOU 3697 O PHE c 72 2001 1831 1601 163 -340 115 O

ATOM 3698 CB PHE c 72 18.734 -24. .461 -18. .997 1. .00 12. .03 C

ANISOU 3698 CB PHE c 72 1612 1345 1613 -230 -121 200 C

ATOM 3699 CG PHE c 72 18.322 -25. .515 -19. .993 1. .00 14. .93 c

ANISOU 3699 CG PHE c 72 2066 1340 2267 -358 -223 -27 c

ATOM 3700 CD1 PHE c 72 19.238 -26. .468 -20. .450 1. .00 15. .44 c

ANISOU 3700 CD1 PHE c 72 2290 1727 1848 -199 99 -20 c

ATOM 3701 CD2 PHE c 72 16.994 -25. .582 -20. .454 1. .00 13. .41 c

ANISOU 3701 CD2 PHE c 72 2000 1029 2066 -353 -257 185 c

ATOM 3702 CE1 PHE c 72 18.844 -27. .464 -21. .353 1. .00 14. .63 c

ANISOU 3702 CE1 PHE c 72 2105 1436 2018 -43 -59 77 c

ATOM 3703 CE2 PHE c 72 16.612 -26. .564 -21. .365 1. .00 13. .18 c

ANISOU 3703 CE2 PHE c 72 2153 883 1968 -176 98 119 c

ATOM 3704 CZ PHE c 72 17.530 -27. .515 -21. .801 1. .00 15. .09 c

ANISOU 3704 CZ PHE c 72 2007 1574 2152 17 113 -101 c

ATOM 3705 N CYS c 73 18.710 -22. .680 -21. .927 1. .00 12. .83 N

ANISOU 3705 N CYS c 73 1884 1374 1616 62 -189 324 N

ATOM 3706 CA CYS c 73 17.825 -22. .271 -23. .021 1. .00 12. .88 C

ANISOU 3706 CA CYS c 73 1821 1644 1428 -95 -219 86 C

ATOM 3707 C CYS c 73 17.169 -23. .486 -23. .607 1. .00 12. .60 c

ANISOU 3707 C CYS c 73 1634 1520 1632 -109 186 73 c

ATOM 3708 O CYS c 73 17.849 -24. .424 -24. .029 1. .00 12. .47 0

ANISOU 3708 O CYS c 73 1522 1738 1477 -41 -17 -265 0

ATOM 3709 CB CYS c 73 18.600 -21. .566 -24. .143 1. .00 13. .67 c

ANISOU 3709 CB CYS c 73 1870 1846 1476 138 144 -68 c ATOM 3710 SG CYS C 73 19.282 -19..956 -23..703 1..00 14..24 S

ANISOU 3710 SG CYS C 73 1573 2122 1715 114 -4 -58 S

ATOM 3711 N ASN C 74 15.844 -23. .494 -23. .613 1. .00 12. .18 N

ANISOU 3711 N ASN C 74 1548 1370 1707 -73 -108 -61 N

ATOM 3712 CA ASN C 74 15.129 -24. .523 -24. .355 1. .00 12. .47 C

ANISOU 3712 CA ASN C 74 1633 1599 1504 -187 72 -202 C

ATOM 3713 C ASN C 74 14.982 -23. .966 -25. .739 1. .00 13. .20 C

ANISOU 3713 C ASN C 74 1475 1810 1729 -53 3 -13 C

ATOM 3714 O ASN C 74 14.205 -23. .052 -25. .936 1. .00 15. .03 O

ANISOU 3714 O ASN C 74 1807 2023 1879 162 -77 130 O

ATOM 3715 CB ASN C 74 13.759 -24. .820 -23. .731 1. .00 13. .28 C

ANISOU 3715 CB ASN C 74 1387 1646 2009 -290 -121 -285 C

ATOM 3716 CG ASN C 74 13.044 -25. .958 -24. .436 1. .00 14. .12 c

ANISOU 3716 CG ASN C 74 1559 1867 1937 -523 -171 -197 c

ATOM 3717 OD1 ASN C 74 13.131 -26. .088 -25. .663 1. .00 15. .18 0

ANISOU 3717 OD1 ASN C 74 1795 2084 1886 -220 -397 131 0

ATOM 3718 ND2 ASN C 74 12.327 -26. .790 -23. .670 1. .00 15. .65 N

ANISOU 3718 ND2 ASN C 74 1864 2320 1763 -463 320 -265 N

ATOM 3719 N MET C 75 15.761 -24. .488 -26. .689 1. .00 13. .53 N

ANISOU 3719 N MET C 75 1910 1677 1553 163 -154 -217 N

ATOM 3720 CA MET C 75 15.760 -23. .941 -28. .053 1. .00 15. .01 C

ANISOU 3720 CA MET C 75 1486 2661 1553 271 127 -145 C

ATOM 3721 C MET C 75 14.565 -24. .374 -28. .897 1. .00 15. .32 C

ANISOU 3721 C MET C 75 1821 2218 1779 -55 18 -231 C

ATOM 3722 O MET c 75 14.371 -23. .871 -30. .009 1. .00 18. .72 O

ANISOU 3722 O MET c 75 2588 2574 1948 114 -51 36 O

ATOM 3723 CB MET c 75 17.075 -24. .213 -28. .781 1. .00 13. .96 C

ANISOU 3723 CB MET c 75 1354 2004 1946 150 213 19 C

ATOM 3724 CG MET c 75 18.241 -23. .469 -28. .194 1. .00 16. .60 C

ANISOU 3724 CG MET c 75 1450 2635 2218 189 32 -512 C

ATOM 3725 SD MET c 75 17.957 -21. .712 -27. .920 1. .00 19. .00 S

ANISOU 3725 SD MET c 75 1980 2578 2661 343 -94 220 s

ATOM 3726 CE MET c 75 19.651 -21. .229 -27. .624 1. .00 19. .49 c

ANISOU 3726 CE MET c 75 2085 2609 2711 -77 286 -277 c

ATOM 3727 N GLU c 76 13.750 -25. .282 -28. .364 1. .00 16. .47 N

ANISOU 3727 N GLU c 76 1713 2434 2110 -125 -34 -67 N

ATOM 3728 CA GLU c 76 12.515 -25. .638 -29. .061 1. .00 17. .12 C

ANISOU 3728 CA GLU c 76 1755 2744 2006 -142 -40 -244 C

ATOM 3729 C GLU c 76 11.456 -24. .593 -28. .753 1. .00 17. .57 C

ANISOU 3729 C GLU c 76 2087 2571 2016 89 -328 -130 C

ATOM 3730 O GLU c 76 10.731 -24. .122 -29. .658 1. .00 20. .44 O

ANISOU 3730 O GLU c 76 1833 3332 2602 419 -633 -297 0

ATOM 3731 CB GLU c 76 12.033 -27. .021 -28. .650 1. .00 20. .66 c

ANISOU 3731 CB GLU c 76 2970 2376 2502 117 -305 -66 c

ATOM 3732 CG GLU c 76 12.990 -28. .151 -29. .026 1. .00 31. .83 c

ANISOU 3732 CG GLU c 76 3652 4134 4305 927 -184 -953 c

ATOM 3733 CD GLU c 76 13.047 -28. .438 -30. .519 1. .00 42. .70 c

ANISOU 3733 CD GLU c 76 5745 6083 4393 756 -1107 - 1282 c

ATOM 3734 OE1 GLU c 76 12.109 -28. .034 -31. .253 1. .00 41. .53 0

ANISOU 3734 OE1 GLU c 76 5739 4927 5110 -261 -1609 -544 0

ATOM 3735 OE2 GLU c 76 14.033 -29. .078 -30. .959 1. .00 49. .19 0

ANISOU 3735 OE2 GLU c 76 4472 8151 6065 721 -901 -839 0

ATOM 3736 N THR c 77 11.366 -24. .213 -27. .483 1. .00 14. .91 N

ANISOU 3736 N THR c 77 1380 2211 2072 15 -173 -167 N

ATOM 3737 CA THR c 77 10.301 -23. .288 -27. .062 1. .00 15. .99 C

ANISOU 3737 CA THR c 77 1782 2372 1919 229 -304 -466 C

ATOM 3738 C THR c 77 10.763 -21. .832 -27. .068 1. .00 18. .07 c

ANISOU 3738 C THR c 77 2030 2290 2543 392 -527 -158 c

ATOM 3739 O THR c 77 9.946 -20. .914 -27. .197 1. .00 20. .98 0

ANISOU 3739 O THR c 77 2408 2673 2888 865 -259 -397 0

ATOM 3740 CB THR c 77 9.786 -23. .611 -25. .644 1. .00 15. .90 c ANISOU 3740 CB THR C 77 1265 2582 2193 -162 -108 -297 C

ATOM 3741 OG1 THR C 77 10.886 -23. .538 -24. .728 1. .00 15. .15 O

ANISOU 3741 OG1 THR C 77 1119 2279 2357 -58 -137 -500 O

ATOM 3742 CG2 THR C 77 9.185 -25. .003 -25. .568 1. .00 16. .98 C

ANISOU 3742 CG2 THR C 77 694 2844 2913 -363 -406 -571 C

ATOM 3743 N GLY C 78 12.070 -21. .620 -26. .914 1. .00 16. .44 N

ANISOU 3743 N GLY C 78 1940 2320 1983 202 -169 -162 N

ATOM 3744 CA GLY C 78 12.603 -20. .283 -26. .711 1. .00 17. .35 C

ANISOU 3744 CA GLY C 78 2240 2390 1960 244 -491 -237 C

ATOM 3745 C GLY C 78 12.644 -19. .864 -25. .252 1. .00 14. .59 C

ANISOU 3745 C GLY C 78 1609 2196 1739 297 -200 67 C

ATOM 3746 O GLY C 78 13.015 -18. .736 -24. .955 1. .00 16. .38 O

ANISOU 3746 O GLY C 78 1773 2662 1787 101 -482 -314 O

ATOM 3747 N GLU C 79 12.282 -20. .768 -24. .341 1. .00 14. .48 N

ANISOU 3747 N GLU C 79 1527 2181 1794 -97 -385 -96 N

ATOM 3748 CA GLU C 79 12.285 -20. .464 -22. .896 1. .00 13. .18 C

ANISOU 3748 CA GLU C 79 1250 2042 1713 -55 -113 118 C

ATOM 3749 C GLU c 79 13.682 -20. .216 -22. .328 1. .00 11. .95 C

ANISOU 3749 C GLU c 79 1396 1502 1641 -272 -115 -200 C

ATOM 3750 O GLU c 79 14.633 -20. .915 -22. .682 1. .00 12. .36 O

ANISOU 3750 O GLU c 79 1364 1760 1571 95 -419 -33 O

ATOM 3751 CB GLU c 79 11.673 -21. .622 -22. .087 1. .00 15. .12 C

ANISOU 3751 CB GLU c 79 1242 2192 2308 -475 27 82 C

ATOM 3752 CG GLU c 79 10.159 -21. .749 -22. .174 1. .00 16. .40 c

ANISOU 3752 CG GLU c 79 1179 2368 2684 -212 187 -175 c

ATOM 3753 CD GLU c 79 9.675 -23. .093 -21. .662 1. .00 19. .08 c

ANISOU 3753 CD GLU c 79 1897 2295 3055 -310 482 -246 c

ATOM 3754 OE1 GLU c 79 9.956 -24. .130 -22. .315 1. .00 18. .07 0

ANISOU 3754 OE1 GLU c 79 1874 2572 2418 -553 -210 -482 0

ATOM 3755 OE2 GLU c 79 8.993 -23. .121 -20. .615 1. .00 23. .61 0

ANISOU 3755 OE2 GLU c 79 3107 3156 2705 -358 548 -383 0

ATOM 3756 N THR c 80 13.762 -19. .245 -21. .416 1. .00 11. .54 N

ANISOU 3756 N THR c 80 1204 1757 1423 -325 -148 -288 N

ATOM 3757 CA THR c 80 14.953 -18. .988 -20. .589 1. .00 11. .30 C

ANISOU 3757 CA THR c 80 1052 1768 1470 39 -185 -123 C

ATOM 3758 C THR c 80 14.639 -19. .558 -19. .209 1. .00 11. .10 C

ANISOU 3758 C THR c 80 1185 1627 1405 158 -285 -191 C

ATOM 3759 O THR c 80 13.731 -19. .061 -18. .535 1. .00 10. .87 0

ANISOU 3759 O THR c 80 898 1840 1392 -152 -103 -169 0

ATOM 3760 CB THR c 80 15.246 -17. .478 -20. .449 1. .00 11. .16 c

ANISOU 3760 CB THR c 80 1232 1800 1208 -97 -257 -108 c

ATOM 3761 OG1 THR c 80 15.479 -16. .890 -21. .736 1. .00 10. .70 0

ANISOU 3761 OG1 THR c 80 1113 1691 1261 -123 -17 -163 0

ATOM 3762 CG2 THR c 80 16.502 -17. .224 -19. .559 1. .00 11. .03 c

ANISOU 3762 CG2 THR c 80 975 1628 1584 -20 -236 -70 c

ATOM 3763 N CYS c 81 15.406 -20. .560 -18. .781 1. .00 11. .51 N

ANISOU 3763 N CYS c 81 1252 1435 1683 -88 -247 208 N

ATOM 3764 CA CYS c 81 15.133 -21. .269 -17. .520 1. .00 11. .51 C

ANISOU 3764 CA CYS c 81 1220 1813 1339 -184 -191 -48 C

ATOM 3765 C CYS c 81 16.268 -21. .043 -16. .538 1. .00 12. .94 C

ANISOU 3765 C CYS c 81 1628 1759 1527 -87 -450 -394 C

ATOM 3766 O CYS c 81 17.432 -21. .373 -16. .826 1. .00 14. .20 0

ANISOU 3766 O CYS c 81 1595 1920 1879 -234 -239 -250 0

ATOM 3767 CB CYS c 81 14.924 -22. .753 -17. .760 1. .00 13. .64 c

ANISOU 3767 CB CYS c 81 1750 1838 1592 -198 -168 -223 c

ATOM 3768 SG CYS c 81 13.400 -23. .079 -18. .684 1. .00 18. .22 s

ANISOU 3768 SG CYS c 81 2197 2395 2329 -304 -656 -191 s

ATOM 3769 N ILE c 82 15.933 -20. .439 -15. .397 1. .00 13. .48 N

ANISOU 3769 N ILE c 82 1777 1955 1387 -343 -183 -220 N

ATOM 3770 CA ILE c 82 16.939 -20. .079 -14. .391 1. .00 11. .77 C

ANISOU 3770 CA ILE c 82 1272 1775 1423 -186 -114 -3 C ATOM 3771 C ILE C 82 16.794 -21.,039 -13..213 1..00 12..82 C

ANISOU 3771 C ILE C 82 1382 1680 1807 -47 24 186 C

ATOM 3772 O ILE C 82 15.707 -21. ,124 -12. .595 1. .00 12. .10 O

ANISOU 3772 O ILE C 82 1223 1764 1610 -92 -112 95 O

ATOM 3773 CB ILE C 82 16.798 -18. ,613 -13. .906 1. .00 11. .71 C

ANISOU 3773 CB ILE C 82 1303 1875 1268 -43 -79 -75 C

ATOM 3774 CGI ILE C 82 16.704 -17. ,618 -15. .075 1. .00 11. .97 C

ANISOU 3774 CGI ILE C 82 1607 1686 1252 -161 201 -170 C

ATOM 3775 CG2 ILE C 82 17.941 -18. ,229 -12. .965 1. .00 12. .09 C

ANISOU 3775 CG2 ILE C 82 1314 1796 1483 -293 -104 -38 C

ATOM 3776 CD1 ILE C 82 16.348 -16. ,200 -14. .651 1. .00 14. .36 C

ANISOU 3776 CD1 ILE C 82 1630 1774 2052 289 252 30 C

ATOM 3777 N SER C 83 17.876 -21. ,739 -12. .873 1. .00 12. .64 N

ANISOU 3777 N SER C 83 1540 1469 1791 47 -91 -105 N

ATOM 3778 CA SER C 83 17.828 -22. ,720 -11. .790 1. .00 14. .26 C

ANISOU 3778 CA SER C 83 1636 1649 2133 -173 93 161 C

ATOM 3779 C SER C 83 17.801 -22. ,082 -10. .400 1. .00 14. .77 C

ANISOU 3779 C SER c 83 1819 1829 1961 -318 -79 354 C

ATOM 3780 O SER c 83 18.333 -20. ,976 -10. .187 1. .00 15. .54 O

ANISOU 3780 O SER c 83 1736 2105 2063 -537 -274 323 O

ATOM 3781 CB SER c 83 19.006 -23. ,694 -11. .892 1. .00 18. .08 C

ANISOU 3781 CB SER c 83 2564 1637 2669 295 206 -4 C

ATOM 3782 OG SER c 83 18.906 -24. ,464 -13. .075 1. .00 23. .17 O

ANISOU 3782 OG SER c 83 3399 2400 3006 602 398 -542 0

ATOM 3783 N ALA c 84 17.178 -22. ,768 -9. .452 1. .00 15. .82 N

ANISOU 3783 N ALA c 84 1562 2571 1877 -531 -44 362 N

ATOM 3784 CA ALA c 84 17.257 -22. ,336 -8. .067 1. .00 16. .98 C

ANISOU 3784 CA ALA c 84 1767 2818 1864 -849 83 300 C

ATOM 3785 C ALA c 84 18.592 -22. ,741 -7. .473 1. .00 18. .75 C

ANISOU 3785 C ALA c 84 1852 2942 2328 -975 -232 282 C

ATOM 3786 O ALA c 84 19.169 -23. ,759 -7. .857 1. .00 20. .32 O

ANISOU 3786 O ALA c 84 1603 3357 2758 -458 -790 518 O

ATOM 3787 CB ALA c 84 16.126 -22. ,920 -7. .236 1. .00 17. .35 C

ANISOU 3787 CB ALA c 84 1097 3306 2189 -1075 -170 138 c

ATOM 3788 N ASN c 85 19.077 -21. ,951 -6. .528 1. .00 21. .29 N

ANISOU 3788 N ASN c 85 2719 2876 2494 -1168 -980 546 N

ATOM 3789 CA ASN c 85 20.336 -22. ,268 -5. .873 1. .00 28. .62 C

ANISOU 3789 CA ASN c 85 3270 4245 3356 -644 -1418 476 C

ATOM 3790 C ASN c 85 20.256 -21. ,911 -4. .391 1. .00 31. .70 C

ANISOU 3790 C ASN c 85 4649 3777 3618 -519 -1550 -340 C

ATOM 3791 O ASN c 85 20.284 -20. ,723 -4. .063 1. .00 43. .67 O

ANISOU 3791 O ASN c 85 5502 4119 6969 -842 -2362 - 1116 O

ATOM 3792 CB ASN c 85 21.483 -21. ,514 -6. .565 1. .00 31. .39 C

ANISOU 3792 CB ASN c 85 3002 4530 4395 -909 -1555 481 c

ATOM 3793 CG ASN c 85 22.814 -22. ,209 -6. .410 1. .00 38. .03 c

ANISOU 3793 CG ASN c 85 3452 5013 5985 -429 -554 -619 c

ATOM 3794 OD1 ASN c 85 23.099 -22. ,823 -5. .377 1. .00 44. .29 0

ANISOU 3794 OD1 ASN c 85 3960 6659 6209 -576 -1111 -44 0

ATOM 3795 ND2 ASN c 85 23.643 -22. ,120 -7. .439 1. .00 43. .01 N

ANISOU 3795 ND2 ASN c 85 5851 4446 6042 -2172 146 - 1249 N

ATOM 3796 N PRO c 86 20.151 -22. ,923 -3. .490 1. .00 30. .96 N

ANISOU 3796 N PRO c 86 4507 4469 2786 -137 -777 -242 N

ATOM 3797 CA PRO c 86 20.138 -24. ,373 -3. .747 1. .00 26. .29 C

ANISOU 3797 CA PRO c 86 3649 4179 2158 -622 -981 172 C

ATOM 3798 C PRO c 86 18.900 -24. ,887 -4. .472 1. .00 24. .10 C

ANISOU 3798 C PRO c 86 2231 4137 2789 -56 -436 546 C

ATOM 3799 O PRO c 86 17.803 -24. ,313 -4. .349 1. .00 22. .53 O

ANISOU 3799 O PRO c 86 1728 4254 2577 -309 -474 957 O

ATOM 3800 CB PRO c 86 20.213 -24. ,997 -2. .339 1. .00 28. .76 C

ANISOU 3800 CB PRO c 86 3649 4810 2468 -416 -694 551 C

ATOM 3801 CG PRO c 86 19.750 -23. ,930 -1. .415 1. .00 30. .93 C ANISOU 3801 CG PRO C 86 3705 4950 3097 -330 171 568 C

ATOM 3802 CD PRO C 86 20.203 -22. ,641 -2. .040 1. .00 32. .62 C

ANISOU 3802 CD PRO C 86 5187 4413 2790 -736 -315 -69 C

ATOM 3803 N LEU C 87 19.088 -25. ,974 -5. .203 1. .00 23. .11 N

ANISOU 3803 N LEU C 87 2484 4104 2192 -362 -861 520 N

ATOM 3804 CA LEU C 87 18.048 -26. ,628 -5. .966 1. .00 23. .70 C

ANISOU 3804 CA LEU C 87 2639 3529 2835 -869 -238 -174 C

ATOM 3805 C LEU C 87 17.136 -27. ,428 -5. .060 1. .00 23. .18 C

ANISOU 3805 C LEU C 87 2102 3896 2809 -275 -561 757 C

ATOM 3806 O LEU C 87 16.027 -27. ,741 -5. .395 1. .00 26. .44 O

ANISOU 3806 O LEU C 87 2452 3378 4214 -203 -1391 1063 O

ATOM 3807 CB LEU C 87 18.703 -27. ,569 -6. .979 1. .00 24. .51 C

ANISOU 3807 CB LEU C 87 2577 3762 2973 -310 187 173 C

ATOM 3808 CG LEU C 87 17.947 -28. ,682 -7. .700 1. .00 25. .38 C

ANISOU 3808 CG LEU C 87 3468 3176 2998 252 180 -92 c

ATOM 3809 CD1 LEU C 87 17.820 -29. ,968 -6. .899 1. .00 30. .15 c

ANISOU 3809 CD1 LEU C 87 4218 3403 3834 -294 115 157 c

ATOM 3810 CD2 LEU c 87 16.592 -28. ,286 -8. .273 1. .00 28. .85 c

ANISOU 3810 CD2 LEU c 87 3738 4441 2783 -345 452 319 c

ATOM 3811 N ASN c 88 17.624 -27. ,803 -3. .905 1. .00 21. .16 N

ANISOU 3811 N ASN c 88 1522 4025 2492 -618 -173 786 N

ATOM 3812 CA ASN c 88 16.855 -28. ,745 -3. .146 1. .00 20. .42 C

ANISOU 3812 CA ASN c 88 1903 3737 2119 -425 208 445 C

ATOM 3813 C ASN c 88 16.839 -28. ,552 -1. .638 1. .00 22. .93 C

ANISOU 3813 C ASN c 88 1949 4739 2021 -415 -199 792 C

ATOM 3814 O ASN c 88 17.771 -27. ,997 -1. .037 1. .00 20. .47 O

ANISOU 3814 O ASN c 88 2011 3519 2246 203 -331 330 0

ATOM 3815 CB ASN c 88 17.206 -30. ,183 -3. .558 1. .00 25. .92 c

ANISOU 3815 CB ASN c 88 3576 2834 3436 -829 613 1539 c

ATOM 3816 CG ASN c 88 18.272 -30. ,799 -2. .690 1. .00 30. .95 c

ANISOU 3816 CG ASN c 88 3237 4383 4137 405 484 207 c

ATOM 3817 OD1 ASN c 88 18.006 -31. ,746 -1. .945 1. .00 41. .04 0

ANISOU 3817 OD1 ASN c 88 5016 4287 6291 367 2377 559 0

ATOM 3818 ND2 ASN c 88 19.484 -30. ,262 -2. .764 1. .00 41. .53 N

ANISOU 3818 ND2 ASN c 88 4203 5489 6084 -582 1543 353 N

ATOM 3819 N VAL c 89 15.709 -28. ,955 -1. .070 1. .00 23. .30 N

ANISOU 3819 N VAL c 89 2128 4412 2311 -811 -224 661 N

ATOM 3820 CA VAL c 89 15.510 -29. ,013 0. .360 1. .00 22. .03 C

ANISOU 3820 CA VAL c 89 2106 3985 2278 -213 -213 815 C

ATOM 3821 C VAL c 89 15.615 -30. ,500 0. .711 1. .00 22. .00 C

ANISOU 3821 C VAL c 89 1896 3796 2665 -280 -855 825 C

ATOM 3822 O VAL c 89 14.783 -31. ,292 0. .264 1. .00 19. .57 O

ANISOU 3822 O VAL c 89 1638 3668 2126 -300 -314 754 O

ATOM 3823 CB VAL c 89 14.130 -28. ,442 0. .743 1. .00 19. .67 C

ANISOU 3823 CB VAL c 89 1741 4087 1647 -354 -652 746 C

ATOM 3824 CGI VAL c 89 13.859 -28. ,602 2. .239 1. .00 21. .43 C

ANISOU 3824 CGI VAL c 89 2011 4382 1747 -263 -394 807 C

ATOM 3825 CG2 VAL c 89 14.024 -26. ,981 0. .322 1. .00 20. .66 c

ANISOU 3825 CG2 VAL c 89 2031 3820 1997 -294 -934 164 c

ATOM 3826 N PRO c 90 16.646 -30. ,890 1. .495 1. .00 24. .24 N

ANISOU 3826 N PRO c 90 1768 4523 2918 64 -739 901 N

ATOM 3827 CA PRO c 90 16.815 -32. ,324 1. .795 1. .00 23. .01 C

ANISOU 3827 CA PRO c 90 1875 4189 2678 -45 -690 738 C

ATOM 3828 C PRO c 90 15.606 -32. ,901 2. .543 1. .00 22. .98 C

ANISOU 3828 C PRO c 90 1955 3841 2933 233 -694 924 C

ATOM 3829 O PRO c 90 14.910 -32. ,172 3. .261 1. .00 23. .32 O

ANISOU 3829 O PRO c 90 1668 4410 2782 220 -275 885 O

ATOM 3830 CB PRO c 90 18.076 -32. ,373 2. .696 1. .00 25. .97 c

ANISOU 3830 CB PRO c 90 1973 4471 3422 581 -917 967 c

ATOM 3831 CG PRO c 90 18.696 -31. ,014 2. .625 1. .00 25. .87 c

ANISOU 3831 CG PRO c 90 1854 4306 3667 660 -347 311 c ATOM 3832 CD PRO C 90 17.648 -30..040 2..175 1..00 22..11 C

ANISOU 3832 CD PRO C 90 1567 4261 2572 61 -493 972 C

ATOM 3833 N ARG C 91 15.352 -34. .198 2. .359 1. .00 26. .17 N

ANISOU 3833 N ARG C 91 2602 3806 3534 -195 -689 1424 N

ATOM 3834 CA ARG C 91 14.272 -34. .881 3. .076 1. .00 27. .04 C

ANISOU 3834 CA ARG C 91 2794 4044 3434 -103 -520 1316 C

ATOM 3835 C ARG C 91 14.619 -35. .024 4. .556 1. .00 28. .35 C

ANISOU 3835 C ARG C 91 2056 4863 3852 1754 -731 1530 C

ATOM 3836 O ARG C 91 15.610 -35. .662 4. .909 1. .00 28. .29 O

ANISOU 3836 O ARG C 91 2289 3694 4765 1245 -1599 1975 O

ATOM 3837 CB ARG C 91 14.026 -36. .261 2. .480 1. .00 25. .90 C

ANISOU 3837 CB ARG C 91 2557 3454 3827 95 -567 1485 C

ATOM 3838 CG ARG C 91 13.706 -36. .277 0. .997 1. .00 30. .17 C

ANISOU 3838 CG ARG C 91 3206 4297 3960 -301 -931 716 c

ATOM 3839 CD ARG C 91 14.235 -37. .580 0. .430 1. .00 38. .14 c

ANISOU 3839 CD ARG C 91 4393 4707 5389 637 145 970 c

ATOM 3840 NE ARG C 91 13.338 -38. .190 -0. .547 1. .00 47. .20 N

ANISOU 3840 NE ARG c 91 5192 5996 6743 358 -443 869 N

ATOM 3841 CZ ARG c 91 13.314 -39. .496 -0. .827 1. .00 37. .13 C

ANISOU 3841 CZ ARG c 91 3296 5405 5404 3397 -537 2020 C

ATOM 3842 NH1 ARG c 91 14.130 -40. .340 -0. .197 1. .00 47. .65 N

ANISOU 3842 NH1 ARG c 91 4570 6484 7048 3953 -1052 2166 N

ATOM 3843 NH2 ARG c 91 12.465 -39. .960 -1. .737 1. .00 46. .53 N

ANISOU 3843 NH2 ARG c 91 3375 7294 7007 944 872 259 N

ATOM 3844 N LYS c 92 13.792 -34. .437 5. .416 1. .00 28. .01 N

ANISOU 3844 N LYS c 92 2549 5560 2533 487 -149 1303 N

ATOM 3845 CA LYS c 92 14.074 -34. .410 6. .853 1. .00 31. .76 C

ANISOU 3845 CA LYS c 92 3614 5916 2538 -243 162 1210 C

ATOM 3846 C LYS c 92 12.751 -34. .244 7. .582 1. .00 29. .53 C

ANISOU 3846 C LYS c 92 2810 5957 2450 124 -615 814 C

ATOM 3847 O LYS c 92 11.744 -33. .875 6. .970 1. .00 25. .69 O

ANISOU 3847 O LYS c 92 2291 4805 2663 -223 -172 1343 O

ATOM 3848 CB LYS c 92 15.015 -33. .232 7. .172 1. .00 34. .52 C

ANISOU 3848 CB LYS c 92 2500 6619 3994 -183 -378 796 C

ATOM 3849 CG LYS c 92 15.889 -33. .373 8. .409 1. .00 42. .02 C

ANISOU 3849 CG LYS c 92 4439 7207 4316 -330 -1057 799 C

ATOM 3850 CD LYS c 92 16.895 -32. .230 8. .517 1. .00 47. .65 C

ANISOU 3850 CD LYS c 92 5683 6971 5449 -845 -1133 392 C

ATOM 3851 CE LYS c 92 16.256 -30. .946 9. .034 1. .00 46. .57 C

ANISOU 3851 CE LYS c 92 5383 7131 5181 -333 -1147 1037 C

ATOM 3852 NZ LYS c 92 17.250 -29. .848 9. .220 1. .00 45. .80 N

ANISOU 3852 NZ LYS c 92 6323 6144 4933 33 -2638 2056 N

ATOM 3853 N HIS c 93 12.748 -34. .549 8. .877 1. .00 34. .98 N

ANISOU 3853 N HIS c 93 4671 6033 2586 -220 -870 958 N

ATOM 3854 CA HIS c 93 11.704 -34. .084 9. .771 1. .00 30. .45 C

ANISOU 3854 CA HIS c 93 4374 5370 1822 -908 -1056 861 C

ATOM 3855 C HIS c 93 12.063 -32. .663 10. .081 1. .00 28. .58 C

ANISOU 3855 C HIS c 93 3693 5157 2008 -366 -1120 681 C

ATOM 3856 O HIS c 93 13.017 -32. .415 10. .830 1. .00 35. .92 O

ANISOU 3856 O HIS c 93 3950 6927 2768 -588 -1431 244 O

ATOM 3857 CB HIS c 93 11.673 -34. .926 11. .049 1. .00 35. .11 C

ANISOU 3857 CB HIS c 93 4964 6393 1980 -624 -968 1287 C

ATOM 3858 CG HIS c 93 10.650 -34. .466 12. .051 1. .00 37. .03 C

ANISOU 3858 CG HIS c 93 5422 6474 2172 -1197 -378 1695 C

ATOM 3859 ND1 HIS c 93 9.331 -34. .730 11. .917 1. .00 42. .52 N

ANISOU 3859 ND1 HIS c 93 5789 7035 3330 -2028 -599 805 N

ATOM 3860 CD2 HIS c 93 10.790 -33. .740 13. .237 1. .00 45. .42 C

ANISOU 3860 CD2 HIS c 93 6686 7443 3127 -1493 -34 620 C

ATOM 3861 CE1 HIS c 93 8.662 -34. .200 12. .962 1. .00 41. .89 C

ANISOU 3861 CE1 HIS c 93 4956 6799 4158 -1763 314 1481 C

ATOM 3862 NE2 HIS c 93 9.556 -33. .595 13. .769 1. .00 45. .49 N ANISOU 3862 NE2 HIS C 93 6526 7785 2973 -1343 -205 1001 N

ATOM 3863 N TRP C 94 11.318 -31. .724 9. .499 1. .00 28. .13 N

ANISOU 3863 N TRP C 94 3654 4945 2087 -304 -614 847 N

ATOM 3864 CA TRP C 94 11.668 -30. .301 9. .531 1. .00 25. .33 C

ANISOU 3864 CA TRP C 94 2495 4664 2464 278 -593 814 C

ATOM 3865 C TRP C 94 11.007 -29. .512 10. .619 1. .00 28. .70 C

ANISOU 3865 C TRP C 94 3720 5089 2095 -624 -328 481 C

ATOM 3866 O TRP C 94 11.557 -28. .507 11. .080 1. .00 32. .13 O

ANISOU 3866 O TRP C 94 3918 5357 2930 -812 -834 437 O

ATOM 3867 CB TRP C 94 11.326 -29. .646 8. .194 1. .00 24. .27 C

ANISOU 3867 CB TRP C 94 2179 4603 2437 -190 -672 882 C

ATOM 3868 CG TRP C 94 12.332 -29. .927 7. .116 1. .00 23. .80 C

ANISOU 3868 CG TRP C 94 2439 4362 2241 -952 -651 722 C

ATOM 3869 CD1 TRP C 94 12.259 -30. .882 6. .104 1. .00 23. .82 C

ANISOU 3869 CD1 TRP C 94 2059 4681 2307 -806 -643 369 C

ATOM 3870 CD2 TRP C 94 13.622 -29. .262 6. .924 1. .00 23. .38 C

ANISOU 3870 CD2 TRP C 94 2221 4106 2556 -767 -597 701 C

ATOM 3871 NE1 TRP C 94 13.380 -30. .842 5. .308 1. .00 24. .52 N

ANISOU 3871 NE1 TRP C 94 2351 4576 2386 -1322 -485 1045 N

ATOM 3872 CE2 TRP C 94 14.237 -29. .890 5. .745 1. .00 24. .31 C

ANISOU 3872 CE2 TRP C 94 2334 4259 2643 -1073 -386 652 C

ATOM 3873 CE3 TRP C 94 14.301 -28. .234 7. .577 1. .00 25. .64 C

ANISOU 3873 CE3 TRP c 94 2981 3885 2874 -469 -776 233 C

ATOM 3874 CZ2 TRP c 94 15.488 -29. .499 5. .275 1. .00 23. .37 C

ANISOU 3874 CZ2 TRP c 94 2470 4371 2039 -564 102 847 C

ATOM 3875 CZ3 TRP c 94 15.554 -27. .848 7. .087 1. .00 27. .26 C

ANISOU 3875 CZ3 TRP c 94 2942 4797 2617 -101 -584 563 C

ATOM 3876 CH2 TRP c 94 16.130 -28. .465 5. .964 1. .00 26. .37 c

ANISOU 3876 CH2 TRP c 94 2839 4640 2540 -541 -324 577 c

ATOM 3877 N TRP c 95 9.815 -29. .950 11. .021 1. .00 28. .94 N

ANISOU 3877 N TRP c 95 2745 5892 2355 -23 -593 158 N

ATOM 3878 CA TRP c 95 8.940 -29. .164 11. .872 1. .00 29. .81 C

ANISOU 3878 CA TRP c 95 3801 5642 1883 -391 -470 -217 C

ATOM 3879 C TRP c 95 8.360 -30. .013 12. .972 1. .00 35. .27 C

ANISOU 3879 C TRP c 95 5121 5298 2978 -811 -91 67 C

ATOM 3880 O TRP c 95 7.995 -31. .169 12. .741 1. .00 35. .02 O

ANISOU 3880 O TRP c 95 4968 5216 3120 -817 -442 438 O

ATOM 3881 CB TRP c 95 7.821 -28. .582 11. .011 1. .00 30. .25 C

ANISOU 3881 CB TRP c 95 3537 5297 2658 -63 -350 -326 c

ATOM 3882 CG TRP c 95 6.838 -27. .736 11. .775 1. .00 30. .09 c

ANISOU 3882 CG TRP c 95 3655 4802 2974 -867 180 -829 c

ATOM 3883 CD1 TRP c 95 5.514 -28. .045 12. .098 1. .00 29. .91 c

ANISOU 3883 CD1 TRP c 95 3773 5294 2297 -475 528 -286 c

ATOM 3884 CD2 TRP c 95 7.078 -26. .409 12. .358 1. .00 28. .16 c

ANISOU 3884 CD2 TRP c 95 4039 4817 1842 -807 -398 -657 c

ATOM 3885 NE1 TRP c 95 4.938 -27. .022 12. .814 1. .00 28. .82 N

ANISOU 3885 NE1 TRP c 95 2714 5182 3053 -718 987 -155 N

ATOM 3886 CE2 TRP c 95 5.822 -26. .012 13. .008 1. .00 31. .76 C

ANISOU 3886 CE2 TRP c 95 3826 5122 3120 -978 -155 -655 C

ATOM 3887 CE3 TRP c 95 8.167 -25. .539 12. .400 1. .00 32. .78 C

ANISOU 3887 CE3 TRP c 95 4786 5372 2295 -1516 -717 -387 C

ATOM 3888 CZ2 TRP c 95 5.687 -24. .792 13. .663 1. .00 32. .09 c

ANISOU 3888 CZ2 TRP c 95 3969 5092 3130 -891 -743 -701 c

ATOM 3889 CZ3 TRP c 95 8.017 -24. .314 13. .065 1. .00 37. .66 c

ANISOU 3889 CZ3 TRP c 95 5544 6048 2717 -1337 -281 - 1101 c

ATOM 3890 CH2 TRP c 95 6.807 -23. .949 13. .677 1. .00 34. .27 c

ANISOU 3890 CH2 TRP c 95 4347 5863 2811 -1447 -1143 -684 c

ATOM 3891 N THR c 96 8.278 -29. .443 14. .175 1. .00 40. .93 N

ANISOU 3891 N THR c 96 6498 6171 2881 -575 563 71 N

ATOM 3892 CA THR c 96 7.629 -30. .083 15. .329 1. .00 39. .59 C

ANISOU 3892 CA THR c 96 6356 5558 3125 -323 157 613 C ATOM 3893 C THR C 96 6.599 -29..129 15..929 1..00 45..74 C

ANISOU 3893 C THR c 96 8816 5269 3291 251 759 -235 C

ATOM 3894 O THR c 96 6.963 -28. .125 16. .548 1. .00 48. .59 O

ANISOU 3894 O THR c 96 9464 6308 2687 -391 1177 -848 O

ATOM 3895 CB THR c 96 8.653 -30. .481 16. .421 1. .00 43. .63 C

ANISOU 3895 CB THR c 96 6575 6747 3252 20 -27 318 C

ATOM 3896 OG1 THR c 96 9.581 -31. .435 15. .888 1. .00 48. .65 O

ANISOU 3896 OG1 THR c 96 7477 6148 4858 884 -707 307 O

ATOM 3897 CG2 THR c 96 7.952 -31. .091 17. .643 1. .00 43. .39 C

ANISOU 3897 CG2 THR c 96 6641 6507 3337 -722 580 -561 C

ATOM 3898 N LYS c 102 -2.799 -28. .076 13. .580 1. .00 34. .57 N

ANISOU 3898 N LYS c 102 2524 6705 3903 -447 774 2075 N

ATOM 3899 CA LYS c 102 -2.152 -27. .911 12. .280 1. .00 36. .97 C

ANISOU 3899 CA LYS c 102 4291 7029 2724 -804 116 1185 C

ATOM 3900 C LYS c 102 -2.444 -26. .538 11. .668 1. .00 35. .07 C

ANISOU 3900 C LYS c 102 3909 6514 2901 -1398 618 886 C

ATOM 3901 O LYS c 102 -3.552 -26. .006 11. .790 1. .00 36. .34 O

ANISOU 3901 O LYS c 102 3358 8054 2394 -1683 601 -196 O

ATOM 3902 CB LYS c 102 -2.589 -29. .015 11. .308 1. .00 36. .60 C

ANISOU 3902 CB LYS c 102 4825 5431 3647 -489 429 1433 C

ATOM 3903 CG LYS c 102 -2.203 -30. .433 11. .698 1. .00 41. .28 c

ANISOU 3903 CG LYS c 102 5404 6191 4087 906 -321 1487 c

ATOM 3904 CD LYS c 102 -0.938 -30. .890 10. .990 1. .00 42. .31 c

ANISOU 3904 CD LYS c 102 6477 6209 3387 -472 1152 1464 c

ATOM 3905 CE LYS c 102 -0.850 -32. .410 10. .903 1. .00 45. .03 c

ANISOU 3905 CE LYS c 102 6634 6240 4233 -791 792 682 c

ATOM 3906 NZ LYS c 102 -0.056 -33. .045 11. .993 1. .00 39. .28 N

ANISOU 3906 NZ LYS c 102 6082 6215 2624 -431 796 - 1062 N

ATOM 3907 N LYS c 103 -1.431 -25. .967 11. .023 1. .00 33. .53 N

ANISOU 3907 N LYS c 103 3480 6262 2995 -1925 19 516 N

ATOM 3908 CA LYS c 103 -1.568 -24. .726 10. .269 1. .00 30. .49 C

ANISOU 3908 CA LYS c 103 3781 5259 2544 -1391 305 -468 C

ATOM 3909 C LYS c 103 -0.524 -24. .773 9. .172 1. .00 28. .27 C

ANISOU 3909 C LYS c 103 3844 4668 2227 -1511 138 229 C

ATOM 3910 O LYS c 103 0.422 -25. .565 9. .251 1. .00 31. .04 O

ANISOU 3910 O LYS c 103 4165 5400 2228 -1435 -608 48 O

ATOM 3911 CB LYS c 103 -1.322 -23. .513 11. .169 1. .00 31. .83 C

ANISOU 3911 CB LYS c 103 4398 4762 2932 -732 1384 -706 C

ATOM 3912 N HIS c 104 -0.686 -23. .965 8. .130 1. .00 21. .42 N

ANISOU 3912 N HIS c 104 3022 3068 2048 -1132 204 -433 N

ATOM 3913 CA HIS c 104 0.401 -23. .838 7. .160 1. .00 22. .01 C

ANISOU 3913 CA HIS c 104 2694 3771 1897 -733 88 -562 C

ATOM 3914 C HIS c 104 1.605 -23. .230 7. .833 1. .00 22. .17 C

ANISOU 3914 C HIS c 104 2732 3393 2296 -709 27 -530 C

ATOM 3915 O HIS c 104 1.473 -22. .291 8. .623 1. .00 25. .11 O

ANISOU 3915 O HIS c 104 3662 3681 2195 -655 612 -601 O

ATOM 3916 CB HIS c 104 -0.024 -23. .009 5. .958 1. .00 21. .22 C

ANISOU 3916 CB HIS c 104 2444 3386 2232 -481 -179 -685 C

ATOM 3917 CG HIS c 104 -1.081 -23. .669 5. .113 1. .00 21. .48 c

ANISOU 3917 CG HIS c 104 2593 3300 2267 -343 -207 -900 c

ATOM 3918 ND1 HIS c 104 -0.784 -24. .540 4. .114 1. .00 19. .67 N

ANISOU 3918 ND1 HIS c 104 2177 3494 1803 -692 374 -556 N

ATOM 3919 CD2 HIS c 104 -2.467 -23. .549 5. .133 1. .00 19. .83 C

ANISOU 3919 CD2 HIS c 104 2467 3136 1929 -680 266 -860 C

ATOM 3920 CE1 HIS c 104 -1.925 -24. .949 3. .526 1. .00 16. .78 C

ANISOU 3920 CE1 HIS c 104 2225 2674 1475 -773 420 -210 C

ATOM 3921 NE2 HIS c 104 -2.954 -24. .343 4. .153 1. .00 23. .52 N

ANISOU 3921 NE2 HIS c 104 2704 3544 2687 -572 189 - 1428 N

ATOM 3922 N VAL c 105 2.790 -23. .780 7. .566 1. .00 22. .52 N

ANISOU 3922 N VAL c 105 2766 3674 2115 -857 417 -369 N

ATOM 3923 CA VAL c 105 4.032 -23. .254 8. .139 1. .00 20. .49 C ANISOU 3923 CA VAL C 105 2416 3489 1880 -959 420 522 C

ATOM 3924 C VAL C 105 5.030 -22. ,991 7. .013 1. .00 21. .59 C

ANISOU 3924 C VAL C 105 2492 3835 1876 -766 668 -136 C

ATOM 3925 O VAL C 105 5.406 -23. ,921 6. .295 1. .00 22. .70 O

ANISOU 3925 O VAL C 105 3454 3478 1691 -689 -247 -179 O

ATOM 3926 CB VAL C 105 4.665 -24. ,233 9. .157 1. .00 23. .10 C

ANISOU 3926 CB VAL C 105 2638 3802 2333 -1168 -358 466 C

ATOM 3927 CGI VAL C 105 5.966 -23. ,655 9. .733 1. .00 21. .85 C

ANISOU 3927 CGI VAL C 105 2659 3838 1803 -1174 -105 -4 C

ATOM 3928 CG2 VAL C 105 3.674 -24. ,586 10. .270 1. .00 28. .03 C

ANISOU 3928 CG2 VAL C 105 3239 4653 2757 -1500 -21 620 C

ATOM 3929 N TRP C 106 5.471 -21. ,741 6. .869 1. .00 24. .66 N

ANISOU 3929 N TRP C 106 3286 3770 2312 -748 704 38 N

ATOM 3930 CA TRP C 106 6.473 -21. ,409 5. .841 1. .00 20. .27 C

ANISOU 3930 CA TRP C 106 3111 2871 1719 -775 499 -626 C

ATOM 3931 C TRP C 106 7.823 -21. ,974 6. .156 1. .00 23. .25 C

ANISOU 3931 C TRP C 106 3581 3146 2104 -540 230 -895 C

ATOM 3932 O TRP C 106 8.395 -21. ,688 7. .220 1. .00 24. .79 O

ANISOU 3932 O TRP C 106 3831 3699 1888 -941 189 -481 O

ATOM 3933 CB TRP C 106 6.554 -19. ,901 5. .609 1. .00 22. .92 C

ANISOU 3933 CB TRP C 106 3398 2755 2554 -800 125 -840 C

ATOM 3934 CG TRP C 106 5.292 -19. ,362 4. .995 1. .00 22. .17 c

ANISOU 3934 CG TRP C 106 3157 2665 2600 -383 439 - 1220 c

ATOM 3935 CD1 TRP C 106 4.304 -18. ,591 5. .605 1. .00 27. .25 c

ANISOU 3935 CD1 TRP c 106 4132 3245 2976 684 337 - 1020 c

ATOM 3936 CD2 TRP c 106 4.817 -19. ,572 3. .617 1. .00 23. .45 c

ANISOU 3936 CD2 TRP c 106 3325 2942 2640 -189 280 -848 c

ATOM 3937 NE1 TRP c 106 3.284 -18. ,321 4. .726 1. .00 30. .68 N

ANISOU 3937 NE1 TRP c 106 3933 4258 3464 224 178 - 1186 N

ATOM 3938 CE2 TRP c 106 3.535 -18. ,875 3. .515 1. .00 25. .90 C

ANISOU 3938 CE2 TRP c 106 3618 3017 3203 30 -135 -862 C

ATOM 3939 CE3 TRP c 106 5.313 -20. ,245 2. .500 1. .00 20. .74 C

ANISOU 3939 CE3 TRP c 106 3200 2585 2096 -62 195 -211 C

ATOM 3940 CZ2 TRP c 106 2.798 -18. ,869 2. .344 1. .00 24. .66 C

ANISOU 3940 CZ2 TRP c 106 3948 3192 2228 -424 549 -868 c

ATOM 3941 CZ3 TRP c 106 4.561 -20. ,231 1. .328 1. .00 19. .57 c

ANISOU 3941 CZ3 TRP c 106 2840 2493 2103 -525 251 -742 c

ATOM 3942 CH2 TRP c 106 3.338 -19. ,551 1. .252 1. .00 20. .82 c

ANISOU 3942 CH2 TRP c 106 3365 2274 2270 -120 29 -769 c

ATOM 3943 N PHE c 107 8.344 -22. ,781 5. .232 1. .00 20. .59 N

ANISOU 3943 N PHE c 107 2660 3578 1585 -357 321 -523 N

ATOM 3944 CA PHE c 107 9.703 -23. ,346 5. .347 1. .00 22. .12 C

ANISOU 3944 CA PHE c 107 2723 3289 2390 -596 -191 -645 C

ATOM 3945 C PHE c 107 10.782 -22. ,276 5. .555 1. .00 24. .39 C

ANISOU 3945 C PHE c 107 3485 3353 2426 -1019 -201 -372 C

ATOM 3946 O PHE c 107 11.553 -22. ,357 6. .510 1. .00 29. .10 O

ANISOU 3946 O PHE c 107 3362 4902 2791 -2033 -462 -417 0

ATOM 3947 CB PHE c 107 10.029 -24. ,222 4. .124 1. .00 19. .61 c

ANISOU 3947 CB PHE c 107 2431 3497 1523 -336 -167 -48 c

ATOM 3948 CG PHE c 107 11.465 -24. ,678 4. .061 1. .00 19. .40 c

ANISOU 3948 CG PHE c 107 2207 3328 1836 -656 -307 56 c

ATOM 3949 CD1 PHE c 107 11.932 -25. ,718 4. .879 1. .00 21. .83 c

ANISOU 3949 CD1 PHE c 107 2035 3788 2470 -324 -865 82 c

ATOM 3950 CD2 PHE c 107 12.357 -24. ,066 3. .187 1. .00 21. .70 c

ANISOU 3950 CD2 PHE c 107 2088 3946 2209 -693 -183 242 c

ATOM 3951 CE1 PHE c 107 13.268 -26. ,124 4. .824 1. .00 19. .27 c

ANISOU 3951 CE1 PHE c 107 1932 3531 1858 -649 -272 353 c

ATOM 3952 CE2 PHE c 107 13.682 -24. ,476 3. .125 1. .00 17. .58 c

ANISOU 3952 CE2 PHE c 107 1754 3373 1553 -928 -654 110 c

ATOM 3953 CZ PHE c 107 14.137 -25. ,504 3. .941 1. .00 18. .41 c

ANISOU 3953 CZ PHE c 107 1903 3578 1514 -670 -360 266 c ATOM 3954 N GLY C 108 10.841 -21..290 4..657 1..00 24..17 N

ANISOU 3954 N GLY C 108 3537 3142 2502 -1317 -411 -362 N

ATOM 3955 CA GLY C 108 11.868 -20. .242 4. .722 1. .00 26. .71 C

ANISOU 3955 CA GLY C 108 3010 3854 3284 -1402 -573 -527 C

ATOM 3956 C GLY C 108 11.671 -19. .298 5. .890 1. .00 29. .84 C

ANISOU 3956 C GLY C 108 3378 4211 3749 -1211 10 -755 C

ATOM 3957 O GLY C 108 12.630 -18. .949 6. .590 1. .00 33. .61 O

ANISOU 3957 O GLY C 108 3445 5027 4297 -2216 588 - 1593 O

ATOM 3958 N GLU C 109 10.427 -18. .884 6. .108 1. .00 27. .68 N

ANISOU 3958 N GLU C 109 2936 3956 3622 -1641 -23 99 N

ATOM 3959 CA GLU C 109 10.123 -17. .896 7. .144 1. .00 33. .33 C

ANISOU 3959 CA GLU C 109 4084 4306 4271 -1529 -78 -399 C

ATOM 3960 C GLU C 109 10.236 -18. .447 8. .559 1. .00 34. .61 C

ANISOU 3960 C GLU C 109 4922 4437 3788 -1869 -249 -939 C

ATOM 3961 O GLU C 109 10.713 -17. .754 9. .449 1. .00 36. .96 O

ANISOU 3961 O GLU C 109 4509 5370 4163 -1265 -326 - 1692 O

ATOM 3962 CB GLU C 109 8.726 -17. .309 6. .944 1. .00 38. .20 C

ANISOU 3962 CB GLU C 109 4779 4632 5101 -443 99 -182 C

ATOM 3963 CG GLU c 109 8.669 -16. .132 5. .980 1. .00 49. .23 c

ANISOU 3963 CG GLU c 109 6844 5583 6278 156 -17 541 c

ATOM 3964 CD GLU c 109 7.273 -15. .538 5. .847 1. .00 54. .13 c

ANISOU 3964 CD GLU c 109 7043 6087 7436 471 216 745 c

ATOM 3965 OE1 GLU c 109 6.474 -15. .651 6. .804 1. .00 59. .41 0

ANISOU 3965 OE1 GLU c 109 9538 4936 8097 -1373 1549 93 0

ATOM 3966 OE2 GLU c 109 6.973 -14. .948 4. .786 1. .00 50. .64 0

ANISOU 3966 OE2 GLU c 109 4761 6804 7675 1043 -977 500 0

ATOM 3967 N SER c 110 9.823 -19. .699 8. .756 1. .00 28. .73 N

ANISOU 3967 N SER c 110 3705 4674 2534 -2154 -461 - 1075 N

ATOM 3968 CA SER c 110 9.535 -20. .202 10. .103 1. .00 30. .50 C

ANISOU 3968 CA SER c 110 3925 5012 2650 -1340 -526 -668 C

ATOM 3969 C SER c 110 10.278 -21. .450 10. .558 1. .00 32. .22 C

ANISOU 3969 C SER c 110 4470 5315 2456 -996 -751 -847 C

ATOM 3970 O SER c 110 10.302 -21. .736 11. .756 1. .00 38. .40 0

ANISOU 3970 O SER c 110 5792 6616 2180 -1206 -422 - 1156 0

ATOM 3971 CB SER c 110 8.033 -20. .446 10. .253 1. .00 30. .97 c

ANISOU 3971 CB SER c 110 4057 5079 2631 -1167 592 -855 c

ATOM 3972 OG SER c 110 7.311 -19. .256 10. .018 1. .00 34. .91 0

ANISOU 3972 OG SER c 110 4405 5206 3651 -1253 644 - 1552 0

ATOM 3973 N MET c 111 10.861 -22. .207 9. .634 1. .00 26. .08 N

ANISOU 3973 N MET c 111 2255 5671 1983 -1529 -255 -229 N

ATOM 3974 CA MET c 111 11.465 -23. .491 10. .018 1. .00 27. .28 C

ANISOU 3974 CA MET c 111 3713 4739 1909 -1876 -399 -872 C

ATOM 3975 C MET c 111 12.953 -23. .385 10. .341 1. .00 33. .84 C

ANISOU 3975 C MET c 111 4026 6187 2643 -1205 -1447 -397 C

ATOM 3976 O MET c 111 13.662 -22. .560 9. .761 1. .00 38. .16 O

ANISOU 3976 O MET c 111 4749 7370 2378 -1866 -1164 -619 0

ATOM 3977 CB MET c 111 11.199 -24. .568 8. .963 1. .00 25. .75 c

ANISOU 3977 CB MET c 111 3052 4824 1906 -1895 -273 -966 c

ATOM 3978 CG MET c 111 9.717 -24. .872 8. .766 1. .00 27. .42 c

ANISOU 3978 CG MET c 111 3045 4543 2829 -1430 -843 -829 c

ATOM 3979 SD MET c 111 9.434 -26. .340 7. .766 1. .00 24. .50 s

ANISOU 3979 SD MET c 111 2635 4304 2368 -1266 -451 -412 s

ATOM 3980 CE MET c 111 7.721 -26. .077 7. .300 1. .00 22. .18 c

ANISOU 3980 CE MET c 111 2158 3857 2409 -1289 220 -244 c

ATOM 3981 N ASP c 112 13.417 -24. .209 11. .279 1. .00 32. .44 N

ANISOU 3981 N ASP c 112 3325 5984 3015 -1268 -1381 -231 N

ATOM 3982 CA ASP c 112 14.837 -24. .227 11. .644 1. .00 32. .46 C

ANISOU 3982 CA ASP c 112 3464 6465 2402 -1346 -1561 -122 C

ATOM 3983 C ASP c 112 15.678 -24. .823 10. .514 1. .00 33. .37 C

ANISOU 3983 C ASP c 112 3091 6625 2961 -1425 -1224 -71 C

ATOM 3984 O ASP c 112 15.454 -25. .961 10. .095 1. .00 35. .08 0 ANISOU 3984 O ASP C 112 3458 6837 3034 -898 -1588 -150 O

ATOM 3985 CB ASP C 112 15.055 -24. .986 12. .955 1. .00 34. .07 C

ANISOU 3985 CB ASP C 112 3968 6274 2702 -1243 -875 344 C

ATOM 3986 N GLY C 113 16.635 -24. .042 10. .015 1. .00 34. .47 N

ANISOU 3986 N GLY C 113 3422 7122 2551 -1490 -477 -571 N

ATOM 3987 CA GLY C 113 17.414 -24. .425 8. .840 1. .00 29. .55 C

ANISOU 3987 CA GLY C 113 2645 6282 2298 -1197 -638 160 C

ATOM 3988 C GLY C 113 16.714 -24. .066 7. .543 1. .00 27. .67 C

ANISOU 3988 C GLY C 113 2432 6038 2043 -1764 -757 -507 C

ATOM 3989 O GLY C 113 17.223 -24. .356 6. .463 1. .00 28. .79 O

ANISOU 3989 O GLY C 113 2193 6510 2234 -1082 -285 452 O

ATOM 3990 N GLY C 114 15.545 -23. .430 7. .645 1. .00 28. .12 N

ANISOU 3990 N GLY C 114 2998 5964 1720 -1444 -575 305 N

ATOM 3991 CA GLY C 114 14.778 -23. .019 6. .468 1. .00 23. .08 C

ANISOU 3991 CA GLY C 114 2560 4487 1720 -1516 -398 57 C

ATOM 3992 C GLY C 114 15.462 -21. .877 5. .738 1. .00 26. .51 C

ANISOU 3992 C GLY C 114 3093 4640 2338 -1740 -153 186 C

ATOM 3993 O GLY C 114 16.300 -21. .160 6. .308 1. .00 31. .11 O

ANISOU 3993 O GLY C 114 2618 5915 3284 -1136 -923 -476 O

ATOM 3994 N PHE C 115 15.116 -21. .726 4. .465 1. .00 22. .78 N

ANISOU 3994 N PHE C 115 1930 4199 2523 -1159 -384 -72 N

ATOM 3995 CA PHE C 115 15.632 -20. .657 3. .612 1. .00 23. .86 C

ANISOU 3995 CA PHE C 115 2646 3906 2511 -870 23 -223 C

ATOM 3996 C PHE C 115 14.622 -20. .382 2. .508 1. .00 25. .08 C

ANISOU 3996 C PHE C 115 3133 4117 2279 -956 -31 -181 C

ATOM 3997 O PHE C 115 13.872 -21. .274 2. .110 1. .00 27. .83 O

ANISOU 3997 O PHE c 115 3318 4769 2485 -1182 -841 169 O

ATOM 3998 CB PHE c 115 17.003 -21. .025 3. .011 1. .00 25. .81 C

ANISOU 3998 CB PHE c 115 2385 4506 2915 -873 -136 -124 C

ATOM 3999 CG PHE c 115 17.037 -22. .371 2. .314 1. .00 24. .32 c

ANISOU 3999 CG PHE c 115 2350 4738 2151 -705 57 -124 c

ATOM 4000 CD1 PHE c 115 16.669 -22. .490 0. .976 1. .00 25. .88 c

ANISOU 4000 CD1 PHE c 115 2381 5218 2231 -587 -172 59 c

ATOM 4001 CD2 PHE c 115 17.457 -23. .520 2. .993 1. .00 27. .42 c

ANISOU 4001 CD2 PHE c 115 2869 4320 3228 -729 -20 -89 c

ATOM 4002 CE1 PHE c 115 16.701 -23. .730 0. .336 1. .00 28. .03 c

ANISOU 4002 CE1 PHE c 115 2767 4269 3613 4 109 745 c

ATOM 4003 CE2 PHE c 115 17.492 -24. .756 2. .359 1. .00 23. .75 c

ANISOU 4003 CE2 PHE c 115 2070 3868 3083 -155 199 373 c

ATOM 4004 CZ PHE c 115 17.118 -24. .862 1. .027 1. .00 25. .32 c

ANISOU 4004 CZ PHE c 115 2276 4300 3042 -207 270 876 c

ATOM 4005 N GLN c 116 14.588 -19. .147 2. .023 1. .00 23. .52 N

ANISOU 4005 N GLN c 116 3198 4056 1682 -1029 -14 -516 N

ATOM 4006 CA GLN c 116 13.765 -18. .835 0. .868 1. .00 23. .54 C

ANISOU 4006 CA GLN c 116 3277 3754 1911 -937 -140 -633 C

ATOM 4007 C GLN c 116 14.553 -19. .130 -0. .406 1. .00 22. .93 c

ANISOU 4007 C GLN c 116 2844 3866 2002 -1346 -58 -407 c

ATOM 4008 O GLN c 116 15.795 -19. .174 -0. .385 1. .00 25. .29 0

ANISOU 4008 O GLN c 116 2932 4658 2017 -902 -211 -865 0

ATOM 4009 CB GLN c 116 13.221 -17. .410 0. .942 1. .00 26. .18 c

ANISOU 4009 CB GLN c 116 3900 3731 2315 -786 583 -713 c

ATOM 4010 CG GLN c 116 12.363 -17. .220 2. .193 1. .00 28. .40 c

ANISOU 4010 CG GLN c 116 3816 4828 2145 -594 531 47 c

ATOM 4011 CD GLN c 116 11.355 -16. .106 2. .050 1. .00 34. .68 c

ANISOU 4011 CD GLN c 116 5868 3538 3769 -382 533 -30 c

ATOM 4012 OE1 GLN c 116 11.601 -15. .119 1. .360 1. .00 39. .22 0

ANISOU 4012 OE1 GLN c 116 5799 3788 5314 -1060 728 500 0

ATOM 4013 NE2 GLN c 116 10.200 -16. .265 2. .699 1. .00 37. .76 N

ANISOU 4013 NE2 GLN c 116 6463 3761 4120 -1468 833 - 1673 N

ATOM 4014 N PHE c 117 13.842 -19. .378 -1. .502 1. .00 22. .57 N

ANISOU 4014 N PHE c 117 3607 3227 1741 -1012 -42 -715 N ATOM 4015 CA PHE C 117 14.524 -19..842 -2..708 1..00 19., 98 C

ANISOU 4015 CA PHE C 117 2323 3173 2094 -998 -97 -632 C

ATOM 4016 C PHE C 117 15.149 -18. .694 -3. .464 1. .00 19. ,16 C

ANISOU 4016 C PHE C 117 1804 3201 2273 -738 -5 -455 C

ATOM 4017 O PHE C 117 14.595 -17. .605 -3. .523 1. .00 23. , 00 O

ANISOU 4017 O PHE C 117 2690 2900 3147 -883 691 -260 O

ATOM 4018 CB PHE C 117 13.611 -20. .696 -3. .600 1. .00 19. , 67 C

ANISOU 4018 CB PHE C 117 2733 2098 2642 -1152 -61 -578 C

ATOM 4019 CG PHE C 117 12.861 -21. .766 -2. .841 1. .00 21. , 05 C

ANISOU 4019 CG PHE C 117 2420 2447 3132 -1052 -214 -73 C

ATOM 4020 CD1 PHE C 117 13.525 -22. .602 -1. .929 1. .00 21. ,76 C

ANISOU 4020 CD1 PHE C 117 2644 3005 2619 -1168 -397 -163 C

ATOM 4021 CD2 PHE C 117 11.502 -21. .939 -3. .034 1. .00 18. , 94 C

ANISOU 4021 CD2 PHE C 117 2233 2299 2663 -822 -101 -255 C

ATOM 4022 CE1 PHE C 117 12.838 -23. .582 -1. .230 1. .00 24. , 35 C

ANISOU 4022 CE1 PHE C 117 3346 3320 2585 -1053 -143 101 C

ATOM 4023 CE2 PHE C 117 10.805 -22. .917 -2. .335 1. .00 20. , 05 C

ANISOU 4023 CE2 PHE C 117 3244 2152 2222 -628 332 -260 C

ATOM 4024 CZ PHE C 117 11.473 -23. .740 -1. .431 1. .00 21. , 95 C

ANISOU 4024 CZ PHE C 117 2962 3204 2170 -1193 458 493 C

ATOM 4025 N SER C 118 16.336 -18. .950 -4. .003 1. .00 18. ,89 N

ANISOU 4025 N SER C 118 1799 3285 2093 -988 63 -889 N

ATOM 4026 CA SER c 118 17.066 -17. .950 -4. .751 1. .00 21. ,16 C

ANISOU 4026 CA SER c 118 2394 3584 2060 -961 274 -601 C

ATOM 4027 C SER c 118 17.413 -18. .443 -6. .145 1. .00 21. , 80 C

ANISOU 4027 C SER c 118 2841 3366 2074 -1107 432 -457 C

ATOM 4028 O SER c 118 17.547 -19. .658 -6. .370 1. .00 22. , 38 O

ANISOU 4028 O SER c 118 1995 3670 2839 -628 227 -948 O

ATOM 4029 CB SER c 118 18.342 -17. .581 -4. .018 1. .00 27. , 48 C

ANISOU 4029 CB SER c 118 2767 4995 2680 -1807 250 - 1405 C

ATOM 4030 OG SER c 118 18.877 -16. .441 -4. .632 1. .00 35. ,71 0

ANISOU 4030 OG SER c 118 3691 5296 4581 -1953 51 - 1095 0

ATOM 4031 N TYR c 119 17.578 -17. .499 -7. .075 1. .00 19. ,26 N

ANISOU 4031 N TYR c 119 2033 3277 2007 -993 741 -437 N

ATOM 4032 CA TYR c 119 17.754 -17. .850 -8. .489 1. .00 19. , 70 C

ANISOU 4032 CA TYR c 119 1803 3678 2002 -958 895 -394 C

ATOM 4033 C TYR c 119 18.821 -17. .041 -9. .172 1. .00 23. , 22 C

ANISOU 4033 C TYR c 119 2938 3353 2529 -1511 949 -169 C

ATOM 4034 O TYR c 119 18.887 -15. .809 -9. .020 1. .00 29. , 93 O

ANISOU 4034 O TYR c 119 3846 3432 4092 -2270 1317 -246 O

ATOM 4035 CB TYR c 119 16.450 -17. .683 -9. .252 1. .00 18. , 35 C

ANISOU 4035 CB TYR c 119 2092 2428 2452 -1038 592 -161 c

ATOM 4036 CG TYR c 119 15.336 -18. .514 -8. .655 1. .00 14. , 57 c

ANISOU 4036 CG TYR c 119 1780 2122 1633 -651 576 -214 c

ATOM 4037 CD1 TYR c 119 14.622 -18. .063 -7. .535 1. .00 15. ,26 c

ANISOU 4037 CD1 TYR c 119 1849 2394 1555 -402 417 -275 c

ATOM 4038 CD2 TYR c 119 15.006 -19. .745 -9. .200 1. .00 14. ,16 c

ANISOU 4038 CD2 TYR c 119 1674 2152 1553 -349 67 -226 c

ATOM 4039 CE1 TYR c 119 13.623 -18. .832 -6. .972 1. .00 15. , 66 c

ANISOU 4039 CE1 TYR c 119 2194 1885 1871 -457 130 115 c

ATOM 4040 CE2 TYR c 119 13.993 -20. .515 -8. .653 1. .00 14. ,16 c

ANISOU 4040 CE2 TYR c 119 1708 2022 1650 -268 147 -98 c

ATOM 4041 CZ TYR c 119 13.308 -20. .051 -7. .537 1. .00 15. , 93 c

ANISOU 4041 CZ TYR c 119 2224 2127 1699 -213 188 -246 c

ATOM 4042 OH TYR c 119 12.295 -20. .811 -6. .995 1. .00 16. , 17 0

ANISOU 4042 OH TYR c 119 2499 1589 2056 -205 -204 369 0

ATOM 4043 N GLY c 120 19.647 -17. .741 -9. .942 1. .00 20. , 10 N

ANISOU 4043 N GLY c 120 1768 4088 1780 -1141 110 -351 N

ATOM 4044 CA GLY c 120 20.681 -17. .090 -10. .722 1. .00 22. , 34 C

ANISOU 4044 CA GLY c 120 1528 4613 2348 -1390 -165 52 c

ATOM 4045 C GLY c 120 21.979 -17. .045 -9. .955 1. .00 22. , 61 c ANISOU 4045 C GLY C 120 1162 4934 2493 -790 64 -191 C

ATOM 4046 O GLY C 120 21.998 -17. ,317 -8. .763 1. .00 23. .82 O

ANISOU 4046 O GLY C 120 1849 4723 2479 -864 -256 -371 O

ATOM 4047 N ASN C 121 23.054 -16. ,677 -10. .647 1. .00 21. .31 N

ANISOU 4047 N ASN C 121 1559 4326 2212 -1493 7 -612 N

ATOM 4048 CA ASN C 121 24.416 -16. ,792 -10. .129 1. .00 21. .29 C

ANISOU 4048 CA ASN C 121 1920 3250 2919 -1050 -568 -505 C

ATOM 4049 C ASN C 121 24.491 -16. ,303 -8. .681 1. .00 18. .51 C

ANISOU 4049 C ASN C 121 1337 2975 2720 -517 -627 -44 C

ATOM 4050 O ASN C 121 24.273 -15. ,132 -8. .432 1. .00 20. .36 O

ANISOU 4050 O ASN C 121 1411 3355 2969 10 -797 -505 O

ATOM 4051 CB ASN C 121 25.376 -15. ,955 -10. .991 1. .00 23. .35 C

ANISOU 4051 CB ASN C 121 1973 3905 2990 -733 -121 -352 C

ATOM 4052 CG ASN C 121 25.569 -16. ,510 -12. .389 1. .00 24. .06 c

ANISOU 4052 CG ASN C 121 2258 4038 2845 -750 -810 -352 c

ATOM 4053 OD1 ASN C 121 26.699 -16. ,725 -12. .815 1. .00 34. .18 0

ANISOU 4053 OD1 ASN C 121 2965 5512 4509 -871 392 -140 0

ATOM 4054 ND2 ASN C 121 24.474 -16. ,724 -13. .119 1. .00 13. .34 N

ANISOU 4054 ND2 ASN C 121 1588 1483 1995 -471 -275 431 N

ATOM 4055 N PRO C 122 24.799 -17. ,204 -7. .730 1. .00 21. .39 N

ANISOU 4055 N PRO C 122 1973 3278 2874 -413 -735 229 N

ATOM 4056 CA PRO C 122 24.789 -16. ,857 -6. .306 1. .00 19. .74 C

ANISOU 4056 CA PRO C 122 1584 2873 3041 41 -1455 31 C

ATOM 4057 C PRO c 122 25.787 -15. ,756 -5. .957 1. .00 19. .61 C

ANISOU 4057 C PRO c 122 2325 2598 2528 -129 -1252 -120 C

ATOM 4058 O PRO c 122 25.578 -15. ,010 -4. .989 1. .00 20. .22 O

ANISOU 4058 O PRO c 122 2323 2361 2996 124 -1749 -461 O

ATOM 4059 CB PRO c 122 25.151 -18. ,179 -5. .614 1. .00 22. .63 C

ANISOU 4059 CB PRO c 122 2831 2543 3223 -447 -703 265 C

ATOM 4060 CG PRO c 122 24.793 -19. ,236 -6. .590 1. .00 23. .91 C

ANISOU 4060 CG PRO c 122 3259 3491 2332 -460 -952 138 C

ATOM 4061 CD PRO c 122 25.053 -18. ,641 -7. .948 1. .00 23. .15 C

ANISOU 4061 CD PRO c 122 2706 3178 2912 -641 -807 310 c

ATOM 4062 N GLU c 123 26.841 -15. ,622 -6. .764 1. .00 17. .88 N

ANISOU 4062 N GLU c 123 1592 2076 3126 212 -1459 -57 N

ATOM 4063 CA GLU c 123 27.834 -14. ,581 -6. .518 1. .00 19. .35 C

ANISOU 4063 CA GLU c 123 2570 1430 3352 107 -1552 -8 C

ATOM 4064 C GLU c 123 27.331 -13. ,165 -6. .859 1. .00 16. .72 C

ANISOU 4064 C GLU c 123 2239 1663 2449 407 -1277 -26 C

ATOM 4065 O GLU c 123 27.944 -12. ,182 -6. .465 1. .00 21. .47 O

ANISOU 4065 O GLU c 123 2724 2421 3012 -117 -1689 -161 O

ATOM 4066 CB GLU c 123 29.159 -14. ,904 -7. .221 1. .00 25. .09 c

ANISOU 4066 CB GLU c 123 2146 2988 4399 -751 -1516 -615 c

ATOM 4067 CG GLU c 123 29.145 -14. ,840 -8. .743 1. .00 31. .01 c

ANISOU 4067 CG GLU c 123 4392 2792 4597 759 -963 701 c

ATOM 4068 CD GLU c 123 28.607 -16. ,097 -9. .440 1. .00 37. .39 c

ANISOU 4068 CD GLU c 123 4704 4192 5310 11 -533 -99 c

ATOM 4069 OE1 GLU c 123 28.054 -17. ,025 -8. .786 1. .00 32. .31 0

ANISOU 4069 OE1 GLU c 123 3901 3879 4493 893 -526 312 0

ATOM 4070 OE2 GLU c 123 28.741 -16. ,159 -10. .686 1. .00 41. .34 0

ANISOU 4070 OE2 GLU c 123 4756 5464 5487 496 -444 -392 0

ATOM 4071 N LEU c 124 26.204 -13. ,054 -7. .557 1. .00 15. .45 N

ANISOU 4071 N LEU c 124 1879 2168 1821 -61 -881 -329 N

ATOM 4072 CA LEU c 124 25.681 -11. ,728 -7. .934 1. .00 15. .33 C

ANISOU 4072 CA LEU c 124 1972 2064 1787 -28 -478 -196 C

ATOM 4073 C LEU c 124 24.879 -11. ,110 -6. .790 1. .00 15. .79 C

ANISOU 4073 C LEU c 124 2355 2005 1638 57 -549 -187 c

ATOM 4074 O LEU c 124 24.160 -11. ,820 -6. .090 1. .00 17. .66 0

ANISOU 4074 O LEU c 124 2685 2093 1931 332 -159 -294 0

ATOM 4075 CB LEU c 124 24.812 -11. ,791 -9. .207 1. .00 17. .95 c

ANISOU 4075 CB LEU c 124 2602 2675 1539 -65 -501 -37 c ATOM 4076 CG LEU C 124 25.479 -11..990 -10..578 1..00 22..52 C

ANISOU 4076 CG LEU c 124 3110 3887 1556 -590 -552 -325 C

ATOM 4077 CD1 LEU c 124 24.422 -12. .141 -11. .664 1. .00 22. .76 C

ANISOU 4077 CD1 LEU c 124 3153 3795 1698 87 -778 -178 C

ATOM 4078 CD2 LEU c 124 26.417 -10. .843 -10. .927 1. .00 22. .36 C

ANISOU 4078 CD2 LEU c 124 3554 2509 2432 95 -828 334 C

ATOM 4079 N PRO c 125 24.989 -9. .784 -6. .607 1. .00 14. .63 N

ANISOU 4079 N PRO c 125 1991 1950 1615 22 -414 -29 N

ATOM 4080 CA PRO c 125 24.214 -9. .108 -5. .576 1. .00 14. .00 C

ANISOU 4080 CA PRO c 125 1698 1936 1685 -105 -175 260 C

ATOM 4081 C PRO c 125 22.730 -9. .311 -5. .820 1. .00 15. .02 C

ANISOU 4081 C PRO c 125 1809 2256 1639 -292 -402 68 C

ATOM 4082 O PRO c 125 22.293 -9. .366 -6. .979 1. .00 13. .98 O

ANISOU 4082 O PRO c 125 1520 2330 1461 88 -71 50 O

ATOM 4083 CB PRO c 125 24.560 -7. .626 -5. .790 1. .00 15. .32 C

ANISOU 4083 CB PRO c 125 1482 1940 2396 -268 -312 225 C

ATOM 4084 CG PRO c 125 25.925 -7. .653 -6. .436 1. .00 16. .59 C

ANISOU 4084 CG PRO c 125 1970 1943 2388 -89 158 188 c

ATOM 4085 CD PRO c 125 25.860 -8. .850 -7. .345 1. .00 16. .41 c

ANISOU 4085 CD PRO c 125 2463 1998 1775 132 -205 383 c

ATOM 4086 N GLU c 126 21.940 -9. .371 -4. .750 1. .00 16. .61 N

ANISOU 4086 N GLU c 126 1701 2726 1883 -13 -380 722 N

ATOM 4087 CA GLU c 126 20.497 -9. .577 -4. .867 1. .00 17. .21 C

ANISOU 4087 CA GLU c 126 1767 2889 1881 -65 -401 354 C

ATOM 4088 C GLU c 126 19.843 -8. .513 -5. .733 1. .00 14. .85 C

ANISOU 4088 C GLU c 126 1834 2312 1494 -138 -184 152 C

ATOM 4089 O GLU c 126 18.956 -8. .797 -6. .484 1. .00 15. .01 O

ANISOU 4089 O GLU c 126 1864 2225 1612 3 -306 124 O

ATOM 4090 CB GLU c 126 19.767 -9. .525 -3. .523 1. .00 23. .61 c

ANISOU 4090 CB GLU c 126 3123 3700 2145 332 303 750 c

ATOM 4091 CG GLU c 126 20.089 -10. .618 -2. .552 1. .00 21. .63 c

ANISOU 4091 CG GLU c 126 3485 2727 2005 1463 795 -974 c

ATOM 4092 CD GLU c 126 19.141 -10. .637 -1. .346 1. .00 35. .02 c

ANISOU 4092 CD GLU c 126 5027 4355 3922 3334 831 - 1393 c

ATOM 4093 OE1 GLU c 126 18.467 -9. .622 -1. .082 1. .00 47. .33 0

ANISOU 4093 OE1 GLU c 126 4735 6328 6920 2288 -754 1059 0

ATOM 4094 OE2 GLU c 126 19.080 -11. .676 -0. .673 1. .00 49. .63 0

ANISOU 4094 OE2 GLU c 126 7657 7390 3809 Ill 1675 1277 0

ATOM 4095 N ASP c 127 20.257 -7. .276 -5. .561 1. .00 13. .44 N

ANISOU 4095 N ASP c 127 1335 2226 1544 23 -370 124 N

ATOM 4096 CA ASP c 127 19.638 -6. .195 -6. .343 1. .00 15. .06 C

ANISOU 4096 CA ASP c 127 2003 1973 1747 19 -303 164 C

ATOM 4097 C ASP c 127 19.859 -6. .374 -7. .845 1. .00 14. .29 C

ANISOU 4097 C ASP c 127 1739 1951 1740 131 -293 173 c

ATOM 4098 O ASP c 127 18.988 -6. .066 -8. .634 1. .00 14. .21 0

ANISOU 4098 O ASP c 127 1810 2023 1563 144 -322 21 0

ATOM 4099 CB ASP c 127 20.124 -4. .815 -5. .892 1. .00 15. .55 c

ANISOU 4099 CB ASP c 127 1920 1878 2109 11 -166 185 c

ATOM 4100 CG ASP c 127 21.634 -4. .682 -5. .947 1. .00 15. .17 c

ANISOU 4100 CG ASP c 127 1920 1882 1961 113 -355 370 c

ATOM 4101 OD1 ASP c 127 22.328 -5. .286 -5. .103 1. .00 17. .80 0

ANISOU 4101 OD1 ASP c 127 2227 2362 2173 449 -386 523 0

ATOM 4102 OD2 ASP c 127 22.126 -3. .958 -6. .828 1. .00 13. .48 0

ANISOU 4102 OD2 ASP c 127 1144 1921 2057 231 -232 213 0

ATOM 4103 N VAL c 128 21.021 -6. .896 -8. .224 1. .00 13. .87 N

ANISOU 4103 N VAL c 128 1324 2182 1761 -116 -419 128 N

ATOM 4104 CA VAL c 128 21.347 -7. .152 -9. .616 1. .00 13. .89 C

ANISOU 4104 CA VAL c 128 1529 1900 1849 116 -335 122 C

ATOM 4105 C VAL c 128 20.486 -8. .294 -10. .152 1. .00 13. .70 c

ANISOU 4105 C VAL c 128 1375 1935 1893 135 -81 102 c

ATOM 4106 O VAL c 128 19.925 -8. .190 -11. .258 1. .00 14. .52 0 ANISOU 4106 O VAL C 128 1556 2290 1670 -32 45 ^■124 O

ATOM 4107 CB VAL C 128 22.873 -7. .422 -9. .785 1. .00 14. .47 C

ANISOU 4107 CB VAL C 128 1491 1575 2430 -291 -12 -13 C

ATOM 4108 CGI VAL C 128 23.209 -7. .834 -11. .206 1. .00 16. .15 C

ANISOU 4108 CGI VAL C 128 1689 2138 2307 101 - 316 -21 C

ATOM 4109 CG2 VAL C 128 23.670 -6. .175 -9. .395 1. .00 15. .52 C

ANISOU 4109 CG2 VAL C 128 2197 1042 2658 -60 124 ^■268 C

ATOM 4110 N LEU C 129 20.362 -9. .372 -9. .375 1. .00 12. .99 N

ANISOU 4110 N LEU C 129 1240 1710 1986 -128 12 -91 N

ATOM 4111 CA LEU C 129 19.492 -10. .477 -9. .761 1. .00 13. .66 C

ANISOU 4111 CA LEU C 129 1615 1613 1962 -159 - 120 -7 C

ATOM 4112 C LEU C 129 18.055 -9. .969 -9. .918 1. .00 13. .88 C

ANISOU 4112 C LEU C 129 1707 1617 1950 55 - 120 -29 C

ATOM 4113 O LEU C 129 17.366 -10. .355 -10. .877 1. .00 15. .12 O

ANISOU 4113 O LEU C 129 1668 1863 2214 -93 - 163 -63 O

ATOM 4114 CB LEU C 129 19.570 -11. .628 -8. .746 1. .00 15. .50 C

ANISOU 4114 CB LEU C 129 2109 1689 2090 177 253 116 C

ATOM 4115 CG LEU C 129 20.952 -12. .307 -8. .682 1. .00 20. .09 C

ANISOU 4115 CG LEU C 129 2654 2282 2695 724 253 99 c

ATOM 4116 CD1 LEU C 129 21.079 -13. .315 -7. .533 1. .00 22. .20 c

ANISOU 4116 CD1 LEU C 129 2550 2624 3259 342 292 639 c

ATOM 4117 CD2 LEU C 129 21.293 -12. .954 -10. .029 1. .00 20. .66 c

ANISOU 4117 CD2 LEU C 129 2127 3047 2675 194 236 ^■242 c

ATOM 4118 N ASP C 130 17.622 -9. .090 -9. .009 1. .00 14. .02 N

ANISOU 4118 N ASP C 130 1540 1894 1893 286 28 94 N

ATOM 4119 CA ASP C 130 16.263 -8. .510 -9. .065 1. .00 14. .23 C

ANISOU 4119 CA ASP C 130 1722 1852 1833 464 - 371 0 C

ATOM 4120 C ASP c 130 16.050 -7. .775 -10. .374 1. .00 12. .39 C

ANISOU 4120 C ASP c 130 1109 1887 1712 68 - 233 32 C

ATOM 4121 O ASP c 130 15.004 -7. .927 -11. .019 1. .00 13. .14 O

ANISOU 4121 O ASP c 130 1234 1904 1854 -7 - 452 266 0

ATOM 4122 CB ASP c 130 16.009 -7. .504 -7. .923 1. .00 18. .21 c

ANISOU 4122 CB ASP c 130 2562 2340 2015 314 33 ^■293 c

ATOM 4123 CG ASP c 130 15.725 -8. .152 -6. .593 1. .00 22. .04 c

ANISOU 4123 CG ASP c 130 3005 2843 2523 405 449 33 c

ATOM 4124 OD1 ASP c 130 15.586 -9. .390 -6. .513 1. .00 22. .23 0

ANISOU 4124 OD1 ASP c 130 2906 2876 2664 -19 211 197 0

ATOM 4125 OD2 ASP c 130 15.630 -7. .383 -5. .601 1. .00 29. .18 0

ANISOU 4125 OD2 ASP c 130 4286 4647 2152 821 769 ^■281 0

ATOM 4126 N VAL c 131 17.035 -6. .985 -10. .772 1. .00 12. .06 N

ANISOU 4126 N VAL c 131 1610 1290 1680 52 - 205 120 N

ATOM 4127 CA VAL c 131 16.933 -6. .207 -12. .009 1. .00 11. .38 C

ANISOU 4127 CA VAL c 131 1597 1035 1689 268 - 207 48 C

ATOM 4128 C VAL c 131 16.909 -7. .131 -13. .236 1. .00 12. .15 C

ANISOU 4128 C VAL c 131 1522 1223 1872 314 -67 ^■117 C

ATOM 4129 O VAL c 131 16.104 -6. .946 -14. .143 1. .00 13. .35 0

ANISOU 4129 O VAL c 131 1733 1454 1884 164 -79 42 0

ATOM 4130 CB VAL c 131 18.050 -5. .142 -12. .114 1. .00 11. .39 c

ANISOU 4130 CB VAL c 131 1718 1011 1599 272 89 ^■137 c

ATOM 4131 CGI VAL c 131 18.135 -4. .575 -13. .532 1. .00 11. .79 c

ANISOU 4131 CGI VAL c 131 1500 1510 1470 344 7 ^■261 c

ATOM 4132 CG2 VAL c 131 17.791 -4. .019 -11. .105 1. .00 11. .20 c

ANISOU 4132 CG2 VAL c 131 1731 1154 1369 461 206 -51 c

ATOM 4133 N GLN c 132 17.780 -8. .128 -13. .263 1. .00 11. .51 N

ANISOU 4133 N GLN c 132 1920 693 1760 237 - 113 81 N

ATOM 4134 CA GLN c 132 17.743 -9. .114 -14. .366 1. .00 12. .04 C

ANISOU 4134 CA GLN c 132 1566 1075 1931 -5 - 286 ^■136 C

ATOM 4135 C GLN c 132 16.373 -9. .797 -14. .515 1. .00 13. .67 C

ANISOU 4135 C GLN c 132 1419 1850 1921 -16 - 260 19 C

ATOM 4136 O GLN c 132 15.870 -9. .932 -15. .653 1. .00 14. .80 0

ANISOU 4136 O GLN c 132 1317 2280 2024 -144 - 344 -22 0 ATOM 4137 CB GLN C 132 18.854 -10.,157 -14..228 1..00 12..33 C

ANISOU 4137 CB GLN C 132 1377 1213 2091 -58 - 250 74 C

ATOM 4138 CG GLN C 132 20.271 -9. ,578 -14. .292 1. .00 13. .37 C

ANISOU 4138 CG GLN C 132 1155 1865 2059 35 - 393 132 C

ATOM 4139 CD GLN C 132 20.679 -9. ,113 -15. .685 1. .00 14. .62 C

ANISOU 4139 CD GLN C 132 1554 1883 2118 324 - 110 124 C

ATOM 4140 OE1 GLN C 132 19.860 -8. ,582 -16. .447 1. .00 12. .26 O

ANISOU 4140 OE1 GLN C 132 1316 1287 2055 118 -91 -128 O

ATOM 4141 NE2 GLN C 132 21.957 -9. ,325 -16. .037 1. .00 15. .16 N

ANISOU 4141 NE2 GLN C 132 1161 1809 2790 -276 - 403 11 N

ATOM 4142 N LEU C 133 15.778 -10. ,213 -13. .387 1. .00 12. .43 N

ANISOU 4142 N LEU C 133 1451 1312 1959 76 - 332 223 N

ATOM 4143 CA LEU C 133 14.450 -10. ,825 -13. .410 1. .00 12. .52 C

ANISOU 4143 CA LEU C 133 1423 1462 1871 115 -63 222 C

ATOM 4144 C LEU C 133 13.402 -9. ,830 -13. .902 1. .00 12. .80 C

ANISOU 4144 C LEU C 133 1620 1525 1716 149 - 327 67 C

ATOM 4145 O LEU C 133 12.544 -10. ,207 -14. .689 1. .00 12. .50 O

ANISOU 4145 O LEU C 133 1381 1461 1907 93 - 220 -122 O

ATOM 4146 CB LEU C 133 14.058 -11. ,378 -12. .029 1. .00 13. .01 C

ANISOU 4146 CB LEU C 133 1661 1353 1927 -63 - 245 352 C

ATOM 4147 CG LEU C 133 14.841 -12. ,624 -11. .580 1. .00 14. .60 C

ANISOU 4147 CG LEU C 133 2230 1253 2065 226 75 211 C

ATOM 4148 CD1 LEU C 133 14.478 -13. ,001 -10. .155 1. .00 21. .11 C

ANISOU 4148 CD1 LEU c 133 2936 2457 2626 14 596 946 C

ATOM 4149 CD2 LEU c 133 14.613 -13. ,799 -12. .513 1. .00 16. .73 C

ANISOU 4149 CD2 LEU c 133 2658 1415 2284 376 - 224 55 C

ATOM 4150 N ALA c 134 13.478 -8. ,573 -13. .460 1. .00 12. .62 N

ANISOU 4150 N ALA c 134 1351 1463 1981 377 66 -37 N

ATOM 4151 CA ALA c 134 12.536 -7. ,539 -13. .933 1. .00 12. .62 C

ANISOU 4151 CA ALA c 134 1861 1318 1613 389 - 262 -145 C

ATOM 4152 C ALA c 134 12.574 -7. ,372 -15. .465 1. .00 13. .14 C

ANISOU 4152 C ALA c 134 1580 1702 1711 132 71 89 C

ATOM 4153 O ALA c 134 11.531 -7. ,325 -16. .143 1. .00 14. .12 O

ANISOU 4153 O ALA c 134 1716 1785 1860 -68 - 147 288 O

ATOM 4154 CB ALA c 134 12.795 -6. ,204 -13. .243 1. .00 13. .41 C

ANISOU 4154 CB ALA c 134 2166 1444 1485 541 42 -364 C

ATOM 4155 N PHE c 135 13.777 -7. ,307 -16. .026 1. .00 12. .24 N

ANISOU 4155 N PHE c 135 1678 1414 1556 -146 140 0 N

ATOM 4156 CA PHE c 135 13.903 -7. ,195 -17. .477 1. .00 12. .49 C

ANISOU 4156 CA PHE c 135 1223 1936 1586 -54 134 160 C

ATOM 4157 C PHE c 135 13.391 -8. ,462 -18. .170 1. .00 12. .01 C

ANISOU 4157 C PHE c 135 1383 1691 1488 205 54 201 C

ATOM 4158 O PHE c 135 12.655 -8. ,395 -19. .163 1. .00 13. .07 O

ANISOU 4158 O PHE c 135 1444 2041 1478 161 53 -81 O

ATOM 4159 CB PHE c 135 15.366 -6. ,951 -17. .841 1. .00 12. .24 C

ANISOU 4159 CB PHE c 135 1295 1809 1544 -382 106 229 C

ATOM 4160 CG PHE c 135 15.758 -5. ,495 -17. .858 1. .00 12. .29 c

ANISOU 4160 CG PHE c 135 1343 1720 1603 -128 -49 -90 c

ATOM 4161 CD1 PHE c 135 15.584 -4. ,739 -19. .009 1. .00 11. .35 c

ANISOU 4161 CD1 PHE c 135 763 1884 1662 -24 - 167 -35 c

ATOM 4162 CD2 PHE c 135 16.338 -4. ,890 -16. .730 1. .00 12. .76 c

ANISOU 4162 CD2 PHE c 135 1380 1803 1665 23 - 213 -120 c

ATOM 4163 CE1 PHE c 135 15.987 -3. ,404 -19. .060 1. .00 13. .03 c

ANISOU 4163 CE1 PHE c 135 1611 1722 1615 271 - 159 293 c

ATOM 4164 CE2 PHE c 135 16.734 -3. ,553 -16. .772 1. .00 13. .06 c

ANISOU 4164 CE2 PHE c 135 1362 1694 1905 398 - 243 264 c

ATOM 4165 CZ PHE c 135 16.561 -2. ,807 -17. .942 1. .00 13. .57 c

ANISOU 4165 CZ PHE c 135 1364 2118 1673 40 - 118 277 c

ATOM 4166 N LEU c 136 13.762 -9. ,625 -17. .645 1. .00 11. .22 N

ANISOU 4166 N LEU c 136 1244 1446 1570 -76 167 174 N

ATOM 4167 CA LEU c 136 13.350 -10. ,874 -18. .273 1. .00 11. .73 C ANISOU 4167 CA LEU C 136 1566 1316 1573 205 39 167 C

ATOM 4168 C LEU C 136 11.824 -11. .018 -18. .216 1. .00 13. .74 C

ANISOU 4168 C LEU C 136 1625 1917 1677 66 -2 6 C

ATOM 4169 O LEU C 136 11.200 -11. .490 -19. .185 1. .00 12. .95 O

ANISOU 4169 O LEU C 136 1275 1954 1692 -107 -74 216 O

ATOM 4170 CB LEU C 136 14.061 -12. .052 -17. .606 1. .00 13. .31 C

ANISOU 4170 CB LEU C 136 2174 1265 1616 207 14 340 C

ATOM 4171 CG LEU C 136 14.002 -13. .401 -18. .300 1. .00 13. .43 C

ANISOU 4171 CG LEU C 136 2185 1569 1346 504 - 117 181 C

ATOM 4172 CD1 LEU C 136 14.451 -13. .350 -19. .762 1. .00 13. .21 C

ANISOU 4172 CD1 LEU C 136 2064 1425 1527 142 210 298 C

ATOM 4173 CD2 LEU C 136 14.881 -14. .366 -17. .514 1. .00 13. .33 C

ANISOU 4173 CD2 LEU C 136 1812 1818 1432 715 326 438 C

ATOM 4174 N ARG C 137 11.214 -10. .570 -17. .115 1. .00 12. .65 N

ANISOU 4174 N ARG C 137 1532 1652 1621 64 2 178 N

ATOM 4175 CA ARG C 137 9.744 -10. .511 -17. .058 1. .00 13. .27 C

ANISOU 4175 CA ARG C 137 1548 2066 1426 144 30 110 C

ATOM 4176 C ARG C 137 9.162 -9. .672 -18. .191 1. .00 13. .68 C

ANISOU 4176 C ARG C 137 1444 1965 1788 196 - 152 144 C

ATOM 4177 O ARG C 137 8.217 -10. .095 -18. .860 1. .00 15. .54 O

ANISOU 4177 O ARG C 137 1667 2236 2001 335 - 479 62 O

ATOM 4178 CB ARG C 137 9.255 -9. .952 -15. .728 1. .00 11. .19 C

ANISOU 4178 CB ARG C 137 969 1925 1358 37 78 189 C

ATOM 4179 CG ARG c 137 9.390 -10. .961 -14. .606 1. .00 12. .65 C

ANISOU 4179 CG ARG c 137 1565 1648 1591 -241 132 247 c

ATOM 4180 CD ARG c 137 8.955 -10. .347 -13. .283 1. .00 16. .78 c

ANISOU 4180 CD ARG c 137 2192 2384 1799 -11 477 125 c

ATOM 4181 NE ARG c 137 9.337 -11. .193 -12. .158 1. .00 18. .35 N

ANISOU 4181 NE ARG c 137 2828 2212 1930 -231 -46 0 N

ATOM 4182 CZ ARG c 137 10.226 -10. .855 -11. .227 1. .00 15. .57 C

ANISOU 4182 CZ ARG c 137 1742 2462 1709 -330 490 -66 C

ATOM 4183 NH1 ARG c 137 10.808 -9. .653 -11. .249 1. .00 15. .81 N

ANISOU 4183 NH1 ARG c 137 1735 2354 1917 -100 175 -278 N

ATOM 4184 NH2 ARG c 137 10.511 -11. .716 -10. .266 1. .00 15. .47 N

ANISOU 4184 NH2 ARG c 137 1482 2624 1770 -384 281 -81 N

ATOM 4185 N LEU c 138 9.717 -8. .480 -18. .383 1. .00 12. .03 N

ANISOU 4185 N LEU c 138 957 1940 1671 495 51 250 N

ATOM 4186 CA LEU c 138 9.225 -7. .562 -19. .400 1. .00 12. .96 C

ANISOU 4186 CA LEU c 138 1713 1562 1648 183 - 109 219 C

ATOM 4187 C LEU c 138 9.391 -8. .152 -20. .811 1. .00 12. .80 C

ANISOU 4187 C LEU c 138 1268 1762 1832 286 - 128 -43 C

ATOM 4188 O LEU c 138 8.537 -7. .959 -21. .683 1. .00 15. .20 O

ANISOU 4188 O LEU c 138 1984 2106 1682 626 - 291 56 O

ATOM 4189 CB LEU c 138 9.927 -6. .208 -19. .281 1. .00 12. .05 C

ANISOU 4189 CB LEU c 138 1280 1567 1731 221 -37 94 C

ATOM 4190 CG LEU c 138 9.487 -5. .092 -20. .240 1. .00 14. .73 C

ANISOU 4190 CG LEU c 138 1947 1867 1781 269 - 224 197 C

ATOM 4191 CD1 LEU c 138 7.998 -4. .766 -20. .192 1. .00 15. .98 C

ANISOU 4191 CD1 LEU c 138 2029 1936 2105 485 - 325 -258 C

ATOM 4192 CD2 LEU c 138 10.312 -3. .848 -19. .954 1. .00 16. .26 C

ANISOU 4192 CD2 LEU c 138 2391 1606 2179 49 -87 563 C

ATOM 4193 N LEU c 139 10.487 -8. .870 -21. .017 1. .00 12. .83 N

ANISOU 4193 N LEU c 139 1442 1645 1787 346 -96 -86 N

ATOM 4194 CA LEU c 139 10.781 -9. .524 -22. .286 1. .00 12. .62 C

ANISOU 4194 CA LEU c 139 1237 1754 1803 424 -92 -7 C

ATOM 4195 C LEU c 139 9.918 -10. .749 -22. .593 1. .00 13. .04 C

ANISOU 4195 C LEU c 139 1323 1971 1659 197 -36 -22 C

ATOM 4196 O LEU c 139 10.004 -11. .287 -23. .694 1. .00 13. .62 O

ANISOU 4196 O LEU c 139 1771 1733 1670 140 -36 -1 O

ATOM 4197 CB LEU c 139 12.257 -9. .940 -22. .307 1. .00 12. .65 C

ANISOU 4197 CB LEU c 139 1119 1642 2044 248 58 85 C ATOM 4198 CG LEU C 139 13.280 -8..803 -22..404 1..00 9..99 C

ANISOU 4198 CG LEU C 139 887 1588 1320 264 -396 -45 C

ATOM 4199 CD1 LEU c 139 14.649 -9. .232 -21. .861 1. .00 11. .63 C

ANISOU 4199 CD1 LEU c 139 945 1653 1821 403 -346 305 C

ATOM 4200 CD2 LEU c 139 13.384 -8. .282 -23. .833 1. .00 12. .69 C

ANISOU 4200 CD2 LEU c 139 1578 1771 1473 -35 -10 77 C

ATOM 4201 N SER c 140 9.095 -11. .190 -21. .636 1. .00 13. .40 N

ANISOU 4201 N SER c 140 1278 1937 1876 -113 -77 114 N

ATOM 4202 CA SER c 140 8.408 -12. .487 -21. .736 1. .00 13. .22 C

ANISOU 4202 CA SER c 140 1294 1771 1959 81 -254 154 C

ATOM 4203 C SER c 140 6.888 -12. .340 -21. .699 1. .00 14. .07 C

ANISOU 4203 C SER c 140 1314 2146 1883 31 -411 92 C

ATOM 4204 O SER c 140 6.382 -11. .475 -21. .005 1. .00 15. .52 O

ANISOU 4204 O SER c 140 1272 2121 2500 129 -411 -121 O

ATOM 4205 CB SER c 140 8.829 -13. .385 -20. .573 1. .00 13. .12 C

ANISOU 4205 CB SER c 140 1534 1807 1643 -197 -336 128 C

ATOM 4206 OG SER c 140 10.236 -13. .504 -20. .536 1. .00 13. .98 O

ANISOU 4206 OG SER c 140 1638 1947 1724 -194 -579 120 0

ATOM 4207 N SER c 141 6.187 -13. .186 -22. .456 1. .00 13. .47 N

ANISOU 4207 N SER c 141 1367 1689 2061 -407 -521 621 N

ATOM 4208 CA SER c 141 4.723 -13. .210 -22. .439 1. .00 16. .87 C

ANISOU 4208 CA SER c 141 1421 2629 2358 -453 -425 333 C

ATOM 4209 C SER c 141 4.225 -13. .930 -21. .193 1. .00 18. .03 C

ANISOU 4209 C SER c 141 1984 2426 2437 -112 -396 473 C

ATOM 4210 O SER c 141 3.192 -13. .568 -20. .639 1. .00 19. .92 O

ANISOU 4210 O SER c 141 1630 2975 2962 -269 -289 981 O

ATOM 4211 CB SER c 141 4.169 -13. .919 -23. .680 1. .00 21. .67 C

ANISOU 4211 CB SER c 141 2218 3449 2566 -428 -968 202 c

ATOM 4212 OG SER c 141 4.371 -13. .143 -24. .832 1. .00 23. .58 0

ANISOU 4212 OG SER c 141 2380 3524 3055 488 -661 413 0

ATOM 4213 N ARG c 142 4.977 -14. .948 -20. .770 1. .00 16. .81 N

ANISOU 4213 N ARG c 142 1594 2332 2461 -447 -701 752 N

ATOM 4214 CA ARG c 142 4.598 -15. .833 -19. .662 1. .00 16. .97 C

ANISOU 4214 CA ARG c 142 1378 2638 2429 -30 -365 718 C

ATOM 4215 C ARG c 142 5.821 -16. .283 -18. .868 1. .00 18. .08 C

ANISOU 4215 C ARG c 142 1711 3173 1985 68 -377 997 C

ATOM 4216 O ARG c 142 6.968 -16. .193 -19. .336 1. .00 19. .32 O

ANISOU 4216 O ARG c 142 1957 2892 2492 -147 38 1138 O

ATOM 4217 CB ARG c 142 3.894 -17. .089 -20. .191 1. .00 20. .84 c

ANISOU 4217 CB ARG c 142 1874 3230 2812 -240 -1018 323 c

ATOM 4218 CG ARG c 142 2.461 -16. .867 -20. .637 1. .00 23. .40 c

ANISOU 4218 CG ARG c 142 2131 3250 3509 -194 -1481 60 c

ATOM 4219 CD ARG c 142 1.891 -18. .151 -21. .236 1. .00 30. .44 c

ANISOU 4219 CD ARG c 142 2996 4170 4400 -1001 -1723 -636 c

ATOM 4220 NE ARG c 142 0.690 -17. .905 -22. .029 1. .00 32. .79 N

ANISOU 4220 NE ARG c 142 3160 4119 5180 -1361 -1909 279 N

ATOM 4221 CZ ARG c 142 0.690 -17. .382 -23. .254 1. .00 38. .21 C

ANISOU 4221 CZ ARG c 142 4373 4911 5235 -1389 -1559 611 C

ATOM 4222 NH1 ARG c 142 1.838 -17. .033 -23. .841 1. .00 33. .73 N

ANISOU 4222 NH1 ARG c 142 3907 3752 5156 -1745 -2376 869 N

ATOM 4223 NH2 ARG c 142 -0.464 -17. .201 -23. .892 1. .00 42. .29 N

ANISOU 4223 NH2 ARG c 142 3931 5246 6891 -438 -1321 337 N

ATOM 4224 N ALA c 143 5.550 -16. .783 -17. .672 1. .00 17. .76 N

ANISOU 4224 N ALA c 143 1576 2976 2195 676 213 1049 N

ATOM 4225 CA ALA c 143 6.535 -17. .488 -16. .865 1. .00 14. .77 C

ANISOU 4225 CA ALA c 143 1596 2578 1436 47 -32 878 C

ATOM 4226 C ALA c 143 5.845 -18. .709 -16. .247 1. .00 15. .50 C

ANISOU 4226 C ALA c 143 1588 2140 2162 289 219 756 C

ATOM 4227 O ALA c 143 4.620 -18. .687 -15. .994 1. .00 18. .45 O

ANISOU 4227 O ALA c 143 1333 2644 3030 125 -108 1032 O

ATOM 4228 CB ALA c 143 7.109 -16. .578 -15. .784 1. .00 16. .10 C ANISOU 4228 CB ALA C 143 1756 1903 2459 -373 251 611 C

ATOM 4229 N SER C 144 6.618 -19. ,765 -16. .005 1. .00 13. , 70 N

ANISOU 4229 N SER C 144 1377 2200 1629 239 -9 839 N

ATOM 4230 CA SER C 144 6.118 -20. ,968 -15. .342 1. .00 12. , 99 C

ANISOU 4230 CA SER C 144 1153 2235 1546 55 132 663 C

ATOM 4231 C SER C 144 7.205 -21. ,557 -14. .470 1. .00 13. , 34 C

ANISOU 4231 C SER C 144 1225 2221 1622 -182 -10 757 C

ATOM 4232 O SER C 144 8.406 -21. ,312 -14. .679 1. .00 14. , 62 O

ANISOU 4232 O SER C 144 1281 2574 1699 -219 193 733 O

ATOM 4233 CB SER C 144 5.639 -22. ,042 -16. .332 1. .00 14. , 42 C

ANISOU 4233 CB SER C 144 1556 2054 1866 308 - 185 550 C

ATOM 4234 OG SER C 144 6.735 -22. ,642 -17. .022 1. .00 19. , 18 O

ANISOU 4234 OG SER C 144 2438 2621 2228 188 303 0 O

ATOM 4235 N GLN C 145 6.775 -22. ,339 -13. .489 1. .00 12. , 60 N

ANISOU 4235 N GLN C 145 1486 1773 1528 -135 45 553 N

ATOM 4236 CA GLN C 145 7.694 -23. ,026 -12. .626 1. .00 11. , 66 C

ANISOU 4236 CA GLN C 145 1129 1666 1633 -43 70 343 C

ATOM 4237 C GLN C 145 7.058 -24. ,242 -12. .015 1. .00 12. , 80 C

ANISOU 4237 C GLN C 145 1317 1636 1910 -113 -41 371 C

ATOM 4238 O GLN C 145 5.883 -24. ,201 -11. .617 1. .00 12. , 70 O

ANISOU 4238 O GLN C 145 1330 1536 1960 112 25 351 O

ATOM 4239 CB GLN C 145 8.210 -22. ,110 -11. .527 1. .00 11. , 68 C

ANISOU 4239 CB GLN C 145 1223 1600 1616 113 123 231 C

ATOM 4240 CG GLN c 145 9.339 -22. ,753 -10. .719 1. .00 11. , 60 c

ANISOU 4240 CG GLN c 145 1274 1652 1480 -66 -43 165 c

ATOM 4241 CD GLN c 145 9.883 -21. ,822 -9. .675 1. .00 12. ,19 c

ANISOU 4241 CD GLN c 145 1076 1819 1737 -459 117 131 c

ATOM 4242 OE1 GLN c 145 9.407 -20. ,687 -9. .538 1. .00 13. , 08 0

ANISOU 4242 OE1 GLN c 145 1532 1768 1671 -390 - 164 -78 0

ATOM 4243 NE2 GLN c 145 10.877 -22. ,290 -8. .916 1. .00 14. , 33 N

ANISOU 4243 NE2 GLN c 145 1519 2025 1900 -257 - 173 105 N

ATOM 4244 N GLN c 146 7.851 -25. ,315 -11. .931 1. .00 11. , 54 N

ANISOU 4244 N GLN c 146 1156 1348 1879 -294 - 103 79 N

ATOM 4245 CA GLN c 146 7.451 -26. ,534 -11. .254 1. .00 11. ,89 C

ANISOU 4245 CA GLN c 146 1512 1543 1460 -288 -37 208 C

ATOM 4246 C GLN c 146 8.195 -26. ,683 -9. .945 1. .00 14. ,09 C

ANISOU 4246 C GLN c 146 1636 2009 1709 -568 - 272 161 C

ATOM 4247 O GLN c 146 9.343 -26. ,221 -9. .802 1. .00 13. , 92 O

ANISOU 4247 O GLN c 146 1348 2331 1608 -375 -86 359 O

ATOM 4248 CB GLN c 146 7.710 -27. ,768 -12. .139 1. .00 13. , 62 C

ANISOU 4248 CB GLN c 146 1619 1802 1753 -489 - 255 -159 C

ATOM 4249 CG GLN c 146 6.808 -27. ,798 -13. .360 1. .00 17. , 00 C

ANISOU 4249 CG GLN c 146 2563 2404 1490 -306 - 351 -397 C

ATOM 4250 CD GLN c 146 7.016 -29. ,021 -14. .220 1. .00 20. , 34 C

ANISOU 4250 CD GLN c 146 2889 2486 2353 -57 -42 -643 c

ATOM 4251 OE1 GLN c 146 7.581 -30. ,030 -13. .789 1. .00 21. ,89 0

ANISOU 4251 OE1 GLN c 146 2612 2449 3253 322 641 -802 0

ATOM 4252 NE2 GLN c 146 6.549 -28. ,940 -15. .447 1. .00 27. , 14 N

ANISOU 4252 NE2 GLN c 146 3945 3958 2407 -604 - 295 - 1102 N

ATOM 4253 N ILE c 147 7.537 -27. ,348 -8. .995 1. .00 13. , 42 N

ANISOU 4253 N ILE c 147 1503 2094 1500 9 - 159 272 N

ATOM 4254 CA ILE c 147 8.144 -27. ,643 -7. .706 1. .00 12. ,01 C

ANISOU 4254 CA ILE c 147 1333 2003 1227 -75 86 112 C

ATOM 4255 C ILE c 147 7.652 -29. ,014 -7. .233 1. .00 13. , 93 C

ANISOU 4255 C ILE c 147 1486 2082 1723 -92 45 243 C

ATOM 4256 O ILE c 147 6.462 -29. ,380 -7. .400 1. .00 12. , 14 O

ANISOU 4256 O ILE c 147 1361 1693 1555 -5 -13 321 O

ATOM 4257 CB ILE c 147 7.898 -26. ,482 -6. .710 1. .00 14. ,19 C

ANISOU 4257 CB ILE c 147 1508 2426 1456 73 22 -207 C

ATOM 4258 CGI ILE c 147 8.636 -26. ,695 -5. .378 1. .00 15. , 96 C

ANISOU 4258 CGI ILE c 147 2356 2363 1344 199 - 121 -403 C ATOM 4259 CG2 ILE C 147 6.411 -26..256 -6..496 1..00 16..60 C

ANISOU 4259 CG2 ILE C 147 1524 3028 1755 -2 358 -172 C

ATOM 4260 CD1 ILE C 147 8.697 -25. .449 -4. .508 1. .00 18. .69 C

ANISOU 4260 CD1 ILE C 147 2530 2656 1913 -235 19 -766 C

ATOM 4261 N THR C 148 8.584 -29. .803 -6. .702 1. .00 13. .90 N

ANISOU 4261 N THR C 148 1844 1834 1602 -72 -2 183 N

ATOM 4262 CA THR C 148 8.279 -31. .168 -6. .293 1. .00 13. .55 C

ANISOU 4262 CA THR C 148 1595 1909 1643 -156 268 262 C

ATOM 4263 C THR C 148 8.347 -31. .287 -4. .782 1. .00 14. .76 C

ANISOU 4263 C THR C 148 1538 2404 1665 -571 32 142 C

ATOM 4264 O THR C 148 9.369 -30. .959 -4. .172 1. .00 14. .60 O

ANISOU 4264 O THR C 148 1417 2216 1913 -533 -165 558 O

ATOM 4265 CB THR C 148 9.262 -32. .158 -6. .959 1. .00 14. .28 C

ANISOU 4265 CB THR C 148 1835 1984 1607 -59 204 49 C

ATOM 4266 OG1 THR C 148 9.114 -32. .063 -8. .373 1. .00 16. .89 O

ANISOU 4266 OG1 THR C 148 1892 2763 1759 53 14 198 0

ATOM 4267 CG2 THR C 148 9.011 -33. .615 -6. .510 1. .00 16. .59 c

ANISOU 4267 CG2 THR c 148 1340 2116 2845 -349 20 66 c

ATOM 4268 N TYR c 149 7.250 -31. .751 -4. .185 1. .00 13. .80 N

ANISOU 4268 N TYR c 149 1410 2267 1566 -114 229 298 N

ATOM 4269 CA TYR c 149 7.196 -32. .000 -2. .763 1. .00 13. .70 C

ANISOU 4269 CA TYR c 149 1350 2308 1545 -7 -27 272 C

ATOM 4270 C TYR c 149 7.394 -33. .498 -2. .526 1. .00 14. .47 C

ANISOU 4270 C TYR c 149 1507 2261 1727 -101 363 450 C

ATOM 4271 O TYR c 149 6.578 -34. .312 -2. .963 1. .00 15. .58 O

ANISOU 4271 O TYR c 149 1523 2459 1937 -37 149 387 O

ATOM 4272 CB TYR c 149 5.851 -31. .527 -2. .208 1. .00 13. .74 c

ANISOU 4272 CB TYR c 149 1834 2085 1301 155 193 71 c

ATOM 4273 CG TYR c 149 5.674 -31. .626 -0. .710 1. .00 13. .36 c

ANISOU 4273 CG TYR c 149 1649 2002 1425 11 458 212 c

ATOM 4274 CD1 TYR c 149 6.167 -30. .632 0. .146 1. .00 15. .71 c

ANISOU 4274 CD1 TYR c 149 2274 2264 1427 -112 328 74 c

ATOM 4275 CD2 TYR c 149 4.964 -32. .675 -0. .152 1. .00 14. .92 c

ANISOU 4275 CD2 TYR c 149 2102 2053 1514 -232 61 460 c

ATOM 4276 CE1 TYR c 149 5.970 -30. .701 1. .518 1. .00 15. .00 c

ANISOU 4276 CE1 TYR c 149 1684 2454 1561 -197 625 389 c

ATOM 4277 CE2 TYR c 149 4.747 -32. .752 1. .220 1. .00 16. .47 c

ANISOU 4277 CE2 TYR c 149 2633 2064 1560 -285 350 175 c

ATOM 4278 CZ TYR c 149 5.255 -31. .775 2. .052 1. .00 16. .65 c

ANISOU 4278 CZ TYR c 149 2336 2245 1745 -570 -10 392 c

ATOM 4279 OH TYR c 149 5.042 -31. .865 3. .411 1. .00 18. .96 0

ANISOU 4279 OH TYR c 149 2433 3061 1709 -465 -283 737 0

ATOM 4280 N HIS c 150 8.498 -33. .860 -1. .874 1. .00 16. .12 N

ANISOU 4280 N HIS c 150 1590 2479 2056 -177 202 683 N

ATOM 4281 CA HIS c 150 8.732 -35. .252 -1. .452 1. .00 16. .81 c

ANISOU 4281 CA HIS c 150 1588 2638 2157 167 264 644 c

ATOM 4282 C HIS c 150 8.121 -35. .459 -0. .106 1. .00 18. .56 c

ANISOU 4282 C HIS c 150 2011 2827 2213 -261 285 858 c

ATOM 4283 O HIS c 150 8.358 -34. .662 0. .809 1. .00 18. .68 0

ANISOU 4283 O HIS c 150 1664 2994 2439 -98 145 679 0

ATOM 4284 CB HIS c 150 10.218 -35. .564 -1. .386 1. .00 17. .34 c

ANISOU 4284 CB HIS c 150 1703 2618 2264 642 475 550 c

ATOM 4285 CG HIS c 150 10.914 -35. .477 -2. .723 1. .00 18. .61 c

ANISOU 4285 CG HIS c 150 2185 2690 2196 839 522 630 c

ATOM 4286 ND1 HIS c 150 10.954 -36. .507 -3. .586 1. .00 22. .73 N

ANISOU 4286 ND1 HIS c 150 2671 3048 2915 965 733 164 N

ATOM 4287 CD2 HIS c 150 11.573 -34. .417 -3. .343 1. .00 24. .05 C

ANISOU 4287 CD2 HIS c 150 2575 3376 3185 455 1008 845 C

ATOM 4288 CE1 HIS c 150 11.627 -36. .137 -4. .696 1. .00 22. .62 C

ANISOU 4288 CE1 HIS c 150 2307 3818 2468 301 145 14 C

ATOM 4289 NE2 HIS c 150 11.996 -34. .855 -4. .551 1. .00 24. .51 N ANISOU 4289 NE2 HIS C 150 2556 3565 3192 630 685 497 N

ATOM 4290 N CYS C 151 7.342 -36. .532 0. .037 1. .00 17. .82 N

ANISOU 4290 N CYS C 151 1519 2540 2710 11 -353 826 N

ATOM 4291 CA CYS C 151 6.500 -36. .712 1. .218 1. .00 18. .68 C

ANISOU 4291 CA CYS C 151 1702 2806 2587 -11 -407 1093 C

ATOM 4292 C CYS C 151 6.633 -38. .090 1. .825 1. .00 18. .12 C

ANISOU 4292 C CYS C 151 1696 2359 2830 192 -201 668 C

ATOM 4293 O CYS C 151 6.631 -39. .098 1. .113 1. .00 20. .37 O

ANISOU 4293 O CYS C 151 3106 1670 2962 0 -386 1067 O

ATOM 4294 CB CYS C 151 5.026 -36. .510 0. .840 1. .00 16. .40 C

ANISOU 4294 CB CYS C 151 1456 2330 2444 -142 -80 604 C

ATOM 4295 SG CYS C 151 4.553 -37. .649 -0. .483 1. .00 19. .44 S

ANISOU 4295 SG CYS C 151 1931 2993 2460 -245 -59 562 S

ATOM 4296 N LYS C 152 6.739 -38. .133 3. .146 1. .00 18. .89 N

ANISOU 4296 N LYS C 152 1964 2357 2853 -249 -196 860 N

ATOM 4297 CA LYS C 152 6.587 -39. .388 3. .890 1. .00 19. .15 C

ANISOU 4297 CA LYS C 152 2049 2658 2568 181 -300 1152 C

ATOM 4298 C LYS C 152 5.582 -39. .079 4. .978 1. .00 21. .56 C

ANISOU 4298 C LYS C 152 2100 3255 2837 -246 77 1239 C

ATOM 4299 O LYS C 152 5.816 -38. .171 5. .793 1. .00 21. .56 O

ANISOU 4299 O LYS C 152 2412 3241 2537 -862 134 1549 O

ATOM 4300 CB LYS C 152 7.929 -39. .860 4. .480 1. .00 20. .68 C

ANISOU 4300 CB LYS c 152 1757 3087 3012 3 -335 1007 C

ATOM 4301 CG LYS c 152 7.837 -41. .124 5. .321 1. .00 25. .40 c

ANISOU 4301 CG LYS c 152 2326 2990 4332 64 -1228 1389 c

ATOM 4302 CD LYS c 152 9.155 -41. .419 6. .026 1. .00 30. .39 c

ANISOU 4302 CD LYS c 152 2576 3798 5171 1303 -951 2507 c

ATOM 4303 CE LYS c 152 9.030 -42. .562 7. .009 1. .00 39. .27 c

ANISOU 4303 CE LYS c 152 4922 4350 5648 1003 -1237 3019 c

ATOM 4304 NZ LYS c 152 10.382 -43. .095 7. .341 1. .00 48. .62 N

ANISOU 4304 NZ LYS c 152 4385 7367 6721 623 -1990 2166 N

ATOM 4305 N ASN c 153 4.456 -39. .804 4. .973 1. .00 21. .44 N

ANISOU 4305 N ASN c 153 1939 3479 2726 -209 207 1296 N

ATOM 4306 CA ASN c 153 3.318 -39. .523 5. .881 1. .00 22. .49 C

ANISOU 4306 CA ASN c 153 2434 3782 2327 355 162 1046 C

ATOM 4307 C ASN c 153 2.930 -38. .042 5. .915 1. .00 22. .74 C

ANISOU 4307 C ASN c 153 2771 3488 2381 -317 237 896 C

ATOM 4308 O ASN c 153 2.768 -37. .451 6. .987 1. .00 22. .06 O

ANISOU 4308 O ASN c 153 2209 4162 2009 -419 79 824 O

ATOM 4309 CB ASN c 153 3.597 -40. .034 7. .309 1. .00 25. .55 C

ANISOU 4309 CB ASN c 153 2687 4330 2691 -200 -567 1339 C

ATOM 4310 CG ASN c 153 3.995 -41. .495 7. .337 1. .00 32. .06 C

ANISOU 4310 CG ASN c 153 4332 4260 3588 -141 -275 1869 C

ATOM 4311 OD1 ASN c 153 4.949 -41. .882 8. .026 1. .00 39. .49 O

ANISOU 4311 OD1 ASN c 153 4974 6011 4017 1338 74 1967 0

ATOM 4312 ND2 ASN c 153 3.284 -42. .313 6. .579 1. .00 27. .51 N

ANISOU 4312 ND2 ASN c 153 3001 3783 3667 -276 652 1637 N

ATOM 4313 N SER c 154 2.792 -37. .438 4. .740 1. .00 21. .98 N

ANISOU 4313 N SER c 154 2121 3548 2683 281 -354 1006 N

ATOM 4314 CA SER c 154 2.498 -36. .016 4. .665 1. .00 20. .31 C

ANISOU 4314 CA SER c 154 2238 3268 2209 -187 -259 684 C

ATOM 4315 C SER c 154 1.693 -35. .735 3. .414 1. .00 17. .51 C

ANISOU 4315 C SER c 154 1925 2689 2038 0 -53 534 C

ATOM 4316 O SER c 154 2.209 -35. .837 2. .313 1. .00 20. .93 O

ANISOU 4316 O SER c 154 2861 3473 1616 -7 -370 134 O

ATOM 4317 CB SER c 154 3.789 -35. .187 4. .653 1. .00 19. .81 C

ANISOU 4317 CB SER c 154 2392 2968 2165 -235 -302 547 C

ATOM 4318 OG SER c 154 3.491 -33. .807 4. .522 1. .00 20. .15 O

ANISOU 4318 OG SER c 154 2723 3118 1811 3 -128 397 O

ATOM 4319 N ILE c 155 0.428 -35. .375 3. .591 1. .00 17. .67 N

ANISOU 4319 N ILE c 155 1781 3169 1762 -263 60 812 N ATOM 4320 CA ILE C 155 -0.419 -34.,993 2..467 1..00 15..85 C

ANISOU 4320 CA ILE C 155 1563 3029 1429 -156 370 837 C

ATOM 4321 C ILE C 155 0.079 -33. ,678 1. .846 1. .00 15. .29 C

ANISOU 4321 C ILE C 155 1705 2785 1320 -328 254 455 C

ATOM 4322 O ILE C 155 0.465 -32. ,753 2. .573 1. .00 16. .77 O

ANISOU 4322 O ILE C 155 1796 3051 1523 -375 464 188 O

ATOM 4323 CB ILE C 155 -1.892 -34. ,909 2. .916 1. .00 16. .45 C

ANISOU 4323 CB ILE C 155 1422 3178 1648 -487 213 855 C

ATOM 4324 CGI ILE C 155 -2.400 -36. ,334 3. .161 1. .00 21. .89 C

ANISOU 4324 CGI ILE C 155 1929 3734 2652 -1134 605 750 C

ATOM 4325 CG2 ILE C 155 -2.743 -34. ,174 1. .884 1. .00 16. .37 C

ANISOU 4325 CG2 ILE C 155 1320 3516 1381 -185 284 470 C

ATOM 4326 CD1 ILE C 155 -3.488 -36. ,407 4. .186 1. .00 23. .11 C

ANISOU 4326 CD1 ILE C 155 1622 4460 2696 -1088 423 666 C

ATOM 4327 N ALA C 156 0.095 -33. ,614 0. .509 1. .00 13. .71 N

ANISOU 4327 N ALA C 156 1375 2566 1265 -566 513 595 N

ATOM 4328 CA ALA C 156 0.554 -32. ,411 -0. .214 1. .00 13. .76 C

ANISOU 4328 CA ALA C 156 1748 1989 1491 -200 363 453 C

ATOM 4329 C ALA C 156 -0.573 -31. ,672 -0. .894 1. .00 12. .01 C

ANISOU 4329 C ALA C 156 1232 1972 1357 -191 398 ^■158 C

ATOM 4330 O ALA C 156 -0.538 -30. ,449 -1. .013 1. .00 12. .24 O

ANISOU 4330 O ALA c 156 1094 2005 1550 -534 424 ^■247 O

ATOM 4331 CB ALA c 156 1.583 -32. ,782 -1. .274 1. .00 14. .10 C

ANISOU 4331 CB ALA c 156 1665 2123 1567 12 219 142 C

ATOM 4332 N TYR c 157 -1.533 -32. ,424 -1. .421 1. .00 11. .88 N

ANISOU 4332 N TYR c 157 1387 1876 1251 -152 131 -32 N

ATOM 4333 CA TYR c 157 -2.595 -31. ,827 -2. .214 1. .00 13. .22 C

ANISOU 4333 CA TYR c 157 1464 2244 1314 -148 26 4 C

ATOM 4334 C TYR c 157 -3.917 -32. ,452 -1. .788 1. .00 13. .12 C

ANISOU 4334 C TYR c 157 1476 1859 1649 -114 34 0 C

ATOM 4335 O TYR c 157 -4.598 -31. ,912 -0. .893 1. .00 14. .60 O

ANISOU 4335 O TYR c 157 1797 2469 1281 -159 343 196 O

ATOM 4336 CB TYR c 157 -2.330 -32. ,013 -3. .712 1. .00 13. .01 C

ANISOU 4336 CB TYR c 157 1375 2240 1327 -50 131 276 C

ATOM 4337 CG TYR c 157 -3.397 -31. ,426 -4. .606 1. .00 13. .03 c

ANISOU 4337 CG TYR c 157 1596 2217 1137 -65 -27 139 c

ATOM 4338 CD1 TYR c 157 -3.698 -30. ,059 -4. .564 1. .00 13. .22 c

ANISOU 4338 CD1 TYR c 157 1412 2269 1339 54 453 446 c

ATOM 4339 CD2 TYR c 157 -4.106 -32. ,241 -5. .502 1. .00 13. .49 c

ANISOU 4339 CD2 TYR c 157 1451 2285 1387 -118 -102 88 c

ATOM 4340 CE1 TYR c 157 -4.664 -29. ,513 -5. .415 1. .00 14. .06 c

ANISOU 4340 CE1 TYR c 157 1145 2605 1589 8 244 165 c

ATOM 4341 CE2 TYR c 157 -5.075 -31. ,701 -6. .344 1. .00 14. .93 c

ANISOU 4341 CE2 TYR c 157 1131 2826 1714 -110 -219 32 c

ATOM 4342 CZ TYR c 157 -5.345 -30. ,339 -6. .296 1. .00 16. .80 c

ANISOU 4342 CZ TYR c 157 1934 2804 1643 133 -236 117 c

ATOM 4343 OH TYR c 157 -6.318 -29. ,777 -7. .102 1. .00 17. .40 0

ANISOU 4343 OH TYR c 157 2374 2064 2171 446 -387 18 0

ATOM 4344 N MET c 158 -4.262 -33. ,586 -2. .396 1. .00 13. .05 N

ANISOU 4344 N MET c 158 1457 1787 1712 -314 375 11 N

ATOM 4345 CA MET c 158 -5.472 -34. ,321 -2. .016 1. .00 12. .71 C

ANISOU 4345 CA MET c 158 1457 1824 1548 -491 238 ^■195 c

ATOM 4346 C MET c 158 -5.225 -35. ,288 -0. .864 1. .00 14. .53 c

ANISOU 4346 C MET c 158 1804 1841 1875 -432 522 -5 c

ATOM 4347 O MET c 158 -4.168 -35. ,919 -0. .781 1. .00 17. .55 0

ANISOU 4347 O MET c 158 2036 2522 2109 -150 521 ^■210 0

ATOM 4348 CB MET c 158 -6.052 -35. ,098 -3. .206 1. .00 13. .37 c

ANISOU 4348 CB MET c 158 1565 1749 1766 -729 235 ^■218 c

ATOM 4349 CG MET c 158 -7.338 -35. ,783 -2. .794 1. .00 19. .52 c

ANISOU 4349 CG MET c 158 2182 2690 2544 -1560 386 ^■437 c

ATOM 4350 SD MET c 158 -8.080 -36. ,592 -4. .197 1. .00 41. .13 s ANISOU 4350 SD MET C 158 4618 6109 4900 -706 105 608 S

ATOM 4351 CE MET C 158 -8.787 -35 174 -4.969 1 00 28.26 C

ANISOU 4351 CE MET C 158 2016 4359 4362 -1723 -356 -1320 C

ATOM 4352 N ASP C 159 -6.210 -35 389 0.025 1 00 12.97 N

ANISOU 4352 N ASP C 159 1531 1757 1638 -187 357 -76 N

ATOM 4353 CA ASP C 159 -6.234 -36 344 1.127 1 00 15.33 C

ANISOU 4353 CA ASP C 159 1879 1825 2118 -354 389 205 C

ATOM 4354 C ASP C 159 -7.162 -37 481 0.664 1 00 15.93 C

ANISOU 4354 C ASP C 159 1821 1990 2242 -429 615 -35 C

ATOM 4355 O ASP C 159 -8.325 -37 230 0.363 1 00 18.26 O

ANISOU 4355 O ASP C 159 1651 2640 2646 -658 739 -17 O

ATOM 4356 CB ASP C 159 -6.790 -35 635 2.371 1 00 16.50 C

ANISOU 4356 CB ASP C 159 2106 2373 1789 -336 219 124 C

ATOM 4357 CG ASP C 159 -6.940 -36 553 3.596 1 00 24.28 C

ANISOU 4357 CG ASP C 159 3607 3402 2213 -142 844 696 C

ATOM 4358 OD1 ASP C 159 -6.780 -37 775 3.506 1 00 28.08 O

ANISOU 4358 OD1 ASP C 159 4622 3704 2342 126 755 779 O

ATOM 4359 OD2 ASP C 159 -7.237 -36 026 4.684 1 00 30.82 O

ANISOU 4359 OD2 ASP C 159 4825 4357 2527 -674 1149 419 O

ATOM 4360 N GLN C 160 -6.643 -38 700 0.548 1 00 15.16 N

ANISOU 4360 N GLN C 160 1435 1941 2381 -556 540 2 N

ATOM 4361 CA GLN C 160 -7.415 -39 813 -0.010 1 00 17.56 C

ANISOU 4361 CA GLN C 160 2104 2236 2332 -784 1152 -699 C

ATOM 4362 C GLN C 160 -8.685 -40 084 0.807 1 00 18.61 C

ANISOU 4362 C GLN c 160 2290 2530 2250 -807 1231 -597 C

ATOM 4363 O GLN c 160 -9.743 -40 422 0.252 1 00 24.30 O

ANISOU 4363 O GLN c 160 2623 2572 4034 -1134 805 -693 O

ATOM 4364 CB GLN c 160 -6.558 -41 082 -0.105 1 00 20.03 C

ANISOU 4364 CB GLN c 160 2537 2530 2543 -414 1093 -1114 C

ATOM 4365 CG GLN c 160 -7.248 -42 269 -0.770 1 00 24.06 C

ANISOU 4365 CG GLN c 160 2331 3051 3756 -866 1187 -1395 C

ATOM 4366 N ALA c 161 -8.567 -39 931 2.117 1 00 19.46 N

ANISOU 4366 N ALA c 161 2380 2901 2110 -843 1005 167 N

ATOM 4367 CA ALA c 161 -9.696 -40 161 3.030 1 00 19.85 C

ANISOU 4367 CA ALA c 161 1947 3394 2198 -756 911 -219 C

ATOM 4368 C ALA c 161 -10.887 -39 182 2.862 1 00 21.17 C

ANISOU 4368 C ALA c 161 2345 2865 2830 -920 254 209 C

ATOM 4369 O ALA c 161 -12.048 -39 581 3.000 1 00 22.99 O

ANISOU 4369 O ALA c 161 2057 3700 2975 -422 649 81 O

ATOM 4370 CB ALA c 161 -9.201 -40 165 4.473 1 00 23.31 C

ANISOU 4370 CB ALA c 161 2766 3779 2311 -760 489 -176 C

ATOM 4371 N SER c 162 -10.608 -37 909 2.597 1 00 17.24 N

ANISOU 4371 N SER c 162 1183 2780 2588 -774 477 41 N

ATOM 4372 CA SER c 162 -11.678 -36 915 2.429 1 00 18.86 C

ANISOU 4372 CA SER c 162 2027 2317 2821 -755 601 136 C

ATOM 4373 C SER c 162 -12.031 -36 681 0.957 1 00 21.62 C

ANISOU 4373 C SER c 162 1700 3647 2865 -578 443 -258 C

ATOM 4374 O SER c 162 -13.138 -36 251 0.635 1 00 21.64 O

ANISOU 4374 O SER c 162 1699 3469 3051 -778 588 210 O

ATOM 4375 CB SER c 162 -11.266 -35 592 3.069 1 00 18.92 C

ANISOU 4375 CB SER c 162 1434 2658 3095 -822 337 -159 C

ATOM 4376 OG SER c 162 -10.202 -35 006 2.330 1 00 19.20 O

ANISOU 4376 OG SER c 162 1415 3001 2876 -285 776 -172 O

ATOM 4377 N GLY c 163 -11.078 -36 939 0.065 1 00 20.28 N

ANISOU 4377 N GLY c 163 2081 3122 2500 -603 466 -561 N

ATOM 4378 CA GLY c 163 -11.257 -36 625 -1.344 1 00 19.31 C

ANISOU 4378 CA GLY c 163 1533 3221 2581 -429 677 -381 C

ATOM 4379 C GLY c 163 -11.191 -35 133 -1.611 1 00 20.52 C

ANISOU 4379 C GLY c 163 1997 3062 2735 -205 624 -776 C

ATOM 4380 O GLY c 163 -11.497 -34 689 -2.723 1 00 25.03 O

ANISOU 4380 O GLY c 163 2793 3558 3156 -702 10 -760 O ATOM 4381 N ASN C 164 -10.773 -34.,359 -0..610 1..00 22..13 N

ANISOU 4381 N ASN C 164 2425 3175 2805 -905 482 -573 N

ATOM 4382 CA ASN C 164 -10.690 -32. ,895 -0. .721 1. .00 19. .99 C

ANISOU 4382 CA ASN C 164 1762 3054 2780 -341 816 -758 C

ATOM 4383 C ASN C 164 -9.252 -32. ,370 -0. .596 1. .00 16. .97 C

ANISOU 4383 C ASN C 164 1937 2232 2278 -330 398 -562 C

ATOM 4384 O ASN C 164 -8.334 -33. ,100 -0. .209 1. .00 16. .29 O

ANISOU 4384 O ASN C 164 1843 2316 2029 -355 454 -128 O

ATOM 4385 CB ASN C 164 -11.678 -32. ,171 0. .236 1. .00 21. .39 C

ANISOU 4385 CB ASN C 164 1728 3478 2919 -590 1056 -970 C

ATOM 4386 CG ASN C 164 -11.209 -32. ,118 1. .699 1. .00 25. .51 C

ANISOU 4386 CG ASN C 164 2697 4047 2949 -222 1167 -452 C

ATOM 4387 OD1 ASN C 164 -10.024 -31. ,874 1. .998 1. .00 26. .00 O

ANISOU 4387 OD1 ASN C 164 3002 3710 3166 -712 1385 -496 O

ATOM 4388 ND2 ASN C 164 -12.173 -32. ,284 2. .634 1. .00 24. .03 N

ANISOU 4388 ND2 ASN C 164 1737 3305 4088 -916 1170 -880 N

ATOM 4389 N VAL C 165 -9.066 -31. ,099 -0. .928 1. .00 16. .66 N

ANISOU 4389 N VAL c 165 2093 2408 1828 -376 329 -244 N

ATOM 4390 CA VAL c 165 -7.721 -30. ,520 -0. .971 1. .00 16. .23 C

ANISOU 4390 CA VAL c 165 1956 2542 1669 -222 169 -230 C

ATOM 4391 C VAL c 165 -7.534 -29. ,435 0. .088 1. .00 15. .58 C

ANISOU 4391 C VAL c 165 1944 2784 1191 -244 228 -118 C

ATOM 4392 O VAL c 165 -6.698 -28. ,541 -0. .067 1. .00 18. .29 O

ANISOU 4392 O VAL c 165 1880 3079 1989 -221 274 151 O

ATOM 4393 CB VAL c 165 -7.371 -30. ,002 -2. .385 1. .00 15. .83 C

ANISOU 4393 CB VAL c 165 2048 2322 1643 68 283 -351 C

ATOM 4394 CGI VAL c 165 -7.336 -31. ,165 -3. .364 1. .00 15. .94 C

ANISOU 4394 CGI VAL c 165 1786 2459 1812 132 407 -517 C

ATOM 4395 CG2 VAL c 165 -8.395 -28. ,968 -2. .840 1. .00 16. .50 C

ANISOU 4395 CG2 VAL c 165 1925 2773 1569 -94 -561 -309 C

ATOM 4396 N LYS c 166 -8.284 -29. ,542 1. .187 1. .00 16. .31 N

ANISOU 4396 N LYS c 166 1588 3045 1564 162 452 -222 N

ATOM 4397 CA LYS c 166 -8.196 -28. ,562 2. .274 1. .00 16. .46 C

ANISOU 4397 CA LYS c 166 1600 2913 1739 -29 512 -230 C

ATOM 4398 C LYS c 166 -6.866 -28. ,624 3. .022 1. .00 14. .84 C

ANISOU 4398 C LYS c 166 1839 2289 1511 -182 359 -245 C

ATOM 4399 O LYS c 166 -6.437 -27. ,631 3. .634 1. .00 19. .11 O

ANISOU 4399 O LYS c 166 2371 2923 1964 -300 203 -730 O

ATOM 4400 CB LYS c 166 -9.397 -28. ,706 3. .235 1. .00 18. .84 C

ANISOU 4400 CB LYS c 166 1806 3281 2069 -562 726 -395 C

ATOM 4401 CG LYS c 166 -10.754 -28. ,581 2. .536 1. .00 20. .17 c

ANISOU 4401 CG LYS c 166 1966 3081 2615 -424 652 -112 c

ATOM 4402 CD LYS c 166 -11.029 -27. ,193 1. .984 1. .00 19. .88 c

ANISOU 4402 CD LYS c 166 1865 3415 2270 100 618 -163 c

ATOM 4403 CE LYS c 166 -12.274 -27. ,213 1. .119 1. .00 26. .85 c

ANISOU 4403 CE LYS c 166 2486 4402 3310 517 -143 705 c

ATOM 4404 NZ LYS c 166 -12.425 -25. ,915 0. .432 1. .00 32. .46 N

ANISOU 4404 NZ LYS c 166 2872 4573 4889 1348 528 1021 N

ATOM 4405 N LYS c 167 -6.194 -29. ,770 2. .954 1. .00 13. .89 N

ANISOU 4405 N LYS c 167 1547 2463 1264 -54 313 62 N

ATOM 4406 CA LYS c 167 -4.856 -29. ,896 3. .578 1. .00 14. .38 C

ANISOU 4406 CA LYS c 167 1588 2598 1275 -431 253 179 C

ATOM 4407 C LYS c 167 -3.714 -29. ,569 2. .615 1. .00 15. .48 C

ANISOU 4407 C LYS c 167 1743 2695 1441 -148 510 109 C

ATOM 4408 O LYS c 167 -2.550 -29. ,749 2. .964 1. .00 15. .12 O

ANISOU 4408 O LYS c 167 1803 2813 1128 -363 181 185 O

ATOM 4409 CB LYS c 167 -4.653 -31. ,298 4. .134 1. .00 14. .58 C

ANISOU 4409 CB LYS c 167 2171 2578 789 -283 669 156 C

ATOM 4410 CG LYS c 167 -5.592 -31. ,649 5. .271 1. .00 16. .97 C

ANISOU 4410 CG LYS c 167 2566 2841 1041 -566 779 521 C

ATOM 4411 CD LYS c 167 -5.281 -33. ,061 5. .750 1. .00 21. .02 C ANISOU 4411 CD LYS C 167 3077 2780 2127 -163 572 439 C

ATOM 4412 CE LYS C 167 -6.328 -33. .582 6. .717 1. .00 22. .82 C

ANISOU 4412 CE LYS C 167 2949 3149 2570 239 730 908 C

ATOM 4413 NZ LYS C 167 -6.040 -34. .995 7. .099 1. .00 25. .99 N

ANISOU 4413 NZ LYS C 167 3620 2843 3410 -443 1497 878 N

ATOM 4414 N ALA C 168 -4.039 -29. .053 1. .430 1. .00 14. .96 N

ANISOU 4414 N ALA C 168 1657 2867 1159 -639 525 55 N

ATOM 4415 CA ALA C 168 -3.013 -28. .816 0. .398 1. .00 14. .00 C

ANISOU 4415 CA ALA C 168 1534 2504 1281 -470 534 71 C

ATOM 4416 C ALA C 168 -2.019 -27. .748 0. .832 1. .00 14. .74 C

ANISOU 4416 C ALA C 168 1551 2518 1529 -314 306 -182 C

ATOM 4417 O ALA C 168 -2.385 -26. .783 1. .514 1. .00 14. .64 O

ANISOU 4417 O ALA C 168 1376 2368 1814 -510 133 -241 O

ATOM 4418 CB ALA C 168 -3.661 -28. .412 -0. .910 1. .00 14. .58 C

ANISOU 4418 CB ALA C 168 1737 2567 1234 -471 337 -64 C

ATOM 4419 N LEU C 169 -0.763 -27. .914 0. .417 1. .00 14. .34 N

ANISOU 4419 N LEU C 169 1364 2278 1806 -374 80 -131 N

ATOM 4420 CA LEU C 169 0.268 -26. .942 0. .723 1. .00 13. .68 C

ANISOU 4420 CA LEU C 169 1494 1879 1823 -293 345 -239 C

ATOM 4421 C LEU C 169 0.083 -25. .661 -0. .099 1. .00 14. .09 C

ANISOU 4421 C LEU C 169 1693 2192 1465 -456 392 -128 C

ATOM 4422 O LEU C 169 -0.695 -25. .642 -1. .051 1. .00 14. .72 O

ANISOU 4422 O LEU C 169 1384 2390 1816 -316 256 -246 O

ATOM 4423 CB LEU c 169 1.638 -27. .561 0. .490 1. .00 12. .83 C

ANISOU 4423 CB LEU c 169 1474 2104 1297 -251 467 -40 C

ATOM 4424 CG LEU c 169 2.044 -28. .029 -0. .927 1. .00 11. .29 C

ANISOU 4424 CG LEU c 169 1476 1495 1319 -108 573 113 c

ATOM 4425 CD1 LEU c 169 2.438 -26. .882 -1. .861 1. .00 12. .46 c

ANISOU 4425 CD1 LEU c 169 1080 1844 1809 -533 454 359 c

ATOM 4426 CD2 LEU c 169 3.227 -28. .965 -0. .745 1. .00 13. .81 c

ANISOU 4426 CD2 LEU c 169 1704 1929 1611 Ill 71 333 c

ATOM 4427 N LYS c 170 0.781 -24. .596 0. .296 1. .00 15. .34 N

ANISOU 4427 N LYS c 170 1810 2338 1679 -307 153 -641 N

ATOM 4428 CA LYS c 170 0.779 -23. .325 -0. .424 1. .00 15. .85 C

ANISOU 4428 CA LYS c 170 1898 2098 2025 -243 397 -756 C

ATOM 4429 C LYS c 170 2.179 -22. .996 -0. .908 1. .00 15. .64 C

ANISOU 4429 C LYS c 170 2077 2115 1749 -61 565 -291 C

ATOM 4430 O LYS c 170 3.180 -23. .460 -0. .336 1. .00 16. .74 O

ANISOU 4430 O LYS c 170 2127 2339 1893 -11 270 -481 0

ATOM 4431 CB LYS c 170 0.318 -22. .171 0. .486 1. .00 19. .37 c

ANISOU 4431 CB LYS c 170 2363 2191 2806 236 650 -795 c

ATOM 4432 CG LYS c 170 -1.047 -22. .360 1. .120 1. .00 22. .77 c

ANISOU 4432 CG LYS c 170 2727 3011 2911 501 902 -173 c

ATOM 4433 CD LYS c 170 -1.527 -21. .065 1. .751 1. .00 24. .69 c

ANISOU 4433 CD LYS c 170 3397 3327 2657 407 823 -753 c

ATOM 4434 CE LYS c 170 -0.777 -20. .719 3. .024 1. .00 25. .94 c

ANISOU 4434 CE LYS c 170 4221 2541 3093 589 391 -842 c

ATOM 4435 NZ LYS c 170 -1.402 -19. .510 3. .623 1. .00 30. .83 N

ANISOU 4435 NZ LYS c 170 6506 2036 3172 641 -26 - 1139 N

ATOM 4436 N LEU c 171 2.244 -22. .143 -1. .919 1. .00 14. .76 N

ANISOU 4436 N LEU c 171 1918 2095 1592 -388 494 -344 N

ATOM 4437 CA LEU c 171 3.521 -21. .643 -2. .433 1. .00 16. .62 C

ANISOU 4437 CA LEU c 171 2024 2116 2172 -505 506 -203 C

ATOM 4438 C LEU c 171 3.518 -20. .131 -2. .336 1. .00 18. .63 C

ANISOU 4438 C LEU c 171 2607 2113 2358 -775 510 -472 C

ATOM 4439 O LEU c 171 2.465 -19. .520 -2. .418 1. .00 20. .94 O

ANISOU 4439 O LEU c 171 2898 2177 2882 -636 546 -376 O

ATOM 4440 CB LEU c 171 3.688 -22. .070 -3. .887 1. .00 17. .60 C

ANISOU 4440 CB LEU c 171 2236 2299 2150 -714 609 -216 C

ATOM 4441 CG LEU c 171 3.599 -23. .580 -4. .135 1. .00 13. .08 C

ANISOU 4441 CG LEU c 171 1672 2018 1278 -169 517 285 C ATOM 4442 CD1. LEU C 171 3.553 -23 916 -5.623 1 00 16.28 C

ANISOU 4442 CD1 . LEU C 171 1624 3136 1424 -356 231 -147 C

ATOM 4443 CD2 : LEU C 171 4.758 -24 301 -3.466 1 00 15.48 C

ANISOU 4443 CD2 : LEU C 171 1820 2668 1393 -189 196 482 C

ATOM 4444 N AMET C 172 4.690 -19 534 -2.140 0 50 19.66 N

ANISOU 4444 N AMET C 172 2591 2367 2510 -822 648 -528 N

ATOM 4445 CA AMET C 172 4.792 -18 082 -2.144 0 50 18.74 C

ANISOU 4445 CA AMET C 172 2452 2346 2320 -540 666 -428 C

ATOM 4446 C AMET C 172 5.430 -17 601 -3.442 0 50 18.96 C

ANISOU 4446 C AMET C 172 2582 2307 2314 -283 817 -459 C

ATOM 4447 O AMET C 172 6.453 -18 130 -3.870 0 50 19.59 O

ANISOU 4447 O AMET C 172 2035 2544 2865 -320 489 -422 O

ATOM 4448 CB AMET C 172 5.579 -17 568 -0.932 0 50 21.89 C

ANISOU 4448 CB AMET C 172 3110 2572 2635 -527 480 -895 C

ATOM 4449 CG AMET C 172 5.825 -16 072 -0.983 0 50 22.75 C

ANISOU 4449 CG AMET C 172 3126 2676 2839 -719 858 -821 C

ATOM 4450 SD AMET C 172 6.204 -15 358 0.619 0 50 30.21 S

ANISOU 4450 SD AMET C 172 4749 3534 3194 -1223 201 -983 S

ATOM 4451 CE AMET C 172 7.635 -16 300 1.078 0 50 22.62 C

ANISOU 4451 CE AMET C 172 3010 3098 2486 -1692 1536 -961 C

ATOM 4452 N BMET C 172 4.697 -19 531 -2.171 0 50 19.91 N

ANISOU 4452 N BMET C 172 2646 2443 2474 -877 594 -530 N

ATOM 4453 CA BMET c 172 4.822 -18 074 -2.114 0 50 18.83 C

ANISOU 4453 CA BMET c 172 2514 2426 2213 -667 520 -482 C

ATOM 4454 C BMET c 172 5.480 -17 535 -3.387 0 50 19.28 C

ANISOU 4454 C BMET c 172 2638 2326 2361 -459 687 -374 C

ATOM 4455 O BMET c 172 6.576 -17 959 -3.742 0 50 19.84 O

ANISOU 4455 O BMET c 172 2330 2284 2922 -610 558 -358 O

ATOM 4456 CB BMET c 172 5.626 -17 646 -0.874 0 50 22.16 C

ANISOU 4456 CB BMET c 172 3132 2834 2452 -634 312 -921 C

ATOM 4457 CG BMET c 172 5.777 -16 144 -0.722 0 50 24.09 C

ANISOU 4457 CG BMET c 172 3762 2983 2406 -998 509 -1149 C

ATOM 4458 SD BMET c 172 4.190 -15 315 -0.509 0 50 28.62 S

ANISOU 4458 SD BMET c 172 3828 3808 3236 -1056 1034 -1071 S

ATOM 4459 CE BMET c 172 3.870 -15 594 1.231 0 50 27.26 C

ANISOU 4459 CE BMET c 172 4106 3166 3085 -520 1790 -1888 C

ATOM 4460 N GLY c 173 4.801 -16 612 -4.068 1 00 18.36 N

ANISOU 4460 N GLY c 173 2685 2201 2088 -705 692 -165 N

ATOM 4461 CA GLY c 173 5.335 -15 982 -5.284 1 00 19.45 C

ANISOU 4461 CA GLY c 173 2773 2315 2299 -527 804 31 C

ATOM 4462 C GLY c 173 6.235 -14 804 -4.974 1 00 21.86 C

ANISOU 4462 C GLY c 173 2844 2613 2849 -671 1054 -204 C

ATOM 4463 O GLY c 173 6.481 -14 491 -3.802 1 00 23.87 O

ANISOU 4463 O GLY c 173 3197 2828 3042 -761 680 -491 O

ATOM 4464 N SER c 174 6.725 -14 149 -6.025 1 00 23.91 N

ANISOU 4464 N SER c 174 3457 2496 3131 -659 1223 8 N

ATOM 4465 CA SER c 174 7.690 -13 070 -5.881 1 00 26.85 C

ANISOU 4465 CA SER c 174 3108 2949 4143 -732 1636 -576 C

ATOM 4466 C SER c 174 7.034 -11 724 -5.664 1 00 28.52 C

ANISOU 4466 C SER c 174 3178 2562 5092 -1006 1906 -403 C

ATOM 4467 O SER c 174 7.719 -10 734 -5.446 1 00 32.77 O

ANISOU 4467 O SER c 174 4741 2227 5480 -1167 1886 -816 O

ATOM 4468 CB SER c 174 8.618 -12 994 -7.099 1 00 24.66 C

ANISOU 4468 CB SER c 174 2993 2528 3847 -367 1418 122 C

ATOM 4469 OG SER c 174 9.534 -14 071 -7.084 1 00 26.22 O

ANISOU 4469 OG SER c 174 2974 3289 3698 66 1249 -474 O

ATOM 4470 N ASN c 175 5.710 -11 693 -5.728 1 00 29.23 N

ANISOU 4470 N ASN c 175 3261 3250 4595 -741 I486 -764 N

ATOM 4471 CA ASN c 175 4.975 -10 455 -5.596 1 00 34.39 C

ANISOU 4471 CA ASN c 175 3992 3568 5506 -462 1585 -769 C

ATOM 4472 C ASN c 175 4.136 -10 508 -4.334 1 00 36.48 C ANISOU 4472 C ASN C 175 5444 3424 4991 -394 1690 -904 C

ATOM 4473 O ASN C 175 3.080 -9. ,885 -4. .252 1. .00 39. .68 O

ANISOU 4473 O ASN C 175 6028 3612 5436 -289 2130 -741 O

ATOM 4474 CB ASN C 175 4.093 -10. ,243 -6. .825 1. .00 39. .83 C

ANISOU 4474 CB ASN C 175 5431 4838 4864 349 1640 -131 C

ATOM 4475 CG ASN C 175 3.768 -8. ,783 -7. .065 1. .00 45. .93 C

ANISOU 4475 CG ASN C 175 6115 4744 6590 -489 770 -315 C

ATOM 4476 OD1 ASN C 175 4.418 -7. ,887 -6. .523 1. .00 48. .27 O

ANISOU 4476 OD1 ASN C 175 6353 5705 6283 -1736 1002 -133 O

ATOM 4477 ND2 ASN C 175 2.760 -8. ,535 -7. .890 1. .00 50. .94 N

ANISOU 4477 ND2 ASN C 175 5209 7026 7120 -62 961 -48 N

ATOM 4478 N GLU C 176 4.621 -11. ,256 -3. .385 1. .00 38. .89 N

ANISOU 4478 N GLU C 176 4851 4712 5210 -601 1645 -342 N

ATOM 4479 CA GLU C 176 3.941 -11. ,460 -2. .120 1. .00 35. .91 C

ANISOU 4479 CA GLU C 176 4249 4825 4567 6 1149 - 1490 C

ATOM 4480 C GLU C 176 2.698 -12. ,363 -2. .183 1. .00 40. .92 C

ANISOU 4480 C GLU C 176 5066 5266 5216 -882 2115 -353 C

ATOM 4481 O GLU C 176 2.241 -12. ,855 -1. .174 1. .00 47. .43 O

ANISOU 4481 O GLU C 176 5262 7625 5134 -1351 2015 -336 O

ATOM 4482 CB GLU C 176 3.609 -10. ,115 -1. .506 1. .00 28. .92 C

ANISOU 4482 CB GLU C 176 3388 3378 4222 -180 14 -141 C

ATOM 4483 CG GLU C 176 4.795 -9. ,174 -1. .479 1. .00 27. .74 C

ANISOU 4483 CG GLU C 176 3162 4082 3292 -140 107 -213 C

ATOM 4484 CD GLU C 176 5.068 -8. ,655 -0. .099 1. .00 28. .44 C

ANISOU 4484 CD GLU c 176 2847 4429 3528 219 -171 -418 C

ATOM 4485 OE1 GLU c 176 4.891 -9. ,430 0. .855 1. .00 34. .08 O

ANISOU 4485 OE1 GLU c 176 3577 4369 5001 200 616 -298 O

ATOM 4486 OE2 GLU c 176 5.466 -7. ,488 0. .032 1. .00 32. .81 O

ANISOU 4486 OE2 GLU c 176 3483 4733 4249 -4 -630 59 O

ATOM 4487 N GLY c 177 2.164 -12. ,589 -3. .347 1. .00 30. .54 N

ANISOU 4487 N GLY c 177 3288 2416 5897 -770 2241 - 1097 N

ATOM 4488 CA GLY c 177 0.978 -13. ,419 -3. .526 1. .00 29. .90 C

ANISOU 4488 CA GLY c 177 3997 2307 5055 -1171 1618 -688 C

ATOM 4489 C GLY c 177 1.261 -14. ,873 -3. .192 1. .00 26. .88 C

ANISOU 4489 C GLY c 177 2956 2916 4342 -461 2099 -429 C

ATOM 4490 O GLY c 177 2.406 -15. ,315 -3. .176 1. .00 36. .79 O

ANISOU 4490 O GLY c 177 2623 3696 7657 -661 1687 346 O

ATOM 4491 N GLU c 178 0.208 -15. ,627 -2. .925 1. .00 23. .02 N

ANISOU 4491 N GLU c 178 3567 2309 2869 -896 1376 -426 N

ATOM 4492 CA GLU c 178 0.356 -17. ,042 -2. .659 1. .00 19. .26 C

ANISOU 4492 CA GLU c 178 2407 2572 2338 -128 793 -315 C

ATOM 4493 C GLU c 178 -0.317 -17. ,849 -3. .759 1. .00 19. .59 C

ANISOU 4493 C GLU c 178 2604 2337 2499 -163 942 -501 C

ATOM 4494 O GLU c 178 -1.339 -17. ,417 -4. .314 1. .00 23. .78 O

ANISOU 4494 O GLU c 178 2271 3614 3147 -87 940 -433 O

ATOM 4495 CB GLU c 178 -0.246 -17. ,375 -1. .297 1. .00 24. .54 C

ANISOU 4495 CB GLU c 178 3987 3133 2202 -508 1035 -532 C

ATOM 4496 CG GLU c 178 0.486 -16. ,695 -0. .144 1. .00 27. .93 c

ANISOU 4496 CG GLU c 178 4757 3465 2389 -259 952 - 1098 c

ATOM 4497 CD GLU c 178 -0.171 -16. ,920 1. .206 1. .00 31. .70 c

ANISOU 4497 CD GLU c 178 4858 4114 3072 107 1615 -769 c

ATOM 4498 OE1 GLU c 178 -1.139 -17. ,707 1. .286 1. .00 32. .83 0

ANISOU 4498 OE1 GLU c 178 5592 3929 2953 -324 1807 -268 0

ATOM 4499 OE2 GLU c 178 0.283 -16. ,294 2. .191 1. .00 39. .53 0

ANISOU 4499 OE2 GLU c 178 6396 5371 3250 757 1082 - 1235 0

ATOM 4500 N PHE c 179 0.260 -19. ,003 -4. .087 1. .00 17. .47 N

ANISOU 4500 N PHE c 179 2135 2166 2336 -267 920 -256 N

ATOM 4501 CA PHE c 179 -0.378 -19. ,937 -5. .025 1. .00 17. .15 C

ANISOU 4501 CA PHE c 179 2182 2196 2136 -346 948 -178 C

ATOM 4502 C PHE c 179 -0.955 -21. ,083 -4. .214 1. .00 17. .65 C

ANISOU 4502 C PHE c 179 2114 2522 2070 -408 678 130 C ATOM 4503 O PHE C 179 -0.281 -21..645 -3..338 1..00 18..97 O

ANISOU 4503 O PHE C 179 2060 2650 2496 -409 445 112 O

ATOM 4504 CB PHE C 179 0.602 -20. .444 -6. .092 1. .00 16. .17 C

ANISOU 4504 CB PHE C 179 1748 2459 1933 -348 843 79 C

ATOM 4505 CG PHE C 179 1.466 -19. .356 -6. .666 1. .00 17. .30 C

ANISOU 4505 CG PHE C 179 1643 2673 2257 -167 1278 242 C

ATOM 4506 CD1 PHE C 179 0.906 -18. .143 -7. .073 1. .00 18. .63 C

ANISOU 4506 CD1 PHE C 179 2227 2246 2605 -158 1773 64 C

ATOM 4507 CD2 PHE C 179 2.844 -19. .522 -6. .771 1. .00 17. .20 C

ANISOU 4507 CD2 PHE C 179 1705 2636 2194 -42 1510 212 C

ATOM 4508 CE1 PHE C 179 1.687 -17. .118 -7. .572 1. .00 18. .46 C

ANISOU 4508 CE1 PHE C 179 2265 2038 2708 -179 1123 387 C

ATOM 4509 CE2 PHE C 179 3.634 -18. .496 -7. .275 1. .00 21. .52 C

ANISOU 4509 CE2 PHE C 179 3023 2173 2978 -268 1204 638 C

ATOM 4510 CZ PHE C 179 3.047 -17. .294 -7. .678 1. .00 19. .78 C

ANISOU 4510 CZ PHE C 179 2380 2337 2797 -60 1673 513 C

ATOM 4511 N LYS C 180 -2.215 -21. .402 -4. .491 1. .00 17. .01 N

ANISOU 4511 N LYS C 180 2117 2243 2103 -227 401 183 N

ATOM 4512 CA LYS C 180 -2.980 -22. .309 -3. .657 1. .00 15. .83 C

ANISOU 4512 CA LYS C 180 1944 2197 1871 -187 499 -92 C

ATOM 4513 C LYS C 180 -3.732 -23. .352 -4. .466 1. .00 16. .79 C

ANISOU 4513 C LYS C 180 2335 2010 2032 -201 423 -60 C

ATOM 4514 O LYS C 180 -3.850 -23. .247 -5. .686 1. .00 17. .45 O

ANISOU 4514 O LYS C 180 2201 2511 1915 -11 705 144 O

ATOM 4515 CB LYS c 180 -3.998 -21. .517 -2. .826 1. .00 17. .77 C

ANISOU 4515 CB LYS c 180 2082 2383 2287 -107 714 -147 C

ATOM 4516 CG LYS c 180 -3.375 -20. .524 -1. .870 1. .00 21. .67 c

ANISOU 4516 CG LYS c 180 2567 2744 2920 -360 197 -160 c

ATOM 4517 CD LYS c 180 -4.431 -19. .976 -0. .943 1. .00 27. .89 c

ANISOU 4517 CD LYS c 180 3834 3971 2792 346 927 268 c

ATOM 4518 CE LYS c 180 -4.019 -18. .622 -0. .415 1. .00 31. .96 c

ANISOU 4518 CE LYS c 180 3239 5557 3347 687 2288 - 1210 c

ATOM 4519 NZ LYS c 180 -5.112 -18. .099 0. .417 1. .00 32. .00 N

ANISOU 4519 NZ LYS c 180 4291 6607 1260 4449 808 -216 N

ATOM 4520 N ALA c 181 -4.269 -24. .343 -3. .761 1. .00 17. .32 N

ANISOU 4520 N ALA c 181 2012 2148 2419 -86 767 20 N

ATOM 4521 CA ALA c 181 -5.120 -25. .357 -4. .368 1. .00 15. .30 C

ANISOU 4521 CA ALA c 181 1619 1953 2242 194 344 170 C

ATOM 4522 C ALA c 181 -6.454 -24. .773 -4. .838 1. .00 16. .84 C

ANISOU 4522 C ALA c 181 1754 2192 2452 249 138 -23 C

ATOM 4523 O ALA c 181 -6.979 -25. .185 -5. .875 1. .00 17. .63 O

ANISOU 4523 O ALA c 181 1529 2588 2580 164 105 -194 O

ATOM 4524 CB ALA c 181 -5.357 -26. .505 -3. .390 1. .00 13. .98 C

ANISOU 4524 CB ALA c 181 1554 1834 1923 -55 359 -54 C

ATOM 4525 N GLU c 182 -6.993 -23. .828 -4. .066 1. .00 15. .61 N

ANISOU 4525 N GLU c 182 1036 2036 2858 358 -7 -20 N

ATOM 4526 CA GLU c 182 -8.329 -23. .265 -4. .310 1. .00 19. .95 C

ANISOU 4526 CA GLU c 182 1436 2543 3601 1079 445 347 C

ATOM 4527 C GLU c 182 -8.310 -21. .757 -4. .124 1. .00 22. .87 C

ANISOU 4527 C GLU c 182 2197 2612 3881 951 423 503 C

ATOM 4528 O GLU c 182 -7.251 -21. .172 -3. .881 1. .00 26. .09 O

ANISOU 4528 O GLU c 182 2324 3075 4513 1013 771 -791 O

ATOM 4529 CB GLU c 182 -9.345 -23. .895 -3. .351 1. .00 23. .23 C

ANISOU 4529 CB GLU c 182 2165 2777 3881 185 501 338 C

ATOM 4530 CG GLU c 182 -9.416 -25. .416 -3. .417 1. .00 21. .90 c

ANISOU 4530 CG GLU c 182 2374 2901 3045 -378 347 381 c

ATOM 4531 CD GLU c 182 -10.489 -25. .981 -2. .506 1. .00 25. .08 c

ANISOU 4531 CD GLU c 182 3045 3697 2786 -173 812 424 c

ATOM 4532 OE1 GLU c 182 -10.214 -26. .153 -1. .299 1. .00 23. .54 0

ANISOU 4532 OE1 GLU c 182 3119 3002 2819 53 648 438 0

ATOM 4533 OE2 GLU c 182 -11.601 -26. .267 -2. .997 1. .00 31. .16 0 ANISOU 4533 OE2 GLU C 182 2886 4175 4777 -841 872 64 O

ATOM 4534 N GLY C 183 -9.483 -21. .134 -4. .241 1. .00 26. .57 N

ANISOU 4534 N GLY C 183 2294 3153 4646 1326 1269 916 N

ATOM 4535 CA GLY C 183 -9.621 -19. .691 -4. .094 1. .00 27. .80 C

ANISOU 4535 CA GLY C 183 2912 2996 4654 739 705 699 C

ATOM 4536 C GLY C 183 -9.476 -18. .983 -5. .429 1. .00 29. .65 C

ANISOU 4536 C GLY C 183 3217 3005 5041 431 1050 841 C

ATOM 4537 O GLY C 183 -9.730 -19. .570 -6. .485 1. .00 32. .36 O

ANISOU 4537 O GLY C 183 3449 3861 4983 787 805 638 O

ATOM 4538 N ASN C 184 -9.071 -17. .718 -5. .373 1. .00 31. .31 N

ANISOU 4538 N ASN C 184 3726 2767 5400 670 795 391 N

ATOM 4539 CA ASN C 184 -8.868 -16. .885 -6. .563 1. .00 31. .86 C

ANISOU 4539 CA ASN C 184 3928 2912 5265 346 921 393 C

ATOM 4540 C ASN C 184 -8.183 -17. .681 -7. .683 1. .00 27. .87 C

ANISOU 4540 C ASN C 184 2850 3288 4451 397 649 956 C

ATOM 4541 O ASN C 184 -7.058 -18. .131 -7. .513 1. .00 29. .30 O

ANISOU 4541 O ASN C 184 3369 3001 4760 1121 662 1083 O

ATOM 4542 CB ASN C 184 -8.049 -15. .649 -6. .162 1. .00 31. .22 C

ANISOU 4542 CB ASN C 184 3594 2674 5593 316 1235 692 C

ATOM 4543 CG ASN C 184 -7.944 -14. .605 -7. .266 1. .00 33. .40 c

ANISOU 4543 CG ASN C 184 4851 1675 6165 163 871 462 c

ATOM 4544 OD1 ASN C 184 -8.076 -14. .899 -8. .458 1. .00 33. .96 0

ANISOU 4544 OD1 ASN c 184 3625 2980 6297 669 362 575 0

ATOM 4545 ND2 ASN c 184 -7.689 -13. .364 -6. .862 1. .00 40. .80 N

ANISOU 4545 ND2 ASN c 184 6322 1688 7491 -375 1624 387 N

ATOM 4546 N SER c 185 -8.878 -17. .873 -8. .805 1. .00 27. .94 N

ANISOU 4546 N SER c 185 3082 2733 4800 114 160 1049 N

ATOM 4547 CA SER c 185 -8.396 -18. .747 -9. .892 1. .00 29. .14 C

ANISOU 4547 CA SER c 185 2909 3390 4773 162 211 1044 C

ATOM 4548 C SER c 185 -7.173 -18. .214 -10. .638 1. .00 26. .61 C

ANISOU 4548 C SER c 185 2886 2724 4498 750 470 1016 C

ATOM 4549 O SER c 185 -6.533 -18. .956 -11. .374 1. .00 26. .95 O

ANISOU 4549 O SER c 185 2936 3145 4158 784 303 846 O

ATOM 4550 CB SER c 185 -9.517 -19. .058 -10. .900 1. .00 24. .57 C

ANISOU 4550 CB SER c 185 3747 3032 2557 1274 -63 2285 C

ATOM 4551 OG SER c 185 -9.830 -17. .949 -11. .688 1. .00 36. .47 O

ANISOU 4551 OG SER c 185 5795 2858 5201 1061 -674 2926 O

ATOM 4552 N LYS c 186 -6.867 -16. .931 -10. .457 1. .00 24. .90 N

ANISOU 4552 N LYS c 186 1774 2763 4923 712 -133 1171 N

ATOM 4553 CA LYS c 186 -5.670 -16. .320 -11. .029 1. .00 28. .56 C

ANISOU 4553 CA LYS c 186 2364 3495 4990 697 414 1250 C

ATOM 4554 C LYS c 186 -4.424 -16. .828 -10. .308 1. .00 24. .58 C

ANISOU 4554 C LYS c 186 2279 3301 3758 329 498 1124 C

ATOM 4555 O LYS c 186 -3.317 -16. .733 -10. .836 1. .00 24. .46 O

ANISOU 4555 O LYS c 186 2797 3352 3144 589 1005 898 O

ATOM 4556 CB LYS c 186 -5.717 -14. .798 -10. .898 1. .00 30. .85 C

ANISOU 4556 CB LYS c 186 2695 3585 5440 679 411 1518 C

ATOM 4557 CG LYS c 186 -6.867 -14. .116 -11. .612 1. .00 35. .64 c

ANISOU 4557 CG LYS c 186 2828 4820 5890 601 -39 2255 c

ATOM 4558 CD LYS c 186 -6.958 -12. .661 -11. .170 1. .00 37. .90 c

ANISOU 4558 CD LYS c 186 3681 5200 5516 52 -86 1859 c

ATOM 4559 CE LYS c 186 -8.247 -12. .002 -11. .632 1. .00 50. .34 c

ANISOU 4559 CE LYS c 186 4685 7622 6820 1481 -57 2232 c

ATOM 4560 NZ LYS c 186 -8.301 -11. .829 -13. .110 1. .00 57. .04 N

ANISOU 4560 NZ LYS c 186 5798 8878 6995 930 -318 2751 N

ATOM 4561 N PHE c 187 -4.613 -17. .345 -9. .095 1. .00 21. .40 N

ANISOU 4561 N PHE c 187 2168 2493 3468 -65 566 685 N

ATOM 4562 CA PHE c 187 -3.506 -17. .724 -8. .221 1. .00 22. .98 C

ANISOU 4562 CA PHE c 187 3161 2674 2895 176 204 293 C

ATOM 4563 C PHE c 187 -3.464 -19. .213 -7. .861 1. .00 19. .61 C

ANISOU 4563 C PHE c 187 2274 2555 2619 264 572 84 C ATOM 4564 O PHE C 187 -2.665 -19..630 -7..022 1..00 19..41 O

ANISOU 4564 O PHE C 187 1943 2690 2741 -129 395 82 O

ATOM 4565 CB PHE C 187 -3.549 -16. .882 -6. .933 1. .00 24. .49 C

ANISOU 4565 CB PHE C 187 3450 2676 3177 -23 707 98 C

ATOM 4566 CG PHE C 187 -3.127 -15. .452 -7. .126 1. .00 30. .52 C

ANISOU 4566 CG PHE C 187 4503 2661 4432 -249 460 -37 C

ATOM 4567 CD1 PHE C 187 -4.052 -14. .477 -7. .487 1. .00 30. .47 C

ANISOU 4567 CD1 PHE C 187 4987 2128 4462 -257 409 ^■148 C

ATOM 4568 CD2 PHE C 187 -1.796 -15. .079 -6. .942 1. .00 28. .26 C

ANISOU 4568 CD2 PHE C 187 4125 2312 4299 121 1098 -97 C

ATOM 4569 CE1 PHE C 187 -3.656 -13. .155 -7. .668 1. .00 30. .78 C

ANISOU 4569 CE1 PHE C 187 4119 2719 4854 -858 1301 308 C

ATOM 4570 CE2 PHE C 187 -1.391 -13. .758 -7. .120 1. .00 33. .73 C

ANISOU 4570 CE2 PHE C 187 5286 2203 5324 338 351 654 C

ATOM 4571 CZ PHE C 187 -2.325 -12. .795 -7. .480 1. .00 29. .44 C

ANISOU 4571 CZ PHE C 187 4264 2078 4843 -164 380 602 C

ATOM 4572 N THR C 188 -4.319 -20. .026 -8. .464 1. .00 18. .77 N

ANISOU 4572 N THR C 188 2344 2451 2334 551 212 224 N

ATOM 4573 CA THR C 188 -4.263 -21. .466 -8. .172 1. .00 17. .57 C

ANISOU 4573 CA THR C 188 2074 2335 2264 441 438 -30 C

ATOM 4574 C THR C 188 -3.156 -22. .139 -8. .976 1. .00 16. .17 C

ANISOU 4574 C THR C 188 1908 2058 2176 407 274 51 C

ATOM 4575 O THR C 188 -2.968 -21. .842 -10. .153 1. .00 19. .41 O

ANISOU 4575 O THR c 188 2273 2769 2332 468 -46 408 O

ATOM 4576 CB THR c 188 -5.587 -22. .176 -8. .462 1. .00 17. .70 C

ANISOU 4576 CB THR c 188 1909 2699 2113 421 746 75 C

ATOM 4577 OG1 THR c 188 -6.028 -21. .825 -9. .774 1. .00 21. .39 0

ANISOU 4577 OG1 THR c 188 2305 3207 2613 -183 -71 164 0

ATOM 4578 CG2 THR c 188 -6.643 -21. .762 -7. .418 1. .00 18. .75 c

ANISOU 4578 CG2 THR c 188 1427 3263 2432 997 450 -69 c

ATOM 4579 N TYR c 189 -2.423 -23. .040 -8. .330 1. .00 14. .42 N

ANISOU 4579 N TYR c 189 1177 2325 1975 303 -84 ^■237 N

ATOM 4580 CA TYR c 189 -1.471 -23. .865 -9. .037 1. .00 13. .72 C

ANISOU 4580 CA TYR c 189 1338 2383 1490 149 79 ^■150 C

ATOM 4581 C TYR c 189 -2.187 -25. .067 -9. .693 1. .00 14. .53 C

ANISOU 4581 C TYR c 189 1439 2071 2009 -45 487 -10 C

ATOM 4582 O TYR c 189 -3.410 -25. .258 -9. .519 1. .00 15. .10 O

ANISOU 4582 O TYR c 189 1244 2448 2045 28 269 48 O

ATOM 4583 CB TYR c 189 -0.331 -24. .302 -8. .100 1. .00 13. .71 c

ANISOU 4583 CB TYR c 189 1808 2298 1101 87 15 -23 c

ATOM 4584 CG TYR c 189 -0.746 -24. .979 -6. .813 1. .00 13. .63 c

ANISOU 4584 CG TYR c 189 1700 2018 1459 -301 316 -55 c

ATOM 4585 CD1 TYR c 189 -1.474 -26. .184 -6. .820 1. .00 14. .46 c

ANISOU 4585 CD1 TYR c 189 1647 2180 1667 -391 21 62 c

ATOM 4586 CD2 TYR c 189 -0.356 -24. .449 -5. .577 1. .00 14. .90 c

ANISOU 4586 CD2 TYR c 189 2030 2249 1382 -369 201 72 c

ATOM 4587 CE1 TYR c 189 -1.835 -26. .814 -5. .634 1. .00 13. .58 c

ANISOU 4587 CE1 TYR c 189 1657 2089 1414 -43 99 ^■114 c

ATOM 4588 CE2 TYR c 189 -0.714 -25. .076 -4. .380 1. .00 12. .92 c

ANISOU 4588 CE2 TYR c 189 1521 2114 1271 -176 391 ^■118 c

ATOM 4589 CZ TYR c 189 -1.450 -26. .262 -4. .417 1. .00 13. .68 c

ANISOU 4589 CZ TYR c 189 1837 1898 1459 -136 129 ^■167 c

ATOM 4590 OH TYR c 189 -1.804 -26. .902 -3. .242 1. .00 13. .31 0

ANISOU 4590 OH TYR c 189 1480 2137 1436 -266 91 ^■202 0

ATOM 4591 N THR c 190 -1.447 -25. .849 -10. .476 1. .00 13. .10 N

ANISOU 4591 N THR c 190 1001 2266 1709 203 319 204 N

ATOM 4592 CA THR c 190 -1.966 -27. .112 -11. .008 1. .00 16. .12 c

ANISOU 4592 CA THR c 190 1639 2186 2299 -37 29 463 c

ATOM 4593 C THR c 190 -1.067 -28. .244 -10. .534 1. .00 14. .63 c

ANISOU 4593 C THR c 190 1591 1801 2167 -160 240 199 c

ATOM 4594 O THR c 190 0.111 -28. .039 -10. .236 1. .00 18. .63 0 ANISOU 4594 O THR C 190 1502 2813 2763 14 121 371 O

ATOM 4595 CB THR C 190 -2.061 -27. ,131 -12. .547 1. .00 19. .85 C

ANISOU 4595 CB THR C 190 2608 2507 2426 297 -474 379 C

ATOM 4596 OG1 THR C 190 -0.757 -27. ,164 -13. .107 1. .00 26. .98 O

ANISOU 4596 OG1 THR C 190 3445 3784 3022 910 319 401 O

ATOM 4597 CG2 THR C 190 -2.802 -25. ,889 -13. .086 1. .00 19. .74 C

ANISOU 4597 CG2 THR C 190 2790 2731 1976 731 -428 239 C

ATOM 4598 N VAL C 191 -1.636 -29. ,434 -10. .455 1. .00 12. .18 N

ANISOU 4598 N VAL C 191 1003 2006 1618 -310 275 279 N

ATOM 4599 CA VAL C 191 -0.934 -30. ,586 -9. .908 1. .00 12. .92 C

ANISOU 4599 CA VAL C 191 1324 2078 1505 -117 66 1 C

ATOM 4600 C VAL C 191 -0.718 -31. ,603 -11. .022 1. .00 13. .95 C

ANISOU 4600 C VAL C 191 1156 2569 1574 306 571 -91 C

ATOM 4601 O VAL C 191 -1.659 -32. ,040 -11. .688 1. .00 15. .58 O

ANISOU 4601 O VAL C 191 1364 3103 1451 62 670 -162 O

ATOM 4602 CB VAL C 191 -1.726 -31. ,179 -8. .734 1. .00 12. .88 C

ANISOU 4602 CB VAL C 191 1810 1849 1231 -54 341 -481 C

ATOM 4603 CGI VAL C 191 -1.126 -32. ,509 -8. .287 1. .00 14. .84 C

ANISOU 4603 CGI VAL c 191 1920 2073 1643 -149 66 22 c

ATOM 4604 CG2 VAL c 191 -1.746 -30. ,170 -7. .573 1. .00 13. .60 c

ANISOU 4604 CG2 VAL c 191 1856 2155 1154 7 467 -555 c

ATOM 4605 N LEU c 192 0.531 -31. ,981 -11. .243 1. .00 13. .12 N

ANISOU 4605 N LEU c 192 905 2502 1578 -15 431 -35 N

ATOM 4606 CA LEU c 192 0.857 -32. ,830 -12. .380 1. .00 12. .82 C

ANISOU 4606 CA LEU c 192 1145 2297 1428 60 535 133 C

ATOM 4607 C LEU c 192 0.877 -34. ,318 -12. .035 1. .00 13. .57 C

ANISOU 4607 C LEU c 192 1418 2276 1462 -416 638 93 C

ATOM 4608 O LEU c 192 0.687 -35. ,169 -12. .906 1. .00 16. .42 O

ANISOU 4608 O LEU c 192 1874 2836 1525 -354 342 -125 O

ATOM 4609 CB LEU c 192 2.202 -32. ,394 -12. .994 1. .00 13. .43 c

ANISOU 4609 CB LEU c 192 926 2342 1833 18 456 -73 c

ATOM 4610 CG LEU c 192 2.332 -30. ,915 -13. .403 1. .00 16. .86 c

ANISOU 4610 CG LEU c 192 1771 2702 1932 91 -16 549 c

ATOM 4611 CD1 LEU c 192 3.709 -30. ,616 -13. .980 1. .00 17. .15 c

ANISOU 4611 CD1 LEU c 192 2235 2175 2105 -327 391 138 c

ATOM 4612 CD2 LEU c 192 1.236 -30. ,457 -14. .365 1. .00 18. .54 c

ANISOU 4612 CD2 LEU c 192 2278 2860 1904 595 15 721 c

ATOM 4613 N GLU c 193 1.158 -34. ,620 -10. .771 1. .00 13. .22 N

ANISOU 4613 N GLU c 193 1210 2339 1472 -56 834 232 N

ATOM 4614 CA GLU c 193 1.067 -35. ,976 -10. .227 1. .00 14. .27 C

ANISOU 4614 CA GLU c 193 1671 2134 1617 -20 809 18 C

ATOM 4615 C GLU c 193 0.920 -35. ,844 -8. .721 1. .00 15. .69 C

ANISOU 4615 C GLU c 193 2085 2311 1562 -370 405 -47 C

ATOM 4616 O GLU c 193 1.406 -34. ,857 -8. .133 1. .00 14. .97 0

ANISOU 4616 O GLU c 193 1578 2142 1968 -488 514 60 0

ATOM 4617 CB GLU c 193 2.294 -36. ,828 -10. .609 1. .00 15. .85 c

ANISOU 4617 CB GLU c 193 1446 2711 1864 19 916 137 c

ATOM 4618 CG GLU c 193 3.596 -36. ,534 -9. .880 1. .00 21. .55 c

ANISOU 4618 CG GLU c 193 1941 3230 3015 45 323 74 c

ATOM 4619 CD GLU c 193 4.750 -37. ,385 -10. .405 1. .00 22. .06 c

ANISOU 4619 CD GLU c 193 2340 3533 2507 167 674 -2 c

ATOM 4620 OE1 GLU c 193 5.303 -37. ,060 -11. .465 1. .00 25. .74 0

ANISOU 4620 OE1 GLU c 193 2862 4536 2380 1025 751 273 0

ATOM 4621 OE2 GLU c 193 5.118 -38. ,388 -9. .763 1. .00 24. .12 0

ANISOU 4621 OE2 GLU c 193 2205 3858 3099 789 926 72 0

ATOM 4622 N ASP c 194 0.260 -36. ,816 -8. .090 1. .00 13. .45 N

ANISOU 4622 N ASP c 194 1474 2221 1415 -225 330 -97 N

ATOM 4623 CA ASP c 194 0.005 -36. ,727 -6. .642 1. .00 14. .58 C

ANISOU 4623 CA ASP c 194 1670 2440 1429 -161 293 -58 C

ATOM 4624 C ASP c 194 0.173 -38. ,065 -5. .959 1. .00 15. .69 c

ANISOU 4624 C ASP c 194 1487 2412 2062 -252 98 56 c ATOM 4625 O ASP C 194 -0.765 -38.,846 -5..886 1..00 15..99 O

ANISOU 4625 O ASP C 194 1963 1899 2211 -303 544 259 O

ATOM 4626 CB ASP C 194 -1.398 -36. ,154 -6. .367 1. .00 16. .60 C

ANISOU 4626 CB ASP C 194 1640 3047 1619 -163 445 -139 C

ATOM 4627 CG ASP C 194 -1.612 -35. ,758 -4. .901 1. .00 16. .02 C

ANISOU 4627 CG ASP C 194 1835 2527 1723 -142 273 -341 C

ATOM 4628 OD1 ASP C 194 -0.693 -35. ,938 -4. .070 1. .00 16. .16 O

ANISOU 4628 OD1 ASP C 194 1443 2707 1987 -501 351 -112 O

ATOM 4629 OD2 ASP C 194 -2.719 -35. ,266 -4. .577 1. .00 14. .87 O

ANISOU 4629 OD2 ASP C 194 1964 2115 1569 -43 421 155 O

ATOM 4630 N GLY C 195 1.381 -38. ,320 -5. .450 1. .00 13. .34 N

ANISOU 4630 N GLY C 195 1194 2096 1776 -176 488 235 N

ATOM 4631 CA GLY C 195 1.647 -39. ,569 -4. .757 1. .00 14. .65 C

ANISOU 4631 CA GLY C 195 1627 2104 1835 47 109 125 C

ATOM 4632 C GLY C 195 1.588 -39. ,488 -3. .252 1. .00 15. .36 C

ANISOU 4632 C GLY C 195 1826 2156 1854 -176 209 183 C

ATOM 4633 O GLY C 195 1.934 -40. ,464 -2. .568 1. .00 17. .85 O

ANISOU 4633 O GLY c 195 2562 2067 2153 -151 - 167 166 O

ATOM 4634 N CYS c 196 1.145 -38. ,342 -2. .731 1. .00 15. .08 N

ANISOU 4634 N CYS c 196 2196 1961 1572 -106 -72 351 N

ATOM 4635 CA CYS c 196 1.202 -38. ,072 -1. .283 1. .00 16. .31 C

ANISOU 4635 CA CYS c 196 2051 2425 1720 -110 -37 -55 C

ATOM 4636 C CYS c 196 -0.141 -38. ,201 -0. .565 1. .00 17. .48 C

ANISOU 4636 C CYS c 196 2189 2760 1691 -356 -54 438 C

ATOM 4637 O CYS c 196 -0.292 -37. ,732 0. .571 1. .00 17. .12 O

ANISOU 4637 O CYS c 196 1959 2822 1722 -83 104 452 O

ATOM 4638 CB CYS c 196 1.779 -36. ,668 -1. .056 1. .00 14. .70 C

ANISOU 4638 CB CYS c 196 2000 2065 1520 92 192 257 C

ATOM 4639 SG CYS c 196 3.448 -36. ,470 -1. .735 1. .00 17. .95 s

ANISOU 4639 SG CYS c 196 2066 2778 1974 -135 200 484 s

ATOM 4640 N THR c 197 -1.117 -38. ,839 -1. .210 1. .00 17. .13 N

ANISOU 4640 N THR c 197 2155 2146 2207 -465 97 370 N

ATOM 4641 CA THR c 197 -2.510 -38. ,769 -0. .715 1. .00 17. .68 C

ANISOU 4641 CA THR c 197 2192 2233 2291 -638 183 482 C

ATOM 4642 C THR c 197 -2.789 -39. ,568 0. .555 1. .00 18. .02 C

ANISOU 4642 C THR c 197 2448 2154 2243 -586 291 388 C

ATOM 4643 O THR c 197 -3.836 -39. ,383 1. .199 1. .00 18. .54 O

ANISOU 4643 O THR c 197 2758 1793 2494 -113 537 323 O

ATOM 4644 CB THR c 197 -3.533 -39. ,165 -1. .795 1. .00 16. .67 C

ANISOU 4644 CB THR c 197 2553 1965 1816 -328 92 361 c

ATOM 4645 OG1 THR c 197 -3.358 -40. ,547 -2. .119 1. .00 17. .70 0

ANISOU 4645 OG1 THR c 197 2445 2029 2248 -326 340 127 0

ATOM 4646 CG2 THR c 197 -3.340 -38. ,311 -3. .038 1. .00 15. .66 c

ANISOU 4646 CG2 THR c 197 2037 2314 1596 -91 102 347 c

ATOM 4647 N LYS c 198 -1.879 -40. ,463 0. .910 1. .00 19. .36 N

ANISOU 4647 N LYS c 198 2053 2975 2327 -587 - 182 464 N

ATOM 4648 CA LYS c 198 -2.018 -41. ,178 2. .173 1. .00 23. .28 C

ANISOU 4648 CA LYS c 198 2778 3604 2462 -349 241 675 C

ATOM 4649 C LYS c 198 -0.708 -41. ,384 2. .933 1. .00 25. .33 C

ANISOU 4649 C LYS c 198 2907 4006 2708 -58 239 1189 C

ATOM 4650 O LYS c 198 0.385 -41. ,348 2. .360 1. .00 30. .94 O

ANISOU 4650 O LYS c 198 3279 5230 3247 -312 781 953 0

ATOM 4651 CB LYS c 198 -2.795 -42. ,492 2. .011 1. .00 27. .81 c

ANISOU 4651 CB LYS c 198 3518 3540 3506 -401 297 677 c

ATOM 4652 CG LYS c 198 -2.401 -43. ,345 0. .832 1. .00 33. .02 c

ANISOU 4652 CG LYS c 198 5213 4551 2779 191 589 1110 c

ATOM 4653 N HIS c 199 -0.839 -41. ,556 4. .241 1. .00 22. .43 N

ANISOU 4653 N HIS c 199 2602 3353 2567 -148 378 514 N

ATOM 4654 CA HIS c 199 0.286 -41. ,947 5. .076 1. .00 23. .16 C

ANISOU 4654 CA HIS c 199 2224 3048 3526 -312 336 1012 C

ATOM 4655 C HIS c 199 0.524 -43. ,425 4. .887 1. .00 24. .87 C ANISOU 4655 C HIS C 199 2158 2638 4654 -1235 820 1565 C

ATOM 4656 O HIS C 199 -0.301 -44. ,237 5. .291 1. .00 23. .85 O

ANISOU 4656 O HIS C 199 1745 2376 4938 -845 1355 1614 O

ATOM 4657 CB HIS C 199 -0.015 -41. ,638 6. .537 1. .00 25. .71 C

ANISOU 4657 CB HIS C 199 2946 3357 3462 -170 240 895 C

ATOM 4658 CG HIS C 199 -0.176 -40. ,161 6. .847 1. .00 22. .46 C

ANISOU 4658 CG HIS C 199 2107 3412 3013 -193 -18 589 C

ATOM 4659 ND1 HIS C 199 -0.067 -39. ,675 8. .097 1. .00 21. .21 N

ANISOU 4659 ND1 HIS C 199 2186 3360 2513 -5 65 998 N

ATOM 4660 CD2 HIS C 199 -0.435 -39. ,063 6. .019 1. .00 24. .61 C

ANISOU 4660 CD2 HIS C 199 2413 3483 3452 14 -324 558 C

ATOM 4661 CE1 HIS C 199 -0.254 -38. ,336 8. .082 1. .00 21. .83 C

ANISOU 4661 CE1 HIS C 199 1440 3289 3563 -821 -638 459 C

ATOM 4662 NE2 HIS C 199 -0.479 -37. ,962 6. .808 1. .00 25. .53 N

ANISOU 4662 NE2 HIS C 199 2066 4196 3435 -488 -183 207 N

ATOM 4663 N THR C 200 1.644 -43. ,791 4. .254 1. .00 27. .80 N

ANISOU 4663 N THR C 200 2847 3174 4541 299 481 1212 N

ATOM 4664 CA THR C 200 1.960 -45. ,207 3. .985 1. .00 27. .69 C

ANISOU 4664 CA THR C 200 3005 3269 4246 478 -16 1442 C

ATOM 4665 C THR c 200 3.261 -45. ,645 4. .638 1. .00 23. .92 C

ANISOU 4665 C THR c 200 2112 2964 4012 -177 528 1701 C

ATOM 4666 O THR c 200 3.652 -46. ,818 4. .535 1. .00 30. .43 O

ANISOU 4666 O THR c 200 3744 2763 5054 63 186 2106 O

ATOM 4667 CB THR c 200 2.134 -45. ,499 2. .481 1. .00 28. .07 C

ANISOU 4667 CB THR c 200 2898 3968 3800 547 -654 1623 C

ATOM 4668 OG1 THR c 200 3.284 -44. ,790 2. .001 1. .00 31. .17 O

ANISOU 4668 OG1 THR c 200 4171 3529 4141 650 584 1464 O

ATOM 4669 CG2 THR c 200 0.878 -45. ,126 1. .673 1. .00 26. .35 C

ANISOU 4669 CG2 THR c 200 2119 3851 4038 650 -136 1442 C

ATOM 4670 N GLY c 201 3.949 -44. ,700 5. .275 1. .00 26. .79 N

ANISOU 4670 N GLY c 201 2366 3437 4374 -452 358 1637 N

ATOM 4671 CA GLY c 201 5.269 -44. ,977 5. .873 1. .00 29. .96 C

ANISOU 4671 CA GLY c 201 2354 3904 5124 -182 226 1611 C

ATOM 4672 C GLY c 201 6.380 -44. ,953 4. .839 1. .00 30. .82 C

ANISOU 4672 C GLY c 201 3224 4061 4424 291 361 1468 C

ATOM 4673 O GLY c 201 7.556 -45. ,099 5. .170 1. .00 33. .42 O

ANISOU 4673 O GLY c 201 3017 4456 5223 -183 420 2177 O

ATOM 4674 N GLU c 202 6.004 -44. ,766 3. .580 1. .00 26. .12 N

ANISOU 4674 N GLU c 202 2743 3053 4128 -189 676 1439 N

ATOM 4675 CA GLU c 202 6.962 -44. ,752 2. .478 1. .00 27. .67 C

ANISOU 4675 CA GLU c 202 3670 2716 4125 -146 1130 1740 C

ATOM 4676 C GLU c 202 7.052 -43. ,353 1. .865 1. .00 24. .22 C

ANISOU 4676 C GLU c 202 3502 2502 3198 -41 704 1329 C

ATOM 4677 O GLU c 202 6.218 -42. ,484 2. .140 1. .00 24. .46 O

ANISOU 4677 O GLU c 202 2831 3028 3434 -47 711 1345 O

ATOM 4678 CB GLU c 202 6.575 -45. ,792 1. .415 1. .00 32. .93 C

ANISOU 4678 CB GLU c 202 3608 3706 5194 194 1369 878 C

ATOM 4679 CG GLU c 202 6.415 -47. ,221 1. .939 1. .00 37. .93 c

ANISOU 4679 CG GLU c 202 4324 3868 6216 756 1797 1272 c

ATOM 4680 CD GLU c 202 7.729 -47. ,982 2. .048 1. .00 52. .62 c

ANISOU 4680 CD GLU c 202 5521 6045 8425 2234 1151 163 c

ATOM 4681 OE1 GLU c 202 8.642 -47. ,754 1. .224 1. .00 54. .30 0

ANISOU 4681 OE1 GLU c 202 5055 6974 8603 757 613 672 0

ATOM 4682 OE2 GLU c 202 7.851 -48. ,828 2. .959 1. .00 60. .54 0

ANISOU 4682 OE2 GLU c 202 7607 7325 8068 498 468 393 0

ATOM 4683 N TRP c 203 8.075 -43. ,146 1. .040 1. .00 21. .49 N

ANISOU 4683 N TRP c 203 2485 2688 2990 -128 52 1015 N

ATOM 4684 CA TRP c 203 8.299 -41. ,880 0. .358 1. .00 21. .04 C

ANISOU 4684 CA TRP c 203 2253 2491 3249 -102 -186 981 C

ATOM 4685 C TRP c 203 7.608 -41. ,852 -0. .951 1. .00 21. .34 C

ANISOU 4685 C TRP c 203 2083 2840 3185 53 -22 1103 C ATOM 4686 O TRP C 203 7.610 -42..846 -1..691 1..00 23..94 O

ANISOU 4686 O TRP C 203 2352 2970 3774 321 -505 969 O

ATOM 4687 CB TRP C 203 9.784 -41. .664 0. .109 1. .00 21. .76 C

ANISOU 4687 CB TRP C 203 2102 3102 3064 84 -366 894 C

ATOM 4688 CG TRP C 203 10.468 -41. .136 1. .337 1. .00 21. .79 C

ANISOU 4688 CG TRP C 203 2158 3060 3058 -374 -64 703 C

ATOM 4689 CD1 TRP C 203 11.184 -41. .852 2. .289 1. .00 23. .00 C

ANISOU 4689 CD1 TRP C 203 2033 3242 3462 -251 -233 675 C

ATOM 4690 CD2 TRP C 203 10.456 -39. .756 1. .818 1. .00 20. .82 C

ANISOU 4690 CD2 TRP C 203 1687 3117 3106 49 159 846 C

ATOM 4691 NE1 TRP C 203 11.629 -41. .024 3. .285 1. .00 23. .66 N

ANISOU 4691 NE1 TRP C 203 2547 3259 3182 -86 -293 787 N

ATOM 4692 CE2 TRP C 203 11.227 -39. .749 3. .060 1. .00 23. .39 C

ANISOU 4692 CE2 TRP C 203 2328 3299 3261 -258 -168 1048 C

ATOM 4693 CE3 TRP C 203 9.932 -38. .559 1. .341 1. .00 21. .10 C

ANISOU 4693 CE3 TRP C 203 1946 2857 3212 60 805 868 C

ATOM 4694 CZ2 TRP C 203 11.431 -38. .583 3. .792 1. .00 21. .77 C

ANISOU 4694 CZ2 TRP C 203 1823 2925 3521 105 307 1088 C

ATOM 4695 CZ3 TRP C 203 10.149 -37. .393 2. .082 1. .00 20. .94 C

ANISOU 4695 CZ3 TRP C 203 1505 3365 3084 9 152 703 C

ATOM 4696 CH2 TRP C 203 10.878 -37. .407 3. .280 1. .00 21. .54 C

ANISOU 4696 CH2 TRP C 203 1753 3385 3042 178 72 1254 c

ATOM 4697 N SER C 204 7.025 -40. .701 -1. .260 1. .00 19. .42 N

ANISOU 4697 N SER c 204 2094 2820 2462 128 -16 910 N

ATOM 4698 CA SER c 204 6.501 -40. .454 -2. .585 1. .00 18. .96 C

ANISOU 4698 CA SER c 204 2494 2247 2460 96 -19 1035 C

ATOM 4699 C SER c 204 6.654 -38. .973 -2. .905 1. .00 18. .40 C

ANISOU 4699 C SER c 204 2370 2210 2409 102 -67 918 C

ATOM 4700 O SER c 204 7.463 -38. .281 -2. .286 1. .00 18. .53 O

ANISOU 4700 O SER c 204 1635 3046 2358 550 -238 800 O

ATOM 4701 CB SER c 204 5.043 -40. .908 -2. .688 1. .00 18. .78 C

ANISOU 4701 CB SER c 204 2560 2192 2381 -22 -210 554 c

ATOM 4702 OG SER c 204 4.643 -40. .948 -4. .042 1. .00 20. .00 0

ANISOU 4702 OG SER c 204 2635 2708 2255 -226 104 623 0

ATOM 4703 N LYS c 205 5.878 -38. .469 -3. .859 1. .00 16. .79 N

ANISOU 4703 N LYS c 205 1861 2380 2136 355 148 542 N

ATOM 4704 CA LYS c 205 6.045 -37. .082 -4. .257 1. .00 16. .74 C

ANISOU 4704 CA LYS c 205 1666 2404 2290 379 284 586 C

ATOM 4705 C LYS c 205 4.814 -36. .546 -4. .960 1. .00 15. .15 C

ANISOU 4705 C LYS c 205 1700 2324 1730 298 176 281 C

ATOM 4706 O LYS c 205 4.042 -37. .309 -5. .554 1. .00 16. .78 O

ANISOU 4706 O LYS c 205 1832 2432 2111 -22 243 471 O

ATOM 4707 CB LYS c 205 7.277 -36. .906 -5. .161 1. .00 16. .55 c

ANISOU 4707 CB LYS c 205 1541 2136 2610 319 378 106 c

ATOM 4708 CG LYS c 205 7.151 -37. .558 -6. .517 1. .00 18. .27 c

ANISOU 4708 CG LYS c 205 1696 2682 2565 460 480 -8 c

ATOM 4709 CD LYS c 205 8.390 -37. .307 -7. .360 1. .00 22. .78 c

ANISOU 4709 CD LYS c 205 2723 2781 3150 -374 1290 -405 c

ATOM 4710 CE LYS c 205 8.258 -37. .966 -8. .721 1. .00 28. .86 c

ANISOU 4710 CE LYS c 205 3217 4002 3743 -261 1092 - 1240 c

ATOM 4711 NZ LYS c 205 9.303 -37. .463 -9. .658 1. .00 36. .90 N

ANISOU 4711 NZ LYS c 205 5258 5079 3683 -1293 1523 - 1132 N

ATOM 4712 N THR c 206 4.641 -35. .232 -4. .874 1. .00 14. .84 N

ANISOU 4712 N THR c 206 1292 2209 2135 31 -63 470 N

ATOM 4713 CA THR c 206 3.597 -34. .531 -5. .605 1. .00 12. .06 C

ANISOU 4713 CA THR c 206 1462 1703 1416 -72 6 292 C

ATOM 4714 C THR c 206 4.269 -33. .376 -6. .341 1. .00 12. .54 C

ANISOU 4714 C THR c 206 1574 1744 1444 -170 26 237 C

ATOM 4715 O THR c 206 5.145 -32. .707 -5. .778 1. .00 13. .86 O

ANISOU 4715 O THR c 206 1118 2253 1895 -33 -109 167 O

ATOM 4716 CB THR c 206 2.519 -34. .011 -4. .631 1. .00 12. .00 C ANISOU 4716 CB THR C 206 1122 1853 1584 -118 -10 387 C

ATOM 4717 OG1 THR C 206 1.932 -35. .128 -3. .951 1. .00 15. .43 O

ANISOU 4717 OG1 THR C 206 2244 1879 1740 -465 74 330 O

ATOM 4718 CG2 THR C 206 1.402 -33. .229 -5. .344 1. .00 13. .22 C

ANISOU 4718 CG2 THR C 206 1468 2034 1521 39 - 243 328 C

ATOM 4719 N VAL C 207 3.846 -33. .152 -7. .592 1. .00 11. .40 N

ANISOU 4719 N VAL C 207 1373 1623 1334 -172 161 285 N

ATOM 4720 CA VAL C 207 4.450 -32. .143 -8. .443 1. .00 11. .73 C

ANISOU 4720 CA VAL C 207 1426 1827 1201 25 283 438 C

ATOM 4721 C VAL C 207 3.447 -31. .055 -8. .734 1. .00 12. .92 C

ANISOU 4721 C VAL C 207 1500 2006 1402 1 76 449 C

ATOM 4722 O VAL C 207 2.329 -31. .336 -9. .199 1. .00 14. .61 O

ANISOU 4722 O VAL C 207 1479 2283 1786 -225 133 -13 O

ATOM 4723 CB VAL C 207 4.969 -32. .742 -9. .769 1. .00 14. .37 C

ANISOU 4723 CB VAL C 207 1959 1960 1539 28 464 148 C

ATOM 4724 CGI VAL C 207 5.596 -31. .644 -10. .633 1. .00 15. .98 C

ANISOU 4724 CGI VAL C 207 2242 1798 2029 -100 155 352 c

ATOM 4725 CG2 VAL C 207 5.985 -33. .836 -9. .466 1. .00 17. .81 c

ANISOU 4725 CG2 VAL C 207 2194 2274 2296 273 301 125 c

ATOM 4726 N PHE C 208 3.869 -29. .820 -8. .463 1. .00 13. .84 N

ANISOU 4726 N PHE C 208 1686 1857 1716 216 34 261 N

ATOM 4727 CA PHE C 208 3.048 -28. .628 -8. .632 1. .00 13. .60 C

ANISOU 4727 CA PHE c 208 1798 1867 1499 247 - 122 191 C

ATOM 4728 C PHE c 208 3.620 -27. .749 -9. .725 1. .00 14. .41 C

ANISOU 4728 C PHE c 208 1649 2330 1495 176 - 232 322 C

ATOM 4729 O PHE c 208 4.839 -27. .694 -9. .906 1. .00 15. .58 O

ANISOU 4729 O PHE c 208 1712 2504 1703 -41 10 392 O

ATOM 4730 CB PHE c 208 3.067 -27. .815 -7. .329 1. .00 13. .75 c

ANISOU 4730 CB PHE c 208 1765 2230 1229 134 - 126 251 c

ATOM 4731 CG PHE c 208 2.541 -28. .553 -6. .139 1. .00 11. .33 c

ANISOU 4731 CG PHE c 208 1245 1636 1423 59 - 230 235 c

ATOM 4732 CD1 PHE c 208 3.382 -29. .388 -5. .395 1. .00 11. .83 c

ANISOU 4732 CD1 PHE c 208 1901 1456 1138 141 - 301 203 c

ATOM 4733 CD2 PHE c 208 1.202 -28. .402 -5. .741 1. .00 11. .90 c

ANISOU 4733 CD2 PHE c 208 1446 1793 1280 -168 92 214 c

ATOM 4734 CE1 PHE c 208 2.896 -30. .082 -4. .294 1. .00 13. .59 c

ANISOU 4734 CE1 PHE c 208 1697 2030 1436 -62 71 236 c

ATOM 4735 CE2 PHE c 208 0.715 -29. .082 -4. .629 1. .00 12. .15 c

ANISOU 4735 CE2 PHE c 208 1448 1927 1241 -278 - 165 369 c

ATOM 4736 CZ PHE c 208 1.573 -29. .910 -3. .896 1. .00 13. .22 c

ANISOU 4736 CZ PHE c 208 1543 1688 1790 -73 -51 407 c

ATOM 4737 N GLU c 209 2.739 -27. .034 -10. .421 1. .00 12. .02 N

ANISOU 4737 N GLU c 209 1504 1605 1457 147 - 142 66 N

ATOM 4738 CA GLU c 209 3.127 -26. .072 -11. .440 1. .00 13. .19 C

ANISOU 4738 CA GLU c 209 1652 1747 1611 -23 51 65 c

ATOM 4739 C GLU c 209 2.331 -24. .786 -11. .271 1. .00 14. .80 c

ANISOU 4739 C GLU c 209 1687 1926 2009 56 292 215 c

ATOM 4740 O GLU c 209 1.127 -24. .820 -11. .010 1. .00 14. .62 0

ANISOU 4740 O GLU c 209 1585 2301 1667 179 163 312 0

ATOM 4741 CB GLU c 209 2.859 -26. .637 -12. .835 1. .00 15. .95 c

ANISOU 4741 CB GLU c 209 2203 2526 1330 8 -98 392 c

ATOM 4742 CG GLU c 209 3.440 -25. .804 -13. .969 1. .00 18. .71 c

ANISOU 4742 CG GLU c 209 2527 3166 1413 59 142 484 c

ATOM 4743 CD GLU c 209 3.054 -26. .390 -15. .299 1. .00 27. .22 c

ANISOU 4743 CD GLU c 209 3843 5108 1387 442 - 143 150 c

ATOM 4744 OE1 GLU c 209 1.876 -26. .252 -15. .682 1. .00 30. .99 0

ANISOU 4744 OE1 GLU c 209 3549 5817 2408 -515 - 174 225 0

ATOM 4745 OE2 GLU c 209 3.919 -27. .001 -15. .946 1. .00 37. .05 0

ANISOU 4745 OE2 GLU c 209 4795 6281 3002 315 1064 -569 0

ATOM 4746 N TYR c 210 2.990 -23. .653 -11. .440 1. .00 13. .67 N

ANISOU 4746 N TYR c 210 1491 1644 2056 166 151 -68 N ATOM 4747 CA TYR C 210 2.264 -22.,405 -11..596 1..00 14..52 C

ANISOU 4747 CA TYR C 210 1350 1673 2492 81 255 282 C

ATOM 4748 C TYR C 210 2.725 -21. ,753 -12. .887 1. .00 15. .96 C

ANISOU 4748 C TYR C 210 1671 2044 2348 34 136 321 C

ATOM 4749 O TYR C 210 3.923 -21. ,695 -13. .154 1. .00 15. .35 O

ANISOU 4749 O TYR C 210 1578 1990 2263 306 120 432 O

ATOM 4750 CB TYR C 210 2.451 -21. ,476 -10. .402 1. .00 14. .60 C

ANISOU 4750 CB TYR C 210 1317 1855 2373 213 446 229 C

ATOM 4751 CG TYR C 210 1.587 -20. ,223 -10. .516 1. .00 16. .97 C

ANISOU 4751 CG TYR C 210 2057 1719 2672 305 159 432 C

ATOM 4752 CD1 TYR C 210 0.197 -20. ,289 -10. .369 1. .00 19. .40 C

ANISOU 4752 CD1 TYR C 210 2171 2362 2836 123 330 434 C

ATOM 4753 CD2 TYR C 210 2.166 -18. ,972 -10. .788 1. .00 16. .61 C

ANISOU 4753 CD2 TYR C 210 2124 2079 2109 -135 478 220 C

ATOM 4754 CE1 TYR C 210 -0.593 -19. ,147 -10. .490 1. .00 19. .53 C

ANISOU 4754 CE1 TYR C 210 2116 2712 2591 415 61 424 C

ATOM 4755 CE2 TYR C 210 1.393 -17. ,831 -10. .912 1. .00 16. .20 C

ANISOU 4755 CE2 TYR C 210 1997 2257 1899 -92 827 151 C

ATOM 4756 CZ TYR C 210 0.018 -17. ,914 -10. .758 1. .00 20. .21 C

ANISOU 4756 CZ TYR C 210 1799 2709 3170 379 294 148 C

ATOM 4757 OH TYR C 210 -0.734 -16. ,766 -10. .883 1. .00 21. .24 O

ANISOU 4757 OH TYR C 210 2306 2794 2970 622 746 425 O

ATOM 4758 N ARG C 211 1.766 -21. ,308 -13. .698 1. .00 16. .85 N

ANISOU 4758 N ARG C 211 1491 2343 2566 241 79 129 N

ATOM 4759 CA ARG C 211 2.038 -20. ,688 -14. .991 1. .00 18. .14 C

ANISOU 4759 CA ARG C 211 1402 2707 2781 -24 -86 422 C

ATOM 4760 C ARG c 211 1.118 -19. ,487 -15. .105 1. .00 20. .04 C

ANISOU 4760 C ARG c 211 2170 2282 3162 -162 -361 532 C

ATOM 4761 O ARG c 211 -0.061 -19. ,563 -14. .741 1. .00 21. .22 O

ANISOU 4761 O ARG c 211 2380 2678 3002 95 -164 1013 O

ATOM 4762 CB ARG c 211 1.782 -21. ,689 -16. .125 1. .00 20. .02 C

ANISOU 4762 CB ARG c 211 1269 3652 2686 -341 122 146 C

ATOM 4763 CG ARG c 211 2.094 -21. ,180 -17. .533 1. .00 25. .79 c

ANISOU 4763 CG ARG c 211 2892 4211 2697 -21 -376 479 c

ATOM 4764 CD ARG c 211 1.825 -22. ,222 -18. .618 1. .00 30. .08 c

ANISOU 4764 CD ARG c 211 2183 5573 3672 629 -1010 -791 c

ATOM 4765 NE ARG c 211 2.442 -23. ,523 -18. .322 1. .00 41. .88 N

ANISOU 4765 NE ARG c 211 4706 5685 5522 361 -742 530 N

ATOM 4766 CZ ARG c 211 3.603 -23. ,951 -18. .819 1. .00 38. .87 C

ANISOU 4766 CZ ARG c 211 5380 5863 3525 -76 177 771 C

ATOM 4767 NH1 ARG c 211 4.310 -23. ,196 -19. .660 1. .00 41. .32 N

ANISOU 4767 NH1 ARG c 211 6259 6764 2674 -2771 -921 -61 N

ATOM 4768 NH2 ARG c 211 4.060 -25. ,146 -18. .475 1. .00 39. .64 N

ANISOU 4768 NH2 ARG c 211 6101 5548 3409 -521 223 751 N

ATOM 4769 N THR c 212 1.663 -18. ,377 -15. .600 1. .00 20. .90 N

ANISOU 4769 N THR c 212 2228 2583 3127 72 43 938 N

ATOM 4770 CA THR c 212 0.950 -17. ,111 -15. .616 1. .00 18. .88 C

ANISOU 4770 CA THR c 212 1469 2875 2828 113 25 885 C

ATOM 4771 C THR c 212 1.484 -16. ,154 -16. .679 1. .00 20. .43 C

ANISOU 4771 C THR c 212 1871 3091 2799 753 6 1330 C

ATOM 4772 O THR c 212 2.651 -16. ,232 -17. .072 1. .00 22. .84 O

ANISOU 4772 O THR c 212 2110 3283 3284 299 481 1272 O

ATOM 4773 CB THR c 212 0.984 -16. ,427 -14. .220 1. .00 20. .50 C

ANISOU 4773 CB THR c 212 1615 3094 3080 -161 257 555 C

ATOM 4774 OG1 THR c 212 0.201 -15. ,233 -14. .246 1. .00 23. .04 O

ANISOU 4774 OG1 THR c 212 2232 3558 2963 462 -7 541 O

ATOM 4775 CG2 THR c 212 2.403 -16. ,084 -13. .773 1. .00 20. .11 C

ANISOU 4775 CG2 THR c 212 1150 3896 2595 194 625 808 C

ATOM 4776 N ARG c 213 0.618 -15. ,250 -17. .135 1. .00 19. .04 N

ANISOU 4776 N ARG c 213 1121 3085 3028 711 574 1383 N

ATOM 4777 CA ARG c 213 1.063 -14. ,112 -17. .920 1. .00 20. .56 C ANISOU 4777 CA ARG C 213 1795 3154 2860 574 -81 1541 C

ATOM 4778 C ARG c 213 1.604 -12. .996 -17. .033 1. .00 22. .85 C

ANISOU 4778 C ARG c 213 2306 3351 3023 284 20 1382 C

ATOM 4779 O ARG c 213 2.281 -12. .087 -17. .517 1. .00 26. .14 O

ANISOU 4779 O ARG c 213 1606 4305 4020 -73 418 1373 O

ATOM 4780 CB ARG c 213 -0.088 -13. .537 -18. .720 1. .00 24. .33 C

ANISOU 4780 CB ARG c 213 2149 4154 2939 635 -380 1678 C

ATOM 4781 CG ARG c 213 -0.458 -14. .297 -19. .968 1. .00 23. .35 C

ANISOU 4781 CG ARG c 213 1112 4459 3298 1115 -781 1202 C

ATOM 4782 CD ARG c 213 -1.691 -13. .610 -20. .528 1. .00 24. .90 C

ANISOU 4782 CD ARG c 213 2342 4101 3017 1436 -1009 1401 C

ATOM 4783 NE ARG c 213 -2.211 -14. .238 -21. .736 1. .00 33. .93 N

ANISOU 4783 NE ARG c 213 3379 5918 3593 -223 -973 871 N

ATOM 4784 CZ ARG c 213 -1.780 -13. .986 -22. .969 1. .00 42. .51 C

ANISOU 4784 CZ ARG c 213 5663 6880 3608 -147 -656 283 C

ATOM 4785 NH1 ARG c 213 -0.788 -13. .124 -23. .184 1. .00 41. .78 N

ANISOU 4785 NH1 ARG c 213 4267 7382 4225 409 -616 971 N

ATOM 4786 NH2 ARG c 213 -2.343 -14. .608 -23. .995 1. .00 49. .35 N

ANISOU 4786 NH2 ARG c 213 6256 7920 4575 1671 -1799 -930 N

ATOM 4787 N LYS c 214 1.271 -13. .042 -15. .749 1. .00 20. .72 N

ANISOU 4787 N LYS c 214 1725 3058 3089 -58 211 837 N

ATOM 4788 CA LYS c 214 1.688 -12. .001 -14. .832 1. .00 23. .58 C

ANISOU 4788 CA LYS c 214 2045 3300 3612 97 -3 604 C

ATOM 4789 C LYS c 214 3.019 -12. .442 -14. .210 1. .00 21. .79 C

ANISOU 4789 C LYS c 214 2114 2718 3447 140 -9 399 C

ATOM 4790 O LYS c 214 3.082 -12. .868 -13. .057 1. .00 22. .19 O

ANISOU 4790 O LYS c 214 1527 3118 3786 -206 664 816 O

ATOM 4791 CB LYS c 214 0.597 -11. .715 -13. .789 1. .00 23. .96 C

ANISOU 4791 CB LYS c 214 2553 2920 3628 -21 73 406 C

ATOM 4792 CG LYS c 214 -0.754 -11. .294 -14. .373 1. .00 26. .51 C

ANISOU 4792 CG LYS c 214 3051 2787 4236 265 -163 601 C

ATOM 4793 CD LYS c 214 -0.710 -9. .913 -15. .006 1. .00 29. .77 C

ANISOU 4793 CD LYS c 214 3821 3166 4323 718 -514 1044 C

ATOM 4794 CE LYS c 214 -1.979 -9. .667 -15. .818 1. .00 31. .31 C

ANISOU 4794 CE LYS c 214 3533 3534 4827 1364 -310 973 C

ATOM 4795 NZ LYS c 214 -2.004 -8. .279 -16. .349 1. .00 36. .23 N

ANISOU 4795 NZ LYS c 214 5070 3268 5427 692 245 549 N

ATOM 4796 N ALA c 215 4.083 -12. .331 -15. .001 1. .00 19. .47 N

ANISOU 4796 N ALA c 215 1639 1854 3903 -19 -161 210 N

ATOM 4797 CA ALA c 215 5.390 -12. .884 -14. .615 1. .00 19. .96 C

ANISOU 4797 CA ALA c 215 1660 2469 3452 195 90 329 C

ATOM 4798 C ALA c 215 5.989 -12. .268 -13. .343 1. .00 20. .62 C

ANISOU 4798 C ALA c 215 1939 2538 3357 351 305 268 C

ATOM 4799 O ALA c 215 6.907 -12. .849 -12. .754 1. .00 18. .57 O

ANISOU 4799 O ALA c 215 1714 2004 3335 44 370 558 O

ATOM 4800 CB ALA c 215 6.373 -12. .811 -15. .775 1. .00 19. .96 C

ANISOU 4800 CB ALA c 215 2152 2387 3045 77 136 68 C

ATOM 4801 N VAL c 216 5.466 -11. .114 -12. .913 1. .00 18. .66 N

ANISOU 4801 N VAL c 216 1924 1719 3445 -403 671 463 N

ATOM 4802 CA VAL c 216 5.887 -10. .523 -11. .632 1. .00 21. .33 C

ANISOU 4802 CA VAL c 216 1990 2404 3707 -275 436 373 C

ATOM 4803 C VAL c 216 5.678 -11. .467 -10. .452 1. .00 20. .46 C

ANISOU 4803 C VAL c 216 2003 1997 3773 41 371 269 C

ATOM 4804 O VAL c 216 6.341 -11. .336 -9. .422 1. .00 22. .06 O

ANISOU 4804 O VAL c 216 2635 2056 3689 -383 291 556 O

ATOM 4805 CB VAL c 216 5.219 -9. .160 -11. .333 1. .00 24. .36 C

ANISOU 4805 CB VAL c 216 1776 2865 4613 409 600 828 C

ATOM 4806 CGI VAL c 216 5.891 -8. .049 -12. .139 1. .00 28. .87 C

ANISOU 4806 CGI VAL c 216 2505 3190 5271 534 773 1334 c

ATOM 4807 CG2 VAL c 216 3.710 -9. .201 -11. .587 1. .00 26. .26 c

ANISOU 4807 CG2 VAL c 216 1941 3390 4645 746 223 289 c ATOM 4808 N ARG C 217 4.763 -12..425 -10..624 1..00 22..25 N

ANISOU 4808 N ARG C 217 2469 2040 3943 -308 714 237 N

ATOM 4809 CA ARG C 217 4.416 -13. .401 -9. .587 1. .00 21. .55 C

ANISOU 4809 CA ARG C 217 2121 2306 3757 Ill 778 324 C

ATOM 4810 C ARG C 217 5.469 -14. .483 -9. .387 1. .00 19. .47 C

ANISOU 4810 C ARG C 217 2064 2242 3090 -48 322 263 C

ATOM 4811 O ARG C 217 5.501 -15. .125 -8. .339 1. .00 19. .20 O

ANISOU 4811 O ARG C 217 1767 2477 3049 22 1024 398 O

ATOM 4812 CB ARG C 217 3.076 -14. .060 -9. .917 1. .00 19. .87 C

ANISOU 4812 CB ARG C 217 1216 2482 3850 928 801 410 C

ATOM 4813 CG ARG C 217 1.915 -13. .077 -9. .873 1. .00 19. .80 C

ANISOU 4813 CG ARG C 217 1142 1962 4416 654 1013 732 C

ATOM 4814 CD ARG C 217 0.646 -13. .743 -10. .325 1. .00 24. .94 C

ANISOU 4814 CD ARG C 217 1421 3241 4813 296 799 449 C

ATOM 4815 NE ARG C 217 -0.444 -12. .783 -10. .329 1. .00 24. .99 N

ANISOU 4815 NE ARG C 217 2002 3213 4279 607 989 801 N

ATOM 4816 CZ ARG C 217 -1.560 -12. .928 -11. .037 1. .00 25. .68 C

ANISOU 4816 CZ ARG C 217 1445 3926 4384 655 1447 427 C

ATOM 4817 NH1 ARG C 217 -1.730 -13. .994 -11. .818 1. .00 28. .56 N

ANISOU 4817 NH1 ARG C 217 2191 3314 5346 205 703 688 N

ATOM 4818 NH2 ARG C 217 -2.486 -11. .998 -10. .979 1. .00 29. .26 N

ANISOU 4818 NH2 ARG C 217 2999 3365 4753 1313 661 1074 N

ATOM 4819 N LEU c 218 6.325 -14. .685 -10. .391 1. .00 18. .12 N

ANISOU 4819 N LEU c 218 1539 2086 3259 32 145 212 N

ATOM 4820 CA LEU c 218 7.330 -15. .737 -10. .330 1. .00 16. .49 C

ANISOU 4820 CA LEU c 218 1829 1749 2685 51 251 94 C

ATOM 4821 C LEU c 218 8.743 -15. .142 -10. .272 1. .00 15. .26 C

ANISOU 4821 C LEU c 218 1848 1634 2315 60 -303 48 C

ATOM 4822 O LEU c 218 8.958 -14. .025 -10. .741 1. .00 18. .12 O

ANISOU 4822 O LEU c 218 2215 1711 2957 -151 171 73 O

ATOM 4823 CB LEU c 218 7.163 -16. .711 -11. .507 1. .00 14. .49 C

ANISOU 4823 CB LEU c 218 1508 1851 2144 2 -86 374 C

ATOM 4824 CG LEU c 218 5.975 -17. .685 -11. .414 1. .00 15. .37 C

ANISOU 4824 CG LEU c 218 2026 1479 2335 -86 355 84 C

ATOM 4825 CD1 LEU c 218 5.770 -18. .430 -12. .721 1. .00 15. .25 C

ANISOU 4825 CD1 LEU c 218 1517 2393 1883 -274 -93 344 C

ATOM 4826 CD2 LEU c 218 6.153 -18. .676 -10. .259 1. .00 15. .35 C

ANISOU 4826 CD2 LEU c 218 1492 1922 2416 -78 256 300 C

ATOM 4827 N PRO c 219 9.725 -15. .888 -9. .717 1. .00 16. .13 N

ANISOU 4827 N PRO c 219 1783 2015 2330 22 -328 231 N

ATOM 4828 CA PRO c 219 9.662 -17. .269 -9. .243 1. .00 15. .51 C

ANISOU 4828 CA PRO c 219 1687 2037 2168 -46 70 168 C

ATOM 4829 C PRO c 219 9.041 -17. .478 -7. .855 1. .00 15. .02 C

ANISOU 4829 C PRO c 219 1527 2122 2057 -76 21 22 C

ATOM 4830 O PRO c 219 8.749 -16. .512 -7. .130 1. .00 16. .53 O

ANISOU 4830 O PRO c 219 2292 1891 2094 -346 302 70 O

ATOM 4831 CB PRO c 219 11.139 -17. .685 -9. .193 1. .00 15. .19 C

ANISOU 4831 CB PRO c 219 1567 2271 1934 -224 -113 66 C

ATOM 4832 CG PRO c 219 11.843 -16. .417 -8. .851 1. .00 15. .49 C

ANISOU 4832 CG PRO c 219 1901 1820 2162 3 -386 373 c

ATOM 4833 CD PRO c 219 11.095 -15. .337 -9. .612 1. .00 14. .52 c

ANISOU 4833 CD PRO c 219 1747 1847 1922 27 -233 408 c

ATOM 4834 N ILE c 220 8.847 -18. .755 -7. .523 1. .00 15. .23 N

ANISOU 4834 N ILE c 220 1607 2327 1849 -235 185 283 N

ATOM 4835 CA ILE c 220 8.444 -19. .202 -6. .200 1. .00 14. .94 C

ANISOU 4835 CA ILE c 220 1643 2076 1957 -439 405 164 C

ATOM 4836 C ILE c 220 9.580 -18. .975 -5. .214 1. .00 16. .74 C

ANISOU 4836 C ILE c 220 2167 2158 2037 -631 322 -246 C

ATOM 4837 O ILE c 220 10.707 -19. .378 -5. .468 1. .00 17. .83 O

ANISOU 4837 O ILE c 220 1887 2641 2247 -647 90 -187 O

ATOM 4838 CB ILE c 220 8.108 -20. .705 -6. .236 1. .00 14. .45 c ANISOU 4838 CB ILE C 220 1717 2069 1702 -509 385 288 C

ATOM 4839 CGI ILE C 220 6.887 -20. .946 -7. .142 1. .00 17. .05 C

ANISOU 4839 CGI ILE c 220 2198 2101 2178 -303 -51 63 C

ATOM 4840 CG2 ILE c 220 7.861 -21. .239 -4. .816 1. .00 15. .23 C

ANISOU 4840 CG2 ILE c 220 1943 2108 1733 -328 369 404 C

ATOM 4841 CD1 ILE c 220 6.691 -22. .390 -7. .556 1. .00 15. .80 C

ANISOU 4841 CD1 ILE c 220 1752 2124 2127 -528 552 30 C

ATOM 4842 N VAL c 221 9.284 -18. .350 -4. .081 1. .00 17. .30 N

ANISOU 4842 N VAL c 221 2148 2371 2054 -827 403 -401 N

ATOM 4843 CA VAL c 221 10.330 -18. .088 -3. .085 1. .00 19. .25 C

ANISOU 4843 CA VAL c 221 2467 2848 1998 -768 263 -458 C

ATOM 4844 C VAL c 221 10.209 -18. .888 -1. .777 1. .00 19. .57 C

ANISOU 4844 C VAL c 221 2455 2897 2083 -894 - 272 -303 C

ATOM 4845 O VAL c 221 11.145 -18. .917 -0. .980 1. .00 17. .14 O

ANISOU 4845 O VAL c 221 1719 2907 1883 -824 162 -20 O

ATOM 4846 CB VAL c 221 10.463 -16. .578 -2. .780 1. .00 22. .91 C

ANISOU 4846 CB VAL c 221 3191 2732 2781 -660 -79 -252 C

ATOM 4847 CGI VAL c 221 10.730 -15. .787 -4. .058 1. .00 24. .06 c

ANISOU 4847 CGI VAL c 221 3245 2796 3101 -674 191 -18 c

ATOM 4848 CG2 VAL c 221 9.236 -16. .058 -2. .061 1. .00 22. .94 c

ANISOU 4848 CG2 VAL c 221 3077 2991 2646 -885 -60 -529 c

ATOM 4849 N ASP c 222 9.056 -19. .512 -1. .543 1. .00 16. .76 N

ANISOU 4849 N ASP c 222 2174 2379 1813 -547 -12 -334 N

ATOM 4850 CA ASP c 222 8.828 -20. .279 -0. .308 1. .00 18. .28 C

ANISOU 4850 CA ASP c 222 2544 2880 1521 -583 - 126 -355 C

ATOM 4851 C ASP c 222 7.713 -21. .298 -0. .481 1. .00 18. .27 C

ANISOU 4851 C ASP c 222 2471 2348 2123 -368 261 -338 C

ATOM 4852 O ASP c 222 6.993 -21. .283 -1. .481 1. .00 17. .85 O

ANISOU 4852 O ASP c 222 2224 2569 1988 -853 498 -571 O

ATOM 4853 CB ASP c 222 8.476 -19. .346 0. .862 1. .00 19. .16 c

ANISOU 4853 CB ASP c 222 2589 2917 1772 -674 135 -485 c

ATOM 4854 CG ASP c 222 9.030 -19. .838 2. .219 1. .00 22. .28 c

ANISOU 4854 CG ASP c 222 3512 2893 2058 -378 2 -176 c

ATOM 4855 OD1 ASP c 222 9.331 -21. .048 2. .382 1. .00 19. .03 0

ANISOU 4855 OD1 ASP c 222 2377 3217 1633 -346 - 100 55 0

ATOM 4856 OD2 ASP c 222 9.145 -19. .001 3. .143 1. .00 23. .70 0

ANISOU 4856 OD2 ASP c 222 3198 3707 2100 -1248 -95 -388 0

ATOM 4857 N ILE c 223 7.564 -22. .163 0. .519 1. .00 18. .36 N

ANISOU 4857 N ILE c 223 2100 2689 2186 -609 231 -302 N

ATOM 4858 CA ILE c 223 6.596 -23. .275 0. .475 1. .00 17. .63 C

ANISOU 4858 CA ILE c 223 2482 2264 1952 -524 338 279 C

ATOM 4859 C ILE c 223 6.093 -23. .491 1. .882 1. .00 17. .95 C

ANISOU 4859 C ILE c 223 1779 3132 1907 -604 337 -51 C

ATOM 4860 O ILE c 223 6.881 -23. .435 2. .846 1. .00 19. .02 0

ANISOU 4860 O ILE c 223 2635 2901 1688 -767 172 156 0

ATOM 4861 CB ILE c 223 7.229 -24. .557 -0. .132 1. .00 18. .56 c

ANISOU 4861 CB ILE c 223 2436 2536 2078 -334 -80 -90 c

ATOM 4862 CGI ILE c 223 6.202 -25. .696 -0. .269 1. .00 16. .54 c

ANISOU 4862 CGI ILE c 223 2433 1970 1878 -77 428 -128 c

ATOM 4863 CG2 ILE c 223 8.487 -24. .986 0. .634 1. .00 17. .27 c

ANISOU 4863 CG2 ILE c 223 1960 2792 1809 -435 187 -319 c

ATOM 4864 CD1 ILE c 223 6.636 -26. .795 -1. .239 1. .00 15. .78 c

ANISOU 4864 CD1 ILE c 223 1922 2102 1969 395 - 352 -289 c

ATOM 4865 N ALA c 224 4.785 -23. .706 1. .999 1. .00 15. .70 N

ANISOU 4865 N ALA c 224 1768 2682 1514 -577 464 -206 N

ATOM 4866 CA ALA c 224 4.154 -23. .905 3. .301 1. .00 17. .21 C

ANISOU 4866 CA ALA c 224 2120 2874 1543 -712 597 -450 C

ATOM 4867 C ALA c 224 3.336 -25. .191 3. .289 1. .00 17. .28 C

ANISOU 4867 C ALA c 224 2023 2741 1799 -566 76 -92 c

ATOM 4868 O ALA c 224 2.202 -25. .186 2. .834 1. .00 18. .24 0

ANISOU 4868 O ALA c 224 1801 3354 1775 -147 219 -331 0 ATOM 4869 CB ALA C 224 3.275 -22.,712 3..659 1..00 18..25 C

ANISOU 4869 CB ALA C 224 1481 3288 2163 -442 291 ^■431 C

ATOM 4870 N PRO C 225 3.910 -26. ,303 3. .786 1. .00 17. .87 N

ANISOU 4870 N PRO C 225 2550 2663 1575 -579 -33 -50 N

ATOM 4871 CA PRO C 225 3.094 -27. ,497 3. .980 1. .00 15. .31 C

ANISOU 4871 CA PRO C 225 2153 2640 1022 -371 230 ^■150 C

ATOM 4872 C PRO C 225 2.123 -27. ,281 5. .135 1. .00 18. .39 C

ANISOU 4872 C PRO C 225 2736 3308 942 -704 432 ^■314 C

ATOM 4873 O PRO C 225 2.317 -26. ,359 5. .950 1. .00 19. .95 O

ANISOU 4873 O PRO C 225 3073 3091 1413 -678 279 ^■362 O

ATOM 4874 CB PRO C 225 4.128 -28. ,584 4. .337 1. .00 16. .78 C

ANISOU 4874 CB PRO C 225 2084 2790 1500 -315 513 72 C

ATOM 4875 CG PRO C 225 5.463 -27. ,994 3. .972 1. .00 18. .52 C

ANISOU 4875 CG PRO C 225 2528 2739 1769 -858 524 19 c

ATOM 4876 CD PRO C 225 5.300 -26. ,528 4. .203 1. .00 18. .81 c

ANISOU 4876 CD PRO C 225 2258 2876 2010 -531 473 19 c

ATOM 4877 N TYR C 226 1.079 -28. ,106 5. .170 1. .00 18. .68 N

ANISOU 4877 N TYR C 226 2332 3526 1239 -578 270 112 N

ATOM 4878 CA TYR C 226 0.090 -28. ,106 6. .248 1. .00 19. .55 C

ANISOU 4878 CA TYR C 226 2743 3723 961 -551 292 -3 C

ATOM 4879 C TYR C 226 0.169 -29. ,408 7. .064 1. .00 21. .08 C

ANISOU 4879 C TYR c 226 2801 3092 2114 -425 385 ^■235 C

ATOM 4880 O TYR c 226 0.191 -29. ,377 8. .289 1. .00 24. .46 O

ANISOU 4880 O TYR c 226 3122 4021 2149 -680 250 54 O

ATOM 4881 CB TYR c 226 -1.322 -27. ,894 5. .672 1. .00 21. .12 c

ANISOU 4881 CB TYR c 226 2660 3802 1560 -392 283 ^■478 c

ATOM 4882 CG TYR c 226 -2.452 -28. ,036 6. .670 1. .00 22. .84 c

ANISOU 4882 CG TYR c 226 2753 4226 1696 - 666 289 ^■477 c

ATOM 4883 CD1 TYR c 226 -2.959 -29. ,294 6. .980 1. .00 23. .32 c

ANISOU 4883 CD1 TYR c 226 2434 4346 2079 -800 -51 ^■275 c

ATOM 4884 CD2 TYR c 226 -3.023 -26. ,920 7. .285 1. .00 25. .93 c

ANISOU 4884 CD2 TYR c 226 3225 4884 1742 -267 167 ^■816 c

ATOM 4885 CE1 TYR c 226 -3.984 -29. ,451 7. .882 1. .00 25. .39 c

ANISOU 4885 CE1 TYR c 226 2668 5024 1953 -889 63 ^■789 c

ATOM 4886 CE2 TYR c 226 -4.069 -27. ,065 8. .197 1. .00 26. .17 c

ANISOU 4886 CE2 TYR c 226 3473 4844 1623 -303 186 ^■735 c

ATOM 4887 CZ TYR c 226 -4.542 -28. ,337 8. .482 1. .00 25. .43 c

ANISOU 4887 CZ TYR c 226 1653 5169 2838 -579 5 ^■790 c

ATOM 4888 OH TYR c 226 -5.548 -28. ,547 9. .373 1. .00 33. .35 0

ANISOU 4888 OH TYR c 226 2545 6425 3699 -1004 742 ^■630 0

ATOM 4889 N ASP c 227 0.212 -30. ,544 6. .378 1. .00 18. .86 N

ANISOU 4889 N ASP c 227 2581 3177 1407 -471 -41 ^■165 N

ATOM 4890 CA ASP c 227 0.212 -31. ,847 7. .034 1. .00 19. .11 c

ANISOU 4890 CA ASP c 227 2661 3033 1565 -455 345 ^■109 c

ATOM 4891 C ASP c 227 1.631 -32. ,262 7. .440 1. .00 20. .05 c

ANISOU 4891 C ASP c 227 2615 3421 1580 -698 195 126 c

ATOM 4892 O ASP c 227 2.230 -33. ,170 6. .845 1. .00 21. .13 0

ANISOU 4892 O ASP c 227 2445 3548 2034 -541 - 222 145 0

ATOM 4893 CB ASP c 227 -0.431 -32. ,904 6. .127 1. .00 18. .75 c

ANISOU 4893 CB ASP c 227 2438 3192 1493 -174 527 ^■499 c

ATOM 4894 CG ASP c 227 -0.664 -34. ,237 6. .842 1. .00 20. .76 c

ANISOU 4894 CG ASP c 227 2685 3446 1756 -177 592 ^■133 c

ATOM 4895 OD1 ASP c 227 -0.900 -34. ,211 8. .065 1. .00 21. .53 0

ANISOU 4895 OD1 ASP c 227 2437 3925 1815 -448 619 383 0

ATOM 4896 OD2 ASP c 227 -0.625 -35. ,311 6. .184 1. .00 19. .24 0

ANISOU 4896 OD2 ASP c 227 2344 3162 1804 -630 - 182 76 0

ATOM 4897 N ILE c 228 2.151 -31. ,589 8. .463 1. .00 22. .86 N

ANISOU 4897 N ILE c 228 2724 3739 2220 -915 -80 ^■116 N

ATOM 4898 CA ILE c 228 3.521 -31. ,778 8. .955 1. .00 22. .52 C

ANISOU 4898 CA ILE c 228 2725 3938 1892 -669 154 51 c

ATOM 4899 C ILE c 228 3.550 -31. ,575 10. .478 1. .00 23. .58 c ANISOU 4899 C ILE C 228 2868 4164 1927 -367 -288 60 C

ATOM 4900 O ILE C 228 2.575 -31. .081 11. .070 1. .00 25. .53 O

ANISOU 4900 O ILE C 228 2811 4851 2037 -125 162 767 O

ATOM 4901 CB ILE C 228 4.525 -30. .795 8. .277 1. .00 23. .34 C

ANISOU 4901 CB ILE C 228 3527 3616 1723 -758 380 100 C

ATOM 4902 CGI ILE C 228 4.110 -29. .326 8. .519 1. .00 20. .35 C

ANISOU 4902 CGI ILE C 228 2540 3395 1796 -1330 284 -358 C

ATOM 4903 CG2 ILE C 228 4.699 -31. .116 6. .783 1. .00 21. .75 C

ANISOU 4903 CG2 ILE C 228 2838 3568 1855 -993 584 -24 C

ATOM 4904 CD1 ILE C 228 5.168 -28. .291 8. .150 1. .00 18. .27 C

ANISOU 4904 CD1 ILE C 228 2188 2921 1830 -847 541 -509 C

ATOM 4905 N GLY C 229 4.645 -31. .981 11. .118 1. .00 26. .46 N

ANISOU 4905 N GLY C 229 2589 5127 2336 -1252 -827 277 N

ATOM 4906 CA GLY C 229 4.828 -31. .726 12. .546 1. .00 29. .94 C

ANISOU 4906 CA GLY C 229 4072 5082 2221 -1252 -894 546 C

ATOM 4907 C GLY C 229 4.710 -32. .935 13. .457 1. .00 32. .47 C

ANISOU 4907 C GLY C 229 4183 5931 2222 -1593 -328 984 C

ATOM 4908 O GLY C 229 5.180 -32. .902 14. .603 1. .00 38. .87 O

ANISOU 4908 O GLY C 229 4623 7837 2306 -1213 -669 1892 O

ATOM 4909 N GLY C 230 4.072 -33. .995 12. .961 1. .00 30. .55 N

ANISOU 4909 N GLY C 230 2952 5518 3138 -1145 -520 1331 N

ATOM 4910 CA GLY C 230 3.992 -35. .265 13. .696 1. .00 32. .39 C

ANISOU 4910 CA GLY C 230 4706 5390 2211 -1376 -69 1022 C

ATOM 4911 C GLY C 230 5.329 -35. .980 13. .619 1. .00 33. .28 C

ANISOU 4911 C GLY C 230 5041 5152 2451 -1169 177 1468 C

ATOM 4912 O GLY c 230 6.091 -35. .757 12. .675 1. .00 35. .86 O

ANISOU 4912 O GLY c 230 4434 6636 2555 -1207 104 1307 O

ATOM 4913 N PRO c 231 5.622 -36. .849 14. .599 1. .00 36. .90 N

ANISOU 4913 N PRO c 231 5767 5388 2864 -470 326 1660 N

ATOM 4914 CA PRO c 231 6.954 -37. .452 14. .745 1. .00 38. .62 C

ANISOU 4914 CA PRO c 231 5214 6019 3439 -1019 -16 1703 C

ATOM 4915 C PRO c 231 7.455 -38. .225 13. .521 1. .00 38. .05 C

ANISOU 4915 C PRO c 231 5388 5880 3190 -1031 -566 1887 C

ATOM 4916 O PRO c 231 8.658 -38. .245 13. .265 1. .00 40. .27 O

ANISOU 4916 O PRO c 231 5113 6763 3421 -773 -1478 2038 O

ATOM 4917 CB PRO c 231 6.790 -38. .395 15. .956 1. .00 42. .46 C

ANISOU 4917 CB PRO c 231 6065 6710 3355 -79 65 2007 C

ATOM 4918 CG PRO c 231 5.316 -38. .589 16. .125 1. .00 40. .88 c

ANISOU 4918 CG PRO c 231 6076 5720 3732 6 492 2224 c

ATOM 4919 CD PRO c 231 4.689 -37. .313 15. .645 1. .00 36. .06 c

ANISOU 4919 CD PRO c 231 5311 5180 3210 -137 612 1544 c

ATOM 4920 N ASP c 232 6.542 -38. .840 12. .770 1. .00 39. .43 N

ANISOU 4920 N ASP c 232 6665 5964 2352 -936 -995 1811 N

ATOM 4921 CA ASP c 232 6.909 -39. .673 11. .621 1. .00 35. .85 C

ANISOU 4921 CA ASP c 232 5821 4933 2866 -719 -930 2132 C

ATOM 4922 C ASP c 232 6.627 -38. .981 10. .278 1. .00 27. .90 C

ANISOU 4922 C ASP c 232 3500 4462 2638 -838 -431 1931 C

ATOM 4923 O ASP c 232 6.615 -39. .624 9. .217 1. .00 28. .41 O

ANISOU 4923 O ASP c 232 2214 5311 3268 -508 -550 1382 O

ATOM 4924 CB ASP c 232 6.185 -41. .029 11. .704 1. .00 35. .63 c

ANISOU 4924 CB ASP c 232 6884 3658 2996 262 -1785 2700 c

ATOM 4925 CG ASP c 232 6.517 -41. .806 12. .980 1. .00 46. .82 c

ANISOU 4925 CG ASP c 232 10875 4764 2148 823 -1761 2249 c

ATOM 4926 OD1 ASP c 232 7.412 -41. .387 13. .746 1. .00 55. .63 0

ANISOU 4926 OD1 ASP c 232 9222 8215 3698 -215 -2168 1818 0

ATOM 4927 OD2 ASP c 232 5.875 -42. .852 13. .227 1. .00 62. .94 0

ANISOU 4927 OD2 ASP c 232 10950 7329 5634 -822 5 3414 0

ATOM 4928 N GLN c 233 6.380 -37. .676 10. .323 1. .00 23. .66 N

ANISOU 4928 N GLN c 233 2817 4407 1766 -1086 -405 1370 N

ATOM 4929 CA GLN c 233 6.120 -36. .906 9. .097 1. .00 22. .61 C

ANISOU 4929 CA GLN c 233 1729 4583 2275 -591 -770 1606 C ATOM 4930 C GLN C 233 7.410 -36.,229 8..651 1..00 26..20 C

ANISOU 4930 C GLN C 233 2669 4840 2445 -1144 -231 1557 C

ATOM 4931 O GLN C 233 8.091 -35. ,596 9. .458 1. .00 30. .55 O

ANISOU 4931 O GLN C 233 4259 4339 3006 -1395 -489 1167 0

ATOM 4932 CB GLN C 233 5.032 -35. ,858 9. .329 1. .00 22. .59 c

ANISOU 4932 CB GLN C 233 2626 3586 2367 -906 -524 1300 c

ATOM 4933 CG GLN C 233 3.733 -36. ,437 9. .866 1. .00 23. .24 c

ANISOU 4933 CG GLN C 233 2864 3246 2719 -825 -323 1627 c

ATOM 4934 CD GLN C 233 2.594 -35. ,436 9. .843 1. .00 25. .52 c

ANISOU 4934 CD GLN C 233 3027 4216 2453 -393 -218 1022 c

ATOM 4935 OE1 GLN C 233 2.545 -34. ,517 10. .666 1. .00 27. .41 0

ANISOU 4935 OE1 GLN C 233 3618 4784 2011 -851 -971 756 0

ATOM 4936 NE2 GLN C 233 1.673 -35. ,602 8. .888 1. .00 25. .98 N

ANISOU 4936 NE2 GLN C 233 3309 4266 2294 -1283 -252 1240 N

ATOM 4937 N GLU C 234 7.748 -36. ,394 7. .373 1. .00 27. .52 N

ANISOU 4937 N GLU C 234 2458 5690 2306 -631 -358 1788 N

ATOM 4938 CA GLU C 234 8.943 -35. ,789 6. .790 1. .00 26. .40 C

ANISOU 4938 CA GLU C 234 2762 4594 2674 -404 -161 1938 C

ATOM 4939 C GLU C 234 8.670 -35. ,282 5. .380 1. .00 25. .41 C

ANISOU 4939 C GLU C 234 3151 4113 2388 -615 -365 1416 C

ATOM 4940 O GLU C 234 7.782 -35. ,788 4. .672 1. .00 22. .11 O

ANISOU 4940 O GLU C 234 2291 3338 2771 -53 -186 1228 O

ATOM 4941 CB GLU C 234 10.100 -36. ,793 6. .714 1. .00 26. .00 C

ANISOU 4941 CB GLU C 234 2821 4297 2761 -319 -661 1754 C

ATOM 4942 CG GLU c 234 10.333 -37. ,606 7. .970 1. .00 25. .07 C

ANISOU 4942 CG GLU c 234 2617 4510 2395 -251 -866 1516 C

ATOM 4943 CD GLU c 234 11.567 -38. ,484 7. .906 1. .00 32. .25 c

ANISOU 4943 CD GLU c 234 2798 5376 4078 207 -949 1770 c

ATOM 4944 OE1 GLU c 234 12.552 -38. ,117 7. .230 1. .00 35. .35 0

ANISOU 4944 OE1 GLU c 234 3964 6319 3147 791 -86 1357 0

ATOM 4945 OE2 GLU c 234 11.555 -39. ,545 8. .560 1. .00 35. .61 0

ANISOU 4945 OE2 GLU c 234 2446 5893 5189 141 -608 2497 0

ATOM 4946 N PHE c 235 9.453 -34. ,287 4. .964 1. .00 21. .50 N

ANISOU 4946 N PHE c 235 1889 4201 2079 -251 -366 1222 N

ATOM 4947 CA PHE c 235 9.391 -33. ,835 3. .585 1. .00 19. .83 C

ANISOU 4947 CA PHE c 235 1864 3556 2110 -121 -219 1123 C

ATOM 4948 C PHE c 235 10.726 -33. ,332 3. .080 1. .00 19. .88 C

ANISOU 4948 C PHE c 235 2080 3720 1750 -397 -92 766 C

ATOM 4949 O PHE c 235 11.630 -33. ,005 3. .874 1. .00 21. .26 0

ANISOU 4949 O PHE c 235 2390 3945 1742 -555 -374 948 0

ATOM 4950 CB PHE c 235 8.287 -32. ,772 3. .380 1. .00 19. .81 c

ANISOU 4950 CB PHE c 235 2238 2702 2584 -162 33 873 c

ATOM 4951 CG PHE c 235 8.621 -31. ,417 3. .945 1. .00 19. .39 c

ANISOU 4951 CG PHE c 235 2237 2977 2149 -203 -223 651 c

ATOM 4952 CD1 PHE c 235 8.270 -31. ,097 5. .248 1. .00 20. .32 c

ANISOU 4952 CD1 PHE c 235 2034 3513 2170 -523 93 567 c

ATOM 4953 CD2 PHE c 235 9.259 -30. ,454 3. .166 1. .00 17. .55 c

ANISOU 4953 CD2 PHE c 235 1722 3209 1734 -41 114 489 c

ATOM 4954 CE1 PHE c 235 8.554 -29. ,849 5. .780 1. .00 19. .20 c

ANISOU 4954 CE1 PHE c 235 1164 3734 2395 -548 -887 505 c

ATOM 4955 CE2 PHE c 235 9.559 -29. ,204 3. .692 1. .00 19. .75 c

ANISOU 4955 CE2 PHE c 235 1681 3798 2023 -346 -2 101 c

ATOM 4956 CZ PHE c 235 9.214 -28. ,904 5. .006 1. .00 23. .05 c

ANISOU 4956 CZ PHE c 235 2594 4095 2066 -497 244 189 c

ATOM 4957 N GLY c 236 10.816 -33. ,279 1. .754 1. .00 17. .42 N

ANISOU 4957 N GLY c 236 1637 3291 1691 69 -16 596 N

ATOM 4958 CA GLY c 236 11.930 -32. ,667 1. .027 1. .00 18. .24 C

ANISOU 4958 CA GLY c 236 2145 2853 1933 -823 -467 690 c

ATOM 4959 C GLY c 236 11.334 -31. ,897 -0. .134 1. .00 18. .52 c

ANISOU 4959 C GLY c 236 2162 2862 2013 -642 -316 771 c

ATOM 4960 O GLY c 236 10.131 -32. ,017 -0. .414 1. .00 17. .95 0 ANISOU 4960 O GLY C 236 1931 2636 2251 -236 - 110 781 O

ATOM 4961 N VAL C 237 12.148 -31. ,098 -0. .813 1. .00 16. .59 N

ANISOU 4961 N VAL C 237 1825 2973 1502 -425 - 349 762 N

ATOM 4962 CA VAL C 237 11.664 -30. ,303 -1. .945 1. .00 16. .84 C

ANISOU 4962 CA VAL C 237 1977 2966 1454 -101 - 189 704 C

ATOM 4963 C VAL C 237 12.718 -30. ,282 -3. .066 1. .00 17. .72 C

ANISOU 4963 C VAL C 237 1779 3073 1881 -397 -46 172 C

ATOM 4964 O VAL C 237 13.911 -30. ,145 -2. .791 1. .00 19. .93 O

ANISOU 4964 O VAL C 237 1895 3349 2328 -281 - 501 450 O

ATOM 4965 CB VAL C 237 11.326 -28. ,836 -1. .547 1. .00 15. .30 C

ANISOU 4965 CB VAL C 237 1045 2857 1911 -490 - 434 478 C

ATOM 4966 CGI VAL C 237 10.656 -28. ,107 -2. .714 1. .00 15. .65 c

ANISOU 4966 CGI VAL C 237 2056 2393 1496 -350 - 342 234 c

ATOM 4967 CG2 VAL C 237 10.452 -28. ,761 -0. .280 1. .00 17. .48 c

ANISOU 4967 CG2 VAL C 237 2266 2930 1445 -418 - 452 427 c

ATOM 4968 N ASP C 238 12.284 -30. ,454 -4. .321 1. .00 16. .89 N

ANISOU 4968 N ASP C 238 1314 3103 2000 -115 - 359 514 N

ATOM 4969 CA ASP C 238 13.136 -30. ,150 -5. .471 1. .00 17. .30 C

ANISOU 4969 CA ASP c 238 2069 2587 1917 58 - 130 318 C

ATOM 4970 C ASP c 238 12.520 -28. ,949 -6. .145 1. .00 15. .77 C

ANISOU 4970 C ASP c 238 1791 2305 1894 -120 94 332 C

ATOM 4971 O ASP c 238 11.357 -29. ,003 -6. .556 1. .00 16. .56 O

ANISOU 4971 O ASP c 238 1947 2608 1736 -186 -87 274 O

ATOM 4972 CB ASP c 238 13.222 -31. ,317 -6. .464 1. .00 19. .64 c

ANISOU 4972 CB ASP c 238 2646 2339 2477 418 - 318 202 c

ATOM 4973 CG ASP c 238 13.995 -32. ,508 -5. .909 1. .00 26. .18 c

ANISOU 4973 CG ASP c 238 3761 2671 3514 949 - 174 495 c

ATOM 4974 OD1 ASP c 238 14.865 -32. ,308 -5. .042 1. .00 37. .14 0

ANISOU 4974 OD1 ASP c 238 5716 4763 3630 1781 -1285 664 0

ATOM 4975 OD2 ASP c 238 13.741 -33. ,645 -6. .357 1. .00 36. .56 0

ANISOU 4975 OD2 ASP c 238 6050 2846 4993 0 280 629 0

ATOM 4976 N VAL c 239 13.269 -27. ,850 -6. .211 1. .00 13. .89 N

ANISOU 4976 N VAL c 239 1085 2378 1812 59 47 410 N

ATOM 4977 CA VAL c 239 12.756 -26. ,617 -6. .779 1. .00 13. .51 C

ANISOU 4977 CA VAL c 239 1264 2155 1714 -175 -62 332 C

ATOM 4978 C VAL c 239 13.143 -26. ,598 -8. .254 1. .00 14. .62 C

ANISOU 4978 C VAL c 239 1751 2200 1602 -177 - 234 385 C

ATOM 4979 O VAL c 239 14.333 -26. ,582 -8. .590 1. .00 16. .11 0

ANISOU 4979 O VAL c 239 1744 2426 1950 262 - 270 469 0

ATOM 4980 CB VAL c 239 13.328 -25. ,377 -6. .052 1. .00 14. .30 c

ANISOU 4980 CB VAL c 239 1988 2062 1381 -66 44 193 c

ATOM 4981 CGI VAL c 239 12.775 -24. ,081 -6. .655 1. .00 13. .53 c

ANISOU 4981 CGI VAL c 239 1168 2449 1521 -214 - 142 455 c

ATOM 4982 CG2 VAL c 239 12.966 -25. ,428 -4. .581 1. .00 15. .99 c

ANISOU 4982 CG2 VAL c 239 2298 2366 1411 215 121 336 c

ATOM 4983 N GLY c 240 12.149 -26. ,620 -9. .140 1. .00 13. .21 N

ANISOU 4983 N GLY c 240 1836 1711 1470 -233 - 215 424 N

ATOM 4984 CA GLY c 240 12.439 -26. ,540 -10. .562 1. .00 14. .43 C

ANISOU 4984 CA GLY c 240 1415 2480 1588 -14 -30 328 C

ATOM 4985 C GLY c 240 12.801 -25. ,133 -10. .994 1. .00 13. .79 C

ANISOU 4985 C GLY c 240 1349 2309 1580 142 - 129 393 C

ATOM 4986 O GLY c 240 12.535 -24. ,165 -10. .274 1. .00 14. .67 0

ANISOU 4986 O GLY c 240 1547 2519 1507 29 224 511 0

ATOM 4987 N PRO c 241 13.447 -25. ,004 -12. .161 1. .00 14. .73 N

ANISOU 4987 N PRO c 241 1772 2255 1568 123 -42 320 N

ATOM 4988 CA PRO c 241 13.843 -23. ,676 -12. .639 1. .00 14. .32 C

ANISOU 4988 CA PRO c 241 1668 2267 1503 -58 -97 151 C

ATOM 4989 C PRO c 241 12.632 -22. ,833 -12. .981 1. .00 16. .10 C

ANISOU 4989 C PRO c 241 1800 2306 2010 20 -41 216 C

ATOM 4990 O PRO c 241 11.581 -23. ,378 -13. .360 1. .00 16. .44 O

ANISOU 4990 O PRO c 241 1604 2945 1694 -105 -7 721 O ATOM 4991 CB PRO C 241 14.657 -23..983 -13..908 1..00 15..33 C

ANISOU 4991 CB PRO C 241 1930 2520 1373 -118 - 106 151 C

ATOM 4992 CG PRO C 241 14.201 -25. .328 -14. .339 1. .00 19. .08 C

ANISOU 4992 CG PRO C 241 2841 2475 1932 -242 187 306 C

ATOM 4993 CD PRO C 241 13.879 -26. .078 -13. .078 1. .00 15. .27 C

ANISOU 4993 CD PRO C 241 1817 2422 1564 -297 47 43 C

ATOM 4994 N VAL C 242 12.767 -21. .519 -12. .821 1. .00 14. .54 N

ANISOU 4994 N VAL C 242 1469 2269 1786 382 -46 -33 N

ATOM 4995 CA VAL C 242 11.752 -20. .595 -13. .302 1. .00 14. .58 C

ANISOU 4995 CA VAL C 242 1790 2158 1589 341 -60 169 C

ATOM 4996 C VAL C 242 12.003 -20. .351 -14. .794 1. .00 14. .07 C

ANISOU 4996 C VAL C 242 1616 2100 1628 -92 - 192 266 C

ATOM 4997 O VAL C 242 13.107 -19. .999 -15. .187 1. .00 14. .05 O

ANISOU 4997 O VAL C 242 1545 2071 1720 -207 - 321 33 O

ATOM 4998 CB VAL C 242 11.690 -19. .301 -12. .469 1. .00 13. .84 C

ANISOU 4998 CB VAL C 242 1093 1928 2237 15 - 302 61 C

ATOM 4999 CGI VAL C 242 13.030 -18. .561 -12. .432 1. .00 12. .72 C

ANISOU 4999 CGI VAL C 242 1368 1773 1690 -206 - 384 182 c

ATOM 5000 CG2 VAL C 242 10.553 -18. .404 -12. .957 1. .00 13. .52 c

ANISOU 5000 CG2 VAL C 242 1224 1947 1964 49 - 422 40 c

ATOM 5001 N CYS C 243 10.986 -20. .601 -15. .621 1. .00 13. .82 N

ANISOU 5001 N CYS C 243 1283 2138 1828 -21 - 150 298 N

ATOM 5002 CA CYS C 243 11.134 -20. .493 -17. .056 1. .00 13. .17 C

ANISOU 5002 CA CYS c 243 1345 1891 1768 -210 - 153 485 C

ATOM 5003 C CYS c 243 10.294 -19. .348 -17. .600 1. .00 13. .37 C

ANISOU 5003 C CYS c 243 1527 1698 1852 -113 -92 334 C

ATOM 5004 O CYS c 243 9.119 -19. .214 -17. .266 1. .00 18. .46 O

ANISOU 5004 O CYS c 243 1705 2972 2335 411 31 817 O

ATOM 5005 CB CYS c 243 10.747 -21. .803 -17. .752 1. .00 16. .17 c

ANISOU 5005 CB CYS c 243 1766 2070 2305 -396 - 145 262 c

ATOM 5006 SG CYS c 243 11.812 -23. .191 -17. .308 1. .00 18. .53 s

ANISOU 5006 SG CYS c 243 2126 2215 2700 -270 - 369 281 s

ATOM 5007 N PHE c 244 10.912 -18. .541 -18. .453 1. .00 11. .90 N

ANISOU 5007 N PHE c 244 1360 1416 1742 -62 - 318 356 N

ATOM 5008 CA PHE c 244 10.291 -17. .359 -19. .066 1. .00 13. .50 C

ANISOU 5008 CA PHE c 244 1605 1343 2182 255 - 417 67 C

ATOM 5009 C PHE c 244 10.229 -17. .468 -20. .579 1. .00 16. .00 C

ANISOU 5009 C PHE c 244 1881 2034 2163 309 -68 82 C

ATOM 5010 O PHE c 244 11.214 -17. .856 -21. .220 1. .00 15. .20 O

ANISOU 5010 O PHE c 244 1555 1954 2264 525 - 317 48 0

ATOM 5011 CB PHE c 244 11.124 -16. .112 -18. .748 1. .00 12. .94 c

ANISOU 5011 CB PHE c 244 1262 1754 1898 49 - 326 5 c

ATOM 5012 CG PHE c 244 11.148 -15. .749 -17. .298 1. .00 13. .67 c

ANISOU 5012 CG PHE c 244 1574 1862 1755 42 - 149 201 c

ATOM 5013 CD1 PHE c 244 10.189 -14. .898 -16. .772 1. .00 15. .63 c

ANISOU 5013 CD1 PHE c 244 2028 1939 1971 -53 19 -336 c

ATOM 5014 CD2 PHE c 244 12.124 -16. .260 -16. .452 1. .00 15. .08 c

ANISOU 5014 CD2 PHE c 244 1504 2083 2140 -102 - 353 314 c

ATOM 5015 CE1 PHE c 244 10.210 -14. .552 -15. .422 1. .00 17. .37 c

ANISOU 5015 CE1 PHE c 244 2047 2733 1818 310 - 374 -237 c

ATOM 5016 CE2 PHE c 244 12.149 -15. .916 -15. .099 1. .00 16. .37 c

ANISOU 5016 CE2 PHE c 244 1721 2200 2296 282 - 476 76 c

ATOM 5017 CZ PHE c 244 11.186 -15. .068 -14. .579 1. .00 16. .61 c

ANISOU 5017 CZ PHE c 244 2511 2055 1744 459 - 194 157 c

ATOM 5018 N LEU c 245 9.082 -17. .098 -21. .150 1. .00 16. .89 N

ANISOU 5018 N LEU c 245 1827 2679 1908 -55 - 272 -66 N

ATOM 5019 CA LEU c 245 8.940 -16. .992 -22. .605 1. .00 18. .73 C

ANISOU 5019 CA LEU c 245 2198 2910 2007 -132 - 449 -343 c

ATOM 5020 C LEU c 245 7.864 -15. .977 -22. .927 1. .00 20. .43 c

ANISOU 5020 C LEU c 245 2777 2665 2321 -119 - 512 -126 c

ATOM 5021 O LEU c 245 6.740 -16. .061 -22. .398 1. .00 22. .71 0 ANISOU 5021 O LEU C 245 3013 3273 2341 19 -300 332 O

ATOM 5022 CB LEU C 245 8.579 -18.353 -23.207 1.00 20.20 C

ANISOU 5022 CB LEU C 245 2386 2892 2396 -82 -581 -561 C

ATOM 5023 CG LEU C 245 8.299 -18.392 -24.715 1.00 23.06 C

ANISOU 5023 CG LEU C 245 2749 3403 2609 279 -971 188 C

ATOM 5024 CD1 LEU C 245 9.511 -17.961 -25.542 1.00 22.53 C

ANISOU 5024 CD1 LEU C 245 3354 2803 2400 292 -622 411 C

ATOM 5025 CD2 LEU C 245 7.804 -19.771 -25.129 1.00 27.09 C

ANISOU 5025 CD2 LEU C 245 2961 3689 3640 493 -710 -872 C

ATOM 5026 OXT LEU C 245 8.083 -15.055 -23.712 1.00 21.08 O

ANISOU 5026 OXT LEU C 245 2615 3428 1965 165 47 -58 O

TER 5027 LEU C 245

HETATM 5028 CA CA A 246 14.110 -7.329 -30.919 1.00 16.65 CA

ANISOU 5028 CA CA A 246 2295 2553 1478 558 299 239 CA

HETATM 5029 N N03 A1246 17.995 5.962 -33.324 1.00 31.27 N

ANISOU 5029 N N03 A1246 4548 3648 3685 -53 -308 -694 N

HETATM 5030 01 N03 A1246 18.778 5.822 -32.186 1.00 36.80 O

ANISOU 5030 01 N03 A1246 4415 6414 3153 -233 263 -263 O

HETATM 5031 02 N03 A1246 16.837 5.632 -33.283 1.00 39.51 O

ANISOU 5031 02 N03 A1246 4290 5238 5481 202 -303 -1000 O

HETATM 5032 03 N03 A1246 18.548 6.469 -34.498 1.00 39.79 O

ANISOU 5032 03 N03 A1246 5395 5514 4210 245 -37 545 O

HETATM 5033 N N03 A1247 -27.541 -2.789 -34.090 1.00 41.84 N

ANISOU 5033 N N03 A1247 5126 4766 6004 18 243 397 N

HETATM 5034 01 N03 A1247 -26.759 -1.852 -34.765 1.00 42.19 O

ANISOU 5034 01 N03 A1247 5011 5338 5681 -1753 -1067 341 O

HETATM 5035 02 N03 A1247 -28.595 -2.483 -33.550 1.00 32.70 O

ANISOU 5035 02 N03 A1247 3890 5012 3520 -290 -552 514 O

HETATM 5036 03 N03 A1247 -27.083 -4.101 -34.053 1.00 40.59 O

ANISOU 5036 03 N03 A1247 4958 4578 5885 -253 -993 37 O

HETATM 5037 CA CA B 246 18.816 6.909 -25.010 1.00 16.16 CA

ANISOU 5037 CA CA B 246 1631 2424 2084 -234 -236 301 CA

HETATM 5038 N N03 B1246 -0.195 27.909 5.238 1.00 37.14 N

ANISOU 5038 N N03 B1246 4929 4642 4538 -358 -404 -39 N

HETATM 5039 01 N03 B1246 0.092 27.202 6.401 1.00 35.77 O

ANISOU 5039 01 N03 B1246 5327 3872 4390 -578 -613 -771 O

HETATM 5040 02 N03 B1246 -1.344 28.248 5.019 1.00 44.18 O

ANISOU 5040 02 N03 B1246 5086 5611 6088 -42 -495 924 O

HETATM 5041 03 N03 B1246 0.840 28.207 4.346 1.00 31.20 O

ANISOU 5041 03 N03 B1246 4202 3788 3863 -76 -489 -945 O

HETATM 5042 N N03 B1247 29.228 0.178 -17.946 1.00 29.85 N

ANISOU 5042 N N03 B1247 4515 3405 3422 381 -616 547 N

HETATM 5043 01 N03 B1247 30.614 0.246 -17.971 1.00 38.73 O

ANISOU 5043 01 N03 B1247 4689 4592 5433 -713 -263 951 O

HETATM 5044 02 N03 B1247 28.632 -0.655 -18.610 1.00 33.72 O

ANISOU 5044 02 N03 B1247 4804 3658 4349 -783 -85 469 O

HETATM 5045 03 N03 B1247 28.521 1.075 -17.161 1.00 32.73 O

ANISOU 5045 03 N03 B1247 4329 4392 3715 470 -328 417 O

HETATM 5046 CA CA C 246 24.152 -6.422 -17.996 1.00 13.29 CA

ANISOU 5046 CA CA C 246 1044 2006 1999 -103 90 7 CA

HETATM 5047 N N03 C1246 21.175 -12.395 -30.618 1.00 33.37 N

ANISOU 5047 N N03 C1246 5094 3615 3969 924 -205 976 N

HETATM 5048 01 N03 C1246 20.368 -11.284 -30.437 1.00 30.31 O

ANISOU 5048 01 N03 C1246 4018 4019 3478 758 222 138 O

HETATM 5049 02 N03 C1246 21.961 -12.449 -31.557 1.00 38.49 O

ANISOU 5049 02 N03 C1246 5871 5122 3631 461 -170 927 O

HETATM 5050 03 N03 C1246 21.078 -13.444 -29.707 1.00 29.02 O

ANISOU 5050 03 N03 C1246 3852 3227 3948 366 112 669 O

HETATM 5051 O HOH A2001 14.937 4.858 -42.694 1.00 40.49 O

ANISOU 5051 O HOH A2001 4829 5638 4916 2098 1552 1276 O

HETATM 5052 O HOH A2002 21.027 1.355 -42.270 1.00 40.86 O ANISOU 5052 O HOH A2002 3521 6895 5110 -1217 2453 -340 O

HETATM 5053 O HOH A2003 13.318 -1. ,060 -44. .629 1. .00 33. .00 O

ANISOU 5053 O HOH A2003 6841 3885 1810 192 -301 610 O

HETATM 5054 O HOH A2004 15.975 -2. ,631 -44. .610 1. .00 31. .81 O

ANISOU 5054 O HOH A2004 6074 3177 2836 217 1481 -301 O

HETATM 5055 O HOH A2005 14.043 -6. ,707 -38. .917 1. .00 33. .01 O

ANISOU 5055 O HOH A2005 5638 4118 2784 633 517 564 O

HETATM 5056 O HOH A2006 8.464 -9. ,066 -39. .966 1. .00 34. .04 O

ANISOU 5056 O HOH A2006 3658 5123 4153 709 646 -765 O

HETATM 5057 O HOH A2007 17.098 3. .762 -31. .164 1. .00 28. .17 O

ANISOU 5057 O HOH A2007 1533 3741 5428 -13 -32 -982 O

HETATM 5058 O HOH A2008 12.009 0. .418 -25. .646 1. .00 19. .06 O

ANISOU 5058 O HOH A2008 3024 2385 1830 57 -240 173 O

HETATM 5059 O HOH A2009 9.880 4. .166 -24. .406 1. .00 17. .93 O

ANISOU 5059 O HOH A2009 2318 2503 1990 315 -572 -94 O

HETATM 5060 O HOH A2010 10.358 6. .921 -26. .023 1. .00 27. .60 O

ANISOU 5060 O HOH A2010 5220 2934 2331 -422 180 350 O

HETATM 5061 O HOH A2011 23.297 1. .568 -44. .339 1. .00 38. .27 O

ANISOU 5061 O HOH A2011 3113 7320 4109 815 175 - 1421 O

HETATM 5062 O HOH A2012 7.814 4. ,785 -26. .164 1. .00 25. .19 O

ANISOU 5062 O HOH A2012 3418 3766 2386 -386 29 -340 O

HETATM 5063 O HOH A2013 7.676 7. .145 -29. .727 1. .00 15. .87 O

ANISOU 5063 O HOH A2013 1645 2135 2248 -333 -138 607 O

HETATM 5064 O HOH A2014 9.335 16. .082 -27. .096 1. .00 23. .86 O

ANISOU 5064 0 HOH A2014 3962 2550 2552 -82 -1244 220 O

HETATM 5065 0 HOH A2015 14.023 15. .544 -30. .589 0. .50 12. .49 O

ANISOU 5065 0 HOH A2015 1595 1512 1636 46 -383 1141 0

HETATM 5066 0 HOH A2016 13.957 16. .500 -28. .938 0. .50 18. .36 0

ANISOU 5066 0 HOH A2016 2027 2277 2672 -752 -109 537 0

HETATM 5067 0 HOH A2017 11.960 8. .972 -25. .000 1. .00 18. .42 0

ANISOU 5067 0 HOH A2017 2109 2293 2595 -79 -354 -123 0

HETATM 5068 0 HOH A2018 13.999 9. .520 -26. .990 1. .00 19. .04 0

ANISOU 5068 0 HOH A2018 2373 2536 2324 212 -838 58 0

HETATM 5069 0 HOH A2019 16.881 7. .108 -26. .471 1. .00 18. .21 0

ANISOU 5069 0 HOH A2019 1864 3066 1987 -69 13 204 0

HETATM 5070 0 HOH A2020 15.072 16. .066 -33. .183 1. .00 27. .62 0

ANISOU 5070 0 HOH A2020 2276 3647 4569 -1007 -266 167 0

HETATM 5071 0 HOH A2021 11.753 15. .585 -36. .652 1. .00 29. .13 0

ANISOU 5071 0 HOH A2021 3311 3462 4294 -564 -184 1779 0

HETATM 5072 0 HOH A2022 12.972 17. .070 -34. .495 1. .00 31. .56 0

ANISOU 5072 0 HOH A2022 4124 3056 4810 -1069 -321 1833 0

HETATM 5073 0 HOH A2023 23.147 7. .216 -30. .663 1. .00 32. .06 0

ANISOU 5073 0 HOH A2023 2722 7532 1926 743 -212 -171 0

HETATM 5074 0 HOH A2024 1.576 1. .119 -39. .892 1. .00 31. .22 0

ANISOU 5074 0 HOH A2024 4319 3916 3626 -358 -307 -261 0

HETATM 5075 0 HOH A2025 2.302 4. .332 -42. .284 1. .00 20. .93 0

ANISOU 5075 0 HOH A2025 2115 3335 2501 -888 543 -243 0

HETATM 5076 0 HOH A2026 12.850 13. ,234 -37. .522 1. .00 23. .17 0

ANISOU 5076 0 HOH A2026 1520 4386 2898 -315 291 1003 0

HETATM 5077 0 HOH A2027 11.218 15. .971 -39. .978 1. .00 31. .07 0

ANISOU 5077 0 HOH A2027 3766 3952 4086 1007 -583 390 0

HETATM 5078 0 HOH A2028 12.527 11. .566 -44. .526 1. .00 22. .59 0

ANISOU 5078 0 HOH A2028 3112 3785 1686 886 -247 -82 0

HETATM 5079 0 HOH A2029 3.948 14. .737 -38. .636 1. .00 20. .16 0

ANISOU 5079 0 HOH A2029 1114 3736 2810 99 -274 -797 0

HETATM 5080 0 HOH A2030 5.605 6. .506 -45. .318 1. .00 19. .36 0

ANISOU 5080 0 HOH A2030 2343 2883 2129 1259 465 597 0

HETATM 5081 0 HOH A2031 3.299 2. .021 -41. .621 1. .00 32. .71 0

ANISOU 5081 0 HOH A2031 4411 3726 4290 448 663 -138 0

HETATM 5082 0 HOH A2032 -2.468 11. ,284 -34. .483 1. .00 32. .47 0

ANISOU 5082 0 HOH A2032 2564 5202 4569 1891 -883 -586 0 HETATM 5083 O HOH A2033 -0.826 5 411 -39.063 1 00 18.32 O

ANISOU 5083 O HOH A2033 2208 2572 2181 602 617 -77 O

HETATM 5084 O HOH A2034 17.330 -4 566 -32.417 1 00 28.16 O

ANISOU 5084 O HOH A2034 1438 4552 4708 161 -115 1027 O

HETATM 5085 O HOH A2035 14.777 -2 406 -25.041 1 00 17.28 O

ANISOU 5085 O HOH A2035 1974 2433 2157 -98 -406 448 O

HETATM 5086 O HOH A2036 15.242 -8 759 -26.949 1 00 17.20 O

ANISOU 5086 O HOH A2036 2356 2231 1946 -203 316 -44 O

HETATM 5087 O HOH A2037 14.122 -9 512 -29.843 1 00 16.15 O

ANISOU 5087 O HOH A2037 1927 2176 2033 91 298 555 O

HETATM 5088 O HOH A2038 11.030 -10 709 -26.228 1 00 26.68 O

ANISOU 5088 O HOH A2038 3071 4224 2841 -51 957 -85 O

HETATM 5089 O HOH A2039 19.805 0 087 -27.216 1 00 28.04 O

ANISOU 5089 O HOH A2039 5694 1760 3198 1147 -588 -65 O

HETATM 5090 O HOH A2040 20.120 -4 533 -28.208 1 00 30.84 O

ANISOU 5090 O HOH A2040 2723 4105 4889 1801 -398 -171 O

HETATM 5091 O HOH A2041 -21.446 4 373 -19.163 1 00 23.69 O

ANISOU 5091 O HOH A2041 2456 4149 2394 -365 1218 321 O

HETATM 5092 O HOH A2042 13.932 -11 364 -32.673 1 00 26.53 O

ANISOU 5092 0 HOH A2042 3617 4144 2319 1491 -60 -42 O

HETATM 5093 0 HOH A2043 19.877 -8 826 -34.736 1 00 28.65 O

ANISOU 5093 0 HOH A2043 3556 4906 2422 1725 1667 1571 O

HETATM 5094 0 HOH A2044 10.033 -8 403 -38.026 1 00 30.02 O

ANISOU 5094 0 HOH A2044 4145 3586 3674 284 -296 -587 O

HETATM 5095 0 HOH A2045 -16.429 -7 892 -39.877 1 00 32.40 O

ANISOU 5095 0 HOH A2045 4215 3672 4423 -104 519 -891 O

HETATM 5096 0 HOH A2046 -10.875 -10 030 -36.874 1 00 38.95 O

ANISOU 5096 0 HOH A2046 6655 3214 4928 192 2604 102 O

HETATM 5097 0 HOH A2047 1.114 -0 537 -37.652 1 00 26.60 O

ANISOU 5097 0 HOH A2047 2089 4929 3086 1441 256 -1344 O

HETATM 5098 0 HOH A2048 7.296 15 632 -28.874 1 00 31.79 O

ANISOU 5098 0 HOH A2048 5727 3071 3280 311 -1809 155 O

HETATM 5099 0 HOH A2049 -6.163 8 622 -35.083 1 00 27.13 O

ANISOU 5099 0 HOH A2049 4593 3213 2502 1007 1044 450 O

HETATM 5100 0 HOH A2050 -0.619 13 824 -32.889 1 00 38.11 O

ANISOU 5100 0 HOH A2050 4557 5412 4510 61 58 784 O

HETATM 5101 0 HOH A2051 0.107 9 897 -28.118 1 00 25.10 O

ANISOU 5101 0 HOH A2051 3661 2020 3856 -356 851 27 O

HETATM 5102 0 HOH A2052 0.317 3 078 -37.965 1 00 21.83 O

ANISOU 5102 0 HOH A2052 2582 3014 2695 47 -585 61 O

HETATM 5103 0 HOH A2053 -0.506 -2 937 -37.362 1 00 30.42 O

ANISOU 5103 0 HOH A2053 3124 3687 4747 1078 694 -301 O

HETATM 5104 0 HOH A2054 -5.014 2 972 -39.210 1 00 27.24 O

ANISOU 5104 0 HOH A2054 3968 3375 3007 -476 407 922 O

HETATM 5105 0 HOH A2055 -5.691 1 775 -36.835 1 00 18.98 O

ANISOU 5105 0 HOH A2055 2052 2413 2743 611 -174 -904 O

HETATM 5106 0 HOH A2056 -4.301 -1 994 -40.605 1 00 27.73 O

ANISOU 5106 0 HOH A2056 4002 4270 2262 161 539 307 O

HETATM 5107 0 HOH A2057 -8.655 -5 481 -34.838 1 00 31.24 O

ANISOU 5107 0 HOH A2057 3935 4961 2974 804 -321 172 O

HETATM 5108 0 HOH A2058 -3.740 -7 792 -35.860 1 00 34.49 O

ANISOU 5108 0 HOH A2058 4544 4021 4540 -537 947 -526 O

HETATM 5109 0 HOH A2059 -9.810 -3 305 -41.774 1 00 38.22 O

ANISOU 5109 0 HOH A2059 7244 4221 3056 -1040 -534 -708 O

HETATM 5110 0 HOH A2060 -17.237 1 201 -40.800 1 00 33.82 O

ANISOU 5110 0 HOH A2060 5201 3986 3660 243 903 951 O

HETATM 5111 0 HOH A2061 -19.138 -0 334 -43.875 1 00 28.43 O

ANISOU 5111 0 HOH A2061 2535 5737 2530 -705 209 -706 O

HETATM 5112 0 HOH A2062 -20.989 7 418 -40.807 1 00 21.82 O

ANISOU 5112 0 HOH A2062 3138 3253 1898 907 361 114 O

HETATM 5113 0 HOH A2063 -24.155 -9 738 -36.174 1 00 36.82 O ANISOU 5113 O HOH A2063 4667 2682 6640 -568 -369 -576 O

HETATM 5114 O HOH A2064 -27.386 -5 514 -41.440 1 00 45.14 O

ANISOU 5114 O HOH A2064 4739 8239 4173 -1872 -504 -2099 O

HETATM 5115 O HOH A2065 -8.978 16 761 -23.932 1 00 33.07 O

ANISOU 5115 O HOH A2065 3854 4172 4537 1630 -993 -104 O

HETATM 5116 O HOH A2066 -28.532 -9 496 -34.869 1 00 43.79 O

ANISOU 5116 O HOH A2066 3817 6836 5983 -1516 1190 -2580 O

HETATM 5117 O HOH A2067 -24.888 -10 348 -32.354 1 00 27.69 O

ANISOU 5117 O HOH A2067 2392 4259 3870 -763 -183 -313 O

HETATM 5118 O HOH A2068 -17.700 18 937 -34.922 1 00 16.95 O

ANISOU 5118 O HOH A2068 1530 2228 2679 381 336 118 O

HETATM 5119 O HOH A2069 -11.122 17 232 -36.624 1 00 24.44 O

ANISOU 5119 O HOH A2069 2772 2730 3781 -636 245 -1504 O

HETATM 5120 O HOH A2070 -20.875 16 435 -36.070 1 00 21.23 O

ANISOU 5120 O HOH A2070 3348 1928 2788 -432 -248 570 O

HETATM 5121 O HOH A2071 -21.889 19 166 -32.914 1 00 19.36 O

ANISOU 5121 O HOH A2071 1779 2671 2906 -306 -286 60 O

HETATM 5122 O HOH A2072 -25.924 16 536 -35.672 1 00 29.37 O

ANISOU 5122 O HOH A2072 4151 3058 3949 -528 -237 365 O

HETATM 5123 O HOH A2073 -27.114 13 532 -39.429 1 00 34.17 O

ANISOU 5123 O HOH A2073 4140 4529 4312 362 557 521 O

HETATM 5124 O HOH A2074 -23.671 17 091 -36.209 1 00 30.55 O

ANISOU 5124 O HOH A2074 3041 2938 5627 235 6 1147 O

HETATM 5125 O HOH A2075 -28.085 -10 829 -31.917 1 00 41.81 O

ANISOU 5125 0 HOH A2075 4555 6928 4400 -3894 1110 -1903 O

HETATM 5126 0 HOH A2076 -29.674 -10 767 -29.354 1 00 46.87 O

ANISOU 5126 0 HOH A2076 4512 5538 7756 -2102 -889 -966 O

HETATM 5127 0 HOH A2077 -28.814 -2 407 -26.076 1 00 26.00 O

ANISOU 5127 0 HOH A2077 2327 3661 3888 -763 485 -913 O

HETATM 5128 0 HOH A2078 -25.457 -1 095 -19.298 1 00 34.46 O

ANISOU 5128 0 HOH A2078 5183 4819 3091 80 1453 464 O

HETATM 5129 0 HOH A2079 -23.791 5 018 -20.755 1 00 20.77 O

ANISOU 5129 0 HOH A2079 2248 3184 2459 940 954 732 O

HETATM 5130 0 HOH A2080 -21.711 -7 866 -23.502 1 00 21.41 O

ANISOU 5130 0 HOH A2080 2107 1960 4067 -126 161 696 O

HETATM 5131 0 HOH A2081 -21.161 -3 864 -19.646 1 00 36.25 O

ANISOU 5131 0 HOH A2081 3993 4714 5063 -239 -1294 639 O

HETATM 5132 0 HOH A2082 -18.526 -12 206 -30.046 1 00 31.75 O

ANISOU 5132 0 HOH A2082 3366 3706 4988 32 -512 -464 O

HETATM 5133 0 HOH A2083 -17.241 -9 945 -38.578 1 00 35.92 O

ANISOU 5133 0 HOH A2083 4731 4106 4810 329 642 -2021 O

HETATM 5134 0 HOH A2084 -11.468 -11 727 -30.925 1 00 38.06 O

ANISOU 5134 0 HOH A2084 4745 3448 6265 -325 800 -1184 O

HETATM 5135 0 HOH A2085 -9.018 -8 375 -34.553 1 00 34.11 O

ANISOU 5135 0 HOH A2085 4206 3953 4798 781 290 429 O

HETATM 5136 0 HOH A2086 -1.579 -9 358 -33.271 1 00 39.03 O

ANISOU 5136 0 HOH A2086 4867 4370 5593 546 -306 306 O

HETATM 5137 0 HOH A2087 -3.031 -6 839 -30.314 1 00 28.21 O

ANISOU 5137 0 HOH A2087 3937 2954 3825 824 -260 -66 O

HETATM 5138 0 HOH A2088 0.347 -12 976 -41.618 1 00 41.95 O

ANISOU 5138 0 HOH A2088 7055 4341 4542 -267 1039 1153 O

HETATM 5139 0 HOH A2089 1.059 -5 857 -24.495 1 00 19.13 O

ANISOU 5139 0 HOH A2089 1712 1963 3592 599 514 -98 O

HETATM 5140 0 HOH A2090 1.138 -7 722 -22.331 1 00 33.71 O

ANISOU 5140 0 HOH A2090 3839 4502 4466 321 1241 1090 O

HETATM 5141 0 HOH A2091 1.267 -11 921 -21.624 1 00 31.19 O

ANISOU 5141 0 HOH A2091 3533 4199 4118 853 -371 758 O

HETATM 5142 0 HOH A2092 3.538 -9 217 -22.416 1 00 24.69 O

ANISOU 5142 0 HOH A2092 2393 3179 3806 -242 -1088 769 O

HETATM 5143 0 HOH A2093 9.372 1 149 -25.081 1 00 20.41 O

ANISOU 5143 0 HOH A2093 2678 2389 2687 367 -204 378 O HETATM 5144 O HOH A2094 2.808 3 168 -18.703 1 00 25.69 O

ANISOU 5144 O HOH A2094 3027 3248 3485 717 -689 -574 O

HETATM 5145 O HOH A2095 1.646 -6 131 -20.121 1 00 39.72 O

ANISOU 5145 O HOH A2095 5303 5296 4490 1377 1430 2197 O

HETATM 5146 O HOH A2096 2.837 5 750 -19.689 1 00 27.12 O

ANISOU 5146 O HOH A2096 2834 4289 3181 15 -453 -760 O

HETATM 5147 O HOH A2097 -4.043 9 265 -31.042 1 00 30.48 O

ANISOU 5147 O HOH A2097 4466 3673 3442 -2002 -1586 1083 O

HETATM 5148 O HOH A2098 -5.683 7 291 -32.906 1 00 17.06 O

ANISOU 5148 O HOH A2098 2148 1592 2741 154 1281 380 O

HETATM 5149 O HOH A2099 -10.864 6 999 -35.414 1 00 24.71 O

ANISOU 5149 O HOH A2099 2716 3876 2795 -136 -608 1356 O

HETATM 5150 O HOH A2100 -13.083 9 868 -37.965 1 00 30.43 O

ANISOU 5150 O HOH A2100 4282 3962 3316 -244 2291 654 O

HETATM 5151 O HOH A2101 -26.996 9 284 -37.095 1 00 23.45 O

ANISOU 5151 O HOH A2101 2239 3558 3109 201 -576 -579 O

HETATM 5152 O HOH A2102 -29.535 8 508 -37.621 1 00 20.12 O

ANISOU 5152 O HOH A2102 1634 3120 2888 437 -403 502 O

HETATM 5153 O HOH A2103 -35.167 7 564 -37.864 1 00 36.13 O

ANISOU 5153 0 HOH A2103 3365 5430 4931 -589 283 -966 O

HETATM 5154 0 HOH A2104 -27.792 8 407 -34.490 1 00 19.42 O

ANISOU 5154 0 HOH A2104 2486 2254 2637 -713 -39 101 O

HETATM 5155 0 HOH A2105 -24.800 3 981 -27.277 1 00 16.77 O

ANISOU 5155 0 HOH A2105 1483 1807 3079 48 -153 -82 O

HETATM 5156 0 HOH A2106 -24.510 10 806 -29.737 1 00 11.69 O

ANISOU 5156 0 HOH A2106 1574 1242 1624 -271 -77 -97 O

HETATM 5157 0 HOH A2107 -27.123 9 614 -24.059 1 00 14.07 O

ANISOU 5157 0 HOH A2107 1640 2050 1654 -329 -160 -712 O

HETATM 5158 0 HOH A2108 -19.339 13 195 -20.242 1 00 33.38 O

ANISOU 5158 0 HOH A2108 4656 4415 3612 -1650 -1451 1570 O

HETATM 5159 0 HOH A2109 -18.107 16 265 -22.387 1 00 20.49 O

ANISOU 5159 0 HOH A2109 2212 3083 2488 13 -118 412 O

HETATM 5160 0 HOH A2110 -32.264 12 563 -29.526 1 00 27.94 O

ANISOU 5160 0 HOH A2110 1515 5497 3603 -191 82 -829 O

HETATM 5161 0 HOH A2111 -30.731 9 545 -22.650 1 00 23.00 O

ANISOU 5161 0 HOH A2111 2176 3310 3250 -782 245 -623 O

HETATM 5162 0 HOH A2112 -30.177 18 846 -26.020 1 00 37.70 O

ANISOU 5162 0 HOH A2112 5551 4601 4173 208 394 -1542 O

HETATM 5163 0 HOH A2113 -34.074 14 364 -19.914 1 00 27.49 O

ANISOU 5163 0 HOH A2113 3495 4135 2814 -286 1302 -753 O

HETATM 5164 0 HOH A2114 -28.236 19 243 -22.053 1 00 28.17 O

ANISOU 5164 0 HOH A2114 3734 2759 4209 -781 -855 -770 O

HETATM 5165 0 HOH A2115 -23.138 8 221 -18.929 1 00 25.06 O

ANISOU 5165 0 HOH A2115 1856 4650 3015 379 -391 357 O

HETATM 5166 0 HOH A2116 -19.770 5 623 -21.168 1 00 16.85 O

ANISOU 5166 0 HOH A2116 1479 2420 2502 -256 -126 10 O

HETATM 5167 0 HOH A2117 -8.486 -5 493 -21.150 1 00 31.28 O

ANISOU 5167 0 HOH A2117 3774 3219 4890 743 -790 491 O

HETATM 5168 0 HOH A2118 -3.016 -6 420 -22.437 1 00 40.54 O

ANISOU 5168 0 HOH A2118 3701 4733 6969 130 142 895 O

HETATM 5169 0 HOH A2119 -3.911 -5 147 -25.611 1 00 29.19 O

ANISOU 5169 0 HOH A2119 2588 3492 5010 559 -7 -310 O

HETATM 5170 0 HOH A2120 -7.659 -0 341 -19.024 1 00 15.92 O

ANISOU 5170 0 HOH A2120 1172 2526 2350 486 232 616 O

HETATM 5171 0 HOH A2121 -5.272 1 185 -15.043 1 00 28.56 O

ANISOU 5171 0 HOH A2121 3284 4384 3181 1277 688 546 O

HETATM 5172 0 HOH A2122 -21.797 2 534 -17.111 1 00 32.02 O

ANISOU 5172 0 HOH A2122 3507 5258 3401 -1194 1084 748 O

HETATM 5173 0 HOH A2123 -16.496 12 280 -21.293 1 00 31.49 O

ANISOU 5173 0 HOH A2123 3543 4464 3957 -568 -21 341 O

HETATM 5174 0 HOH A2124 -20.716 6 937 -17.992 1 00 22.43 O ANISOU 5174 O HOH A2124 3159 3593 1767 369 -323 161 O

HETATM 5175 O HOH A2125 -20.357 5 967 -15.422 1 00 34.30 O

ANISOU 5175 O HOH A2125 5574 5382 2073 -185 -818 399 O

HETATM 5176 O HOH A2126 -14.829 6 711 -16.030 1 00 25.19 O

ANISOU 5176 O HOH A2126 2295 3871 3403 499 714 -606 O

HETATM 5177 O HOH A2127 -16.443 5 165 -12.671 1 00 40.07 O

ANISOU 5177 O HOH A2127 4309 6632 4283 1214 -451 1429 O

HETATM 5178 O HOH A2128 -9.479 10 677 -18.587 1 00 23.50 O

ANISOU 5178 O HOH A2128 2875 3393 2660 526 -39 -565 O

HETATM 5179 O HOH A2129 -9.007 10 860 -22.317 1 00 24.19 O

ANISOU 5179 O HOH A2129 2257 3663 3270 681 -614 -1853 O

HETATM 5180 O HOH A2130 -10.500 16 443 -26.166 1 00 34.11 O

ANISOU 5180 O HOH A2130 3717 4418 4824 2018 -1565 -412 O

HETATM 5181 O HOH A2131 -9.076 12 471 -24.438 1 00 34.07 O

ANISOU 5181 O HOH A2131 3967 4879 4097 -875 -875 -425 O

HETATM 5182 O HOH A2132 -15.947 14 819 -23.804 1 00 23.50 O

ANISOU 5182 O HOH A2132 2666 3569 2692 971 326 -809 O

HETATM 5183 O HOH A2133 -15.254 18 905 -33.760 1 00 19.06 O

ANISOU 5183 O HOH A2133 2252 2490 2499 272 684 537 O

HETATM 5184 O HOH A2134 -13.223 17 192 -35.072 1 00 30.56 O

ANISOU 5184 O HOH A2134 3609 3879 4121 -129 1916 1062 O

HETATM 5185 O HOH A2135 -12.860 18 494 -30.494 1 00 21.41 O

ANISOU 5185 O HOH A2135 1781 3961 2392 -181 189 -205 O

HETATM 5186 O HOH A2136 -13.159 14 685 -34.562 1 00 25.91 O

ANISOU 5186 0 HOH A2136 3389 3264 3191 -89 -85 -25 O

HETATM 5187 0 HOH A2137 -19.837 13 950 -36.862 1 00 19.51 O

ANISOU 5187 0 HOH A2137 3505 2471 1434 -58 -660 143 O

HETATM 5188 0 HOH A2138 -14.004 15 130 -38.876 1 00 36.89 O

ANISOU 5188 0 HOH A2138 4778 4739 4497 -224 -698 -775 O

HETATM 5189 0 HOH A2139 -19.963 17 422 -33.917 1 00 14.09 O

ANISOU 5189 0 HOH A2139 1727 1668 1955 99 123 295 O

HETATM 5190 0 HOH A2140 -23.766 17 511 -31.745 1 00 23.17 O

ANISOU 5190 0 HOH A2140 2993 2779 3029 119 947 -177 O

HETATM 5191 0 HOH A2141 -25.771 14 987 -33.807 1 00 23.70 O

ANISOU 5191 0 HOH A2141 3740 2364 2900 -162 -260 -590 O

HETATM 5192 0 HOH A2142 -22.598 15 987 -28.035 1 00 14.83 O

ANISOU 5192 0 HOH A2142 1392 2123 2119 124 -162 394 O

HETATM 5193 0 HOH A2143 -27.743 12 700 -35.359 1 00 21.91 O

ANISOU 5193 0 HOH A2143 3569 2714 2039 -487 -239 238 O

HETATM 5194 0 HOH A2144 -25.243 14 608 -37.604 1 00 23.78 O

ANISOU 5194 0 HOH A2144 2707 2903 3423 334 -301 389 O

HETATM 5195 0 HOH A2145 -28.094 11 617 -38.022 1 00 24.75 O

ANISOU 5195 0 HOH A2145 2505 3411 3486 164 344 -18 O

HETATM 5196 0 HOH A2146 -27.072 8 416 -44.728 1 00 27.62 O

ANISOU 5196 0 HOH A2146 3783 4743 1967 856 -1344 222 O

HETATM 5197 0 HOH A2147 -25.597 12 646 -41.540 1 00 30.15 O

ANISOU 5197 0 HOH A2147 3717 4074 3662 -283 -25 -140 O

HETATM 5198 0 HOH A2148 -6.970 10 483 -19.073 1 00 31.66 O

ANISOU 5198 0 HOH A2148 4036 4259 3732 -393 1307 -2221 O

HETATM 5199 0 HOH A2149 -3.035 10 540 -17.197 1 00 29.56 O

ANISOU 5199 0 HOH A2149 3157 5733 2341 -914 850 -2014 O

HETATM 5200 0 HOH A2150 0.050 8 193 -10.587 1 00 29.82 O

ANISOU 5200 0 HOH A2150 2868 4251 4211 988 681 -682 O

HETATM 5201 0 HOH A2151 0.927 2 682 -17.405 1 00 30.21 O

ANISOU 5201 0 HOH A2151 2782 4763 3931 -180 -474 514 O

HETATM 5202 0 HOH A2152 -4.834 8 572 -14.428 0 50 20.74 O

ANISOU 5202 0 HOH A2152 3320 1667 2890 -269 717 -761 O

HETATM 5203 0 HOH A2153 -3.803 7 679 -12.999 0 50 23.00 O

ANISOU 5203 0 HOH A2153 1248 4160 3329 -815 1677 -2271 O

HETATM 5204 0 HOH A2154 -34.964 -5 469 -33.259 1 00 40.85 O

ANISOU 5204 0 HOH A2154 6024 4450 5045 -702 -2035 -113 O HETATM 5205 O HOH A2155 -35.201 0.,825 -34..830 1..00 32..28 O

ANISOU 5205 O HOH A2155 2301 4645 5317 121 -596 348 O

HETATM 5206 O HOH A2156 -8.510 4. ,284 -38. .695 1. .00 33. .06 O

ANISOU 5206 O HOH A2156 5197 4579 2785 1162 -917 188 O

HETATM 5207 O HOH A2157 9.474 10. .403 -24. .921 1. .00 22. .00 O

ANISOU 5207 O HOH A2157 2738 3088 2534 -359 -193 191 O

HETATM 5208 O HOH B2001 31.978 13. .050 -23. .763 1. .00 34. .43 O

ANISOU 5208 O HOH B2001 2738 5160 5180 -1516 -260 1751 O

HETATM 5209 O HOH B2002 31.359 14. .022 -20. .763 1. .00 33. .67 O

ANISOU 5209 O HOH B2002 3120 4400 5272 -511 -664 767 O

HETATM 5210 O HOH B2003 25.189 11. .651 -25. .141 1. .00 30. .39 O

ANISOU 5210 O HOH B2003 2296 4104 5147 -641 -1089 1452 O

HETATM 5211 O HOH B2004 27.278 4. .680 -24. .490 1. .00 30. .19 O

ANISOU 5211 O HOH B2004 3325 4145 3998 -145 517 -133 O

HETATM 5212 O HOH B2005 24.707 3. .020 -22. .633 1. .00 26. .09 O

ANISOU 5212 O HOH B2005 3629 3815 2469 -421 856 545 O

HETATM 5213 O HOH B2006 26.030 0. ,363 -19. .290 1. .00 23. .14 O

ANISOU 5213 O HOH B2006 2633 2395 3762 220 -498 -109 O

HETATM 5214 O HOH B2007 17.678 -0. ,997 -13. .946 1. .00 18. .12 O

ANISOU 5214 O HOH B2007 1577 2626 2679 -294 134 -565 O

HETATM 5215 O HOH B2008 17.811 0. .613 -18. .007 1. .00 16. .64 O

ANISOU 5215 O HOH B2008 1792 1848 2681 256 94 476 0

HETATM 5216 O HOH B2009 16.341 1. .013 -15. .674 1. .00 17. .24 0

ANISOU 5216 O HOH B2009 2009 2394 2144 -193 95 -162 0

HETATM 5217 O HOH B2010 20.217 -1. ,466 -12. .029 1. .00 22. .04 0

ANISOU 5217 O HOH B2010 2043 3266 3064 -404 383 10 0

HETATM 5218 O HOH B2011 18.172 0. .958 -12. .059 1. .00 27. .27 0

ANISOU 5218 0 HOH B2011 3474 2868 4018 256 150 -231 0

HETATM 5219 0 HOH B2012 21.632 2. .469 -10. .347 1. .00 15. .28 0

ANISOU 5219 0 HOH B2012 1396 2517 1891 35 -184 -246 0

HETATM 5220 0 HOH B2013 28.994 -5. ,150 -7. .904 0. .50 17. .96 0

ANISOU 5220 0 HOH B2013 1994 3730 1097 1621 -1028 - 1641 0

HETATM 5221 0 HOH B2014 29.253 -3. ,838 -8. .166 0. .50 12. .22 0

ANISOU 5221 0 HOH B2014 812 1988 1843 -618 -25 54 0

HETATM 5222 0 HOH B2015 21.431 -3. ,891 -11. .910 1. .00 16. .51 0

ANISOU 5222 0 HOH B2015 1610 2268 2394 -252 86 -315 0

HETATM 5223 0 HOH B2016 24.314 -4. ,598 -16. .505 1. .00 15. .67 0

ANISOU 5223 0 HOH B2016 1493 2311 2149 -41 -542 116 0

HETATM 5224 0 HOH B2017 24.047 -3. ,910 -12. .782 1. .00 16. .28 0

ANISOU 5224 0 HOH B2017 2186 2182 1817 -131 -165 -527 0

HETATM 5225 0 HOH B2018 32.756 -1. ,665 -6. .296 1. .00 29. .54 0

ANISOU 5225 0 HOH B2018 3468 4569 3183 -585 -1387 920 0

HETATM 5226 0 HOH B2019 32.068 -3. ,063 -8. .442 1. .00 25. .40 0

ANISOU 5226 0 HOH B2019 2669 3776 3204 579 -1037 1 0

HETATM 5227 0 HOH B2020 32.174 -6. ,514 -10. .779 1. .00 33. .05 0

ANISOU 5227 0 HOH B2020 5153 4093 3311 244 -51 72 0

HETATM 5228 0 HOH B2021 34.442 10. .657 -14. .732 1. .00 35. .24 0

ANISOU 5228 0 HOH B2021 4146 5376 3864 -1575 -127 516 0

HETATM 5229 0 HOH B2022 32.534 2. .234 -8. .707 1. .00 21. .53 0

ANISOU 5229 0 HOH B2022 1577 2932 3671 459 -232 -905 0

HETATM 5230 0 HOH B2023 38.750 4. ,940 -6. .564 1. .00 39. .16 0

ANISOU 5230 0 HOH B2023 3454 6125 5299 -494 -2225 840 0

HETATM 5231 0 HOH B2024 36.418 8. .313 -10. .229 1. .00 20. .81 0

ANISOU 5231 0 HOH B2024 2379 3005 2523 224 89 -181 0

HETATM 5232 0 HOH B2025 33.318 7. .250 -4. .043 1. .00 29. .57 0

ANISOU 5232 0 HOH B2025 1467 6049 3716 552 -375 1027 0

HETATM 5233 0 HOH B2026 31.907 12. .123 -14. .614 1. .00 30. .20 0

ANISOU 5233 0 HOH B2026 3520 4634 3321 -1158 -1394 142 0

HETATM 5234 0 HOH B2027 22.718 4. .484 -25. .172 1. .00 29. .85 0

ANISOU 5234 0 HOH B2027 3308 3172 4862 603 1901 -374 0

HETATM 5235 0 HOH B2028 17.074 -0. ,321 -21. .338 1. .00 21. .87 0 ANISOU 5235 O HOH B2028 1968 3058 3283 299 -455 -307 O

HETATM 5236 O HOH B2029 16.108 0 009 -24.180 1.00 24.79 O

ANISOU 5236 O HOH B2029 3039 3154 3226 264 -240 913 O

HETATM 5237 O HOH B2030 20.698 16 304 -26.693 1.00 36.92 O

ANISOU 5237 O HOH B2030 5279 3885 4862 -2062 -734 252 O

HETATM 5238 O HOH B2031 21.475 14 529 -23.459 1.00 28.42 O

ANISOU 5238 O HOH B2031 4945 2631 3220 -1038 -497 391 O

HETATM 5239 O HOH B2032 7.411 24 321 -11.683 1.00 39.00 O

ANISOU 5239 O HOH B2032 2969 6633 5215 -727 1007 2437 O

HETATM 5240 O HOH B2033 19.741 15 185 -11.481 1.00 33.79 O

ANISOU 5240 O HOH B2033 5442 3763 3632 -960 1367 -1132 O

HETATM 5241 O HOH B2034 8.649 9 916 -13.392 1.00 31.73 O

ANISOU 5241 O HOH B2034 4088 3502 4467 331 1 -370 O

HETATM 5242 O HOH B2035 23.312 9 501 -2.806 1.00 36.02 O

ANISOU 5242 O HOH B2035 3764 5263 4659 88 -553 9 O

HETATM 5243 O HOH B2036 6.178 -2 200 -11.286 1.00 28.78 O

ANISOU 5243 O HOH B2036 3973 2333 4629 -207 605 -568 O

HETATM 5244 O HOH B2037 4.430 -1 151 -13.026 1.00 32.25 O

ANISOU 5244 O HOH B2037 4619 3197 4438 -880 -567 -58 O

HETATM 5245 O HOH B2038 17.522 3 290 -3.745 1.00 29.94 O

ANISOU 5245 O HOH B2038 2099 5309 3967 519 -57 691 O

HETATM 5246 O HOH B2039 16.636 18 199 0.245 1.00 33.51 O

ANISOU 5246 O HOH B2039 4204 3502 5026 -656 187 -488 O

HETATM 5247 O HOH B2040 20.949 13 961 -7.871 1.00 30.26 O

ANISOU 5247 O HOH B2040 2597 2959 5940 399 -1075 -2208 O

HETATM 5248 O HOH B2041 17.726 16 969 -12.314 1.00 28.62 O

ANISOU 5248 O HOH B2041 3491 3556 3824 -199 211 1 O

HETATM 5249 0 HOH B2042 19.179 17 887 -5.177 1.00 26.03 O

ANISOU 5249 0 HOH B2042 2282 3431 4177 -510 -164 -370 O

HETATM 5250 0 HOH B2043 16.503 16 988 -5.544 1.00 15.93 O

ANISOU 5250 0 HOH B2043 1734 2328 1990 115 202 -575 O

HETATM 5251 0 HOH B2044 18.060 20 587 -9.344 1.00 26.51 O

ANISOU 5251 0 HOH B2044 2402 3813 3858 -377 917 -766 O

HETATM 5252 0 HOH B2045 9.879 19 999 -8.816 1.00 26.38 O

ANISOU 5252 0 HOH B2045 2980 3334 3707 -449 357 -953 O

HETATM 5253 0 HOH B2046 15.766 24 388 -8.406 1.00 30.23 O

ANISOU 5253 0 HOH B2046 3587 3950 3947 -828 -722 257 O

HETATM 5254 0 HOH B2047 11.944 26 461 1.201 1.00 41.17 O

ANISOU 5254 0 HOH B2047 4267 7273 4102 -2051 -252 500 O

HETATM 5255 0 HOH B2048 12.220 30 244 1.259 1.00 26.21 O

ANISOU 5255 0 HOH B2048 2013 3948 3997 -861 1088 -1350 O

HETATM 5256 0 HOH B2049 3.662 34 847 3.306 1.00 39.65 O

ANISOU 5256 0 HOH B2049 4468 2794 7801 356 628 -1039 O

HETATM 5257 0 HOH B2050 -5.208 31 838 6.347 1.00 34.61 O

ANISOU 5257 0 HOH B2050 3812 5409 3928 1491 826 -443 O

HETATM 5258 0 HOH B2051 -3.692 28 692 -2.306 1.00 26.19 O

ANISOU 5258 0 HOH B2051 3026 3850 3072 1015 139 -889 O

HETATM 5259 0 HOH B2052 -0.535 30 697 -2.612 1.00 33.59 O

ANISOU 5259 0 HOH B2052 4061 2999 5701 679 -1111 -726 O

HETATM 5260 0 HOH B2053 10.535 22 582 18.623 1.00 28.09 O

ANISOU 5260 0 HOH B2053 2947 3994 3729 -155 -879 53 O

HETATM 5261 0 HOH B2054 -8.022 29 855 9.124 1.00 28.16 O

ANISOU 5261 0 HOH B2054 2307 2643 5748 151 1870 -1014 O

HETATM 5262 0 HOH B2055 -16.054 31 249 5.682 1.00 33.79 O

ANISOU 5262 0 HOH B2055 1792 5841 5204 -36 -261 -3354 O

HETATM 5263 0 HOH B2056 -5.217 25 297 10.636 1.00 34.55 O

ANISOU 5263 0 HOH B2056 3391 5648 4088 -923 790 35 O

HETATM 5264 0 HOH B2057 -6.303 22 135 6.357 1.00 35.15 O

ANISOU 5264 0 HOH B2057 3456 6291 3607 187 -861 -524 O

HETATM 5265 0 HOH B2058 -8.208 19 529 -0.231 1.00 29.73 O

ANISOU 5265 0 HOH B2058 1710 5416 4170 256 -1290 -306 O HETATM 5266 O HOH B2059 -2.931 12.,866 8.,775 1..00 26., 07 O

ANISOU 5266 O HOH B2059 2457 4511 2934 -1076 627 -681 O

HETATM 5267 O HOH B2060 -2.901 10. ,834 6. ,959 1. .00 28. , 77 O

ANISOU 5267 O HOH B2060 2149 4244 4535 -590 1504 -169 O

HETATM 5268 O HOH B2061 -6.424 19. ,166 -2. ,427 1. .00 26. , 23 O

ANISOU 5268 O HOH B2061 1555 4158 4251 1452 -2157 - 1423 O

HETATM 5269 O HOH B2062 -2.449 24. ,386 -7. ,873 1. .00 31. , 75 O

ANISOU 5269 O HOH B2062 4587 3551 3924 573 56 -850 O

HETATM 5270 O HOH B2063 2.688 21. ,222 -12. ,097 1. .00 29. , 74 O

ANISOU 5270 O HOH B2063 4939 4009 2350 1377 -804 -587 O

HETATM 5271 O HOH B2064 7.740 21. .177 -11. ,192 1. .00 33. , 72 O

ANISOU 5271 O HOH B2064 3753 5063 3994 1350 628 537 O

HETATM 5272 O HOH B2065 9.203 19. .924 -22. ,721 1. .00 34. , 72 O

ANISOU 5272 O HOH B2065 3556 3570 6066 969 418 1181 O

HETATM 5273 O HOH B2066 9.017 15. .374 -16. ,956 1. .00 35. , 78 O

ANISOU 5273 O HOH B2066 4623 3918 5054 -271 1299 756 O

HETATM 5274 O HOH B2067 6.562 16. .725 -24. ,207 1. .00 37. , 80 O

ANISOU 5274 O HOH B2067 6468 4025 3869 1701 -536 439 O

HETATM 5275 O HOH B2068 8.152 8. .182 -15. ,554 1. .00 18. , 12 O

ANISOU 5275 O HOH B2068 2149 2379 2357 530 606 -73 O

HETATM 5276 O HOH B2069 8.589 -0. ,887 -10. ,129 1. .00 22. , 45 O

ANISOU 5276 O HOH B2069 3857 2039 2634 -1083 55 -370 O

HETATM 5277 O HOH B2070 5.214 4. .838 -15. ,914 1. .00 32. , 48 O

ANISOU 5277 O HOH B2070 3738 4834 3768 -834 -1261 481 O

HETATM 5278 O HOH B2071 9.129 -4. ,562 -13. ,376 1. .00 25. , 57 0

ANISOU 5278 O HOH B2071 3079 3559 3075 -254 65 -25 0

HETATM 5279 O HOH B2072 11.812 -3. ,819 -10. ,963 1. .00 25. , 99 0

ANISOU 5279 0 HOH B2072 3561 2809 3501 -353 -42 -322 0

HETATM 5280 0 HOH B2073 11.493 -1. ,828 -8. ,051 1. .00 25. ,49 0

ANISOU 5280 0 HOH B2073 2124 4508 3052 420 182 -810 0

HETATM 5281 0 HOH B2074 12.838 -5. ,440 -6. ,228 1. .00 34. , 57 0

ANISOU 5281 0 HOH B2074 4869 3367 4897 -891 1208 -716 0

HETATM 5282 0 HOH B2075 16.528 11. .868 -1. ,442 1. .00 20. , 64 0

ANISOU 5282 0 HOH B2075 1565 3850 2427 -136 -143 -92 0

HETATM 5283 0 HOH B2076 17.032 14. .908 2. .950 1, .00 25. .92 0

ANISOU 5283 0 HOH B2076 2414 4550 2883 429 -822 - 1188 0

HETATM 5284 0 HOH B2077 14.869 16. .582 1. .702 1, .00 21. .16 0

ANISOU 5284 0 HOH B2077 1490 3367 3181 362 -308 - 1261 0

HETATM 5285 0 HOH B2078 16.592 18. .838 5. .103 1, .00 29. .76 0

ANISOU 5285 0 HOH B2078 1923 4980 4403 682 -868 - 1427 0

HETATM 5286 0 HOH B2079 12.822 25. .820 8. .299 1, .00 27. .17 0

ANISOU 5286 0 HOH B2079 1731 4825 3768 -300 -709 - 2025 0

HETATM 5287 0 HOH B2080 8.144 25. .007 13. .783 1, .00 27. .28 0

ANISOU 5287 0 HOH B2080 2902 4055 3409 341 -319 - 1174 0

HETATM 5288 0 HOH B2081 6.546 27. .068 14. .743 1, .00 20. .07 0

ANISOU 5288 0 HOH B2081 2638 2798 2189 385 -348 -809 0

HETATM 5289 0 HOH B2082 2.653 30. .255 17. .669 1, .00 30. .46 0

ANISOU 5289 0 HOH B2082 3919 4278 3375 444 -768 -132 0

HETATM 5290 0 HOH B2083 3.786 33. .391 15. .005 1, .00 38. .93 0

ANISOU 5290 0 HOH B2083 4941 3501 6349 1354 -2734 - 2399 0

HETATM 5291 0 HOH B2084 5.479 23. .827 13. .670 1, .00 19. .28 0

ANISOU 5291 0 HOH B2084 1962 2688 2674 219 -292 -675 0

HETATM 5292 0 HOH B2085 0.257 18. .744 8. .437 1, .00 20. .48 0

ANISOU 5292 0 HOH B2085 1976 3399 2404 33 85 -542 0

HETATM 5293 0 HOH B2086 5.530 17. ,625 13. ,394 1. .00 18. , 14 0

ANISOU 5293 0 HOH B2086 2420 2635 1837 333 248 -133 0

HETATM 5294 0 HOH B2087 -0.197 15. ,220 14. ,314 1. .00 20. , 70 0

ANISOU 5294 0 HOH B2087 2542 2209 3115 -395 412 - 1087 0

HETATM 5295 0 HOH B2088 5.293 7. .035 9. .562 1, .00 33. .05 0

ANISOU 5295 0 HOH B2088 3897 5130 3528 531 1159 861 0

HETATM 5296 0 HOH B2089 1.988 20. .670 19. .460 1, .00 30. .74 0 ANISOU 5296 O HOH B2089 3782 4388 3510 782 1217 -183 O

HETATM 5297 O HOH B2090 -3.390 15. ,950 16. .542 1. .00 37. , 23 O

ANISOU 5297 O HOH B2090 4108 4857 5178 262 1337 - 1196 O

HETATM 5298 O HOH B2091 -1.547 8. ,876 16. .300 1. .00 42. , 50 O

ANISOU 5298 O HOH B2091 5234 4957 5956 -2448 1093 494 O

HETATM 5299 O HOH B2092 -2.576 9. ,739 10. .530 1. .00 35. ,71 O

ANISOU 5299 O HOH B2092 4280 4660 4625 549 618 -158 O

HETATM 5300 O HOH B2093 -0.164 10. ,927 6. .748 1. .00 18. , 90 O

ANISOU 5300 O HOH B2093 2080 2488 2612 -255 304 -600 O

HETATM 5301 O HOH B2094 1.128 10. .230 -9. .578 1. .00 29. , 61 O

ANISOU 5301 O HOH B2094 1727 5688 3834 1054 -796 - 1367 O

HETATM 5302 O HOH B2095 6.317 10. .640 -11. .724 1. .00 23. , 22 O

ANISOU 5302 O HOH B2095 2945 3438 2437 693 -361 -476 O

HETATM 5303 O HOH B2096 2.280 5. .505 -5. .648 1. .00 12. , 23 O

ANISOU 5303 O HOH B2096 369 2715 1563 -392 -154 -427 O

HETATM 5304 O HOH B2097 2.062 0. .396 -6. .035 1. .00 30. , 78 O

ANISOU 5304 O HOH B2097 4198 3705 3791 -1262 -920 606 O

HETATM 5305 O HOH B2098 -0.984 5. ,374 2. .215 1. .00 34. , 17 O

ANISOU 5305 O HOH B2098 4482 3409 5092 79 597 32 O

HETATM 5306 O HOH B2099 -1.806 8. ,382 8. .309 1. .00 26. , 54 O

ANISOU 5306 O HOH B2099 2864 3736 3483 -448 969 -157 O

HETATM 5307 O HOH B2100 -0.212 4. ,009 4. .425 1. .00 30. , 02 O

ANISOU 5307 O HOH B2100 3638 4630 3136 30 915 -828 O

HETATM 5308 O HOH B2101 9.173 7. .238 11. .291 1, .00 29. .22 O

ANISOU 5308 O HOH B2101 4181 3251 3668 374 621 229 O

HETATM 5309 O HOH B2102 12.108 11. .131 13, .995 1, .00 40. .29 0

ANISOU 5309 O HOH B2102 5204 6061 4041 -119 -689 1054 0

HETATM 5310 0 HOH B2103 14.369 19. .237 12, .408 1, .00 35. .07 0

ANISOU 5310 0 HOH B2103 3744 6014 3565 532 -317 377 0

HETATM 5311 0 HOH B2104 8.177 12. .914 15, .842 1, .00 27. .30 0

ANISOU 5311 0 HOH B2104 2594 4872 2904 617 -898 221 0

HETATM 5312 0 HOH B2105 8.332 22. .757 16, .701 1, .00 26. .34 0

ANISOU 5312 0 HOH B2105 3633 3387 2985 511 252 -352 0

HETATM 5313 0 HOH B2106 1.786 23. ,893 19. .501 1. .00 40. , 55 0

ANISOU 5313 0 HOH B2106 5268 5803 4334 1471 1116 -25 0

HETATM 5314 0 HOH B2107 9.102 25. .423 16, .243 1, .00 24. .85 0

ANISOU 5314 0 HOH B2107 3376 3517 2545 1307 -731 -466 0

HETATM 5315 0 HOH B2108 12.688 28. .399 20, .817 1, .00 24. .52 0

ANISOU 5315 0 HOH B2108 2176 3590 3550 582 545 127 0

HETATM 5316 0 HOH B2109 12.577 31. .439 12, .979 1, .00 27. .57 0

ANISOU 5316 0 HOH B2109 3810 4145 2519 -2193 -316 -567 0

HETATM 5317 0 HOH B2110 10.146 3. .990 4, .245 1, .00 30. .00 0

HETATM 5318 0 HOH B2111 12.413 0. .221 5, .358 1, .00 30. .00 0

HETATM 5319 0 HOH B2112 8.399 -1. ,905 -0. .494 1. .00 38. , 05 0

ANISOU 5319 0 HOH B2112 5977 6220 2260 -3184 969 469 0

HETATM 5320 0 HOH B2113 5.036 -3. ,627 -1. .424 1. .00 35. , 92 0

ANISOU 5320 0 HOH B2113 5639 4011 3996 -42 812 265 0

HETATM 5321 0 HOH B2114 20.693 -3. ,423 -9. .226 1. .00 13. , 14 0

ANISOU 5321 0 HOH B2114 1384 2132 1476 129 0 -82 0

HETATM 5322 0 HOH C2001 29.486 -13. ,834 -32. .761 1. .00 30. , 72 0

ANISOU 5322 0 HOH C2001 3852 5220 2599 -1167 -38 -6 0

HETATM 5323 0 HOH C2002 32.342 -15. ,003 -27. .138 1. .00 37. ,81 0

ANISOU 5323 0 HOH C2002 2384 4287 7696 25 1568 -852 0

HETATM 5324 0 HOH C2003 27.295 -21. ,378 -23. .810 1. .00 33. , 83 0

ANISOU 5324 0 HOH C2003 3014 4761 5079 490 1699 1215 0

HETATM 5325 0 HOH C2004 30.826 -18. ,937 -22. .091 1. .00 29. , 32 0

ANISOU 5325 0 HOH C2004 3356 2742 5042 1360 453 -508 0

HETATM 5326 0 HOH C2005 32.917 -16. ,499 -23. .007 1. .00 23. ,76 0

ANISOU 5326 0 HOH C2005 1506 2764 4757 490 570 -21 0

HETATM 5327 0 HOH C2006 29.747 -11. ,572 -18. .828 1. .00 25. , 60 0

ANISOU 5327 0 HOH C2006 3121 3198 3408 662 -128 -486 0 HETATM 5328 O HOH C2007 26.729 -9..374 -25..534 1..00 24..82 O

ANISOU 5328 O HOH C2007 2354 2673 4401 150 147 1041 O

HETATM 5329 O HOH C2008 19.878 -10. .587 -27. .782 1. .00 17. .73 O

ANISOU 5329 O HOH C2008 2011 2476 2248 710 31 297 O

HETATM 5330 O HOH C2009 15.344 -2. .188 -22. .261 1. .00 17. .86 O

ANISOU 5330 O HOH C2009 2607 2303 1874 818 - 435 48 O

HETATM 5331 O HOH C2010 18.948 -2. .172 -21. .320 1. .00 18. .96 O

ANISOU 5331 O HOH C2010 1845 2993 2365 220 - 728 724 O

HETATM 5332 O HOH C2011 13.479 -10. .936 -26. .651 1. .00 19. .50 O

ANISOU 5332 O HOH C2011 2167 2844 2398 473 - 180 294 O

HETATM 5333 O HOH C2012 11.897 -14. .290 -22. .702 1. .00 17. .76 O

ANISOU 5333 O HOH C2012 1912 2612 2221 709 -86 58 O

HETATM 5334 O HOH C2013 13.503 -16. .424 -23. .470 1. .00 15. .48 O

ANISOU 5334 O HOH C2013 1602 2437 1842 41 - 256 -87 O

HETATM 5335 O HOH C2014 9.215 -12. .046 -27. .767 1. .00 33. .30 O

ANISOU 5335 O HOH C2014 2878 5300 4475 926 - 964 -846 O

HETATM 5336 O HOH C2015 13.673 -12. .814 -30. .778 1. .00 34. .90 O

ANISOU 5336 O HOH C2015 4131 4637 4493 946 - 321 -781 O

HETATM 5337 O HOH C2016 18.348 -22. .210 -31. .889 1. .00 23. .56 O

ANISOU 5337 O HOH C2016 2466 3665 2818 1204 619 -657 O

HETATM 5338 O HOH C2017 27.339 -27. .666 -22. .215 1. .00 31. .03 O

ANISOU 5338 O HOH C2017 1992 5087 4707 -921 - 100 1953 O

HETATM 5339 O HOH C2018 18.035 -25. .955 -32. .454 1. .00 35. .31 O

ANISOU 5339 O HOH C2018 5205 4229 3982 612 - 206 55 O

HETATM 5340 O HOH C2019 24.377 -25. .921 -30. .287 1. .00 22. .81 0

ANISOU 5340 O HOH C2019 2059 2782 3823 806 626 398 0

HETATM 5341 O HOH C2020 14.638 -28. .404 -25. .903 1. .00 14. .50 0

ANISOU 5341 0 HOH C2020 1539 2092 1876 82 - 526 580 0

HETATM 5342 0 HOH C2021 25.775 -25. .145 -24. .338 1. .00 24. .98 0

ANISOU 5342 0 HOH C2021 2526 3419 3545 1232 265 -718 0

HETATM 5343 0 HOH C2022 24.505 -27. .485 -22. .113 1. .00 15. .95 0

ANISOU 5343 0 HOH C2022 1455 1998 2605 -137 305 178 0

HETATM 5344 0 HOH C2023 22.782 -23. .917 -17. .456 1. .00 28. .35 0

ANISOU 5344 0 HOH C2023 3301 3417 4054 -191 - 393 349 0

HETATM 5345 0 HOH C2024 25.855 -27. .276 -17. .615 1. .00 35. .51 0

ANISOU 5345 0 HOH C2024 4271 4892 4327 -419 74 459 0

HETATM 5346 0 HOH C2025 25.954 -24. .932 -27. .227 1. .00 31. .24 0

ANISOU 5346 0 HOH C2025 3152 3514 5204 628 424 -814 0

HETATM 5347 0 HOH C2026 24.795 -7. .473 -22. .781 1. .00 24. .21 0

ANISOU 5347 0 HOH C2026 3149 4031 2017 90 667 343 0

HETATM 5348 0 HOH C2027 21.413 -8. .194 -27. .685 1. .00 27. .18 0

ANISOU 5348 0 HOH C2027 1975 3573 4779 773 341 1425 0

HETATM 5349 0 HOH C2028 25.572 -5. .093 -23. .368 1. .00 25. .52 0

ANISOU 5349 0 HOH C2028 4562 2668 2467 52 - 164 41 0

HETATM 5350 0 HOH C2029 -4.770 -23. .385 1. .035 1. .00 19. .05 0

ANISOU 5350 0 HOH C2029 1679 3288 2271 14 -78 -201 0

HETATM 5351 0 HOH C2030 30.636 -4. .791 -20. .565 1. .00 26. .21 0

ANISOU 5351 0 HOH C2030 3276 3706 2975 -938 940 -76 0

HETATM 5352 0 HOH C2031 28.095 -12. .649 -14. .315 1. .00 20. .61 0

ANISOU 5352 0 HOH C2031 1489 2616 3726 -122 - 436 699 0

HETATM 5353 0 HOH C2032 20.415 -21. .228 -14. .169 1. .00 17. .78 0

ANISOU 5353 0 HOH C2032 1191 2753 2809 -210 - 169 455 0

HETATM 5354 0 HOH C2033 22.524 -18. .862 -12. .809 1. .00 27. .26 0

ANISOU 5354 0 HOH C2033 4340 3794 2221 -1744 - 752 -7 0

HETATM 5355 0 HOH C2034 18.439 -23. .683 -15. .644 1. .00 16. .34 0

ANISOU 5355 0 HOH C2034 2463 2157 1587 107 - 112 446 0

HETATM 5356 0 HOH C2035 6.773 -6. .471 -16. .694 1. .00 24. .29 0

ANISOU 5356 0 HOH C2035 2074 4700 2455 -494 -42 -90 0

HETATM 5357 0 HOH C2036 7.182 -21. .634 -27. .814 1. .00 31. .20 0

ANISOU 5357 0 HOH C2036 2073 4659 5122 1006 - 869 - 1062 0

HETATM 5358 0 HOH C2037 7.483 -21. .169 -19. .378 1. .00 23. .44 0 ANISOU 5358 O HOH C2037 2495 4620 1788 -349 63 -702 O

HETATM 5359 O HOH C2038 8.951 -25 342 -18.723 1 00 28.17 O

ANISOU 5359 O HOH C2038 3236 4113 3355 -649 -244 -102 O

HETATM 5360 O HOH C2039 12.876 -30 165 -10.127 1 00 37.23 O

ANISOU 5360 O HOH C2039 5169 3803 5175 -60 -204 -172 O

HETATM 5361 O HOH C2040 21.380 -23 631 -15.268 1 00 28.40 O

ANISOU 5361 O HOH C2040 3034 2945 4811 292 -486 -216 O

HETATM 5362 O HOH C2041 21.696 -25 741 -13.287 1 00 39.56 O

ANISOU 5362 O HOH C2041 6055 4623 4350 650 300 874 O

HETATM 5363 O HOH C2042 16.112 -25 258 -10.375 1 00 19.01 O

ANISOU 5363 O HOH C2042 1750 2874 2596 -52 -228 417 O

HETATM 5364 O HOH C2043 21.386 -24 769 -9.040 1 00 28.19 O

ANISOU 5364 O HOH C2043 1899 4789 4022 453 -639 -702 O

HETATM 5365 O HOH C2044 18.425 -19 827 -1.095 1 00 32.16 O

ANISOU 5365 O HOH C2044 3103 4576 4540 -943 521 -460 O

HETATM 5366 O HOH C2045 -8.394 -24 412 2.124 1 00 26.60 O

ANISOU 5366 O HOH C2045 3212 3210 3684 -67 1002 -1232 O

HETATM 5367 O HOH C2046 17.281 -35 920 0.453 1 00 28.19 O

ANISOU 5367 O HOH C2046 2930 4630 3148 -432 885 699 O

HETATM 5368 O HOH C2047 9.988 -39 017 -2.646 1 00 25.55 O

ANISOU 5368 O HOH C2047 2317 3593 3796 -398 303 743 O

HETATM 5369 O HOH C2048 14.690 -28 371 11.109 1 00 43.06 O

ANISOU 5369 O HOH C2048 5296 8351 2714 -1437 -597 1867 O

HETATM 5370 O HOH C2049 14.799 -36 515 10.001 1 00 39.71 O

ANISOU 5370 O HOH C2049 5006 6954 3128 117 -424 2052 O

HETATM 5371 O HOH C2050 8.047 -32 502 8.986 1 00 39.75 O

ANISOU 5371 O HOH C2050 4216 4844 6042 829 -3859 514 O

HETATM 5372 0 HOH C2051 1.807 -40 880 -8.171 1 00 16.98 O

ANISOU 5372 0 HOH C2051 1269 2612 2568 -373 11 -120 O

HETATM 5373 0 HOH C2052 1.033 -28 014 10.493 1 00 30.16 O

ANISOU 5373 0 HOH C2052 3532 5431 2496 -958 334 -996 O

HETATM 5374 0 HOH C2053 -4.864 -25 983 2.179 1 00 21.55 O

ANISOU 5374 0 HOH C2053 2947 2838 2402 -349 647 -638 O

HETATM 5375 0 HOH C2054 5.029 -19 764 8.972 1 00 26.73 O

ANISOU 5375 0 HOH C2054 3866 4106 2182 -939 647 -1511 O

HETATM 5376 0 HOH C2055 20.953 -17 163 -6.188 1 00 32.62 O

ANISOU 5376 0 HOH C2055 1715 7811 2864 285 -422 818 O

HETATM 5377 0 HOH C2056 16.422 -14 385 -7.260 1 00 38.24 O

ANISOU 5377 0 HOH C2056 4175 5307 5045 104 -443 -1120 O

HETATM 5378 0 HOH C2057 28.227 -13 654 -11.557 1 00 34.03 O

ANISOU 5378 0 HOH C2057 5283 3384 4260 449 -1162 -331 O

HETATM 5379 0 HOH C2058 24.873 -19 825 -11.527 1 00 28.06 O

ANISOU 5379 0 HOH C2058 3517 2953 4189 -741 236 -94 O

HETATM 5380 0 HOH C2059 29.184 -10 241 -8.271 1 00 29.67 O

ANISOU 5380 0 HOH C2059 3678 4465 3129 24 -982 -381 O

HETATM 5381 0 HOH C2060 22.566 -12 901 -4.315 1 00 30.71 O

ANISOU 5381 0 HOH C2060 3017 4206 4444 -479 34 464 O

HETATM 5382 0 HOH C2061 21.658 -6 115 -2.609 1 00 30.14 O

ANISOU 5382 0 HOH C2061 3293 5049 3107 -746 -441 335 O

HETATM 5383 0 HOH C2062 12.840 -8 507 -9.535 1 00 19.06 O

ANISOU 5383 0 HOH C2062 1560 3548 2134 -243 97 -556 O

HETATM 5384 0 HOH C2063 9.119 -6 128 -15.405 1 00 23.38 O

ANISOU 5384 0 HOH C2063 2427 2790 3666 63 1288 -967 O

HETATM 5385 0 HOH C2064 5.883 -10 287 -19.065 1 00 22.93 O

ANISOU 5385 0 HOH C2064 1290 2752 4669 491 -773 -1052 O

HETATM 5386 0 HOH C2065 5.831 -8 482 -21.082 1 00 20.70 O

ANISOU 5386 0 HOH C2065 2187 2352 3326 101 -95 379 O

HETATM 5387 0 HOH C2066 5.596 -9 168 -16.513 1 00 33.76 O

ANISOU 5387 0 HOH C2066 3182 3106 6537 619 -1534 262 O

HETATM 5388 0 HOH C2067 12.018 -10 836 -8.076 1 00 31.67 O

ANISOU 5388 0 HOH C2067 3845 4541 3645 -447 -819 -277 O HETATM 5389 O HOH C2068 9.498 -7 233 -12.029 1.00 20.72 O

ANISOU 5389 O HOH C2068 2328 3043 2500 213 -121 -68 O

HETATM 5390 O HOH C2069 10.425 -13 992 -24.840 1.00 22.40 O

ANISOU 5390 O HOH C2069 3139 2751 2617 993 -212 -77 O

HETATM 5391 O HOH C2070 3.416 -10 814 -19.148 1.00 30.00 O

HETATM 5392 O HOH C2071 6.348 -14 303 -25.698 1.00 30.00 O

HETATM 5393 O HOH C2072 4.768 -17 745 -23.642 1.00 31.61 O

ANISOU 5393 O HOH C2072 4911 3972 3127 418 -1164 356 O

HETATM 5394 O HOH C2073 8.361 -24 599 -15.987 1.00 24.84 O

ANISOU 5394 O HOH C2073 3238 2923 3274 -38 -1182 288 O

HETATM 5395 O HOH C2074 10.053 -25 463 -13.716 1.00 17.87 O

ANISOU 5395 O HOH C2074 1154 2937 2697 -742 380 -320 O

HETATM 5396 O HOH C2075 10.245 -29 875 -9.606 1.00 24.22 O

ANISOU 5396 O HOH C2075 3349 3387 2465 274 -135 94 O

HETATM 5397 O HOH C2076 9.675 -34 397 -9.994 1.00 32.55 O

ANISOU 5397 O HOH C2076 3096 4875 4397 660 1447 -1107 O

HETATM 5398 O HOH C2077 3.874 -40 582 0.839 1.00 27.24 O

ANISOU 5398 O HOH C2077 3167 3755 3426 -414 319 934 O

HETATM 5399 O HOH C2078 3.771 -41 913 3.200 1.00 22.06 O

ANISOU 5399 O HOH C2078 2700 2890 2790 -714 -291 860 O

HETATM 5400 O HOH C2079 2.041 -38 920 2.346 1.00 23.86 O

ANISOU 5400 O HOH C2079 3675 3337 2053 -422 -682 132 O

HETATM 5401 O HOH C2080 0.164 -30 155 3.388 1.00 19.31 O

ANISOU 5401 O HOH C2080 1989 3256 2089 -411 41 -381 O

HETATM 5402 O HOH C2081 -1.471 -35 231 -1.571 1.00 13.04 O

ANISOU 5402 0 HOH C2081 1562 2037 1354 -205 294 -36 O

HETATM 5403 0 HOH C2082 -6.112 -32 254 1.554 1.00 18.00 O

ANISOU 5403 0 HOH C2082 2306 2454 2076 -480 -74 -407 O

HETATM 5404 0 HOH C2083 -7.270 -30 069 -9.645 1.00 21.41 O

ANISOU 5404 0 HOH C2083 2726 2851 2556 -224 -141 -111 O

HETATM 5405 0 HOH C2084 -6.998 -39 956 -3.791 1.00 35.05 O

ANISOU 5405 0 HOH C2084 5484 4551 3281 540 1250 784 O

HETATM 5406 0 HOH C2085 -5.339 -40 045 3.337 1.00 27.46 O

ANISOU 5406 0 HOH C2085 4051 3450 2932 -40 1351 1208 O

HETATM 5407 0 HOH C2086 -8.834 -33 241 3.859 1.00 24.61 O

ANISOU 5407 0 HOH C2086 1473 4018 3856 -663 1729 -585 O

HETATM 5408 0 HOH C2087 -11.157 -39 935 -2.463 1.00 38.66 O

ANISOU 5408 0 HOH C2087 6070 3865 4753 -638 770 -625 O

HETATM 5409 0 HOH C2088 -13.373 -40 883 4.854 1.00 15.49 O

ANISOU 5409 0 HOH C2088 1455 2086 2343 174 -118 -179 O

HETATM 5410 0 HOH C2089 -15.227 -36 004 2.049 1.00 28.37 O

ANISOU 5410 0 HOH C2089 3174 6438 1166 248 246 -661 O

HETATM 5411 0 HOH C2090 -11.364 -29 259 -1.464 1.00 31.65 O

ANISOU 5411 0 HOH C2090 3335 4800 3890 395 409 1014 O

HETATM 5412 0 HOH C2091 -7.715 -25 853 -0.189 1.00 22.76 O

ANISOU 5412 0 HOH C2091 2541 3199 2907 120 676 41 O

HETATM 5413 0 HOH C2092 -3.212 -24 501 -1.143 1.00 17.28 O

ANISOU 5413 0 HOH C2092 2270 2283 2011 -246 -238 -105 O

HETATM 5414 0 HOH C2093 8.096 -9 345 -8.745 1.00 29.30 O

ANISOU 5414 0 HOH C2093 3089 3134 4909 -731 520 275 O

HETATM 5415 0 HOH C2094 3.084 -13 282 -6.004 1.00 24.07 O

ANISOU 5415 0 HOH C2094 2712 2920 3513 115 960 -746 O

HETATM 5416 0 HOH C2095 -3.980 -17 628 -3.558 1.00 33.78 O

ANISOU 5416 0 HOH C2095 3240 4423 5170 22 307 885 O

HETATM 5417 0 HOH C2096 -4.962 -20 904 2.737 1.00 34.12 O

ANISOU 5417 0 HOH C2096 5147 4430 3386 553 176 -819 O

HETATM 5418 0 HOH C2097 -6.579 -23 355 -1.141 1.00 20.99 O

ANISOU 5418 0 HOH C2097 2242 3227 2505 -526 1213 -231 O

HETATM 5419 0 HOH C2098 -5.865 -19 004 -5.128 1.00 24.77 O

ANISOU 5419 0 HOH C2098 2815 3092 3505 324 1124 -145 O

HETATM 5420 0 HOH C2099 -8.125 -21 167 -0.461 1.00 32.65 O ANISOU 5420 O HOH C2099 3167 4670 4568 998 961 1070 O

HETATM 5421 O HOH C2100 -7.818 -16 668 -2.629 1 00 38.49 O

ANISOU 5421 O HOH C2100 4943 4440 5239 9 725 -53 O

HETATM 5422 O HOH C2101 -4.027 -20 085 -11.964 1 00 27.65 O

ANISOU 5422 O HOH C2101 2808 3879 3818 532 -191 149 O

HETATM 5423 O HOH C2102 -2.303 -16 234 -14.000 1 00 31.04 O

ANISOU 5423 O HOH C2102 1490 5153 5150 455 135 549 O

HETATM 5424 O HOH C2103 -1.071 -22 300 -12.941 1 00 26.79 O

ANISOU 5424 O HOH C2103 1700 3764 4713 -998 61 1185 O

HETATM 5425 O HOH C2104 -8.874 -22 609 -10.227 1 00 35.75 O

ANISOU 5425 O HOH C2104 2962 5482 5138 643 109 -209 O

HETATM 5426 O HOH C2105 -1.505 -28 784 -15.465 1 00 29.85 O

ANISOU 5426 O HOH C2105 2405 3779 5155 -601 -1310 1300 O

HETATM 5427 O HOH C2106 0.007 -24 554 -14.110 1 00 34.86 O

ANISOU 5427 O HOH C2106 3864 4510 4870 399 91 -95 O

HETATM 5428 O HOH C2107 -4.676 -29 189 -10.480 1 00 29.05 O

ANISOU 5428 O HOH C2107 2259 4073 4704 -196 -531 -904 O

HETATM 5429 O HOH C2108 0.972 -37 641 -14.019 1 00 18.71 O

ANISOU 5429 O HOH C2108 2514 2817 1775 20 985 48 O

HETATM 5430 O HOH C2109 -0.254 -34 217 -15.400 1 00 24.09 O

ANISOU 5430 O HOH C2109 2581 3158 3414 37 -1251 -23 O

HETATM 5431 O HOH C2110 4.116 -39 288 -7.513 1 00 21.40 O

ANISOU 5431 0 HOH C2110 1641 3122 3365 -427 807 -368 O

HETATM 5432 0 HOH C2111 4.784 -34 888 -12.941 1 00 34.03 O

ANISOU 5432 0 HOH C2111 5071 4395 3461 -1462 537 -897 O

HETATM 5433 0 HOH C2112 -0.082 -39 329 -9.520 1 00 16.84 O

ANISOU 5433 0 HOH C2112 2474 2151 1770 -202 533 -256 O

HETATM 5434 0 HOH C2113 -1.151 -40 968 -3.491 1 00 27.03 O

ANISOU 5434 0 HOH C2113 3161 3182 3924 -106 -558 -382 O

HETATM 5435 0 HOH C2114 -3.238 -39 722 -6.578 1 00 22.09 O

ANISOU 5435 0 HOH C2114 3415 2973 2003 -156 250 -754 O

HETATM 5436 0 HOH C2115 -4.758 -36 057 -6.206 1 00 14.41 O

ANISOU 5436 0 HOH C2115 1576 2370 1527 -137 237 -188 O

HETATM 5437 0 HOH C2116 0.422 -41 818 -0.663 1 00 23.36 O

ANISOU 5437 0 HOH C2116 2616 3370 2889 -428 26 247 O

HETATM 5438 0 HOH C2117 -3.351 -41 171 5.398 1 00 32.58 O

ANISOU 5438 0 HOH C2117 3446 4689 4244 -195 1377 -627 O

HETATM 5439 0 HOH C2118 2.894 -42 994 0.139 1 00 37.23 O

ANISOU 5439 0 HOH C2118 5368 4498 4277 -388 734 1373 O

HETATM 5440 0 HOH C2119 10.301 -45 140 1.093 1 00 33.36 O

ANISOU 5440 0 HOH C2119 4019 2808 5848 836 620 1246 O

HETATM 5441 0 HOH C2120 -2.502 -18 894 -13.884 1 00 27.88 O

ANISOU 5441 0 HOH C2120 1418 5251 3923 95 515 240 O

HETATM 5442 0 HOH C2121 6.399 -26 671 -18.956 1 00 35.88 O

ANISOU 5442 0 HOH C2121 4094 3825 5714 -987 136 158 O

HETATM 5443 0 HOH C2122 -2.304 -15 651 -16.956 1 00 28.10 O

ANISOU 5443 0 HOH C2122 1309 4799 4566 554 -386 920 O

HETATM 5444 0 HOH C2123 2.167 -9 130 -18.075 1 00 33.51 O

ANISOU 5444 0 HOH C2123 3932 3849 4951 345 -499 776 O

HETATM 5445 0 HOH C2124 3.390 -9 018 -14.998 1 00 26.66 O

ANISOU 5445 0 HOH C2124 1991 2039 6097 484 1589 753 O

HETATM 5446 0 HOH C2125 -4.017 -13 077 -13.543 1 00 35.08 O

ANISOU 5446 0 HOH C2125 1027 7037 5262 -732 -249 1350 O

HETATM 5447 0 HOH C2126 3.705 -38 895 12.544 1 00 35.86 O

ANISOU 5447 0 HOH C2126 4608 4496 4521 -1602 292 1767 O

HETATM 5448 0 HOH C2127 21.479 -9 553 -32.278 1 00 28.79 O

ANISOU 5448 0 HOH C2127 2719 4627 3592 406 282 937 O

CONECT 86 344

CONECT 139 1936

CONECT 241 5028

CONECT 242 5028 CONECT 256 5028

CONECT 261 5028

CONECT 274 5028

CONECT 276 3493

CONECT 297 5028

CONECT 344 86

CONECT 402 1639

CONECT 930 1273

CONECT 1273 930

CONECT 1639 402

CONECT 1746 2007

CONECT 1799 3639

CONECT 1901 5037

CONECT 1902 5037

CONECT 1916 5037

CONECT 1921 5037

CONECT 1934 5037

CONECT 1936 139

CONECT 1960 5037

CONECT 2007 1746

CONECT 2061 3326

CONECT 2612 2959

CONECT 2959 2612

CONECT 3326 2061

CONECT 3440 3710

CONECT 3493 276

CONECT 3595 5046

CONECT 3596 5046

CONECT 3610 5046

CONECT 3615 5046

CONECT 3624 5046

CONECT 3637 5046

CONECT 3639 1799

CONECT 3663 5046

CONECT 3710 3440

CONECT 3768 5006

CONECT 4295 4639

CONECT 4639 4295

CONECT 5006 3768

CONECT 5028 241 242 256 261

CONECT 5028 274 297 5087

CONECT 5029 5030 5031 5032

CONECT 5030 5029

CONECT 5031 5029

CONECT 5032 5029

CONECT 5033 5034 5035 5036

CONECT 5034 5033

CONECT 5035 5033

CONECT 5036 5033

CONECT 5037 1901 1902 1916

CONECT 5037 1934 1960 5069

CONECT 5038 5039 5040 5041

CONECT 5039 5038

CONECT 5040 5038

CONECT 5041 5038

CONECT 5042 5043 5044 5045

CONECT 5043 5042

CONECT 5044 5042

CONECT 5045 5042

CONECT 5046 3595 3596 3610

CONECT 5046 3624 3637 3663 CONECT 5047 5048 5049 5050

CONECT 5048 5047

CONECT 5049 5047

CONECT 5050 5047

CONECT 5069 5037

CONECT 5087 5028

CONECT 5223 5046

MASTER 549 0 8 15 45 0 18 6 5445 3 72 60

END

Table B. Atomic coordinates of the crystal of form I

HEADER STRUCTURAL PROTEIN 4AK3

TITLE CRYSTAL STRUCTURE OF HUMAN FIBRILLAR PROCOLLAGEN TYPE III C-

TITLE 2 PROPEPTIDE TRIMER

COMPND MOL ID: 1;

COMPND 2 MOLECULE: COLLAGEN ALPHA-1 (III) CHAIN;

COMPND 3 CHAIN: A;

COMPND 4 FRAGMENT: CPROPEPTIDE, RESIDUES 919-1163;

COMPND 5 SYNONYM: PROCOLLAGEN III;

COMPND 6 ENGINEERED: YES;

COMPND 7 MUTATION: YES

SOURCE MOL ID: 1;

SOURCE 2 ORGANISM SCIENTIFIC: HOMO SAPIENS;

SOURCE 3 ORGANISM COMMON: HUMAN;

SOURCE 4 ORGANISM TAXID : 9606;

SOURCE 5 EXPRESSION SYSTEM: HOMO SAPIENS;

SOURCE 6 EXPRESSION SYSTEM COMMON: HUMAN;

SOURCE 7 EXPRESSION SYSTEM TAXID : 9606;

SOURCE 8 EXPRESSION SYSTEM CELL LINE: HEK293T;

SOURCE 9 EXPRESSION SYSTEM PLASMID: PHLSEC

KEYWDS STRUCTURAL PROTEIN, FIBRILLAR COLLAGEN, EXTACELLULAR MATRIX,

FIBROSIS

EXPDTA X-RAY DIFFRACTION

AUTHOR J. M. BOURHIS, N.MARIANO, Y . ZHAO, K . HARLOS , E . Y . JONES , C . MOALI , N . AGHAJARI ,

AUTHOR 2 D. J. S . HULMES

REVDAT 1 22-FEB-12 4AK3 0

JRNL AUTH J. M. BOURHIS, N.MARIANO, Y . ZHAO, K . HARLOS , E . Y . JONES , C . MOALI ,

JRNL AUTH 2 N.AGHAJARI, D. J. S . HULMES

JRNL TITL STRUCTURAL BASIS OF FIBRILLAR PROCOLLAGEN TRIMERIZATION AND

JRNL TITL 2 ASSOCIATED TISSUE DISORDERS

JRNL REF TO BE PUBLISHED

JRNL REFN

REMARK 1

REMARK 1 REFERENCE 1

REMARK 1 AUTH J. M. BOURHIS, N.MARIANO, Y . ZHAO, T . S .WALTER, K. HARLOS, C .MOALI,

REMARK 1 AUTH 2 D. J. S . HULMES, N.AGHAJARI

REMARK 1 TITL LARGE SCALE PRODUCTION AND CRYSTALLISATION OF THE

REMARK 1 TITL 2 C-PROPEPTIDE TRIMER FROM PROCOLLAGEN III FOR HIGH

REMARK 1 TITL 3 RESOLUTION STRUCTURE DETERMINATION

REMARK 1 REF TO BE PUBLISHED

REMARK 1 REFN

REMARK 2

REMARK 2 RESOLUTION. 3.50 ANGSTROMS.

REMARK 3

REMARK 3 REFINEMENT .

REMARK 3 PROGRAM : REFMAC 5.6.0116

REMARK 3 AUTHORS : MURSHUDOV, VAGIN, DODSON

REMARK 3

REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD

REMARK 3

REMARK 3 DATA USED IN REFINEMENT.

REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) 3.50

REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) 43.02

REMARK 3 DATA CUTOFF (SIGMA(F)) NONE

REMARK 3 COMPLETENESS FOR RANGE (%) 99.40

REMARK 3 NUMBER OF REFLECTIONS 3954

REMARK 3

REMARK 3 FIT TO DATA USED IN REFINEMENT.

REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT

REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM REMARK R VALUE (WORKING + TEST SET) 0.28538

REMARK R VALUE (WORKING SET) 0.28276

REMARK FREE R VALUE 0.33715

REMARK FREE R VALUE TEST SET SIZE (%) 4.6

REMARK FREE R VALUE TEST SET COUNT 192

REMARK REMARK FIT IN THE HIGHEST RESOLUTION BIN.

REMARK TOTAL NUMBER OF BINS USED 20

REMARK BIN RESOLUTION RANGE HIGH (A) 3.501

REMARK BIN RESOLUTION RANGE LOW (A) 3.591

REMARK REFLECTION IN BIN (WORKING SET) 257

REMARK BIN COMPLETENESS (WORKING+TEST) (%) 99.62

REMARK BIN R VALUE (WORKING SET) 0.357

REMARK BIN FREE R VALUE SET COUNT 8

REMARK BIN FREE R VALUE 0.320

REMARK REMARK NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.

REMARK PROTEIN ATOMS 1553

REMARK NUCLEIC ACID ATOMS 0

REMARK HETEROGEN ATOMS 1

REMARK SOLVENT ATOMS 1

REMARK REMARK B VALUES.

REMARK FROM WILSON PLOT (A**2) NULL

REMARK MEAN B VALUE (OVERALL, A**2) 70.734

REMARK OVERALL ANISOTROPIC B VALUE.

REMARK Bll (A**2) 0 .02

REMARK B22 (A**2) 0 .02

REMARK B33 (A**2) - 0.04

REMARK B12 (A**2) 0 .01

REMARK B13 (A**2) 0 .00

REMARK B23 (A**2) 0 .00

REMARK REMARK ESTIMATED OVERALL COORDINATE ERROR.

REMARK ESU BASED ON R VALUE (A) NULL REMARK ESU BASED ON FREE R VALUE (A) 0.759 REMARK ESU BASED ON MAXIMUM LIKELIHOOD (A) 0.716 REMARK ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A' *2) 97.657 REMARK REMARK CORRELATION COEFFICIENTS.

REMARK CORRELATION COEFFICIENT FO-FC : 0.919

REMARK CORRELATION COEFFICIENT FO-FC FREE : 0.776

REMARK REMARK RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK BOND LENGTHS REFINED ATOMS (A) 1619 ; 0.010 ; 0.019 REMARK BOND LENGTHS OTHERS (A) NULL NULL NULL REMARK BOND ANGLES REFINED ATOMS (DEGREES) 2222 ; 1.432 ; 1.926 REMARK BOND ANGLES OTHERS (DEGREES) NULL NULL NULL REMARK TORSION ANGLES, PERIOD 1 (DEGREES) 223 ; 6.291 ; 5.000 REMARK TORSION ANGLES, PERIOD 2 (DEGREES) 62 ;36.759 ; 24.032 REMARK TORSION ANGLES, PERIOD 3 (DEGREES) 179 ; 15.779 ;15.000 REMARK TORSION ANGLES, PERIOD 4 (DEGREES) 6 ;23.008 ;15.000 REMARK CHIRAL-CENTER RESTRAINTS (A **3) 244 ; 0.078 ; 0.200 REMARK GENERAL PLANES REFINED ATOMS (A) 1289 ; 0.011 ; 0.021 REMARK GENERAL PLANES OTHERS (A) NULL NULL NULL REMARK NON-BONDED CONTACTS REFINED ATOMS (A) NULL NULL NULL REMARK NON-BONDED CONTACTS OTHERS (A) NULL NULL NULL REMARK NON-BONDED TORSION REFINED ATOMS (A) NULL NULL NULL REMARK NON-BONDED TORSION OTHERS (A) NULL NULL NULL REMARK H-BOND (X...Y) REFINED ATOMS (A) NULL NULL NULL REMARK H-BOND (X...Y) OTHERS (A) NULL NULL NULL REMARK 3 POTENTIAL METAL-ION REFINED ATOMS NULL ; NULL ; NULL REMARK 3 POTENTIAL METAL-ION OTHERS NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW REFINED ATOMS NULL ; NULL ; NULL REMARK 3 SYMMETRY VDW OTHERS NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND REFINED ATOMS NULL ; NULL ; NULL REMARK 3 SYMMETRY H-BOND OTHERS NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION REFINED ATOMS NULL ; NULL ; NULL REMARK 3 SYMMETRY METAL-ION OTHERS NULL ; NULL ; NULL REMARK 3

REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2) NULL ; NULL ; NULL REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2) NULL ; NULL ; NULL REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2) NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2) NULL ; NULL ; NULL REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2) NULL ; NULL ; NULL REMARK 3

REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 RIGID-BOND RESTRAINTS (A**2) NULL ; NULL ; NULL REMARK 3 SPHERICITY; FREE ATOMS (A**2) NULL ; NULL ; NULL REMARK 3 SPHERICITY; BONDED ATOMS (A**2) NULL ; NULL ; NULL REMARK 3

REMARK 3 NCS RESTRAINTS STATISTICS

REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL

REMARK 3

REMARK 3 TLS DETAILS

REMARK 3 NUMBER OF TLS GROUPS 1

REMARK 3

REMARK 3 TLS GROUP : 1

REMARK 3 NUMBER OF COMPONENTS GROUP

REMARK 3 COMPONENTS C SSSEQI C SSSEQI

REMARK 3 RESIDUE RANGE : A 14 A 247

REMARK 3 ORIGIN FOR THE GROUP (A) : 24.1330 17.6626 0.1744

REMARK 3 T TENSOR

REMARK 3 Til : 0 2483 T22 : 0 2227

REMARK 3 T33: 0 4328 T12 : 0 0373

REMARK 3 T13 : 0 0450 T23: -0 0228

REMARK 3 L TENSOR

REMARK 3 Lll 5 2604 L22 2 5658

REMARK 3 L33 6 8709 L12 -1 0753

REMARK 3 L13 -2 7492 L23 1 3016

REMARK 3 TENSOR

REMARK 3 Sll -0 4975 S12 -0 1981 S13: -0 7822

REMARK 3 S21 0 4534 S22 0 2466 S23: 0 4391

REMARK 3 S31 0 5723 S32 -0 2731 S33: 0 2509

REMARK 3

REMARK 3 BULK SOLVENT MODELLING.

REMARK 3 METHOD USED : MASK

REMARK 3 PARAMETERS FOR MASK CALCULATION

REMARK 3 VDW PROBE RADIUS 1.20

REMARK 3 ION PROBE RADIUS 0.80

REMARK 3 SHRINKAGE RADIUS 0.80

REMARK 3

REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE REMARK 3 RIDING POSITIONS.

REMARK 3 HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT

REMARK 4

REMARK 4 4AK3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-ll

REMARK 100

REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 21-FEB-12.

REMARK 100 THE PDBE ID CODE IS EBI-50918.

REMARK 200 REMARK 200 EXPERIMENTAL DETAILS

REMARK 200 EXPERIMENT TYPE X-RAY DIFFRACTION

REMARK 200 DATE OF DATA COLLECTION 16-MAY-ll

REMARK 200 TEMPERATURE (KELVIN) 100

REMARK 200 PH NULL

REMARK 200 NUMBER OF CRYSTALS USED 1

REMARK 200

REMARK 200 SYNCHROTRON (Y/N) Y

REMARK 200 RADIATION SOURCE DIAMOND

REMARK 200 BEAMLINE 103

REMARK 200 X-RAY GENERATOR MODEL NULL

REMARK 200 MONOCHROMATIC OR LAUE (M/L) M

REMARK 200 WAVELENGTH OR RANGE (A) 0.976

REMARK 200 MONOCHROMATOR NULL

REMARK 200 OPTICS NULL

REMARK 200

REMARK 200 DETECTOR TYPE CCD

REMARK 200 DETECTOR MANUFACTURER ADSC

REMARK 200 INTENSITY-INTEGRATION SOFTWARE MOSFLM

REMARK 200 DATA SCALING SOFTWARE SCALA

REMARK 200

REMARK 200 NUMBER OF UNIQUE REFLECTIONS 4149

REMARK 200 RESOLUTION RANGE HIGH (A) 3.50

REMARK 200 RESOLUTION RANGE LOW (A) 43.03

REMARK 200 REJECTION CRITERIA (SIGMA(I)) 3.2

REMARK 200

REMARK 200 OVERALL .

REMARK 200 COMPLETENESS FOR RANGE (%) 99.7

REMARK 200 DATA REDUNDANCY 7.9

REMARK 200 R MERGE (I) 0.10

REMARK 200 R SYM (I) NULL

REMARK 200 <I/SIGMA(I)> FOR THE DATA SET 10.70

REMARK 200

REMARK 200 IN THE HIGHEST RESOLUTION SHELL

REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) 3.50

REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) 3.63

REMARK 200 COMPLETENESS FOR SHELL (%) 99.8

REMARK 200 DATA REDUNDANCY IN SHELL 8.2

REMARK 200 R MERGE FOR SHELL (I) 0.64

REMARK 200 R SYM FOR SHELL (I) NULL

REMARK 200 <I/SIGMA(I)> FOR SHELL 3.20

REMARK 200

REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH

REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT

REMARK 200 SOFTWARE USED: MOLREP

REMARK 200 STARTING MODEL: PDB ENTRY 4AE2

REMARK 200

REMARK 200 REMARK : NONE

REMARK 280

REMARK 280 CRYSTAL

REMARK 280 SOLVENT CONTENT, VS (%) : 56.5

REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS ** 3 /DA) : 2.83

REMARK 280

REMARK 280 CRYSTALLIZATION CONDITIONS: NULL

REMARK 290

REMARK 290 CRYSTALLOGRAPHIC SYMMETRY

REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 3 2 1

REMARK 290

REMARK 290 SYMOP SYMMETRY

REMARK 290 NNNMMM OPERATOR

REMARK 290 1555 Χ,Υ,Ζ REMARK 290 2555 -Y ,X-Y, z

REMARK 290 3555 -X+Y, -X, Z

REMARK 290 4555 Y, X, -z

REMARK 290 5555 X- Y, -Y, -z

REMARK 290 6555 -X , -X+Y, -. z

REMARK 290

REMARK 290 WHERE NNN > OPERATOR NUMBER

REMARK 290 MMM > TRANSLATION VECTOR

REMARK 290

REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS

REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM

REMARK 290 RECORDS IN THIS ENTRY ¹ TO PRODUCE CRYSTALLOGRAPHICALLY

REMARK 290 RELATED MOLECULES.

REMARK 290 SMTRY1 1 1 .000000 0.000000 0.000000 0. 00000

REMARK 290 SMTRY2 1 0 .000000 1.000000 0.000000 0. 00000

REMARK 290 SMTRY3 1 0 .000000 0.000000 1.000000 0. 00000

REMARK 290 SMTRY1 2 -0 .500000 -0.866025 0.000000 0. 00000

REMARK 290 SMTRY2 2 0 .866025 -0.500000 0.000000 0. 00000

REMARK 290 SMTRY3 2 0 .000000 0.000000 1.000000 0. 00000

REMARK 290 SMTRY1 3 -0 .500000 0.866025 0.000000 0. 00000

REMARK 290 SMTRY2 3 -0 .866025 -0.500000 0.000000 0. 00000

REMARK 290 SMTRY3 3 0 .000000 0.000000 1.000000 0. 00000

REMARK 290 SMTRY1 4 -0 .500000 0.866025 0.000000 0. 00000

REMARK 290 SMTRY2 4 0 .866025 0.500000 0.000000 0. 00000

REMARK 290 SMTRY3 4 0 .000000 0.000000 -1.000000 0. 00000

REMARK 290 SMTRY1 5 1 .000000 0.000000 0.000000 0. 00000

REMARK 290 SMTRY2 5 0 .000000 -1.000000 0.000000 0. 00000

REMARK 290 SMTRY3 5 0 .000000 0.000000 -1.000000 0. 00000

REMARK 290 SMTRY1 6 -0 .500000 -0.866025 0.000000 0. 00000

REMARK 290 SMTRY2 6 -0 .866025 0.500000 0.000000 0. 00000

REMARK 290 SMTRY3 6 0 .000000 0.000000 -1.000000 0. 00000

REMARK 290

REMARK 290 REMARK: NULL

REMARK 300

REMARK 300 BIOMOLECULE : 1

REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM

REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN

REMARK 300 THIS ENTRY . THE REMARK MAY ALSO PROVIDE INFORMATION ON

REMARK 300 BURIED SURFACE . AREA.

REMARK 350

REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN

REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE

REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS

REMARK 350 GIVEN BELOW. BOTH NON -CRYSTALLOGRAPHIC AND

REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE i GIVEN.

REMARK 350

REMARK 350 BIOMOLECULE : 1

REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC

REMARK 350 SOFTWARE USED: PISA

REMARK 350 TOTAL BURIED SURFACE AREA: 3310 . ANGSTROM** 2

REMARK 350 SURFACE AREA OF THE COMPLEX: 30290 ANGSTROM* * 2

REMARK 350 CHANGE IN SOLVENT FREE ENERGY: - 72.3 KCAL/MOL

REMARK 350 APPLY THE FOLLOWING TO CHAINS: A

REMARK 350 BIOMT1 1 1 .000000 0.000000 0.000000 0. 00000

REMARK 350 BIOMT2 1 0 .000000 1.000000 0.000000 0. 00000

REMARK 350 BIOMT3 1 0 .000000 0.000000 1.000000 0. 00000

REMARK 350 BIOMT1 2 -0 .500000 0.866025 0.000000 43. 02350

REMARK 350 BIOMT2 2 -0 .866025 -0.500000 0.000000 74. 51889

REMARK 350 BIOMT3 2 0 .000000 0.000000 1.000000 0. 00000

REMARK 350 BIOMT1 3 -0 .500000 -0.866025 0.000000 86. 04700

REMARK 350 BIOMT2 3 0 .866025 -0.500000 0.000000 0. 00000 REMARK 350 BIOMT3 0.000000 0.000000 1.000000 0.00000 REMARK 400

REMARK 400 COMPOUND

REMARK 400 ENGINEERED RESIDUE IN CHAIN A, ASN1064 TO GLN

REMARK 465

REMARK 465 MISSING RESIDUES

REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE

REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465

REMARK 465 M RES C SSSEQI

REMARK 465 GLU A -10

REMARK 465 THR A -9

REMARK 465 GLY A -8

REMARK 465 HIS A -7

REMARK 465 HIS A -6

REMARK 465 HIS A -5

REMARK 465 HIS A -4

REMARK 465 HIS A -3

REMARK 465 HIS A -2

REMARK 465 SER A -1

REMARK 465 ALA A 0

REMARK 465 ASP A 1

REMARK 465 GLU A 2

REMARK 465 PRO A 3

REMARK 465 MET A 4

REMARK 465 ASP A 5

REMARK 465 PHE A 6

REMARK 465 LYS A 7

REMARK 465 ILE A 8

REMARK 465 ASN A 9

REMARK 465 THR A 10

REMARK 465 ASP A 11

REMARK 465 GLU A 12

REMARK 465 ILE A 13

REMARK 465 ASP A 112

REMARK 465 GLY A 113

REMARK 465 ASN A 175

REMARK 465 GLU A 176

REMARK 465 GLU A 202

REMARK 470

REMARK 470 MISSING ATOM

REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE

REMARK 470 M RES CSSEQI ATOMS

REMARK 470 MET A 14 CG SD CE

REMARK 470 THR A 15 OG1 CG2

REMARK 470 SER A 16 OG

REMARK 470 LEU A 17 CG CD1 CD2

REMARK 470 LYS A 18 CD CE NZ

REMARK 470 SER A 19 OG

REMARK 470 VAL A 20 CGI CG2

REMARK 470 LYS A 35 CG CD CE NZ

REMARK 470 ARG A 39 CG CD NE CZ NH1 NH2

REMARK 470 ASN A 40 CG OD1 ND2

REMARK 470 ARG A 42 CG CD NE CZ NH1 NH2

REMARK 470 LEU A 44 CG CD1 CD2

REMARK 470 LYS A 45 CG CD CE NZ

REMARK 470 PHE A 46 CG CD1 CD2 CE1 CE2 CZ

REMARK 470 LEU A 51 CG CD1 CD2 REMARK 470 LYS A 52 CG CD CE NZ

REMARK 470 GLU A 55 CG CD OE1 OE2

REMARK 470 LYS A 65 CG CD CE NZ

REMARK 470 LEU A 66 CG CD1 CD2

REMARK 470 LYS A 70 CG CD CE NZ

REMARK 470 LEU A 87 CG CD1 CD2

REMARK 470 LYS A 92 CG CD CE NZ

REMARK 470 HIS A 93 CG ND1 CD2 CE1 NE2

REMARK 470 ASP A 97 CG OD1 OD2

REMARK 470 GLU A 101 CG CD OE1 OE2

REMARK 470 LYS A 102 CG CD CE NZ

REMARK 470 LYS A 103 CG CD CE NZ

REMARK 470 VAL A 105 CGI CG2

REMARK 470 GLU A 109 CG CD OE1 OE2

REMARK 470 MET A 111 CG SD CE

REMARK 470 GLU A 123 CG CD OE1 OE2

REMARK 470 GLU A 126 CG CD OE1 OE2

REMARK 470 LEU A 129 CG CD1 CD2

REMARK 470 GLN A 132 CG CD OE1 NE2

REMARK 470 LEU A 133 CG CD1 CD2

REMARK 470 PHE A 135 CG CD1 CD2 CE1 CE2

REMARK 470 LEU A 136 CG CD1 CD2

REMARK 470 LEU A 138 CG CD1 CD2

REMARK 470 SER A 141 OG

REMARK 470 ARG A 142 CG CD NE CZ NH1 NH2

REMARK 470 TYR A 149 CG CD1 CD2 CE1 CE2 CZ OH

REMARK 470 LYS A 152 CB CG CD CE NZ

REMARK 470 ASN A 153 CB CG OD1 ND2

REMARK 470 ALA A 156 CB

REMARK 470 MET A 158 CG SD CE

REMARK 470 GLN A 160 CG CD OE1 NE2

REMARK 470 ASN A 164 CG OD1 ND2

REMARK 470 LYS A 166 CG CD CE NZ

REMARK 470 LYS A 167 CG CD CE NZ

REMARK 470 MET A 172 CG SD CE

REMARK 470 ASN A 184 CG OD1 ND2

REMARK 470 SER A 185 OG

REMARK 470 LYS A 186 CG CD CE NZ

REMARK 470 LYS A 198 CG CD CE NZ

REMARK 470 THR A 200 OG1 CG2

REMARK 470 LYS A 205 CG CD CE NZ

REMARK 470 ARG A 213 CG CD NE CZ NH1 NH2

REMARK 470 LYS A 214 CG CD CE NZ

REMARK 470 TYR A 226 CG CD1 CD2 CE1 CE2 CZ OH

REMARK 470 ILE A 228 CGI CG2 CD1

REMARK 470 ASP A 232 CG OD1 OD2

REMARK 470 GLN A 233 CG CD OE1 NE2

REMARK 470 GLU A 234 CG CD OE1 OE2

REMARK 470 ASP A 238 CG OD1 OD2

REMARK 500

REMARK 500 GEOMETRY AND I STEREOCHEMISTRY

REMARK 500 SUBTOPIC : CLOSE CONTACTS IN SAME ASYMMET:

REMARK 500

REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT

REMARK 500

REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE

REMARK 500 0 GLN ^■ A 23 OG SER A 26 2.16

REMARK 500 CB ASP A 97 O GLY A 229 2.18

REMARK 500 OG : SER . A 99 O GLU A 101 2.05

REMARK 500 0 CYS A 151 CA TRP A 203 2.08

REMARK 500 0 CYS A 151 N SER A 204 2.15 REMARK 500 CH2 TRP A 203 CB GLU A 234 1.96

REMARK 500

REMARK 500 REMARK: NULL

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: TORSION ANGLES

REMARK 500

REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:

REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;

REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE) .

REMARK 500

REMARK 500 STANDARD TABLE:

REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)

REMARK 500

REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996) . PHI/PSI-

REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400

REMARK 500

REMARK 500 M RES CSSEQI PSI PHI

REMARK 500 GLN A 62 -128.14 51.55

REMARK 500 TYR A 157 -70.41 -135.84

REMARK 500

REMARK 500 REMARK : NULL

REMARK 620

REMARK 620 METAL COORDINATION

REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;

REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE) :

REMARK 620

REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL

REMARK 620 CA A 246 CA

REMARK 620 N RES CSSEQI ATOM

REMARK 620 1 ASP A 59 OD1

REMARK 620 2 ASP A 59 OD2 50 .2

REMARK 620 3 ASP A 67 OD1 99 .7 125. 4

REMARK 620 4 GLN A 62 O 96 .3 61. 0 162 .1

REMARK 620 5 CYS A 64 O 114 .2 67. 8 98 .8 67. 1

REMARK 620 6 HOH A2001 O 151 .3 145. 7 84 .2 85. 6 93.1

REMARK 620 7 ASN A 61 OD1 77 .8 101. 3 116 .5 74. 7 140.8 75.1

REMARK 620 N 1 2 3 4 5 6

REMARK 800

REMARK 800 SITE

REMARK 800 S ITE_IDENTIFIER : AC1

REMARK 800 EVIDENCE_CODE : SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SITE FOR RESIDUE CA A 246

REMARK 900

REMARK 900 RELATED ENTRIES

REMARK 900 RELATED ID: 2V53 RELATED DB : PDB

REMARK 900 CRYSTAL STRUCTURE OF A SPARC- -COLLAGEN COMPLEX

REMARK 900 RELATED ID: 4AE2 RELATED DB : PDB

REMARK 900 CRYSTAL STRUCTURE OF HUMAN FI IBRILLAR PROCOLLAGEN

REMARK 900 III C-PROPEPTIDE TRIMER

REMARK 900 RELATED ID: 4AEJ RELATED DB : PDB

REMARK 900 CRYSTAL STRUCTURE OF HUMAN FIBRILLAR PROCOLLAGEN

REMARK 900 III C-PROPEPTIDE TRIMER

DBREF 4AK3 A 1 245 UNP P02461 C03A1 HUMAN 919 1163

SEQADV 4AK3 GLU A 10 UNP P02461 EXPRESSION TAG

SEQADV 4AK3 THR A -9 UNP P02461 EXPRESSION TAG

SEQADV 4AK3 GLY A -8 UNP P02461 EXPRESSION TAG

SEQADV 4AK3 HIS A -7 UNP P02461 EXPRESSION TAG

SEQADV 4AK3 HIS A -6 UNP P02461 EXPRESSION TAG

SEQADV 4AK3 HIS A -5 UNP P02461 EXPRESSION TAG

SEQADV 4AK3 HIS A -4 UNP P02461 EXPRESSION TAG SEQADV 4AK3 HIS A UNP P02461 EXPRESSION TAG

SEQADV 4AK3 HIS A -2 UNP P02461 EXPRESSION TAG

SEQADV 4AK3 SER A -1 UNP P02461 EXPRESSION TAG

SEQADV 4AK3 ALA A 0 UNP ¹ P02461 EXPRESSION TAG

SEQADV 4AK3 GLN A 132 UNP ¹ P02461 HIS 1050 CONFLICT

SEQADV 4AK3 GLN A 146 UNP ¹ P02461 ASN 1064 ENGINEERED MUTATION

SEQRES 1 A 256 GLU THR GLY HIS HIS HIS HIS HIS HIS SER ALA ASP GLU

SEQRES 2 A 256 PRO MET ASP PHE LYS ILE ASN THR ASP GLU ILE MET THR

SEQRES A 256 SER LEU LYS SER VAL ASN GLY GLN ILE GLU SER LEU ILE

SEQRES 4 A 256 SER PRO ASP GLY SER ARG LYS ASN PRO ALA ARG ASN CYS

SEQRES 5 A 256 ARG ASP LEU LYS PHE CYS HIS PRO GLU LEU LYS SER GLY

SEQRES 6 A 256 GLU TYR TRP VAL ASP PRO ASN GLN GLY CYS LYS LEU ASP

SEQRES 7 A 256 ALA ILE LYS VAL PHE CYS ASN MET GLU THR GLY GLU THR

SEQRES 8 A 256 CYS ILE SER ALA ASN PRO LEU ASN VAL PRO ARG LYS HIS

SEQRES 9 A 256 TRP TRP THR ASP SER SER ALA GLU LYS LYS HIS VAL TRP

SEQRES 10 A 256 PHE GLY GLU SER MET ASP GLY GLY PHE GLN PHE SER TYR

SEQRES 11 A 256 GLY ASN PRO GLU LEU PRO GLU ASP VAL LEU ASP VAL GLN

SEQRES 12 A 256 LEU ALA PHE LEU ARG LEU LEU SER SER ARG ALA SER GLN

SEQRES 13 A 256 GLN ILE THR TYR HIS CYS LYS ASN SER ILE ALA TYR MET

SEQRES 14 A 256 ASP GLN ALA SER GLY ASN VAL LYS LYS ALA LEU LYS LEU

SEQRES 15 A 256 MET GLY SER ASN GLU GLY GLU PHE LYS ALA GLU GLY ASN

SEQRES 16 A 256 SER LYS PHE THR TYR THR VAL LEU GLU ASP GLY CYS THR

SEQRES 17 A 256 LYS HIS THR GLY GLU TRP SER LYS THR VAL PHE GLU TYR

SEQRES 18 A 256 ARG THR ARG LYS ALA VAL ARG LEU PRO ILE VAL ASP ILE

SEQRES 19 A 256 ALA PRO TYR ASP ILE GLY GLY PRO ASP GLN GLU PHE GLY

SEQRES 20 A 256 VAL ASP VAL GLY PRO VAL CYS PHE LEU

HET CA A 246 1

HETNAM CA CALCIUM ION

FORMUL 2 CA CA 2+

FORMUL 3 HOH *1 (H2 O)

HELIX 1 1 MET A 14 SER A 29 16

HELIX 2 2 ASN A 40 HIS A 48 9

HELIX 3 3 PRO A 125 SER A 140 16

HELIX 4 4 ASN A 1 84 PHE A 187 4

HELIX 5 5 LYS A 214 LEU A 218

SHEET 1 AA 7 GLY A 54 VAL A 58

SHEET 2 AA 7 ILE A 69 CYS A 73 1 0 ILE A 69 N VAL A 58

SHEET 3 AA 7 THR A 80 ILE A 82 1 0 CYS A 81 N PHE A 72

SHEET 4 AA 7 GLU A 234 LEU A 245 1 0 VAL A 242 N ILE A 82

SHEET 5 AA 7 ARG A 142 LYS A 152 1 0 ARG A 142 N LEU A 245

SHEET 6 AA 7 SER A 204 THR A 212 1 0 SER A 204 N CYS A 151

SHEET 7 AA 7 THR A 190 ASP A 194 1 0 THR A 190 N GLU A 209

SHEET 1 AB 5 GLY A 54 VAL A 58 0

SHEET 2 AB 5 ILE A 69 CYS A 73 1 0 ILE A 69 N VAL A 58

SHEET 3 AB 5 THR A 80 ILE A 82 1 0 CYS A 81 N PHE A 72

SHEET 4 AB 5 GLU A 234 LEU A 245 1 0 VAL A 242 N ILE A 82

SHEET 5 AB 5 ASN A 88 LYS A 92 1 0 VAL A 89 N VAL A 237

SHEET 1 AC 2 ALA A 84 ASN A 85 0

SHEET 2 AC 2 SER A 118 TYR A 119 1 0 SER A 118 N ASN A 85

SHEET 1 AD 3 GLU A 178 LYS A 180 0

SHEET 2 AD 3 LYS A 170 MET A 172 1 0 LEU A 171 N PHE A 179

SHEET 3 AD 3 ASP A 222 ALA A 224 1 0 ASP A 222 N MET A 172

SSBOND 1 CYS A 41 CYS A 73 1555 1555 2. .02

SSBOND 2 CYS A 47 CYS A 64 1555 3665 2. .04

SSBOND 3 CYS A 81 CYS A 243 1555 1555 2 , .05

SSBOND 4 CYS A 151 CYS A 196 1555 1555 1. .84

LINK CA CA A 246 OD1 ASP A 59 1555 1555 2. .33

LINK CA CA A 246 OD2 ASP A 59 1555 1555 2. .78

LINK CA CA A 246 OD1 ASP A 67 1555 1555 1. .90

LINK CA CA A 246 O GLN A 62 1555 1555 2. .52

LINK CA CA A 246 O CYS A 64 1555 1555 2. .43 LINK CA CA A 246 O HOH A2001 1555 1555 2..38

LINK CA CA A 246 OD1 ASN A 61 1555 1555 2. .47

CISPEP 1 ASN A 85 PRO A 86 0 -2. 02

CISPEP 2 : LEU A 218 PRO A 219 0 9. 27

SITE 1 AC1 6 ASP A 59 ASN A 61 GLN A 62 CYS A 64

SITE 2 AC1 6 ASP A 67 HOH A2001

CRYST1 86 .047 86. 047 72. 952 90.00 90.00 120.00 P 3 2 1 6

0RIGX1 1.000000 0 .000000 0.000000 0. 00000

ORIGX2 0.000000 1 .000000 0.000000 0. 00000

ORIGX3 0.000000 0 .000000 1.000000 0. 00000

SCALE1 0.011622 0 .006710 0.000000 0. 00000

SCALE2 0.000000 0 .013419 0.000000 0. 00000

SCALE3 0.000000 0 .000000 0.013708 0. 00000

ATOM 1 N MET A 14 38.083 22 .502 -46 .416 1 .00131. , 17 N

ANISOU 1 N MET A 14 15919 28178 5740 955 1425 -2341 N

ATOM 2 CA MET A 14 37.305 23 .569 -45 .728 1 .00129. ,41 C

ANISOU 2 CA MET A 14 15919 27597 5654 1155 1333 -1704 C

ATOM 3 C MET A 14 36.462 22 .983 -44 .601 1 .00124. ,11 C

ANISOU 3 C MET A 14 15017 26549 5590 1043 940 -2042 C

ATOM 4 O MET A 14 36.323 23 .590 -43 .544 1 .00120. ,01 O

ANISOU 4 O MET A 14 14641 25385 5572 1001 955 -1689 O

ATOM 5 CB MET A 14 36.416 24 .314 -46 .723 1 .00135. , 64 C

ANISOU 5 CB MET A 14 16854 29098 5586 1649 1233 -1249 C

ATOM 6 N THR A 15 35.920 21 .790 -44 .825 1 .00124. , 56 N

ANISOU 6 N THR A 15 14725 26996 5605 970 619 -2750 N

ATOM 7 CA THR A 15 35.127 21 .101 -43 .811 1 .00120. ,16 C

ANISOU 7 CA THR A 15 13936 26102 5619 818 284 -3132 C

ATOM 8 C THR A 15 35.965 20 .801 -42 .576 1 .00113. , 91 C

ANISOU 8 C THR A 15 13177 24419 5686 480 450 -3223 C

ATOM 9 O THR A 15 35.498 20 .954 -41 .445 1 .00109. , 51 O

ANISOU 9 O THR A 15 12623 23336 5649 423 316 -3096 O

ATOM 10 CB THR A 15 34.529 19 .789 -44 .347 1 .00122. , 63 C

ANISOU 10 CB THR A 15 13882 26962 5749 718 -9 -3953 C

ATOM 11 N SER A 16 37.206 20 .380 -42 .801 1 .00113. , 94 N

ANISOU 11 N SER A 16 13187 24303 5802 283 743 -3443 N

ATOM 12 CA SER A 16 38.124 20 .092 -41 .703 1 .00108. , 84 C

ANISOU 12 CA SER A 16 12540 22915 5900 10 913 -3530 C

ATOM 13 C SER A 16 38.394 21 .355 -40 .892 1 .00106. ,06 C

ANISOU 13 C SER A 16 12447 22032 5820 10 1089 -2851 C

ATOM 14 O SER A 16 38.436 21 .317 -39 .664 1 .00101. ,21 O

ANISOU 14 O SER A 16 11819 20811 5826 -133 1037 -2832 O

ATOM 15 CB SER A 16 39.432 19 .510 -42 .242 1 .00110. , 53 C

ANISOU 15 CB SER A 16 12688 23228 6081 -135 1217 -3855 C

ATOM 16 N LEU A 17 38.569 22 .470 -41 .595 1 .00109. , 65 N

ANISOU 16 N LEU A 17 13157 22714 5790 173 1318 -2301 N

ATOM 17 CA LEU A 17 38.798 23 .757 -40 .952 1 .00108. , 18 C

ANISOU 17 CA LEU A 17 13274 22020 5811 164 1542 -1652 C

ATOM 18 C LEU A 17 37.592 24 .148 -40 .114 1 .00105. ,49 C

ANISOU 18 C LEU A 17 12982 21410 5689 322 1242 -1429 C

ATOM 19 O LEU A 17 37.737 24 .660 -39 .002 1 .00101. , 66 O

ANISOU 19 O LEU A 17 12612 20294 5720 195 1308 -1201 O

ATOM 20 CB LEU A 17 39.094 24 .839 -41 .988 1 .00113. , 67 C

ANISOU 20 CB LEU A 17 14280 23023 5886 342 1876 -1093 C

ATOM 21 N LYS A 18 36.403 23 .894 -40 .647 1 .00107. , 84 N

ANISOU 21 N LYS A 18 13164 22231 5579 596 913 -1528 N

ATOM 22 CA LYS A 18 35.165 24 .185 -39 .935 1 .00105. , 92 C

ANISOU 22 CA LYS A 18 12904 21849 5494 777 608 -1365 C

ATOM 23 C LYS A 18 35.073 23 .348 -38 .663 1 .00100. , 10 C

ANISOU 23 C LYS A 18 11950 20590 5493 496 427 -1784 C

ATOM 24 O LYS A 18 34.643 23 .835 -37 .617 1 .00 96. ,76 O

ANISOU 24 O LYS A 18 11611 19689 5464 508 360 -1535 O ATOM 25 CB LYS A 18 33.954 23..910 -40..828 1..00110..28 C

ANISOU 25 CB LYS A 18 13267 23202 5431 1098 271 - 1507 C

ATOM 26 CG LYS A 18 34.234 24. .040 -42. .317 1. .00116. .61 C

ANISOU 26 CG LYS A 18 14128 24737 5443 1301 399 - 1438 C

ATOM 27 N SER A 19 35.484 22. .085 -38. .761 1. .00 99. .30 N

ANISOU 27 N SER A 19 11593 20572 5563 266 371 - 2412 N

ATOM 28 CA SER A 19 35.452 21. .177 -37. .617 1. .00 94. .49 C

ANISOU 28 CA SER A 19 10807 19470 5626 25 238 - 2812 C

ATOM 29 C SER A 19 36.432 21. .621 -36. .537 1. .00 90. .34 C

ANISOU 29 C SER A 19 10429 18248 5647 -155 475 - 2568 C

ATOM 30 O SER A 19 36.133 21. .541 -35. .351 1. .00 86. .27 O

ANISOU 30 O SER A 19 9890 17256 5634 -234 365 - 2560 O

ATOM 31 CB SER A 19 35.764 19. .744 -38. .063 1. .00 95. .57 C

ANISOU 31 CB SER A 19 10698 19818 5795 -146 196 - 3519 C

ATOM 32 N VAL A 20 37.602 22. .086 -36. .964 1. .00 91. .81 N

ANISOU 32 N VAL A 20 10747 18428 5711 -231 808 - 2388 N

ATOM 33 CA VAL A 20 38.628 22. .548 -36. .036 1. .00 88. .81 C

ANISOU 33 CA VAL A 20 10459 17491 5794 -436 1052 - 2202 C

ATOM 34 C VAL A 20 38.160 23. ,798 -35. .304 1. .00 87. .35 C

ANISOU 34 C VAL A 20 10527 16922 5741 -370 1079 - 1656 C

ATOM 35 O VAL A 20 38.326 23. .924 -34. .093 1. .00 83. .50 O

ANISOU 35 O VAL A 20 10041 15924 5761 -506 1068 - 1624 O

ATOM 36 CB VAL A 20 39.953 22. .860 -36. .760 1. .00 91. .68 C

ANISOU 36 CB VAL A 20 10882 18008 5945 -557 1436 - 2129 C

ATOM 37 N ASN A 21 37.596 24. .741 -36. .045 1. .00 90. .88 N

ANISOU 37 N ASN A 21 11204 17619 5709 -133 1133 - 1219 N

ATOM 38 CA ASN A 21 37.241 25. .993 -35. .426 1. .00 90. .31 C

ANISOU 38 CA ASN A 21 11427 17137 5748 -45 1229 -682 C

ATOM 39 C ASN A 21 36.187 25. .793 -34. .354 1. .00 86. .54 C

ANISOU 39 C ASN A 21 10855 16397 5630 35 903 -749 C

ATOM 40 O ASN A 21 36.264 26. .363 -33. .275 1. .00 83. .70 O

ANISOU 40 O ASN A 21 10621 15503 5681 -61 967 -561 O

ATOM 41 CB ASN A 21 36.766 27. .001 -36. .451 1. .00 95. .48 C

ANISOU 41 CB ASN A 21 12375 18108 5793 278 1358 -166 C

ATOM 42 CG ASN A 21 36.663 28. .391 -35. .873 1. .00 95. .74 c

ANISOU 42 CG ASN A 21 12799 17615 5963 345 1588 417 c

ATOM 43 OD1 ASN A 21 37.415 28. .750 -34. .977 1. .00 93. .18 0

ANISOU 43 OD1 ASN A 21 12558 16735 6111 41 1796 441 0

ATOM 44 ND2 ASN A 21 35.730 29. .182 -36. .379 1. .00 99. .31 N

ANISOU 44 ND2 ASN A 21 13489 18252 5991 759 1560 876 N

ATOM 45 N GLY A 22 35.201 24. .966 -34. .655 1. .00 86. .89 N

ANISOU 45 N GLY A 22 10659 16842 5512 187 564 - 1051 N

ATOM 46 CA GLY A 22 34.167 24. .681 -33. .680 1. .00 83. .74 C

ANISOU 46 CA GLY A 22 10129 16245 5444 236 270 - 1154 C

ATOM 47 C GLY A 22 34.798 24. .003 -32. .489 1. .00 78. .96 C

ANISOU 47 C GLY A 22 9402 15126 5471 -69 280 - 1456 C

ATOM 48 O GLY A 22 34.457 24. ,282 -31. .352 1. .00 75. .80 O

ANISOU 48 O GLY A 22 9044 14301 5454 -92 218 - 1338 O

ATOM 49 N GLN A 23 35.737 23. .111 -32. .765 1. .00 78. .84 N

ANISOU 49 N GLN A 23 9239 15178 5537 -268 370 - 1840 N

ATOM 50 CA GLN A 23 36.377 22. .355 -31. .714 1. .00 75. .04 C

ANISOU 50 CA GLN A 23 8627 14280 5604 -488 378 - 2133 C

ATOM 51 C GLN A 23 37.106 23. .318 -30. .792 1. .00 72. .95 C

ANISOU 51 C GLN A 23 8538 13541 5637 -604 584 - 1801 C

ATOM 52 O GLN A 23 37.048 23. .201 -29. .574 1. .00 69. .50 O

ANISOU 52 O GLN A 23 8066 12708 5633 -678 508 - 1833 O

ATOM 53 CB GLN A 23 37.360 21. .364 -32. .318 1. .00 76. .30 C

ANISOU 53 CB GLN A 23 8626 14633 5731 -613 492 - 2551 C

ATOM 54 CG GLN A 23 37.992 20. .413 -31. .310 1. .00 73. .14 c

ANISOU 54 CG GLN A 23 8076 13857 5858 -756 490 - 2875 c

ATOM 55 CD GLN A 23 38.854 19. .362 -31. .988 1. .00 75. .07 c ANISOU 55 CD GLN A 23 8165 14314 6045 -807 601 -3309 C

ATOM 56 OE1 GLN A 23 38.716 19. .127 -33. .182 1. .00 78. .51 O

ANISOU 56 OE1 GLN A 23 8573 15196 6062 -755 613 - 3468 O

ATOM 57 NE2 GLN A 23 39.750 18. .731 -31. .233 1. .00 73. .26 N

ANISOU 57 NE2 GLN A 23 7831 13795 6209 -877 687 - 3503 N

ATOM 58 N ILE A 24 37.787 24. .279 -31. .395 1. .00 75. .53 N

ANISOU 58 N ILE A 24 9060 13927 5712 -634 864 - 1493 N

ATOM 59 CA ILE A 24 38.545 25. .264 -30. .644 1. .00 74. .58 C

ANISOU 59 CA ILE A 24 9110 13382 5844 -809 1112 - 1220 C

ATOM 60 C ILE A 24 37.612 26. .114 -29. .797 1. .00 73. .01 C

ANISOU 60 C ILE A 24 9108 12833 5798 -693 1019 -894 C

ATOM 61 O ILE A 24 37.901 26. .405 -28. .646 1. .00 70. .38 O

ANISOU 61 O ILE A 24 8798 12086 5858 -840 1054 -877 O

ATOM 62 CB ILE A 24 39.328 26. .186 -31. .596 1. .00 78. .69 C

ANISOU 62 CB ILE A 24 9842 14035 6022 -880 1481 -928 C

ATOM 63 CGI ILE A 24 40.218 27. .142 -30. .816 1. .00 78. .28 C

ANISOU 63 CGI ILE A 24 9934 13539 6268 -1155 1779 -737 C

ATOM 64 CG2 ILE A 24 38.374 26. .988 -32. .465 1. .00 82. .12 C

ANISOU 64 CG2 ILE A 24 10547 14676 5981 -583 1488 -512 C

ATOM 65 CD1 ILE A 24 41.284 27. .793 -31. .672 1. .00 82. .42 C

ANISOU 65 CD1 ILE A 24 10585 14182 6548 -1345 2203 -576 C

ATOM 66 N GLU A 25 36.485 26. .502 -30. .372 1. .00 74. .99 N

ANISOU 66 N GLU A 25 9485 13295 5714 -403 898 -651 N

ATOM 67 CA GLU A 25 35.548 27. .330 -29. .650 1. .00 74. .11 C

ANISOU 67 CA GLU A 25 9559 12888 5711 -231 824 -331 C

ATOM 68 C GLU A 25 35.079 26. .560 -28. .439 1. .00 69. .75 C

ANISOU 68 C GLU A 25 8785 12119 5597 -292 560 -619 C

ATOM 69 O GLU A 25 34.960 27. .108 -27. .355 1. .00 67. .62 O

ANISOU 69 O GLU A 25 8624 11429 5638 -333 584 -483 O

ATOM 70 CB GLU A 25 34.360 27. .696 -30. .533 1. .00 77. .45 C

ANISOU 70 CB GLU A 25 10071 13700 5657 161 690 -68 C

ATOM 71 CG GLU A 25 34.752 28. .188 -31. .918 1. .00 82. .41 c

ANISOU 71 CG GLU A 25 10881 14684 5748 279 916 180 c

ATOM 72 CD GLU A 25 35.085 29. .669 -31. .946 1. .00 85. .09 c

ANISOU 72 CD GLU A 25 11673 14645 6013 330 1295 735 c

ATOM 73 OE1 GLU A 25 35.183 30. .276 -30. .852 1. .00 82. .86 0

ANISOU 73 OE1 GLU A 25 11542 13800 6140 202 1397 851 0

ATOM 74 OE2 GLU A 25 35.241 30. .222 -33. .061 1. .00 89. .82 0

ANISOU 74 OE2 GLU A 25 12491 15502 6135 495 1510 1049 0

ATOM 75 N SER A 26 34.836 25. .273 -28. .614 1. .00 68. .78 N

ANISOU 75 N SER A 26 8366 12266 5500 -311 337 - 1030 N

ATOM 76 CA SER A 26 34.380 24. .474 -27. .505 1. .00 65. .20 C

ANISOU 76 CA SER A 26 7729 11593 5452 -371 128 - 1285 C

ATOM 77 C SER A 26 35.409 24. .556 -26. .400 1. .00 62. .43 C

ANISOU 77 C SER A 26 7400 10806 5515 -591 269 - 1324 C

ATOM 78 O SER A 26 35.072 24. .624 -25. .232 1. .00 59. .78 0

ANISOU 78 O SER A 26 7066 10153 5494 -602 187 - 1297 0

ATOM 79 CB SER A 26 34.213 23. .029 -27. .931 1. .00 65. .33 c

ANISOU 79 CB SER A 26 7468 11895 5461 -419 -39 - 1754 c

ATOM 80 OG SER A 26 35.474 22. .480 -28. .280 1. .00 65. .71 0

ANISOU 80 OG SER A 26 7451 11972 5542 -583 125 - 1985 0

ATOM 81 N LEU A 27 36.680 24. .544 -26. .781 1. .00 63. .44 N

ANISOU 81 N LEU A 27 7516 10973 5614 -761 482 - 1404 N

ATOM 82 CA LEU A 27 37.761 24. .557 -25. .797 1. .00 61. .50 C

ANISOU 82 CA LEU A 27 7215 10432 5719 -971 604 - 1497 C

ATOM 83 C LEU A 27 37.768 25. .818 -24. .969 1. .00 60. .95 C

ANISOU 83 C LEU A 27 7366 10001 5792 -1040 728 - 1192 C

ATOM 84 O LEU A 27 37.928 25. .761 -23. .751 1. .00 58. .48 O

ANISOU 84 O LEU A 27 6995 9418 5806 -1119 673 - 1268 0

ATOM 85 CB LEU A 27 39.123 24. .407 -26. .461 1. .00 63. .47 c

ANISOU 85 CB LEU A 27 7374 10873 5869 -1138 832 - 1637 c ATOM 86 CG LEU A 27 39.397 23..090 -27..160 1..00 64..19 C

ANISOU 86 CG LEU A 27 7238 11275 5875 -1092 760 - 2010 C

ATOM 87 CD1 LEU A 27 40.728 23. .197 -27. .875 1. .00 66. .74 C

ANISOU 87 CD1 LEU A 27 7492 11813 6051 -1239 1031 - 2085 C

ATOM 88 CD2 LEU A 27 39.438 21. .976 -26. .133 1. .00 61. .37 C

ANISOU 88 CD2 LEU A 27 6689 10731 5899 -1070 595 - 2302 C

ATOM 89 N ILE A 28 37.610 26. .956 -25. .635 1. .00 63. .72 N

ANISOU 89 N ILE A 28 7990 10340 5882 -1000 916 -849 N

ATOM 90 CA ILE A 28 37.580 28. .236 -24. .951 1. .00 64. .06 C

ANISOU 90 CA ILE A 28 8308 9982 6049 -1066 1090 -558 C

ATOM 91 C ILE A 28 36.393 28. .304 -24. .017 1. .00 61. .70 C

ANISOU 91 C ILE A 28 8047 9474 5920 -871 863 -481 C

ATOM 92 O ILE A 28 36.512 28. .757 -22. .885 1. .00 60. .13 O

ANISOU 92 O ILE A 28 7911 8932 6004 -979 898 -474 O

ATOM 93 CB ILE A 28 37.494 29. .397 -25. .940 1. .00 68. .22 C

ANISOU 93 CB ILE A 28 9181 10500 6238 -989 1364 -156 C

ATOM 94 CGI ILE A 28 38.782 29. .466 -26. .772 1. .00 70. .95 c

ANISOU 94 CGI ILE A 28 9506 11015 6435 -1243 1663 -213 c

ATOM 95 CG2 ILE A 28 37.240 30. .701 -25. .199 1. .00 68. .92 c

ANISOU 95 CG2 ILE A 28 9609 10098 6478 -1008 1549 145 c

ATOM 96 CD1 ILE A 28 38.709 30. .410 -27. .943 1. .00 75. .66 c

ANISOU 96 CD1 ILE A 28 10441 11677 6628 -1138 1951 191 c

ATOM 97 N SER A 29 35.246 27. .860 -24. .499 1. .00 61. .83 N

ANISOU 97 N SER A 29 8003 9742 5747 -593 635 -450 N

ATOM 98 CA SER A 29 34.085 27. .742 -23. .641 1. .00 59. .73 C

ANISOU 98 CA SER A 29 7696 9356 5643 -417 408 -430 C

ATOM 99 C SER A 29 33.497 26. .358 -23. .763 1. .00 58. .32 C

ANISOU 99 C SER A 29 7202 9475 5482 -359 128 -750 C

ATOM 100 O SER A 29 33.122 25. .930 -24. .844 1. .00 60. .36 O

ANISOU 100 O SER A 29 7367 10127 5440 -249 44 -814 0

ATOM 101 CB SER A 29 33.031 28. .755 -24. .026 1. .00 62. .19 c

ANISOU 101 CB SER A 29 8251 9673 5706 -106 426 -42 c

ATOM 102 OG SER A 29 32.567 28. .480 -25. .330 1. .00 64. .97 0

ANISOU 102 OG SER A 29 8539 10501 5643 97 342 2 0

ATOM 103 N PRO A 30 33.435 25. .635 -22. .658 1. .00 55. .27 N

ANISOU 103 N PRO A 30 6658 8902 5439 -445 5 -965 N

ATOM 104 CA PRO A 30 32.755 24. .360 -22. .656 1. .00 54. .35 C

ANISOU 104 CA PRO A 30 6290 8970 5389 -413 -213 - 1253 C

ATOM 105 C PRO A 30 31.279 24. .628 -22. .676 1. .00 55. .09 C

ANISOU 105 C PRO A 30 6366 9199 5367 -195 -375 - 1117 C

ATOM 106 O PRO A 30 30.866 25. .760 -22. .426 1. .00 55. .68 O

ANISOU 106 O PRO A 30 6637 9140 5380 -42 -319 -794 0

ATOM 107 CB PRO A 30 33.172 23. .757 -21. .337 1. .00 51. .36 c

ANISOU 107 CB PRO A 30 5828 8279 5406 -538 -231 - 1416 c

ATOM 108 CG PRO A 30 34.547 24. .291 -21. .145 1. .00 51. .31 c

ANISOU 108 CG PRO A 30 5910 8127 5459 -692 -34 - 1376 c

ATOM 109 CD PRO A 30 34.521 25. .692 -21. .679 1. .00 53. .41 c

ANISOU 109 CD PRO A 30 6427 8367 5499 -657 124 - 1052 c

ATOM 110 N ASP A 31 30.499 23. .612 -23. .017 1. .00 55. .62 N

ANISOU 110 N ASP A 31 6196 9543 5393 -180 -556 - 1378 N

ATOM 111 CA ASP A 31 29.057 23. .763 -23. .089 1. .00 56. .89 C

ANISOU 111 CA ASP A 31 6249 9943 5423 13 -728 - 1310 C

ATOM 112 C ASP A 31 28.327 22. .873 -22. .094 1. .00 55. .00 C

ANISOU 112 C ASP A 31 5815 9570 5511 -84 -845 - 1533 C

ATOM 113 O ASP A 31 27.144 22. .639 -22. .248 1. .00 56. .45 0

ANISOU 113 O ASP A 31 5806 10038 5607 -1 -997 - 1611 0

ATOM 114 CB ASP A 31 28.546 23. .525 -24. .526 1. .00 60. .58 c

ANISOU 114 CB ASP A 31 6572 10989 5456 123 -841 - 1416 c

ATOM 115 CG ASP A 31 28.827 22. .096 -25. .048 1. .00 61. .07 c

ANISOU 115 CG ASP A 31 6409 11240 5555 -107 -895 - 1903 c

ATOM 116 OD1 ASP A 31 28.577 21. .119 -24. .304 1. .00 59. .41 0 ANISOU 116 OD1 ASP A 31 6055 10836 5683 -279 -941 -2181 O

ATOM 117 OD2 ASP A 31 29.276 21. .956 -26. .216 1. .00 63. .54 O

ANISOU 117 OD2 ASP A 31 6709 11885 5547 -106 -866 -2005 O

ATOM 118 N GLY A 32 29.020 22. .357 -21. .089 1. .00 52. .24 N

ANISOU 118 N GLY A 32 5499 8828 5520 -252 -765 -1637 N

ATOM 119 CA GLY A 32 28.357 21. .561 -20. .041 1. .00 50. .71 C

ANISOU 119 CA GLY A 32 5175 8451 5640 -329 -825 -1786 C

ATOM 120 C GLY A 32 28.067 20. .083 -20. .308 1. .00 51. .65 C

ANISOU 120 C GLY A 32 5085 8665 5874 -508 -868 -2188 C

ATOM 121 O GLY A 32 27.626 19. .358 -19. .415 1. .00 50. .73 O

ANISOU 121 O GLY A 32 4900 8331 6043 -602 -858 -2300 O

ATOM 122 N SER A 33 28.298 19. .627 -21. .537 1. .00 53. .93 N

ANISOU 122 N SER A 33 5291 9263 5937 -566 -889 -2415 N

ATOM 123 CA SER A 33 27.990 18. .238 -21. .896 1. .00 55. .61 C

ANISOU 123 CA SER A 33 5323 9557 6249 -763 -903 -2853 C

ATOM 124 C SER A 33 29.075 17. .279 -21. .455 1. .00 54. .38 C

ANISOU 124 C SER A 33 5263 9010 6389 -882 -747 -3028 C

ATOM 125 O SER A 33 30.215 17. .682 -21. .261 1. .00 52. .85 O

ANISOU 125 O SER A 33 5214 8651 6214 -813 -656 -2864 O

ATOM 126 CB SER A 33 27.813 18. .100 -23. .396 1. .00 59. .05 C

ANISOU 126 CB SER A 33 5626 10512 6297 -771 -985 -3076 C

ATOM 127 OG SER A 33 29.010 18. .453 -24. .055 1. .00 59. .06 0

ANISOU 127 OG SER A 33 5777 10545 6119 -715 -889 -2992 0

ATOM 128 N ARG A 34 28.759 15. .990 -21. .391 1. .00 55. .72 N

ANISOU 128 N ARG A 34 5344 9057 6770 -1058 -696 -3382 N

ATOM 129 CA ARG A 34 29.718 15. .048 -20. .844 1. .00 54. .98 C

ANISOU 129 CA ARG A 34 5372 8540 6977 -1096 -524 -3500 C

ATOM 130 C ARG A 34 31.007 15. .223 -21. .630 1. .00 55. .25 C

ANISOU 130 C ARG A 34 5471 8694 6828 -1020 -466 -3524 C

ATOM 131 O ARG A 34 32.100 15. .129 -21. .082 1. .00 53. .84 O

ANISOU 131 O ARG A 34 5397 8263 6799 -933 -358 -3427 O

ATOM 132 CB ARG A 34 29.208 13. .626 -20. .974 1. .00 57. .56 C

ANISOU 132 CB ARG A 34 5635 8722 7514 -1306 -431 -3919 c

ATOM 133 CG ARG A 34 30.294 12. .572 -20. .822 1. .00 58. .10 c

ANISOU 133 CG ARG A 34 5850 8413 7813 -1289 -228 -4091 c

ATOM 134 CD ARG A 34 30.153 11. .807 -19. .519 1. .00 57. .52 c

ANISOU 134 CD ARG A 34 5904 7812 8139 -1290 -74 -4018 c

ATOM 135 NE ARG A 34 29.000 10. .900 -19. .553 1. .00 60. .28 N

ANISOU 135 NE ARG A 34 6186 8055 8664 -1559 2 -4325 N

ATOM 136 CZ ARG A 34 29.076 9. .577 -19. .533 1. .00 63. .09 C

ANISOU 136 CZ ARG A 34 6653 8029 9288 -1690 233 -4632 C

ATOM 137 NH1 ARG A 34 30.255 8. .986 -19. .463 1. .00 63. .41 N

ANISOU 137 NH1 ARG A 34 6880 7768 9443 -1508 395 -4645 N

ATOM 138 NH2 ARG A 34 27.971 8. .848 -19. .572 1. .00 66. .01 N

ANISOU 138 NH2 ARG A 34 6945 8316 9818 -2001 323 -4932 N

ATOM 139 N LYS A 35 30.849 15. .496 -22. .922 1. .00 57. .47 N

ANISOU 139 N LYS A 35 5664 9416 6756 -1041 -538 -3652 N

ATOM 140 CA LYS A 35 31.975 15. .652 -23. .826 1. .00 58. .40 C

ANISOU 140 CA LYS A 35 5823 9718 6650 -990 -463 -3698 C

ATOM 141 C LYS A 35 32.728 16. .973 -23. .664 1. .00 56. .57 C

ANISOU 141 C LYS A 35 5702 9512 6278 -862 -439 -3288 C

ATOM 142 O LYS A 35 33.934 17. .024 -23. .903 1. .00 56. .61 O

ANISOU 142 O LYS A 35 5751 9508 6250 -840 -315 -3288 O

ATOM 143 CB LYS A 35 31.504 15. .505 -25. .271 1. .00 61. .92 C

ANISOU 143 CB LYS A 35 6142 10668 6716 -1048 -539 -3969 C

ATOM 144 N ASN A 36 32.009 18. .026 -23. .273 1. .00 55. .43 N

ANISOU 144 N ASN A 36 5600 9403 6060 -788 -534 -2964 N

ATOM 145 CA ASN A 36 32.560 19. ,380 -23. .139 1. .00 54. .37 C

ANISOU 145 CA ASN A 36 5610 9249 5798 -697 -479 -2582 C

ATOM 146 C ASN A 36 32.167 20. .069 -21. .827 1. .00 51. .83 C

ANISOU 146 C ASN A 36 5378 8620 5697 -644 -506 -2299 C ATOM 147 O ASN A 36 31.466 21..074 -21..851 1..00 52..08 O

ANISOU 147 O ASN A 36 5480 8732 5576 -538 -559 - 2037 O

ATOM 148 CB ASN A 36 32.128 20. .238 -24. .333 1. .00 56. .88 C

ANISOU 148 CB ASN A 36 5956 9983 5673 -600 -522 - 2430 C

ATOM 149 CG ASN A 36 33.273 20. .524 -25. .282 1. .00 58. .50 C

ANISOU 149 CG ASN A 36 6229 10364 5634 -621 -369 - 2416 C

ATOM 150 OD1 ASN A 36 34.163 19. .685 -25. .499 1. .00 58. .79 O

ANISOU 150 OD1 ASN A 36 6198 10383 5756 -715 -278 - 2689 O

ATOM 151 ND2 ASN A 36 33.273 21. .729 -25. .836 1. .00 59. .92 N

ANISOU 151 ND2 ASN A 36 6559 10697 5511 -517 -307 - 2082 N

ATOM 152 N PRO A 37 32.609 19. .525 -20. .682 1. .00 49. .80 N

ANISOU 152 N PRO A 37 5123 8023 5774 -681 -462 - 2349 N

ATOM 153 CA PRO A 37 32.202 20. .081 -19. .381 1. .00 47. .65 C

ANISOU 153 CA PRO A 37 4924 7486 5694 -631 -489 - 2122 C

ATOM 154 C PRO A 37 32.894 21. .388 -19. .027 1. .00 46. .86 C

ANISOU 154 C PRO A 37 4972 7294 5537 -611 -407 - 1852 C

ATOM 155 O PRO A 37 34.004 21. .646 -19. .507 1. .00 47. .56 O

ANISOU 155 O PRO A 37 5087 7450 5534 -675 -296 - 1868 O

ATOM 156 CB PRO A 37 32.650 19. .007 -18. .382 1. .00 46. .45 C

ANISOU 156 CB PRO A 37 4738 7054 5860 -652 -444 - 2268 C

ATOM 157 CG PRO A 37 33.743 18. .294 -19. .066 1. .00 47. .66 C

ANISOU 157 CG PRO A 37 4843 7281 5984 -682 -355 - 2486 C

ATOM 158 CD PRO A 37 33.455 18. .329 -20. .532 1. .00 49. .87 C

ANISOU 158 CD PRO A 37 5076 7896 5977 -729 -379 - 2614 C

ATOM 159 N ALA A 38 32.292 22. .137 -18. .097 1. .00 45. .64 N

ANISOU 159 N ALA A 38 4907 6965 5469 -549 -435 - 1642 N

ATOM 160 CA ALA A 38 32.889 23. .389 -17. .591 1. .00 45. .22 C

ANISOU 160 CA ALA A 38 5020 6753 5409 -567 -330 - 1429 C

ATOM 161 C ALA A 38 33.205 23. .337 -16. .082 1. .00 43. .31 C

ANISOU 161 C ALA A 38 4780 6258 5418 -586 -326 - 1433 C

ATOM 162 O ALA A 38 32.675 22. ,479 -15. .385 1. .00 42. .27 O

ANISOU 162 O ALA A 38 4563 6050 5448 -532 -406 - 1510 O

ATOM 163 CB ALA A 38 31.977 24. .558 -17. .916 1. .00 46. .34 C

ANISOU 163 CB ALA A 38 5317 6916 5373 -442 -328 - 1164 C

ATOM 164 N ARG A 39 34.012 24. .275 -15. .583 1. .00 43. .32 N

ANISOU 164 N ARG A 39 4883 6143 5433 -670 -220 - 1355 N

ATOM 165 CA ARG A 39 34.537 24. .225 -14. .206 1. .00 42. .11 C

ANISOU 165 CA ARG A 39 4695 5847 5458 -697 -223 - 1409 C

ATOM 166 C ARG A 39 33.514 24. .222 -13. .043 1. .00 40. .78 C

ANISOU 166 C ARG A 39 4567 5516 5413 -575 -305 - 1321 C

ATOM 167 O ARG A 39 33.611 23. .417 -12. .123 1. .00 39. .85 O

ANISOU 167 O ARG A 39 4356 5357 5427 -519 -358 - 1396 O

ATOM 168 CB ARG A 39 35.555 25. .347 -13. .984 1. .00 43. .12 C

ANISOU 168 CB ARG A 39 4905 5926 5553 -869 -80 - 1397 C

ATOM 169 N ASN A 40 32.570 25. .160 -13. .064 1. .00 41. .10 N

ANISOU 169 N ASN A 40 4756 5468 5392 -508 -292 - 1144 N

ATOM 170 CA ASN A 40 31.462 25. .167 -12. .133 1. .00 40. .23 C

ANISOU 170 CA ASN A 40 4664 5251 5371 -375 -356 - 1060 C

ATOM 171 C ASN A 40 30.190 25. .512 -12. .902 1. .00 41. .20 C

ANISOU 171 C ASN A 40 4818 5460 5375 -236 -397 -920 C

ATOM 172 O ASN A 40 30.247 26. .142 -13. .970 1. .00 42. .73 O

ANISOU 172 O ASN A 40 5103 5739 5393 -217 -349 -825 O

ATOM 173 CB ASN A 40 31.714 26. ,205 -11. .042 1. .00 40. .19 C

ANISOU 173 CB ASN A 40 4805 5056 5409 -397 -279 - 1005 C

ATOM 174 N CYS A 41 29.029 25. .121 -12. .382 1. .00 40. .78 N

ANISOU 174 N CYS A 41 4678 5423 5392 -120 -476 -895 N

ATOM 175 CA CYS A 41 27.781 25. .666 -12. .918 1. .00 42. .18 C

ANISOU 175 CA CYS A 41 4856 5732 5438 57 -519 -751 C

ATOM 176 C CYS A 41 27.906 27. .194 -13. .052 1. .00 43. .48 C

ANISOU 176 C CYS A 41 5287 5751 5483 165 -401 -535 C

ATOM 177 O CYS A 41 27.522 27. .778 -14. .056 1. .00 45. .46 O ANISOU 177 O CYS A 41 5609 6130 5534 306 -389 -386 O

ATOM 178 CB CYS A 41 26.572 25. .249 -12. .074 1. .00 41. , 82 C

ANISOU 178 CB CYS A 41 4676 5709 5506 151 -579 -752 C

ATOM 179 SG CYS A 41 26.119 23. .512 -12. .210 1. .00 41. , 67 S

ANISOU 179 SG CYS A 41 4377 5842 5615 10 -658 -991 S

ATOM 180 N ARG A 42 28.530 27. .834 -12. .081 1. .00 42. ,86 N

ANISOU 180 N ARG A 42 5372 5402 5512 92 -293 -527 N

ATOM 181 CA ARG A 42 28.563 29. .282 -12. .120 1. .00 44. , 64 C

ANISOU 181 CA ARG A 42 5889 5408 5663 171 -132 -346 C

ATOM 182 C ARG A 42 29.233 29. .821 -13. .379 1. .00 46. , 54 C

ANISOU 182 C ARG A 42 6278 5667 5738 112 -17 -250 C

ATOM 183 O ARG A 42 28.754 30. .767 -13. .972 1. .00 48. ,89 O

ANISOU 183 O ARG A 42 6787 5900 5890 303 85 -16 O

ATOM 184 CB ARG A 42 29.280 29. .825 -10. .882 1. .00 44. , 10 C

ANISOU 184 CB ARG A 42 5954 5065 5739 22 -21 -442 C

ATOM 185 N ASP A 43 30.332 29. .226 -13. .779 1. .00 45. , 91 N

ANISOU 185 N ASP A 43 6097 5679 5666 -123 -12 -412 N

ATOM 186 CA ASP A 43 30.962 29. .662 -15. .031 1. .00 47. , 97 C

ANISOU 186 CA ASP A 43 6480 5999 5747 -189 117 -321 C

ATOM 187 C ASP A 43 30.058 29. ,362 -16. .213 1. .00 49. , 28 C

ANISOU 187 C ASP A 43 6569 6474 5680 44 5 -195 C

ATOM 188 O ASP A 43 29.813 30. .234 -17. .053 1. .00 51. , 99 O

ANISOU 188 O ASP A 43 7123 6819 5810 206 119 55 O

ATOM 189 CB ASP A 43 32.335 29. .017 -15. .248 1. .00 47. , 30 C

ANISOU 189 CB ASP A 43 6253 6012 5705 -475 147 -546 C

ATOM 190 CG ASP A 43 33.335 29. .423 -14. .215 1. .00 46. , 93 c

ANISOU 190 CG ASP A 43 6244 5760 5827 -711 259 -689 c

ATOM 191 OD1 ASP A 43 32.924 29. .819 -13. .091 1. .00 46. , 30 0

ANISOU 191 OD1 ASP A 43 6235 5489 5866 -664 251 -688 0

ATOM 192 OD2 ASP A 43 34.536 29. .354 -14. .541 1. .00 47. , 63 0

ANISOU 192 OD2 ASP A 43 6269 5922 5907 -944 359 -823 0

ATOM 193 N LEU A 44 29.534 28. .129 -16. .250 1. .00 47. , 84 N

ANISOU 193 N LEU A 44 6090 6557 5529 67 -205 -372 N

ATOM 194 CA LEU A 44 28.662 27. .748 -17. .360 1. .00 49. ,49 C

ANISOU 194 CA LEU A 44 6160 7142 5503 246 -337 -337 C

ATOM 195 C LEU A 44 27.661 28. .903 -17. .455 1. .00 51. , 75 C

ANISOU 195 C LEU A 44 6625 7403 5633 572 -298 -23 C

ATOM 196 O LEU A 44 27.451 29. .441 -18. .529 1. .00 54. , 57 O

ANISOU 196 O LEU A 44 7087 7947 5702 763 -261 176 0

ATOM 197 CB LEU A 44 27.996 26. .360 -17. .199 1. .00 48. , 24 c

ANISOU 197 CB LEU A 44 5669 7215 5443 202 -537 -597 c

ATOM 198 N LYS A 45 27.146 29. .338 -16. .297 1. .00 50. , 83 N

ANISOU 198 N LYS A 45 6575 7040 5697 657 -277 35 N

ATOM 199 CA LYS A 45 26.221 30. .463 -16. .219 1. .00 53. , 14 C

ANISOU 199 CA LYS A 45 7058 7252 5881 1005 -211 326 C

ATOM 200 C LYS A 45 26.897 31. .702 -16. .742 1. .00 55. , 65 C

ANISOU 200 C LYS A 45 7779 7289 6076 1050 49 583 C

ATOM 201 O LYS A 45 26.316 32. .482 -17. .500 1. .00 58. , 98 O

ANISOU 201 O LYS A 45 8373 7789 6248 1389 114 882 O

ATOM 202 CB LYS A 45 25.754 30. .698 -14. .769 1. .00 51. , 66 c

ANISOU 202 CB LYS A 45 6893 6800 5935 1040 -192 296 c

ATOM 203 N PHE A 46 28.145 31. .888 -16. .351 1. .00 54. , 57 N

ANISOU 203 N PHE A 46 7793 6837 6104 711 217 469 N

ATOM 204 CA PHE A 46 28.857 33. .072 -16. .774 1. .00 57. , 36 C

ANISOU 204 CA PHE A 46 8541 6867 6386 665 523 678 C

ATOM 205 C PHE A 46 29.131 33. .128 -18. .270 1. .00 59. , 95 C

ANISOU 205 C PHE A 46 8934 7438 6406 734 585 849 C

ATOM 206 O PHE A 46 28.996 34. .173 -18. .905 1. .00 63. , 65 O

ANISOU 206 O PHE A 46 9746 7751 6686 950 804 1185 O

ATOM 207 CB PHE A 46 30.179 33. .178 -16. .012 1. .00 56. , 00 c

ANISOU 207 CB PHE A 46 8432 6389 6456 224 680 445 c ATOM 208 N CYS A 47 29.516 31..993 -18..833 1..00 58..39 N

ANISOU 208 N CYS A 47 8427 7614 6146 569 413 624 N

ATOM 209 CA CYS A 47 29.879 31. .958 -20. .241 1. .00 60. .88 C

ANISOU 209 CA CYS A 47 8778 8205 6148 602 473 737 C

ATOM 210 C CYS A 47 28.749 31. .557 -21. .148 1. .00 62. .58 C

ANISOU 210 C CYS A 47 8809 8928 6040 965 246 832 C

ATOM 211 O CYS A 47 28.888 31. .575 -22. .375 1. .00 65. .27 O

ANISOU 211 O CYS A 47 9181 9572 6045 1066 277 951 O

ATOM 212 CB CYS A 47 31.081 31. .043 -20. .452 1. .00 59. .05 C

ANISOU 212 CB CYS A 47 8339 8099 5998 217 464 420 C

ATOM 213 SG CYS A 47 32.530 31. .673 -19. .528 1. .00 58. .34 S

ANISOU 213 SG CYS A 47 8430 7522 6216 -214 753 304 S

ATOM 214 N HIS A 48 27.675 31. .088 -20. .536 1. .00 61. .15 N

ANISOU 214 N HIS A 48 8386 8897 5950 1124 11 731 N

ATOM 215 CA HIS A 48 26.444 30. .700 -21. .216 1. .00 63. .05 C

ANISOU 215 CA HIS A 48 8371 9676 5910 1455 -232 760 C

ATOM 216 C HIS A 48 25.313 31. .232 -20. .396 1. .00 63. .41 C

ANISOU 216 C HIS A 48 8424 9628 6041 1758 -283 908 C

ATOM 217 O HIS A 48 24.650 30. .487 -19. .659 1. .00 61. .29 O

ANISOU 217 O HIS A 48 7849 9476 5961 1699 -469 674 O

ATOM 218 CB HIS A 48 26.337 29. .186 -21. .330 1. .00 60. .95 C

ANISOU 218 CB HIS A 48 7669 9781 5709 1220 -483 333 C

ATOM 219 CG HIS A 48 27.438 28. .557 -22. .151 1. .00 60. .79 c

ANISOU 219 CG HIS A 48 7614 9880 5603 946 -435 144 c

ATOM 220 ND1 HIS A 48 28.531 29. .242 -22. .556 1. .00 61. .78 N

ANISOU 220 ND1 HIS A 48 8037 9778 5659 846 -184 314 N

ATOM 221 CD2 HIS A 48 27.599 27. .243 -22. .616 1. .00 60. .03 C

ANISOU 221 CD2 HIS A 48 7207 10105 5496 738 -589 -236 C

ATOM 222 CE1 HIS A 48 29.339 28. .424 -23. .239 1. .00 61. .53 C

ANISOU 222 CE1 HIS A 48 7867 9954 5559 615 -192 67 C

ATOM 223 NE2 HIS A 48 28.773 27. .191 -23. .276 1. .00 60. .45 N

ANISOU 223 NE2 HIS A 48 7371 10136 5461 561 -441 -274 N

ATOM 224 N PRO A 49 25.085 32. .548 -20. .494 1. .00 66. .49 N

ANISOU 224 N PRO A 49 9187 9774 6301 2094 -80 1308 N

ATOM 225 CA PRO A 49 24.097 33. .202 -19. .656 1. .00 67. .22 C

ANISOU 225 CA PRO A 49 9344 9705 6489 2418 -73 1468 C

ATOM 226 C PRO A 49 22.718 32. .617 -19. .864 1. .00 68. .34 C

ANISOU 226 C PRO A 49 9052 10460 6455 2722 -378 1396 C

ATOM 227 O PRO A 49 21.967 32. .455 -18. .908 1. .00 67. .02 O

ANISOU 227 O PRO A 49 8705 10272 6487 2775 -466 1291 O

ATOM 228 CB PRO A 49 24.142 34. .649 -20. .134 1. .00 71. .62 C

ANISOU 228 CB PRO A 49 10406 9960 6846 2782 222 1939 C

ATOM 229 CG PRO A 49 25.520 34. .825 -20. .638 1. .00 71. .63 C

ANISOU 229 CG PRO A 49 10676 9686 6853 2424 460 1949 C

ATOM 230 CD PRO A 49 25.899 33. ,517 -21. .244 1. .00 69. .45 C

ANISOU 230 CD PRO A 49 9998 9893 6497 2134 222 1619 C

ATOM 231 N GLU A 50 22.406 32. .288 -21. .105 1. .00 71. .10 N

ANISOU 231 N GLU A 50 9210 11387 6418 2898 -531 1426 N

ATOM 232 CA GLU A 50 21.093 31. .776 -21. .460 1. .00 73. .23 C

ANISOU 232 CA GLU A 50 9021 12349 6456 3181 -827 1328 C

ATOM 233 C GLU A 50 20.756 30. .405 -20. .861 1. .00 69. .95 C

ANISOU 233 C GLU A 50 8123 12146 6308 2787 -1047 835 C

ATOM 234 O GLU A 50 19.639 30. .191 -20. .391 1. .00 70. .64 O

ANISOU 234 O GLU A 50 7892 12514 6433 2938 -1194 745 O

ATOM 235 CB GLU A 50 20.975 31. .689 -22. .973 1. .00 77. .29 C

ANISOU 235 CB GLU A 50 9430 13479 6456 3411 -942 1419 C

ATOM 236 CG GLU A 50 21.832 30. .596 -23. .584 1. .00 75. .37 c

ANISOU 236 CG GLU A 50 9021 13408 6209 2936 -1016 1052 c

ATOM 237 CD GLU A 50 23.299 30. .982 -23. .692 1. .00 73. .84 c

ANISOU 237 CD GLU A 50 9263 12664 6128 2664 -726 1171 c

ATOM 238 OE1 GLU A 50 23.681 32. .078 -23. .213 1. .00 74. .08 0 ANISOU 238 OE1 GLU A 50 9732 12132 6283 2771 -453 1502 O

ATOM 239 OE2 GLU A 50 24.072 30. .193 -24. .274 1. .00 72. .82 O

ANISOU 239 OE2 GLU A 50 9030 12678 5960 2334 -752 911 O

ATOM 240 N LEU A 51 21.699 29. .469 -20. .885 1. .00 66. .87 N

ANISOU 240 N LEU A 51 7680 11625 6102 2297 -1046 520 N

ATOM 241 CA LEU A 51 21.342 28. .088 -20. .539 1. .00 64. .87 C

ANISOU 241 CA LEU A 51 6995 11600 6054 1953 -1228 65 C

ATOM 242 C LEU A 51 20.483 28. .010 -19. .279 1. .00 63. .50 C

ANISOU 242 C LEU A 51 6665 11295 6168 1972 -1252 12 C

ATOM 243 O LEU A 51 20.775 28. .658 -18. .277 1. .00 61. .56 O

ANISOU 243 O LEU A 51 6699 10533 6157 1998 -1088 183 O

ATOM 244 CB LEU A 51 22.579 27. .198 -20. .409 1. .00 61. .48 C

ANISOU 244 CB LEU A 51 6624 10860 5874 1467 -1154 -214 C

ATOM 245 N LYS A 52 19.417 27. .223 -19. .360 1. .00 64. .98 N

ANISOU 245 N LYS A 52 6391 11982 6317 1943 -1444 -249 N

ATOM 246 CA LYS A 52 18.464 27. .050 -18. .253 1. .00 64. .39 C

ANISOU 246 CA LYS A 52 6094 11890 6481 1950 -1463 -325 C

ATOM 247 C LYS A 52 18.853 25. ,996 -17. .212 1. .00 60. .61 C

ANISOU 247 C LYS A 52 5564 11026 6437 1473 -1389 -615 C

ATOM 248 O LYS A 52 19.607 25. .067 -17. .488 1. .00 59. .09 O

ANISOU 248 O LYS A 52 5364 10736 6352 1115 -1383 -866 O

ATOM 249 CB LYS A 52 17.069 26. .730 -18. .798 1. .00 68. .52 C

ANISOU 249 CB LYS A 52 6100 13178 6756 2127 -1679 -481 C

ATOM 250 N SER A 53 18.330 26. .137 -16. .005 1. .00 59. .46 N

ANISOU 250 N SER A 53 5399 10666 6528 1503 -1316 -566 N

ATOM 251 CA SER A 53 18.718 25. .198 -14. .985 1. .00 56. .34 C

ANISOU 251 CA SER A 53 5002 9899 6505 1111 -1221 -775 C

ATOM 252 C SER A 53 18.367 23. .840 -15. .532 1. .00 57. .58 C

ANISOU 252 C SER A 53 4792 10389 6696 Ill -1316 - 1166 C

ATOM 253 O SER A 53 17.259 23. .640 -16. .032 1. .00 60. .90 O

ANISOU 253 O SER A 53 4826 11358 6955 840 -1446 - 1308 O

ATOM 254 CB SER A 53 17.979 25. .458 -13. .680 1. .00 55. .82 C

ANISOU 254 CB SER A 53 4894 9685 6631 1206 -1137 -691 C

ATOM 255 OG SER A 53 18.327 26. .728 -13. .147 1. .00 55. .03 0

ANISOU 255 OG SER A 53 5161 9237 6511 1496 -1025 -376 0

ATOM 256 N GLY A 54 19.323 22. .926 -15. .470 1. .00 55. .42 N

ANISOU 256 N GLY A 54 4634 9803 6620 431 -1243 - 1356 N

ATOM 257 CA GLY A 54 19.113 21. .539 -15. .895 1. .00 56. .72 C

ANISOU 257 CA GLY A 54 4525 10144 6882 64 -1268 - 1763 C

ATOM 258 C GLY A 54 20.320 20. ,684 -15. .554 1. .00 54. .05 C

ANISOU 258 C GLY A 54 4425 9309 6805 -219 -1131 - 1879 C

ATOM 259 O GLY A 54 21.345 21. .220 -15. .138 1. .00 51. .40 O

ANISOU 259 O GLY A 54 4411 8602 6516 -124 -1056 - 1658 O

ATOM 260 N GLU A 55 20.207 19. .364 -15. .699 1. .00 55. .19 N

ANISOU 260 N GLU A 55 4408 9440 7121 -561 -1079 - 2233 N

ATOM 261 CA GLU A 55 21.383 18. .512 -15. .524 1. .00 53. .38 C

ANISOU 261 CA GLU A 55 4409 8767 7106 -761 -943 - 2341 C

ATOM 262 C GLU A 55 22.464 18. .933 -16. .526 1. .00 52. .80 C

ANISOU 262 C GLU A 55 4501 8758 6804 -656 -1007 - 2298 C

ATOM 263 O GLU A 55 22.212 19. .044 -17. .722 1. .00 55. .16 O

ANISOU 263 O GLU A 55 4647 9491 6820 -629 -1132 - 2429 O

ATOM 264 CB GLU A 55 21.023 17. .036 -15. .707 1. .00 55. .69 C

ANISOU 264 CB GLU A 55 4528 9029 7604 -1132 -847 - 2753 C

ATOM 265 N TYR A 56 23.654 19. .211 -16. .001 1. .00 50. .01 N

ANISOU 265 N TYR A 56 4440 8014 6547 -589 -915 - 2109 N

ATOM 266 CA TYR A 56 24.823 19. .598 -16. .804 1. .00 49. .44 C

ANISOU 266 CA TYR A 56 4534 7953 6299 -526 -923 - 2060 C

ATOM 267 C TYR A 56 26.099 18. .925 -16. .296 1. .00 47. .59 C

ANISOU 267 C TYR A 56 4476 7319 6287 -627 -788 - 2116 C

ATOM 268 O TYR A 56 26.129 18. .467 -15. .174 1. .00 46. .37 O

ANISOU 268 O TYR A 56 4379 6853 6388 -663 -698 - 2081 O ATOM 269 CB TYR A 56 24.990 21..131 -16..834 1..00 48..75 C

ANISOU 269 CB TYR A 56 4612 7909 6001 -263 -955 -1704 C

ATOM 270 CG TYR A 56 23.862 21. .867 -17. .519 1. .00 51. .25 C

ANISOU 270 CG TYR A 56 4782 8660 6031 -60 -1084 -1604 C

ATOM 271 CD1 TYR A 56 23.265 21. .361 -18. .654 1. .00 54. .23 C

ANISOU 271 CD1 TYR A 56 4906 9511 6188 -106 -1205 -1841 C

ATOM 272 CD2 TYR A 56 23.419 23. ,084 -17. .041 1. .00 51. .12 C

ANISOU 272 CD2 TYR A 56 4880 8603 5940 206 -1081 -1281 C

ATOM 273 CE1 TYR A 56 22.233 22. .031 -19. .277 1. .00 57. .08 C

ANISOU 273 CE1 TYR A 56 5095 10353 6239 136 -1345 -1740 C

ATOM 274 CE2 TYR A 56 22.391 23. .773 -17. .657 1. .00 53. .92 C

ANISOU 274 CE2 TYR A 56 5104 9372 6012 474 -1192 -1154 C

ATOM 275 CZ TYR A 56 21.805 23. .249 -18. .777 1. .00 56. .93 C

ANISOU 275 CZ TYR A 56 5200 10279 6150 456 -1336 -1371 C

ATOM 276 OH TYR A 56 20.787 23. .947 -19. .387 1. .00 60. .23 O

ANISOU 276 OH TYR A 56 5457 11188 6241 780 -1467 -1231 O

ATOM 277 N TRP A 57 27.132 18. .851 -17. .127 1. .00 47. .79 N

ANISOU 277 N TRP A 57 4573 7393 6193 -645 -770 -2195 N

ATOM 278 CA TRP A 57 28.371 18. .188 -16. .729 1. .00 46. .62 C

ANISOU 278 CA TRP A 57 4545 6942 6227 -694 -649 -2264 C

ATOM 279 C TRP A 57 29.441 19. .189 -16. .475 1. .00 44. .97 C

ANISOU 279 C TRP A 57 4493 6654 5941 -585 -620 -2033 C

ATOM 280 O TRP A 57 29.874 19. .900 -17. .394 1. .00 45. .67 O

ANISOU 280 O TRP A 57 4617 6944 5792 -557 -633 -1978 O

ATOM 281 CB TRP A 57 28.856 17. .262 -17. .824 1. .00 48. .52 C

ANISOU 281 CB TRP A 57 4726 7299 6411 -809 -616 -2577 C

ATOM 282 CG TRP A 57 28.086 15. .970 -17. .918 1. .00 50. .57 c

ANISOU 282 CG TRP A 57 4866 7506 6842 -990 -572 -2899 c

ATOM 283 CD1 TRP A 57 26.905 15. .728 -18. .615 1. .00 53. .08 c

ANISOU 283 CD1 TRP A 57 4978 8142 7049 -1125 -658 -3122 c

ATOM 284 CD2 TRP A 57 28.421 14. .692 -17. .287 1. .00 51. .00 c

ANISOU 284 CD2 TRP A 57 5002 7160 7217 -1074 -401 -3058 c

ATOM 285 NE1 TRP A 57 26.506 14. .432 -18. .454 1. .00 54. .98 N

ANISOU 285 NE1 TRP A 57 5167 8184 7541 -1345 -538 -3435 N

ATOM 286 CE2 TRP A 57 27.360 13. .761 -17. .670 1. .00 53. .89 C

ANISOU 286 CE2 TRP A 57 5227 7574 7675 -1313 -364 -3390 C

ATOM 287 CE3 TRP A 57 29.449 14. .247 -16. .473 1. .00 49. .86 C

ANISOU 287 CE3 TRP A 57 5023 6652 7268 -960 -269 -2960 C

ATOM 288 CZ2 TRP A 57 27.347 12. .450 -17. .245 1. .00 55. .56 C

ANISOU 288 CZ2 TRP A 57 5521 7390 8198 -1455 -157 -3596 c

ATOM 289 CZ3 TRP A 57 29.438 12. .914 -16. .065 1. .00 51. .53 c

ANISOU 289 CZ3 TRP A 57 5316 6503 7761 -1029 -84 -3131 c

ATOM 290 CH2 TRP A 57 28.406 12. .037 -16. .443 1. .00 54. .34 c

ANISOU 290 CH2 TRP A 57 5589 6821 8235 -1283 -8 -3435 c

ATOM 291 N VAL A 58 29.899 19. .242 -15. .232 1. .00 43. .23 N

ANISOU 291 N VAL A 58 4362 6156 5906 -538 -562 -1909 N

ATOM 292 CA VAL A 58 30.963 20. .162 -14. .830 1. .00 42. .05 C

ANISOU 292 CA VAL A 58 4330 5939 5708 -486 -523 -1749 C

ATOM 293 C VAL A 58 32.164 19. .342 -14. .337 1. .00 41. .73 C

ANISOU 293 C VAL A 58 4282 5763 5809 -480 -449 -1858 C

ATOM 294 O VAL A 58 31.973 18. .263 -13. .778 1. .00 41. .89 O

ANISOU 294 O VAL A 58 4283 5621 6013 -452 -414 -1938 0

ATOM 295 CB VAL A 58 30.495 21. .150 -13. .734 1. .00 40. .84 c

ANISOU 295 CB VAL A 58 4269 5657 5590 -407 -535 -1522 c

ATOM 296 CGI VAL A 58 29.410 22. .053 -14. .262 1. .00 41. .65 c

ANISOU 296 CGI VAL A 58 4389 5905 5532 -339 -591 -1386 c

ATOM 297 CG2 VAL A 58 30.001 20. .402 -12. .503 1. .00 40. .09 c

ANISOU 297 CG2 VAL A 58 4151 5374 5708 -371 -522 -1520 c

ATOM 298 N ASP A 59 33.385 19. .849 -14. .557 1. .00 41. .77 N

ANISOU 298 N ASP A 59 4299 5845 5724 -495 -406 -1854 N

ATOM 299 CA ASP A 59 34.626 19. .185 -14. .172 1. .00 42. .00 C ANISOU 299 CA ASP A 59 4272 5849 5839 -444 -348 -1959 C

ATOM 300 C ASP A 59 35.512 20. .118 -13. .343 1. .00 41. .44 C

ANISOU 300 C ASP A 59 4204 5802 5738 -447 -335 -1861 C

ATOM 301 O ASP A 59 36.337 20. .832 -13. .896 1. .00 42. .13 O

ANISOU 301 O ASP A 59 4267 6037 5704 -553 -282 -1887 O

ATOM 302 CB ASP A 59 35.351 18. .761 -15. .453 1. .00 43. .53 C

ANISOU 302 CB ASP A 59 4393 6221 5925 -493 -293 -2144 C

ATOM 303 CG ASP A 59 36.736 18. .131 -15. .187 1. .00 44. .33 C

ANISOU 303 CG ASP A 59 4397 6359 6085 -399 -224 -2262 C

ATOM 304 OD1 ASP A 59 36.879 17. .417 -14. .164 1. .00 44. .18 O

ANISOU 304 OD1 ASP A 59 4376 6187 6225 -243 -220 -2243 O

ATOM 305 OD2 ASP A 59 37.675 18. .331 -16. .010 1. .00 45. .48 O

ANISOU 305 OD2 ASP A 59 4463 6714 6103 -454 -161 -2362 O

ATOM 306 N PRO A 60 35.348 20. .101 -12. .011 1. .00 40. .60 N

ANISOU 306 N PRO A 60 4121 5571 5734 -352 -366 -1771 N

ATOM 307 CA PRO A 60 36.008 21. .058 -11. .116 1. .00 40. .41 C

ANISOU 307 CA PRO A 60 4092 5596 5665 -382 -369 -1721 C

ATOM 308 C PRO A 60 37.539 21. .031 -11. .120 1. .00 41. .67 C

ANISOU 308 C PRO A 60 4092 5971 5769 -403 -334 -1861 C

ATOM 309 O PRO A 60 38.153 22. .102 -11. .126 1. .00 42. .26 O

ANISOU 309 O PRO A 60 4149 6149 5760 -575 -291 -1891 O

ATOM 310 CB PRO A 60 35.486 20. .670 -9. .742 1. .00 39. .73 C

ANISOU 310 CB PRO A 60 4040 5380 5676 -227 -412 -1628 C

ATOM 311 CG PRO A 60 34.157 20. .060 -10. .006 1. .00 39. .24 c

ANISOU 311 CG PRO A 60 4050 5155 5705 -197 -416 -1567 c

ATOM 312 CD PRO A 60 34.291 19. .346 -11. .317 1. .00 40. .09 c

ANISOU 312 CD PRO A 60 4106 5318 5808 -251 -387 -1707 c

ATOM 313 N ASN A 61 38.149 19. .850 -11. .118 1. .00 42. .53 N

ANISOU 313 N ASN A 61 4085 6147 5928 -234 -331 -1956 N

ATOM 314 CA ASN A 61 39.592 19. .760 -11. .152 1. .00 44. .18 C

ANISOU 314 CA ASN A 61 4088 6628 6070 -207 -304 -2100 C

ATOM 315 C ASN A 61 40.171 19. .949 -12. .534 1. .00 45. .20 C

ANISOU 315 C ASN A 61 4150 6910 6113 -370 -214 -2224 C

ATOM 316 O ASN A 61 41.381 19. .863 -12. .752 1. .00 46. .91 O

ANISOU 316 O ASN A 61 4163 7392 6268 -371 -166 -2367 O

ATOM 317 CB ASN A 61 40.085 18. .477 -10. .494 1. .00 45. .31 c

ANISOU 317 CB ASN A 61 4137 6801 6278 119 -321 -2122 c

ATOM 318 CG ASN A 61 39.740 17. .244 -11. .276 1. .00 45. .82 c

ANISOU 318 CG ASN A 61 4278 6686 6447 243 -251 -2167 c

ATOM 319 OD1 ASN A 61 39.358 17. .311 -12. .451 1. .00 45. .60 0

ANISOU 319 OD1 ASN A 61 4301 6622 6402 72 -209 -2244 0

ATOM 320 ND2 ASN A 61 39.860 16. .091 -10. .629 1. .00 46. .99 N

ANISOU 320 ND2 ASN A 61 4450 6715 6690 550 -222 -2126 N

ATOM 321 N GLN A 62 39.274 20. .217 -13. .464 1. .00 44. .48 N

ANISOU 321 N GLN A 62 4214 6694 5993 -491 -191 -2165 N

ATOM 322 CA GLN A 62 39.640 20. .511 -14. .826 1. .00 45. .62 C

ANISOU 322 CA GLN A 62 4340 6987 6005 -642 -98 -2239 C

ATOM 323 C GLN A 62 40.562 19. .419 -15. .333 1. .00 47. .21 C

ANISOU 323 C GLN A 62 4371 7357 6211 -514 -47 -2434 C

ATOM 324 O GLN A 62 40.251 18. .230 -15. .196 1. .00 47. .26 O

ANISOU 324 O GLN A 62 4392 7234 6331 -313 -74 -2489 O

ATOM 325 CB GLN A 62 40.328 21. .867 -14. .914 1. .00 46. .50 C

ANISOU 325 CB GLN A 62 4440 7218 6010 -885 -1 -2214 C

ATOM 326 CG GLN A 62 39.420 23. .032 -14. .584 1. .00 45. .54 C

ANISOU 326 CG GLN A 62 4542 6885 5878 -996 -2 -2022 C

ATOM 327 CD GLN A 62 38.315 23. .201 -15. .583 1. .00 45. .29 c

ANISOU 327 CD GLN A 62 4690 6764 5753 -979 -3 -1885 c

ATOM 328 OE1 GLN A 62 37.189 22. .743 -15. .377 1. .00 44. .04 0

ANISOU 328 OE1 GLN A 62 4597 6482 5653 -840 -114 -1817 0

ATOM 329 NE2 GLN A 62 38.627 23. .864 -16. .682 1. .00 46. .92 N

ANISOU 329 NE2 GLN A 62 4964 7070 5793 -1117 132 -1843 N ATOM 330 N GLY A 63 41.706 19..833 -15..876 1..00 48..92 N

ANISOU 330 N GLY A 63 4430 7842 6314 -634 55 -2543 N

ATOM 331 CA GLY A 63 42.678 18. .925 -16. .457 1. .00 50. .90 C

ANISOU 331 CA GLY A 63 4493 8307 6541 -505 129 -2741 C

ATOM 332 C GLY A 63 41.977 17. .993 -17. .415 1. .00 51. .07 C

ANISOU 332 C GLY A 63 4633 8208 6565 -419 143 -2818 C

ATOM 333 O GLY A 63 41.205 18. .444 -18. .257 1. .00 50. .70 O

ANISOU 333 O GLY A 63 4725 8131 6406 -572 149 -2764 O

ATOM 334 N CYS A 64 42.221 16. .693 -17. .259 1. .00 52. .08 N

ANISOU 334 N CYS A 64 4712 8266 6811 -160 157 -2949 N

ATOM 335 CA CYS A 64 41.530 15. .658 -18. .035 1. .00 52. .77 C

ANISOU 335 CA CYS A 64 4921 8184 6943 -95 191 -3087 C

ATOM 336 C CYS A 64 40.045 15. .886 -17. .983 1. .00 50. .97 C

ANISOU 336 C CYS A 64 4884 7731 6752 -224 98 -2971 C

ATOM 337 O CYS A 64 39.508 16. .252 -16. .939 1. .00 49. .22 O

ANISOU 337 O CYS A 64 4729 7344 6627 -213 14 -2785 O

ATOM 338 CB CYS A 64 41.810 14. .273 -17. .473 1. .00 54. .14 C

ANISOU 338 CB CYS A 64 5100 8160 7311 222 242 -3181 C

ATOM 339 SG CYS A 64 40.862 12. .982 -18. .301 1. .00 55. .55 s

ANISOU 339 SG CYS A 64 5468 8038 7600 229 327 -3403 s

ATOM 340 N LYS A 65 39.381 15. .669 -19. .105 1. .00 51. .76 N

ANISOU 340 N LYS A 65 5047 7872 6750 -336 Ill -3100 N

ATOM 341 CA LYS A 65 37.969 16. ,003 -19. .204 1. .00 50. .63 C

ANISOU 341 CA LYS A 65 5018 7634 6583 -462 9 -3010 C

ATOM 342 C LYS A 65 37.078 14. .781 -18. .921 1. .00 51. .15 C

ANISOU 342 C LYS A 65 5157 7415 6862 -417 12 -3150 C

ATOM 343 O LYS A 65 35.869 14. .889 -18. .761 1. .00 50. .44 O

ANISOU 343 O LYS A 65 5120 7238 6806 -511 -67 -3096 O

ATOM 344 CB LYS A 65 37.676 16. .599 -20. .587 1. .00 51. .75 C

ANISOU 344 CB LYS A 65 5160 8070 6433 -608 4 -3055 c

ATOM 345 N LEU A 66 37.698 13. .612 -18. .837 1. .00 52. .85 N

ANISOU 345 N LEU A 66 5374 7476 7229 -268 132 -3332 N

ATOM 346 CA LEU A 66 36.956 12. .354 -18. .879 1. .00 54. .50 C

ANISOU 346 CA LEU A 66 5686 7387 7636 -275 213 -3538 C

ATOM 347 C LEU A 66 36.406 11. .956 -17. .492 1. .00 53. .56 C

ANISOU 347 C LEU A 66 5682 6891 7778 -183 230 -3349 C

ATOM 348 O LEU A 66 35.717 10. .940 -17. .360 1. .00 55. .16 O

ANISOU 348 O LEU A 66 5998 6776 8184 -223 339 -3484 O

ATOM 349 CB LEU A 66 37.822 11. .257 -19. .539 1. .00 57. .51 C

ANISOU 349 CB LEU A 66 6071 7721 8060 -144 384 -3836 c

ATOM 350 N ASP A 67 36.692 12. .769 -16. .471 1. .00 51. .37 N

ANISOU 350 N ASP A 67 5380 6651 7486 -85 144 -3053 N

ATOM 351 CA ASP A 67 36.236 12. .471 -15. .100 1. .00 50. .64 C

ANISOU 351 CA ASP A 67 5395 6258 7589 33 162 -2844 C

ATOM 352 C ASP A 67 35.319 13. .526 -14. .450 1. .00 48. .14 C

ANISOU 352 C ASP A 67 5078 5988 7225 -92 25 -2615 C

ATOM 353 O ASP A 67 35.279 13. .645 -13. .231 1. .00 47. .23 O

ANISOU 353 O ASP A 67 5012 5748 7186 36 14 -2402 O

ATOM 354 CB ASP A 67 37.425 12. .167 -14. .179 1. .00 51. .25 c

ANISOU 354 CB ASP A 67 5459 6304 7711 361 212 -2715 c

ATOM 355 CG ASP A 67 38.240 13. ,418 -13. .813 1. .00 49. .58 c

ANISOU 355 CG ASP A 67 5086 6443 7310 378 77 -2573 c

ATOM 356 OD1 ASP A 67 38.154 14. .452 -14. .520 1. .00 48. .39 0

ANISOU 356 OD1 ASP A 67 4861 6531 6995 150 -3 -2596 0

ATOM 357 OD2 ASP A 67 38.987 13. .373 -12. .810 1. .00 49. .93 0

ANISOU 357 OD2 ASP A 67 5079 6535 7358 621 66 -2443 0

ATOM 358 N ALA A 68 34.581 14. .274 -15. .271 1. .00 47. .45 N

ANISOU 358 N ALA A 68 4938 6100 6990 -306 -72 -2658 N

ATOM 359 CA ALA A 68 33.604 15. .240 -14. .814 1. .00 45. .68 C

ANISOU 359 CA ALA A 68 4719 5920 6716 -394 - 183 -2464 C

ATOM 360 C ALA A 68 32.468 14. .558 -14. .101 1. .00 46. .02 C ANISOU 360 C ALA A 68 4820 5705 6959 -430 -135 -2442 C

ATOM 361 O ALA A 68 32.377 13. .345 -14. .057 1. .00 47. .84 O

ANISOU 361 O ALA A 68 5112 5693 7373 -429 2 -2587 O

ATOM 362 CB ALA A 68 33.008 15. .965 -15. .993 1. .00 45. .90 C

ANISOU 362 CB ALA A 68 4682 6230 6527 -548 -274 -2526 C

ATOM 363 N ILE A 69 31.562 15. .368 -13. .588 1. .00 44. .66 N

ANISOU 363 N ILE A 69 4636 5578 6753 -474 -221 -2269 N

ATOM 364 CA ILE A 69 30.460 14. .881 -12. .771 1. .00 44. .99 C

ANISOU 364 CA ILE A 69 4709 5413 6972 -518 -162 -2214 C

ATOM 365 C ILE A 69 29.164 15. .542 -13. .178 1. .00 44. .95 C

ANISOU 365 C ILE A 69 4590 5619 6869 -656 -267 -2218 C

ATOM 366 O ILE A 69 29.135 16. .711 -13. .563 1. .00 43. .91 O

ANISOU 366 O ILE A 69 4422 5730 6533 -621 -391 -2111 O

ATOM 367 CB ILE A 69 30.722 15. .028 -11. .248 1. .00 43. .82 C

ANISOU 367 CB ILE A 69 4661 5081 6907 -338 -124 -1954 C

ATOM 368 CGI ILE A 69 31.216 16. .429 -10. .891 1. .00 41. .80 c

ANISOU 368 CGI ILE A 69 4392 5019 6472 -256 -251 -1778 c

ATOM 369 CG2 ILE A 69 31.746 14. ,000 -10. .780 1. .00 45. .03 c

ANISOU 369 CG2 ILE A 69 4915 5016 7180 -154 9 -1957 c

ATOM 370 CD1 ILE A 69 31.367 16. .630 -9. .408 1. .00 41. .04 c

ANISOU 370 CD1 ILE A 69 4367 4813 6411 -99 -233 -1571 c

ATOM 371 N LYS A 70 28.115 14. .734 -13. .139 1. .00 46. .66 N

ANISOU 371 N LYS A 70 4750 5744 7235 -810 -191 -2358 N

ATOM 372 CA LYS A 70 26.792 15. .173 -13. .471 1. .00 47. .38 C

ANISOU 372 CA LYS A 70 4669 6087 7245 -932 -283 -2401 C

ATOM 373 C LYS A 70 26.244 15. .864 -12. .215 1. .00 45. .83 C

ANISOU 373 C LYS A 70 4505 5817 7090 -819 -288 -2113 C

ATOM 374 O LYS A 70 26.060 15. .251 -11. .172 1. .00 46. .05 O

ANISOU 374 O LYS A 70 4613 5566 7316 -820 -145 -2035 0

ATOM 375 CB LYS A 70 25.919 13. ,995 -13. .944 1. .00 50. .48 c

ANISOU 375 CB LYS A 70 4943 6452 7786 -1201 -180 -2732 c

ATOM 376 N VAL A 71 26.039 17. .166 -12. .333 1. .00 44. .59 N

ANISOU 376 N VAL A 71 4314 5897 6731 -699 -430 -1945 N

ATOM 377 CA VAL A 71 25.563 18. .008 -11. .257 1. .00 43. .32 C

ANISOU 377 CA VAL A 71 4193 5696 6569 -566 -441 -1695 C

ATOM 378 C VAL A 71 24.215 18. .569 -11. .693 1. .00 44. .60 C

ANISOU 378 C VAL A 71 4160 6172 6615 -571 -534 -1705 C

ATOM 379 O VAL A 71 23.829 18. .376 -12. .824 1. .00 46. .34 O

ANISOU 379 O VAL A 71 4221 6666 6720 -660 -612 -1890 O

ATOM 380 CB VAL A 71 26.528 19. .189 -11. .049 1. .00 41. .40 c

ANISOU 380 CB VAL A 71 4104 5444 6183 -400 -499 -1502 c

ATOM 381 CGI VAL A 71 27.933 18. .692 -10. .809 1. .00 40. .67 c

ANISOU 381 CGI VAL A 71 4127 5174 6153 -382 -439 -1532 c

ATOM 382 CG2 VAL A 71 26.527 20. .117 -12. .253 1. .00 41. .86 c

ANISOU 382 CG2 VAL A 71 4134 5769 6004 -364 -606 -1493 c

ATOM 383 N PHE A 72 23.489 19. .251 -10. .806 1. .00 44. .16 N

ANISOU 383 N PHE A 72 4094 6121 6563 -451 -529 -1519 N

ATOM 384 CA PHE A 72 22.377 20. ,119 -11. .229 1. .00 45. .43 C

ANISOU 384 CA PHE A 72 4085 6622 6552 -336 -637 -1464 C

ATOM 385 C PHE A 72 22.829 21. .563 -11. .084 1. .00 44. .08 C

ANISOU 385 C PHE A 72 4112 6418 6220 -86 -683 -1209 C

ATOM 386 O PHE A 72 23.323 21. .970 -10. .018 1. .00 42. .45 0

ANISOU 386 O PHE A 72 4091 5949 6089 -13 -609 -1066 0

ATOM 387 CB PHE A 72 21.109 19. .893 -10. .392 1. .00 46. .63 c

ANISOU 387 CB PHE A 72 4062 6833 6823 -364 -569 -1457 c

ATOM 388 CG PHE A 72 20.026 20. .925 -10. .620 1. .00 48. .03 c

ANISOU 388 CG PHE A 72 4069 7368 6814 -151 -673 -1353 c

ATOM 389 CD1 PHE A 72 19.099 20. .747 -11. .625 1. .00 50. .87 c

ANISOU 389 CD1 PHE A 72 4108 8180 7039 -194 -786 -1531 c

ATOM 390 CD2 PHE A 72 19.932 22. .071 -9. .823 1. .00 47. .01 c

ANISOU 390 CD2 PHE A 72 4090 7143 6629 116 -654 -1095 c ATOM 391 CE1 PHE A 72 18.093 21..677 -11..852 1..00 52..74 C

ANISOU 391 CE1 PHE A 72 4161 8802 7075 73 -889 - 1419 C

ATOM 392 CE2 PHE A 72 18.934 23. .004 -10. .045 1. .00 48. .80 C

ANISOU 392 CE2 PHE A 72 4178 7678 6686 372 -727 -986 C

ATOM 393 CZ PHE A 72 18.017 22. .812 -11. .071 1. .00 51. .69 C

ANISOU 393 CZ PHE A 72 4210 8527 6903 378 -851 - 1128 C

ATOM 394 N CYS A 73 22.661 22. .336 -12. .151 1. .00 45. .26 N

ANISOU 394 N CYS A 73 4233 6831 6133 44 -786 - 1161 N

ATOM 395 CA CYS A 73 22.936 23. .773 -12. .109 1. .00 44. .91 C

ANISOU 395 CA CYS A 73 4407 6719 5938 284 -780 -907 C

ATOM 396 C CYS A 73 21.705 24. .570 -11. .796 1. .00 46. .41 C

ANISOU 396 C CYS A 73 4516 7070 6048 533 -801 -756 C

ATOM 397 O CYS A 73 20.747 24. .552 -12. .542 1. .00 48. .77 O

ANISOU 397 O CYS A 73 4579 7756 6196 634 -901 -792 O

ATOM 398 CB CYS A 73 23.471 24. ,262 -13. .431 1. .00 45. .94 C

ANISOU 398 CB CYS A 73 4615 7008 5833 340 -831 -870 C

ATOM 399 SG CYS A 73 25.009 23. .450 -13. .893 1. .00 44. .57 S

ANISOU 399 SG CYS A 73 4527 6684 5723 84 -790 - 1049 s

ATOM 400 N ASN A 74 21.723 25. .272 -10. .679 1. .00 45. .42 N

ANISOU 400 N ASN A 74 4566 6686 6006 650 -707 -606 N

ATOM 401 CA ASN A 74 20.687 26. .237 -10. .434 1. .00 47. .13 C

ANISOU 401 CA ASN A 74 4764 7019 6125 953 -700 -437 C

ATOM 402 C ASN A 74 21.156 27. .472 -11. .156 1. .00 48. .13 C

ANISOU 402 C ASN A 74 5162 7068 6059 1168 -674 -236 C

ATOM 403 O ASN A 74 21.739 28. .344 -10. .555 1. .00 47. .48 O

ANISOU 403 O ASN A 74 5380 6641 6017 1223 -549 -120 O

ATOM 404 CB ASN A 74 20.510 26. .484 -8. .938 1. .00 46. .08 C

ANISOU 404 CB ASN A 74 4727 6633 6148 993 -584 -384 c

ATOM 405 CG ASN A 74 19.280 27. .318 -8. .622 1. .00 48. .23 c

ANISOU 405 CG ASN A 74 4924 7062 6340 1321 -562 -246 c

ATOM 406 OD1 ASN A 74 18.880 28. .173 -9. .403 1. .00 50. .37 0

ANISOU 406 OD1 ASN A 74 5228 7488 6421 1604 -598 -102 0

ATOM 407 ND2 ASN A 74 18.676 27. .072 -7. .465 1. .00 48. .05 N

ANISOU 407 ND2 ASN A 74 4806 7009 6443 1317 -485 -273 N

ATOM 408 N MET A 75 20.929 27. .524 -12. .461 1. .00 50. .14 N

ANISOU 408 N MET A 75 5317 7643 6091 1270 -772 -208 N

ATOM 409 CA MET A 75 21.476 28. .588 -13. .310 1. .00 51. .56 C

ANISOU 409 CA MET A 75 5787 7742 6063 1456 -713 10 C

ATOM 410 C MET A 75 21.000 30. .003 -13. .020 1. .00 53. .61 C

ANISOU 410 C MET A 75 6301 7834 6235 1842 -593 300 C

ATOM 411 O MET A 75 21.446 30. .948 -13. .666 1. .00 55. .32 O

ANISOU 411 O MET A 75 6821 7902 6296 2002 -485 516 O

ATOM 412 CB MET A 75 21.258 28. ,250 -14. .768 1. .00 53. .76 C

ANISOU 412 CB MET A 75 5882 8471 6072 1513 -850 -20 C

ATOM 413 CG MET A 75 22.195 27. .171 -15. .255 1. .00 52. .06 C

ANISOU 413 CG MET A 75 5591 8272 5919 1141 -890 -272 C

ATOM 414 SD MET A 75 23.802 27. .850 -15. .576 1. .00 51. .09 S

ANISOU 414 SD MET A 75 5871 7767 5772 1027 -721 -149 s

ATOM 415 CE MET A 75 24.829 26. .400 -15. .733 1. .00 48. .79 c

ANISOU 415 CE MET A 75 5431 7473 5636 615 -760 -491 c

ATOM 416 N GLU A 76 20.086 30. .121 -12. .061 1. .00 53. .83 N

ANISOU 416 N GLU A 76 6218 7871 6364 1992 -583 305 N

ATOM 417 CA GLU A 76 19.680 31. .386 -11. .467 1. .00 55. .54 C

ANISOU 417 CA GLU A 76 6700 7834 6569 2337 -429 528 C

ATOM 418 C GLU A 76 20.715 31. ,921 -10. .476 1. .00 53. .61 C

ANISOU 418 C GLU A 76 6828 7021 6522 2136 -236 498 C

ATOM 419 O GLU A 76 21.058 33. .113 -10. .511 1. .00 55. .35 O

ANISOU 419 O GLU A 76 7436 6892 6702 2296 -49 675 0

ATOM 420 CB GLU A 76 18.347 31. .203 -10. .735 1. .00 56. .54 c

ANISOU 420 CB GLU A 76 6523 8222 6737 2540 -482 494 c

ATOM 421 CG GLU A 76 17.793 32. .471 -10. .116 1. .00 58. .80 c ANISOU 421 CG GLU A 76 7055 8284 7002 2956 -318 705 C

ATOM 422 CD GLU A 76 17.453 33. .491 -11. .172 1. .00 62. ,76 C

ANISOU 422 CD GLU A 76 7732 8878 7234 3426 -284 1009 C

ATOM 423 OE1 GLU A 76 17.405 33. .113 -12. .371 1. .00 63. , 94 O

ANISOU 423 OE1 GLU A 76 7707 9417 7172 3457 -435 1040 O

ATOM 424 OE2 GLU A 76 17.240 34. .663 -10. .800 1. .00 65. , 04 O

ANISOU 424 OE2 GLU A 76 8352 8849 7511 3779 -91 1215 O

ATOM 425 N THR A 77 21.186 31. .039 -9. .589 1. .00 50. , 58 N

ANISOU 425 N THR A 77 6324 6557 6337 1793 -267 268 N

ATOM 426 CA THR A 77 22.091 31. .380 -8. .492 1. .00 48. , 97 C

ANISOU 426 CA THR A 77 6372 5943 6293 1595 -129 178 C

ATOM 427 C THR A 77 23.549 31. .113 -8. .847 1. .00 47. , 39 C

ANISOU 427 C THR A 77 6286 5591 6128 1252 -112 66 C

ATOM 428 O THR A 77 24.431 31. .728 -8. .288 1. .00 47. ,21 O

ANISOU 428 O THR A 77 6511 5254 6173 1108 24 11 O

ATOM 429 CB THR A 77 21.719 30. .596 -7. .210 1. .00 47. , 22 C

ANISOU 429 CB THR A 77 5948 5774 6221 1492 -164 25 C

ATOM 430 OG1 THR A 77 21.675 29. .201 -7. .506 1. .00 45. , 74 0

ANISOU 430 OG1 THR A 77 5446 5851 6082 1284 -306 -106 0

ATOM 431 CG2 THR A 77 20.329 31. .003 -6. .713 1. .00 49. , 13 c

ANISOU 431 CG2 THR A 77 6085 6148 6434 1825 -134 122 c

ATOM 432 N GLY A 78 23.789 30. .206 -9. .787 1. .00 46. , 66 N

ANISOU 432 N GLY A 78 5993 5754 5983 1118 -242 5 N

ATOM 433 CA GLY A 78 25.137 29. ,844 -10. .202 1. .00 45. ,41 C

ANISOU 433 CA GLY A 78 5890 5519 5847 820 -229 -112 C

ATOM 434 C GLY A 78 25.690 28. .747 -9. .318 1. .00 42. , 92 C

ANISOU 434 C GLY A 78 5409 5202 5697 581 -291 -326 C

ATOM 435 O GLY A 78 26.870 28. .361 -9. .422 1. .00 41. , 91 O

ANISOU 435 O GLY A 78 5289 5028 5605 354 -283 -450 O

ATOM 436 N GLU A 79 24.811 28. .250 -8. .439 1. .00 42. , 37 N

ANISOU 436 N GLU A 79 5187 5200 5713 660 -335 -351 N

ATOM 437 CA GLU A 79 25.074 27. .128 -7. .526 1. .00 40. , 64 C

ANISOU 437 CA GLU A 79 4823 4985 5633 508 -370 -492 C

ATOM 438 C GLU A 79 25.283 25. .864 -8. .297 1. .00 40. ,09 C

ANISOU 438 C GLU A 79 4556 5079 5595 359 -457 -606 C

ATOM 439 O GLU A 79 24.644 25. ,650 -9. .306 1. .00 41. , 14 O

ANISOU 439 O GLU A 79 4558 5420 5653 397 -524 -604 O

ATOM 440 CB GLU A 79 23.897 26. .910 -6. .586 1. .00 40. , 91 C

ANISOU 440 CB GLU A 79 4741 5075 5729 637 -358 -456 C

ATOM 441 CG GLU A 79 23.541 28. .090 -5. .718 1. .00 41. , 78 c

ANISOU 441 CG GLU A 79 5035 5031 5809 817 -257 -370 c

ATOM 442 CD GLU A 79 22.837 27. .688 -4. .443 1. .00 41. , 64 c

ANISOU 442 CD GLU A 79 4920 5041 5861 875 -216 -382 c

ATOM 443 OE1 GLU A 79 21.655 27. .293 -4. .530 1. .00 42. , 53 0

ANISOU 443 OE1 GLU A 79 4821 5349 5989 971 -233 -342 0

ATOM 444 OE2 GLU A 79 23.463 27. .779 -3. .348 1. .00 41. , 03 0

ANISOU 444 OE2 GLU A 79 4959 4828 5801 821 -160 -441 0

ATOM 445 N THR A 80 26.192 25. .032 -7. .823 1. .00 38. ,86 N

ANISOU 445 N THR A 80 4382 4848 5536 211 -452 -719 N

ATOM 446 CA THR A 80 26.378 23. .712 -8. .387 1. .00 38. , 67 C

ANISOU 446 CA THR A 80 4202 4912 5580 87 -494 -845 C

ATOM 447 C THR A 80 25.890 22. .747 -7. .349 1. .00 38. , 48 C

ANISOU 447 C THR A 80 4096 4822 5700 80 -449 -860 C

ATOM 448 O THR A 80 26.365 22. .784 -6. .198 1. .00 37. , 87 0

ANISOU 448 O THR A 80 4110 4623 5655 123 -401 -819 0

ATOM 449 CB THR A 80 27.846 23. .420 -8. .659 1. .00 38. , 05 c

ANISOU 449 CB THR A 80 4175 4785 5499 -25 -488 -942 c

ATOM 450 OG1 THR A 80 28.262 24. .211 -9. .760 1. .00 38. , 66 0

ANISOU 450 OG1 THR A 80 4320 4931 5438 -53 -493 -925 0

ATOM 451 CG2 THR A 80 28.030 21. .981 -9. .004 1. .00 38. ,16 c

ANISOU 451 CG2 THR A 80 4064 4822 5612 -110 -494 - 1076 c ATOM 452 N CYS A 81 24.948 21..892 -7..741 1..00 39..45 N

ANISOU 452 N CYS A 81 4048 5045 5896 16 -450 -928 N

ATOM 453 CA CYS A 81 24.277 21. .057 -6. .769 1. .00 39. .92 C

ANISOU 453 CA CYS A 81 4044 5022 6100 -11 -353 -916 C

ATOM 454 C CYS A 81 24.414 19. .586 -7. .040 1. .00 40. .73 C

ANISOU 454 C CYS A 81 4084 5036 6356 -177 -282 - 1055 C

ATOM 455 O CYS A 81 23.851 19. .055 -7. .999 1. .00 42. .07 O

ANISOU 455 O CYS A 81 4097 5332 6553 -319 -302 - 1214 O

ATOM 456 CB CYS A 81 22.809 21. .422 -6. .697 1. .00 41. .19 C

ANISOU 456 CB CYS A 81 4047 5357 6245 39 -351 -878 C

ATOM 457 SG CYS A 81 22.547 23. .054 -5. .985 1. .00 40. .80 S

ANISOU 457 SG CYS A 81 4132 5309 6062 292 -359 -695 s

ATOM 458 N ILE A 82 25.140 18. .911 -6. .154 1. .00 40. .43 N

ANISOU 458 N ILE A 82 4173 4783 6407 -143 -184 - 1001 N

ATOM 459 CA ILE A 82 25.376 17. .487 -6. .287 1. .00 41. .68 C

ANISOU 459 CA ILE A 82 4347 4762 6730 -250 -62 - 1099 C

ATOM 460 C ILE A 82 24.337 16. .709 -5. .529 1. .00 43. .39 C

ANISOU 460 C ILE A 82 4534 4849 7104 -332 120 - 1055 C

ATOM 461 O ILE A 82 24.185 16. .883 -4. .317 1. .00 43. .28 O

ANISOU 461 O ILE A 82 4604 4764 7076 -206 199 -869 O

ATOM 462 CB ILE A 82 26.731 17. .110 -5. .716 1. .00 41. .20 C

ANISOU 462 CB ILE A 82 4446 4546 6662 -103 -29 - 1028 c

ATOM 463 CGI ILE A 82 27.826 17. .375 -6. .746 1. .00 40. .45 c

ANISOU 463 CGI ILE A 82 4339 4554 6475 -109 -145 - 1153 c

ATOM 464 CG2 ILE A 82 26.711 15. .663 -5. .252 1. .00 43. .15 c

ANISOU 464 CG2 ILE A 82 4785 4516 7094 -Ill 178 - 1009 c

ATOM 465 CD1 ILE A 82 29.150 17. .704 -6. .103 1. .00 39. .69 c

ANISOU 465 CD1 ILE A 82 4324 4478 6279 63 -186 - 1077 c

ATOM 466 N SER A 83 23.592 15. .894 -6. .260 1. .00 45. .35 N

ANISOU 466 N SER A 83 4650 5094 7486 -567 196 - 1249 N

ATOM 467 CA SER A 83 22.628 15. ,017 -5. .647 1. .00 47. .69 C

ANISOU 467 CA SER A 83 4913 5238 7970 -726 424 - 1250 C

ATOM 468 C SER A 83 23.453 13. .966 -4. .948 1. .00 48. .58 C

ANISOU 468 C SER A 83 5285 4959 8214 -648 629 - 1138 C

ATOM 469 O SER A 83 24.501 13. .560 -5. .442 1. .00 48. .32 0

ANISOU 469 O SER A 83 5363 4810 8186 -581 602 - 1203 0

ATOM 470 CB SER A 83 21.759 14. .375 -6. .706 1. .00 50. .14 c

ANISOU 470 CB SER A 83 5001 5661 8391 -1047 460 - 1559 c

ATOM 471 OG SER A 83 22.559 13. .563 -7. .545 1. .00 50. .85 0

ANISOU 471 OG SER A 83 5180 5586 8553 -1139 486 - 1752 0

ATOM 472 N ALA A 84 22.985 13. .535 -3. .792 1. .00 49. .99 N

ANISOU 472 N ALA A 84 5563 4951 8478 -620 848 -950 N

ATOM 473 CA ALA A 84 23.750 12. .593 -3. .016 1. .00 51. .34 C

ANISOU 473 CA ALA A 84 6013 4763 8730 -459 1059 -768 C

ATOM 474 C ALA A 84 23.208 11. .195 -3. .249 1. .00 55. .04 C

ANISOU 474 C ALA A 84 6558 4870 9485 -732 1383 -891 C

ATOM 475 O ALA A 84 21.997 10. .977 -3. .235 1. .00 56. .98 O

ANISOU 475 O ALA A 84 6658 5132 9860 -1025 1531 -991 0

ATOM 476 CB ALA A 84 23.684 12. ,962 -1. .546 1. .00 51. .15 c

ANISOU 476 CB ALA A 84 6104 4748 8583 -218 1129 -451 c

ATOM 477 N ASN A 85 24.113 10. .260 -3. .476 1. .00 56. .44 N

ANISOU 477 N ASN A 85 6954 4724 9765 -641 1509 -905 N

ATOM 478 CA ASN A 85 23.733 8. .875 -3. .686 1. .00 60. .55 C

ANISOU 478 CA ASN A 85 7625 4799 10584 -890 1871 - 1030 C

ATOM 479 C ASN A 85 24.179 8. .001 -2. .547 1. .00 63. .13 C

ANISOU 479 C ASN A 85 8319 4684 10985 -623 2195 -683 C

ATOM 480 O ASN A 85 25.345 8. .043 -2. .151 1. .00 62. .23 O

ANISOU 480 O ASN A 85 8372 4554 10720 -203 2110 -469 O

ATOM 481 CB ASN A 85 24.322 8. .342 -4. .986 1. .00 61. .22 c

ANISOU 481 CB ASN A 85 7707 4796 10758 -1005 1828 - 1363 c

ATOM 482 CG ASN A 85 23.513 8. ,755 -6. .185 1. .00 60. .84 c ANISOU 482 CG ASN A 85 7317 5101 10699 -1381 1645 - 1757 C

ATOM 483 OD1 ASN A 85 22.400 9. .297 -6. , 049 1. .00 60. ,71 O

ANISOU 483 OD1 ASN A 85 7057 5359 10651 -1577 1592 - 1792 O

ATOM 484 ND2 ASN A 85 24.057 8. .502 -7. , 376 1. .00 61. , 05 N

ANISOU 484 ND2 ASN A 85 7305 5168 10723 -1457 1549 - 2058 N

ATOM 485 N PRO A 86 23.244 7. .203 -2. ,017 1. .00 66. , 84 N

ANISOU 485 N PRO A 86 8905 4819 11674 -862 2582 -621 N

ATOM 486 CA PRO A 86 21.849 7. .192 -2. ,468 1. .00 68. , 33 C

ANISOU 486 CA PRO A 86 8820 5117 12024 -1383 2671 -912 C

ATOM 487 C PRO A 86 21.082 8. .414 -1. , 950 1. .00 65. , 69 C

ANISOU 487 C PRO A 86 8197 5280 11482 -1363 2450 -810 C

ATOM 488 O PRO A 86 21.506 9. .035 -0. , 975 1. .00 63. , 72 O

ANISOU 488 O PRO A 86 8048 5147 11015 -991 2354 -474 O

ATOM 489 CB PRO A 86 21.298 5. .925 -1. , 824 1. .00 73. , 65 C

ANISOU 489 CB PRO A 86 9774 5219 12989 -1587 3219 -802 C

ATOM 490 CG PRO A 86 22.098 5. .772 -0. , 574 1. .00 73. , 87 C

ANISOU 490 CG PRO A 86 10166 5023 12876 -1067 3346 -287 C

ATOM 491 CD PRO A 86 23.462 6. .324 -0. , 857 1. .00 70. , 24 C

ANISOU 491 CD PRO A 86 9725 4791 12173 -619 2968 -232 C

ATOM 492 N LEU A 87 19.970 8. .752 -2. , 598 1. .00 66. ,09 N

ANISOU 492 N LEU A 87 7884 5644 11583 -1740 2372 - 1114 N

ATOM 493 CA LEU A 87 19.204 9. .949 -2. , 251 1. .00 63. , 95 C

ANISOU 493 CA LEU A 87 7316 5865 11115 -1688 2156 - 1050 C

ATOM 494 C LEU A 87 18.479 9. .871 -0. , 913 1. .00 65. , 78 C

ANISOU 494 C LEU A 87 7613 6015 11367 -1669 2439 -763 C

ATOM 495 O LEU A 87 18.456 10. .865 -0. ,169 1. .00 63. , 40 O

ANISOU 495 O LEU A 87 7269 5987 10833 -1382 2278 -539 O

ATOM 496 CB LEU A 87 18.205 10. .290 -3. , 355 1. .00 64. , 59 C

ANISOU 496 CB LEU A 87 6959 6367 11215 -2038 1992 - 1450 C

ATOM 497 N ASN A 88 17.899 8. .709 -0. , 602 1. .00 70. , 35 N

ANISOU 497 N ASN A 88 8310 6205 12215 -1983 2886 -778 N

ATOM 498 CA ASN A 88 17.039 8. .603 0. .583 1 , .00 72. .81 C

ANISOU 498 CA ASN A 88 8639 6472 12552 -2039 3203 -533 C

ATOM 499 C ASN A 88 17.266 7. .388 1. .478 1. .00 76. ,89 C

ANISOU 499 C ASN A 88 9604 6369 13242 -2028 3713 -234 C

ATOM 500 O ASN A 88 17.729 6. .343 1. .029 1 , .00 79. .40 O

ANISOU 500 O ASN A 88 10177 6208 13782 -2151 3936 -321 O

ATOM 501 CB ASN A 88 15.579 8. .594 0. .152 1 , .00 75. .53 C

ANISOU 501 CB ASN A 88 8544 7109 13046 -2541 3304 -867 C

ATOM 502 CG ASN A 88 15.232 7. .370 -0. , 664 1. .00 79. , 99 c

ANISOU 502 CG ASN A 88 9094 7345 13953 -3073 3599 - 1237 c

ATOM 503 OD1 ASN A 88 15.744 6. .278 -0. , 421 1. .00 82. , 77 0

ANISOU 503 OD1 ASN A 88 9858 7081 14508 -3120 3958 - 1126 0

ATOM 504 ND2 ASN A 88 14.347 7. .543 -1. , 637 1. .00 81. , 22 N

ANISOU 504 ND2 ASN A 88 8775 7921 14163 -3467 3459 - 1693 N

ATOM 505 N VAL A 89 16.879 7. .528 2. .740 1 , .00 78. .06 N

ANISOU 505 N VAL A 89 9854 6524 13279 -1875 3927 121 N

ATOM 506 CA VAL A 89 16.847 6. .413 3. .666 1 , .00 82. .85 C

ANISOU 506 CA VAL A 89 10872 6576 14029 -1885 4476 448 C

ATOM 507 C VAL A 89 15.385 6. .130 3. .969 1 , .00 86. .95 C

ANISOU 507 C VAL A 89 11164 7133 14741 -2387 4856 344 C

ATOM 508 O VAL A 89 14.639 7. .040 4. .319 1 , .00 85. .50 O

ANISOU 508 O VAL A 89 10640 7454 14390 -2385 4703 331 O

ATOM 509 CB VAL A 89 17.580 6. .748 4. .967 1 , .00 81. .74 C

ANISOU 509 CB VAL A 89 11043 6457 13559 -1288 4460 971 C

ATOM 510 CGI VAL A 89 17.424 5. ,629 5. , 975 1. .00 87. , 36 C

ANISOU 510 CGI VAL A 89 12186 6630 14376 -1267 5063 1367 C

ATOM 511 CG2 VAL A 89 19.046 7. .038 4. .692 1 , .00 78. .18 C

ANISOU 511 CG2 VAL A 89 10757 6041 12907 -808 4083 1042 c

ATOM 512 N PRO A 90 14.965 4. .867 3. .821 1 , .00 92. .53 N

ANISOU 512 N PRO A 90 12051 7299 15809 -2833 5377 247 N ATOM 513 CA PRO A 90 13.542 4..560 3..907 1..00 96..99 C

ANISOU 513 CA PRO A 90 12315 7937 16599 -3431 5743 33 C

ATOM 514 C PRO A 90 12.979 4. .656 5. .314 1. .00 99. .24 C

ANISOU 514 C PRO A 90 12706 8246 16756 -3311 6085 466 C

ATOM 515 O PRO A 90 13.733 4. .636 6. .304 1. .00 98. .71 O

ANISOU 515 O PRO A 90 13067 7973 16464 -2787 6163 976 O

ATOM 516 CB PRO A 90 13.459 3. .119 3. .404 1. .00102. .79 C

ANISOU 516 CB PRO A 90 13314 7975 17765 -3925 6252 -178 C

ATOM 517 CG PRO A 90 14.711 2. .900 2. .625 1. .00100. .22 C

ANISOU 517 CG PRO A 90 13249 7395 17434 -3634 5988 -251 C

ATOM 518 CD PRO A 90 15.748 3. .728 3. .317 1. .00 95. .09 C

ANISOU 518 CD PRO A 90 12786 6965 16378 -2871 5614 207 C

ATOM 519 N ARG A 91 11.650 4. .754 5. .386 1. .00102. .15 N

ANISOU 519 N ARG A 91 12653 8917 17243 -3791 6287 244 N

ATOM 520 CA ARG A 91 10.925 4. .775 6. .653 1. .00105. .24 C

ANISOU 520 CA ARG A 91 13083 9358 17545 -3784 6683 593 C

ATOM 521 C ARG A 91 10.976 3. .383 7. .311 1. .00111. .79 C

ANISOU 521 C ARG A 91 14473 9374 18628 -3979 7424 911 C

ATOM 522 O ARG A 91 10.711 2. .364 6. .659 1. .00116. .30 O

ANISOU 522 O ARG A 91 15113 9475 19599 -4529 7787 617 O

ATOM 523 CB ARG A 91 9.474 5. .213 6. .442 1. .00107. .15 C

ANISOU 523 CB ARG A 91 12665 10179 17866 -4273 6712 218 C

ATOM 524 CG ARG A 91 9.324 6. .645 5. .955 1. .00101. .51 C

ANISOU 524 CG ARG A 91 11439 10263 16867 -3992 6045 -4 c

ATOM 525 CD ARG A 91 7.890 7. .051 5. .653 1. ,00103. , 96 c

ANISOU 525 CD ARG A 91 11056 11200 17244 -4419 6054 -392 c

ATOM 526 NE ARG A 91 7.052 7. .033 6. .849 1. .00107. .63 N

ANISOU 526 NE ARG A 91 11472 11761 17662 -4485 6491 -129 N

ATOM 527 CZ ARG A 91 5.743 7. .234 6. .844 1. .00111. .10 C

ANISOU 527 CZ ARG A 91 11331 12711 18170 -4867 6637 -401 C

ATOM 528 NH1 ARG A 91 5.109 7. .465 5. .701 1. .00111. .53 N

ANISOU 528 NH1 ARG A 91 10790 13259 18327 -5201 6358 -947 N

ATOM 529 NH2 ARG A 91 5.060 7. .200 7. .981 1. .00114. .53 N

ANISOU 529 NH2 ARG A 91 11757 13215 18546 -4900 7064 -132 N

ATOM 530 N LYS A 92 11.321 3. .353 8. .597 1. .00112. .72 N

ANISOU 530 N LYS A 92 15004 9329 18497 -3518 7659 1506 N

ATOM 531 CA LYS A 92 11.432 2. .115 9. .368 1. .00119. .21 C

ANISOU 531 CA LYS A 92 16431 9382 19481 -3565 8379 1935 C

ATOM 532 C LYS A 92 11.623 2. .505 10. .836 1. .00119. .30 C

ANISOU 532 C LYS A 92 16711 9553 19064 -2986 8485 2560 C

ATOM 533 O LYS A 92 12.011 3. .641 11. .130 1. .00113. .78 O

ANISOU 533 O LYS A 92 15823 9448 17960 -2488 7942 2634 O

ATOM 534 CB LYS A 92 12.595 1. .249 8. .851 1. .00119. .78 C

ANISOU 534 CB LYS A 92 17025 8776 19710 -3356 8428 2012 C

ATOM 535 N HIS A 93 11.298 1. .593 11. .755 1. .00126. .00 N

ANISOU 535 N HIS A 93 17988 9892 19993 -3079 9204 2988 N

ATOM 536 CA HIS A 93 11.640 1. .751 13. .177 1. .00127. .17 C

ANISOU 536 CA HIS A 93 18514 10105 19700 -2463 9369 3652 C

ATOM 537 C HIS A 93 13.016 1. .142 13. .357 1. .00127. .56 C

ANISOU 537 C HIS A 93 19201 9648 19619 -1845 9371 4077 C

ATOM 538 O HIS A 93 13.152 -0. ,060 13. , 618 1. ,00133. , 91 O

ANISOU 538 O HIS A 93 20561 9684 20634 -1894 10001 4406 O

ATOM 539 CB HIS A 93 10.581 1. ,101 14. , 078 1. , 00134. , 66 C

ANISOU 539 CB HIS A 93 19603 10799 20762 -2847 10165 3932 C

ATOM 540 N TRP A 94 14.036 1. .990 13. .206 1. .00121. .15 N

ANISOU 540 N TRP A 94 18298 9275 18458 -1257 8677 4060 N

ATOM 541 CA TRP A 94 15.400 1. .588 12. .880 1. .00119. .93 C

ANISOU 541 CA TRP A 94 18528 8796 18245 -754 8471 4214 C

ATOM 542 C TRP A 94 16.225 1. .233 14. .083 1. .00123. .02 C

ANISOU 542 C TRP A 94 19474 9042 18225 -2 8672 4919 C

ATOM 543 O TRP A 94 17.303 0. .652 13. .944 1. .00123. .98 O ANISOU 543 O TRP A 94 19990 8803 18315 446 8654 5139 O

ATOM 544 CB TRP A 94 16.094 2. .730 12. .143 1. .00111. .92 C

ANISOU 544 CB TRP A 94 17098 8391 17035 -515 7635 3834 C

ATOM 545 CG TRP A 94 15.771 2. .900 10. .671 1. .00108. .81 C

ANISOU 545 CG TRP A 94 16278 8042 17021 -1076 7353 3169 C

ATOM 546 CD1 TRP A 94 14.796 3. .711 10. .089 1. .00105. .94 C

ANISOU 546 CD1 TRP A 94 15312 8185 16756 -1550 7095 2684 C

ATOM 547 CD2 TRP A 94 16.462 2. .285 9. .540 1. .00108. .38 C

ANISOU 547 CD2 TRP A 94 16348 7573 17258 -1170 7265 2899 C

ATOM 548 NE1 TRP A 94 14.831 3. .626 8. .723 1. .00104. .00 N

ANISOU 548 NE1 TRP A 94 14820 7888 16808 -1919 6857 2164 N

ATOM 549 CE2 TRP A 94 15.800 2. .787 8. .329 1. .00105. .25 C

ANISOU 549 CE2 TRP A 94 15392 7499 17101 -1739 6951 2246 C

ATOM 550 CE3 TRP A 94 17.515 1. .393 9. .411 1. .00110. .60 C

ANISOU 550 CE3 TRP A 94 17127 7290 17607 -822 7421 3124 C

ATOM 551 CZ2 TRP A 94 16.195 2. .399 7. .067 1. .00104. .38 C

ANISOU 551 CZ2 TRP A 94 15238 7157 17265 -1968 6804 1835 C

ATOM 552 CZ3 TRP A 94 17.906 1. .010 8. .126 1. .00109. .59 C

ANISOU 552 CZ3 TRP A 94 16950 6899 17789 -1061 7282 2691 C

ATOM 553 CH2 TRP A 94 17.261 1. .504 6. .983 1. ,00106. ,49 C

ANISOU 553 CH2 TRP A 94 16022 6834 17607 -1636 6979 2054 c

ATOM 554 N TRP A 95 15.738 1. .582 15. .274 1. .00124. .93 N

ANISOU 554 N TRP A 95 19738 9610 18118 181 8859 5279 N

ATOM 555 CA TRP A 95 16.529 1. .424 16. .493 1. .00127. .66 C

ANISOU 555 CA TRP A 95 20545 10013 17947 974 8959 5945 C

ATOM 556 C TRP A 95 15.758 0. .982 17. .711 1. .00134. .23 C

ANISOU 556 C TRP A 95 21671 10707 18621 970 9626 6457 C

ATOM 557 O TRP A 95 14.541 1. .188 17. .812 1. .00135. .33 O

ANISOU 557 O TRP A 95 21515 10971 18933 394 9887 6265 O

ATOM 558 CB TRP A 95 17.285 2. .709 16. .797 1. .00121. .40 C

ANISOU 558 CB TRP A 95 19446 10065 16614 1527 8202 5866 c

ATOM 559 CG TRP A 95 18.494 2. .506 17. .677 1. .00123. .45 c

ANISOU 559 CG TRP A 95 20121 10429 16354 2405 8121 6414 c

ATOM 560 CD1 TRP A 95 19.443 1. .502 17. .577 1. .00127. .03 c

ANISOU 560 CD1 TRP A 95 21063 10357 16846 2832 8313 6755 c

ATOM 561 CD2 TRP A 95 18.938 3. .336 18. .806 1. .00122. .54 c

ANISOU 561 CD2 TRP A 95 19953 11050 15557 3022 7805 6671 c

ATOM 562 NE1 TRP A 95 20.410 1. .643 18. .535 1. .00128. .46 N

ANISOU 562 NE1 TRP A 95 21461 10932 16417 3670 8128 7213 N

ATOM 563 CE2 TRP A 95 20.171 2. .721 19. .304 1. .00125. .93 C

ANISOU 563 CE2 TRP A 95 20828 11384 15636 3802 7814 7168 C

ATOM 564 CE3 TRP A 95 18.458 4. .483 19. .426 1. .00119. .78 C

ANISOU 564 CE3 TRP A 95 19241 11416 14855 3019 7532 6521 C

ATOM 565 CZ2 TRP A 95 20.872 3. ,243 20. , 381 1. ,00126. , 59 c

ANISOU 565 CZ2 TRP A 95 20949 12130 15021 4516 7538 7476 c

ATOM 566 CZ3 TRP A 95 19.173 5. .000 20. .516 1. .00120. .40 c

ANISOU 566 CZ3 TRP A 95 19398 12095 14252 3714 7280 6818 c

ATOM 567 CH2 TRP A 95 20.353 4. .394 20. .978 1. .00123. .74 c

ANISOU 567 CH2 TRP A 95 20216 12476 14325 4433 7269 7272 c

ATOM 568 N THR A 96 16.479 0. .365 18. .648 1. .00139. .04 N

ANISOU 568 N THR A 96 22860 11094 18877 1646 9914 7129 N

ATOM 569 CA THR A 96 15.917 -0. ,101 19. , 921 1. , 00146. , 04 C

ANISOU 569 CA THR A 96 24124 11853 19511 1787 10572 7738 C

ATOM 570 C THR A 96 15.616 1. .050 20. .890 1. .00143. .53 C

ANISOU 570 C THR A 96 23473 12444 18619 2048 10260 7788 C

ATOM 571 O THR A 96 16.224 2. .126 20. .807 1. .00137. .18 O

ANISOU 571 O THR A 96 22307 12339 17478 2382 9521 7514 0

ATOM 572 CB THR A 96 16.884 -1. ,074 20. , 620 1. , 00152. , 24 c

ANISOU 572 CB THR A 96 25648 12181 20014 2558 10930 8484 c

ATOM 573 OG1 THR A 96 17.147 -2. ,197 19. , 770 1. ,00155. , 43 0

ANISOU 573 OG1 THR A 96 26427 11663 20965 2344 11297 8458 0 ATOM 574 CG2 THR A 96 16.288 -1.,540 21.,943 1.,00159.,89 C

ANISOU 574 CG2 THR A 96 27034 13035 20684 2724 11637 9154 C

ATOM 575 N ASP A 97 14.682 0. .813 21. .811 1. .00148. .98 N

ANISOU 575 N ASP A 97 24299 13103 19201 1879 10859 8126 N

ATOM 576 CA ASP A 97 14.282 1. .825 22. .795 1. .00147. .67 C

ANISOU 576 CA ASP A 97 23851 13762 18495 2099 10666 8180 C

ATOM 577 C ASP A 97 14.569 1. .460 24. .265 1. .00154. .16 C

ANISOU 577 C ASP A 97 25192 14693 18688 2787 11062 8963 C

ATOM 578 O ASP A 97 13.982 2. .056 25. .175 1. .00155. .21 O

ANISOU 578 O ASP A 97 25168 15378 18425 2855 11138 9066 O

ATOM 579 CB ASP A 97 12.788 2. .156 22. .635 1. .00147. .80 C

ANISOU 579 CB ASP A 97 23407 13905 18846 1295 10939 7798 C

ATOM 580 N SER A 98 15.477 0. .517 24. .498 1. .00158. .71 N

ANISOU 580 N SER A 98 26376 14790 19138 3340 11301 9512 N

ATOM 581 CA SER A 98 15.607 -0. ,130 25. ,808 1. ,00166. , 87 C

ANISOU 581 CA SER A 98 28006 15736 19661 3933 11868 10346 C

ATOM 582 C SER A 98 15.917 0. ,796 26. ,990 1. ,00166. , 22 C

ANISOU 582 C SER A 98 27791 16643 18720 4600 11494 10551 C

ATOM 583 O SER A 98 15.314 0. .668 28. .058 1. .00171. .79 O

ANISOU 583 O SER A 98 28704 17497 19071 4707 11992 10995 O

ATOM 584 CB SER A 98 16.648 -1. ,245 25. ,739 1. , 00171. , 63 C

ANISOU 584 CB SER A 98 29263 15682 20265 4512 12105 10875 C

ATOM 585 OG SER A 98 17.924 -0. ,703 25. ,455 1. ,00166. , 40 0

ANISOU 585 OG SER A 98 28423 15519 19281 5133 11302 10700 0

ATOM 586 N SER A 99 16.855 1. .721 26. .804 1. .00159. .86 N

ANISOU 586 N SER A 99 26644 16521 17576 5026 10643 10209 N

ATOM 587 CA SER A 99 17.237 2. .613 27. .902 1. .00159. .56 C

ANISOU 587 CA SER A 99 26470 17448 16708 5651 10256 10328 C

ATOM 588 C SER A 99 16.097 3. .566 28. .230 1. .00157. .25 C

ANISOU 588 C SER A 99 25720 17655 16373 5168 10248 9955 C

ATOM 589 O SER A 99 15.438 4. .079 27. .328 1. .00151. .89 O

ANISOU 589 O SER A 99 24577 16910 16224 4480 10061 9337 O

ATOM 590 CB SER A 99 18.500 3. .405 27. .562 1. .00153. .58 C

ANISOU 590 CB SER A 99 25413 17291 15649 6122 9363 9964 c

ATOM 591 OG SER A 99 18.276 4. .264 26. .466 1. .00145. .38 0

ANISOU 591 OG SER A 99 23808 16352 15076 5525 8851 9177 0

ATOM 592 N ALA A 100 15.865 3. .803 29. .517 1. .00161. .65 N

ANISOU 592 N ALA A 100 26404 18742 16276 5563 10455 10332 N

ATOM 593 CA ALA A 100 14.859 4. ,768 29. ,923 1. ,00159. , 82 C

ANISOU 593 CA ALA A 100 25740 19062 15924 5210 10428 9980 C

ATOM 594 C ALA A 100 15.283 6. .104 29. .343 1. .00151. .15 C

ANISOU 594 C ALA A 100 24062 18570 14797 5172 9542 9228 C

ATOM 595 O ALA A 100 14.477 6. .843 28. .775 1. .00146. .54 O

ANISOU 595 O ALA A 100 23002 18092 14585 4597 9386 8662 O

ATOM 596 CB ALA A 100 14.767 4. .842 31. .435 1. .00166. .05 c

ANISOU 596 CB ALA A 100 26782 20406 15904 5770 10716 10504 c

ATOM 597 N GLU A 101 16.575 6. .386 29. .475 1. .00149. .47 N

ANISOU 597 N GLU A 101 23898 18751 14141 5803 8983 9236 N

ATOM 598 CA GLU A 101 17.178 7. .524 28. .817 1. .00141. .73 C

ANISOU 598 CA GLU A 101 22442 18226 13183 5769 8169 8551 C

ATOM 599 C GLU A 101 17.243 7. .218 27. .332 1. .00136. .94 C

ANISOU 599 C GLU A 101 21698 16973 13360 5257 8032 8203 C

ATOM 600 O GLU A 101 17.441 6. .075 26. .941 1. .00139. .92 O

ANISOU 600 O GLU A 101 22437 16667 14061 5240 8393 8552 O

ATOM 601 CB GLU A 101 18.585 7. .774 29. .361 1. .00142. .31 c

ANISOU 601 CB GLU A 101 22605 18890 12579 6555 7665 8668 c

ATOM 602 N LYS A 102 17.056 8. .243 26. .510 1. .00129. .95 N

ANISOU 602 N LYS A 102 20311 16296 12768 4853 7536 7517 N

ATOM 603 CA LYS A 102 17.205 8. .118 25. .072 1. .00124. .98 C

ANISOU 603 CA LYS A 102 19500 15191 12797 4412 7305 7125 C

ATOM 604 C LYS A 102 18.461 8. .882 24. .692 1. .00119. .97 C ANISOU 604 C LYS A 102 18670 14973 11941 4750 6560 6779 C

ATOM 605 O LYS A 102 18.659 10. .001 25. .154 1. .00117. .67 O

ANISOU 605 O LYS A 102 18124 15345 11242 4932 6152 6488 O

ATOM 606 CB LYS A 102 15.984 8. .702 24. .361 1. .00121. .38 C

ANISOU 606 CB LYS A 102 18606 14672 12841 3695 7331 6622 C

ATOM 607 N LYS A 103 19.304 8. ,284 23. ,857 1. , 00118. , 68 N

ANISOU 607 N LYS A 103 18624 14418 12051 4815 6410 6788 N

ATOM 608 CA LYS A 103 20.592 8. .890 23. .502 1. .00114. .73 C

ANISOU 608 CA LYS A 103 17948 14310 11334 5149 5748 6498 C

ATOM 609 C LYS A 103 20.822 8. .980 21. .997 1. .00109. .13 C

ANISOU 609 C LYS A 103 17007 13235 11221 4721 5449 6038 C

ATOM 610 O LYS A 103 20.241 8. .206 21. .224 1. .00109. .53 O

ANISOU 610 O LYS A 103 17150 12632 11832 4291 5794 6060 O

ATOM 611 CB LYS A 103 21.739 8. .115 24. .160 1. .00119. .63 C

ANISOU 611 CB LYS A 103 18940 15024 11490 5890 5778 7019 C

ATOM 612 N HIS A 104 21.679 9. .916 21. .591 1. .00104. .40 N

ANISOU 612 N HIS A 104 16110 13071 10486 4826 4830 5610 N

ATOM 613 CA HIS A 104 21.992 10. .118 20. .180 1. .00 99. .09 C

ANISOU 613 CA HIS A 104 15206 12140 10303 4465 4508 5168 C

ATOM 614 C HIS A 104 22.641 8. .915 19. .577 1. .00100. .99 C

ANISOU 614 C HIS A 104 15725 11838 10807 4594 4673 5419 C

ATOM 615 O HIS A 104 23.454 8. .253 20. .215 1. .00105. .23 O

ANISOU 615 O HIS A 104 16556 12428 10999 5167 4760 5844 O

ATOM 616 CB HIS A 104 22.872 11. .348 19. .987 1. .00 94. .61 C

ANISOU 616 CB HIS A 104 14308 12155 9482 4587 3864 4708 C

ATOM 617 CG HIS A 104 22.200 12. .648 20. .365 1. .00 92. .25 c

ANISOU 617 CG HIS A 104 13729 12298 9022 4389 3691 4355 c

ATOM 618 ND1 HIS A 104 21.186 13. .173 19. .661 1. .00 88. .93 N

ANISOU 618 ND1 HIS A 104 13081 11693 9016 3867 3720 4030 N

ATOM 619 CD2 HIS A 104 22.434 13. .519 21. .421 1. .00 93. .35 C

ANISOU 619 CD2 HIS A 104 13793 13081 8597 4691 3496 4273 C

ATOM 620 CE1 HIS A 104 20.795 14. .321 20. .221 1. .00 87. .91 C

ANISOU 620 CE1 HIS A 104 12763 12017 8624 3862 3567 3777 C

ATOM 621 NE2 HIS A 104 21.558 14. .534 21. .302 1. .00 90. .59 N

ANISOU 621 NE2 HIS A 104 13203 12847 8372 4342 3437 3906 N

ATOM 622 N VAL A 105 22.258 8. .602 18. .348 1. .00 98. .37 N

ANISOU 622 N VAL A 105 15308 10991 11077 4084 4735 5159 N

ATOM 623 CA VAL A 105 22.824 7. .471 17. .641 1. .00100. .09 C

ANISOU 623 CA VAL A 105 15787 10634 11610 4145 4908 5317 C

ATOM 624 C VAL A 105 23.229 7. ,910 16. ,250 1. ,00 94. , 45 C

ANISOU 624 C VAL A 105 14763 9873 11251 3823 4486 4786 C

ATOM 625 O VAL A 105 22.576 8. .736 15. .634 1. .00 90. .16 O

ANISOU 625 O VAL A 105 13877 9455 10924 3352 4287 4354 O

ATOM 626 CB VAL A 105 21.821 6. .314 17. .538 1. .00104. .46 C

ANISOU 626 CB VAL A 105 16646 10452 12592 3786 5588 5582 C

ATOM 627 N TRP A 106 24.324 7. .365 15. .757 1. .00 94. .80 N

ANISOU 627 N TRP A 106 14930 9761 11330 4117 4357 4834 N

ATOM 628 CA TRP A 106 24.743 7. .657 14. .404 1. .00 90. .08 C

ANISOU 628 CA TRP A 106 14074 9084 11067 3823 4012 4364 C

ATOM 629 C TRP A 106 24.209 6. .593 13. .509 1. .00 91. .68 C

ANISOU 629 C TRP A 106 14463 8541 11830 3425 4410 4344 C

ATOM 630 O TRP A 106 24.621 5. .436 13. .584 1. .00 96. .16 O

ANISOU 630 O TRP A 106 15416 8637 12483 3693 4750 4681 O

ATOM 631 CB TRP A 106 26.256 7. .731 14. .310 1. .00 89. .58 C

ANISOU 631 CB TRP A 106 13977 9334 10725 4338 3630 4357 C

ATOM 632 CG TRP A 106 26.848 8. .988 14. .896 1. .00 87. .11 C

ANISOU 632 CG TRP A 106 13361 9816 9923 4574 3139 4167 c

ATOM 633 CD1 TRP A 106 27.869 9. .096 15. .842 1. .00 89. .81 c

ANISOU 633 CD1 TRP A 106 13726 10694 9703 5203 2944 4382 c

ATOM 634 CD2 TRP A 106 26.479 10. .367 14. .585 1. .00 81. .97 c

ANISOU 634 CD2 TRP A 106 12325 9542 9277 4184 2780 3689 c ATOM 635 NEl TRP A 106 28.140 10.,410 16.,126 1.,00 86., 77 N

ANISOU 635 NEl TRP A 106 12997 10965 9005 5163 2508 4028 N

ATOM 636 CE2 TRP A 106 27.347 11. .223 15. .407 1. .00 82. .04 C

ANISOU 636 CE2 TRP A 106 12173 10262 8736 4574 2408 3621 C

ATOM 637 CE3 TRP A 106 25.548 10. .963 13. .744 1. .00 77. .97 C

ANISOU 637 CE3 TRP A 106 11602 8878 9146 3596 2739 3323 C

ATOM 638 CZ2 TRP A 106 27.268 12. .607 15. .361 1. .00 78. .25 C

ANISOU 638 CZ2 TRP A 106 11376 10210 8144 4337 2057 3191 C

ATOM 639 CZ3 TRP A 106 25.476 12. .359 13. .712 1. .00 74. .16 C

ANISOU 639 CZ3 TRP A 106 10809 8847 8522 3435 2375 2948 C

ATOM 640 CH2 TRP A 106 26.317 13. .156 14. .498 1. .00 74. .31 C

ANISOU 640 CH2 TRP A 106 10724 9454 8055 3779 2062 2881 c

ATOM 641 N PHE A 107 23.275 6. .972 12. .651 1. .00 88. .53 N

ANISOU 641 N PHE A 107 13793 8035 11809 2791 4385 3937 N

ATOM 642 CA PHE A 107 22.719 6. .058 11. .664 1. .00 89. .91 C

ANISOU 642 CA PHE A 107 14061 7575 12528 2312 4715 3785 C

ATOM 643 C PHE A 107 23.774 5. .270 10. .887 1. .00 90. .68 C

ANISOU 643 C PHE A 107 14352 7312 12791 2517 4687 3765 C

ATOM 644 O PHE A 107 23.783 4. .036 10. .898 1. .00 95. .64 O

ANISOU 644 O PHE A 107 15380 7317 13643 2567 5162 4020 O

ATOM 645 CB PHE A 107 21.870 6. .833 10. .650 1. .00 85. .44 C

ANISOU 645 CB PHE A 107 13050 7169 12245 1694 4483 3245 c

ATOM 646 CG PHE A 107 21.325 5. .981 9. .538 1. .00 86. .83 c

ANISOU 646 CG PHE A 107 13241 6805 12944 1164 4752 2985 c

ATOM 647 CD1 PHE A 107 20.457 4. .929 9. .811 1. .00 92. .23 c

ANISOU 647 CD1 PHE A 107 14178 6955 13912 862 5365 3162 c

ATOM 648 CD2 PHE A 107 21.671 6. .229 8. .220 1. .00 83. .21 c

ANISOU 648 CD2 PHE A 107 12545 6384 12687 942 4418 2543 c

ATOM 649 CE1 PHE A 107 19.962 4. ,134 8. ,794 1. ,00 94. ,11 c

ANISOU 649 CE1 PHE A 107 14419 6706 14633 327 5627 2858 c

ATOM 650 CE2 PHE A 107 21.171 5. .440 7. .199 1. .00 84. .93 c

ANISOU 650 CE2 PHE A 107 12763 6154 13352 447 4658 2258 c

ATOM 651 CZ PHE A 107 20.315 4. .392 7. .484 1. .00 90. .43 c

ANISOU 651 CZ PHE A 107 13697 6323 14338 125 5258 2390 c

ATOM 652 N GLY A 108 24.667 6. .003 10. .231 1. .00 86. .13 N

ANISOU 652 N GLY A 108 13503 7121 12103 2642 4158 3461 N

ATOM 653 CA GLY A 108 25.732 5. .408 9. .449 1. .00 86. .43 C

ANISOU 653 CA GLY A 108 13649 6929 12260 2856 4071 3390 c

ATOM 654 C GLY A 108 26.694 4. .563 10. .246 1. .00 91. .31 c

ANISOU 654 C GLY A 108 14658 7407 12627 3554 4265 3887 c

ATOM 655 O GLY A 108 27.166 3. .532 9. .772 1. .00 94. .40 0

ANISOU 655 O GLY A 108 15333 7291 13245 3699 4510 3974 0

ATOM 656 N GLU A 109 26.973 4. .998 11. .468 1. .00 92. .44 N

ANISOU 656 N GLU A 109 14822 8020 12281 4015 4164 4210 N

ATOM 657 CA GLU A 109 27.917 4. .305 12. .324 1. .00 97. .45 C

ANISOU 657 CA GLU A 109 15783 8675 12568 4775 4293 4712 C

ATOM 658 C GLU A 109 27.355 2. .988 12. .832 1. .00104. .16 C

ANISOU 658 C GLU A 109 17184 8796 13596 4871 4988 5208 C

ATOM 659 O GLU A 109 28.090 2. .032 13. .020 1. .00109. .00 O

ANISOU 659 O GLU A 109 18168 9095 14155 5410 5224 5576 O

ATOM 660 CB GLU A 109 28.316 5. .192 13. .498 1. .00 97. .16 c

ANISOU 660 CB GLU A 109 15576 9427 11912 5213 3973 4873 c

ATOM 661 N SER A 110 26.052 2. .941 13. .059 1. .00104. .90 N

ANISOU 661 N SER A 110 17334 8620 13903 4358 5340 5222 N

ATOM 662 CA SER A 110 25.444 1. .769 13. .680 1. .00111. .84 C

ANISOU 662 CA SER A 110 18744 8825 14925 4402 6055 5716 C

ATOM 663 C SER A 110 24.128 1. .351 13. .037 1. .00112. .43 C

ANISOU 663 C SER A 110 18837 8300 15580 3563 6483 5454 C

ATOM 664 O SER A 110 23.424 2. .165 12. .433 1. .00107. .47 O

ANISOU 664 O SER A 110 17761 7948 15126 2974 6215 4960 O

ATOM 665 CB SER A 110 25.240 2. .010 15. .174 1. .00114. .89 c ANISOU 665 CB SER A 110 19266 9601 14787 4817 6179 6210 C

ATOM 666 OG SER A 110 26.474 2. .244 15. .821 1. .00115. .73 O

ANISOU 666 OG SER A 110 19375 10270 14328 5627 5830 6470 O

ATOM 667 N MET A 111 23.802 0. .067 13. .166 1. .00119. .07 N

ANISOU 667 N MET A 111 20200 8325 16717 3517 7169 5782 N

ATOM 668 CA MET A 111 22.605 -0. ,472 12. ,546 1. , 00120. , 85 C

ANISOU 668 CA MET A 111 20456 7946 17517 2688 7635 5503 C

ATOM 669 C MET A 111 22.627 -0. ,244 11. ,038 1. ,00116. , 13 C

ANISOU 669 C MET A 111 19489 7320 17314 2166 7298 4809 C

ATOM 670 O MET A 111 21.923 -0. ,922 10. ,300 1. , 00118. , 47 O

ANISOU 670 O MET A 111 19854 7041 18116 1545 7675 4521 O

ATOM 671 CB MET A 111 21.363 0. .171 13. .156 1. .00120. .04 C

ANISOU 671 CB MET A 111 20087 8181 17342 2246 7728 5467 C

ATOM 672 N GLY A 114 22.758 0. .932 8. .787 1. .00105. .57 N

ANISOU 672 N GLY A 114 17303 6517 16291 1478 6404 3673 N

ATOM 673 CA GLY A 114 23.129 2. .331 8. .686 1. .00 98. .72 C

ANISOU 673 CA GLY A 114 15947 6483 15077 1622 5708 3450 C

ATOM 674 C GLY A 114 24.305 2. .548 7. .749 1. .00 95. .24 C

ANISOU 674 C GLY A 114 15373 6209 14606 1860 5259 3181 C

ATOM 675 O GLY A 114 25.257 1. .765 7. .742 1. .00 98. .21 O

ANISOU 675 O GLY A 114 16081 6263 14972 2313 5391 3400 O

ATOM 676 N PHE A 115 24.242 3. .612 6. .954 1. .00 89. .34 N

ANISOU 676 N PHE A 115 14143 5968 13835 1578 4750 2720 N

ATOM 677 CA PHE A 115 25.310 3. .929 6. .009 1. .00 85. .88 C

ANISOU 677 CA PHE A 115 13533 5741 13358 1742 4322 2436 C

ATOM 678 C PHE A 115 25.540 5. .433 5. .926 1. .00 79. .83 C

ANISOU 678 C PHE A 115 12317 5731 12284 1767 3729 2218 C

ATOM 679 O PHE A 115 24.647 6. .222 6. .221 1. .00 77. .83 O

ANISOU 679 O PHE A 115 11833 5773 11967 1499 3642 2140 O

ATOM 680 CB PHE A 115 24.987 3. .367 4. .619 1. ,00 86. , 13 C

ANISOU 680 CB PHE A 115 13511 5381 13834 1222 4432 1979 C

ATOM 681 CG PHE A 115 23.739 3. .939 4. .013 1. .00 83. .80 c

ANISOU 681 CG PHE A 115 12840 5277 13723 548 4351 1574 c

ATOM 682 CD1 PHE A 115 23.739 5. .219 3. .485 1. .00 78. .16 c

ANISOU 682 CD1 PHE A 115 11679 5184 12834 444 3822 1277 c

ATOM 683 CD2 PHE A 115 22.563 3. .199 3. .976 1. .00 87. .81 c

ANISOU 683 CD2 PHE A 115 13435 5356 14571 29 4824 1491 c

ATOM 684 CE1 PHE A 115 22.584 5. .756 2. .938 1. .00 76. .54 c

ANISOU 684 CE1 PHE A 115 11120 5200 12761 -93 3741 937 c

ATOM 685 CE2 PHE A 115 21.411 3. .724 3. .427 1. .00 86. .19 c

ANISOU 685 CE2 PHE A 115 12824 5421 14504 -556 4731 1104 c

ATOM 686 CZ PHE A 115 21.419 5. .004 2. .908 1. .00 80. .55 c

ANISOU 686 CZ PHE A 115 11665 5357 13584 -581 4177 843 c

ATOM 687 N GLN A 116 26.742 5. .822 5. .520 1. .00 77. .36 N

ANISOU 687 N GLN A 116 11888 5715 11792 2089 3350 2114 N

ATOM 688 CA GLN A 116 27.092 7. .230 5. .391 1. .00 72. .20 C

ANISOU 688 CA GLN A 116 10848 5717 10866 2101 2825 1893 C

ATOM 689 C GLN A 116 26.806 7. .694 3. .982 1. .00 68. .62 c

ANISOU 689 C GLN A 116 10105 5321 10647 1623 2604 1408 c

ATOM 690 O GLN A 116 26.889 6. .910 3. .040 1. .00 69. .90 0

ANISOU 690 O GLN A 116 10346 5118 11093 1445 2746 1223 0

ATOM 691 CB GLN A 116 28.551 7. ,442 5. ,744 1. ,00 72. , 03 c

ANISOU 691 CB GLN A 116 10820 6042 10505 2672 2552 2022 c

ATOM 692 CG GLN A 116 28.830 7. .095 7. .188 1. .00 75. .82 c

ANISOU 692 CG GLN A 116 11547 6599 10663 3201 2720 2507 c

ATOM 693 CD GLN A 116 30.129 7. .682 7. .674 1. .00 75. .22 c

ANISOU 693 CD GLN A 116 11315 7114 10152 3712 2345 2556 c

ATOM 694 OE1 GLN A 116 31.208 7. .283 7. .221 1. .00 76. .13 0

ANISOU 694 OE1 GLN A 116 11428 7251 10247 4010 2247 2524 0

ATOM 695 NE2 GLN A 116 30.044 8. .626 8. .611 1. .00 74. .14 N

ANISOU 695 NE2 GLN A 116 11027 7487 9654 3816 2141 2608 N ATOM 696 N PHE A 117 26.459 8..968 3..835 1,.00 64..57 N

ANISOU 696 N PHE A 117 9272 5262 10000 1434 2273 1204 N

ATOM 697 CA PHE A 117 25.991 9. .466 2. .549 1, .00 61. .68 C

ANISOU 697 CA PHE A 117 8634 4984 9818 994 2087 792 C

ATOM 698 C PHE A 117 27.146 9. .721 1. .595 1, .00 59. .51 C

ANISOU 698 C PHE A 117 8253 4865 9493 1099 1795 574 C

ATOM 699 O PHE A 117 28.157 10. .338 1. .952 1, .00 58. .05 O

ANISOU 699 O PHE A 117 8012 5009 9038 1421 1544 639 O

ATOM 700 CB PHE A 117 25.145 10. .722 2. .721 1, .00 58. .82 C

ANISOU 700 CB PHE A 117 8005 5008 9335 801 1885 690 C

ATOM 701 CG PHE A 117 24.126 10. .618 3. .817 1, .00 60. .93 C

ANISOU 701 CG PHE A 117 8346 5225 9581 767 2150 924 C

ATOM 702 CD1 PHE A 117 23.144 9. .627 3. .788 1, .00 64. .36 C

ANISOU 702 CD1 PHE A 117 8877 5274 10301 466 2550 949 C

ATOM 703 CD2 PHE A 117 24.146 11. .510 4. .884 1, .00 59. .93 C

ANISOU 703 CD2 PHE A 117 8186 5441 9145 1010 2025 1093 C

ATOM 704 CE1 PHE A 117 22.209 9. .529 4. .801 1, .00 66. .66 C

ANISOU 704 CE1 PHE A 117 9224 5535 10568 416 2828 1170 C

ATOM 705 CE2 PHE A 117 23.204 11. ,417 5. ,901 1. .00 62. , 12 C

ANISOU 705 CE2 PHE A 117 8527 5699 9379 991 2287 1308 C

ATOM 706 CZ PHE A 117 22.239 10. .423 5. .858 1, .00 65. .46 C

ANISOU 706 CZ PHE A 117 9038 5746 10086 698 2693 1363 c

ATOM 707 N SER A 118 26.981 9. .231 0. .376 1, .00 59. .72 N

ANISOU 707 N SER A 118 8234 4683 9772 801 1843 288 N

ATOM 708 CA SER A 118 27.985 9. .385 -0. ,668 1. .00 58. ,06 C

ANISOU 708 CA SER A 118 7921 4602 9536 852 1612 53 C

ATOM 709 C SER A 118 27.468 10. .333 -1. ,726 1. .00 54. ,89 C

ANISOU 709 C SER A 118 7222 4495 9139 492 1355 -273 C

ATOM 710 O SER A 118 26.288 10. .277 -2. ,089 1. .00 55. , 35 O

ANISOU 710 O SER A 118 7183 4496 9354 133 1448 -417 0

ATOM 711 CB SER A 118 28.332 8. .026 -1. ,300 1. .00 61. , 39 c

ANISOU 711 CB SER A 118 8556 4558 10210 852 1883 -31 c

ATOM 712 OG SER A 118 28.955 8. .172 -2. ,580 1. .00 59. , 87 0

ANISOU 712 OG SER A 118 8214 4496 10039 756 1688 -356 0

ATOM 713 N TYR A 119 28.365 11. .187 -2. ,221 1. .00 52. ,19 N

ANISOU 713 N TYR A 119 6730 4488 8613 598 1048 -385 N

ATOM 714 CA TYR A 119 28.001 12. .253 -3. ,165 1. .00 49. , 36 C

ANISOU 714 CA TYR A 119 6125 4436 8194 340 799 -625 C

ATOM 715 C TYR A 119 28.667 12. .161 -4. ,526 1. .00 48. , 83 C

ANISOU 715 C TYR A 119 5972 4430 8151 247 686 -893 C

ATOM 716 O TYR A 119 29.895 12. .045 -4. ,634 1. .00 48. , 82 O

ANISOU 716 O TYR A 119 6004 4480 8065 474 623 -888 0

ATOM 717 CB TYR A 119 28.236 13. .630 -2. ,551 1. .00 46. , 80 c

ANISOU 717 CB TYR A 119 5702 4465 7617 471 565 -525 c

ATOM 718 CG TYR A 119 27.299 13. .849 -1. ,419 1. .00 47. , 28 c

ANISOU 718 CG TYR A 119 5802 4514 7649 491 669 -331 c

ATOM 719 CD1 TYR A 119 26.023 14. .343 -1. ,647 1. .00 46. ,76 c

ANISOU 719 CD1 TYR A 119 5600 4524 7641 245 669 -408 c

ATOM 720 CD2 TYR A 119 27.663 13. ,495 -0. ,121 1. .00 48. , 80 c

ANISOU 720 CD2 TYR A 119 6157 4648 7737 782 784 -64 c

ATOM 721 CE1 TYR A 119 25.138 14. .517 -0. ,595 1. .00 47. , 52 c

ANISOU 721 CE1 TYR A 119 5715 4629 7712 268 791 -237 c

ATOM 722 CE2 TYR A 119 26.790 13. .663 0. .933 1, .00 49. .58 c

ANISOU 722 CE2 TYR A 119 6299 4750 7788 804 906 119 c

ATOM 723 CZ TYR A 119 25.531 14. .171 0. .692 1, .00 48. .86 c

ANISOU 723 CZ TYR A 119 6067 4720 7779 535 918 24 c

ATOM 724 OH TYR A 119 24.678 14. .326 1. .747 1, .00 49. .90 0

ANISOU 724 OH TYR A 119 6226 4877 7857 566 1060 198 0

ATOM 725 N GLY A 120 27.827 12. .205 -5. ,560 1. .00 48. ,79 N

ANISOU 725 N GLY A 120 5831 4469 8237 -79 664 - 1137 N

ATOM 726 CA GLY A 120 28.283 12. .214 -6. ,945 1. .00 48. ,46 c ANISOU 726 CA GLY A 120 5688 4550 8175 -199 551 -1412 C

ATOM 727 C GLY A 120 28.091 10. .921 -7. .721 1. .00 51. .43 C

ANISOU 727 C GLY A 120 6130 4640 8771 -385 757 -1659 C

ATOM 728 O GLY A 120 27.232 10. .094 -7. .399 1. .00 53. .91 O

ANISOU 728 O GLY A 120 6522 4668 9292 -556 996 -1681 O

ATOM 729 N ASN A 121 28.917 10. .754 -8. .747 1. .00 51. .54 N

ANISOU 729 N ASN A 121 6117 4727 8741 -370 691 -1865 N

ATOM 730 CA ASN A 121 28.833 9. .626 -9. .660 1. .00 54. .51 C

ANISOU 730 CA ASN A 121 6546 4870 9295 -556 868 -2175 C

ATOM 731 C ASN A 121 29.215 8. .330 -9. .003 1. .00 57. .63 C

ANISOU 731 C ASN A 121 7230 4750 9917 -390 1189 -2079 C

ATOM 732 O ASN A 121 30.283 8. .218 -8. .437 1. .00 57. .52 O

ANISOU 732 O ASN A 121 7342 4671 9842 -14 1201 -1866 O

ATOM 733 CB ASN A 121 29.750 9. .850 -10. .854 1. .00 53. .90 C

ANISOU 733 CB ASN A 121 6376 5034 9071 -521 720 -2395 C

ATOM 734 CG ASN A 121 29.179 10. ,827 -11. .857 1. .00 52. .36 c

ANISOU 734 CG ASN A 121 5935 5283 8676 -745 481 -2561 c

ATOM 735 OD1 ASN A 121 29.288 10. .608 -13. .054 1. .00 53. .53 0

ANISOU 735 OD1 ASN A 121 6001 5572 8764 -884 450 -2859 0

ATOM 736 ND2 ASN A 121 28.571 11. .903 -11. .375 1. .00 50. .14 N

ANISOU 736 ND2 ASN A 121 5548 5229 8272 -747 325 -2364 N

ATOM 737 N PRO A 122 28.369 7. .324 -9. .142 1. .00 61. .00 N

ANISOU 737 N PRO A 122 7759 4817 10601 -669 1466 -2258 N

ATOM 738 CA PRO A 122 28.677 6. .042 -8. .562 1. .00 64. .75 C

ANISOU 738 CA PRO A 122 8573 4713 11317 -514 1838 -2152 C

ATOM 739 C PRO A 122 29.913 5. .485 -9. .267 1. .00 66. .03 C

ANISOU 739 C PRO A 122 8844 4770 11477 -270 1873 -2298 C

ATOM 740 O PRO A 122 30.808 4. .927 -8. .629 1. .00 67. .61 O

ANISOU 740 O PRO A 122 9279 4705 11706 151 2024 -2053 O

ATOM 741 CB PRO A 122 27.465 5. .208 -8. .962 1. .00 68. .37 C

ANISOU 741 CB PRO A 122 9055 4871 12052 -1006 2113 -2462 C

ATOM 742 CG PRO A 122 27.144 5. .718 -10. .337 1. .00 67. .25 C

ANISOU 742 CG PRO A 122 8593 5176 11783 -1323 1855 -2891 C

ATOM 743 CD PRO A 122 27.536 7. .182 -10. .346 1. .00 62. .32 C

ANISOU 743 CD PRO A 122 7735 5124 10818 -1109 1441 -2696 c

ATOM 744 N GLU A 123 29.939 5. .674 -10. .584 1. .00 65. .61 N

ANISOU 744 N GLU A 123 8599 4977 11355 -507 1726 -2691 N

ATOM 745 CA GLU A 123 30.948 5. .134 -11. .468 1. .00 67. .22 C

ANISOU 745 CA GLU A 123 8865 5120 11556 -360 1773 -2926 C

ATOM 746 C GLU A 123 32.404 5. .507 -11. .098 1. .00 65. .57 C

ANISOU 746 C GLU A 123 8660 5098 11156 159 1638 -2660 C

ATOM 747 O GLU A 123 33.309 4. .662 -11. .127 1. .00 68. .33 O

ANISOU 747 O GLU A 123 9195 5176 11589 476 1828 -2664 O

ATOM 748 CB GLU A 123 30.643 5. ,576 -12. .898 1. .00 66. .48 c

ANISOU 748 CB GLU A 123 8502 5435 11320 -705 1571 -3352 c

ATOM 749 N LEU A 124 32.629 6. .771 -10. .762 1. .00 61. .56 N

ANISOU 749 N LEU A 124 7934 5065 10392 245 1325 -2454 N

ATOM 750 CA LEU A 124 33.993 7. .242 -10. .542 1. .00 60. .25 C

ANISOU 750 CA LEU A 124 7687 5184 10022 642 1172 -2292 C

ATOM 751 C LEU A 124 34.549 6. .740 -9. .218 1. .00 61. .87 C

ANISOU 751 C LEU A 124 8085 5163 10261 1096 1309 -1926 C

ATOM 752 O LEU A 124 33.801 6. .538 -8. .272 1. .00 62. .42 O

ANISOU 752 O LEU A 124 8305 4986 10426 1086 1431 -1697 O

ATOM 753 CB LEU A 124 34.076 8. .761 -10. .627 1. .00 56. .13 c

ANISOU 753 CB LEU A 124 6893 5205 9230 543 835 -2227 c

ATOM 754 CG LEU A 124 33.532 9. .375 -11. .907 1. .00 54. .80 c

ANISOU 754 CG LEU A 124 6544 5314 8964 168 689 -2514 c

ATOM 755 CD1 LEU A 124 32.263 10. .112 -11. .508 1. .00 52. .89 c

ANISOU 755 CD1 LEU A 124 6236 5157 8705 -75 585 -2406 c

ATOM 756 CD2 LEU A 124 34.560 10. .310 -12. .535 1. .00 53. .01 c

ANISOU 756 CD2 LEU A 124 6127 5531 8484 239 490 -2553 c ATOM 757 N PRO A 125 35.869 6..514 -9..156 1..00 63..12 N

ANISOU 757 N PRO A 125 8224 5440 10317 1521 1300 - 1866 N

ATOM 758 CA PRO A 125 36.535 6. .012 -7. .959 1. .00 65. .38 C

ANISOU 758 CA PRO A 125 8663 5605 10572 2048 1409 - 1514 C

ATOM 759 C PRO A 125 36.498 6. .991 -6. .803 1. .00 62. .87 C

ANISOU 759 C PRO A 125 8218 5634 10035 2149 1192 - 1214 C

ATOM 760 O PRO A 125 36.247 8. .169 -7. .007 1. .00 59. .24 O

ANISOU 760 O PRO A 125 7525 5549 9434 1858 937 - 1297 O

ATOM 761 CB PRO A 125 37.979 5. .847 -8. .416 1. .00 66. .82 C

ANISOU 761 CB PRO A 125 8711 6049 10629 2422 1357 - 1609 C

ATOM 762 CG PRO A 125 37.901 5. .675 -9. .884 1. .00 66. .88 C

ANISOU 762 CG PRO A 125 8661 6021 10727 2098 1392 - 2024 C

ATOM 763 CD PRO A 125 36.797 6. .589 -10. .292 1. .00 63. .27 C

ANISOU 763 CD PRO A 125 8076 5721 10243 1549 1220 - 2149 C

ATOM 764 N GLU A 126 36.752 6. .506 -5. .591 1. .00 65. .23 N

ANISOU 764 N GLU A 126 8688 5805 10290 2581 1309 -865 N

ATOM 765 CA GLU A 126 36.690 7. .352 -4. .393 1. .00 63. .50 C

ANISOU 765 CA GLU A 126 8368 5921 9839 2699 1124 -593 C

ATOM 766 C GLU A 126 37.645 8. .517 -4. .542 1. .00 61. .01 C

ANISOU 766 C GLU A 126 7679 6256 9245 2720 781 -717 C

ATOM 767 O GLU A 126 37.262 9. .667 -4. .519 1. .00 57. .67 O

ANISOU 767 O GLU A 126 7083 6113 8716 2405 574 -786 O

ATOM 768 CB GLU A 126 37.039 6. .545 -3. .135 1. .00 67. .38 C

ANISOU 768 CB GLU A 126 9094 6247 10261 3264 1307 -194 C

ATOM 769 N ASP A 127 38.905 8. .185 -4. .733 1. .00 63. .16 N

ANISOU 769 N ASP A 127 7832 6751 9413 3092 754 -760 N

ATOM 770 CA ASP A 127 39.966 9. .207 -4. .928 1. .00 61. .68 C

ANISOU 770 CA ASP A 127 7256 7209 8971 3095 469 -920 C

ATOM 771 C ASP A 127 39.610 10. .258 -5. .945 1. .00 57. .92 C

ANISOU 771 C ASP A 127 6608 6889 8511 2538 320 - 1202 C

ATOM 772 O ASP A 127 40.148 11. .353 -5. .867 1. .00 56. .31 O

ANISOU 772 O ASP A 127 6137 7148 8110 2419 108 - 1287 O

ATOM 773 CB ASP A 127 41.260 8. .482 -5. .361 1. .00 65. .05 C

ANISOU 773 CB ASP A 127 7575 7787 9356 3517 527 - 1003 C

ATOM 774 CG ASP A 127 41.116 7. .715 -6. .671 1. .00 65. .88 c

ANISOU 774 CG ASP A 127 7818 7508 9707 3365 725 - 1245 c

ATOM 775 OD1 ASP A 127 40.606 6. .568 -6. .635 1. .00 68. .48 0

ANISOU 775 OD1 ASP A 127 8495 7263 10262 3505 1009 - 1150 0

ATOM 776 OD2 ASP A 127 41.519 8. .256 -7. .724 1. .00 64. .36 0

ANISOU 776 OD2 ASP A 127 7396 7583 9474 3096 620 - 1538 0

ATOM 777 N VAL A 128 38.754 9. .981 -6. .901 1. .00 56. .97 N

ANISOU 777 N VAL A 128 6626 6421 8598 2198 434 - 1356 N

ATOM 778 CA VAL A 128 38.383 10. .964 -7. .925 1. .00 53. .93 C

ANISOU 778 CA VAL A 128 6094 6210 8187 1726 298 - 1588 C

ATOM 779 C VAL A 128 37.192 11. .743 -7. .450 1. .00 51. .34 C

ANISOU 779 C VAL A 128 5822 5821 7864 1441 223 - 1480 C

ATOM 780 O VAL A 128 37.221 12. .964 -7. .502 1. .00 49. .04 O

ANISOU 780 O VAL A 128 5377 5828 7428 1239 48 - 1517 0

ATOM 781 CB VAL A 128 38.030 10. .283 -9. .287 1. .00 54. .72 c

ANISOU 781 CB VAL A 128 6279 6055 8456 1514 438 - 1849 c

ATOM 782 CGI VAL A 128 37.833 11. .333 -10. .390 1. .00 52. .21 c

ANISOU 782 CGI VAL A 128 5789 6016 8030 1115 287 - 2056 c

ATOM 783 CG2 VAL A 128 39.110 9. .294 -9. .647 1. .00 58. .00 c

ANISOU 783 CG2 VAL A 128 6702 6430 8905 1862 575 - 1943 c

ATOM 784 N LEU A 129 36.157 11. .059 -6. .973 1. .00 52. .10 N

ANISOU 784 N LEU A 129 6142 5525 8130 1424 381 - 1349 N

ATOM 785 CA LEU A 129 35.007 11. .754 -6. .414 1. .00 50. .07 C

ANISOU 785 CA LEU A 129 5915 5238 7870 1199 327 - 1235 C

ATOM 786 C LEU A 129 35.471 12. .656 -5. .241 1. .00 49. .11 C

ANISOU 786 C LEU A 129 5698 5437 7525 1377 168 - 1053 C

ATOM 787 O LEU A 129 34.901 13. .714 -5. .045 1. .00 46. .89 0 ANISOU 787 O LEU A 129 5355 5295 7166 1166 47 - 1046 O

ATOM 788 CB LEU A 129 33.851 10. .785 -6. .060 1. .00 51. .72 C

ANISOU 788 CB LEU A 129 6357 4987 8308 1133 566 - 1137 C

ATOM 789 N ASP A 130 36.535 12. .268 -4. .518 1. .00 51. .18 N

ANISOU 789 N ASP A 130 5932 5851 7663 1775 164 -937 N

ATOM 790 CA ASP A 130 37.129 13. .101 -3. .436 1. .00 50. .99 C

ANISOU 790 CA ASP A 130 5763 6230 7380 1944 -7 -837 C

ATOM 791 C ASP A 130 37.655 14. .438 -3. .917 1. .00 48. .93 C

ANISOU 791 C ASP A 130 5257 6357 6979 1676 -209 - 1055 C

ATOM 792 O ASP A 130 37.389 15. .462 -3. .305 1. .00 47. .60 O

ANISOU 792 O ASP A 130 5040 6355 6690 1544 -318 - 1041 O

ATOM 793 CB ASP A 130 38.316 12. .410 -2. .762 1. .00 54. .29 C

ANISOU 793 CB ASP A 130 6123 6856 7648 2451 -1 -721 C

ATOM 794 CG ASP A 130 37.922 11. .506 -1. .618 1. .00 56. .84 C

ANISOU 794 CG ASP A 130 6693 6939 7966 2821 164 -388 c

ATOM 795 OD1 ASP A 130 36.888 11. .762 -0. .947 1. .00 55. .82 0

ANISOU 795 OD1 ASP A 130 6704 6652 7854 2688 209 -241 0

ATOM 796 OD2 ASP A 130 38.686 10. .534 -1. .379 1. .00 60. .31 0

ANISOU 796 OD2 ASP A 130 7189 7358 8367 3282 265 -257 0

ATOM 797 N VAL A 131 38.425 14. ,408 -5. .001 1. .00 49. .14 N

ANISOU 797 N VAL A 131 5145 6505 7021 1600 -225 - 1259 N

ATOM 798 CA VAL A 131 39.185 15. .564 -5. .456 1. .00 48. .21 C

ANISOU 798 CA VAL A 131 4791 6766 6761 1375 -363 - 1458 C

ATOM 799 C VAL A 131 38.335 16. .562 -6. .216 1. .00 45. .56 C

ANISOU 799 C VAL A 131 4513 6320 6478 952 -385 - 1536 C

ATOM 800 O VAL A 131 38.581 17. .768 -6. .130 1. .00 44. .74 O

ANISOU 800 O VAL A 131 4313 6427 6259 745 -470 - 1613 0

ATOM 801 CB VAL A 131 40.353 15. .173 -6. .372 1. .00 49. .83 c

ANISOU 801 CB VAL A 131 4813 7176 6946 1453 -342 - 1642 c

ATOM 802 CGI VAL A 131 41.206 16. .396 -6. .671 1. .00 49. .54 c

ANISOU 802 CGI VAL A 131 4517 7553 6752 1199 -447 - 1837 c

ATOM 803 CG2 VAL A 131 41.191 14. ,075 -5. .738 1. .00 53. .07 c

ANISOU 803 CG2 VAL A 131 5172 7686 7306 1956 -300 - 1549 c

ATOM 804 N GLN A 132 37.377 16. .079 -7. .004 1. .00 44. .75 N

ANISOU 804 N GLN A 132 4561 5906 6537 824 -298 - 1534 N

ATOM 805 CA GLN A 132 36.500 17. .022 -7. .680 1. .00 42. .75 C

ANISOU 805 CA GLN A 132 4352 5601 6291 498 -332 - 1571 C

ATOM 806 C GLN A 132 35.679 17. .690 -6. .608 1. .00 41. .67 C

ANISOU 806 C GLN A 132 4298 5406 6128 482 -373 - 1418 C

ATOM 807 O GLN A 132 35.527 18. .902 -6. .612 1. .00 40. .60 0

ANISOU 807 O GLN A 132 4153 5365 5908 308 -433 - 1434 0

ATOM 808 CB GLN A 132 35.610 16. .327 -8. .712 1. .00 42. .71 c

ANISOU 808 CB GLN A 132 4437 5366 6424 377 -252 - 1636 c

ATOM 809 N LEU A 133 35.207 16. .900 -5. .644 1. .00 42. .39 N

ANISOU 809 N LEU A 133 4489 5332 6284 682 -312 - 1263 N

ATOM 810 CA LEU A 133 34.411 17. .452 -4. .550 1. .00 41. .70 C

ANISOU 810 CA LEU A 133 4478 5209 6155 694 -330 - 1116 C

ATOM 811 C LEU A 133 35.306 18. .367 -3. .755 1. .00 41. .97 C

ANISOU 811 C LEU A 133 4407 5548 5991 747 -440 - 1153 C

ATOM 812 O LEU A 133 34.888 19. .450 -3. .361 1. .00 41. .04 O

ANISOU 812 O LEU A 133 4314 5475 5806 614 -485 - 1158 O

ATOM 813 CB LEU A 133 33.823 16. .357 -3. .653 1. .00 43. .01 c

ANISOU 813 CB LEU A 133 4782 5150 6411 906 -202 -923 c

ATOM 814 N ALA A 134 36.553 17. .946 -3. .559 1. .00 43. .67 N

ANISOU 814 N ALA A 134 4488 5993 6110 939 -475 - 1210 N

ATOM 815 CA ALA A 134 37.482 18. .702 -2. .740 1. .00 44. .72 C

ANISOU 815 CA ALA A 134 4460 6500 6032 986 -587 - 1298 C

ATOM 816 C ALA A 134 37.698 20. .109 -3. .256 1. .00 43. .75 C

ANISOU 816 C ALA A 134 4268 6490 5865 629 -633 - 1491 C

ATOM 817 O ALA A 134 37.678 21. .042 -2. .476 1. .00 43. .96 O

ANISOU 817 O ALA A 134 4286 6637 5779 541 -679 - 1546 O ATOM 818 CB ALA A 134 38.800 17..981 -2..622 1..00 47.,19 C

ANISOU 818 CB ALA A 134 4580 7109 6240 1263 -624 - 1353 C

ATOM 819 N PHE A 135 37.893 20. .248 -4. .565 1. .00 43. ,11 N

ANISOU 819 N PHE A 135 4162 6351 5866 428 -593 - 1593 N

ATOM 820 CA PHE A 135 38.080 21. .551 -5. .198 1. .00 42. , 67 C

ANISOU 820 CA PHE A 135 4097 6338 5780 91 -578 - 1731 C

ATOM 821 C PHE A 135 36.871 22. .432 -5. .028 1. .00 41. , 23 C

ANISOU 821 C PHE A 135 4124 5906 5637 -41 -549 - 1631 C

ATOM 822 O PHE A 135 36.982 23. .586 -4. .615 1. .00 41. , 68 O

ANISOU 822 O PHE A 135 4213 5996 5625 -207 -538 - 1713 O

ATOM 823 CB PHE A 135 38.395 21. .378 -6. .685 1. .00 42. , 54 C

ANISOU 823 CB PHE A 135 4047 6299 5819 -45 -516 - 1804 C

ATOM 824 N LEU A 136 35.707 21. .879 -5. .352 1. .00 39. , 95 N

ANISOU 824 N LEU A 136 4095 5496 5587 33 -522 - 1476 N

ATOM 825 CA LEU A 136 34.500 22. .676 -5. .291 1. .00 38. , 91 C

ANISOU 825 CA LEU A 136 4126 5173 5486 -47 -495 - 1376 C

ATOM 826 C LEU A 136 34.409 23. .059 -3. .828 1. .00 39. , 37 C

ANISOU 826 C LEU A 136 4211 5282 5468 47 -519 - 1356 C

ATOM 827 O LEU A 136 34.309 24. .236 -3. .475 1. .00 39. , 65 O

ANISOU 827 O LEU A 136 4324 5296 5446 -74 -498 - 1411 O

ATOM 828 CB LEU A 136 33.262 21. .909 -5. .783 1. .00 38. , 05 C

ANISOU 828 CB LEU A 136 4080 4880 5497 15 -471 - 1253 C

ATOM 829 N ARG A 137 34.484 22. .043 -2. .981 1. .00 39. , 90 N

ANISOU 829 N ARG A 137 4231 5410 5520 276 -542 - 1278 N

ATOM 830 CA ARG A 137 34.311 22. .215 -1. .542 1. .00 40. , 67 C

ANISOU 830 CA ARG A 137 4354 5594 5503 420 -562 - 1228 C

ATOM 831 C ARG A 137 35.363 23. ,129 -0. .923 1. .00 42. , 14 C

ANISOU 831 C ARG A 137 4433 6066 5514 333 -627 - 1436 C

ATOM 832 O ARG A 137 35.055 23. .952 -0. .082 1. .00 42. , 63 O

ANISOU 832 O ARG A 137 4560 6152 5486 295 -625 - 1485 O

ATOM 833 CB ARG A 137 34.315 20. .848 -0. .833 1. .00 41. , 63 C

ANISOU 833 CB ARG A 137 4466 5734 5616 722 -545 - 1066 C

ATOM 834 CG ARG A 137 34.581 20. .924 0, .647 1, .00 43. .26 c

ANISOU 834 CG ARG A 137 4652 6168 5616 928 -586 - 1027 c

ATOM 835 CD ARG A 137 34.179 19. .639 1, .341 1, .00 44. .37 c

ANISOU 835 CD ARG A 137 4880 6214 5763 1238 -501 -771 c

ATOM 836 NE ARG A 137 35.306 18. .737 1, .537 1, .00 46. .48 N

ANISOU 836 NE ARG A 137 5044 6687 5928 1520 -537 -739 N

ATOM 837 CZ ARG A 137 36.578 19. .073 1, .322 1, .00 47. .47 C

ANISOU 837 CZ ARG A 137 4955 7155 5926 1513 -662 -944 C

ATOM 838 NH1 ARG A 137 36.892 20. .311 0, .921 1, .00 46. .59 N

ANISOU 838 NH1 ARG A 137 4741 7171 5788 1187 -737 - 1199 N

ATOM 839 NH2 ARG A 137 37.542 18. .161 1, .489 1, .00 49. .80 N

ANISOU 839 NH2 ARG A 137 5138 7659 6123 1837 -687 -893 N

ATOM 840 N LEU A 138 36.609 22. ,954 -1. .332 1. .00 43. ,26 N

ANISOU 840 N LEU A 138 4388 6446 5602 294 -675 - 1588 N

ATOM 841 CA LEU A 138 37.679 23. .850 -0. .903 1. .00 45. , 20 C

ANISOU 841 CA LEU A 138 4473 7009 5692 129 -724 - 1854 C

ATOM 842 C LEU A 138 37.536 25. .271 -1. .462 1. .00 45. ,01 C

ANISOU 842 C LEU A 138 4568 6805 5729 -246 -629 - 1999 C

ATOM 843 O LEU A 138 37.766 26. .251 -0. .750 1. .00 46. , 54 O

ANISOU 843 O LEU A 138 4767 7089 5828 -407 -615 - 2190 O

ATOM 844 CB LEU A 138 39.040 23. .272 -1. .290 1. .00 46. , 83 C

ANISOU 844 CB LEU A 138 4404 7558 5833 178 -782 - 1989 C

ATOM 845 N LEU A 139 37.165 25. .378 -2. .740 1. .00 43. , 62 N

ANISOU 845 N LEU A 139 4504 6371 5697 -375 -545 - 1914 N

ATOM 846 CA LEU A 139 37.274 26. ,649 -3. .476 1. .00 44. , 18 C

ANISOU 846 CA LEU A 139 4697 6279 5811 -703 -417 - 2018 C

ATOM 847 C LEU A 139 35.991 27. .438 -3. .808 1. .00 43. , 14 C

ANISOU 847 C LEU A 139 4866 5760 5764 -729 -314 - 1851 C

ATOM 848 O LEU A 139 36.082 28. .453 -4. .489 1. .00 44. ,06 O ANISOU 848 O LEU A 139 5128 5702 5910 -952 -176 - 1886 O

ATOM 849 CB LEU A 139 38.083 26. .430 -4. ,757 1. .00 44. , 50 C

ANISOU 849 CB LEU A 139 4626 6400 5883 -847 -369 - 2072 C

ATOM 850 CG LEU A 139 39.609 26. .465 -4. ,599 1. .00 46. , 91 C

ANISOU 850 CG LEU A 139 4635 7095 6091 -999 -386 - 2348 C

ATOM 851 CD1 LEU A 139 40.053 25. .874 -3. ,294 1. .00 47. , 98 C

ANISOU 851 CD1 LEU A 139 4558 7575 6097 -773 -540 - 2436 C

ATOM 852 CD2 LEU A 139 40.337 25. .743 -5. ,715 1. .00 47. , 04 C

ANISOU 852 CD2 LEU A 139 4485 7261 6127 -995 -371 - 2362 C

ATOM 853 N SER A 140 34.819 27. .010 -3. ,334 1. .00 41. , 73 N

ANISOU 853 N SER A 140 4778 5458 5618 -494 -357 - 1663 N

ATOM 854 CA SER A 140 33.571 27. .723 -3. ,663 1. .00 41. , 15 C

ANISOU 854 CA SER A 140 4938 5089 5608 -462 -271 - 1504 C

ATOM 855 C SER A 140 33.371 28. .928 -2. ,744 1. .00 42. , 60 C

ANISOU 855 C SER A 140 5287 5149 5752 -528 -182 - 1604 C

ATOM 856 O SER A 140 33.950 28. .960 -1. ,653 1. .00 43. , 68 O

ANISOU 856 O SER A 140 5331 5468 5797 -554 -226 - 1782 O

ATOM 857 CB SER A 140 32.377 26. .785 -3. ,560 1. .00 39. , 57 C

ANISOU 857 CB SER A 140 4723 4846 5464 -219 -333 - 1300 C

ATOM 858 OG SER A 140 32.483 25. .751 -4. ,506 1. .00 38. , 70 O

ANISOU 858 OG SER A 140 4500 4796 5408 -195 -381 - 1248 0

ATOM 859 N SER A 141 32.568 29. .912 -3. ,163 1. .00 43. , 10 N

ANISOU 859 N SER A 141 5592 4921 5861 -529 -53 - 1501 N

ATOM 860 CA SER A 141 32.262 31. .073 -2. ,296 1. .00 44. ,86 C

ANISOU 860 CA SER A 141 6020 4959 6066 -560 69 - 1601 C

ATOM 861 C SER A 141 31.545 30. .699 -0. ,993 1. .00 44. , 39 C

ANISOU 861 C SER A 141 5915 5000 5951 -342 -5 - 1587 C

ATOM 862 O SER A 141 31.887 31. .201 0. .076 1, .00 45. .99 O

ANISOU 862 O SER A 141 6143 5260 6071 -409 22 - 1797 O

ATOM 863 CB SER A 141 31.462 32. .138 -3. ,045 1. .00 45. , 91 C

ANISOU 863 CB SER A 141 6451 4734 6258 -513 245 - 1440 c

ATOM 864 N ARG A 142 30.556 29. .819 -1. ,096 1. .00 42. , 60 N

ANISOU 864 N ARG A 142 5614 4813 5759 -103 -82 - 1360 N

ATOM 865 CA ARG A 142 29.808 29. .295 0. .047 1, .00 42. .26 C

ANISOU 865 CA ARG A 142 5516 4872 5667 106 -123 - 1298 C

ATOM 866 C ARG A 142 29.159 27. .962 -0. ,361 1. .00 40. , 50 C

ANISOU 866 C ARG A 142 5140 4732 5515 249 -201 - 1090 C

ATOM 867 O ARG A 142 29.048 27. .656 -1. ,550 1. .00 39. , 66 O

ANISOU 867 O ARG A 142 4997 4584 5490 209 -223 - 1008 O

ATOM 868 CB ARG A 142 28.733 30. .291 0. .487 1, .00 43. .35 C

ANISOU 868 CB ARG A 142 5850 4812 5809 232 2 - 1257 c

ATOM 869 N ALA A 143 28.735 27. .167 0. .612 1, .00 40. .37 N

ANISOU 869 N ALA A 143 5046 4832 5460 401 -222 - 1017 N

ATOM 870 CA ALA A 143 27.972 25. .965 0. .312 1, .00 39. .40 C

ANISOU 870 CA ALA A 143 4813 4721 5434 496 -232 -839 C

ATOM 871 C ALA A 143 26.757 25. .906 1. .203 1, .00 39. .94 C

ANISOU 871 C ALA A 143 4895 4787 5492 652 -150 -724 C

ATOM 872 O ALA A 143 26.726 26. .521 2. .262 1, .00 40. .98 O

ANISOU 872 O ALA A 143 5107 4958 5505 726 -107 -780 O

ATOM 873 CB ALA A 143 28.808 24. .731 0. .515 1, .00 39. .25 c

ANISOU 873 CB ALA A 143 4685 4824 5402 516 -288 -830 c

ATOM 874 N SER A 144 25.759 25. ,146 0. ,777 1. .00 39. , 60 N

ANISOU 874 N SER A 144 4756 4724 5566 683 -115 -591 N

ATOM 875 CA SER A 144 24.549 24. .961 1. .565 1, .00 40. .45 C

ANISOU 875 CA SER A 144 4828 4861 5679 803 -9 -481 C

ATOM 876 C SER A 144 24.002 23. .575 1. .280 1, .00 40. .50 C

ANISOU 876 C SER A 144 4699 4867 5822 750 42 -379 C

ATOM 877 O SER A 144 24.183 23. .043 0. .199 1, .00 39. .89 O

ANISOU 877 O SER A 144 4550 4757 5850 631 -12 -415 O

ATOM 878 CB SER A 144 23.500 26. .002 1. .191 1, .00 41. .00 c

ANISOU 878 CB SER A 144 4907 4905 5764 880 27 -469 c ATOM 879 OG SER A 144 22.693 25.,536 0..114 1..00 40..90 O

ANISOU 879 OG SER A 144 4735 4938 5867 838 6 ^■415 O

ATOM 880 N GLN A 145 23.325 22. ,993 2. .252 1. .00 41. .63 N

ANISOU 880 N GLN A 145 4821 5035 5962 821 175 ^■268 N

ATOM 881 CA GLN A 145 22.704 21. ,690 2. .053 1. .00 42. .41 C

ANISOU 881 CA GLN A 145 4816 5081 6219 724 290 ^■184 C

ATOM 882 C GLN A 145 21.434 21. ,550 2. .877 1. .00 44. .09 C

ANISOU 882 C GLN A 145 4957 5352 6444 766 471 -81 C

ATOM 883 O GLN A 145 21.373 22. ,001 4. .022 1. .00 44. .81 O

ANISOU 883 O GLN A 145 5136 5508 6382 921 535 -17 O

ATOM 884 CB GLN A 145 23.673 20. ,576 2. .428 1. .00 42. .77 C

ANISOU 884 CB GLN A 145 4956 5028 6265 744 331 ^■113 C

ATOM 885 CG GLN A 145 23.183 19. ,194 2. .031 1. .00 43. .97 c

ANISOU 885 CG GLN A 145 5058 5024 6624 603 486 -59 c

ATOM 886 CD GLN A 145 24.218 18. ,126 2. .277 1. .00 44. .70 c

ANISOU 886 CD GLN A 145 5288 4971 6725 683 541 27 c

ATOM 887 OE1 GLN A 145 25.225 18. ,360 2. .945 1. .00 44. .59 0

ANISOU 887 OE1 GLN A 145 5370 5046 6525 880 462 75 0

ATOM 888 NE2 GLN A 145 23.975 16. ,942 1. .742 1. .00 45. .95 N

ANISOU 888 NE2 GLN A 145 5447 4919 7091 541 687 29 N

ATOM 889 N GLN A 146 20.435 20. ,902 2. .296 1. ,00 45. ,09 N

ANISOU 889 N GLN A 146 4905 5486 6740 610 561 -91 N

ATOM 890 CA GLN A 146 19.168 20. ,696 2. .976 1. .00 47. .14 C

ANISOU 890 CA GLN A 146 5040 5836 7035 600 760 -16 C

ATOM 891 C GLN A 146 18.918 19. ,227 3. .227 1. .00 49. .02 C

ANISOU 891 C GLN A 146 5273 5920 7432 421 989 67 C

ATOM 892 O GLN A 146 19.265 18. ,399 2. .398 1. .00 48. .97 O

ANISOU 892 O GLN A 146 5258 5772 7577 245 979 -8 O

ATOM 893 CB GLN A 146 18.034 21. ,229 2. .126 1. .00 47. .75 C

ANISOU 893 CB GLN A 146 4853 6117 7174 549 707 ^■127 C

ATOM 894 CG GLN A 146 17.693 22. ,677 2. .381 1. .00 47. .56 C

ANISOU 894 CG GLN A 146 4840 6235 6995 798 631 ^■130 C

ATOM 895 CD GLN A 146 16.262 22. ,966 2. .027 1. .00 49. .52 C

ANISOU 895 CD GLN A 146 4787 6746 7281 825 674 ^■170 c

ATOM 896 OE1 GLN A 146 15.393 22. ,098 2. .149 1. .00 51. .49 0

ANISOU 896 OE1 GLN A 146 4815 7102 7648 650 831 ^■180 0

ATOM 897 NE2 GLN A 146 16.001 24. ,189 1. .579 1. .00 49. .49 N

ANISOU 897 NE2 GLN A 146 4769 6857 7177 1049 554 ^■195 N

ATOM 898 N ILE A 147 18.297 18. ,908 4. .358 1. .00 51. .08 N

ANISOU 898 N ILE A 147 5557 6190 7659 462 1228 218 N

ATOM 899 CA ILE A 147 18.029 17. ,515 4. .711 1. .00 53. .60 C

ANISOU 899 CA ILE A 147 5930 6301 8135 290 1522 338 C

ATOM 900 C ILE A 147 16.714 17. ,379 5. .453 1. .00 56. .42 C

ANISOU 900 C ILE A 147 6140 6775 8521 208 1799 413 C

ATOM 901 O ILE A 147 16.436 18. ,153 6. .370 1. .00 56. .61 O

ANISOU 901 O ILE A 147 6180 6979 8349 422 1820 499 O

ATOM 902 CB ILE A 147 19.148 16. ,910 5. .579 1. .00 53. .95 C

ANISOU 902 CB ILE A 147 6294 6146 8059 486 1601 556 C

ATOM 903 CGI ILE A 147 19.087 15. ,394 5. .513 1. .00 56. .59 C

ANISOU 903 CGI ILE A 147 6741 6149 8610 303 1894 661 C

ATOM 904 CG2 ILE A 147 19.067 17. ,408 7. .017 1. .00 54. .93 C

ANISOU 904 CG2 ILE A 147 6531 6423 7917 747 1691 740 c

ATOM 905 CD1 ILE A 147 20.351 14. ,717 5. .967 1. .00 57. .01 c

ANISOU 905 CD1 ILE A 147 7101 5991 8569 540 1922 857 c

ATOM 906 N THR A 148 15.920 16. ,385 5. .053 1. ,00 58. , 97 N

ANISOU 906 N THR A 148 6313 7002 9091 -123 2030 352 N

ATOM 907 CA THR A 148 14.616 16. ,145 5. .652 1. .00 62. .27 C

ANISOU 907 CA THR A 148 6535 7549 9574 -280 2333 389 C

ATOM 908 C THR A 148 14.652 14. ,926 6. .553 1. .00 65. .44 C

ANISOU 908 C THR A 148 7186 7625 10054 -379 2742 635 C

ATOM 909 O THR A 148 15.250 13. ,915 6. .206 1. .00 66. .18 O ANISOU 909 O THR A 148 7477 7361 10306 -510 2847 665 O

ATOM 910 CB THR A 148 13.505 15. .924 4. .601 1. .00 64. .03 C

ANISOU 910 CB THR A 148 6342 7969 10017 -641 2349 103 C

ATOM 911 OG1 THR A 148 13.452 17. .026 3. .686 1. .00 61. .63 O

ANISOU 911 OG1 THR A 148 5822 7978 9615 -500 1978 -85 O

ATOM 912 CG2 THR A 148 12.155 15. .794 5. .283 1. .00 67. .73 C

ANISOU 912 CG2 THR A 148 6551 8651 10531 -795 2661 122 C

ATOM 913 N TYR A 149 13.987 15. .042 7. .706 1. .00 67. .71 N

ANISOU 913 N TYR A 149 7475 8032 10221 -296 2997 819 N

ATOM 914 CA TYR A 149 13.753 13. .928 8. .631 1. .00 71. .74 C

ANISOU 914 CA TYR A 149 8202 8265 10791 -404 3468 1090 C

ATOM 915 C TYR A 149 12.267 13. .602 8. .664 1. .00 75. .57 C

ANISOU 915 C TYR A 149 8353 8893 11469 -786 3800 983 C

ATOM 916 O TYR A 149 11.489 14. .360 9. .169 1. .00 76. .11 O

ANISOU 916 O TYR A 149 8196 9325 11399 -690 3815 970 O

ATOM 917 CB TYR A 149 14.251 14. .265 10. .039 1. ,00 71. , 98 C

ANISOU 917 CB TYR A 149 8524 8355 10472 15 3533 1417 C

ATOM 918 N HIS A 150 11.878 12. .500 8. .039 1. .00 78. .46 N

ANISOU 918 N HIS A 150 8656 8992 12165 -1240 4057 856 N

ATOM 919 CA HIS A 150 10.499 12. .004 8. .122 1. .00 83. .14 C

ANISOU 919 CA HIS A 150 8925 9697 12967 -1687 4446 735 C

ATOM 920 C HIS A 150 10.345 11. .386 9. .469 1. .00 86. .88 C

ANISOU 920 C HIS A 150 9704 9934 13372 -1644 4939 1124 C

ATOM 921 O HIS A 150 11.264 10. .745 9. .954 1. .00 87. .25 O

ANISOU 921 O HIS A 150 10232 9554 13367 -1454 5081 1431 O

ATOM 922 CB HIS A 150 10.208 10. .998 7. .014 1. .00 85. .57 C

ANISOU 922 CB HIS A 150 9087 9773 13651 -2232 4580 422 C

ATOM 923 CG HIS A 150 10.241 11. .609 5. .639 1. .00 82. .51 c

ANISOU 923 CG HIS A 150 8353 9708 13290 -2280 4101 26 c

ATOM 924 ND1 HIS A 150 9.326 12. .495 5. .238 1. .00 82. .29 N

ANISOU 924 ND1 HIS A 150 7817 10266 13185 -2290 3884 -214 N

ATOM 925 CD2 HIS A 150 11.142 11. .466 4. .577 1. .00 79. .79 C

ANISOU 925 CD2 HIS A 150 8123 9188 13006 -2268 3802 -141 C

ATOM 926 CE1 HIS A 150 9.604 12. .900 3. .983 1. .00 79. .72 C

ANISOU 926 CE1 HIS A 150 7302 10132 12855 -2279 3470 -499 C

ATOM 927 NE2 HIS A 150 10.716 12. .267 3. .578 1. .00 78. .11 N

ANISOU 927 NE2 HIS A 150 7478 9463 12739 -2287 3425 -463 N

ATOM 928 N CYS A 151 9.196 11. .610 10. .096 1. .00 89. .93 N

ANISOU 928 N CYS A 151 9808 10635 13726 -1773 5203 1131 N

ATOM 929 CA CYS A 151 8.936 11. .081 11. .413 1. .00 94. .00 C

ANISOU 929 CA CYS A 151 10590 10983 14142 -1737 5710 1514 C

ATOM 930 C CYS A 151 7.516 10. .534 11. .646 1. .00 99. .83 C

ANISOU 930 C CYS A 151 10997 11833 15103 -2256 6228 1420 C

ATOM 931 O CYS A 151 6.536 11. .037 11. .082 1. , 00100. , 30 O

ANISOU 931 O CYS A 151 10488 12365 15255 -2490 6111 1060 O

ATOM 932 CB CYS A 151 9.261 12. .088 12. .458 1. .00 91. .84 C

ANISOU 932 CB CYS A 151 10447 11015 13433 -1175 5538 1755 C

ATOM 933 SG CYS A 151 7.937 13. .285 12. .587 1. .00 92. .13 S

ANISOU 933 SG CYS A 151 9892 11754 13361 -1163 5446 1501 S

ATOM 934 N LYS A 152 7.448 9. .490 12. .496 1. .00104. .72 N

ANISOU 934 N LYS A 152 11982 12019 15790 -2411 6819 1766 N

ATOM 935 CA LYS A 152 6.244 9. .078 13. .214 1. .00110. .73 C

ANISOU 935 CA LYS A 152 12554 12883 16635 -2774 7402 1839 C

ATOM 936 C LYS A 152 6.635 8. .933 14. .732 1. .00112. .74 C

ANISOU 936 C LYS A 152 13323 12973 16542 -2349 7742 2426 C

ATOM 937 O LYS A 152 7.600 8. .238 15. .076 1. .00113. .26 O

ANISOU 937 O LYS A 152 13966 12520 16549 -2127 7879 2789 O

ATOM 938 N ASN A 153 5.884 9. .586 15. .617 1. .00114. .25 N

ANISOU 938 N ASN A 153 13292 13639 16477 -2206 7875 2513 N

ATOM 939 CA ASN A 153 6.130 9. .488 17. .061 1. .00116. .78 C

ANISOU 939 CA ASN A 153 14044 13905 16421 -1817 8208 3037 C ATOM 940 C ASN A 153 7.591 9..748 17..407 1..00112..74 C

ANISOU 940 C ASN A 153 14039 13240 15558 -1174 7832 3324 C

ATOM 941 O ASN A 153 8.194 8. .993 18. .184 1. .00115. .65 O

ANISOU 941 O ASN A 153 14945 13232 15767 -954 8157 3796 O

ATOM 942 N SER A 154 8.150 10. .810 16. .820 1. .00106. .56 N

ANISOU 942 N SER A 154 13073 12765 14649 -873 7166 3039 N

ATOM 943 CA SER A 154 9.578 11. .102 16. .943 1. .00102. .55 C

ANISOU 943 CA SER A 154 12952 12159 13855 -340 6751 3200 C

ATOM 944 C SER A 154 9.949 12. .592 16. .777 1. .00 96. .95 C

ANISOU 944 C SER A 154 12017 11944 12875 40 6124 2924 C

ATOM 945 O SER A 154 9.815 13. .148 15. .702 1. .00 93. .47 O

ANISOU 945 O SER A 154 11243 11629 12641 -113 5757 2535 O

ATOM 946 CB SER A 154 10.352 10. .237 15. .949 1. .00101. .46 C

ANISOU 946 CB SER A 154 13024 11486 14039 -516 6670 3151 C

ATOM 947 OG SER A 154 11.729 10. .528 15. .981 1. .00 97. .75 0

ANISOU 947 OG SER A 154 12856 10976 13308 -20 6254 3266 0

ATOM 948 N ILE A 155 10.441 13. .206 17. .851 1. ,00 96. , 62 N

ANISOU 948 N ILE A 155 12187 12165 12360 535 6028 3130 N

ATOM 949 CA ILE A 155 10.819 14. .626 17. .888 1. .00 92. .30 C

ANISOU 949 CA ILE A 155 11498 12042 11529 896 5515 2878 C

ATOM 950 C ILE A 155 12.136 14. .885 17. .161 1. .00 87. .58 C

ANISOU 950 C ILE A 155 11051 11301 10925 1083 5008 2752 C

ATOM 951 O ILE A 155 13.158 14. .305 17. .494 1. .00 88. .01 O

ANISOU 951 O ILE A 155 11470 11148 10824 1311 5001 3013 O

ATOM 952 CB ILE A 155 10.900 15. .142 19. .345 1. .00 94. .38 C

ANISOU 952 CB ILE A 155 11943 12653 11267 1325 5622 3098 c

ATOM 953 CGI ILE A 155 9.522 15. .089 19. .995 1. .00 98. .81 c

ANISOU 953 CGI ILE A 155 12281 13436 11824 1144 6097 3161 c

ATOM 954 CG2 ILE A 155 11.476 16. .553 19. .418 1. .00 90. .40 c

ANISOU 954 CG2 ILE A 155 11373 12505 10468 1687 5111 2815 c

ATOM 955 CD1 ILE A 155 9.575 15. .219 21. .501 1. .00102. .29 c

ANISOU 955 CD1 ILE A 155 12973 14147 11745 1523 6344 3471 c

ATOM 956 N ALA A 156 12.045 15. .681 16. .106 1. .00 83. .64 N

ANISOU 956 N ALA A 156 10250 10914 10617 971 4623 2363 N

ATOM 957 CA ALA A 156 13.193 16. .136 15. .332 1. .00 79. .08 C

ANISOU 957 CA ALA A 156 9748 10260 10037 1115 4135 2186 C

ATOM 958 C ALA A 156 14.001 17. .212 16. .047 1. .00 77. .21 C

ANISOU 958 C ALA A 156 9649 10316 9373 1553 3827 2143 C

ATOM 959 O ALA A 156 15.205 17. .051 16. .278 1. ,00 76. , 33 0

ANISOU 959 O ALA A 156 9800 10141 9061 1791 3651 2252 0

ATOM 960 N TYR A 157 13.335 18. .302 16. .419 1. .00 77. .13 N

ANISOU 960 N TYR A 157 9448 10644 9214 1661 3779 1963 N

ATOM 961 CA TYR A 157 14.027 19. .517 16. .835 1. .00 75. .15 C

ANISOU 961 CA TYR A 157 9279 10641 8634 1991 3454 1783 C

ATOM 962 C TYR A 157 13.396 20. .107 18. .072 1. .00 78. .05 C

ANISOU 962 C TYR A 157 9642 11349 8664 2212 3657 1814 C

ATOM 963 O TYR A 157 13.966 20. .083 19. .163 1. .00 79. .91 O

ANISOU 963 O TYR A 157 10114 11750 8499 2485 3704 1965 O

ATOM 964 CB TYR A 157 13.929 20. .530 15. .706 1. .00 71. .59 C

ANISOU 964 CB TYR A 157 8606 10197 8396 1909 3119 1423 c

ATOM 965 CG TYR A 157 14.497 21. .890 15. .997 1. .00 69. .95 c

ANISOU 965 CG TYR A 157 8476 10174 7929 2175 2834 1179 c

ATOM 966 CD1 TYR A 157 15.868 22. .115 15. .951 1. .00 67. .96 c

ANISOU 966 CD1 TYR A 157 8427 9873 7523 2289 2541 1105 c

ATOM 967 CD2 TYR A 157 13.663 22. .960 16. .284 1. .00 70. .82 c

ANISOU 967 CD2 TYR A 157 8447 10500 7963 2299 2875 995 c

ATOM 968 CE1 TYR A 157 16.394 23. .376 16. .187 1. .00 66. .99 c

ANISOU 968 CE1 TYR A 157 8371 9892 7189 2460 2310 828 c

ATOM 969 CE2 TYR A 157 14.175 24. .222 16. .523 1. .00 69. .84 c

ANISOU 969 CE2 TYR A 157 8432 10472 7633 2513 2657 738 c

ATOM 970 CZ TYR A 157 15.540 24. .422 16. .479 1. .00 67. .99 c ANISOU 970 CZ TYR A 157 8406 10166 7261 2562 2383 644 C

ATOM 971 OH TYR A 157 16.040 25. .673 16. .723 1. .00 67. .61 O

ANISOU 971 OH TYR A 157 8467 10192 7030 2708 2205 346 O

ATOM 972 N MET A 158 12.196 20. .643 17. .879 1. .00 78. .77 N

ANISOU 972 N MET A 158 9440 11588 8900 2114 3775 1657 N

ATOM 973 CA MET A 158 11.417 21. .218 18. .976 1. ,00 81. , 87 C

ANISOU 973 CA MET A 158 9779 12317 9010 2311 4009 1656 C

ATOM 974 C MET A 158 10.436 20. .225 19. .577 1. .00 86. .27 C

ANISOU 974 C MET A 158 10261 12916 9603 2144 4516 1946 C

ATOM 975 O MET A 158 9.602 19. .638 18. .873 1. .00 87. .08 O

ANISOU 975 O MET A 158 10103 12910 10074 1804 4697 1947 O

ATOM 976 CB MET A 158 10.655 22. .465 18. .529 1. .00 80. .88 C

ANISOU 976 CB MET A 158 9379 12371 8981 2379 3877 1321 C

ATOM 977 N ASP A 159 10.556 20. .044 20. .888 1. .00 89. .54 N

ANISOU 977 N ASP A 159 10900 13510 9612 2374 4757 2178 N

ATOM 978 CA ASP A 159 9.606 19. .252 21. .647 1. .00 94. .45 C

ANISOU 978 CA ASP A 159 11483 14211 10192 2257 5294 2469 C

ATOM 979 C ASP A 159 8.462 20. .163 22. .045 1. .00 96. .30 C

ANISOU 979 C ASP A 159 11414 14831 10343 2337 5436 2261 C

ATOM 980 O ASP A 159 8.681 21. .180 22. .709 1. .00 96. .20 O

ANISOU 980 O ASP A 159 11479 15094 9977 2680 5290 2094 O

ATOM 981 CB ASP A 159 10.268 18. .643 22. .888 1. .00 97. .66 C

ANISOU 981 CB ASP A 159 12291 14668 10147 2524 5503 2855 C

ATOM 982 CG ASP A 159 9.305 17. .797 23. .713 1. .00103. .33 c

ANISOU 982 CG ASP A 159 13021 15436 10803 2402 6120 3207 c

ATOM 983 OD1 ASP A 159 8.109 17. .706 23. .360 1. .00104. .84 0

ANISOU 983 OD1 ASP A 159 12871 15657 11308 2080 6387 3113 0

ATOM 984 OD2 ASP A 159 9.751 17. .213 24. .720 1. .00106. .70 0

ANISOU 984 OD2 ASP A 159 13792 15899 10851 2634 6351 3587 0

ATOM 985 N GLN A 160 7.249 19. .801 21. .629 1. .00 98. .36 N

ANISOU 985 N GLN A 160 11314 15129 10930 2018 5727 2238 N

ATOM 986 CA GLN A 160 6.078 20. .633 21. .894 1. .00100. .47 C

ANISOU 986 CA GLN A 160 11221 15797 11155 2104 5870 2028 C

ATOM 987 C GLN A 160 5.930 20. .877 23. .395 1. .00104. .30 C

ANISOU 987 C GLN A 160 11888 16597 11146 2413 6164 2182 C

ATOM 988 O GLN A 160 5.856 22. .027 23. .838 1. .00104. .14 O

ANISOU 988 O GLN A 160 11846 16860 10864 2753 6025 1943 0

ATOM 989 CB GLN A 160 4.808 19. .999 21. .319 1. .00103. .20 c

ANISOU 989 CB GLN A 160 11113 16201 11896 1676 6193 2008 c

ATOM 990 N ALA A 161 5.940 19. ,780 24. ,158 1. , 00108. , 02 N

ANISOU 990 N ALA A 161 12576 16990 11478 2307 6580 2585 N

ATOM 991 CA ALA A 161 5.663 19. .766 25. .609 1. .00112. .82 C

ANISOU 991 CA ALA A 161 13346 17918 11601 2553 6966 2812 C

ATOM 992 C ALA A 161 6.699 20. .490 26. .483 1. .00112. .00 C

ANISOU 992 C ALA A 161 13602 18012 10942 3040 6689 2771 C

ATOM 993 O ALA A 161 6.340 21. .102 27. .498 1. .00115. .00 O

ANISOU 993 O ALA A 161 13991 18793 10912 3320 6851 2714 O

ATOM 994 CB ALA A 161 5.473 18. .333 26. .091 1. .00117. .31 c

ANISOU 994 CB ALA A 161 14106 18282 12185 2306 7502 3303 c

ATOM 995 N SER A 162 7.972 20. .412 26. .094 1. .00108. .38 N

ANISOU 995 N SER A 162 13413 17309 10459 3129 6284 2770 N

ATOM 996 CA SER A 162 9.050 21. .123 26. .792 1. .00107. .59 C

ANISOU 996 CA SER A 162 13595 17429 9856 3538 5961 2649 C

ATOM 997 C SER A 162 9.282 22. .514 26. .201 1. .00103. .61 C

ANISOU 997 C SER A 162 12952 16973 9442 3638 5505 2118 C

ATOM 998 O SER A 162 9.710 23. .441 26. .899 1. .00104. .18 O

ANISOU 998 O SER A 162 13148 17326 9109 3941 5341 1871 O

ATOM 999 CB SER A 162 10.349 20. ,298 26. ,800 1. ,00106. , 73 c

ANISOU 999 CB SER A 162 13834 17105 9613 3619 5790 2934 c

ATOM 1000 OG SER A 162 10.978 20. .254 25. .526 1. .00101. .76 0

ANISOU 1000 OG SER A 162 13154 16102 9407 3421 5408 2773 0 ATOM 1001 N GLY A 163 8.937 22..662 24..926 1..00100..19 N

ANISOU 1001 N GLY A 163 12265 16271 9533 3377 5339 1937 N

ATOM 1002 CA GLY A 163 9.277 23. .858 24. .177 1. .00 96. .34 C

ANISOU 1002 CA GLY A 163 11704 15715 9184 3456 4912 1504 C

ATOM 1003 C GLY A 163 10.788 23. .942 24. .107 1. .00 93. .62 C

ANISOU 1003 C GLY A 163 11660 15244 8667 3553 4522 1446 C

ATOM 1004 O GLY A 163 11.366 25. .027 24. .173 1. .00 92. .27 O

ANISOU 1004 O GLY A 163 11578 15145 8334 3725 4235 1097 O

ATOM 1005 N ASN A 164 11.423 22. .780 23. .979 1. .00 93. .31 N

ANISOU 1005 N ASN A 164 11773 15012 8668 3437 4539 1779 N

ATOM 1006 CA ASN A 164 12.872 22. .681 24. .033 1. .00 91. .63 C

ANISOU 1006 CA ASN A 164 11816 14759 8241 3565 4209 1779 C

ATOM 1007 C ASN A 164 13.461 21. .924 22. .856 1. .00 88. .23 C

ANISOU 1007 C ASN A 164 11389 13919 8217 3324 4023 1887 C

ATOM 1008 O ASN A 164 12.778 21. .136 22. .196 1. .00 88. .13 O

ANISOU 1008 O ASN A 164 11244 13647 8596 3046 4231 2062 O

ATOM 1009 CB ASN A 164 13.310 22. .016 25. .342 1. .00 95. .86 C

ANISOU 1009 CB ASN A 164 12608 15572 8242 3831 4409 2116 C

ATOM 1010 N VAL A 165 14.745 22. .156 22. .618 1. .00 85. .89 N

ANISOU 1010 N VAL A 165 11231 13594 7809 3417 3644 1752 N

ATOM 1011 CA VAL A 165 15.465 21. .494 21. .541 1. .00 82. .79 C

ANISOU 1011 CA VAL A 165 10859 12850 7748 3235 3444 1825 C

ATOM 1012 C VAL A 165 16.371 20. .389 22. .052 1. .00 84. .79 C

ANISOU 1012 C VAL A 165 11358 13099 7758 3407 3495 2198 C

ATOM 1013 O VAL A 165 17.192 19. ,859 21. ,315 1. ,00 82. ,71 O

ANISOU 1013 O VAL A 165 11149 12596 7679 3342 3307 2250 O

ATOM 1014 CB VAL A 165 16.334 22. .501 20. .779 1. .00 78. .90 C

ANISOU 1014 CB VAL A 165 10328 12313 7339 3209 2990 1416 C

ATOM 1015 CGI VAL A 165 15.483 23. .656 20. .281 1. .00 77. .47 c

ANISOU 1015 CGI VAL A 165 9957 12106 7371 3116 2953 1080 c

ATOM 1016 CG2 VAL A 165 17.449 23. .001 21. .676 1. .00 80. .20 c

ANISOU 1016 CG2 VAL A 165 10652 12820 7000 3482 2774 1271 c

ATOM 1017 N LYS A 166 16.228 20. .043 23. .321 1. .00 89. .21 N

ANISOU 1017 N LYS A 166 12073 13943 7879 3665 3761 2470 N

ATOM 1018 CA LYS A 166 17.130 19. .103 23. .938 1. .00 91. .92 C

ANISOU 1018 CA LYS A 166 12675 14359 7892 3943 3803 2848 C

ATOM 1019 C LYS A 166 17.108 17. .831 23. .128 1. .00 91. .50 C

ANISOU 1019 C LYS A 166 12703 13792 8270 3739 3986 3175 C

ATOM 1020 O LYS A 166 18.137 17. .212 22. .899 1. .00 91. .27 O

ANISOU 1020 O LYS A 166 12825 13649 8205 3884 3836 3331 O

ATOM 1021 CB LYS A 166 16.718 18. .828 25. .379 1. .00 97. .43 c

ANISOU 1021 CB LYS A 166 13533 15410 8074 4236 4158 3163 c

ATOM 1022 N LYS A 167 15.917 17. .485 22. .661 1. .00 91. .65 N

ANISOU 1022 N LYS A 167 12595 13519 8707 3391 4310 3231 N

ATOM 1023 CA LYS A 167 15.713 16. .288 21. .865 1. .00 91. .83 C

ANISOU 1023 CA LYS A 167 12677 13027 9187 3108 4545 3473 C

ATOM 1024 C LYS A 167 16.279 16. .429 20. .460 1. .00 86. .91 C

ANISOU 1024 C LYS A 167 11920 12128 8972 2887 4166 3175 C

ATOM 1025 O LYS A 167 16.394 15. .457 19. .726 1. .00 86. .81 O

ANISOU 1025 O LYS A 167 11983 11695 9307 2690 4281 3318 O

ATOM 1026 CB LYS A 167 14.222 15. .956 21. .777 1. .00 93. .95 c

ANISOU 1026 CB LYS A 167 12777 13147 9771 2742 4999 3534 c

ATOM 1027 N ALA A 168 16.619 17. .648 20. .083 1. .00 83. .19 N

ANISOU 1027 N ALA A 168 11270 11881 8459 2913 3743 2755 N

ATOM 1028 CA ALA A 168 16.968 17. .892 18. .706 1. .00 78. .75 C

ANISOU 1028 CA ALA A 168 10555 11078 8288 2672 3425 2466 C

ATOM 1029 C ALA A 168 18.052 16. .878 18. .331 1. .00 78. .67 C

ANISOU 1029 C ALA A 168 10749 10803 8338 2748 3359 2677 C

ATOM 1030 O ALA A 168 18.740 16. .332 19. .203 1. .00 81. .58 O

ANISOU 1030 O ALA A 168 11362 11282 8354 3083 3437 2978 O

ATOM 1031 CB ALA A 168 17.355 19. .362 18. .480 1. .00 75. .53 c ANISOU 1031 CB ALA A 168 10007 10925 7766 2741 3014 2030 C

ATOM 1032 N LEU A 169 18.107 16. .549 17. .048 1. .00 75. .97 N

ANISOU 1032 N LEU A 169 10310 10121 8437 2456 3259 2544 N

ATOM 1033 CA LEU A 169 19.116 15. .650 16. .492 1. ,00 75. , 60 C

ANISOU 1033 CA LEU A 169 10427 9789 8507 2506 3182 2676 C

ATOM 1034 C LEU A 169 20.449 16. .355 16. .183 1. .00 72. .60 C

ANISOU 1034 C LEU A 169 10016 9621 7948 2702 2702 2435 C

ATOM 1035 O LEU A 169 20.649 17. .533 16. .516 1. .00 71. .23 O

ANISOU 1035 O LEU A 169 9733 9802 7529 2798 2449 2174 O

ATOM 1036 CB LEU A 169 18.560 14. .944 15. .239 1. .00 74. .56 C

ANISOU 1036 CB LEU A 169 10197 9214 8918 2080 3313 2600 C

ATOM 1037 CG LEU A 169 18.133 15. .821 14. .050 1. .00 70. .50 C

ANISOU 1037 CG LEU A 169 9359 8736 8692 1771 3035 2173 c

ATOM 1038 CD1 LEU A 169 19.348 16. .385 13. .314 1. .00 66. .78 c

ANISOU 1038 CD1 LEU A 169 8868 8318 8189 1870 2587 1940 c

ATOM 1039 CD2 LEU A 169 17.212 15. .039 13. .120 1. .00 71. .21 c

ANISOU 1039 CD2 LEU A 169 9313 8502 9242 1336 3274 2121 c

ATOM 1040 N LYS A 170 21.353 15. .613 15. .551 1. .00 72. .06 N

ANISOU 1040 N LYS A 170 10045 9323 8012 2744 2611 2507 N

ATOM 1041 CA LYS A 170 22.649 16. .134 15. .146 1. .00 69. .62 C

ANISOU 1041 CA LYS A 170 9674 9203 7576 2887 2192 2280 C

ATOM 1042 C LYS A 170 22.952 15. .717 13. .721 1. .00 66. .96 C

ANISOU 1042 C LYS A 170 9272 8511 7660 2632 2088 2138 C

ATOM 1043 O LYS A 170 22.295 14. .839 13. .182 1. .00 67. .74 O

ANISOU 1043 O LYS A 170 9420 8216 8102 2403 2356 2254 0

ATOM 1044 CB LYS A 170 23.753 15. .609 16. .053 1. ,00 72. , 77 c

ANISOU 1044 CB LYS A 170 10257 9837 7554 3358 2158 2546 c

ATOM 1045 CG LYS A 170 23.696 16. .089 17. .480 1. .00 75. .68 c

ANISOU 1045 CG LYS A 170 10678 10675 7403 3667 2188 2643 c

ATOM 1046 CD LYS A 170 24.729 15. .367 18. .340 1. .00 79. .70 c

ANISOU 1046 CD LYS A 170 11370 11436 7475 4184 2186 2975 c

ATOM 1047 CE LYS A 170 24.757 15. .958 19. .744 1. .00 82. .77 c

ANISOU 1047 CE LYS A 170 11773 12403 7274 4500 2157 3005 c

ATOM 1048 NZ LYS A 170 25.737 15. .290 20. .634 1. .00 87. .34 N

ANISOU 1048 NZ LYS A 170 12503 13333 7349 5065 2136 3341 N

ATOM 1049 N LEU A 171 23.951 16. .353 13. .119 1. .00 64. .22 N

ANISOU 1049 N LEU A 171 8807 8319 7276 2650 1717 1862 N

ATOM 1050 CA LEU A 171 24.399 16. .017 11. .779 1. .00 61. .85 C

ANISOU 1050 CA LEU A 171 8442 7748 7311 2451 1593 1713 C

ATOM 1051 C LEU A 171 25.903 16. .181 11. .761 1. .00 61. .50 C

ANISOU 1051 C LEU A 171 8377 7953 7037 2704 1295 1624 C

ATOM 1052 O LEU A 171 26.429 17. .084 12. .415 1. .00 61. .53 O

ANISOU 1052 O LEU A 171 8303 8370 6705 2854 1083 1477 O

ATOM 1053 CB LEU A 171 23.770 16. .960 10. .757 1. .00 58. .31 C

ANISOU 1053 CB LEU A 171 7776 7260 7119 2086 1441 1370 C

ATOM 1054 CG LEU A 171 22.253 17. .124 10. .748 1. .00 58. .59 C

ANISOU 1054 CG LEU A 171 7722 7203 7335 1847 1660 1367 C

ATOM 1055 CD1 LEU A 171 21.851 18. ,336 9. ,929 1. ,00 55. , 55 c

ANISOU 1055 CD1 LEU A 171 7127 6913 7065 1645 1440 1039 c

ATOM 1056 CD2 LEU A 171 21.589 15. .879 10. .198 1. .00 60. .10 c

ANISOU 1056 CD2 LEU A 171 7953 7014 7869 1618 1955 1507 c

ATOM 1057 N MET A 172 26.593 15. .310 11. .027 1. .00 61. .60 N

ANISOU 1057 N MET A 172 8443 7737 7225 2743 1293 1683 N

ATOM 1058 CA MET A 172 28.055 15. .359 10. .943 1. .00 61. .71 C

ANISOU 1058 CA MET A 172 8395 8019 7035 2998 1026 1599 C

ATOM 1059 C MET A 172 28.498 16. .030 9. .647 1. .00 57. .99 C

ANISOU 1059 C MET A 172 7721 7528 6783 2698 765 1222 C

ATOM 1060 O MET A 172 28.560 15. .394 8. .599 1. .00 57. .06 O

ANISOU 1060 O MET A 172 7617 7093 6972 2552 816 1195 0

ATOM 1061 CB MET A 172 28.664 13. .959 11. .053 1. .00 64. .98 c

ANISOU 1061 CB MET A 172 9009 8232 7448 3334 1204 1932 c ATOM 1062 N GLY A 173 28.802 17..321 9..728 1..00 56..27 N

ANISOU 1062 N GLY A 173 7338 7642 6401 2600 514 925 N

ATOM 1063 CA GLY A 173 29.240 18. .080 8. .574 1. .00 53. .23 C

ANISOU 1063 CA GLY A 173 6790 7249 6185 2321 298 590 C

ATOM 1064 C GLY A 173 30.539 17. .563 7. .991 1. .00 53. .55 C

ANISOU 1064 C GLY A 173 6757 7367 6223 2442 164 539 C

ATOM 1065 O GLY A 173 30.699 17. .482 6. .765 1. .00 51. .56 O

ANISOU 1065 O GLY A 173 6445 6913 6234 2225 120 399 O

ATOM 1066 N SER A 174 31.472 17. .215 8. .865 1. .00 56. .41 N

ANISOU 1066 N SER A 174 7106 8067 6261 2815 97 647 N

ATOM 1067 CA SER A 174 32.771 16. .694 8. .434 1. .00 57. .47 C

ANISOU 1067 CA SER A 174 7133 8358 6345 3011 -31 608 C

ATOM 1068 C SER A 174 33.908 17. .576 8. .948 1. .00 58. .59 C

ANISOU 1068 C SER A 174 7030 9105 6128 3101 -311 340 C

ATOM 1069 O SER A 174 34.894 17. ,811 8. ,241 1. ,00 58. , 07 O

ANISOU 1069 O SER A 174 6763 9212 6087 3017 -479 100 O

ATOM 1070 CB SER A 174 32.841 16. .592 6. .904 1. .00 54. .71 C

ANISOU 1070 CB SER A 174 6730 7690 6369 2702 -45 435 C

ATOM 1071 OG SER A 174 33.298 17. .808 6. .338 1. .00 52. .53 0

ANISOU 1071 OG SER A 174 6253 7626 6082 2409 -261 72 0

ATOM 1072 N GLY A 177 33.337 17. .850 11. .889 1. .00 64. .30 N

ANISOU 1072 N GLY A 177 7889 10471 6073 3645 -248 633 N

ATOM 1073 CA GLY A 177 32.458 18. .899 12. .417 1. .00 63. .28 C

ANISOU 1073 CA GLY A 177 7790 10373 5881 3406 -225 470 C

ATOM 1074 C GLY A 177 31.046 18. .400 12. .692 1. .00 63. .05 C

ANISOU 1074 C GLY A 177 8013 9927 6016 3397 84 797 C

ATOM 1075 O GLY A 177 30.556 17. ,521 11. ,977 1. ,00 62. , 05 O

ANISOU 1075 O GLY A 177 8015 9329 6232 3331 274 1016 O

ATOM 1076 N GLU A 178 30.393 18. .939 13. .725 1. .00 64. .38 N

ANISOU 1076 N GLU A 178 8238 10284 5938 3445 152 805 N

ATOM 1077 CA GLU A 178 29.040 18. .516 14. .091 1. .00 64. .72 C

ANISOU 1077 CA GLU A 178 8483 10006 6103 3429 467 1102 C

ATOM 1078 C GLU A 178 28.069 19. .680 14. .036 1. .00 62. .58 C

ANISOU 1078 C GLU A 178 8172 9661 5945 3108 485 843 C

ATOM 1079 O GLU A 178 28.374 20. .767 14. .521 1. .00 62. .93 O

ANISOU 1079 O GLU A 178 8124 10042 5745 3075 320 532 O

ATOM 1080 CB GLU A 178 29.025 17. .882 15. .490 1. .00 69. .27 C

ANISOU 1080 CB GLU A 178 9204 10868 6246 3876 616 1456 C

ATOM 1081 CG GLU A 178 29.058 16. .358 15. .494 1. .00 71. .72 c

ANISOU 1081 CG GLU A 178 9730 10882 6637 4162 869 1943 c

ATOM 1082 CD GLU A 178 28.662 15. .769 16. .825 1. .00 76. .28 c

ANISOU 1082 CD GLU A 178 10522 11615 6846 4548 1125 2363 c

ATOM 1083 OE1 GLU A 178 27.458 15. .787 17. .160 1. .00 76. .44 0

ANISOU 1083 OE1 GLU A 178 10661 11418 6966 4388 1401 2492 0

ATOM 1084 OE2 GLU A 178 29.563 15. ,277 17. ,527 1. ,00 80. ,06 0

ANISOU 1084 OE2 GLU A 178 11040 12463 6917 5033 1057 2574 0

ATOM 1085 N PHE A 179 26.900 19. .455 13. .446 1. .00 60. .84 N

ANISOU 1085 N PHE A 179 8014 9012 6091 2878 696 951 N

ATOM 1086 CA PHE A 179 25.879 20. .497 13. .349 1. .00 59. .23 C

ANISOU 1086 CA PHE A 179 7764 8735 6005 2637 736 747 C

ATOM 1087 C PHE A 179 24.758 20. .163 14. .289 1. .00 61. .53 C

ANISOU 1087 C PHE A 179 8159 9025 6196 2747 1030 1004 C

ATOM 1088 O PHE A 179 24.130 19. .118 14. .164 1. .00 62. .41 0

ANISOU 1088 O PHE A 179 8352 8863 6498 2729 1284 1306 0

ATOM 1089 CB PHE A 179 25.330 20. .636 11. .929 1. .00 55. .93 c

ANISOU 1089 CB PHE A 179 7270 7939 6042 2302 731 633 c

ATOM 1090 CG PHE A 179 26.390 20. .771 10. .874 1. .00 53. .85 c

ANISOU 1090 CG PHE A 179 6922 7630 5907 2182 496 436 c

ATOM 1091 CD1 PHE A 179 27.485 21. .622 11. .068 1. .00 53. .95 c

ANISOU 1091 CD1 PHE A 179 6863 7942 5692 2206 260 158 c

ATOM 1092 CD2 PHE A 179 26.296 20. .065 9. .678 1. .00 52. .17 c ANISOU 1092 CD2 PHE A 179 6686 7101 6037 2015 527 493 C

ATOM 1093 CE1 PHE A 179 28.470 21. .755 10. .103 1. .00 52. .39 C

ANISOU 1093 CE1 PHE A 179 6569 7728 5611 2073 74 -26 C

ATOM 1094 CE2 PHE A 179 27.277 20. .195 8. .710 1. .00 50. .50 C

ANISOU 1094 CE2 PHE A 179 6393 6875 5920 1914 329 312 C

ATOM 1095 CZ PHE A 179 28.364 21. .045 8. .919 1. .00 50. .57 C

ANISOU 1095 CZ PHE A 179 6327 7181 5706 1943 110 66 C

ATOM 1096 N LYS A 180 24.527 21. .058 15. .238 1. .00 62. .91 N

ANISOU 1096 N LYS A 180 8331 9503 6068 2841 1018 861 N

ATOM 1097 CA LYS A 180 23.554 20. .841 16. .311 1. .00 65. .70 C

ANISOU 1097 CA LYS A 180 8775 9954 6234 2987 1300 1088 C

ATOM 1098 C LYS A 180 22.559 21. ,997 16. ,320 1. ,00 64. ,76 C

ANISOU 1098 C LYS A 180 8581 9830 6195 2829 1346 834 C

ATOM 1099 O LYS A 180 22.766 23. .009 15. .645 1. .00 62. .44 O

ANISOU 1099 O LYS A 180 8210 9480 6036 2661 1150 496 O

ATOM 1100 CB LYS A 180 24.263 20. .727 17. .665 1. .00 69. .46 C

ANISOU 1100 CB LYS A 180 9335 10898 6158 3358 1267 1184 C

ATOM 1101 CG LYS A 180 25.517 19. .868 17. .629 1. .00 70. .63 C

ANISOU 1101 CG LYS A 180 9516 11162 6160 3591 1128 1351 c

ATOM 1102 CD LYS A 180 26.426 20. .122 18. .820 1. .00 74. .21 c

ANISOU 1102 CD LYS A 180 9956 12228 6013 3947 965 1291 c

ATOM 1103 CE LYS A 180 27.744 19. .396 18. .607 1. .00 75. .27 c

ANISOU 1103 CE LYS A 180 10052 12523 6025 4189 776 1397 c

ATOM 1104 NZ LYS A 180 28.621 19. .371 19. .809 1. .00 79. .79 N

ANISOU 1104 NZ LYS A 180 10591 13765 5961 4624 633 1427 N

ATOM 1105 N ALA A 181 21.473 21. .840 17. .066 1. .00 66. .93 N

ANISOU 1105 N ALA A 181 8891 10150 6390 2898 1632 1013 N

ATOM 1106 CA ALA A 181 20.463 22. .892 17. .193 1. .00 66. .78 C

ANISOU 1106 CA ALA A 181 8795 10164 6414 2823 1711 798 C

ATOM 1107 C ALA A 181 20.988 24. .127 17. .932 1. .00 67. .82 C

ANISOU 1107 C ALA A 181 8964 10613 6192 2949 1545 445 C

ATOM 1108 O ALA A 181 20.583 25. .261 17. .648 1. .00 66. .87 O

ANISOU 1108 O ALA A 181 8806 10424 6177 2857 1504 144 O

ATOM 1109 CB ALA A 181 19.243 22. .342 17. .903 1. .00 69. .49 C

ANISOU 1109 CB ALA A 181 9144 10537 6721 2880 2083 1078 C

ATOM 1110 N GLU A 182 21.891 23. .878 18. .877 1. .00 70. .29 N

ANISOU 1110 N GLU A 182 9355 11275 6075 3172 1464 480 N

ATOM 1111 CA GLU A 182 22.412 24. .876 19. .802 1. .00 72. .48 C

ANISOU 1111 CA GLU A 182 9659 11951 5931 3296 1335 135 C

ATOM 1112 C GLU A 182 23.862 24. ,531 20. ,126 1. ,00 73. , 80 C

ANISOU 1112 C GLU A 182 9814 12455 5772 3438 1084 95 C

ATOM 1113 O GLU A 182 24.276 23. .379 19. .994 1. .00 74. .05 O

ANISOU 1113 O GLU A 182 9867 12460 5807 3566 1095 449 O

ATOM 1114 CB GLU A 182 21.543 24. .918 21. .060 1. .00 76. .08 C

ANISOU 1114 CB GLU A 182 10182 12676 6050 3511 1601 250 C

ATOM 1115 CG GLU A 182 20.890 23. .584 21. .415 1. .00 77. .78 c

ANISOU 1115 CG GLU A 182 10458 12834 6260 3643 1905 794 c

ATOM 1116 CD GLU A 182 19.839 23. .697 22. .516 1. .00 81. .23 c

ANISOU 1116 CD GLU A 182 10941 13492 6429 3801 2224 908 c

ATOM 1117 OE1 GLU A 182 19.587 24. .826 23. .010 1. .00 82. .24 0

ANISOU 1117 OE1 GLU A 182 11052 13823 6372 3834 2200 548 0

ATOM 1118 OE2 GLU A 182 19.263 22. ,648 22. ,895 1. ,00 83. , 31 0

ANISOU 1118 OE2 GLU A 182 11273 13711 6671 3887 2531 1355 0

ATOM 1119 N GLY A 183 24.643 25. .535 20. .504 1. .00 74. .99 N

ANISOU 1119 N GLY A 183 9919 12919 5655 3410 869 -357 N

ATOM 1120 CA GLY A 183 26.081 25. .370 20. .617 1. .00 76. .17 C

ANISOU 1120 CA GLY A 183 9972 13431 5538 3483 585 -498 C

ATOM 1121 C GLY A 183 26.719 26. .541 19. .921 1. .00 74. .49 C

ANISOU 1121 C GLY A 183 9675 13123 5506 3150 377 - 1032 C

ATOM 1122 O GLY A 183 26.071 27. .553 19. .706 1. .00 73. .60 0

ANISOU 1122 O GLY A 183 9629 12752 5586 2955 468 - 1297 0 ATOM 1123 N ASN A 184 27.992 26..434 19..575 1..00 74..52 N

ANISOU 1123 N ASN A 184 9537 13331 5446 3092 122 - 1194 N

ATOM 1124 CA ASN A 184 28.643 27. .529 18. .887 1. .00 73. .37 C

ANISOU 1124 CA ASN A 184 9317 13075 5486 2728 -34 - 1699 C

ATOM 1125 C ASN A 184 27.789 27. .868 17. .695 1. .00 69. .32 C

ANISOU 1125 C ASN A 184 8912 11895 5532 2481 104 - 1627 C

ATOM 1126 O ASN A 184 27.321 26. .978 16. .989 1. .00 66. .73 O

ANISOU 1126 O ASN A 184 8600 11260 5493 2525 182 - 1227 O

ATOM 1127 CB ASN A 184 30.041 27. .143 18. .427 1. ,00 73. , 44 C

ANISOU 1127 CB ASN A 184 9124 13335 5447 2683 -292 - 1793 C

ATOM 1128 N SER A 185 27.551 29. .154 17. .493 1. .00 69. .30 N

ANISOU 1128 N SER A 185 8991 11674 5664 2240 153 - 2016 N

ATOM 1129 CA SER A 185 26.633 29. .586 16. .454 1. .00 66. .24 C

ANISOU 1129 CA SER A 185 8718 10707 5744 2085 297 - 1934 C

ATOM 1130 C SER A 185 27.125 29. .161 15. .084 1. .00 62. .91 C

ANISOU 1130 C SER A 185 8224 10003 5677 1906 187 - 1805 C

ATOM 1131 O SER A 185 26.354 28. .669 14. .261 1. .00 60. .24 O

ANISOU 1131 O SER A 185 7904 9330 5655 1913 275 - 1495 O

ATOM 1132 CB SER A 185 26.457 31. .099 16. .501 1. .00 67. .64 C

ANISOU 1132 CB SER A 185 9038 10688 5976 1899 383 - 2384 C

ATOM 1133 N LYS A 186 28.418 29. .338 14. .851 1. .00 63. .46 N

ANISOU 1133 N LYS A 186 8184 10256 5672 1736 -2 - 2068 N

ATOM 1134 CA LYS A 186 28.992 29. .002 13. .559 1. .00 60. .69 C

ANISOU 1134 CA LYS A 186 7757 9677 5626 1558 -100 - 1989 C

ATOM 1135 C LYS A 186 28.692 27. .548 13. .108 1. .00 58. .53 C

ANISOU 1135 C LYS A 186 7427 9323 5487 1747 -93 - 1502 C

ATOM 1136 O LYS A 186 28.787 27. .232 11. .913 1. .00 55. .88 O

ANISOU 1136 O LYS A 186 7065 8705 5463 1614 -120 - 1391 O

ATOM 1137 CB LYS A 186 30.496 29. .302 13. .550 1. .00 62. .39 C

ANISOU 1137 CB LYS A 186 7807 10218 5680 1370 -296 - 2354 C

ATOM 1138 N PHE A 187 28.297 26. .692 14. .063 1. .00 60. .06 N

ANISOU 1138 N PHE A 187 7630 9746 5446 2047 -25 - 1223 N

ATOM 1139 CA PHE A 187 28.045 25. .254 13. .816 1. .00 59. .09 C

ANISOU 1139 CA PHE A 187 7498 9527 5426 2230 38 -769 C

ATOM 1140 C PHE A 187 26.626 24. .777 14. .111 1. .00 58. .99 C

ANISOU 1140 C PHE A 187 7592 9311 5512 2344 289 -445 C

ATOM 1141 O PHE A 187 26.378 23. .571 14. .305 1. ,00 59. , 61 O

ANISOU 1141 O PHE A 187 7701 9360 5589 2517 407 -74 O

ATOM 1142 CB PHE A 187 29.053 24. .404 14. .581 1. .00 61. .75 C

ANISOU 1142 CB PHE A 187 7753 10307 5401 2510 -76 -653 C

ATOM 1143 CG PHE A 187 30.440 24. .537 14. .055 1. .00 61. .72 c

ANISOU 1143 CG PHE A 187 7578 10505 5370 2405 -312 -902 c

ATOM 1144 CD1 PHE A 187 31.234 25. .611 14. .439 1. .00 63. .59 c

ANISOU 1144 CD1 PHE A 187 7699 11082 5379 2251 -467 - 1371 c

ATOM 1145 CD2 PHE A 187 30.947 23. .616 13. .140 1. .00 60. .17 c

ANISOU 1145 CD2 PHE A 187 7323 10153 5388 2427 -359 -709 c

ATOM 1146 CE1 PHE A 187 32.523 25. .761 13. .947 1. .00 64. .01 c

ANISOU 1146 CE1 PHE A 187 7549 11361 5410 2109 - 666 - 1635 c

ATOM 1147 CE2 PHE A 187 32.235 23. .746 12. .654 1. .00 60. .45 c

ANISOU 1147 CE2 PHE A 187 7166 10414 5387 2337 -563 -949 c

ATOM 1148 CZ PHE A 187 33.024 24. .825 13. .058 1. .00 62. .38 c

ANISOU 1148 CZ PHE A 187 7264 11036 5400 2168 -717 - 1411 c

ATOM 1149 N THR A 188 25.700 25. .729 14. .143 1. .00 58. .67 N

ANISOU 1149 N THR A 188 7609 9121 5563 2246 398 -591 N

ATOM 1150 CA THR A 188 24.304 25. .399 14. .359 1. .00 58. .83 C

ANISOU 1150 CA THR A 188 7671 8990 5690 2323 641 -336 C

ATOM 1151 C THR A 188 23.546 25. .410 13. .055 1. .00 56. .02 c

ANISOU 1151 C THR A 188 7269 8246 5770 2129 689 -275 c

ATOM 1152 O THR A 188 23.570 26. .404 12. .319 1. .00 54. .66 0

ANISOU 1152 O THR A 188 7102 7909 5755 1981 610 -511 0

ATOM 1153 CB THR A 188 23.608 26. .341 15. .365 1. .00 61. .07 c ANISOU 1153 CB THR A 188 8021 9431 5751 2423 765 -504 C

ATOM 1154 OG1 THR A 188 23.943 27. .702 15. .073 1. .00 60. .79 O

ANISOU 1154 OG1 THR A 188 8027 9319 5752 2271 664 -913 O

ATOM 1155 CG2 THR A 188 24.025 26. .011 16. .789 1. .00 64. .52 C

ANISOU 1155 CG2 THR A 188 8494 10313 5709 2672 781 -458 C

ATOM 1156 N TYR A 189 22.887 24. .291 12. .769 1. .00 55. .66 N

ANISOU 1156 N TYR A 189 7183 8061 5904 2131 832 38 N

ATOM 1157 CA TYR A 189 21.936 24. .235 11. .666 1. .00 53. .84 C

ANISOU 1157 CA TYR A 189 6859 7559 6039 1961 901 86 C

ATOM 1158 C TYR A 189 20.731 25. .103 11. .988 1. .00 54. .80 C

ANISOU 1158 C TYR A 189 6952 7707 6163 2014 1042 14 C

ATOM 1159 O TYR A 189 20.442 25. .392 13. .152 1. .00 57. .06 O

ANISOU 1159 O TYR A 189 7297 8191 6193 2177 1160 8 O

ATOM 1160 CB TYR A 189 21.475 22. .799 11. .367 1. .00 54. .05 C

ANISOU 1160 CB TYR A 189 6837 7445 6255 1903 1058 383 C

ATOM 1161 CG TYR A 189 20.871 22. .058 12. .542 1. ,00 56. , 98 C

ANISOU 1161 CG TYR A 189 7264 7924 6460 2049 1324 645 c

ATOM 1162 CD1 TYR A 189 19.597 22. .372 13. .031 1. .00 58. .47 c

ANISOU 1162 CD1 TYR A 189 7386 8184 6647 2064 1538 679 c

ATOM 1163 CD2 TYR A 189 21.566 21. .025 13. .154 1. .00 58. .69 c

ANISOU 1163 CD2 TYR A 189 7606 8182 6513 2197 1387 882 c

ATOM 1164 CE1 TYR A 189 19.045 21. .689 14. .107 1. .00 61. .51 c

ANISOU 1164 CE1 TYR A 189 7829 8674 6870 2180 1819 933 c

ATOM 1165 CE2 TYR A 189 21.022 20. .329 14. .225 1. .00 61. .87 c

ANISOU 1165 CE2 TYR A 189 8102 8662 6745 2347 1670 1170 c

ATOM 1166 CZ TYR A 189 19.764 20. .660 14. .701 1. .00 63. .24 c

ANISOU 1166 CZ TYR A 189 8209 8899 6920 2315 1894 1193 c

ATOM 1167 OH TYR A 189 19.250 19. ,958 15. ,775 1. ,00 66. , 75 0

ANISOU 1167 OH TYR A 189 8755 9428 7180 2451 2210 1494 0

ATOM 1168 N THR A 190 20.035 25. .507 10. .938 1. .00 53. .41 N

ANISOU 1168 N THR A 190 6676 7364 6254 1906 1031 -39 N

ATOM 1169 CA THR A 190 18.772 26. .194 11. .065 1. .00 54. .59 C

ANISOU 1169 CA THR A 190 6749 7548 6445 1995 1175 -69 c

ATOM 1170 C THR A 190 17.682 25. .224 10. .630 1. .00 54. .96 c

ANISOU 1170 C THR A 190 6585 7591 6707 1896 1328 131 c

ATOM 1171 O THR A 190 17.940 24. .324 9. .848 1. .00 53. .73 0

ANISOU 1171 O THR A 190 6366 7318 6732 1721 1277 215 0

ATOM 1172 CB THR A 190 18.756 27. .442 10. .165 1. .00 53. .55 c

ANISOU 1172 CB THR A 190 6651 7268 6429 1996 1056 -270 c

ATOM 1173 OG1 THR A 190 18.521 27. .058 8. .806 1. .00 51. .84 0

ANISOU 1173 OG1 THR A 190 6292 6934 6471 1858 972 -203 0

ATOM 1174 CG2 THR A 190 20.093 28. .148 10. .236 1. .00 52. .96 c

ANISOU 1174 CG2 THR A 190 6770 7124 6229 1950 896 -487 c

ATOM 1175 N VAL A 191 16.470 25. .401 11. .144 1. .00 57. .06 N

ANISOU 1175 N VAL A 191 6727 7999 6953 1992 1532 175 N

ATOM 1176 CA VAL A 191 15.332 24. .586 10. .728 1. .00 58. .09 C

ANISOU 1176 CA VAL A 191 6598 8179 7294 1854 1697 303 C

ATOM 1177 C VAL A 191 14.430 25. .398 9. .827 1. .00 58. .10 c

ANISOU 1177 C VAL A 191 6387 8247 7439 1906 1638 181 c

ATOM 1178 O VAL A 191 14.137 26. .559 10. .111 1. .00 58. .90 0

ANISOU 1178 O VAL A 191 6539 8410 7431 2140 1638 71 0

ATOM 1179 CB VAL A 191 14.517 24. .058 11. .922 1. .00 61. .18 c

ANISOU 1179 CB VAL A 191 6937 8744 7564 1905 2011 462 c

ATOM 1180 CGI VAL A 191 13.213 23. .434 11. .454 1. .00 62. .87 c

ANISOU 1180 CGI VAL A 191 6824 9053 8012 1724 2203 520 c

ATOM 1181 CG2 VAL A 191 15.319 23. ,027 12. ,688 1. ,00 61. ,79 c

ANISOU 1181 CG2 VAL A 191 7219 8754 7506 1876 2102 662 c

ATOM 1182 N LEU A 192 13.990 24. .768 8. .745 1. .00 57. .67 N

ANISOU 1182 N LEU A 192 6101 8194 7617 1706 1598 193 N

ATOM 1183 CA LEU A 192 13.170 25. .427 7. .731 1. .00 58. .02 C

ANISOU 1183 CA LEU A 192 5904 8371 7769 1778 1505 94 C ATOM 1184 C LEU A 192 11.678 25..142 7..907 1..00 61..13 C

ANISOU 1184 C LEU A 192 5925 9074 8227 1769 1714 114 C

ATOM 1185 O LEU A 192 10.826 25. .969 7. .565 1. .00 62. .59 O

ANISOU 1185 O LEU A 192 5911 9474 8398 1988 1692 46 O

ATOM 1186 CB LEU A 192 13.639 25. .032 6. .332 1. .00 56. .03 C

ANISOU 1186 CB LEU A 192 5592 8016 7682 1582 1294 46 C

ATOM 1187 CG LEU A 192 15.046 25. .493 5. .927 1. .00 53. .25 C

ANISOU 1187 CG LEU A 192 5547 7407 7278 1599 1080 -2 C

ATOM 1188 CD1 LEU A 192 15.120 25. .539 4. .425 1. .00 52. .13 C

ANISOU 1188 CD1 LEU A 192 5289 7261 7256 1513 888 -65 C

ATOM 1189 CD2 LEU A 192 15.449 26. .857 6. .471 1. .00 53. .22 C

ANISOU 1189 CD2 LEU A 192 5796 7321 7103 1861 1048 -72 C

ATOM 1190 N GLU A 193 11.372 23. .961 8. .436 1. .00 62. .59 N

ANISOU 1190 N GLU A 193 6017 9284 8479 1523 1937 212 N

ATOM 1191 CA GLU A 193 10.032 23. .658 8. .937 1. .00 66. .15 C

ANISOU 1191 CA GLU A 193 6141 10033 8962 1479 2214 233 C

ATOM 1192 C GLU A 193 10.108 22. .584 10. .018 1. .00 67. .76 C

ANISOU 1192 C GLU A 193 6471 10135 9140 1294 2521 409 C

ATOM 1193 O GLU A 193 11.062 21. .816 10. .047 1. .00 66. .32 O

ANISOU 1193 O GLU A 193 6547 9665 8987 1148 2502 509 O

ATOM 1194 CB GLU A 193 9.110 23. .237 7. .799 1. .00 67. .61 C

ANISOU 1194 CB GLU A 193 5877 10456 9355 1261 2179 110 C

ATOM 1195 CG GLU A 193 9.461 21. ,901 7. ,169 1. ,00 67. ,19 c

ANISOU 1195 CG GLU A 193 5800 10213 9516 824 2202 98 c

ATOM 1196 CD GLU A 193 8.602 21. .579 5. .955 1. .00 68. .89 c

ANISOU 1196 CD GLU A 193 5551 10721 9905 596 2125 -102 c

ATOM 1197 OE1 GLU A 193 8.618 22. .361 4. .975 1. .00 67. .76 0

ANISOU 1197 OE1 GLU A 193 5301 10731 9714 788 1836 -208 0

ATOM 1198 OE2 GLU A 193 7.906 20. .540 5. .979 1. .00 71. .83 0

ANISOU 1198 OE2 GLU A 193 5664 11182 10448 217 2369 -159 0

ATOM 1199 N ASP A 194 9.135 22. .522 10. .917 1. .00 71. .09 N

ANISOU 1199 N ASP A 194 6728 10791 9492 1329 2823 469 N

ATOM 1200 CA ASP A 194 9.220 21. .527 11. .981 1. .00 73. .12 C

ANISOU 1200 CA ASP A 194 7153 10938 9692 1183 3154 686 C

ATOM 1201 C ASP A 194 7.926 20. .792 12. .254 1. .00 77. .41 C

ANISOU 1201 C ASP A 194 7349 11697 10368 919 3537 720 C

ATOM 1202 O ASP A 194 7.251 21. .066 13. .234 1. .00 80. .17 0

ANISOU 1202 O ASP A 194 7626 12278 10556 1060 3789 786 0

ATOM 1203 CB ASP A 194 9.714 22. .136 13. .278 1. .00 73. .28 c

ANISOU 1203 CB ASP A 194 7492 10979 9373 1520 3208 791 c

ATOM 1204 CG ASP A 194 9.778 21. .121 14. .375 1. ,00 75. , 92 c

ANISOU 1204 CG ASP A 194 8010 11241 9594 1428 3558 1060 c

ATOM 1205 OD1 ASP A 194 9.192 20. .040 14. .190 1. .00 78. .22 0

ANISOU 1205 OD1 ASP A 194 8149 11466 10105 1092 3830 1156 0

ATOM 1206 OD2 ASP A 194 10.418 21. .383 15. .405 1. .00 76. .11 0

ANISOU 1206 OD2 ASP A 194 8337 11276 9305 1683 3577 1170 0

ATOM 1207 N GLY A 195 7.614 19. .837 11. .392 1. .00 78. .31 N

ANISOU 1207 N GLY A 195 7246 11735 10773 508 3599 651 N

ATOM 1208 CA GLY A 195 6.458 18. .956 11. .535 1. .00 82. .89 C

ANISOU 1208 CA GLY A 195 7483 12474 11536 127 3995 640 C

ATOM 1209 C GLY A 195 6.522 18. .038 12. .735 1. .00 85. .78 C

ANISOU 1209 C GLY A 195 8128 12622 11841 2 4446 935 c

ATOM 1210 O GLY A 195 5.508 17. ,812 13. ,385 1. ,00 89. , 96 0

ANISOU 1210 O GLY A 195 8426 13385 12369 -127 4823 979 0

ATOM 1211 N CYS A 196 7.696 17. .467 12. .984 1. .00 84. .02 N

ANISOU 1211 N CYS A 196 8386 11970 11567 42 4425 1147 N

ATOM 1212 CA CYS A 196 7.876 16. .455 14. .016 1. .00 87. .14 C

ANISOU 1212 CA CYS A 196 9109 12100 11900 -46 4859 1484 C

ATOM 1213 C CYS A 196 8.128 17. .114 15. .379 1. .00 87. .56 C

ANISOU 1213 C CYS A 196 9412 12327 11529 401 4920 1696 C

ATOM 1214 O CYS A 196 9.260 17. .095 15. .889 1. .00 85. .92 O ANISOU 1214 O CYS A 196 9624 11937 11085 681 4798 1887 O

ATOM 1215 CB CYS A 196 9.070 15. .551 13. .699 1. .00 85. .61 C

ANISOU 1215 CB CYS A 196 9328 11399 11800 -111 4804 1639 C

ATOM 1216 SG CYS A 196 9.061 14. .678 12. .169 1. .00 85. .18 S

ANISOU 1216 SG CYS A 196 9106 11058 12199 -604 4735 1390 S

ATOM 1217 N THR A 197 7.090 17. .693 15. .961 1. .00 90. .08 N

ANISOU 1217 N THR A 197 9453 13043 11732 479 5104 1640 N

ATOM 1218 CA THR A 197 7.227 18. .278 17. .286 1. .00 91. .21 C

ANISOU 1218 CA THR A 197 9815 13384 11456 878 5207 1807 C

ATOM 1219 C THR A 197 6.278 17. .665 18. .310 1. .00 96. .80 C

ANISOU 1219 C THR A 197 10456 14236 12089 739 5783 2031 C

ATOM 1220 O THR A 197 6.410 17. .913 19. .513 1. .00 98. .60 O

ANISOU 1220 O THR A 197 10913 14613 11936 1045 5948 2227 O

ATOM 1221 CB THR A 197 6.995 19. .791 17. .244 1. .00 89. .23 C

ANISOU 1221 CB THR A 197 9377 13491 11036 1233 4897 1533 C

ATOM 1222 OG1 THR A 197 5.609 20. .038 17. .005 1. .00 91. .97 0

ANISOU 1222 OG1 THR A 197 9221 14189 11536 1100 5074 1362 0

ATOM 1223 CG2 THR A 197 7.801 20. .407 16. .130 1. .00 84. .32 c

ANISOU 1223 CG2 THR A 197 8793 12718 10527 1317 4386 1313 c

ATOM 1224 N LYS A 198 5.323 16. ,873 17. , 829 1. ,00 99. , 94 N

ANISOU 1224 N LYS A 198 10528 14612 12833 259 6100 1979 N

ATOM 1225 CA LYS A 198 4.343 16. .222 18. .697 1. .00105. .87 C

ANISOU 1225 CA LYS A 198 11172 15483 13569 30 6707 2173 C

ATOM 1226 C LYS A 198 4.364 14. .733 18. .393 1. .00108. .74 C

ANISOU 1226 C LYS A 198 11682 15371 14263 -481 7085 2346 C

ATOM 1227 O LYS A 198 4.611 14. .331 17. .266 1. .00106. .78 O

ANISOU 1227 O LYS A 198 11354 14872 14346 -767 6885 2156 O

ATOM 1228 CB LYS A 198 2.944 16. .798 18. .475 1. .00108. .29 c

ANISOU 1228 CB LYS A 198 10844 16314 13986 -99 6804 1875 c

ATOM 1229 N HIS A 199 4.107 13. .907 19. .389 1. .00113. .78 N

ANISOU 1229 N HIS A 199 12561 15863 14809 -597 7658 2707 N

ATOM 1230 CA HIS A 199 4.332 12. .482 19. .209 1. .00116. .80 C

ANISOU 1230 CA HIS A 199 13239 15663 15477 -1009 8053 2936 C

ATOM 1231 C HIS A 199 3.333 11. .784 18. .335 1. .00120. .05 C

ANISOU 1231 C HIS A 199 13213 16012 16391 -1709 8332 2648 C

ATOM 1232 O HIS A 199 3.697 10. .901 17. .545 1. .00120. .13 O

ANISOU 1232 O HIS A 199 13363 15540 16742 -2062 8372 2594 O

ATOM 1233 CB HIS A 199 4.406 11. .789 20. .562 1. .00121. .85 c

ANISOU 1233 CB HIS A 199 14337 16120 15842 -885 8625 3467 c

ATOM 1234 CG HIS A 199 5.805 11. .360 20. .961 1. .00120. .39 c

ANISOU 1234 CG HIS A 199 14813 15518 15410 -474 8514 3862 c

ATOM 1235 ND1 HIS A 199 6.718 12. .220 21. .453 1. .00116. .64 N

ANISOU 1235 ND1 HIS A 199 14549 15288 14483 137 8070 3926 N

ATOM 1236 CD2 HIS A 199 6.421 10. .111 20. .933 1. .00122. .89 C

ANISOU 1236 CD2 HIS A 199 15615 15197 15880 -593 8824 4206 C

ATOM 1237 CE1 HIS A 199 7.854 11. .561 21. .726 1. .00116. .74 C

ANISOU 1237 CE1 HIS A 199 15099 14915 14341 408 8066 4287 C

ATOM 1238 NE2 HIS A 199 7.672 10. ,271 21. ,414 1. , 00120. , 55 N

ANISOU 1238 NE2 HIS A 199 15769 14842 15193 -6 8533 4483 N

ATOM 1239 N THR A 200 2.067 12. .180 18. .456 1. .00123. .12 N

ANISOU 1239 N THR A 200 13041 16918 16820 -1916 8526 2425 N

ATOM 1240 CA THR A 200 0.929 11. .348 17. .995 1. .00128. .68 C

ANISOU 1240 CA THR A 200 13307 17637 17949 -2655 8992 2202 C

ATOM 1241 C THR A 200 0.823 11. .090 16. .488 1. .00127. .11 C

ANISOU 1241 C THR A 200 12746 17378 18171 -3095 8696 1735 C

ATOM 1242 O THR A 200 1.074 11. .988 15. .671 1. .00121. .98 O

ANISOU 1242 O THR A 200 11851 17022 17474 -2821 8073 1442 O

ATOM 1243 CB THR A 200 -0.424 11. .874 18. .514 1. .00132. .84 C

ANISOU 1243 CB THR A 200 13247 18837 18387 -2744 9267 2052 C

ATOM 1244 N GLY A 201 0.431 9. .856 16. .153 1. .00132. .12 N

ANISOU 1244 N GLY A 201 13365 17631 19205 -3785 9183 1668 N ATOM 1245 CA GLY A 201 0.333 9..407 14..774 1..00131..82 C

ANISOU 1245 CA GLY A 201 13025 17490 19570 -4284 8991 1211 C

ATOM 1246 C GLY A 201 0.444 10. .627 13. .893 1. .00125. .90 C

ANISOU 1246 C GLY A 201 11865 17285 18684 -3899 8227 861 C

ATOM 1247 O GLY A 201 0.440 10. .527 12. .681 1. .00124. .61 O

ANISOU 1247 O GLY A 201 11417 17176 18752 -4163 7921 468 O

ATOM 1248 N TRP A 203 3.600 10. .503 11. .631 1. .00111. .98 N

ANISOU 1248 N TRP A 203 11009 14497 17043 -3424 7008 750 N

ATOM 1249 CA TRP A 203 4.595 10. .494 10. .570 1. .00107. .39 C

ANISOU 1249 CA TRP A 203 10605 13661 16538 -3329 6547 598 C

ATOM 1250 C TRP A 203 4.580 11. .793 9. .814 1. .00102. .61 C

ANISOU 1250 C TRP A 203 9611 13625 15753 -2979 5905 323 C

ATOM 1251 O TRP A 203 3.805 11. .956 8. .870 1. .00103. .81 O

ANISOU 1251 O TRP A 203 9199 14199 16047 -3266 5747 -94 O

ATOM 1252 CB TRP A 203 4.368 9. .325 9. .630 1. .00110. .93 C

ANISOU 1252 CB TRP A 203 10957 13777 17414 -4008 6783 283 C

ATOM 1253 CG TRP A 203 4.638 7. .990 10. .271 1. ,00115. ,49 c

ANISOU 1253 CG TRP A 203 12076 13608 18195 -4299 7420 594 c

ATOM 1254 CD1 TRP A 203 3.724 7. .140 10. .896 1. .00122. .56 c

ANISOU 1254 CD1 TRP A 203 12926 14342 19299 -4816 8120 659 c

ATOM 1255 CD2 TRP A 203 5.931 7. .308 10. .387 1. .00114. .00 c

ANISOU 1255 CD2 TRP A 203 12599 12694 18021 -4067 7470 922 c

ATOM 1256 NE1 TRP A 203 4.344 6. .015 11. .374 1. .00125. .55 N

ANISOU 1256 NE1 TRP A 203 13970 13915 19819 -4904 8606 1022 N

ATOM 1257 CE2 TRP A 203 5.667 6. .047 11. .100 1. .00120. .73 C

ANISOU 1257 CE2 TRP A 203 13829 12947 19096 -4442 8239 1198 C

ATOM 1258 CE3 TRP A 203 7.231 7. .605 10. .004 1. .00108. .43 C

ANISOU 1258 CE3 TRP A 203 12238 11796 17165 -3590 6998 1021 C

ATOM 1259 CZ2 TRP A 203 6.677 5. .147 11. .398 1. .00121. .76 C

ANISOU 1259 CZ2 TRP A 203 14670 12315 19277 -4270 8496 1579 c

ATOM 1260 CZ3 TRP A 203 8.231 6. .676 10. .295 1. .00109. .46 c

ANISOU 1260 CZ3 TRP A 203 13022 11214 17354 -3453 7245 1365 c

ATOM 1261 CH2 TRP A 203 7.963 5. .484 10. .979 1. .00115. .96 c

ANISOU 1261 CH2 TRP A 203 14220 11466 18375 -3750 7968 1651 c

ATOM 1262 N SER A 204 5.446 12. .702 10. .256 1. .00 97. .75 N

ANISOU 1262 N SER A 204 9309 13021 14811 -2356 5559 564 N

ATOM 1263 CA SER A 204 5.604 14. .069 9. .755 1. .00 93. .15 C

ANISOU 1263 CA SER A 204 8511 12872 14009 -1913 4992 405 C

ATOM 1264 C SER A 204 7.064 14. .475 9. .555 1. .00 87. .59 C

ANISOU 1264 C SER A 204 8275 11862 13144 -1501 4586 543 C

ATOM 1265 O SER A 204 7.968 13. .870 10. .123 1. .00 87. .17 O

ANISOU 1265 O SER A 204 8722 11351 13049 -1411 4731 831 0

ATOM 1266 CB SER A 204 4.890 15. .067 10. .667 1. .00 94. .00 c

ANISOU 1266 CB SER A 204 8413 13453 13849 -1567 5038 491 c

ATOM 1267 OG SER A 204 5.052 16. ,398 10. ,191 1. ,00 90. ,09 0

ANISOU 1267 OG SER A 204 7772 13299 13160 -1121 4537 352 0

ATOM 1268 N LYS A 205 7.257 15. .470 8. .683 1. .00 83. .91 N

ANISOU 1268 N LYS A 205 7615 11673 12592 -1263 4094 327 N

ATOM 1269 CA LYS A 205 8.572 15. .889 8. .195 1. .00 78. .91 C

ANISOU 1269 CA LYS A 205 7321 10807 11854 -967 3686 362 C

ATOM 1270 C LYS A 205 9.130 17. .179 8. .826 1. .00 75. .62 C

ANISOU 1270 C LYS A 205 7105 10525 11103 -411 3423 498 C

ATOM 1271 O LYS A 205 8.426 18. .179 8. .939 1. .00 75. .88 O

ANISOU 1271 O LYS A 205 6870 10952 11007 -195 3329 407 0

ATOM 1272 CB LYS A 205 8.513 16. .055 6. .677 1. .00 77. .44 c

ANISOU 1272 CB LYS A 205 6834 10782 11807 -1122 3344 26 c

ATOM 1273 N THR A 206 10.401 17. .139 9. .234 1. .00 73. .03 N

ANISOU 1273 N THR A 206 7240 9874 10634 -182 3318 692 N

ATOM 1274 CA THR A 206 11.168 18. .339 9. .597 1. .00 69. .73 C

ANISOU 1274 CA THR A 206 7025 9542 9927 271 3013 730 C

ATOM 1275 C THR A 206 12.247 18. .554 8. .536 1. .00 65. .89 C ANISOU 1275 C THR A 206 6666 8884 9487 308 2632 609 C

ATOM 1276 O THR A 206 12.759 17. .587 7. .975 1. .00 65. .72 O

ANISOU 1276 O THR A 206 6746 8580 9642 81 2657 611 O

ATOM 1277 CB THR A 206 11.855 18. .236 10. .980 1. .00 70. .24 C

ANISOU 1277 CB THR A 206 7482 9482 9724 529 3166 1015 C

ATOM 1278 OG1 THR A 206 10.881 18. .247 12. .010 1. .00 73. .73 O

ANISOU 1278 OG1 THR A 206 7820 10135 10060 555 3505 1129 O

ATOM 1279 CG2 THR A 206 12.771 19. .427 11. .233 1. .00 67. .10 C

ANISOU 1279 CG2 THR A 206 7280 9165 9048 917 2831 967 C

ATOM 1280 N VAL A 207 12.583 19. .821 8. .261 1. .00 63. .24 N

ANISOU 1280 N VAL A 207 6335 8696 8996 592 2315 499 N

ATOM 1281 CA VAL A 207 13.616 20. .173 7. .272 1. ,00 59. , 82 C

ANISOU 1281 CA VAL A 207 6022 8125 8580 636 1972 388 C

ATOM 1282 C VAL A 207 14.710 21. .011 7. .918 1. .00 57. .69 C

ANISOU 1282 C VAL A 207 6071 7791 8058 947 1806 442 C

ATOM 1283 O VAL A 207 14.431 22. .061 8. .504 1. .00 57. .94 O

ANISOU 1283 O VAL A 207 6112 7989 7913 1188 1786 412 O

ATOM 1284 CB VAL A 207 13.041 20. .959 6. .078 1. .00 59. .11 C

ANISOU 1284 CB VAL A 207 5637 8262 8557 646 1744 177 C

ATOM 1285 CGI VAL A 207 14.149 21. .366 5. .119 1. .00 55. .88 C

ANISOU 1285 CGI VAL A 207 5392 7705 8137 699 1429 94 c

ATOM 1286 CG2 VAL A 207 11.988 20. .136 5. .354 1. .00 61. .64 c

ANISOU 1286 CG2 VAL A 207 5578 8739 9101 310 1867 52 c

ATOM 1287 N PHE A 208 15.949 20. ,540 7. ,796 1. ,00 56. , 03 N

ANISOU 1287 N PHE A 208 6101 7355 7832 935 1698 491 N

ATOM 1288 CA PHE A 208 17.108 21. .236 8. .357 1. .00 54. .43 C

ANISOU 1288 CA PHE A 208 6156 7139 7388 1176 1527 495 C

ATOM 1289 C PHE A 208 17.950 21. .862 7. .263 1. .00 51. .61 C

ANISOU 1289 C PHE A 208 5825 6711 7073 1161 1224 322 C

ATOM 1290 O PHE A 208 17.803 21. .510 6. .098 1. .00 50. .81 O

ANISOU 1290 O PHE A 208 5588 6546 7172 979 1148 246 O

ATOM 1291 CB PHE A 208 17.977 20. .271 9. .154 1. .00 55. .33 c

ANISOU 1291 CB PHE A 208 6503 7127 7393 1234 1633 693 c

ATOM 1292 CG PHE A 208 17.267 19. .632 10. .303 1. .00 58. .56 c

ANISOU 1292 CG PHE A 208 6951 7581 7718 1273 1969 916 c

ATOM 1293 CD1 PHE A 208 16.381 18. ,585 10. ,081 1. ,00 60. , 73 c

ANISOU 1293 CD1 PHE A 208 7112 7728 8234 1019 2251 1014 c

ATOM 1294 CD2 PHE A 208 17.490 20. .068 11. .612 1. .00 59. .90 c

ANISOU 1294 CD2 PHE A 208 7271 7932 7556 1541 2027 1012 c

ATOM 1295 CE1 PHE A 208 15.726 17. .979 11. .141 1. .00 64. .18 c

ANISOU 1295 CE1 PHE A 208 7603 8182 8600 1028 2614 1240 c

ATOM 1296 CE2 PHE A 208 16.836 19. .467 12. .677 1. .00 63. .23 c

ANISOU 1296 CE2 PHE A 208 7746 8412 7869 1591 2364 1248 c

ATOM 1297 CZ PHE A 208 15.948 18. .423 12. .440 1. .00 65. .38 c

ANISOU 1297 CZ PHE A 208 7920 8520 8400 1332 2673 1380 c

ATOM 1298 N GLU A 209 18.827 22. .787 7. .643 1. .00 50. .52 N

ANISOU 1298 N GLU A 209 5857 6602 6738 1331 1069 243 N

ATOM 1299 CA GLU A 209 19.741 23. .394 6. .687 1. .00 48. .27 C

ANISOU 1299 CA GLU A 209 5625 6233 6482 1293 825 90 c

ATOM 1300 C GLU A 209 21.038 23. .911 7. .292 1. .00 47. .77 c

ANISOU 1300 C GLU A 209 5755 6191 6203 1397 701 9 c

ATOM 1301 O GLU A 209 21.039 24. .602 8. .334 1. .00 48. .98 0

ANISOU 1301 O GLU A 209 6000 6464 6146 1548 744 -39 0

ATOM 1302 CB GLU A 209 19.063 24. .526 5. .935 1. .00 47. .91 c

ANISOU 1302 CB GLU A 209 5488 6222 6492 1332 752 -31 c

ATOM 1303 CG GLU A 209 19.955 25. .128 4. .858 1. .00 46. .02 c

ANISOU 1303 CG GLU A 209 5327 5871 6288 1274 546 -154 c

ATOM 1304 CD GLU A 209 19.271 26. .221 4. .077 1. .00 46. .27 c

ANISOU 1304 CD GLU A 209 5311 5914 6355 1368 503 -213 c

ATOM 1305 OE1 GLU A 209 18.873 27. .236 4. .709 1. .00 47. .50 0

ANISOU 1305 OE1 GLU A 209 5556 6084 6408 1556 575 -249 0 ATOM 1306 OE2 GLU A 209 19.141 26..048 2..834 1..00 45..61 O

ANISOU 1306 OE2 GLU A 209 5112 5832 6384 1279 407 -221 O

ATOM 1307 N TYR A 210 22.139 23. .588 6. .619 1. .00 46. .33 N

ANISOU 1307 N TYR A 210 5609 5929 6065 1306 550 -41 N

ATOM 1308 CA TYR A 210 23.396 24. .208 6. .943 1. .00 46. .03 C

ANISOU 1308 CA TYR A 210 5683 5960 5846 1351 406 -186 C

ATOM 1309 C TYR A 210 23.963 24. .997 5. .769 1. .00 44. .40 C

ANISOU 1309 C TYR A 210 5481 5649 5739 1213 253 -362 C

ATOM 1310 O TYR A 210 24.053 24. ,501 4. ,650 1. ,00 43. , 15 O

ANISOU 1310 O TYR A 210 5251 5392 5752 1092 198 -338 O

ATOM 1311 CB TYR A 210 24.409 23. .200 7. .450 1. .00 46. .65 C

ANISOU 1311 CB TYR A 210 5797 6120 5809 1421 378 -91 C

ATOM 1312 CG TYR A 210 25.549 23. .891 8. .142 1. .00 47. .40 c

ANISOU 1312 CG TYR A 210 5947 6424 5638 1499 244 -268 c

ATOM 1313 CD1 TYR A 210 25.388 24. .414 9. .426 1. .00 49. .38 c

ANISOU 1313 CD1 TYR A 210 6259 6879 5624 1648 298 -313 c

ATOM 1314 CD2 TYR A 210 26.782 24. .056 7. .512 1. .00 46. .54 c

ANISOU 1314 CD2 TYR A 210 5805 6350 5530 1401 72 -430 c

ATOM 1315 CE1 TYR A 210 26.432 25. .058 10. .071 1. .00 50. .64 c

ANISOU 1315 CE1 TYR A 210 6435 7287 5519 1683 168 -541 c

ATOM 1316 CE2 TYR A 210 27.825 24. .701 8. .146 1. .00 47. .80 c

ANISOU 1316 CE2 TYR A 210 5960 6756 5444 1424 -46 -647 c

ATOM 1317 CZ TYR A 210 27.643 25. .202 9. .421 1. .00 49. .90 c

ANISOU 1317 CZ TYR A 210 6279 7237 5445 1555 -5 -717 c

ATOM 1318 OH TYR A 210 28.672 25. .850 10. .050 1. .00 51. .67 0

ANISOU 1318 OH TYR A 210 6468 7755 5408 1542 -128 -995 0

ATOM 1319 N ARG A 211 24.350 26. .234 6. .070 1. .00 44. .87 N

ANISOU 1319 N ARG A 211 5645 5727 5677 1226 212 -549 N

ATOM 1320 CA ARG A 211 24.889 27. .165 5. .103 1. .00 44. .08 C

ANISOU 1320 CA ARG A 211 5606 5492 5649 1093 129 -708 c

ATOM 1321 C ARG A 211 26.060 27. ,894 5. ,720 1. ,00 45. , 13 c

ANISOU 1321 C ARG A 211 5831 5709 5608 1029 72 -947 c

ATOM 1322 O ARG A 211 26.005 28. .327 6. .867 1. .00 46. .84 0

ANISOU 1322 O ARG A 211 6109 6045 5643 1118 122 - 1047 0

ATOM 1323 CB ARG A 211 23.800 28. .144 4. .653 1. .00 44. .49 c

ANISOU 1323 CB ARG A 211 5715 5400 5789 1161 215 -698 c

ATOM 1324 CG ARG A 211 24.258 29. .287 3. .740 1. .00 44. .49 c

ANISOU 1324 CG ARG A 211 5857 5206 5843 1069 193 -821 c

ATOM 1325 CD ARG A 211 23.383 29. .420 2. .489 1. .00 44. .06 c

ANISOU 1325 CD ARG A 211 5753 5060 5927 1126 198 -678 c

ATOM 1326 NE ARG A 211 21.960 29. .158 2. .754 1. .00 44. .78 N

ANISOU 1326 NE ARG A 211 5710 5257 6046 1313 272 -541 N

ATOM 1327 CZ ARG A 211 21.031 28. .958 1. .816 1. .00 44. .83 C

ANISOU 1327 CZ ARG A 211 5564 5329 6142 1381 254 -422 C

ATOM 1328 NH1 ARG A 211 21.342 28. .976 0. .519 1. .00 44. .12 N

ANISOU 1328 NH1 ARG A 211 5459 5199 6105 1303 161 -400 N

ATOM 1329 NH2 ARG A 211 19.776 28. .732 2. .181 1. .00 45. .99 N

ANISOU 1329 NH2 ARG A 211 5542 5630 6302 1528 333 -339 N

ATOM 1330 N THR A 212 27.120 28. .016 4. .934 1. .00 44. .45 N

ANISOU 1330 N THR A 212 5731 5592 5566 854 -26 - 1064 N

ATOM 1331 CA THR A 212 28.401 28. .490 5. .425 1. .00 45. .77 C

ANISOU 1331 CA THR A 212 5902 5915 5574 733 -96 - 1326 C

ATOM 1332 C THR A 212 29.239 29. .107 4. .315 1. .00 45. .42 C

ANISOU 1332 C THR A 212 5885 5734 5639 486 -124 - 1476 C

ATOM 1333 O THR A 212 28.952 28. .908 3. .134 1. .00 43. .89 O

ANISOU 1333 O THR A 212 5689 5371 5615 447 -120 - 1335 O

ATOM 1334 CB THR A 212 29.210 27. .325 6. .019 1. .00 46. .09 C

ANISOU 1334 CB THR A 212 5784 6264 5463 830 -206 - 1275 C

ATOM 1335 OG1 THR A 212 30.556 27. ,758 6. ,246 1. ,00 47. , 56 O

ANISOU 1335 OG1 THR A 212 5895 6675 5500 689 -307 - 1560 O

ATOM 1336 CG2 THR A 212 29.192 26. .138 5. .067 1. .00 44. .25 C ANISOU 1336 CG2 THR A 212 5459 5950 5403 850 -240 -1055 C

ATOM 1337 N ARG A 213 30.276 29. .844 4. .715 1. .00 47. .27 N

ANISOU 1337 N ARG A 213 6129 6076 5756 306 -139 -1779 N

ATOM 1338 CA ARG A 213 31.296 30. .334 3. .809 1. .00 47. .59 C

ANISOU 1338 CA ARG A 213 6158 6050 5872 26 -143 -1951 C

ATOM 1339 C ARG A 213 32.532 29. .437 3. .836 1. .00 47. .65 C

ANISOU 1339 C ARG A 213 5908 6419 5779 -16 -301 -2028 C

ATOM 1340 O ARG A 213 33.351 29. .495 2. .914 1. .00 47. .51 O

ANISOU 1340 O ARG A 213 5818 6393 5839 -216 -314 -2109 O

ATOM 1341 CB ARG A 213 31.681 31. .772 4. .163 1. .00 50. .34 C

ANISOU 1341 CB ARG A 213 6673 6268 6185 -211 -15 -2284 C

ATOM 1342 N LYS A 214 32.671 28. .626 4. .887 1. .00 48. .29 N

ANISOU 1342 N LYS A 214 5851 6828 5668 201 -403 -1990 N

ATOM 1343 CA LYS A 214 33.711 27. .595 4. .900 1. .00 48. .58 C

ANISOU 1343 CA LYS A 214 5647 7210 5602 285 -547 -1980 C

ATOM 1344 C LYS A 214 33.113 26. .274 4. .371 1. .00 46. .37 C

ANISOU 1344 C LYS A 214 5363 6796 5459 512 -549 -1616 C

ATOM 1345 O LYS A 214 32.688 25. .412 5. .141 1. .00 46. .66 O

ANISOU 1345 O LYS A 214 5399 6927 5402 781 -551 -1413 O

ATOM 1346 CB LYS A 214 34.342 27. .452 6. .286 1. .00 51. .36 C

ANISOU 1346 CB LYS A 214 5851 8035 5628 430 -653 -2138 C

ATOM 1347 N ALA A 215 33.048 26. .160 3. .044 1. .00 44. .57 N

ANISOU 1347 N ALA A 215 5155 6333 5449 380 -520 -1547 N

ATOM 1348 CA ALA A 215 32.474 24. .998 2. .361 1. .00 42. .83 C

ANISOU 1348 CA ALA A 215 4933 5954 5387 513 -503 -1282 C

ATOM 1349 C ALA A 215 33.081 23. .680 2. .817 1. .00 43. .68 C

ANISOU 1349 C ALA A 215 4919 6274 5405 753 -562 -1169 C

ATOM 1350 O ALA A 215 32.398 22. .679 2. .831 1. .00 43. .19 O

ANISOU 1350 O ALA A 215 4911 6067 5433 914 -496 -936 O

ATOM 1351 CB ALA A 215 32.644 25. .138 0. .863 1. .00 41. .52 C

ANISOU 1351 CB ALA A 215 4764 5618 5394 319 -490 -1308 C

ATOM 1352 N VAL A 216 34.368 23. ,694 3. ,170 1. ,00 45. , 44 N

ANISOU 1352 N VAL A 216 4974 6841 5452 780 -668 -1342 N

ATOM 1353 CA VAL A 216 35.096 22. .521 3. .656 1. .00 47. .05 C

ANISOU 1353 CA VAL A 216 5051 7305 5521 1087 -730 -1231 C

ATOM 1354 C VAL A 216 34.260 21. .733 4. .656 1. .00 47. .74 C

ANISOU 1354 C VAL A 216 5271 7333 5535 1391 -652 -942 C

ATOM 1355 O VAL A 216 34.441 20. .530 4. .811 1. .00 48. .78 O

ANISOU 1355 O VAL A 216 5412 7467 5654 1672 -616 -725 O

ATOM 1356 CB VAL A 216 36.413 22. .936 4. .351 1. .00 49. .82 C

ANISOU 1356 CB VAL A 216 5167 8173 5587 1114 -874 -1492 C

ATOM 1357 CGI VAL A 216 37.138 24. .001 3. .545 1. .00 49. .73 c

ANISOU 1357 CGI VAL A 216 5044 8210 5643 719 -898 -1824 c

ATOM 1358 CG2 VAL A 216 36.149 23. .458 5. .757 1. .00 51. .68 c

ANISOU 1358 CG2 VAL A 216 5432 8646 5560 1214 -903 -1551 c

ATOM 1359 N ARG A 217 33.337 22. .433 5. .318 1. .00 47. .52 N

ANISOU 1359 N ARG A 217 5366 7228 5462 1338 -593 -936 N

ATOM 1360 CA ARG A 217 32.478 21. .855 6. .351 1. .00 48. .51 C

ANISOU 1360 CA ARG A 217 5617 7324 5492 1589 -486 -676 C

ATOM 1361 C ARG A 217 31.387 20. .921 5. .823 1. .00 47. .21 C

ANISOU 1361 C ARG A 217 5585 6758 5596 1605 -315 -400 C

ATOM 1362 O ARG A 217 30.866 20. .109 6. .560 1. .00 48. .58 O

ANISOU 1362 O ARG A 217 5858 6882 5719 1820 -185 -145 O

ATOM 1363 CB ARG A 217 31.845 22. ,980 7. ,175 1. ,00 48. , 95 c

ANISOU 1363 CB ARG A 217 5741 7443 5414 1511 -463 -803 c

ATOM 1364 CG ARG A 217 32.847 23. .765 8. .002 1. .00 51. .32 c

ANISOU 1364 CG ARG A 217 5915 8184 5398 1509 -604 -1099 c

ATOM 1365 CD ARG A 217 32.200 24. .895 8. .781 1. .00 52. .09 c

ANISOU 1365 CD ARG A 217 6114 8298 5379 1417 -551 -1268 c

ATOM 1366 NE ARG A 217 33.215 25. .682 9. .459 1. .00 54. .75 N

ANISOU 1366 NE ARG A 217 6313 9057 5432 1337 -680 -1637 N ATOM 1367 CZ ARG A 217 32.979 26..771 10..186 1..00 56..33 C

ANISOU 1367 CZ ARG A 217 6578 9337 5487 1220 -649 - 1906 C

ATOM 1368 NH1 ARG A 217 31.740 27. .238 10. .345 1. .00 55. .40 N

ANISOU 1368 NH1 ARG A 217 6668 8903 5479 1216 -490 - 1818 N

ATOM 1369 NH2 ARG A 217 34.002 27. .394 10. .760 1. .00 59. .28 N

ANISOU 1369 NH2 ARG A 217 6788 10135 5599 1106 -771 - 2295 N

ATOM 1370 N LEU A 218 31.048 21. .051 4. .546 1. .00 45. .02 N

ANISOU 1370 N LEU A 218 5303 6217 5587 1361 -300 -465 N

ATOM 1371 CA LEU A 218 30.016 20. .248 3. .909 1. .00 44. .13 C

ANISOU 1371 CA LEU A 218 5263 5773 5731 1303 -154 -294 C

ATOM 1372 C LEU A 218 30.639 19. ,253 2. ,922 1. ,00 43. , 99 C

ANISOU 1372 C LEU A 218 5211 5636 5869 1298 -154 -286 C

ATOM 1373 O LEU A 218 31.749 19. .468 2. .450 1. .00 43. .87 O

ANISOU 1373 O LEU A 218 5092 5779 5796 1279 -281 -442 O

ATOM 1374 CB LEU A 218 29.028 21. .171 3. .192 1. .00 42. .33 C

ANISOU 1374 CB LEU A 218 5038 5397 5650 1061 -143 -390 C

ATOM 1375 CG LEU A 218 28.074 21. .959 4. .079 1. .00 42. .75 C

ANISOU 1375 CG LEU A 218 5148 5482 5612 1095 -77 -363 C

ATOM 1376 CD1 LEU A 218 27.428 23. .088 3. .300 1. .00 41. .46 C

ANISOU 1376 CD1 LEU A 218 4985 5218 5548 923 -99 -485 C

ATOM 1377 CD2 LEU A 218 27.019 21. .032 4. .649 1. .00 43. .80 C

ANISOU 1377 CD2 LEU A 218 5326 5506 5809 1190 108 -130 C

ATOM 1378 N PRO A 219 29.913 18. ,181 2. ,564 1. ,00 44. , 34 N

ANISOU 1378 N PRO A 219 5331 5396 6119 1286 10 -138 N

ATOM 1379 CA PRO A 219 28.513 17. .909 2. .846 1. .00 44. .64 C

ANISOU 1379 CA PRO A 219 5442 5239 6280 1211 187 -2 C

ATOM 1380 C PRO A 219 28.280 17. .132 4. .122 1. .00 47. .13 C

ANISOU 1380 C PRO A 219 5891 5522 6495 1454 366 263 C

ATOM 1381 O PRO A 219 29.227 16. .705 4. .795 1. .00 48. .85 O

ANISOU 1381 O PRO A 219 6160 5874 6527 1739 345 372 O

ATOM 1382 CB PRO A 219 28.102 17. .044 1. .660 1. .00 44. .45 C

ANISOU 1382 CB PRO A 219 5407 4948 6535 1023 281 -47 C

ATOM 1383 CG PRO A 219 29.329 16. .255 1. .370 1. .00 45. .36 C

ANISOU 1383 CG PRO A 219 5553 5039 6644 1177 259 -51 c

ATOM 1384 CD PRO A 219 30.513 17. .097 1. .766 1. .00 44. .94 c

ANISOU 1384 CD PRO A 219 5415 5325 6337 1322 53 -136 c

ATOM 1385 N ILE A 220 26.996 16. .961 4. .412 1. .00 47. .68 N

ANISOU 1385 N ILE A 220 6001 5443 6673 1350 551 369 N

ATOM 1386 CA ILE A 220 26.499 16. .113 5. .482 1. .00 50. .43 C

ANISOU 1386 CA ILE A 220 6501 5681 6980 1513 806 651 C

ATOM 1387 C ILE A 220 26.640 14. .649 5. .101 1. .00 52. .45 C

ANISOU 1387 C ILE A 220 6896 5589 7445 1531 1021 787 C

ATOM 1388 O ILE A 220 26.096 14. .165 4. .103 1. .00 52. .17 O

ANISOU 1388 O ILE A 220 6822 5302 7696 1253 1113 668 O

ATOM 1389 CB ILE A 220 25.018 16. .390 5. .789 1. .00 50. .70 c

ANISOU 1389 CB ILE A 220 6496 5669 7098 1336 970 688 c

ATOM 1390 CGI ILE A 220 24.863 17. .772 6. .439 1. .00 49. .62 c

ANISOU 1390 CGI ILE A 220 6287 5840 6724 1404 821 595 c

ATOM 1391 CG2 ILE A 220 24.434 15. .268 6. .647 1. .00 54. .04 c

ANISOU 1391 CG2 ILE A 220 7089 5885 7557 1419 1316 986 c

ATOM 1392 CD1 ILE A 220 23.519 18. .424 6. .204 1. .00 48. .95 c

ANISOU 1392 CD1 ILE A 220 6078 5764 6757 1207 878 509 c

ATOM 1393 N VAL A 221 27.368 13. .944 5. .940 1. .00 55. .03 N

ANISOU 1393 N VAL A 221 7391 5915 7605 1882 1114 1032 N

ATOM 1394 CA VAL A 221 27.722 12. .564 5. .691 1. .00 57. .64 C

ANISOU 1394 CA VAL A 221 7913 5888 8101 2002 1337 1192 C

ATOM 1395 C VAL A 221 26.987 11. .616 6. .638 1. ,00 61. , 44 C

ANISOU 1395 C VAL A 221 8649 6084 8611 2108 1731 1544 C

ATOM 1396 O VAL A 221 26.758 10. .461 6. .296 1. .00 63. .92 0

ANISOU 1396 O VAL A 221 9152 5947 9186 2038 2030 1644 0

ATOM 1397 CB VAL A 221 29.238 12. .374 5. .867 1. .00 58. .61 c ANISOU 1397 CB VAL A 221 8051 6219 7998 2409 1172 1246 C

ATOM 1398 CGI VAL A 221 29.993 13. .256 4. .878 1. .00 55. .33 C

ANISOU 1398 CGI VAL A 221 7385 6062 7577 2255 835 893 C

ATOM 1399 CG2 VAL A 221 29.668 12. .684 7. .304 1. .00 60. .55 C

ANISOU 1399 CG2 VAL A 221 8337 6842 7828 2812 1115 1471 C

ATOM 1400 N ASP A 222 26.617 12. .117 7. .822 1. .00 62. .25 N

ANISOU 1400 N ASP A 222 8772 6437 8445 2260 1757 1718 N

ATOM 1401 CA ASP A 222 25.975 11. .309 8. .870 1. .00 66. .28 C

ANISOU 1401 CA ASP A 222 9536 6737 8910 2402 2148 2098 C

ATOM 1402 C ASP A 222 24.981 12. .099 9. .723 1. .00 66. .04 C

ANISOU 1402 C ASP A 222 9421 6951 8721 2307 2193 2130 C

ATOM 1403 O ASP A 222 25.133 13. .310 9. .895 1. .00 63. .45 O

ANISOU 1403 O ASP A 222 8895 7035 8179 2321 1889 1929 O

ATOM 1404 CB ASP A 222 27.043 10. .726 9. .793 1. .00 69. .68 C

ANISOU 1404 CB ASP A 222 10184 7276 9014 2978 2186 2440 C

ATOM 1405 CG ASP A 222 26.650 9. .377 10. .377 1. .00 74. .78 C

ANISOU 1405 CG ASP A 222 11207 7456 9751 3142 2684 2873 c

ATOM 1406 OD1 ASP A 222 25.443 9. ,059 10. ,391 1. ,00 75. ,86 0

ANISOU 1406 OD1 ASP A 222 11414 7274 10135 2788 3012 2918 0

ATOM 1407 OD2 ASP A 222 27.557 8. .633 10. .816 1. .00 78. .16 0

ANISOU 1407 OD2 ASP A 222 11858 7840 9997 3634 2764 3173 0

ATOM 1408 N ILE A 223 24.006 11. .380 10. .291 1. .00 69. .29 N

ANISOU 1408 N ILE A 223 10003 7091 9234 2221 2608 2386 N

ATOM 1409 CA ILE A 223 22.894 11. .956 11. .069 1. .00 69. .78 C

ANISOU 1409 CA ILE A 223 9983 7340 9189 2100 2738 2431 C

ATOM 1410 C ILE A 223 22.627 11. .204 12. .376 1. .00 74. .69 C

ANISOU 1410 C ILE A 223 10899 7873 9605 2371 3138 2893 C

ATOM 1411 O ILE A 223 22.682 9. .991 12. .406 1. .00 78. .24 O

ANISOU 1411 O ILE A 223 11630 7889 10211 2424 3488 3166 0

ATOM 1412 CB ILE A 223 21.588 11. .965 10. .249 1. .00 68. .91 c

ANISOU 1412 CB ILE A 223 9677 7032 9473 1564 2886 2199 c

ATOM 1413 CGI ILE A 223 20.456 12. .623 11. .046 1. .00 69. .58 c

ANISOU 1413 CGI ILE A 223 9634 7370 9435 1477 3011 2228 c

ATOM 1414 CG2 ILE A 223 21.201 10. .549 9. .838 1. .00 72. .32 c

ANISOU 1414 CG2 ILE A 223 10301 6910 10268 1329 3305 2321 c

ATOM 1415 CD1 ILE A 223 19.247 13. .004 10. .220 1. .00 68. .25 c

ANISOU 1415 CD1 ILE A 223 9151 7215 9566 1019 3024 1926 c

ATOM 1416 N ALA A 224 22.298 11. .936 13. .439 1. .00 75. .23 N

ANISOU 1416 N ALA A 224 10924 8335 9327 2536 3115 2975 N

ATOM 1417 CA ALA A 224 22.144 11. .373 14. .796 1. .00 80. .08 C

ANISOU 1417 CA ALA A 224 11815 8982 9630 2867 3459 3433 C

ATOM 1418 C ALA A 224 20.854 11. .756 15. .527 1. .00 81. .48 C

ANISOU 1418 C ALA A 224 11918 9293 9747 2684 3717 3483 C

ATOM 1419 O ALA A 224 20.822 12. .753 16. .210 1. .00 80. .55 0

ANISOU 1419 O ALA A 224 11674 9645 9288 2842 3522 3384 0

ATOM 1420 CB ALA A 224 23.326 11. .775 15. .661 1. .00 80. .82 c

ANISOU 1420 CB ALA A 224 11967 9556 9184 3423 3175 3549 c

ATOM 1421 N PRO A 225 19.801 10. .942 15. .432 1. ,00 84. , 27 N

ANISOU 1421 N PRO A 225 12352 9244 10421 2351 4186 3626 N

ATOM 1422 CA PRO A 225 18.570 11. .285 16. .157 1. .00 86. .08 C

ANISOU 1422 CA PRO A 225 12476 9648 10581 2184 4458 3675 C

ATOM 1423 C PRO A 225 18.606 10. .970 17. .655 1. .00 90. .86 C

ANISOU 1423 C PRO A 225 13374 10414 10735 2596 4762 4146 C

ATOM 1424 O PRO A 225 18.840 9. .834 18. .035 1. .00 95. .25 O

ANISOU 1424 O PRO A 225 14292 10615 11283 2765 5135 4569 0

ATOM 1425 CB PRO A 225 17.514 10. .415 15. .475 1. .00 88. .09 c

ANISOU 1425 CB PRO A 225 12694 9421 11353 1643 4878 3640 c

ATOM 1426 CG PRO A 225 18.279 9. .292 14. .868 1. .00 89. .40 c

ANISOU 1426 CG PRO A 225 13143 9071 11756 1668 4989 3770 c

ATOM 1427 CD PRO A 225 19.579 9. .889 14. .433 1. .00 85. .24 c

ANISOU 1427 CD PRO A 225 12559 8785 11044 1995 4436 3594 c ATOM 1428 N TYR A 226 18.378 11..982 18..488 1..00 90..36 N

ANISOU 1428 N TYR A 226 13171 10877 10284 2774 4615 4072 N

ATOM 1429 CA TYR A 226 18.312 11. .804 19. .945 1. .00 95. .08 C

ANISOU 1429 CA TYR A 226 14008 11727 10391 3160 4893 4483 C

ATOM 1430 C TYR A 226 17.104 10. .990 20. .421 1. .00 99. .95 C

ANISOU 1430 C TYR A 226 14761 12050 11167 2911 5543 4804 C

ATOM 1431 O TYR A 226 17.230 10. .131 21. .283 1. .00105. .18 O

ANISOU 1431 O TYR A 226 15792 12575 11598 3191 5939 5310 O

ATOM 1432 CB TYR A 226 18.325 13. .155 20. .660 1. .00 93. .45 C

ANISOU 1432 CB TYR A 226 13597 12168 9743 3367 4575 4237 C

ATOM 1433 N ASP A 227 15.923 11. .269 19. .896 1. .00 98. .80 N

ANISOU 1433 N ASP A 227 14310 11838 11391 2399 5675 4524 N

ATOM 1434 CA ASP A 227 14.755 10. .527 20. .334 1. .00103. .80 C

ANISOU 1434 CA ASP A 227 15015 12235 12189 2100 6310 4779 C

ATOM 1435 C ASP A 227 14.470 9. .416 19. .349 1. .00105. .10 C

ANISOU 1435 C ASP A 227 15250 11750 12936 1631 6613 4771 C

ATOM 1436 O ASP A 227 13.966 9. .667 18. .258 1. .00102. .09 O

ANISOU 1436 O ASP A 227 14516 11304 12968 1177 6453 4338 O

ATOM 1437 CB ASP A 227 13.545 11. .446 20. .449 1. .00102. .92 C

ANISOU 1437 CB ASP A 227 14488 12509 12108 1825 6329 4474 C

ATOM 1438 CG ASP A 227 12.302 10. .714 20. .919 1. , 00108. ,49 C

ANISOU 1438 CG ASP A 227 15205 13037 12978 1477 7005 4706 c

ATOM 1439 OD1 ASP A 227 12.290 10. .248 22. .075 1. .00113. .40 0

ANISOU 1439 OD1 ASP A 227 16151 13681 13253 1746 7402 5170 0

ATOM 1440 OD2 ASP A 227 11.339 10. .590 20. .139 1. .00108. .42 0

ANISOU 1440 OD2 ASP A 227 14871 12895 13427 932 7153 4425 0

ATOM 1441 N ILE A 228 14.819 8. .189 19. .713 1. .00109. .97 N

ANISOU 1441 N ILE A 228 16331 11884 13570 1761 7052 5239 N

ATOM 1442 CA ILE A 228 14.704 7. .074 18. .765 1. .00111. .68 C

ANISOU 1442 CA ILE A 228 16683 11408 14343 1337 7354 5209 C

ATOM 1443 C ILE A 228 14.601 5. .714 19. .440 1. .00119. .15 C

ANISOU 1443 C ILE A 228 18167 11775 15329 1385 8078 5785 C

ATOM 1444 O ILE A 228 14.927 5. .564 20. .620 1. .00122. .77 O

ANISOU 1444 O ILE A 228 18962 12371 15313 1896 8275 6286 0

ATOM 1445 CB ILE A 228 15.887 7. .039 17. .773 1. .00107. .51 c

ANISOU 1445 CB ILE A 228 16189 10719 13940 1500 6878 5004 c

ATOM 1446 N GLY A 229 14.141 4. .725 18. .678 1. .00121. .89 N

ANISOU 1446 N GLY A 229 18607 11472 16235 849 8492 5701 N

ATOM 1447 CA GLY A 229 14.083 3. .353 19. .155 1. .00129. .43 C

ANISOU 1447 CA GLY A 229 20135 11723 17322 841 9235 6223 C

ATOM 1448 C GLY A 229 12.864 2. .986 19. .969 1. .00135. .50 C

ANISOU 1448 C GLY A 229 20956 12404 18124 489 9931 6471 C

ATOM 1449 O GLY A 229 12.775 1. .870 20. .478 1. , 00142. , 53 O

ANISOU 1449 O GLY A 229 22370 12690 19094 490 10620 6961 O

ATOM 1450 N GLY A 230 11.918 3. .914 20. .100 1. .00133. .28 N

ANISOU 1450 N GLY A 230 20149 12711 17783 200 9788 6148 N

ATOM 1451 CA GLY A 230 10.693 3. .608 20. .797 1. .00139. .07 C

ANISOU 1451 CA GLY A 230 20845 13421 18573 -193 10449 6318 C

ATOM 1452 C GLY A 230 9.991 2. .582 19. .945 1. .00142. .99 C

ANISOU 1452 C GLY A 230 21338 13242 19751 -986 10966 6097 C

ATOM 1453 O GLY A 230 10.114 2. .608 18. .727 1. .00139. .31 O

ANISOU 1453 O GLY A 230 20609 12652 19671 -1317 10630 5596 O

ATOM 1454 N PRO A 231 9.236 1. .679 20. .573 1. .00150. .90 N

ANISOU 1454 N PRO A 231 22623 13814 20897 -1323 11807 6445 N

ATOM 1455 CA PRO A 231 8.556 0. .654 19. .801 1. .00155. .62 C

ANISOU 1455 CA PRO A 231 23233 13733 22161 -2145 12365 6198 C

ATOM 1456 C PRO A 231 7.635 1. .393 18. .852 1. .00151. .62 C

ANISOU 1456 C PRO A 231 21899 13750 21960 -2777 11997 5424 C

ATOM 1457 O PRO A 231 7.487 1. .023 17. .689 1. .00151. .02 O

ANISOU 1457 O PRO A 231 21616 13390 22373 -3316 11934 4933 O

ATOM 1458 CB PRO A 231 7.731 -0. ,063 20. ,854 1. , 00164. ,41 C ANISOU 1458 CB PRO A 231 24656 14556 23257 -2384 13284 6679 C

ATOM 1459 CG PRO A 231 7.371 1. .017 21. .815 1. .00162. .35 C

ANISOU 1459 CG PRO A 231 24083 15164 22439 -2011 13051 6799 C

ATOM 1460 CD PRO A 231 8.530 1. .974 21. .827 1. .00154. .67 C

ANISOU 1460 CD PRO A 231 23087 14694 20987 -1204 12179 6794 C

ATOM 1461 N ASP A 232 7.042 2. ,460 19. , 373 1. , 00149. ,19 N

ANISOU 1461 N ASP A 232 21125 14241 21321 -2653 11746 5324 N

ATOM 1462 CA ASP A 232 6.228 3. .353 18. .588 1. .00145. .16 C

ANISOU 1462 CA ASP A 232 19815 14361 20978 -3059 11318 4653 C

ATOM 1463 C ASP A 232 7.046 4. .039 17. .503 1. .00137. .16 C

ANISOU 1463 C ASP A 232 18584 13551 19981 -2818 10475 4242 C

ATOM 1464 O ASP A 232 6.567 4. .229 16. .391 1. .00135. .16 O

ANISOU 1464 O ASP A 232 17827 13457 20071 -3298 10225 3662 O

ATOM 1465 CB ASP A 232 5.583 4. .406 19. .493 1. .00144. .32 C

ANISOU 1465 CB ASP A 232 19348 15045 20441 -2803 11217 4708 C

ATOM 1466 N GLN A 233 8.283 4. .390 17. .825 1. .00133. .11 N

ANISOU 1466 N GLN A 233 18441 13056 19079 -2080 10054 4541 N

ATOM 1467 CA GLN A 233 9.097 5. .298 17. .006 1. .00125. .23 C

ANISOU 1467 CA GLN A 233 17215 12390 17977 -1756 9222 4197 C

ATOM 1468 C GLN A 233 9.614 4. .819 15. .627 1. .00122. .96 C

ANISOU 1468 C GLN A 233 16921 11693 18106 -2031 8986 3833 C

ATOM 1469 O GLN A 233 10.380 3. .865 15. .550 1. .00125. .20 O

ANISOU 1469 O GLN A 233 17721 11340 18509 -1921 9214 4091 O

ATOM 1470 CB GLN A 233 10.282 5. .763 17. .849 1. .00122. .57 C

ANISOU 1470 CB GLN A 233 17264 12224 17082 -918 8897 4617 C

ATOM 1471 N GLU A 234 9.230 5. .521 14. .557 1. .00118. .69 N

ANISOU 1471 N GLU A 234 15805 11549 17744 -2323 8517 3249 N

ATOM 1472 CA GLU A 234 9.717 5. .209 13. .207 1. .00116. .18 C

ANISOU 1472 CA GLU A 234 15428 10960 17757 -2555 8227 2860 C

ATOM 1473 C GLU A 234 10.123 6. .461 12. .411 1. .00108. .68 C

ANISOU 1473 C GLU A 234 14074 10578 16640 -2297 7422 2485 C

ATOM 1474 O GLU A 234 9.511 7. .521 12. .553 1. .00106. .38 O

ANISOU 1474 O GLU A 234 13347 10909 16162 -2231 7156 2317 O

ATOM 1475 CB GLU A 234 8.673 4. .395 12. .440 1. .00120. .97 C

ANISOU 1475 CB GLU A 234 15759 11319 18886 -3400 8649 2457 C

ATOM 1476 N PHE A 235 11.148 6. .330 11. .567 1. .00105. .31 N

ANISOU 1476 N PHE A 235 13810 9917 16286 -2145 7069 2362 N

ATOM 1477 CA PHE A 235 11.660 7. .458 10. .778 1. .00 98. .57 C

ANISOU 1477 CA PHE A 235 12650 9525 15278 -1896 6348 2048 C

ATOM 1478 C PHE A 235 12.279 7. ,082 9. , 426 1. ,00 96. , 51 C

ANISOU 1478 C PHE A 235 12383 9006 15281 -2074 6092 1712 C

ATOM 1479 O PHE A 235 12.781 5. .969 9. .232 1. .00 99. .35 O

ANISOU 1479 O PHE A 235 13129 8758 15862 -2172 6392 1816 O

ATOM 1480 CB PHE A 235 12.665 8. .267 11. .603 1. .00 94. .88 C

ANISOU 1480 CB PHE A 235 12422 9294 14333 -1184 6003 2375 C

ATOM 1481 CG PHE A 235 14.067 7. .749 11. .532 1. .00 93. .86 c

ANISOU 1481 CG PHE A 235 12752 8778 14131 -806 5893 2599 c

ATOM 1482 CD1 PHE A 235 14.918 8. .130 10. .493 1. .00 89. .18 c

ANISOU 1482 CD1 PHE A 235 12068 8243 13572 -705 5390 2319 c

ATOM 1483 CD2 PHE A 235 14.538 6. .878 12. .501 1. .00 98. .02 c

ANISOU 1483 CD2 PHE A 235 13798 8908 14538 -522 6307 3107 c

ATOM 1484 CE1 PHE A 235 16.210 7. .642 10. .426 1. .00 88. .62 c

ANISOU 1484 CE1 PHE A 235 12378 7862 13431 -344 5299 2511 c

ATOM 1485 CE2 PHE A 235 15.834 6. .394 12. .445 1. .00 97. .60 c

ANISOU 1485 CE2 PHE A 235 14141 8548 14396 -109 6202 3324 c

ATOM 1486 CZ PHE A 235 16.670 6. .773 11. .404 1. .00 92. .86 c

ANISOU 1486 CZ PHE A 235 13406 8031 13846 -29 5695 3009 c

ATOM 1487 N GLY A 236 12.227 8. .038 8. .503 1. .00 91. .90 N

ANISOU 1487 N GLY A 236 11374 8889 14657 -2086 5556 1321 N

ATOM 1488 CA GLY A 236 12.979 7. .966 7. .251 1. .00 88. .91 C

ANISOU 1488 CA GLY A 236 10977 8397 14406 -2122 5200 1024 C ATOM 1489 C GLY A 236 13.715 9.,280 7., 042 1.,00 82.,71 C

ANISOU 1489 C GLY A 236 10074 8057 13293 -1650 4578 987 C

ATOM 1490 O GLY A 236 13.546 10. .215 7. .814 1. .00 81. .07 O

ANISOU 1490 O GLY A 236 9782 8224 12799 -1351 4442 1137 O

ATOM 1491 N VAL A 237 14.539 9. .339 6. .006 1. .00 79. .67 N

ANISOU 1491 N VAL A 237 9703 7612 12957 -1600 4237 776 N

ATOM 1492 CA VAL A 237 15.290 10. .531 5. .636 1. .00 74. .22 C

ANISOU 1492 CA VAL A 237 8912 7286 12003 -1228 3681 702 C

ATOM 1493 C VAL A 237 15.263 10. .531 4. .113 1. .00 72. .83 C

ANISOU 1493 C VAL A 237 8473 7188 12012 -1518 3427 273 C

ATOM 1494 O VAL A 237 15.077 9. .475 3. .485 1. .00 75. .82 O

ANISOU 1494 O VAL A 237 8880 7242 12686 -1900 3669 87 O

ATOM 1495 CB VAL A 237 16.775 10. .453 6. .105 1. .00 72. .37 C

ANISOU 1495 CB VAL A 237 9097 6837 11561 -745 3555 995 C

ATOM 1496 CGI VAL A 237 17.576 11. .719 5. .769 1. .00 67. .22 c

ANISOU 1496 CGI VAL A 237 8337 6559 10647 -419 3020 893 c

ATOM 1497 CG2 VAL A 237 16.866 10. .147 7. .592 1. .00 75. .01 c

ANISOU 1497 CG2 VAL A 237 9746 7050 11703 -457 3869 1442 c

ATOM 1498 N ASP A 238 15.398 11. .724 3. .536 1. .00 68. .83 N

ANISOU 1498 N ASP A 238 7719 7111 11323 -1344 2971 109 N

ATOM 1499 CA ASP A 238 15.808 11. .918 2. .150 1. .00 66. .60 C

ANISOU 1499 CA ASP A 238 7288 6928 11090 -1434 2642 -205 C

ATOM 1500 C ASP A 238 16.878 13. .013 2. .226 1. .00 62. .02 C

ANISOU 1500 C ASP A 238 6831 6513 10222 -978 2251 -82 C

ATOM 1501 O ASP A 238 16.739 13. .955 2. .998 1. .00 60. .67 O

ANISOU 1501 O ASP A 238 6637 6583 9834 -718 2157 70 O

ATOM 1502 CB ASP A 238 14.614 12. .348 1. .282 1. .00 67. .50 c

ANISOU 1502 CB ASP A 238 6901 7484 11264 -1735 2521 -554 c

ATOM 1503 N VAL A 239 17.941 12. ,889 1. , 449 1. ,00 60. , 05 N

ANISOU 1503 N VAL A 239 6710 6135 9972 -901 2051 -170 N

ATOM 1504 CA VAL A 239 19.072 13. .790 1. .587 1. .00 56. .42 C

ANISOU 1504 CA VAL A 239 6386 5789 9263 -520 1742 -60 C

ATOM 1505 C VAL A 239 19.135 14. .741 0. .402 1. .00 53. .77 C

ANISOU 1505 C VAL A 239 5820 5757 8853 -540 1385 -307 C

ATOM 1506 O VAL A 239 19.398 14. .302 -0. ,713 1. ,00 53. , 78 O

ANISOU 1506 O VAL A 239 5766 5702 8965 -714 1311 -520 O

ATOM 1507 CB VAL A 239 20.370 12. .958 1. .649 1. .00 56. .55 c

ANISOU 1507 CB VAL A 239 6725 5459 9304 -363 1797 58 c

ATOM 1508 CGI VAL A 239 21.571 13. .822 1. .995 1. .00 53. .58 c

ANISOU 1508 CGI VAL A 239 6462 5243 8655 15 1516 170 c

ATOM 1509 CG2 VAL A 239 20.226 11. .818 2. .651 1. .00 60. .23 c

ANISOU 1509 CG2 VAL A 239 7454 5559 9872 -349 2212 321 c

ATOM 1510 N GLY A 240 18.903 16. .034 0. .634 1. .00 51. .91 N

ANISOU 1510 N GLY A 240 5477 5826 8420 -348 1189 -273 N

ATOM 1511 CA GLY A 240 19.026 17. .034 -0. , 429 1. ,00 49. , 77 C

ANISOU 1511 CA GLY A 240 5054 5808 8047 -302 881 -439 C

ATOM 1512 C GLY A 240 20.466 17. .246 -0. ,861 1. ,00 47. , 37 C

ANISOU 1512 C GLY A 240 4944 5400 7655 -165 692 -443 C

ATOM 1513 O GLY A 240 21.394 16. .952 -0. ,099 1. ,00 46. , 98 O

ANISOU 1513 O GLY A 240 5124 5173 7554 -9 744 -294 0

ATOM 1514 N PRO A 241 20.661 17. .771 -2. , 086 1. ,00 46. , 15 N

ANISOU 1514 N PRO A 241 4679 5400 7456 -204 476 -609 N

ATOM 1515 CA PRO A 241 22.007 17. .958 -2. , 634 1. ,00 44. , 25 C

ANISOU 1515 CA PRO A 241 4583 5089 7139 -120 319 -642 C

ATOM 1516 C PRO A 241 22.841 18. .972 -1. , 870 1. ,00 42. , 48 C

ANISOU 1516 C PRO A 241 4521 4888 6731 123 220 -512 C

ATOM 1517 O PRO A 241 22.289 19. .876 -1. , 239 1. ,00 42. , 36 O

ANISOU 1517 O PRO A 241 4493 4985 6618 239 213 -437 O

ATOM 1518 CB PRO A 241 21.746 18. .474 -4. , 049 1. ,00 43. , 91 C

ANISOU 1518 CB PRO A 241 4366 5269 7048 -208 140 -819 c

ATOM 1519 CG PRO A 241 20.392 19. .088 -3. , 997 1. ,00 45. , 03 c ANISOU 1519 CG PRO A 241 4297 5661 7152 -194 134 -816 C

ATOM 1520 CD PRO A 241 19.618 18. .275 -3. .001 1. .00 46. .92 C

ANISOU 1520 CD PRO A 241 4493 5799 7533 -297 371 -760 C

ATOM 1521 N VAL A 242 24.159 18. .803 -1. .926 1. .00 41. .55 N

ANISOU 1521 N VAL A 242 4537 4682 6567 191 157 -516 N

ATOM 1522 CA VAL A 242 25.086 19. .790 -1. .388 1. .00 40. .28 C

ANISOU 1522 CA VAL A 242 4484 4594 6227 354 45 -477 C

ATOM 1523 C VAL A 242 25.406 20. .809 -2. .475 1. .00 39. .07 C

ANISOU 1523 C VAL A 242 4296 4545 6004 302 -112 -593 C

ATOM 1524 O VAL A 242 25.920 20. .465 -3. .540 1. .00 38. .79 O

ANISOU 1524 O VAL A 242 4223 4510 6006 204 -170 -697 O

ATOM 1525 CB VAL A 242 26.376 19. .155 -0. .844 1. .00 40. .50 C

ANISOU 1525 CB VAL A 242 4624 4559 6207 473 54 -433 C

ATOM 1526 CGI VAL A 242 27.009 18. .231 -1. .874 1. .00 40. .69 c

ANISOU 1526 CGI VAL A 242 4627 4486 6346 387 50 -534 c

ATOM 1527 CG2 VAL A 242 27.349 20. .237 -0. .400 1. .00 39. .68 c

ANISOU 1527 CG2 VAL A 242 4564 4605 5907 575 -77 -474 c

ATOM 1528 N CYS A 243 25.096 22. .067 -2. .201 1. .00 38. .76 N

ANISOU 1528 N CYS A 243 4293 4575 5857 379 -152 -568 N

ATOM 1529 CA CYS A 243 25.124 23. .064 -3. .241 1. .00 38. .34 C

ANISOU 1529 CA CYS A 243 4245 4580 5745 353 -243 -622 C

ATOM 1530 C CYS A 243 26.220 24. .066 -3. .021 1. .00 37. .86 C

ANISOU 1530 C CYS A 243 4331 4483 5571 370 -281 -664 C

ATOM 1531 O CYS A 243 26.295 24. .710 -1. .974 1. .00 38. .16 O

ANISOU 1531 O CYS A 243 4464 4499 5538 450 -244 -652 O

ATOM 1532 CB CYS A 243 23.787 23. .762 -3. .319 1. .00 39. .19 c

ANISOU 1532 CB CYS A 243 4288 4770 5832 443 -223 -561 c

ATOM 1533 SG CYS A 243 22.502 22. .695 -3. .971 1. .00 40. .45 s

ANISOU 1533 SG CYS A 243 4184 5073 6110 341 -201 -599 s

ATOM 1534 N PHE A 244 27.073 24. .188 -4. .035 1. .00 37. .49 N

ANISOU 1534 N PHE A 244 4294 4446 5504 269 -338 -740 N

ATOM 1535 CA PHE A 244 28.227 25. .078 -3. .983 1. .00 37. .51 C

ANISOU 1535 CA PHE A 244 4407 4425 5420 207 -346 -820 C

ATOM 1536 C PHE A 244 28.005 26. .289 -4. .848 1. .00 38. .09 C

ANISOU 1536 C PHE A 244 4596 4436 5441 188 -319 -790 C

ATOM 1537 O PHE A 244 27.490 26. .170 -5. .954 1. .00 38. .26 O

ANISOU 1537 O PHE A 244 4568 4509 5459 198 -346 -737 0

ATOM 1538 CB PHE A 244 29.497 24. .363 -4. .438 1. .00 37. .23 c

ANISOU 1538 CB PHE A 244 4298 4458 5389 107 -390 -924 c

ATOM 1539 CG PHE A 244 29.831 23. .165 -3. .613 1. .00 37. .27 c

ANISOU 1539 CG PHE A 244 4228 4503 5430 192 -395 -918 c

ATOM 1540 CD1 PHE A 244 30.528 23. .294 -2. .433 1. .00 37. .83 c

ANISOU 1540 CD1 PHE A 244 4312 4656 5407 267 -405 -948 c

ATOM 1541 CD2 PHE A 244 29.419 21. .906 -4. .002 1. .00 37. .29 c

ANISOU 1541 CD2 PHE A 244 4161 4462 5546 209 -372 -883 c

ATOM 1542 CE1 PHE A 244 30.825 22. .192 -1. .665 1. .00 38. .42 c

ANISOU 1542 CE1 PHE A 244 4342 4780 5476 416 -397 -888 c

ATOM 1543 CE2 PHE A 244 29.710 20. .794 -3. .235 1. .00 37. .92 c

ANISOU 1543 CE2 PHE A 244 4232 4511 5666 323 -327 -834 c

ATOM 1544 CZ PHE A 244 30.425 20. .942 -2. .066 1. .00 38. .49 c

ANISOU 1544 CZ PHE A 244 4329 4678 5618 457 -342 -808 c

ATOM 1545 N LEU A 245 28.419 27. ,446 -4. .338 1. .00 38. .88 N

ANISOU 1545 N LEU A 245 4860 4426 5485 164 -249 -832 N

ATOM 1546 CA LEU A 245 28.342 28. .700 -5. .092 1. .00 40. .11 C

ANISOU 1546 CA LEU A 245 5205 4439 5597 153 -160 -781 c

ATOM 1547 C LEU A 245 29.660 29. .471 -4. .987 1. .00 41. .07 c

ANISOU 1547 C LEU A 245 5450 4465 5690 -64 -76 -934 c

ATOM 1548 O LEU A 245 29.827 30. .366 -4. .139 1. .00 42. .29 0

ANISOU 1548 O LEU A 245 5753 4484 5833 -104 19 - 1028 0

ATOM 1549 CB LEU A 245 27.154 29. .562 -4. .633 1. .00 41. .21 c

ANISOU 1549 CB LEU A 245 5476 4458 5725 362 -83 -666 c ATOM 1550 CG LEU A 245 26.992 30..943 -5..291 1..00 43.25 c

ANISOU 1550 CG LEU A 245 5998 4498 5935 431 58 -567 c

ATOM 1551 CD1 LEU A 245 26.731 30. .875 -6. .804 1. .00 43 .73 c

ANISOU 1551 CD1 LEU A 245 6037 4648 5930 497 25 -413 c

ATOM 1552 CD2 LEU A 245 25.898 31. .723 -4. .588 1. .00 44 .63 c

ANISOU 1552 CD2 LEU A 245 6299 4550 6106 683 148 -483 c

ATOM 1553 OXT LEU A 245 30.598 29. .189 -5. .755 1. .00 40 .98 0

ANISOU 1553 OXT LEU A 245 5372 4530 5667 -226 -90 - 1000 0

TER 1554 LEU A 245

HETATM 1555 CA CA A 246 38.834 16. ,226 -14. .606 1. .00 46 .98 CA

ANISOU 1555 CA CA A 246 4546 6721 6584 -28 -96 - 2494 CA

HETATM 1556 O HOH A2001 40.870 15. .223 -13. .896 1. .00 60 .96 O

ANISOU 1556 O HOH A2001 6085 8691 8388 383 -18 - 2599 O

CONECT 179 399

CONECT 304 1555

CONECT 305 1555

CONECT 319 1555

CONECT 324 1555

CONECT 337 1555

CONECT 356 1555

CONECT 399 179

CONECT 457 1533

CONECT 933 1216

CONECT 1216 933

CONECT 1533 457

CONECT 1555 304 305 319 324

CONECT 1555 337 356 1556

CONECT 1556 1555

MASTER 447 0 1 5 17 0 2 6 1555 1 15 20

END

Table C. Atomic coordinates of the crystal of form III

HEADER STRUCTURAL PROTEIN 4AEJ

TITLE CRYSTAL STRUCTURE OF HUMAN FIBRILLAR PROCOLLAGEN TYPE III C-

TITLE 2 PROPEPTIDE TRIMER

COMPND MOL ID: 1;

COMPND 2 MOLECULE: COLLAGEN ALPHA-1 (III) CHAIN;

COMPND 3 CHAIN: A, B;

COMPND 4 FRAGMENT: CPROPEPTIDE OF PROCOLLAGEN III, RESIDUES 919-1163;

COMPND 5 SYNONYM: PROCOLLAGEN III;

COMPND 6 ENGINEERED: YES;

COMPND 7 MUTATION: YES;

COMPND 8 MOL ID: 2;

COMPND 9 MOLECULE: COLLAGEN ALPHA-1 (III) CHAIN;

COMPND 10 CHAIN: C;

COMPND 11 FRAGMENT: CPROPEPTIDE OF PROCOLLAGEN III, RESIDUES 919-1163;

COMPND 12 SYNONYM: PROCOLLAGEN III;

COMPND 13 ENGINEERED: YES;

COMPND 14 MUTATION: YES

SOURCE MOL ID: 1;

SOURCE 2 ORGANISM SCIENTIFIC: HOMO SAPIENS;

SOURCE 3 ORGANISM COMMON: HUMAN;

SOURCE 4 ORGANISM TAXID : 9606;

SOURCE 5 EXPRESSION SYSTEM: HOMO SAPIENS;

SOURCE 6 EXPRESSION SYSTEM COMMON: HUMAN;

SOURCE 7 EXPRESSION SYSTEM TAXID : 9606;

SOURCE 8 EXPRESSION SYSTEM CELL LINE: HEK 293T;

SOURCE 9 EXPRESSION SYSTEM VECTOR TYPE: PLASMID;

SOURCE 10 EXPRESSION SYSTEM PLASMID: PHLSEC;

SOURCE 11 MOL ID: 2;

SOURCE 12 ORGANISM SCIENTIFIC: HOMO SAPIENS;

SOURCE 13 ORGANISM COMMON: HUMAN;

SOURCE 14 ORGANISM TAXID : 9606;

SOURCE 15 EXPRESSION SYSTEM: HOMO SAPIENS;

SOURCE 16 EXPRESSION SYSTEM COMMON: HUMAN;

SOURCE 17 EXPRESSION SYSTEM TAXID : 9606;

SOURCE 18 EXPRESSION SYSTEM CELL LINE: HEK 293T;

SOURCE 19 EXPRESSION SYSTEM VECTOR TYPE: PLASMID;

SOURCE 20 EXPRESSION SYSTEM PLASMID: PHLSEC

KEYWDS STRUCTURAL PROTEIN, EXTRACELLULAR, MATRIX, FIBROSIS, TRIMER

EXPDTA X-RAY DIFFRACTION

AUTHOR J. M. BOURHIS, N.MARIANO, Y . ZHAO, K . HARLOS , E . Y . JONES , C . MOALI , N . AGHAJARI ,

AUTHOR 2 D. J. S . HULMES

REVDAT 1 ll-JAN-12 4AEJ 0

JRNL AUTH J. M. BOURHIS, N.MARIANO, Y . ZHAO, K . HARLOS , E . Y . JONES , C . MOALI ,

JRNL AUTH 2 N. AGHAJARI, D. J. S . HULMES

JRNL TITL STRUCTURAL BASIS OF FIBRILLAR PROCOLLAGEN TRIMERIZATION AND

JRNL TITL 2 ASSOCIATED TISSUE DISORDERS

JRNL REF TO BE PUBLISHED

JRNL REFN

REMARK 1

REMARK 1 REFERENCE 1

REMARK 1 AUTH J. M. BOURHIS, N.MARIANO, Y . ZHAO, T . S . WALTER, K . HARLOS , C . MOALI ,

REMARK 1 AUTH 2 D. J. S . HULMES, N. AGHAJARI

REMARK 1 TITL LARGE SCALE PRODUCTION AND CRYSTALLISATION OF THE

REMARK 1 TITL 2 C-PROPEPTIDE TRIMER FROM PROCOLLAGEN III FOR HIGH

REMARK 1 TITL 3 RESOLUTION STRUCTURE DETERMINATION

REMARK 1 REF TO BE PUBLISHED

REMARK 1 REFN

REMARK 2

REMARK 2 RESOLUTION. 2.21 ANGSTROMS. REMARK

REMARK REFINEMENT .

REMARK PROGRAM REFMAC 5.6.0117

REMARK AUTHORS MURSHUDOV, VAGIN, DODSON

REMARK REMARK REFINEMENT TARGET MAXIMUM LIKELIHOOD REMARK REMARK DATA USED IN REFINEMENT.

REMARK RESOLUTION RANGE HIGH (ANGSTROMS) 2.21

REMARK RESOLUTION RANGE LOW (ANGSTROMS) 39.41

REMARK DATA CUTOFF (SIGMA(F)) NONE

REMARK COMPLETENESS FOR RANGE (%) 99.97

REMARK NUMBER OF REFLECTIONS 36672

REMARK REMARK FIT TO DATA USED IN REFINEMENT.

REMARK CROSS-VALIDATION METHOD THROUGHOUT

REMARK FREE R VALUE TEST SET SELECTION RANDOM REMARK R VALUE (WORKING + TEST SET) 0.20308

REMARK R VALUE (WORKING SET) 0.20125

REMARK FREE R VALUE 0.23686

REMARK FREE R VALUE TEST SET SIZE (%) 5.0

REMARK FREE R VALUE TEST SET COUNT 1932

REMARK REMARK FIT IN THE HIGHEST RESOLUTION BIN.

REMARK TOTAL NUMBER OF BINS USED 20

REMARK BIN RESOLUTION RANGE HIGH (A) 2.215

REMARK BIN RESOLUTION RANGE LOW (A) 2.272

REMARK REFLECTION IN BIN (WORKING SET) 2493

REMARK BIN COMPLETENESS (WORKING+TEST) (%) 100.00

REMARK BIN R VALUE (WORKING SET) 0.245

REMARK BIN FREE R VALUE SET COUNT 112

REMARK BIN FREE R VALUE 0.304

REMARK REMARK NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.

REMARK PROTEIN ATOMS : 4950

REMARK NUCLEIC ACID ATOMS : 0

REMARK HETEROGEN ATOMS : 149

REMARK SOLVENT ATOMS : 179

REMARK REMARK B VALUES.

REMARK FROM WILSON PLOT (A**2) NULL

REMARK MEAN B VALUE (OVERALL, A**2) 33.634

REMARK OVERALL ANISOTROPIC B VALUE REMARK Bll (A**2) 0. 02

REMARK B22 (A**2) -0 .01

REMARK B33 (A**2) -0 .01

REMARK B12 (A**2) 0. 00

REMARK B13 (A**2) 0. 00

REMARK B23 (A**2) 0. 00

REMARK REMARK ESTIMATED OVERALL COORDINATE ERROR.

REMARK ESU BASED ON R VALUE (A) 0.263 REMARK ESU BASED ON FREE R VALUE (A) 0.202 REMARK ESU BASED ON MAXIMUM LIKELIHOOD (A) 143 REMARK ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD *2) 650 REMARK REMARK CORRELATION COEFFICIENTS.

REMARK CORRELATION COEFFICIENT FO-FC 0.941

REMARK CORRELATION COEFFICIENT FO-FC FREE 0.924

REMARK REMARK RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A) 5214 ; 0.009 ; 0.020

REMARK 3 BOND LENGTHS OTHERS (A) NULL ; NULL ; NULL

REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES) 7055 ; 1.312 ; 1.959

REMARK 3 BOND ANGLES OTHERS (DEGREES) NULL ; NULL ; NULL

REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES) 639 ; 6.391 ; 5.000

REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES) 242 ; 36.991 ; 24.298

REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES) 804 ; 15.188 ; 15.000

REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES) 27 ; 17.887 ; 15.000

REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3) 735 ; 0.086 ; 0.200

REMARK 3 GENERAL PLANES REFINED ATOMS (A) 4011 ; 0.005 ; 0.021

REMARK 3 GENERAL PLANES OTHERS (A) NULL ; NULL ; NULL

REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 NON-BONDED CONTACTS OTHERS (A) NULL ; NULL ; NULL

REMARK 3 NON-BONDED TORSION REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 NON-BONDED TORSION OTHERS (A) NULL ; NULL ; NULL

REMARK 3 H-BOND (X...Y) REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 H-BOND (X...Y) OTHERS (A) NULL ; NULL ; NULL

REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 POTENTIAL METAL-ION OTHERS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY VDW REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY VDW OTHERS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY H-BOND OTHERS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A) NULL ; NULL ; NULL

REMARK 3 SYMMETRY METAL-ION OTHERS (A) NULL ; NULL ; NULL

REMARK 3

REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT

REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3

REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT

REMARK 3 RIGID-BOND RESTRAINTS (A**2) NULL ; NULL ; NULL

REMARK 3 SPHERICITY; FREE ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3 SPHERICITY; BONDED ATOMS (A**2) NULL ; NULL ; NULL

REMARK 3

REMARK 3 NCS RESTRAINTS STATISTICS

REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : NULL

REMARK 3

REMARK 3 TLS DETAILS

REMARK 3 NUMBER OF TLS GROUPS : NULL

REMARK 3

REMARK 3 BULK SOLVENT MODELLING.

REMARK 3 METHOD USED : MASK

REMARK 3 PARAMETERS FOR MASK CALCULATION

REMARK 3 VDW PROBE RADIUS : 1.20

REMARK 3 ION PROBE RADIUS : 0.80

REMARK 3 SHRINKAGE RADIUS : 0.80

REMARK 3

REMARK 3 OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE

REMARK 3 RIDING POSITIONS.

REMARK 4

REMARK 4 4AEJ COMPLIES WITH FORMAT V. 3.30, 13-JUL-ll

REMARK 100

REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 11-JAN- 12.

REMARK 100 THE PDBE ID CODE IS EBI-50878.

REMARK 200

REMARK 200 EXPERIMENTAL DETAILS

REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION 22-JUL-ll

REMARK 200 TEMPERATURE (KELVIN) 100

REMARK 200 PH NULL

REMARK 200 NUMBER OF CRYSTALS USED 1

REMARK 200

REMARK 200 SYNCHROTRON (Y/N) Y

REMARK 200 RADIATION SOURCE DIAMOND

REMARK 200 BEAMLINE 103

REMARK 200 X-RAY GENERATOR MODEL NULL

REMARK 200 MONOCHROMATIC OR LAUE (M/L) M

REMARK 200 WAVELENGTH OR RANGE (A) 0.9796

REMARK 200 MONOCHROMATOR NULL

REMARK 200 OPTICS NULL

REMARK 200

REMARK 200 DETECTOR TYPE CCD

REMARK 200 DETECTOR MANUFACTURER ADSC

REMARK 200 INTENSITY-INTEGRATION SOFTWARE MOSFLM

REMARK 200 DATA SCALING SOFTWARE SCALA

REMARK 200

REMARK 200 NUMBER OF UNIQUE REFLECTIONS 38676

REMARK 200 RESOLUTION RANGE HIGH (A) 2.20

REMARK 200 RESOLUTION RANGE LOW (A) 101.50

REMARK 200 REJECTION CRITERIA (SIGMA(I)) 4.0

REMARK 200

REMARK 200 OVERALL .

REMARK 200 COMPLETENESS FOR RANGE (%) 100.0

REMARK 200 DATA REDUNDANCY 14.4

REMARK 200 R MERGE (I) 0.11

REMARK 200 R SYM (I) NULL

REMARK 200 <I/SIGMA(I)> FOR THE DATA SET 19.00

REMARK 200

REMARK 200 IN THE HIGHEST RESOLUTION SHELL

REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) 2.21

REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) 2.27

REMARK 200 COMPLETENESS FOR SHELL (%) 100.0

REMARK 200 DATA REDUNDANCY IN SHELL 14.7

REMARK 200 R MERGE FOR SHELL (I) 0.81

REMARK 200 R SYM FOR SHELL (I) NULL

REMARK 200 <I/SIGMA(I)> FOR SHELL 4.00

REMARK 200

REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH

REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD

REMARK 200 SOFTWARE USED: PHENIX

REMARK 200 STARTING MODEL: NONE

REMARK 200

REMARK 200 REMARK : NONE

REMARK 280

REMARK 280 CRYSTAL

REMARK 280 SOLVENT CONTENT, VS (%) : 46.5

REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS ** 3 /DA) : 2.3

REMARK 280

REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG 3350, 0.2 M NACL

REMARK 290

REMARK 290 CRYSTALLOGRAPHIC SYMMETRY

REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21

REMARK 290

REMARK 290 SYMOP SYMMETRY

REMARK 290 NNNMMM OPERATOR

REMARK 290 1555 Χ,Υ,Ζ

REMARK 290 2555 -X+l/2, -Y, Z+l/2

REMARK 290 3555 -X, Y+l/2, -Z+l/2 REMARK 290 4555 X+l/2, -Y+l/2, -Z

REMARK 290

REMARK 290 WHERE NNN -> OPERATOR NUMBER

REMARK 290 MMM -> TRANSLATION VECTOR

REMARK 290

REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS

REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM

REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY

REMARK 290 RELATED MOLECULES.

REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0. 00000

REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0. 00000

REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0. 00000

REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 41. 96500

REMARK 290 SMTRY2 2 0.000000 -1.000000 0.000000 0. 00000

REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 50. 73000

REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0. 00000

REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 44. 63500

REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 50. 73000

REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 41. 96500

REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 44. 63500

REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0. 00000

REMARK 290

REMARK 290 REMARK: NULL

REMARK 300

REMARK 300 BIOMOLECULE: 1

REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM

REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN

REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON

REMARK 300 BURIED SURFACE AREA.

REMARK 350

REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE ; KNOWN

REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE

REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS

REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND

REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.

REMARK 350

REMARK 350 BIOMOLECULE: 1

REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC

REMARK 350 SOFTWARE USED: PISA

REMARK 350 TOTAL BURIED SURFACE AREA: 5630 ANGSTROM* * 2

REMARK 350 SURFACE AREA OF THE COMPLEX: 27990 ANGSTROM* * 2

REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -68.7 KCAL/MOL

REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C

REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0. 00000

REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0. 00000

REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0. 00000

REMARK 400

REMARK 400 COMPOUND

REMARK 400 ENGINEERED RESIDUE IN CHAIN A, ASN1064 TO GLN

REMARK 400 ENGINEERED RESIDUE IN CHAIN B, ASN1064 TO GLN

REMARK 400 ENGINEERED RESIDUE IN CHAIN C, ASN1064 TO GLN

REMARK 465

REMARK 465 MISSING RESIDUES

REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE

REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN

REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE. )

REMARK 465

REMARK 465 M RES C SSSEQI

REMARK 465 GLU A -10

REMARK 465 THR A -9

REMARK 465 GLY A -8 REMARK 465 HIS A -7

REMARK 465 HIS A -6

REMARK 465 HIS A -5

REMARK 465 HIS A -4

REMARK 465 HIS A -3

REMARK 465 HIS A -2

REMARK 465 SER A -1

REMARK 465 ALA A 0

REMARK 465 ASP A 1

REMARK 465 GLU A 2

REMARK 465 PRO A 3

REMARK 465 MSE A 4

REMARK 465 ASP A 5

REMARK 465 PHE A 6

REMARK 465 LYS A 7

REMARK 465 ILE A 8

REMARK 465 ASN A 9

REMARK 465 THR A 10

REMARK 465 ASP A 11

REMARK 465 GLU A 12

REMARK 465 ILE A 13

REMARK 465 MSE A 14

REMARK 465 THR A 15

REMARK 465 SER A 16

REMARK 465 LEU A 17

REMARK 465 LYS A 18

REMARK 465 SER A 19

REMARK 465 VAL A 20

REMARK 465 ASN A 21

REMARK 465 GLY A 22

REMARK 465 GLN A 23

REMARK 465 ILE A 24

REMARK 465 GLU A 25

REMARK 465 SER A 26

REMARK 465 LEU A 27

REMARK 465 ILE A 28

REMARK 465 SER A 98

REMARK 465 SER A 99

REMARK 465 ALA A 100

REMARK 465 GLU A 101

REMARK 465 GLU B -10

REMARK 465 THR B -9

REMARK 465 GLY B -8

REMARK 465 HIS B -7

REMARK 465 HIS B -6

REMARK 465 HIS B -5

REMARK 465 HIS B -4

REMARK 465 HIS B -3

REMARK 465 HIS B -2

REMARK 465 SER B -1

REMARK 465 ALA B 0

REMARK 465 ASP B 1

REMARK 465 GLU B 2

REMARK 465 PRO B 3

REMARK 465 MSE B 4

REMARK 465 ASP B 5

REMARK 465 PHE B 6

REMARK 465 LYS B 7

REMARK 465 ILE B 8

REMARK 465 ASN B 9

REMARK 465 THR B 10 REMARK 465 ASP B 11

REMARK 465 GLU B 12

REMARK 465 ILE B 13

REMARK 465 MSE B 14

REMARK 465 THR B 15

REMARK 465 SER B 16

REMARK 465 LEU B 17

REMARK 465 LYS B 18

REMARK 465 SER B 19

REMARK 465 VAL B 20

REMARK 465 ASN B 21

REMARK 465 GLY B 22

REMARK 465 GLN B 23

REMARK 465 ILE B 24

REMARK 465 GLU B 25

REMARK 465 SER B 26

REMARK 465 LEU B 27

REMARK 465 GLU C -10

REMARK 465 THR C -9

REMARK 465 GLY C -8

REMARK 465 HIS C -7

REMARK 465 HIS C -6

REMARK 465 HIS C -5

REMARK 465 HIS C -4

REMARK 465 HIS C -3

REMARK 465 HIS C -2

REMARK 465 SER C -1

REMARK 465 ALA C 0

REMARK 465 ASP C 1

REMARK 465 GLU C 2

REMARK 465 PRO C 3

REMARK 465 MSE C 4

REMARK 465 ASP C 5

REMARK 465 PHE C 6

REMARK 465 LYS C 7

REMARK 465 ILE C 8

REMARK 465 ASN C 9

REMARK 465 THR C 10

REMARK 465 ASP C 11

REMARK 465 GLU C 12

REMARK 465 ILE C 13

REMARK 465 MSE C 14

REMARK 465 THR C 15

REMARK 465 SER c 16

REMARK 465 LEU c 17

REMARK 465 LYS c 18

REMARK 465 SER c 19

REMARK 465 VAL c 20

REMARK 465 ASN c 21

REMARK 465 GLY c 22

REMARK 465 GLN c 23

REMARK 465 ILE c 24

REMARK 465 GLU c 25

REMARK 465 SER c 26

REMARK 465 LEU c 27

REMARK 465 SER c 98

REMARK 465 SER c 99

REMARK 465 ALA c 100

REMARK 465 GLU c 101

REMARK 465 LYS c 102

REMARK 465 GLU c 176 REMARK 470

REMARK 470 MISSING ATOM

REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE

REMARK 470 M RES CS SEQI ATOMS

REMARK 470 LYS A 35 CE NZ

REMARK 470 LYS A 103 CG CD CE NZ

REMARK 470 LYS A 166 CD CE NZ

REMARK 470 GLU A 176 CG CD OE1 OE2

REMARK 470 LYS A 186 CD CE NZ

REMARK 470 LYS A 198 CE NZ

REMARK 470 ILE B 28 CGI CG2 CD1

REMARK 470 GLU B 76 CD OE1 OE2

REMARK 470 ILE C 28 CGI CG2 CD1

REMARK 470 GLU C 76 CG CD OE1 OE2

REMARK 470 LYS C 103 CG CD CE NZ

REMARK 470 ASP C 112 CG OD1 OD2

REMARK 470 GLU C 126 CD OE1 OE2

REMARK 470 GLN C 160 CG CD OE1 NE2

REMARK 470 LYS C 166 CG CD CE NZ

REMARK 470 ASN C 175 CG OD1 ND2

REMARK 470 LYS C 186 CE NZ

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC

REMARK 500

REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.

REMARK 500

REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 OD2 ASP B 127 NH1 ARG C 42 2.04 REMARK 500

REMARK 500 REMARK: NULL

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: CLOSE CONTACTS

REMARK 500

REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15 REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375 REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS. REMARK 500

REMARK 500 DISTANCE CUTOFF:

REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS

REMARK 500

REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE REMARK 500 ND1 HIS B 48 OE2 GLU C 193 2455 1.74 REMARK 500 OE2 GLU B 50 OE2 GLU C 193 2455 2.09 REMARK 500

REMARK 500 REMARK: NULL

REMARK 500

REMARK 500 GEOMETRY AND STEREOCHEMISTRY

REMARK 500 SUBTOPIC: TORSION ANGLES

REMARK 500

REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;

REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE) .

REMARK 500 REMARK 500 STANDARD TABLE:

REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)

REMARK 500

REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996) . PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500

REMARK 500 M RES CSSEQI PSI PHI

REMARK 500 GLN A 62 -136 .64 49 .35

REMARK 500 SER A 110 -8 .60 -141 .34

REMARK 500 ASN A 121 113 .75 -37 .97

REMARK 500 TYR A 157 -79 .00 -135 .00

REMARK 500 GLU A 176 8 .50 52 .72

REMARK 500 LYS A 214 79 .51 -113 .89

REMARK 500 GLN B 62 -139 .12 52 .11

REMARK 500 TYR B 157 -74 .50 -142 .37

REMARK 500 LYS B 214 79 .06 -108 .78

REMARK 500 GLN C 62 -140 .22 56 .45

REMARK 500 TYR C 157 -77 .71 -135 .90

REMARK 500 TYR C 226 -61 .83 -95 .03

REMARK 500 ASP C 227 77 .72 -69 .13

REMARK 500

REMARK 500 REMARK: NULL

REMARK 525

REMARK 525 SOLVENT

REMARK 525

REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT

REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST

REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT

REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE

REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;

REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE

REMARK 525 NUMBER; I=INSERTION CODE) :

REMARK 525

REMARK 525 M RES CSSEQI

REMARK 525 HOH H 52 DISTANCE 5.2 ANGSTROMS

REMARK 525

REMARK 525 THE FOLLOWING SOLVENT MOLECULES LIE FARTHER THAN EXPECTED REMARK 525 FROM THE PROTEIN OR NUCLEIC ACID MOLECULE AND ARE

REMARK 525 ASSOCIATED WITH A SYMMETRY RELATED MOLECULE (M=MODEL

REMARK 525 NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE REMARK 525 NUMBER; I=INSERTION CODE) : THESE HAVE BEEN REPOSITIONED

REMARK 525 BY APPLYING THE SYMMETRY TRANSFORMATION INDICATED.

REMARK 525

REMARK 525 RES CSSEQI ORIGINAL COORDINATES SYMMETRY TRANS . DIST REMARK 525 X Y Z

REMARK 525 HOH H 32 -16.028 -25. , 905 14.789 003 555 2.64 REMARK 525 HOH H 152 -2.138 -35. , 338 14.649 003 555 3.28 REMARK 525 HOH H 134 -33.397 -17. , 394 22.983 004 545 2.58 REMARK 525 HOH H 106 -0.704 8. .222 36.967 003 545 2.72 REMARK 525 HOH H 68 -2.443 6. .467 41.329 003 545 3.05 REMARK 620

REMARK 620 METAL COORDINATION

REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;

REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE) :

REMARK 620

REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL

REMARK 620 CA A 246 CA

REMARK 620 N RES CSSEQI ATOM

REMARK 620 1 HOH A2025 O

REMARK 620 2 ASP A 59 OD1 146.4

REMARK 620 3 ASP A 59 OD2 161.4 52.1 REMARK 620 4 ASN A 61 OD1 83.9 78.6 107.3

REMARK 620 5 GLN A 62 O 86.5 1 18. 7 80.5 82.4

REMARK 620 6 CYS A 64 O 82.3 1 15. 2 85.2 165.7 93. 2

REMARK 620 7 ASP A 67 OD1 74.2 81. 2 116.7 100.7 159. 9 78.9

REMARK 620 N 1 2 3 4 5 6

REMARK 620

REMARK 620 COORDINATION . ANGLES FOR: M RES CSSEQI METAL

REMARK 620 CA B 246 CA

REMARK 620 N RES CSSEQI . ATOM

REMARK 620 1 CYS B 64 O

REMARK 620 2 ASP B 67 OD1 83.2

REMARK 620 3 ASP B 59 OD1 113.7 81. 9

REMARK 620 4 ASP B 59 OD2 75.9 1 15. 3 54.6

REMARK 620 5 ASN B 61 OD1 172.1 96. 2 73.8 111.2

REMARK 620 6 GLN B 62 O 87.4 1 62. 1 115.9 76.7 91. 0

REMARK 620 7 HOH B2021 O 91.1 78. 3 146.0 159.2 81. 1 86.7

REMARK 620 N 1 2 3 4 5 6

REMARK 620

REMARK 620 COORDINATION . ANGLES FOR: M RES CSSEQI METAL

REMARK 620 CA C 246 CA

REMARK 620 N RES CSSEQI . ATOM

REMARK 620 1 ASP C 59 OD1

REMARK 620 2 ASP C 59 OD2 52.9

REMARK 620 3 GLN C 62 O 123.4 83. 5

REMARK 620 4 CYS C 64 O 112.9 80. 3 88.9

REMARK 620 5 ASP C 67 OD1 77.6 1 12. 3 159.0 80.6

REMARK 620 6 ASN C 61 OD1 80.6 1 12. 1 86.2 166.0 99. 6

REMARK 620 7 HOH A2012 O 146.2 1 60. 7 83.1 85.7 78. 0 80.8

REMARK 620 N 1 2 3 4 5 6

REMARK 800

REMARK 800 SITE

REMARK 800 SITE IDENTIFIER: AC1

REMARK 800 EVIDENCE CODE : SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SI TE FOR RESIDUE CA A 246

REMARK 800

REMARK 800 SITE IDENTIFIER: AC2

REMARK 800 EVIDENCE CODE : SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SI TE FOR RESIDUE GOL A1246

REMARK 800

REMARK 800 SITE IDENTIFIER: AC3

REMARK 800 EVIDENCE CODE : SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SI TE FOR RESIDUE GOL A1247

REMARK 800

REMARK 800 SITE IDENTIFIER: AC4

REMARK 800 EVIDENCE CODE : SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SI TE FOR RESIDUE GOL A1248

REMARK 800

REMARK 800 SITE IDENTIFIER: AC5

REMARK 800 EVIDENCE CODE : SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SI TE FOR RESIDUE GOL A1249

REMARK 800

REMARK 800 SITE IDENTIFIER: AC6

REMARK 800 EVIDENCE CODE : SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SI TE FOR RESIDUE GOL A1250

REMARK 800

REMARK 800 SITE IDENTIFIER: AC7

REMARK 800 EVIDENCE CODE : SOFTWARE

REMARK 800 SITE DESCRIPTION: BINDING SI TE FOR RESIDUE CA B 246

REMARK 800

REMARK 800 SITE IDENTIFIER: AC8

REMARK 800 EVIDENCE CODE : SOFTWARE REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B1246

REMARK 800

REMARK 800 S ITE_IDENTIFIER : AC9

REMARK 800 EVIDENCE_CODE : SOFTWARE

REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B1247

REMARK 800

REMARK 800 S ITE_IDENTIFIER : BC1

REMARK 800 EVIDENCE_CODE : SOFTWARE

REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 246

REMARK 900

REMARK 900 RELATED ENTRIES

REMARK 900 RELATED ID: 4AE2 RELATED DB : PDB

REMARK 900 CRYSTAL STRUCTURE OF HUMAN FIBRILLAR PROCOLLAGEN TYPE

REMARK 900 III C-PROPEPTIDE TRIMER

REMARK 900 RELATED ID: 2V53 RELATED DB : PDB

REMARK 900 CRYSTAL STRUCTURE OF A SPARC-COLLAGEN COMPLEX

DBREF 4AEJ A 1 245 UNE P02461 C03A1_ HUMAN 91 S ⁾ 1163

DBREF 4AEJ B 1 245 UNE P02461 C03A1_ HUMAN 91 S ⁾ 1163

DBREF 4AEJ C 1 245 UNE P02461 C03A1_ HUMAN 91 S ⁾ 1163

SEQADV 4AEJ GLU A -10 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ THR A -9 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ GLY A -8 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS A -7 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS A -6 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS A -5 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS A -4 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS A -3 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS A -2 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ SER A -1 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ ALA A 0 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ GLN A 132 UNP P02461 HIS 1050 CONFLICT

SEQADV 4AEJ GLN A 146 UNP P02461 ASN 1064 ENGINEERED MUTATION

SEQADV 4AEJ GLU B -10 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ THR B -9 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ GLY B -8 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS B -7 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS B -6 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS B -5 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS B -4 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS B -3 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS B -2 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ SER B -1 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ ALA B 0 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ GLN B 132 UNP P02461 HIS 1050 CONFLICT

SEQADV 4AEJ GLN B 146 UNP P02461 ASN 1064 ENGINEERED MUTATION

SEQADV 4AEJ GLU C -10 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ THR C -9 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ GLY C -8 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS C -7 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS C -6 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS C -5 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS C -4 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS C -3 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ HIS C -2 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ SER C -1 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ ALA C 0 UNP P02461 EXPRESSION TAG

SEQADV 4AEJ PHE C 93 UNP P02461 HIS 1011 CONFLICT

SEQADV 4AEJ GLN C 132 UNP P02461 HIS 1050 CONFLICT

SEQADV 4AEJ GLN C 146 UNP P02461 ASN 1064 ENGINEERED MUTATION

SEQRES 1 A 256 GLU THR GLY HIS HIS HIS HIS HIS HIS SER ALA ASP GLU

SEQRES 2 A 256 PRO MSE ASP PHE LYS ILE ASN THR ASP GLU ILE MSE THR SEQRES 3 A 256 SER LEU LYS SER VAL ASN GLY GLN ILE GLU SER LEU ILE

SEQRES 4 A 256 SER PRO ASP GLY SER ARG LYS ASN PRO ALA ARG ASN CYS

SEQRES 5 A 256 ARG ASP LEU LYS PHE CYS HIS PRO GLU LEU LYS SER GLY

SEQRES 6 A 256 GLU TYR TRP VAL ASP PRO ASN GLN GLY CYS LYS LEU ASP

SEQRES 7 A 256 ALA ILE LYS VAL PHE CYS ASN MSE GLU THR GLY GLU THR

SEQRES 8 A 256 CYS ILE SER ALA ASN PRO LEU ASN VAL PRO ARG LYS HIS

SEQRES 9 A 256 TRP TRP THR ASP SER SER ALA GLU LYS LYS HIS VAL TRP

SEQRES 10 A 256 PHE GLY GLU SER MSE ASP GLY GLY PHE GLN PHE SER TYR

SEQRES 11 A 256 GLY ASN PRO GLU LEU PRO GLU ASP VAL LEU ASP VAL GLN

SEQRES 12 A 256 LEU ALA PHE LEU ARG LEU LEU SER SER ARG ALA SER GLN

SEQRES 13 A 256 GLN ILE THR TYR HIS CYS LYS ASN SER ILE ALA TYR MSE

SEQRES 14 A 256 ASP GLN ALA SER GLY ASN VAL LYS LYS ALA LEU LYS LEU

SEQRES 15 A 256 MSE GLY SER ASN GLU GLY GLU PHE LYS ALA GLU GLY ASN

SEQRES 16 A 256 SER LYS PHE THR TYR THR VAL LEU GLU ASP GLY CYS THR

SEQRES 17 A 256 LYS HIS THR GLY GLU TRP SER LYS THR VAL PHE GLU TYR

SEQRES 18 A 256 ARG THR ARG LYS ALA VAL ARG LEU PRO ILE VAL ASP ILE

SEQRES 19 A 256 ALA PRO TYR ASP ILE GLY GLY PRO ASP GLN GLU PHE GLY

SEQRES 20 A 256 VAL ASP VAL GLY PRO VAL CYS PHE LEU

SEQRES 1 B 256 GLU THR GLY HIS HIS HIS HIS HIS HIS SER ALA ASP GLU

SEQRES 2 B 256 PRO MSE ASP PHE LYS ILE ASN THR ASP GLU ILE MSE THR

SEQRES 3 B 256 SER LEU LYS SER VAL ASN GLY GLN ILE GLU SER LEU ILE

SEQRES 4 B 256 SER PRO ASP GLY SER ARG LYS ASN PRO ALA ARG ASN CYS

SEQRES 5 B 256 ARG ASP LEU LYS PHE CYS HIS PRO GLU LEU LYS SER GLY

SEQRES 6 B 256 GLU TYR TRP VAL ASP PRO ASN GLN GLY CYS LYS LEU ASP

SEQRES 7 B 256 ALA ILE LYS VAL PHE CYS ASN MSE GLU THR GLY GLU THR

SEQRES 8 B 256 CYS ILE SER ALA ASN PRO LEU ASN VAL PRO ARG LYS HIS

SEQRES 9 B 256 TRP TRP THR ASP SER SER ALA GLU LYS LYS HIS VAL TRP

SEQRES 10 B 256 PHE GLY GLU SER MSE ASP GLY GLY PHE GLN PHE SER TYR

SEQRES 11 B 256 GLY ASN PRO GLU LEU PRO GLU ASP VAL LEU ASP VAL GLN

SEQRES 12 B 256 LEU ALA PHE LEU ARG LEU LEU SER SER ARG ALA SER GLN

SEQRES 13 B 256 GLN ILE THR TYR HIS CYS LYS ASN SER ILE ALA TYR MSE

SEQRES 14 B 256 ASP GLN ALA SER GLY ASN VAL LYS LYS ALA LEU LYS LEU

SEQRES 15 B 256 MSE GLY SER ASN GLU GLY GLU PHE LYS ALA GLU GLY ASN

SEQRES 16 B 256 SER LYS PHE THR TYR THR VAL LEU GLU ASP GLY CYS THR

SEQRES 17 B 256 LYS HIS THR GLY GLU TRP SER LYS THR VAL PHE GLU TYR

SEQRES 18 B 256 ARG THR ARG LYS ALA VAL ARG LEU PRO ILE VAL ASP ILE

SEQRES 19 B 256 ALA PRO TYR ASP ILE GLY GLY PRO ASP GLN GLU PHE GLY

SEQRES 20 B 256 VAL ASP VAL GLY PRO VAL CYS PHE LEU

SEQRES 1 C 256 GLU THR GLY HIS HIS HIS HIS HIS HIS SER ALA ASP GLU

SEQRES 2 C 256 PRO MSE ASP PHE LYS ILE ASN THR ASP GLU ILE MSE THR

SEQRES 3 C 256 SER LEU LYS SER VAL ASN GLY GLN ILE GLU SER LEU ILE

SEQRES 4 C 256 SER PRO ASP GLY SER ARG LYS ASN PRO ALA ARG ASN CYS

SEQRES 5 C 256 ARG ASP LEU LYS PHE CYS HIS PRO GLU LEU LYS SER GLY

SEQRES 6 C 256 GLU TYR TRP VAL ASP PRO ASN GLN GLY CYS LYS LEU ASP

SEQRES 7 C 256 ALA ILE LYS VAL PHE CYS ASN MSE GLU THR GLY GLU THR

SEQRES 8 C 256 CYS ILE SER ALA ASN PRO LEU ASN VAL PRO ARG LYS PHE

SEQRES 9 C 256 TRP TRP THR ASP SER SER ALA GLU LYS LYS HIS VAL TRP

SEQRES 10 C 256 PHE GLY GLU SER MSE ASP GLY GLY PHE GLN PHE SER TYR

SEQRES 11 C 256 GLY ASN PRO GLU LEU PRO GLU ASP VAL LEU ASP VAL GLN

SEQRES 12 C 256 LEU ALA PHE LEU ARG LEU LEU SER SER ARG ALA SER GLN

SEQRES 13 C 256 GLN ILE THR TYR HIS CYS LYS ASN SER ILE ALA TYR MSE

SEQRES 14 C 256 ASP GLN ALA SER GLY ASN VAL LYS LYS ALA LEU LYS LEU

SEQRES 15 C 256 MSE GLY SER ASN GLU GLY GLU PHE LYS ALA GLU GLY ASN

SEQRES 16 C 256 SER LYS PHE THR TYR THR VAL LEU GLU ASP GLY CYS THR

SEQRES 17 C 256 LYS HIS THR GLY GLU TRP SER LYS THR VAL PHE GLU TYR

SEQRES 18 C 256 ARG THR ARG LYS ALA VAL ARG LEU PRO ILE VAL ASP ILE

SEQRES 19 C 256 ALA PRO TYR ASP ILE GLY GLY PRO ASP GLN GLU PHE GLY

SEQRES 20 C 256 VAL ASP VAL GLY PRO VAL CYS PHE LEU

MODRES 4AEJ MSE A 75 MET SELENOMETHIONINE

MODRES 4AEJ MSE A 111 MET SELENOMETHIONINE

MODRES 4AEJ MSE A 158 MET SELENOMETHIONINE MODRES 4AEJ MSE A 172 MET SELENOMETHIONINE

MODRES 4AEJ MSE B 75 MET SELENOMETHIONINE

MODRES 4AEJ MSE B 111 MET SELENOMETHIONINE

MODRES 4AEJ MSE B 158 MET SELENOMETHIONINE

MODRES 4AEJ MSE B 172 MET SELENOMETHIONINE

MODRES 4AEJ MSE C 75 MET SELENOMETHIONINE

MODRES 4AEJ MSE C 111 MET SELENOMETHIONINE

MODRES 4AEJ MSE C 158 MET SELENOMETHIONINE

MODRES 4AEJ MSE C 172 MET SELENOMETHIONINE

HET MSE A 75 8

HET MSE A 111 8

HET MSE A 158 8

HET MSE A 172 8

HET MSE B 75 8

HET MSE B 111 8

HET MSE B 158 8

HET MSE B 172 16

HET MSE C 75 8

HET MSE C 111 8

HET MSE C 158 8

HET MSE C 172 8

HET CA A 246 1

HET GOL A1246 6

HET GOL A1247 6

HET GOL A1248 6

HET GOL A1249 6

HET GOL A1250 6

HET CA B 246 1

HET GOL B1246 6

HET GOL B1247 6

HET CA C 246 1

HETNAM MSE SELENOMETHIONINE

HETNAM CA CALCIUM ION

HETNAM GOL GLYCEROL

HETSYN GOL GLYCERIN; PROPANE- 1,2, 3-TRIOL

FORMUL 4 MSE 12 (C5 HI 1 N 02 SE)

FORMUL 5 CA 3 (CA 2+ )

FORMUL 6 GOL 7 (C3 H8 03)

FORMUL 7 HOH *179(H2 ' 0)

HELIX 1 1 ASN A 40 HIS A 48 1 9

HELIX 2 2 CYS A 64 ALA A 68 5 5

HELIX 3 3 TRP A 106 MSE A 111 1 6

HELIX 4 4 PRO A 125 SER A 140 1 16

HELIX 5 5 LYS A 214 LEU A 218 5 5

HELIX 6 6 ASN B 40 HIS B 48 1 9

HELIX 7 7 CYS B 64 ALA B 68 5 5

HELIX 8 8 TRP B 106 MSE B 111 1 6

HELIX 9 9 PRO B 125 SER B 140 1 16

HELIX 10 10 LYS B 214 LEU B 218 5 5

HELIX 11 11 ASN C 40 HIS C 48 1 9

HELIX 12 12 CYS C 64 ALA C 68 5 5

HELIX 13 13 TRP C 106 MSE C 111 1 6

HELIX 14 14 PRO C 125 LEU C 139 1 15

HELIX 15 15 ASN C 184 PHE C 187 5 4

HELIX 16 16 LYS C 214 LEU C 218 5 5

SHEET 1 AA 7 GLY A 54 VAL , A 58 0

SHEET 2 AA 7 ILE A 69 ASN [ A 74 -1 O ILE A 69 N VAL A 58

SHEET 3 AA 7 GLU A 79 ILE ; A 82 -1 O GLU A 79 N ASN A 74

SHEET 4 AA 7 GLU A 234 PHE ; A 244 -1 O VAL A 242 N ILE A 82

SHEET 5 AA 7 ALA A 143 LYS ; A 152 -1 O SER A 144 N CYS A 243

SHEET 6 AA 7 TRP A 203 THR A 212 -1 O SER A 204 N CYS A 151 SHEET 7 AA 7 THR A 190 ASP A 194 -1 0 THR A 190 N GLU A 209

SHEET 1 AB 5 GLY A 54 VAL A 58 0

SHEET 2 AB 5 ILE A 69 ASN A 74 -1 0 ILE A 69 N VAL A 58

SHEET 3 AB 5 GLU A 79 ILE A 82 -1 0 GLU A 79 N ASN A 74

SHEET 4 AB 5 GLU A 234 PHE A 244 -1 0 VAL A 242 N ILE A 82

SHEET 5 AB 5 ASN A 88 LYS A 92 -1 0 VAL A 89 N VAL A 237

SHEET 1 AC 2 ALA A 84 ASN A 85 0

SHEET 2 AC 2 SER A 118 TYR A 119 -1 0 SER A 118 N ASN A 85

SHEET 1 AD 3 GLU A 178 PHE A 179 0

SHEET 2 AD 3 LYS A 170 MSE A 172 -1 0 LEU A 171 N PHE A 179

SHEET 3 AD 3 ASP A 222 ALA A 224 -1 0 ASP A 222 N MSE A 172

SHEET 1 BA 7 GLY B 54 VAL B 58 0

SHEET 2 BA 7 ILE B 69 ASN B 74 -1 0 ILE B 69 N VAL B 58

SHEET 3 BA 7 GLU B 79 ILE B 82 -1 0 GLU B 79 N ASN B 74

SHEET 4 BA 7 VAL B 242 PHE B 244 -1 0 VAL B 242 N ILE B 82

SHEET 5 BA 7 ALA B 143 LYS B 152 -1 0 SER B 144 N CYS B 243

SHEET 6 BA 7 GLU B 234 VAL B 239 -1 0 GLU B 234 N LYS B 152

SHEET 7 BA 7 ASN B 88 LYS B 92 1 0 VAL B 89 N VAL B 237

SHEET 1 BB 7 GLY B 54 VAL B 58 0

SHEET 2 BB 7 ILE B 69 ASN B 74 -1 0 ILE B 69 N VAL B 58

SHEET 3 BB 7 GLU B 79 ILE B 82 -1 0 GLU B 79 N ASN B 74

SHEET 4 BB 7 VAL B 242 PHE B 244 -1 0 VAL B 242 N ILE B 82

SHEET 5 BB 7 ALA B 143 LYS B 152 -1 0 SER B 144 N CYS B 243

SHEET 6 BB 7 TRP B 203 THR B 212 -1 0 SER B 204 N CYS B 151

SHEET 7 BB 7 THR B 190 ASP B 194 -1 0 THR B 190 N GLU B 209

SHEET 1 BC 3 GLU B 178 PHE B 179 0

SHEET 2 BC 3 LYS B 170 MSE B 172 -1 0 LEU B 171 N PHE B 179

SHEET 3 BC 3 ASP B 222 ALA B 224 -1 0 ASP B 222 N MSE B 172

SHEET 1 CA 7 GLY C 54 VAL C 58 0

SHEET 2 CA 7 ILE C 69 ASN C 74 -1 0 ILE C 69 N VAL C 58

SHEET 3 CA 7 GLU C 79 ILE C 82 -1 0 GLU C 79 N ASN C 74

SHEET 4 CA 7 GLU C 234 PHE C 244 -1 0 VAL C 242 N ILE C 82

SHEET 5 CA 7 ALA C 143 LYS C 152 -1 0 SER C 144 N CYS C 243

SHEET 6 CA 7 TRP C 203 THR C 212 -1 0 SER C 204 N CYS C 151

SHEET 7 CA 7 THR C 190 ASP C 194 -1 0 THR C 190 N GLU C 209

SHEET 1 CB 5 GLY C 54 VAL C 58 0

SHEET 2 CB 5 ILE C 69 ASN C 74 -1 0 ILE C 69 N VAL C 58

SHEET 3 CB 5 GLU C 79 ILE C 82 -1 0 GLU C 79 N ASN C 74

SHEET 4 CB 5 GLU C 234 PHE C 244 -1 0 VAL C 242 N ILE C 82

SHEET 5 CB 5 ASN C 88 LYS C 92 1 0 VAL C 89 N VAL C 237

SHEET 1 CC 3 GLU C 178 PHE C 179 0

SHEET 2 CC 3 LYS C 170 MSE C 172 -1 0 LEU C 171 N PHE C 179

SHEET 3 CC 3 ASP C 222 ALA C 224 -1 0 ASP C 222 N MSE C 172

SSBOND 1 CYS A 41 CYS ; A 73 1555 1555 2 , .02

SSBOND 2 CYS A 47 CYS ; c 64 1555 1555 2. .05

SSBOND 3 CYS A 64 CYS ; B 47 1555 1555 2. .06

SSBOND 4 CYS A 81 CYS ; A 243 1555 1555 2. .13

SSBOND 5 CYS A 151 CYS ; A 196 1555 1555 2. .04

SSBOND 6 CYS B 41 CYS ; B 73 1555 1555 2. .02

SSBOND 7 CYS B 64 CYS ; c 47 1555 1555 2 , .07

SSBOND 8 CYS B 81 CYS ; B 243 1555 1555 2. .16

SSBOND 9 CYS B 151 CYS ; B 196 1555 1555 2. .04

SSBOND 10 CYS C 41 CYS ; c 73 1555 1555 2 , .03

SSBOND 11 CYS C 81 CYS ; c 243 1555 1555 2. .06

SSBOND 12 CYS C 151 CYS ; c 196 1555 1555 2. .03

LINK N MSE A 75 c ASN A 74 1555 1555 1. .33

LINK c MSE A 75 N GLU A 76 1555 1555 1. .33

LINK N MSE A 111 c SER A 110 1555 1555 1. .32

LINK c MSE A 111 N ASP A 112 1555 1555 1. .33

LINK N MSE A 158 c TYR A 157 1555 1555 1. .33

LINK C MSE A 158 N ASP A 159 1555 1555 1. .33 LINK N MSE A 172 C LEU A 171 1555 1555 1..33

LINK C MSE A 172 N GLY A 173 1555 1555 1. .33

LINK CA CA A 246 O HOH A2025 1555 1555 2. .41

LINK CA CA A 246 OD1 ASP A 59 1555 1555 2. .48

LINK CA CA A 246 OD2 ASP A 59 1555 1555 2. .49

LINK CA CA A 246 OD1 ASN A 61 1555 1555 2. .33

LINK CA CA A 246 O GLN A 62 1555 1555 2. .29

LINK CA CA A 246 O CYS A 64 1555 1555 2. .33

LINK CA CA A 246 OD1 ASP A 67 1555 1555 2. .32

LINK N MSE B 75 C ASN B 74 1555 1555 1. .33

LINK C MSE B 75 N GLU B 76 1555 1555 1 , .33

LINK C MSE B 111 N ASP B 112 1555 1555 1. .33

LINK N MSE B 111 C SER B 110 1555 1555 1. .33

LINK C MSE B 158 N ASP B 159 1555 1555 1. .31

LINK N MSE B 158 C TYR B 157 1555 1555 1. .33

LINK N AMSE B 172 C LEU B 171 1555 1555 1. .33

LINK N BMSE B 172 C LEU B 171 1555 1555 1. .33

LINK C BMSE B 172 N GLY B 173 1555 1555 1. .33

LINK C AMSE B 172 N GLY B 173 1555 1555 1. .33

LINK CA CA B 246 O HOH B2021 1555 1555 2. .47

LINK CA CA B 246 O GLN B 62 1555 1555 2. .18

LINK CA CA B 246 O CYS B 64 1555 1555 2. .34

LINK CA CA B 246 OD1 ASN B 61 1555 1555 2. .26

LINK CA CA B 246 OD2 ASP B 59 1555 1555 2. .39

LINK CA CA B 246 OD1 ASP B 59 1555 1555 2. .37

LINK CA CA B 246 OD1 ASP B 67 1555 1555 2. .34

LINK C MSE C 75 N GLU C 76 1555 1555 1. .32

LINK N MSE C 75 C ASN C 74 1555 1555 1. .33

LINK N MSE C 111 C SER C 110 1555 1555 1. .33

LINK C MSE C 111 N ASP C 112 1555 1555 1. .34

LINK N MSE C 158 C TYR C 157 1555 1555 1. .33

LINK C MSE C 158 N ASP C 159 1555 1555 1. .33

LINK N MSE C 172 C LEU C 171 1555 1555 1. .32

LINK C MSE C 172 N GLY C 173 1555 1555 1. .32

LINK CA CA C 246 O HOH A2012 1555 1555 2. .47

LINK CA CA C 246 OD1 ASN C 61 1555 1555 2 , .19

LINK CA CA C 246 OD1 ASP C 67 1555 1555 2. .32

LINK CA CA C 246 O CYS C 64 1555 1555 2. .30

LINK CA CA C 246 O GLN C 62 1555 1555 2. .27

LINK CA CA C 246 OD2 ASP C 59 1555 1555 2. .45

LINK CA CA C 246 OD1 ASP C 59 1555 1555 2. .46

CISPEP 1 ASN A 85 PRO A 86 0 -8.26

CISPEP 2 LEU A 218 PRO A 219 0 1.89

CISPEP 3 ASN B 85 PRO B 86 0 -4.93

CISPEP 4 LEU B 218 PRO B 219 0 -0.39

CISPEP 5 ASN C 85 PRO C 86 0 -2.60

CISPEP 6 LEU C 218 PRO C 219 0 6.37

CISPEP 7 ILE C 228 GLY C 229 0 -17.38

SITE 1 AC1 6 ASP A 59 ASN A 61 GLN A 62 CYS A 64

SITE 2 AC1 6 ASP A 67 HOH A2025

SITE 1 AC2 6 PHE A 72 ASN A 74 GLU A 79 CYS A 81

SITE 2 AC2 6 HOH A2052 LEU B 192

SITE 1 AC3 6 LYS A 52 SER A 53 HOH A2018 TYR B 157

SITE 2 AC3 6 THR B 190 VAL B 191

SITE 1 AC4 7 LEU A . 192 GLU A 193 GOL A1249 GOL A1250

SITE 2 AC4 7 HOH A2068 PRO B 241 HOH B2055

SITE 1 AC5 7 GLU A . 193 LYS A 205 GOL A1248 ILE B 147

SITE 2 AC5 7 THR B 148 ASP B 238 GLY B 240

SITE 1 AC6 6 LEU A . 192 GOL A1248 PHE B 72 ASN B 74

SITE 2 AC6 6 GLU B 79 CYS B 81

SITE 1 AC7 6 ASP B 59 ASN B 61 GLN B 62 CYS B 64 SITE 2 .AC7 6 ASP B 67 HOH B2021

SITE 1 . AC8 6 SER B 118 TYR B 119 GLU B 126 LEU B 129

SITE 2 . AC8 6 ASP B 130 LEU B 133

SITE 1 . AC9 9 HIS B 104 LYS B 180 ALA B 181 GLU B 182

SITE 2 . AC9 9 HOH B2033 HOH B2045 HOH B2061 HOH B2063

SITE 3 . AC9 9 HOH B2076

SITE 1 BC1 6 HOH A2012 ASP C 59 ASN C 61 GLN C 62

SITE 2 BC1 6 CYS C 64 ASP C 67

CRYST1 83 .930 89. 27C 1 101. 460 90.00 90.00 90.00 P 21 : 21 : 21 8

0RIGX1 1.000000 0. 000000 0. 000000 0. 00000

ORIGX2 0.000000 1. 000000 0. 000000 0. 00000

ORIGX3 0.000000 0. 000000 1. 000000 0. 00000

SCALE1 0.011915 0. 000000 0. 000000 0. 00000

SCALE2 0.000000 0. 011202 0. 000000 0. 00000

SCALE3 0.000000 0. 000000 0. 009856 0. 00000

ATOM 1 N SER A 29 -25 .815 6. 424 33 .605 1 .00 58 .01 N

ATOM 2 CA SER A 29 -24 .645 5. 861 32 .868 1 .00 61 .67 C

ATOM 3 c SER A 29 -23 .546 5. 376 33 .836 1 .00 59 .27 C

ATOM 4 0 SER A 29 -23 .529 5. 785 34 .995 1 .00 63 .34 O

ATOM 5 CB SER A 29 -24 .102 6. 885 31 .855 1 .00 65 .70 C

ATOM 6 OG SER A 29 -23 .575 8. 039 32 .490 1 .00 66 .55 O

ATOM 7 N PRO A 30 -22 .634 4. 495 33 .367 1 .00 53 .92 N

ATOM 8 CA PRO A 30 -21 .641 3. 874 34 .251 1 .00 50 .09 C

ATOM 9 C PRO A 30 -20 .841 4. 853 35 .120 1 .00 47 .17 C

ATOM 10 O PRO A 30 -20 .500 5. 946 34 .683 1 .00 48 .41 O

ATOM 11 CB PRO A 30 -20 .720 3. 146 33 .272 1 .00 49 .45 C

ATOM 12 CG PRO A 30 -21 .604 2. 801 32 .132 1 .00 49 .21 c

ATOM 13 CD PRO A 30 -22 .511 3. 989 31 .985 1 .00 53 .10 c

ATOM 14 N ASP A 31 -20 .545 4. 455 36 .349 1 .00 42 .09 N

ATOM 15 CA ASP A 31 -19 .939 5. 383 37 .279 1 .00 39 .70 C

ATOM 16 C ASP A 31 -18 .473 5. 101 37 .615 1 .00 35 .56 C

ATOM 17 O ASP A 31 -17 .861 5. 869 38 .334 1 .00 37 .17 O

ATOM 18 CB ASP A 31 -20 .817 5. 564 38 .538 1 .00 39 .36 c

ATOM 19 CG ASP A 31 -20 .923 4. 310 39 .385 1 .00 40 .83 c

ATOM 20 OD1 ASP A 31 -20 .256 3. 292 39 .087 1 .00 39 .89 0

ATOM 21 OD2 ASP A 31 -21 .683 4. 352 40 .380 1 .00 42 .29 0

ATOM 22 N GLY A 32 -17 .913 4. 014 37 .088 1 .00 32 .96 N

ATOM 23 CA GLY A 32 -16 .493 3. 722 37 .280 1 .00 29 .36 C

ATOM 24 C GLY A 32 -16 .188 2. 884 38 .508 1 .00 28 .75 C

ATOM 25 O GLY A 32 -15 .014 2. 653 38 .853 1 .00 26 .09 0

ATOM 26 N SER A 33 -17 .242 2. 435 39 .183 1 .00 29 .16 N

ATOM 27 CA SER A 33 -17 .107 1. 465 40 .280 1 .00 29 .84 C

ATOM 28 C SER A 33 -16 .833 0. 102 39 .663 1 .00 28 .82 C

ATOM 29 O SER A 33 -17 .051 -0. 097 38 .453 1 .00 27 .18 O

ATOM 30 CB SER A 33 -18 .413 1. 384 41 .086 1 .00 32 .34 C

ATOM 31 OG SER A 33 -19 .528 1. 145 40 .222 1 .00 31 .51 0

ATOM 32 N ARG A 34 -16 .364 -0. 825 40 .490 1 .00 27 .39 N

ATOM 33 CA ARG A 34 -16 .131 -2. 197 40 .062 1 .00 28 .70 C

ATOM 34 C ARG A 34 -17 .356 -2. 848 39 .426 1 .00 29 .33 C

ATOM 35 O ARG A 34 -17 .220 -3. 545 38 .434 1 .00 28 .78 O

ATOM 36 CB ARG A 34 -15 .626 -3. 044 41 .230 1 .00 29 .37 c

ATOM 37 CG ARG A 34 -15 .198 -4. 446 40 .842 1 .00 30 .15 c

ATOM 38 CD ARG A 34 -14 .407 -5. 101 41 .972 1 .00 30 .48 c

ATOM 39 NE ARG A 34 -13 .721 -6. 304 41 .510 1 .00 32 .78 N

ATOM 40 CZ ARG A 34 -12 .812 -6. 975 42 .215 1 .00 35 .88 C

ATOM 41 NH1 ARG A 34 -12 .457 -6. 566 43 .432 1 .00 35 .42 N

ATOM 42 NH2 ARG A 34 -12 .245 -8. 057 41 .697 1 .00 36 .14 N

ATOM 43 N LYS A 35 -18 .545 -2. 621 39 .990 1 .00 30 .70 N

ATOM 44 CA LYS A 35 -19 .771 -3. 258 39 .482 1 .00 33 .28 C

ATOM 45 C LYS A 35 -20 .341 -2. 521 38 .287 1 .00 31 .89 C

ATOM 46 O LYS A 35 -21 .132 -3. 067 37 .533 1 .00 33 .85 O ATOM 47 CB LYS A 35 -20..849 -3., 373 40., 581 1..00 36., 52 C

ATOM 48 CG LYS A 35 -20. .610 -4. ,496 41. , 586 1. .00 39. , 35 C

ATOM 49 CD LYS A 35 -21. .516 -4. , 356 42. ,811 1. .00 39. , 39 C

ATOM 50 N ASN A 36 -19. .938 -1. , 276 38. , 104 1. .00 30. , 65 N

ATOM 51 CA ASN A 36 -20. .431 -0. , 488 36. , 985 1. .00 29. , 85 C

ATOM 52 C ASN A 36 -19. .282 0. .265 36. .266 1 , .00 27. .87 C

ATOM 53 O ASN A 36 -19. .200 1. .484 36. .331 1 , .00 26. .91 O

ATOM 54 CB ASN A 36 -21. .493 0. .466 37. .528 1 , .00 33. .02 C

ATOM 55 CG ASN A 36 -22. .316 1. .126 36. .441 1 , .00 37. .18 c

ATOM 56 OD1 ASN A 36 -22. .280 0. ,719 35. , 280 1. .00 42. , 92 0

ATOM 57 ND2 ASN A 36 -23. .064 2. .162 36. .814 1 , .00 36. .95 N

ATOM 58 N PRO A 37 -18. .365 -0. ,467 35. , 606 1. .00 26. , 02 N

ATOM 59 CA PRO A 37 -17. .225 0. .227 34. .970 1. .00 24. , 03 C

ATOM 60 C PRO A 37 -17. .582 1. .077 33. .744 1 , .00 24. .83 C

ATOM 61 O PRO A 37 -18. .502 0. .743 32. .989 1 , .00 24. .40 O

ATOM 62 CB PRO A 37 -16. .297 -0. , 918 34. , 560 1. .00 23. , 31 C

ATOM 63 CG PRO A 37 -17. .209 -2. , 104 34. , 399 1. .00 25. ,11 C

ATOM 64 CD PRO A 37 -18. .256 -1. , 936 35. , 475 1. .00 25. , 10 C

ATOM 65 N ALA A 38 -16. .861 2. .181 33. .577 1 , .00 22. .73 N

ATOM 66 CA ALA A 38 -16. .942 2. .997 32. .380 1 , .00 23. .02 C

ATOM 67 C ALA A 38 -16. .033 2. .379 31. .313 1 , .00 22. .50 C

ATOM 68 O ALA A 38 -15. .133 1. .601 31. .632 1 , .00 23. .18 O

ATOM 69 CB ALA A 38 -16. .513 4. .424 32. .687 1 , .00 22. .41 C

ATOM 70 N ARG A 39 -16. .264 2. .710 30. .051 1 , .00 22. .44 N

ATOM 71 CA ARG A 39 -15. .419 2. .189 28. .975 1 , .00 22. .84 C

ATOM 72 C ARG A 39 -13. .946 2. .589 29. .161 1 , .00 23. .18 C

ATOM 73 O ARG A 39 -13. .044 1. .768 28. .961 1 , .00 23. .13 O

ATOM 74 CB ARG A 39 -15. .930 2. .672 27. .629 1 , .00 23. .36 C

ATOM 75 CG ARG A 39 -15. .233 2. .055 26. .420 1 , .00 23. .91 c

ATOM 76 CD ARG A 39 -15. .791 2. .665 25. .148 1 , .00 24. .21 c

ATOM 77 NE ARG A 39 -15. .507 4. .101 25. .076 1 , .00 24. .93 N

ATOM 78 CZ ARG A 39 -14. .418 4. , 622 24. , 511 1. .00 27. ,21 C

ATOM 79 NH1 ARG A 39 -13. .493 3. .829 23. .965 1 , .00 24. .79 N

ATOM 80 NH2 ARG A 39 -14. .248 5. .944 24. .487 1 , .00 26. .77 N

ATOM 81 N ASN A 40 -13. .719 3. .850 29. .539 1. .00 22. , 17 N

ATOM 82 CA ASN A 40 -12. .378 4. .391 29. .819 1 , .00 20. .81 C

ATOM 83 C ASN A 40 -12. .501 5. .720 30. .577 1 , .00 21. .19 C

ATOM 84 O ASN A 40 -13. .615 6. .189 30. .830 1 , .00 21. .02 O

ATOM 85 CB ASN A 40 -11. .514 4. .498 28. .541 1 , .00 20. .88 C

ATOM 86 CG ASN A 40 -11. .976 5. .593 27. .580 1 , .00 21. .84 C

ATOM 87 OD1 ASN A 40 -12. .840 6. .427 27. .902 1 , .00 21. .78 O

ATOM 88 ND2 ASN A 40 -11. .381 5. .609 26. .392 1 , .00 20. .57 N

ATOM 89 N CYS A 41 -11. .382 6. .327 30. .969 1 , .00 20. .78 N

ATOM 90 CA CYS A 41 -11. .473 7. .527 31. .790 1 , .00 20. .79 C

ATOM 91 C CYS A 41 -12. .073 8. .713 31. .023 1 , .00 21. .54 C

ATOM 92 O CYS A 41 -12. .759 9. .560 31. .615 1 , .00 20. .39 O

ATOM 93 CB CYS A 41 -10. .121 7. .878 32. .392 1 , .00 19. .46 C

ATOM 94 SG CYS A 41 -9. .520 6. .580 33. .486 1 , .00 18. .36 S

ATOM 95 N ARG A 42 -11. .834 8. .746 29. .712 1 , .00 21. .73 N

ATOM 96 CA ARG A 42 -12. .302 9. .832 28. .855 1 , .00 23. .15 C

ATOM 97 C ARG A 42 -13. .828 9. .872 28. .798 1 , .00 24. .64 C

ATOM 98 O ARG A 42 -14. .428 10. .936 28. .895 1 , .00 24. .09 O

ATOM 99 CB ARG A 42 -11. .703 9. .742 27. .437 1 , .00 22. .62 C

ATOM 100 CG ARG A 42 -11. .987 10. .960 26. .576 1 , .00 23. .94 c

ATOM 101 CD ARG A 42 -11. .245 12. .143 27. .181 1 , .00 24. .30 c

ATOM 102 NE ARG A 42 -11. .589 13. .455 26. .652 1 , .00 25. .61 N

ATOM 103 CZ ARG A 42 -12. .624 14. .193 27. .043 1 , .00 25. .52 C

ATOM 104 NH1 ARG A 42 -13. .498 13. .730 27. .918 1 , .00 27. .12 N

ATOM 105 NH2 ARG A 42 -12. .796 15. .399 26. .527 1 , .00 26. .52 N

ATOM 106 N ASP A 43 -14. .440 8. , 703 28. , 650 1. .00 26. , 36 N

ATOM 107 CA ASP A 43 -15. .889 8. .577 28. .728 1 , .00 28. .17 C ATOM 108 C ASP A 43 -16..423 8..965 30..078 1..00 29..73 C

ATOM 109 O ASP A 43 -17. .472 9. .596 30. .164 1. , 00 32. , 10 O

ATOM 110 CB ASP A 43 -16. .323 7. .143 28. .475 1. .00 28. .80 C

ATOM 111 CG ASP A 43 -16. .315 6. .786 27. .023 1. .00 28. .72 C

ATOM 112 OD1 ASP A 43 -15. .517 7. .366 26. .260 1. .00 30. .27 O

ATOM 113 OD2 ASP A 43 -17. .109 5. .913 26. .648 1. .00 31. .22 O

ATOM 114 N LEU A 44 -15. .722 8. .550 31. .127 1. .00 29. .29 N

ATOM 115 CA LEU A 44 -16. .146 8. .825 32. .492 1. .00 29. .51 C

ATOM 116 C LEU A 44 -16. .111 10. .332 32. .783 1. .00 30. .23 C

ATOM 117 O LEU A 44 -16. .998 10. .852 33. .451 1. .00 32. .02 O

ATOM 118 CB LEU A 44 -15. .297 8. .019 33. .490 1. .00 29. .43 C

ATOM 119 CG LEU A 44 -15. .795 7. .951 34. .937 1. .00 29. .91 c

ATOM 120 CD1 LEU A 44 -17. .119 7. .201 35. .045 1. .00 29. .76 c

ATOM 121 CD2 LEU A 44 -14. .741 7. .318 35. .824 1. .00 29. .28 c

ATOM 122 N LYS A 45 -15. .095 11. .023 32. .272 1. .00 28. .73 N

ATOM 123 CA LYS A 45 -15. .019 12. .470 32. .346 1. .00 30. .35 C

ATOM 124 C LYS A 45 -16. .178 13. .131 31. .597 1. .00 33. .99 C

ATOM 125 O LYS A 45 -16. .788 14. .079 32. .094 1. .00 34. .35 O

ATOM 126 CB LYS A 45 -13. .682 12. .955 31. .774 1. .00 30. .16 c

ATOM 127 CG LYS A 45 -13. .479 14. .471 31. .748 1. .00 29. .23 c

ATOM 128 CD LYS A 45 -12. .115 14. .822 31. .159 1. .00 28. .51 c

ATOM 129 CE LYS A 45 -12. .035 16. .280 30. .726 1. .00 29. .56 c

ATOM 130 NZ LYS A 45 -12. .102 17. .207 31. .875 1. .00 29. .13 N

ATOM 131 N PHE A 46 -16. .466 12. .625 30. .401 1. .00 32. .73 N

ATOM 132 CA PHE A 46 -17. .513 13. .169 29. .565 1. .00 35. .10 C

ATOM 133 C PHE A 46 -18. .885 13. .055 30. .200 1. .00 36. .66 C

ATOM 134 O PHE A 46 -19. .662 14. .005 30. .179 1. .00 37. .99 O

ATOM 135 CB PHE A 46 -17. .536 12. .455 28. .216 1. .00 34. .72 C

ATOM 136 CG PHE A 46 -17. .733 13. .381 27. .071 1. .00 36. .40 C

ATOM 137 CD1 PHE A 46 -18. .961 14. .000 26. .866 1. .00 38. .20 C

ATOM 138 CD2 PHE A 46 -16. .689 13. .669 26. .216 1. .00 37. .10 c

ATOM 139 CE1 PHE A 46 -19. .147 14. .868 25. .807 1. .00 38. .08 c

ATOM 140 CE2 PHE A 46 -16. .862 14. , 543 25. ,162 1. , 00 36. , 94 c

ATOM 141 CZ PHE A 46 -18. .090 15. .142 24. .958 1. .00 38. .49 c

ATOM 142 N CYS A 47 -19. .156 11. .883 30. .768 1. .00 37. .38 N

ATOM 143 CA CYS A 47 -20. .458 11. .516 31. .311 1. , 00 37. , 34 C

ATOM 144 C CYS A 47 -20. .634 11. .943 32. .791 1. .00 39. .61 C

ATOM 145 O CYS A 47 -21. .765 12. .002 33. .292 1. .00 40. .52 0

ATOM 146 CB CYS A 47 -20. .664 9. .990 31. .139 1. .00 36. .97 c

ATOM 147 SG CYS A 47 -21. .792 9. .405 29. .831 1. .00 39. .32 s

ATOM 148 N HIS A 48 -19. .527 12. .218 33. .491 1. .00 39. .65 N

ATOM 149 CA HIS A 48 -19. .551 12. .624 34. .907 1. .00 36. .36 C

ATOM 150 C HIS A 48 -18. .509 13. .678 35. .195 1. .00 34. .80 C

ATOM 151 O HIS A 48 -17. .490 13. .401 35. .847 1. .00 32. .75 O

ATOM 152 CB HIS A 48 -19. .308 11. .429 35. .820 1. .00 40. .96 c

ATOM 153 CG HIS A 48 -20. .483 10. .492 35. .961 1. .00 46. .59 c

ATOM 154 ND1 HIS A 48 -20. .851 9. .633 34. .984 1. .00 49. .71 N

ATOM 155 CD2 HIS A 48 -21. .351 10. .263 37. .035 1. .00 48. .17 C

ATOM 156 CE1 HIS A 48 -21. .915 8. .908 35. .402 1. .00 51. .82 C

ATOM 157 NE2 HIS A 48 -22. .218 9. .294 36. .658 1. .00 49. .70 N

ATOM 158 N PRO A 49 -18. .742 14. .920 34. .744 1. .00 34. .67 N

ATOM 159 CA PRO A 49 -17. .662 15. .902 34. .860 1. .00 33. .88 C

ATOM 160 C PRO A 49 -17. .358 16. .288 36. .314 1. .00 33. .79 C

ATOM 161 O PRO A 49 -16. .389 16. .994 36. .560 1. .00 32. .38 O

ATOM 162 CB PRO A 49 -18. .185 17. ,118 34. , 074 1. , 00 33. , 84 C

ATOM 163 CG PRO A 49 -19. .485 16. .702 33. .451 1. .00 34. .07 C

ATOM 164 CD PRO A 49 -19. .987 15. .521 34. .234 1. .00 35. .26 C

ATOM 165 N GLU A 50 -18. .170 15. .813 37. .257 1. , 00 33. , 87 N

ATOM 166 CA GLU A 50 -17. .973 16. .121 38. .675 1. .00 34. .24 C

ATOM 167 C GLU A 50 -16. .958 15. .196 39. .332 1. .00 32. .57 C

ATOM 168 O GLU A 50 -16. .426 15. .496 40. .394 1. .00 32. .88 O ATOM 169 CB GLU A 50 -19..308 16..089 39..447 1..00 35..49 C

ATOM 170 CG GLU A 50 -19. .832 14. .701 39. .798 1. .00 38. .47 C

ATOM 171 CD GLU A 50 -20. .433 13. .961 38. .610 1. .00 42. .32 C

ATOM 172 OE1 GLU A 50 -20. .564 14. .567 37. .524 1. .00 44. .22 O

ATOM 173 OE2 GLU A 50 -20. .790 12. .769 38. .766 1. .00 45. .04 O

ATOM 174 N LEU A 51 -16. .687 14. .061 38. .710 1. .00 32. .40 N

ATOM 175 CA LEU A 51 -15. .767 13. .113 39. .321 1. .00 30. .00 C

ATOM 176 C LEU A 51 -14. .324 13. .640 39. .294 1. .00 28. .36 C

ATOM 177 O LEU A 51 -13. .920 14. .357 38. .371 1. .00 28. .74 O

ATOM 178 CB LEU A 51 -15. .906 11. .716 38. .692 1. .00 30. .77 C

ATOM 179 CG LEU A 51 -17. .162 10. .898 39. .056 1. .00 30. .33 c

ATOM 180 CD1 LEU A 51 -17. .229 9. .637 38. .208 1. .00 31. .15 c

ATOM 181 CD2 LEU A 51 -17. .246 10. .545 40. .541 1. .00 28. .50 c

ATOM 182 N LYS A 52 -13. .565 13. .302 40. .324 1. .00 26. .35 N

ATOM 183 CA LYS A 52 -12. .229 13. .820 40. .478 1. .00 26. .66 C

ATOM 184 C LYS A 52 -11. .204 12. .733 40. .216 1. .00 26. .36 C

ATOM 185 O LYS A 52 -11. .551 11. .542 40. .228 1. .00 23. .94 O

ATOM 186 CB LYS A 52 -12. .074 14. .410 41. .873 1. .00 28. .50 c

ATOM 187 CG LYS A 52 -12. .529 15. .872 41. .918 1. .00 31. .71 c

ATOM 188 CD LYS A 52 -12. .907 16. .307 43. .316 1. .00 33. .86 c

ATOM 189 CE LYS A 52 -12. .993 17. .828 43. .413 1. .00 37. .18 c

ATOM 190 NZ LYS A 52 -14. .138 18. , 407 42. , 655 1. , 00 39. , 65 N

ATOM 191 N SER A 53 -9. .951 13. .141 39. .992 1. .00 23. .00 N

ATOM 192 CA SER A 53 -8. .903 12. .211 39. .614 1. .00 22. .72 C

ATOM 193 C SER A 53 -8. .719 11. .159 40. .690 1. , 00 23. , 57 C

ATOM 194 O SER A 53 -8. .734 11. .481 41. .883 1. .00 23. .17 O

ATOM 195 CB SER A 53 -7. .591 12. .942 39. .328 1. .00 20. .79 C

ATOM 196 OG SER A 53 -7. .767 13. .797 38. .208 1. .00 20. .11 O

ATOM 197 N GLY A 54 -8. .572 9. .902 40. .270 1. .00 21. .51 N

ATOM 198 CA GLY A 54 -8. .393 8. .810 41. .221 1. .00 22. .45 C

ATOM 199 C GLY A 54 -8. .635 7. .436 40. .633 1. .00 23. .86 C

ATOM 200 O GLY A 54 -8. .726 7. .269 39. .409 1. .00 23. .07 O

ATOM 201 N GLU A 55 -8. .740 6. .458 41. .522 1. .00 23. .36 N

ATOM 202 CA GLU A 55 -8. .901 5. .071 41. .153 1. .00 23. .96 C

ATOM 203 C GLU A 55 -10. .327 4. .797 40. .660 1. .00 23. .57 C

ATOM 204 O GLU A 55 -11. .307 5. .137 41. .338 1. .00 23. .27 O

ATOM 205 CB GLU A 55 -8. .488 4. .177 42. .333 1. .00 25. .83 C

ATOM 206 CG GLU A 55 -8. .757 2. .687 42. .161 1. .00 30. .64 c

ATOM 207 CD GLU A 55 -8. .027 1. .827 43. .193 1. .00 33. .23 c

ATOM 208 OE1 GLU A 55 -6. .825 1. .549 43. .014 1. .00 35. .09 0

ATOM 209 OE2 GLU A 55 -8. .653 1. .417 44. .192 1. .00 38. .33 0

ATOM 210 N TYR A 56 -10. .437 4. .245 39. .447 1. .00 22. .04 N

ATOM 211 CA TYR A 56 -11. .706 3. .746 38. .917 1. .00 21. .73 C

ATOM 212 C TYR A 56 -11. .536 2. .414 38. .170 1. .00 22. .13 C

ATOM 213 O TYR A 56 -10. .414 1. .937 37. .963 1. .00 21. .22 0

ATOM 214 CB TYR A 56 -12. .346 4. .749 37. .969 1. .00 21. .75 c

ATOM 215 CG TYR A 56 -12. .674 6. .077 38. .599 1. .00 21. .63 c

ATOM 216 CD1 TYR A 56 -11. .737 7. .096 38. .614 1. .00 21. .23 c

ATOM 217 CD2 TYR A 56 -13. .922 6. .314 39. .177 1. .00 21. .31 c

ATOM 218 CE1 TYR A 56 -12. .021 8. .329 39. .189 1. .00 22. .73 c

ATOM 219 CE2 TYR A 56 -14. .218 7. .537 39. .765 1. .00 21. .38 c

ATOM 220 CZ TYR A 56 -13. .252 8. .546 39. .763 1. .00 21. .88 c

ATOM 221 OH TYR A 56 -13. .510 9. .778 40. .315 1. .00 23. .38 0

ATOM 222 N TRP A 57 -12. .669 1. .824 37. .790 1. .00 20. .85 N

ATOM 223 CA TRP A 57 -12. .698 0. .595 37. .019 1. .00 21. .05 c

ATOM 224 C TRP A 57 -13. .187 0. .925 35. .653 1. .00 20. .41 c

ATOM 225 O TRP A 57 -14. .200 1. .602 35. .501 1. .00 20. .11 0

ATOM 226 CB TRP A 57 -13. .605 -0. , 442 37. , 670 1. , 00 22. , 64 c

ATOM 227 CG TRP A 57 -13. .026 -0. , 981 38. , 948 1. , 00 23. , 44 c

ATOM 228 CD1 TRP A 57 -13. .031 -0. , 374 40. , 209 1. , 00 23. , 40 c

ATOM 229 CD2 TRP A 57 -12. .319 -2. , 253 39. , 136 1. , 00 24. ,09 c ATOM 230 NE1 TRP A 57 -12..392 -1..165 41..122 1..00 24..30 N

ATOM 231 CE2 TRP A 57 -11. .936 -2. .300 40. .552 1. .00 23. .89 C

ATOM 232 CE3 TRP A 57 -11. .965 -3. .314 38. .304 1. .00 23. .77 C

ATOM 233 CZ2 TRP A 57 -11. .252 -3. .385 41. .095 1. .00 24. .56 C

ATOM 234 CZ3 TRP A 57 -11. .278 -4. .401 38. .865 1. .00 23. .28 C

ATOM 235 CH2 TRP A 57 -10. .933 -4. .434 40. .226 1. .00 23. .39 C

ATOM 236 N VAL A 58 -12. .439 0 , .487 34 , .644 1 , .00 19, .96 N

ATOM 237 CA VAL A 58 -12. .827 0 , .714 33, .263 1 , .00 19, .60 C

ATOM 238 C VAL A 58 -12. .822 -0. .610 32. .517 1. .00 20. .06 C

ATOM 239 O VAL A 58 -12. .162 -1. .579 32. .940 1. .00 20. .10 O

ATOM 240 CB VAL A 58 -11. .913 1 , .746 32 , .555 1 , .00 19, .84 C

ATOM 241 CGI VAL A 58 -11. .905 3, .091 33, .303 1 , .00 19, .66 C

ATOM 242 CG2 VAL A 58 -10. .493 1 , .208 32 , .400 1 , .00 17 , .56 c

ATOM 243 N ASP A 59 -13. .567 -0. .652 31. .416 1. .00 20. .72 N

ATOM 244 CA ASP A 59 -13. .765 -1. .884 30. .655 1. .00 20. .52 C

ATOM 245 C ASP A 59 -13. .723 -1. .602 29. .158 1. .00 18. .59 C

ATOM 246 O ASP A 59 -14. .754 -1. .526 28. .526 1. .00 18. .34 O

ATOM 247 CB ASP A 59 -15. .113 -2. .498 31. .023 1. .00 22. .46 c

ATOM 248 CG ASP A 59 -15. .251 -3. .920 30. .536 1. .00 23. .43 c

ATOM 249 OD1 ASP A 59 -14. .225 -4. .619 30. .439 1. .00 24. .63 0

ATOM 250 OD2 ASP A 59 -16. .380 -4. .352 30. .251 1. .00 24. .53 0

ATOM 251 N PRO A 60 -12. .518 -1. .436 28. .599 1. .00 18. .44 N

ATOM 252 CA PRO A 60 -12. .371 -0. .967 27. .213 1. .00 17. .96 C

ATOM 253 C PRO A 60 -13. .021 -1. .913 26. .207 1. .00 18. .56 C

ATOM 254 O PRO A 60 -13. .575 -1. .466 25. .225 1. .00 17. .41 O

ATOM 255 CB PRO A 60 -10. .855 -0. .935 27. .002 1. .00 17. .80 c

ATOM 256 CG PRO A 60 -10. .268 -0. .831 28. .391 1. .00 18. .30 c

ATOM 257 CD PRO A 60 -11. .227 -1. .513 29. .319 1. .00 17. .72 c

ATOM 258 N ASN A 61 -12. .974 -3. .210 26. .465 1. .00 19. .10 N

ATOM 259 CA ASN A 61 -13. .540 -4. .149 25. .519 1. .00 19. .98 C

ATOM 260 C ASN A 61 -15. .062 -4. .276 25. .662 1. .00 20. .87 C

ATOM 261 O ASN A 61 -15. .695 -4. .978 24. .869 1. .00 21. .80 O

ATOM 262 CB ASN A 61 -12. .809 -5. .503 25. .569 1. .00 19. .24 c

ATOM 263 CG ASN A 61 -13. .064 -6. .273 26. .869 1. .00 19. .91 c

ATOM 264 OD1 ASN A 61 -13. .902 -5. .877 27. .686 1. .00 19. .55 0

ATOM 265 ND2 ASN A 61 -12. .357 -7. .390 27. .048 1. .00 18. .20 N

ATOM 266 N GLN A 62 -15. .643 -3. .577 26. .647 1. .00 20. .90 N

ATOM 267 CA GLN A 62 -17. .095 -3. .655 26. .934 1. .00 21. .59 C

ATOM 268 C GLN A 62 -17. .595 -5. .124 27. .038 1. .00 21. .33 C

ATOM 269 O GLN A 62 -16. .939 -5. .949 27. .667 1. .00 21. .38 O

ATOM 270 CB GLN A 62 -17. .916 -2. .818 25. .930 1. .00 20. .94 C

ATOM 271 CG GLN A 62 -17. .627 -1. .323 25. .953 1. .00 21. .36 C

ATOM 272 CD GLN A 62 -18. .219 -0. .624 27. .170 1. .00 21. .72 C

ATOM 273 OE1 GLN A 62 -19. .320 -0. .060 27. .125 1. .00 23. .61 0

ATOM 274 NE2 GLN A 62 -17. .507 -0. .669 28. .254 1. .00 21. .31 N

ATOM 275 N GLY A 63 -18. .741 -5. .453 26. .450 1. .00 23. .19 N

ATOM 276 CA GLY A 63 -19. .321 -6. .799 26. .608 1. .00 24. .89 C

ATOM 277 C GLY A 63 -19. .494 -7. .171 28. .078 1. .00 26. .14 C

ATOM 278 O GLY A 63 -20. .049 -6. .393 28. .852 1. .00 25. .42 O

ATOM 279 N CYS A 64 -18. .968 -8. .330 28. .475 1. .00 26. .69 N

ATOM 280 CA CYS A 64 -19. .015 -8. .773 29. .885 1. .00 27. .85 C

ATOM 281 C CYS A 64 -18. .234 -7. .833 30. .843 1. .00 26. .64 C

ATOM 282 O CYS A 64 -17. .060 -7. .519 30. .629 1. .00 22. .96 O

ATOM 283 CB CYS A 64 -18. .539 -10. .240 30. .019 1. .00 30. .12 C

ATOM 284 SG CYS A 64 -18. .366 -10. .971 31. .686 1. .00 30. .47 s

ATOM 285 N LYS A 65 -18. .910 -7. .421 31. .908 1. .00 27. .12 N

ATOM 286 CA LYS A 65 -18. .338 -6. .523 32. .900 1. .00 29. .35 C

ATOM 287 C LYS A 65 -17. .237 -7. .089 33. .774 1. .00 27. .90 C

ATOM 288 O LYS A 65 -16. .510 -6. .329 34. .393 1. .00 28. .52 O

ATOM 289 CB LYS A 65 -19. .438 -5. .910 33. .762 1. .00 32. .02 C

ATOM 290 CG LYS A 65 -19. .925 -4. .606 33. .155 1. .00 36. .94 c ATOM 291 CD LYS A 65 -21..357 -4..249 33..527 1..00 40..67 C

ATOM 292 CE LYS A 65 -21. .940 -3. .314 32. .469 1. .00 42. .70 C

ATOM 293 NZ LYS A 65 -23. .427 -3. .285 32. .534 1. .00 45. .48 N

ATOM 294 N LEU A 66 -17. .075 -8. .411 33. .783 1. .00 26. .64 N

ATOM 295 CA LEU A 66 -16. .247 -9. .075 34. .791 1. .00 26. .55 C

ATOM 296 C LEU A 66 -14. .738 -8. .996 34. .577 1. .00 25. .53 C

ATOM 297 O LEU A 66 -13. .968 -9. .292 35. .489 1. .00 27. .29 O

ATOM 298 CB LEU A 66 -16. .687 -10. .544 34. .963 1. .00 27. .51 C

ATOM 299 CG LEU A 66 -18. .134 -10. .811 35. .411 1. .00 28. .66 C

ATOM 300 CD1 LEU A 66 -18. .378 -12. .308 35. .544 1. .00 31. .60 C

ATOM 301 CD2 LEU A 66 -18. .487 -10. .120 36. .716 1. .00 28. .64 C

ATOM 302 N ASP A 67 -14. .302 -8. .621 33. .381 1. .00 22. .80 N

ATOM 303 CA ASP A 67 -12. .881 -8. .524 33. .130 1. .00 21. .59 C

ATOM 304 C ASP A 67 -12. .394 -7. .078 33. .162 1. .00 20. .89 C

ATOM 305 O ASP A 67 -11. .375 -6. .751 32. .565 1. .00 23. .56 O

ATOM 306 CB ASP A 67 -12. .518 -9. .211 31. .801 1. .00 21. .75 C

ATOM 307 CG ASP A 67 -13. .233 -8. .595 30. .581 1. .00 22. .05 c

ATOM 308 OD1 ASP A 67 -14. .119 -7. .726 30. .737 1. .00 22. .26 0

ATOM 309 OD2 ASP A 67 -12. .905 -9. .002 29. .447 1. .00 22. .61 0

ATOM 310 N ALA A 68 -13. .128 -6. .215 33. .851 1. .00 21. .06 N

ATOM 311 CA ALA A 68 -12. .788 -4. .798 33. .932 1. .00 21. .26 C

ATOM 312 C ALA A 68 -11. .485 -4. .613 34. .689 1. .00 22. .01 C

ATOM 313 O ALA A 68 -11. .118 -5. .444 35. .520 1. .00 21. .10 O

ATOM 314 CB ALA A 68 -13. .921 -4. .005 34. .582 1. .00 21. .75 c

ATOM 315 N ILE A 69 -10. .769 -3. .543 34. .353 1. .00 22. .34 N

ATOM 316 CA ILE A 69 -9. .479 -3. .258 34. .963 1. .00 22. .25 C

ATOM 317 C ILE A 69 -9. .492 -2. .018 35. .860 1. .00 21. .44 C

ATOM 318 O ILE A 69 -10. .313 -1. .105 35. .703 1. .00 20. .53 O

ATOM 319 CB ILE A 69 -8. .351 -3. .166 33. .908 1. .00 22. .93 C

ATOM 320 CGI ILE A 69 -8. .694 -2. .117 32. .851 1. .00 22. .48 c

ATOM 321 CG2 ILE A 69 -8. .111 -4. .544 33. .272 1. .00 23. .13 c

ATOM 322 CD1 ILE A 69 -7. .507 -1. .633 32. .043 1. .00 22. .54 c

ATOM 323 N LYS A 70 -8. .575 -2. .010 36. .815 1. .00 22. .45 N

ATOM 324 CA LYS A 70 -8. .504 -0. .954 37. .819 1. .00 22. .85 C

ATOM 325 C LYS A 70 -7. .463 0 , .021 37 , .332 1 , .00 20 , .98 C

ATOM 326 O LYS A 70 -6. .351 -0. .383 37. .019 1. .00 19. .07 O

ATOM 327 CB LYS A 70 -8. .030 -1. .561 39. .140 1. .00 25. .82 c

ATOM 328 CG LYS A 70 -8. .291 -0. .734 40. .377 1. .00 28. .05 c

ATOM 329 CD LYS A 70 -7. .300 -1. .118 41. .467 1. .00 33. .87 c

ATOM 330 CE LYS A 70 -7. .696 -2. .332 42. .292 1. .00 37. .41 c

ATOM 331 NZ LYS A 70 -6. .573 -2. .679 43. .220 1. .00 39. .34 N

ATOM 332 N VAL A 71 -7. .807 1 , .298 37 , .256 1 , .00 19, .81 N

ATOM 333 CA VAL A 71 -6. .869 2. .263 36. .711 1. .00 20. .33 C

ATOM 334 C VAL A 71 -6. .873 3, .556 37 , .521 1 , .00 20 , .60 C

ATOM 335 O VAL A 71 -7. .749 3, .763 38 , .358 1 , .00 21 , .85 O

ATOM 336 CB VAL A 71 -7. .194 2 , .588 35, .216 1. .00 20. .48 C

ATOM 337 CGI VAL A 71 -7. .175 1 , .326 34 , .350 1 , .00 19, .73 C

ATOM 338 CG2 VAL A 71 -8. .526 3, .322 35, .106 1 , .00 19, .19 C

ATOM 339 N PHE A 72 -5. .907 4 , .430 37 , .248 1 , .00 19, .85 N

ATOM 340 CA PHE A 72 -5. .979 5, .828 37 , .700 1 , .00 19, .83 C

ATOM 341 C PHE A 72 -6. .539 6, .642 36, .553 1 , .00 19, .27 C

ATOM 342 O PHE A 72 -6. .063 6, .509 35, .415 1 , .00 20 , .05 O

ATOM 343 CB PHE A 72 -4. .605 6, .364 38 , .127 1 , .00 19, .74 C

ATOM 344 CG PHE A 72 -4. .602 7 , .842 38 , .464 1 , .00 20 , .56 c

ATOM 345 CD1 PHE A 72 -4. .994 8 , .292 39, .727 1 , .00 20 , .27 c

ATOM 346 CD2 PHE A 72 -4. .209 8 , .792 37 , .513 1 , .00 20 , .51 c

ATOM 347 CE1 PHE A 72 -5. .013 9, .652 40 , .031 1 , .00 21 , .36 c

ATOM 348 CE2 PHE A 72 -4. .226 10 , .149 37 , .823 1 , .00 21 , .57 c

ATOM 349 CZ PHE A 72 -4. .623 10 , .581 39, .086 1 , .00 20 , .78 c

ATOM 350 N CYS A 73 -7. .574 7 , .432 36, .836 1 , .00 18 , .79 N

ATOM 351 CA CYS A 73 -8. .120 8 , .377 35, .869 1 , .00 19, .97 C ATOM 352 C CYS A 73 -7..631 9..777 36..236 1..00 21..23 C

ATOM 353 O CYS A 73 -7. .921 10. .275 37. .322 1. .00 20. .95 O

ATOM 354 CB CYS A 73 -9. .655 8. .407 35. .831 1. .00 18. .65 C

ATOM 355 SG CYS A 73 -10. .504 6. .935 35. .215 1. .00 18. .09 S

ATOM 356 N ASN A 74 -6. .895 10. .401 35. .319 1. .00 22. .23 N

ATOM 357 CA ASN A 74 -6. .647 11. .825 35. .404 1. .00 22. .68 C

ATOM 358 C ASN A 74 -7. .840 12. , 544 34. ,814 1. , 00 22. , 85 C

ATOM 359 O ASN A 74 -7. .994 12. .547 33. .611 1. .00 24. .52 O

ATOM 360 CB ASN A 74 -5. .373 12. .184 34. .642 1. .00 21. .31 C

ATOM 361 CG ASN A 74 -4. .990 13. .635 34. .816 1. , 00 19. , 73 c

ATOM 362 OD1 ASN A 74 -5. .842 14. .519 34. .816 1. .00 19. .96 0

ATOM 363 ND2 ASN A 74 -3. .710 13. .887 34. .944 1. .00 19. .29 N

HETATM 364 N MSE A 75 -8. .669 13. .162 35. .653 1. .00 24. .70 N

HETATM 365 CA MSE A 75 -9. .921 13. .778 35. .196 1. .00 26. .80 C

HETATM 366 C MSE A 75 -9. .739 15. .188 34. .694 1. .00 28. .51 C

HETATM 367 O MSE A 75 -10. .662 15. .767 34. .129 1. .00 29. .09 O

HETATM 368 CB MSE A 75 -11. .035 13. .738 36. .245 1. .00 28. .68 C

HETATM 369 CG MSE A 75 -11. .349 12. .306 36. .668 1. .00 30. .75 C

HETATM 370 SE MSE A 75 -12. .124 11. .315 35. .149 1. .00 35. .40 SE

HETATM 371 CE MSE A 75 -13. .985 11. .743 35. .590 1. .00 37. .21 C

ATOM 372 N GLU A 76 -8. .554 15. .750 34. .885 1. .00 27. .68 N

ATOM 373 CA GLU A 76 -8. .193 16. .955 34. .186 1. .00 29. .23 C

ATOM 374 C GLU A 76 -7. .934 16. .656 32. .693 1. .00 28. .72 C

ATOM 375 O GLU A 76 -8. .463 17. .330 31. .826 1. .00 28. .88 O

ATOM 376 CB GLU A 76 -6. .980 17. .587 34. .867 1. .00 31. .90 C

ATOM 377 CG GLU A 76 -6. .092 18. .434 33. .968 1. .00 38. .58 c

ATOM 378 CD GLU A 76 -6. .641 19. .821 33. .736 1. .00 45. .61 c

ATOM 379 OE1 GLU A 76 -7. .803 20. .103 34. .133 1. .00 45. .62 0

ATOM 380 OE2 GLU A 76 -5. .889 20. .635 33. .155 1. .00 52. .37 0

ATOM 381 N THR A 77 -7. .130 15. .642 32. .386 1. .00 27. .30 N

ATOM 382 CA THR A 77 -6. .766 15. .395 30. .982 1. .00 25. .13 C

ATOM 383 C THR A 77 -7. .682 14. .368 30. .318 1. .00 25. .11 C

ATOM 384 O THR A 77 -7. .763 14. .320 29. .104 1. .00 24. .57 0

ATOM 385 CB THR A 77 -5. .335 14. .879 30. .840 1. .00 24. .33 c

ATOM 386 OG1 THR A 77 -5. .216 13. .654 31. .577 1. .00 23. .02 0

ATOM 387 CG2 THR A 77 -4. .305 15. .919 31. .358 1. .00 23. .57 c

ATOM 388 N GLY A 78 -8. .360 13. .541 31. .114 1. .00 24. .46 N

ATOM 389 CA GLY A 78 -9. .120 12. .409 30. .564 1. .00 22. .84 C

ATOM 390 C GLY A 78 -8. .316 11. .127 30. .330 1. .00 21. .85 C

ATOM 391 O GLY A 78 -8. .835 10. .155 29. .783 1. .00 22. .46 0

ATOM 392 N GLU A 79 -7. .063 11. .093 30. .761 1. .00 20. .35 N

ATOM 393 CA GLU A 79 -6. .220 9. .940 30. .480 1. .00 20. .22 C

ATOM 394 C GLU A 79 -6. .498 8. .735 31. .367 1. .00 19. .81 C

ATOM 395 O GLU A 79 -6. .781 8. , 883 32. , 566 1. , 00 19. ,06 O

ATOM 396 CB GLU A 79 -4. .771 10. .305 30. .642 1. .00 20. .50 C

ATOM 397 CG GLU A 79 -4. .265 11. .394 29. .710 1. .00 21. .42 c

ATOM 398 CD GLU A 79 -2. .906 11. .888 30. .169 1. , 00 22. , 25 c

ATOM 399 OE1 GLU A 79 -2. .858 12. .629 31. .170 1. .00 21. .15 0

ATOM 400 OE2 GLU A 79 -1. .884 11. .495 29. .559 1. .00 24. .33 0

ATOM 401 N THR A 80 -6. .398 7. .544 30. .766 1. .00 19. .23 N

ATOM 402 CA THR A 80 -6. .554 6. .266 31. .461 1. .00 18. .24 C

ATOM 403 C THR A 80 -5. .164 5. .726 31. .733 1. .00 17. .86 C

ATOM 404 O THR A 80 -4. .456 5. .338 30. .803 1. .00 18. .03 0

ATOM 405 CB THR A 80 -7. .332 5. .247 30. .584 1. .00 18. .34 c

ATOM 406 OG1 THR A 80 -8. .597 5. .805 30. .199 1. .00 17. .63 0

ATOM 407 CG2 THR A 80 -7. .542 3. .926 31. .334 1. .00 17. .36 c

ATOM 408 N CYS A 81 -4. .762 5. .694 32. .995 1. .00 18. .25 N

ATOM 409 CA CYS A 81 -3. .380 5. .332 33. .331 1. .00 18. .47 C

ATOM 410 C CYS A 81 -3. .283 3. .962 34. .012 1. .00 19. .59 C

ATOM 411 O CYS A 81 -3. .821 3. .752 35. .106 1. .00 21. .06 0

ATOM 412 CB CYS A 81 -2. .708 6. .451 34. .153 1. .00 17. .40 c ATOM 413 SG CYS A 81 -2..598 8 ,.055 33,.301 1 ,.00 16,.67 S

ATOM 414 N ILE A 82 -2. .593 3, .024 33, .362 1 , .00 20 , .17 N

ATOM 415 CA ILE A 82 -2. .491 1 , .664 33, .889 1 , .00 20 , .33 C

ATOM 416 C ILE A 82 -1. .105 1 , .399 34 , .435 1 , .00 20 , .96 C

ATOM 417 O ILE A 82 -0. .108 1. .531 33. .716 1. .00 20. .27 O

ATOM 418 CB ILE A 82 -2. .838 0 , .614 32 , .807 1 , .00 21 , .66 C

ATOM 419 CGI ILE A 82 -4. .145 1 , .015 32 , .106 1 , .00 20 , .94 c

ATOM 420 CG2 ILE A 82 -2. .953 -0. .777 33. .437 1. .00 20. .66 c

ATOM 421 CD1 ILE A 82 -4. .349 0 , .266 30 , .815 1 , .00 24 , .01 c

ATOM 422 N SER A 83 -1. .057 1 , .033 35, .714 1 , .00 21 , .39 N

ATOM 423 CA SER A 83 0. .204 0 , .756 36, .409 1 , .00 22 , .76 C

ATOM 424 C SER A 83 0. .826 -0. .543 35. .965 1. .00 24. .67 C

ATOM 425 O SER A 83 0. .125 -1. .540 35. .684 1. .00 24. .93 O

ATOM 426 CB SER A 83 0. .003 0 , .713 37 , .919 1 , .00 21 , .33 c

ATOM 427 OG SER A 83 -0. .597 1 , .920 38 , .346 1 , .00 20 , .95 0

ATOM 428 N ALA A 84 2. .145 -0. .512 35. .893 1. .00 25. .90 N

ATOM 429 CA ALA A 84 2. .956 -1. .667 35. .619 1. .00 28. .08 C

ATOM 430 C ALA A 84 2. .964 -2. .589 36. .814 1. .00 30. .74 C

ATOM 431 O ALA A 84 2. .856 -2. .150 37. .945 1. .00 31. .88 O

ATOM 432 CB ALA A 84 4. .364 -1. .246 35. .271 1. .00 26. .61 c

ATOM 433 N ASN A 85 3. .069 -3. .875 36. .542 1. .00 33. .75 N

ATOM 434 CA ASN A 85 3. .237 -4. .862 37. .575 1. .00 38. .10 C

ATOM 435 C ASN A 85 4. .455 -5. .707 37. .298 1. .00 38. .67 C

ATOM 436 O ASN A 85 4. .474 -6. .408 36. .312 1. .00 42. .76 O

ATOM 437 CB ASN A 85 2. .030 -5. .770 37. .578 1. .00 41. .79 C

ATOM 438 CG ASN A 85 1. .589 -6. .121 38. .962 1. .00 47. .16 c

ATOM 439 OD1 ASN A 85 2. .160 -6. .993 39. .597 1. .00 51. .36 0

ATOM 440 ND2 ASN A 85 0. .576 -5. .427 39. .451 1. .00 51. .09 N

ATOM 441 N PRO A 86 5. .448 -5. .707 38. .179 1. .00 37. .97 N

ATOM 442 CA PRO A 86 5. .544 -4. .815 39. .337 1. .00 37. .83 C

ATOM 443 C PRO A 86 5. .923 -3. .384 38. .971 1. .00 37. .18 C

ATOM 444 O PRO A 86 6. .360 -3. .118 37. .865 1. .00 35. .49 O

ATOM 445 CB PRO A 86 6. .663 -5. .445 40. .159 1. .00 36. .64 C

ATOM 446 CG PRO A 86 7. .514 -6. .124 39. .161 1. .00 37. .33 C

ATOM 447 CD PRO A 86 6. .585 -6. .635 38. .104 1. .00 38. .14 C

ATOM 448 N LEU A 87 5. .725 -2. .479 39. .915 1. .00 36. .85 N

ATOM 449 CA LEU A 87 5. .957 -1. .048 39. .714 1. .00 38. .92 C

ATOM 450 C LEU A 87 7. .398 -0. .683 39. .408 1. .00 40. .45 C

ATOM 451 O LEU A 87 7. .669 0 , .318 38 , .728 1 , .00 37 , .26 O

ATOM 452 CB LEU A 87 5. .518 -0. .270 40. .952 1. .00 39. .17 C

ATOM 453 CG LEU A 87 4. .015 -0. .189 41. .233 1. .00 41. .96 c

ATOM 454 CD1 LEU A 87 3. .758 0 , .508 42 , .563 1 , .00 42 , .24 c

ATOM 455 CD2 LEU A 87 3. .270 0 , .514 40 , .100 1 , .00 42 , .10 c

ATOM 456 N ASN A 88 8. .328 -1. .479 39. .923 1. .00 40. .71 N

ATOM 457 CA ASN A 88 9. .733 -1. .132 39. .788 1. .00 40. .97 C

ATOM 458 C ASN A 88 10. .761 -2. .257 39. .825 1. .00 39. .61 C

ATOM 459 O ASN A 88 10. .509 -3. .366 40. .298 1. .00 37. .21 O

ATOM 460 CB ASN A 88 10. .116 -0. .023 40. .789 1. .00 45. .81 c

ATOM 461 CG ASN A 88 10. .007 -0. .458 42. .228 1. .00 46. .05 c

ATOM 462 OD1 ASN A 88 10. .764 -1. .305 42. .695 1. .00 47. .99 0

ATOM 463 ND2 ASN A 88 9. .078 0 , .148 42 , .952 1 , .00 51 , .19 N

ATOM 464 N VAL A 89 11. .928 -1. .924 39. .291 1. .00 38. .75 N

ATOM 465 CA VAL A 89 13. .117 -2. .736 39. .367 1. .00 36. .10 C

ATOM 466 C VAL A 89 13. .936 -2. .180 40. .517 1. .00 36. .79 C

ATOM 467 O VAL A 89 14. .371 -1. .028 40. .455 1. .00 36. .94 O

ATOM 468 CB VAL A 89 13. .921 -2. .628 38. .073 1. .00 32. .85 C

ATOM 469 CGI VAL A 89 15. .208 -3. .418 38. .181 1. .00 33. .65 C

ATOM 470 CG2 VAL A 89 13. .083 -3. .111 36. .905 1. .00 33. .26 C

ATOM 471 N PRO A 90 14. .125 -2. .987 41. .584 1. .00 37. .01 N

ATOM 472 CA PRO A 90 14. .897 -2. .561 42. .745 1. .00 35. .61 C

ATOM 473 C PRO A 90 16. .350 -2. .260 42. .374 1. .00 35. .73 C ATOM 474 O PRO A 90 16..885 -2..860 41..436 1..00 35..71 O

ATOM 475 CB PRO A 90 14. .806 -3. .768 43. .692 1. .00 37. .75 C

ATOM 476 CG PRO A 90 14. .509 -4. .933 42. .804 1. .00 38. .83 C

ATOM 477 CD PRO A 90 13. .619 -4. .367 41. .736 1. .00 37. .93 C

ATOM 478 N ARG A 91 16. .961 -1. .321 43. .094 1. .00 35. .96 N

ATOM 479 CA ARG A 91 18. .357 -0. .929 42. .882 1. .00 39. .49 C

ATOM 480 C ARG A 91 19. .339 -2. .066 43. .174 1. .00 42. .78 C

ATOM 481 O ARG A 91 19. .327 -2. .629 44. .267 1. .00 43. .46 O

ATOM 482 CB ARG A 91 18. .707 0. .267 43. .777 1. .00 39. .24 C

ATOM 483 CG ARG A 91 17. .800 1 , .476 43, .612 1 , .00 40 , .09 C

ATOM 484 CD ARG A 91 18. .251 2 , .670 44 , .434 1 , .00 39, .02 c

ATOM 485 NE ARG A 91 17. .207 3, .685 44 , .421 1. .00 43. .87 N

ATOM 486 CZ ARG A 91 17. .330 4 , .940 44 , .864 1 , .00 45, .90 C

ATOM 487 NH1 ARG A 91 18. .469 5, .388 45, .377 1 , .00 45, .33 N

ATOM 488 NH2 ARG A 91 16. .290 5, .759 44 , .790 1 , .00 46 , .76 N

ATOM 489 N LYS A 92 20. .182 -2. .411 42. .201 1. .00 46. .11 N

ATOM 490 CA LYS A 92 21. .301 -3. .321 42. .470 1. .00 49. .87 C

ATOM 491 C LYS A 92 22. .339 -3. .436 41. .348 1. .00 50. .95 C

ATOM 492 O LYS A 92 22. .207 -2. .812 40. .287 1. .00 45. .10 O

ATOM 493 CB LYS A 92 20. .813 -4. .707 42. .941 1. .00 52. .87 C

ATOM 494 CG LYS A 92 20. .021 -5. .535 41. .947 1. .00 51. .28 C

ATOM 495 CD LYS A 92 19. .243 -6. .608 42. .706 1. .00 55. .20 C

ATOM 496 CE LYS A 92 19. .037 -7. .879 41. .894 1. .00 53. .15 C

ATOM 497 NZ LYS A 92 20. .304 -8. .619 41. .632 1. .00 57. .15 N

ATOM 498 N HIS A 93 23. .392 -4. .206 41. .623 1. .00 49. .81 N

ATOM 499 CA HIS A 93 24. .381 -4. .564 40. .621 1. .00 52. .63 C

ATOM 500 C HIS A 93 23. .806 -5. .684 39. .803 1. .00 56. .19 C

ATOM 501 O HIS A 93 24. .021 -6. .866 40. .092 1. .00 61. .45 O

ATOM 502 CB HIS A 93 25. .707 -4. .963 41. .275 1. .00 54. .23 C

ATOM 503 CG HIS A 93 26. .786 -5. .325 40. .283 1. .00 55. .41 C

ATOM 504 ND1 HIS A 93 27. .498 -4. .398 39. .616 1. .00 57. .14 N

ATOM 505 CD2 HIS A 93 27. .250 -6. .565 39. .845 1. .00 58. .73 C

ATOM 506 CE1 HIS A 93 28. .374 -5. .007 38. .793 1. .00 57. .11 C

ATOM 507 NE2 HIS A 93 28. .227 -6. .332 38. .938 1. .00 59. .68 N

ATOM 508 N TRP A 94 23. .051 -5. .311 38. .777 1. .00 52. .39 N

ATOM 509 CA TRP A 94 22. .260 -6. .251 37. .997 1. .00 48. .14 C

ATOM 510 C TRP A 94 23. .061 -7. .060 37. .029 1. .00 47. .61 C

ATOM 511 O TRP A 94 22. .686 -8. .172 36. .692 1. .00 49. .62 O

ATOM 512 CB TRP A 94 21. .172 -5. .493 37. .235 1. .00 45. .71 C

ATOM 513 CG TRP A 94 19. .974 -5. .164 38. .087 1. .00 41. .77 C

ATOM 514 CD1 TRP A 94 19. .676 -3. .954 38. .698 1. .00 42. .01 C

ATOM 515 CD2 TRP A 94 18. .898 -6. .068 38. .482 1. .00 41. .12 C

ATOM 516 NE1 TRP A 94 18. .512 -4. .040 39. .411 1. .00 40. .58 N

ATOM 517 CE2 TRP A 94 17. .993 -5. .282 39. .327 1. .00 41. .17 C

ATOM 518 CE3 TRP A 94 18. .592 -7. .407 38. .222 1. .00 41. .23 C

ATOM 519 CZ2 TRP A 94 16. .838 -5. .829 39. .881 1. .00 40. .57 C

ATOM 520 CZ3 TRP A 94 17. .428 -7. .944 38. .779 1. .00 40. .24 C

ATOM 521 CH2 TRP A 94 16. .570 -7. .172 39. .586 1. .00 41. .37 c

ATOM 522 N TRP A 95 24. .136 -6. .479 36. .530 1. .00 47. .73 N

ATOM 523 CA TRP A 95 24. .858 -7. .052 35. .429 1. .00 48. .75 C

ATOM 524 C TRP A 95 26. .332 -6. .971 35. .661 1. .00 53. .24 C

ATOM 525 O TRP A 95 26. .816 -6. .022 36. .290 1. .00 54. .41 O

ATOM 526 CB TRP A 95 24. .482 -6. .285 34. .181 1. .00 48. .37 C

ATOM 527 CG TRP A 95 25. .193 -6. .690 32. .925 1. .00 47. .34 c

ATOM 528 CD1 TRP A 95 26. .188 -5. .998 32. .258 1. .00 46. .57 c

ATOM 529 CD2 TRP A 95 24. .955 -7. .881 32. .116 1. .00 46. .43 c

ATOM 530 NE1 TRP A 95 26. .577 -6. .665 31. .135 1. .00 48. .56 N

ATOM 531 CE2 TRP A 95 25. .877 -7. .801 30. .992 1. .00 47. .31 C

ATOM 532 CE3 TRP A 95 24. .110 -8. .962 32. .210 1. .00 45. .20 C

ATOM 533 CZ2 TRP A 95 25. .931 -8. .771 30. .025 1. .00 46. .93 C

ATOM 534 CZ3 TRP A 95 24. .171 -9. .934 31. .226 1. .00 46. .43 c ATOM 535 CH2 TRP A 95 25..061 -9..840 30..161 1..00 47..85 C

ATOM 536 N THR A 96 27. .081 -7. .950 35. .165 1. .00 57. .92 N

ATOM 537 CA THR A 96 28. .531 -7. .918 35. .302 1. .00 59. .83 C

ATOM 538 C THR A 96 29. .247 -8. .175 33. .996 1. .00 59. .87 C

ATOM 539 O THR A 96 28. .836 -9. .013 33. .211 1. .00 57. .79 O

ATOM 540 CB THR A 96 29. .035 -8. .940 36. .317 1. .00 58. .44 C

ATOM 541 OG1 THR A 96 28. .628 -10. .241 35. .895 1. .00 60. .18 O

ATOM 542 CG2 THR A 96 28. .467 -8. .649 37. .673 1. .00 57. .53 C

ATOM 543 N ASP A 97 30. .337 -7. .451 33. .783 1. .00 64. .43 N

ATOM 544 CA ASP A 97 31. .157 -7. .631 32. .576 1. .00 65. .43 C

ATOM 545 C ASP A 97 31. .855 -6. .332 32. .176 1. .00 65. .16 C

ATOM 546 O ASP A 97 33. .051 -6. .325 31. .882 1. .00 67. .16 O

ATOM 547 CB ASP A 97 30. .309 -8. .172 31. .422 1. .00 65. .23 C

ATOM 548 CG ASP A 97 30. .976 -8. .022 30. .083 1. .00 67. .87 c

ATOM 549 OD1 ASP A 97 31. .927 -8. .785 29. .797 1. .00 69. .57 0

ATOM 550 OD2 ASP A 97 30. .531 -7. .144 29. .313 1. .00 66. .77 0

ATOM 551 N LYS A 102 31. .499 -3. .016 25. .734 1. .00 57. .68 N

ATOM 552 CA LYS A 102 30. .340 -2. .350 26. .324 1. .00 57. .04 C

ATOM 553 C LYS A 102 29. .220 -2. .332 25. .291 1. .00 58. .04 C

ATOM 554 O LYS A 102 29. .435 -1. .926 24. .142 1. .00 57. .43 O

ATOM 555 CB LYS A 102 30. .703 -0. .922 26. .751 1. .00 57. .97 c

ATOM 556 CG LYS A 102 30. .104 -0. .461 28. .074 1. .00 53. .61 c

ATOM 557 CD LYS A 102 30. .953 -0. .901 29. .261 1. .00 52. .02 c

ATOM 558 CE LYS A 102 30. .568 -0. .166 30. .537 1. .00 52. .64 c

ATOM 559 NZ LYS A 102 31. .199 -0. .746 31. .760 1. .00 49. .09 N

ATOM 560 N LYS A 103 28. .035 -2. .792 25. .698 1. .00 56. .06 N

ATOM 561 CA LYS A 103 26. .877 -2. .887 24. .802 1. .00 52. .05 C

ATOM 562 C LYS A 103 25. .551 -2. .829 25. .570 1. .00 49. .53 C

ATOM 563 O LYS A 103 25. .526 -3. .005 26. .797 1. .00 49. .84 O

ATOM 564 CB LYS A 103 26. .945 -4. .171 23. .969 1. .00 50. .07 C

ATOM 565 N HIS A 104 24. .458 -2. .581 24. .844 1. .00 43. .77 N

ATOM 566 CA HIS A 104 23. .115 -2. .600 25. .430 1. .00 43. .15 C

ATOM 567 C HIS A 104 22. .742 -3. .985 25. .890 1. .00 41. .83 C

ATOM 568 O HIS A 104 22. .921 -4. .960 25. .166 1. .00 38. .28 O

ATOM 569 CB HIS A 104 22. .065 -2. .100 24. .433 1. .00 41. .20 C

ATOM 570 CG HIS A 104 22. .258 -0. .671 24. .007 1. .00 41. .11 c

ATOM 571 ND1 HIS A 104 21. .924 0 , .367 24 , .791 1 , .00 41 , .35 N

ATOM 572 CD2 HIS A 104 22. .761 -0. .128 22. .829 1. .00 42. .30 C

ATOM 573 CE1 HIS A 104 22. .207 1 , .518 24 , .154 1 , .00 40 , .92 C

ATOM 574 NE2 HIS A 104 22. .713 1 , .215 22 , .951 1 , .00 42 , .34 N

ATOM 575 N VAL A 105 22. .214 -4. .083 27. .102 1. .00 42. .62 N

ATOM 576 CA VAL A 105 21. .738 -5. .358 27. .619 1. .00 40. .89 C

ATOM 577 C VAL A 105 20. .291 -5. .204 28. .027 1. .00 40. .59 C

ATOM 578 O VAL A 105 19. .986 -4. .398 28. .911 1. .00 38. .83 O

ATOM 579 CB VAL A 105 22. .516 -5. .825 28. .870 1. .00 41. .53 C

ATOM 580 CGI VAL A 105 22. .101 -7. .253 29. .226 1. .00 42. .08 C

ATOM 581 CG2 VAL A 105 24. .021 -5. .741 28. .662 1. .00 39. .76 C

ATOM 582 N TRP A 106 19. .410 -5. .982 27. .401 1. .00 38. .49 N

ATOM 583 CA TRP A 106 18. .012 -6. .015 27. .796 1. .00 37. .07 C

ATOM 584 C TRP A 106 17. .848 -6. .616 29. .154 1. .00 38. .87 C

ATOM 585 O TRP A 106 18. .279 -7. .744 29. .394 1. .00 39. .97 O

ATOM 586 CB TRP A 106 17. .186 -6. .765 26. .765 1. .00 37. .22 C

ATOM 587 CG TRP A 106 17. .102 -6. .002 25. .475 1. .00 36. .78 c

ATOM 588 CD1 TRP A 106 17. .690 -6. .319 24. .259 1. .00 37. .30 c

ATOM 589 CD2 TRP A 106 16. .399 -4. .728 25. .240 1. .00 37. .42 c

ATOM 590 NE1 TRP A 106 17. .404 -5. .368 23. .308 1. .00 39. .60 N

ATOM 591 CE2 TRP A 106 16. .633 -4. .385 23. .827 1. .00 38. .39 C

ATOM 592 CE3 TRP A 106 15. .623 -3. .875 26. .024 1. .00 37. .14 C

ATOM 593 CZ2 TRP A 106 16. .113 -3. .232 23. .252 1. .00 37. .43 C

ATOM 594 CZ3 TRP A 106 15. .106 -2. .707 25. .431 1. .00 36. .48 c

ATOM 595 CH2 TRP A 106 15. .350 -2. .395 24. .082 1. .00 35. .95 c ATOM 596 N PHE A 107 17..245 -5..852 30..062 1..00 36..56 N

ATOM 597 CA PHE A 107 16. .987 -6. .293 31. .433 1. .00 38. .97 C

ATOM 598 C PHE A 107 16. .149 -7. .565 31. .468 1. .00 42. .42 C

ATOM 599 O PHE A 107 16. .505 -8. .529 32. .155 1. .00 44. .36 O

ATOM 600 CB PHE A 107 16. .275 -5. .188 32. .222 1. .00 37. .11 C

ATOM 601 CG PHE A 107 15. .782 -5. .614 33. .587 1. .00 36. .44 c

ATOM 602 CD1 PHE A 107 16. .649 -5. .657 34. .672 1. .00 33. .82 c

ATOM 603 CD2 PHE A 107 14. .441 -5. .935 33. .792 1. .00 34. .62 c

ATOM 604 CE1 PHE A 107 16. .200 -6. .026 35. .930 1. .00 34. .47 c

ATOM 605 CE2 PHE A 107 13. .982 -6. .300 35. .052 1. .00 34. .81 c

ATOM 606 CZ PHE A 107 14. .864 -6. .348 36. .123 1. .00 35. .97 c

ATOM 607 N GLY A 108 15. .045 -7. .551 30. .721 1. .00 42. .34 N

ATOM 608 CA GLY A 108 14. .105 -8. .661 30. .670 1. .00 44. .36 C

ATOM 609 C GLY A 108 14. .581 -9. .871 29. .884 1. .00 47. .92 c

ATOM 610 O GLY A 108 14. .391 -10. .994 30. .332 1. .00 50. .45 0

ATOM 611 N GLU A 109 15. .195 -9. .650 28. .721 1. .00 46. .57 N

ATOM 612 CA GLU A 109 15. .662 -10. .746 27. .866 1. .00 47. .85 C

ATOM 613 C GLU A 109 16. .954 -11. .435 28. .321 1. .00 49. .42 C

ATOM 614 O GLU A 109 17. .218 -12. .561 27. .911 1. .00 52. .89 O

ATOM 615 CB GLU A 109 15. .861 -10. .268 26. .422 1. .00 49. .00 c

ATOM 616 CG GLU A 109 14. .585 -9. .937 25. .655 1. .00 52. .06 c

ATOM 617 CD GLU A 109 14. .847 -9. .501 24. .217 1. .00 55. .17 c

ATOM 618 OE1 GLU A 109 15. .955 -9. .764 23. .698 1. .00 56. .09 0

ATOM 619 OE2 GLU A 109 13. .948 -8. .889 23. .596 1. .00 55. .20 0

ATOM 620 N SER A 110 17. .761 -10. .779 29. .150 1. .00 46. .39 N

ATOM 621 CA SER A 110 19. .156 -11. .207 29. .321 1. .00 44. .06 C

ATOM 622 C SER A 110 19. .780 -11. .154 30. .703 1. .00 41. .95 C

ATOM 623 O SER A 110 20. .888 -11. .638 30. .874 1. .00 47. .65 0

ATOM 624 CB SER A 110 20. .056 -10. .417 28. .377 1. .00 42. .08 c

ATOM 625 OG SER A 110 19. .645 -10. .606 27. .040 1. .00 46. .62 0

HETATM 626 N MSE A 111 19. .106 -10. .563 31. .678 1. .00 41. .02 N

HETATM 627 CA MSE A 111 19. .715 -10. .388 32. .998 1. .00 43. .38 C

HETATM 628 C MSE A 111 19. .124 -11. .332 34. .015 1. .00 44. .81 C

HETATM 629 O MSE A 111 17. .967 -11. .764 33. .901 1. .00 41. .03 O

HETATM 630 CB MSE A 111 19. .648 -8. .923 33. .461 1. .00 45. .45 c

HETATM 631 CG MSE A 111 20. .287 -7. .965 32. .440 1. .00 48. .54 c

HETATM 632 SE MSE A 111 20. .515 -6. .094 33. .074 1. .00 52. .76 SE

HETATM 633 CE MSE A 111 19. .863 -6. .298 34. .907 1. .00 52. .06 C

ATOM 634 N ASP A 112 19. .926 -11. .647 35. .029 1. .00 45. .66 N

ATOM 635 CA ASP A 112 19. .551 -12. .608 36. .049 1. .00 47. .58 C

ATOM 636 C ASP A 112 18. .533 -12. .018 36. .998 1. .00 48. .08 C

ATOM 637 O ASP A 112 18. .827 -11. .077 37. .754 1. .00 50. .01 O

ATOM 638 CB ASP A 112 20. .786 -13. .114 36. .803 1. .00 51. .19 C

ATOM 639 CG ASP A 112 21. .606 -14. .095 35. .979 1. .00 56. .29 c

ATOM 640 OD1 ASP A 112 21. .013 -15. .057 35. .425 1. .00 55. .99 0

ATOM 641 OD2 ASP A 112 22. .841 -13. .901 35. .884 1. .00 60. .60 0

ATOM 642 N GLY A 113 17. .330 -12. .581 36. .954 1. .00 45. .14 N

ATOM 643 CA GLY A 113 16. .202 -12. .023 37. .690 1. .00 44. .01 C

ATOM 644 C GLY A 113 15. .470 -11. .025 36. .819 1. .00 41. .80 C

ATOM 645 O GLY A 113 14. .514 -10. .398 37. .261 1. .00 41. .12 O

ATOM 646 N GLY A 114 15. .925 -10. .895 35. .573 1. .00 42. .25 N

ATOM 647 CA GLY A 114 15. .304 -10. .004 34. .601 1. .00 42. .30 C

ATOM 648 C GLY A 114 13. .860 -10. .388 34. .353 1. .00 43. .34 C

ATOM 649 O GLY A 114 13. .487 -11. .546 34. .530 1. .00 44. .59 O

ATOM 650 N PHE A 115 13. .049 -9. .405 33. .970 1. .00 40. .37 N

ATOM 651 CA PHE A 115 11. .655 -9. .628 33. .611 1. .00 37. .61 C

ATOM 652 C PHE A 115 11. .138 -8. .482 32. .751 1. .00 37. .99 C

ATOM 653 O PHE A 115 11. .581 -7. .331 32. .881 1. .00 34. .00 O

ATOM 654 CB PHE A 115 10. .767 -9. .793 34. .860 1. .00 38. .01 C

ATOM 655 CG PHE A 115 10. .804 -8. .624 35. .806 1. .00 36. .99 c

ATOM 656 CD1 PHE A 115 9. .898 -7. .571 35. .672 1. .00 38. .18 c ATOM 657 CD2 PHE A 115 11..725 -8..584 36..855 1..00 37..90 C

ATOM 658 CE1 PHE A 115 9. .926 -6. .489 36. .548 1. .00 37. .15 C

ATOM 659 CE2 PHE A 115 11. .754 -7. .507 37. .740 1. .00 37. .36 C

ATOM 660 CZ PHE A 115 10. .858 -6. .456 37. .581 1. .00 36. .51 C

ATOM 661 N GLN A 116 10. .195 -8. .801 31. .877 1. .00 36. .05 N

ATOM 662 CA GLN A 116 9. .528 -7. .783 31. .110 1. .00 36. .62 C

ATOM 663 C GLN A 116 8. .381 -7. .184 31. .918 1. .00 36. .44 C

ATOM 664 O GLN A 116 7. .861 -7. .805 32. .870 1. .00 34. .62 O

ATOM 665 CB GLN A 116 9. .078 -8. .336 29. .765 1. .00 39. .27 C

ATOM 666 CG GLN A 116 10. .261 -8. .562 28. .836 1. .00 43. .09 c

ATOM 667 CD GLN A 116 9. .847 -8. .922 27. .426 1. .00 45. .59 c

ATOM 668 OE1 GLN A 116 9. .045 -9. .832 27. .216 1. .00 49. .50 0

ATOM 669 NE2 GLN A 116 10. .404 -8. .217 26. .448 1. .00 47. .51 N

ATOM 670 N PHE A 117 8. .013 -5. .960 31. .559 1. .00 32. .56 N

ATOM 671 CA PHE A 117 7. .015 -5. .250 32. .311 1. .00 31. .12 C

ATOM 672 C PHE A 117 5. .643 -5. .633 31. .795 1. .00 29. .95 C

ATOM 673 O PHE A 117 5. .422 -5. .713 30. .592 1. .00 29. .59 O

ATOM 674 CB PHE A 117 7. .231 -3. .731 32. .203 1. .00 32. .19 C

ATOM 675 CG PHE A 117 8. .646 -3. .296 32. .446 1. .00 31. .56 C

ATOM 676 CD1 PHE A 117 9. .353 -3. .753 33. .558 1. .00 31. .15 C

ATOM 677 CD2 PHE A 117 9. .271 -2. .415 31. .566 1. .00 31. .73 C

ATOM 678 CE1 PHE A 117 10. .667 -3. .359 33. .770 1. .00 33. .22 c

ATOM 679 CE2 PHE A 117 10. .582 -2. .002 31. .780 1. .00 31. .51 c

ATOM 680 CZ PHE A 117 11. .283 -2. .477 32. .880 1. .00 32. .68 c

ATOM 681 N SER A 118 4. .713 -5. .878 32. .701 1. .00 28. .79 N

ATOM 682 CA SER A 118 3. .349 -6. .073 32. .264 1. .00 29. .40 C

ATOM 683 C SER A 118 2. .371 -5. .153 33. .008 1. .00 27. .73 C

ATOM 684 O SER A 118 2. .743 -4. .440 33. .950 1. .00 26. .27 0

ATOM 685 CB SER A 118 2. .936 -7. .553 32. .321 1. .00 31. .27 c

ATOM 686 OG SER A 118 2. .990 -8. .010 33. .646 1. .00 35. .46 0

ATOM 687 N TYR A 119 1. .125 -5. .166 32. .553 1. .00 25. .74 N

ATOM 688 CA TYR A 119 0. .165 -4. .165 32. .935 1. .00 26. .41 C

ATOM 689 C TYR A 119 -1. .212 -4. .788 33. .168 1. .00 26. .50 C

ATOM 690 O TYR A 119 -1. .609 -5. .708 32. .457 1. .00 28. .51 O

ATOM 691 CB TYR A 119 0. .137 -3. .079 31. .853 1. .00 24. .47 c

ATOM 692 CG TYR A 119 1. .508 -2. .434 31. .636 1. .00 23. .24 c

ATOM 693 CD1 TYR A 119 2. .488 -3. .058 30. .870 1. .00 22. .87 c

ATOM 694 CD2 TYR A 119 1. .825 -1. .210 32. .223 1. .00 23. .40 c

ATOM 695 CE1 TYR A 119 3. .744 -2. .490 30. .700 1. .00 22. .31 c

ATOM 696 CE2 TYR A 119 3. .075 -0. .631 32. .055 1. .00 22. .27 c

ATOM 697 CZ TYR A 119 4. .027 -1. .271 31. .288 1. .00 21. .85 c

ATOM 698 OH TYR A 119 5. .267 -0. .698 31. .131 1. .00 20. .56 0

ATOM 699 N GLY A 120 -1. .912 -4. .300 34. .188 1. .00 26. .06 N

ATOM 700 CA GLY A 120 -3. .288 -4. .690 34. .454 1. .00 28. .22 c

ATOM 701 C GLY A 120 -3. .421 -5. .628 35. .638 1. .00 29. .03 c

ATOM 702 O GLY A 120 -2. .466 -6. .341 35. .981 1. .00 29. .53 0

ATOM 703 N ASN A 121 -4. .607 -5. .629 36. .246 1. .00 29. .00 N

ATOM 704 CA ASN A 121 -4. .939 -6. .515 37. .374 1. .00 31. .07 C

ATOM 705 C ASN A 121 -4. .333 -7. .906 37. .213 1. .00 31. .94 C

ATOM 706 O ASN A 121 -4. .709 -8. .628 36. .296 1. .00 30. .98 O

ATOM 707 CB ASN A 121 -6. .459 -6. .682 37. .481 1. .00 30. .94 c

ATOM 708 CG ASN A 121 -7. .190 -5. .370 37. .626 1. .00 31. .09 c

ATOM 709 OD1 ASN A 121 -6. .977 -4. .425 36. .853 1. .00 30. .67 0

ATOM 710 ND2 ASN A 121 -8. .081 -5. .305 38. .621 1. .00 30. .99 N

ATOM 711 N PRO A 122 -3. .384 -8. .274 38. .089 1. .00 33. .93 N

ATOM 712 CA PRO A 122 -2. .708 -9. .590 38. .030 1. .00 34. .44 C

ATOM 713 C PRO A 122 -3. .631 -10. .822 38. .223 1. .00 33. .30 C

ATOM 714 O PRO A 122 -3. .264 -11. .925 37. .824 1. .00 32. .98 O

ATOM 715 CB PRO A 122 -1. .684 -9. .517 39. .181 1. .00 35. .43 C

ATOM 716 CG PRO A 122 -1. .536 -8. .051 39. .470 1. .00 36. .66 C

ATOM 717 CD PRO A 122 -2. .880 -7. .444 39. .197 1. .00 33. .61 C ATOM 718 N GLU A 123 -4..802 -10..646 38..825 1..00 32..12 N

ATOM 719 CA GLU A 123 -5. .731 -11. .767 38. .992 1. .00 34. .40 C

ATOM 720 C GLU A 123 -6. .412 -12. .179 37. .666 1. .00 35. .12 C

ATOM 721 O GLU A 123 -7. .013 -13. .250 37. .583 1. .00 36. .24 O

ATOM 722 CB GLU A 123 -6. .776 -11. .470 40. .088 1. .00 34. .38 C

ATOM 723 CG GLU A 123 -7. .849 -10. .443 39. .707 1. .00 36. .49 C

ATOM 724 CD GLU A 123 -7. .394 -8. .982 39. .836 1. .00 36. .31 C

ATOM 725 OE1 GLU A 123 -6. .170 -8. .705 39. .806 1. .00 35. .77 O

ATOM 726 OE2 GLU A 123 -8. .274 -8. .099 39. .948 1. .00 35. .10 O

ATOM 727 N LEU A 124 -6. .305 -11. .338 36. .635 1. .00 32. .95 N

ATOM 728 CA LEU A 124 -6. .909 -11. .641 35. .338 1. .00 32. .21 C

ATOM 729 C LEU A 124 -5. .941 -12. .415 34. .456 1. .00 30. .73 C

ATOM 730 O LEU A 124 -4. .736 -12. .169 34. .503 1. .00 32. .05 O

ATOM 731 CB LEU A 124 -7. .361 -10. .359 34. .636 1. .00 31. .92 C

ATOM 732 CG LEU A 124 -8. .501 -9. .595 35. .314 1. .00 33. .52 c

ATOM 733 CD1 LEU A 124 -8. .620 -8. .192 34. .733 1. .00 33. .28 c

ATOM 734 CD2 LEU A 124 -9. .826 -10. .333 35. .187 1. .00 32. .95 c

ATOM 735 N PRO A 125 -6. .455 -13. .368 33. .655 1. .00 30. .68 N

ATOM 736 CA PRO A 125 -5. .592 -14. .141 32. .746 1. .00 29. .53 C

ATOM 737 C PRO A 125 -4. .914 -13. .228 31. .738 1. .00 30. .75 C

ATOM 738 O PRO A 125 -5. .457 -12. .167 31. .383 1. .00 30. .68 O

ATOM 739 CB PRO A 125 -6. .572 -15. .032 31. .991 1. .00 29. .99 c

ATOM 740 CG PRO A 125 -7. .807 -15. .078 32. .840 1. .00 31. .45 c

ATOM 741 CD PRO A 125 -7. .872 -13. .761 33. .550 1. .00 29. .44 c

ATOM 742 N GLU A 126 -3. .755 -13. .652 31. .256 1. .00 30. .38 N

ATOM 743 CA GLU A 126 -2. .942 -12. .822 30. .410 1. .00 31. .49 C

ATOM 744 C GLU A 126 -3. .600 -12. .507 29. .042 1. .00 30. .34 C

ATOM 745 O GLU A 126 -3. .395 -11. .421 28. .505 1. .00 29. .61 O

ATOM 746 CB GLU A 126 -1. .574 -13. .467 30. .220 1. .00 36. .58 c

ATOM 747 CG GLU A 126 -0. .507 -12. .485 29. .746 1. .00 43. .71 c

ATOM 748 CD GLU A 126 0. .574 -13. .151 28. .920 1. .00 49. .76 c

ATOM 749 OE1 GLU A 126 1. .154 -14. .156 29. .393 1. .00 51. .92 0

ATOM 750 OE2 GLU A 126 0. .839 -12. .669 27. .796 1. .00 54. .75 0

ATOM 751 N ASP A 127 -4. .370 -13. .443 28. .481 1. .00 26. .43 N

ATOM 752 CA ASP A 127 -5. .005 -13. .199 27. .178 1. .00 26. .44 C

ATOM 753 C ASP A 127 -6. .032 -12. .079 27. .292 1. .00 23. .99 C

ATOM 754 O ASP A 127 -6. .156 -11. .249 26. .401 1. .00 23. .64 0

ATOM 755 CB ASP A 127 -5. .669 -14. .459 26. .618 1. .00 27. .61 c

ATOM 756 CG ASP A 127 -6. .717 -15. .043 27. .558 1. .00 29. .89 c

ATOM 757 OD1 ASP A 127 -6. .301 -15. .686 28. .550 1. .00 31. .64 0

ATOM 758 OD2 ASP A 127 -7. .942 -14. .859 27. .319 1. .00 28. .86 0

ATOM 759 N VAL A 128 -6. .728 -12. .059 28. .425 1. .00 22. .59 N

ATOM 760 CA VAL A 128 -7. .767 -11. .082 28. .731 1. .00 22. .34 C

ATOM 761 C VAL A 128 -7. .159 -9. .679 28. .883 1. .00 22. .43 C

ATOM 762 O VAL A 128 -7. .724 -8. .693 28. .384 1. .00 21. .91 0

ATOM 763 CB VAL A 128 -8. .549 -11. .534 29. .988 1. .00 22. .29 c

ATOM 764 CGI VAL A 128 -9. .332 -10. .401 30. .635 1. .00 22. .10 c

ATOM 765 CG2 VAL A 128 -9. .464 -12. .693 29. .636 1. .00 22. .92 c

ATOM 766 N LEU A 129 -6. .004 -9. .599 29. .554 1. .00 22. .47 N

ATOM 767 CA LEU A 129 -5. .280 -8. .338 29. .697 1. .00 23. .61 C

ATOM 768 C LEU A 129 -4. .766 -7. .838 28. .351 1. .00 24. .39 C

ATOM 769 O LEU A 129 -4. .842 -6. .637 28. .069 1. .00 24. .63 0

ATOM 770 CB LEU A 129 -4. .111 -8. .461 30. .686 1. .00 22. .76 c

ATOM 771 CG LEU A 129 -4. .509 -8. .657 32. .154 1. .00 23. .54 c

ATOM 772 CD1 LEU A 129 -3. .257 -8. .794 33. .018 1. .00 23. .56 c

ATOM 773 CD2 LEU A 129 -5. .388 -7. .515 32. .641 1. .00 22. .87 c

ATOM 774 N ASP A 130 -4. .221 -8. .752 27. .542 1. .00 23. .79 N

ATOM 775 CA ASP A 130 -3. .799 -8. .421 26. .183 1. .00 24. .69 C

ATOM 776 C ASP A 130 -4. .921 -7. .736 25. .439 1. .00 22. .49 C

ATOM 777 O ASP A 130 -4. .688 -6. .737 24. .788 1. .00 21. .61 0

ATOM 778 CB ASP A 130 -3. .383 -9. .672 25. .395 1. .00 28. .37 c ATOM 779 CG ASP A 130 -2..019 -10..182 25..799 1..00 32..80 C

ATOM 780 OD1 ASP A 130 -1. .283 -9. .423 26. .458 1. .00 36. .79 O

ATOM 781 OD2 ASP A 130 -1. .675 -11. .338 25. .456 1. .00 37. .63 O

ATOM 782 N VAL A 131 -6. .128 -8. .298 25. .536 1. .00 20. .25 N

ATOM 783 CA VAL A 131 -7. .292 -7. .742 24. .855 1. .00 19. .02 C

ATOM 784 C VAL A 131 -7. .683 -6. .365 25. .412 1. .00 19. .07 C

ATOM 785 O VAL A 131 -7. .991 -5. .450 24. .651 1. .00 18. .68 O

ATOM 786 CB VAL A 131 -8. .491 -8. .710 24. .882 1. .00 17. .90 C

ATOM 787 CGI VAL A 131 -9. .738 -8. .032 24. .341 1. .00 17. .99 c

ATOM 788 CG2 VAL A 131 -8. .173 -9. .954 24. .066 1. .00 18. .11 c

ATOM 789 N GLN A 132 -7. .657 -6. .202 26. .729 1. .00 19. .10 N

ATOM 790 CA GLN A 132 -8. .042 -4. .908 27. .279 1. .00 20. .70 C

ATOM 791 C GLN A 132 -7. .042 -3. .855 26. .806 1. .00 21. .65 C

ATOM 792 O GLN A 132 -7. .445 -2. .782 26. .362 1. .00 21. .30 O

ATOM 793 CB GLN A 132 -8. .185 -4. .944 28. .805 1. .00 20. .72 c

ATOM 794 CG GLN A 132 -9. .378 -5. .781 29. .276 1. .00 21. .19 c

ATOM 795 CD GLN A 132 -10. .726 -5. .081 29. .127 1. .00 21. .92 c

ATOM 796 OE1 GLN A 132 -10. .990 -4. .415 28. .126 1. .00 21. .98 0

ATOM 797 NE2 GLN A 132 -11. .598 -5. .238 30. .135 1. .00 22. .19 N

ATOM 798 N LEU A 133 -5. .748 -4. .184 26. .847 1. .00 21. .57 N

ATOM 799 CA LEU A 133 -4. .714 -3. .271 26. .341 1. .00 21. .58 C

ATOM 800 C LEU A 133 -4. .851 -3. .030 24. .855 1. .00 20. .69 C

ATOM 801 O LEU A 133 -4. .658 -1. .912 24. .395 1. .00 21. .19 O

ATOM 802 CB LEU A 133 -3. .294 -3. .788 26. .645 1. .00 22. .35 C

ATOM 803 CG LEU A 133 -2. .638 -3. .356 27. .953 1. .00 22. .64 C

ATOM 804 CD1 LEU A 133 -2. .252 -1. .884 27. .886 1. .00 22. .83 C

ATOM 805 CD2 LEU A 133 -3. .580 -3. .596 29. .122 1. .00 22. .05 C

ATOM 806 N ALA A 134 -5. .187 -4. .067 24. .096 1. .00 20. .31 N

ATOM 807 CA ALA A 134 -5. .292 -3. .915 22. .643 1. .00 19. .59 C

ATOM 808 C ALA A 134 -6. .370 -2. .893 22. .293 1. .00 19. .22 C

ATOM 809 O ALA A 134 -6. .172 -2. .050 21. .412 1. .00 20. .01 O

ATOM 810 CB ALA A 134 -5. .571 -5. .253 21. .978 1. .00 19. .84 C

ATOM 811 N PHE A 135 -7. .487 -2. .936 23. .015 1. .00 18. .53 N

ATOM 812 CA PHE A 135 -8. .571 -1. .973 22. .810 1. .00 19. .13 C

ATOM 813 C PHE A 135 -8. .073 -0. .541 23. .023 1. .00 19. .37 C

ATOM 814 O PHE A 135 -8. .390 0 , .351 22 , .246 1 , .00 20 , .12 O

ATOM 815 CB PHE A 135 -9. .798 -2. .293 23. .706 1. .00 17. .99 C

ATOM 816 CG PHE A 135 -10. .850 -3. .153 23. .020 1. .00 17. .81 c

ATOM 817 CD1 PHE A 135 -10. .744 -4. .555 23. .030 1. .00 17. .36 c

ATOM 818 CD2 PHE A 135 -11. .919 -2. .567 22. .331 1. .00 16. .98 c

ATOM 819 CE1 PHE A 135 -11. .688 -5. .356 22. .390 1. .00 16. .74 c

ATOM 820 CE2 PHE A 135 -12. .860 -3. .364 21. .677 1. .00 16. .75 c

ATOM 821 CZ PHE A 135 -12. .754 -4. .759 21. .720 1. .00 17. .00 c

ATOM 822 N LEU A 136 -7. .284 -0. .334 24. .067 1. .00 19. .65 N

ATOM 823 CA LEU A 136 -6. .753 0 , .986 24 , .358 1. .00 20. .78 C

ATOM 824 C LEU A 136 -5. .689 1 , .387 23, .358 1 , .00 20 , .87 c

ATOM 825 O LEU A 136 -5. .698 2 , .490 22 , .889 1 , .00 22 , .95 0

ATOM 826 CB LEU A 136 -6. .186 1 , .033 25, .771 1 , .00 20 , .88 c

ATOM 827 CG LEU A 136 -7. .235 0 , .940 26, .871 1 , .00 21 , .03 c

ATOM 828 CD1 LEU A 136 -6. .569 0 , .547 28 , .177 1 , .00 21 , .26 c

ATOM 829 CD2 LEU A 136 -7. .997 2 , .247 27 , .012 1 , .00 21 , .23 c

ATOM 830 N ARG A 137 -4. .788 0 , .469 23, .029 1 , .00 21 , .46 N

ATOM 831 CA ARG A 137 -3. .692 0 , .714 22 , .094 1 , .00 20 , .77 C

ATOM 832 C ARG A 137 -4. .183 0 , .985 20 , .663 1 , .00 22 , .79 C

ATOM 833 O ARG A 137 -3. .684 1 , .881 19, .991 1 , .00 23, .53 0

ATOM 834 CB ARG A 137 -2. .724 -0. .481 22. .098 1. .00 18. .68 c

ATOM 835 CG ARG A 137 -1. .948 -0. .677 23. .406 1. .00 18. .15 c

ATOM 836 CD ARG A 137 -1. .271 -2. .064 23. .498 1. .00 17. .84 c

ATOM 837 NE ARG A 137 -0. .304 -2. .220 22. .420 1. .00 17. .99 N

ATOM 838 CZ ARG A 137 -0. .391 -3. .145 21. .469 1. .00 18. .39 C

ATOM 839 NH1 ARG A 137 -1. .359 -4. .048 21. .510 1. .00 19. .12 N ATOM 840 NH2 ARG A 137 0..503 -3., 182 20.,494 1., 00 17., 55 N

ATOM 841 N LEU A 138 -5. .159 0. .211 20. .205 1. .00 22. .57 N

ATOM 842 CA LEU A 138 -5. .679 0. .383 18. .862 1. .00 24. .01 C

ATOM 843 C LEU A 138 -6. .520 1. .664 18. .720 1. .00 23. .72 C

ATOM 844 O LEU A 138 -6. .466 2. .326 17. .685 1. .00 21. .93 O

ATOM 845 CB LEU A 138 -6. .513 -0. , 849 18. , 435 1. , 00 25. , 93 C

ATOM 846 CG LEU A 138 -6. .900 -0. , 883 16. , 947 1. , 00 29. , 54 C

ATOM 847 CD1 LEU A 138 -5. .635 -1. , 028 16. , 087 1. , 00 29. , 72 C

ATOM 848 CD2 LEU A 138 -7. .915 -1. , 984 16. , 630 1. , 00 28. , 25 C

ATOM 849 N LEU A 139 -7. .276 2. .015 19. .759 1. .00 23. .29 N

ATOM 850 CA LEU A 139 -8. .405 2. .939 19. .580 1. .00 23. .89 C

ATOM 851 C LEU A 139 -8. .353 4. .239 20. .415 1. .00 24. .63 C

ATOM 852 O LEU A 139 -9. .356 4. .972 20. .489 1. .00 25. .50 O

ATOM 853 CB LEU A 139 -9. .732 2. .168 19. .800 1. .00 22. .64 C

ATOM 854 CG LEU A 139 -9. .960 1. .000 18. .827 1. .00 21. .78 C

ATOM 855 CD1 LEU A 139 -10. .857 -0. ,069 19. , 441 1. , 00 22. , 25 c

ATOM 856 CD2 LEU A 139 -10. .513 1. .485 17. .486 1. .00 20. .90 c

ATOM 857 N SER A 140 -7. .201 4. .522 21. .033 1. .00 23. .63 N

ATOM 858 CA SER A 140 -6. .989 5. .806 21. .735 1. .00 23. .35 C

ATOM 859 C SER A 140 -6. .490 6. .849 20. .729 1. .00 23. .62 C

ATOM 860 O SER A 140 -5. .945 6. .482 19. .695 1. .00 23. .12 O

ATOM 861 CB SER A 140 -5. .968 5. .629 22. .859 1. .00 23. .00 c

ATOM 862 OG SER A 140 -6. .499 4. .817 23. .908 1. .00 21. .55 0

ATOM 863 N SER A 141 -6. .662 8. , 139 21. , 000 1. , 00 23. , 44 N

ATOM 864 CA SER A 141 -6. .038 9. .139 20. .122 1. .00 24. .09 C

ATOM 865 C SER A 141 -4. .544 9. .204 20. .320 1. .00 24. .32 C

ATOM 866 O SER A 141 -3. .833 9. .517 19. .380 1. , 00 25. , 00 O

ATOM 867 CB SER A 141 -6. .633 10. .537 20. .307 1. .00 25. .11 c

ATOM 868 OG SER A 141 -6. .812 10. .831 21. .671 1. .00 27. .44 0

ATOM 869 N ARG A 142 -4. .086 8. .972 21. .533 1. .00 23. .71 N

ATOM 870 CA ARG A 142 -2. .677 9. .060 21. .886 1. .00 25. .07 C

ATOM 871 C ARG A 142 -2. .320 8. .334 23. .184 1. .00 22. .11 C

ATOM 872 O ARG A 142 -3. .180 7. .886 23. .891 1. .00 20. .95 O

ATOM 873 CB ARG A 142 -2. .176 10. .502 21. .873 1. .00 29. .70 c

ATOM 874 CG ARG A 142 -2. .790 11. .409 22. .905 1. .00 38. .67 c

ATOM 875 CD ARG A 142 -2. .895 12. .845 22. .418 1. .00 46. .81 c

ATOM 876 NE ARG A 142 -3. .840 13. .009 21. .304 1. .00 51. .33 N

ATOM 877 CZ ARG A 142 -4. .663 14. .041 21. .152 1. .00 50. .93 C

ATOM 878 NH1 ARG A 142 -4. .668 15. .025 22. .024 1. .00 49. .94 N

ATOM 879 NH2 ARG A 142 -5. .472 14. .102 20. .123 1. .00 54. .85 N

ATOM 880 N ALA A 143 -1. .039 8. .183 23. .452 1. .00 20. .94 N

ATOM 881 CA ALA A 143 -0. .554 7. .499 24. .660 1. .00 20. .33 C

ATOM 882 C ALA A 143 0. .810 8. .036 25. .078 1. .00 19. .35 C

ATOM 883 O ALA A 143 1. .555 8. .590 24. .260 1. .00 18. .49 O

ATOM 884 CB ALA A 143 -0. .475 5. .994 24. .442 1. .00 19. .72 C

ATOM 885 N SER A 144 1. .148 7. .853 26. .346 1. .00 18. .41 N

ATOM 886 CA SER A 144 2. .450 8. .271 26. .825 1. .00 18. .96 C

ATOM 887 C SER A 144 2. .822 7. .418 27. .999 1. .00 18. .29 C

ATOM 888 O SER A 144 1. .963 6. .842 28. .671 1. .00 17. .74 O

ATOM 889 CB SER A 144 2. .456 9. .751 27. .248 1. .00 19. .51 C

ATOM 890 OG SER A 144 1. .548 9. .937 28. .328 1. .00 21. .42 0

ATOM 891 N GLN A 145 4. .118 7. , 362 28. , 252 1. , 00 17. , 97 N

ATOM 892 CA GLN A 145 4. .632 6. .654 29. .395 1. .00 18. .49 C

ATOM 893 C GLN A 145 5. .948 7. .224 29. .784 1. .00 18. .48 C

ATOM 894 O GLN A 145 6. .771 7. .562 28. .908 1. .00 18. .06 O

ATOM 895 CB GLN A 145 4. .827 5. .175 29. .090 1. .00 17. .53 C

ATOM 896 CG GLN A 145 4. .934 4. .354 30. .354 1. .00 17. .25 c

ATOM 897 CD GLN A 145 4. .982 2. .868 30. .050 1. .00 17. .52 c

ATOM 898 OE1 GLN A 145 4. .811 2. .445 28. .891 1. .00 15. .75 0

ATOM 899 NE2 GLN A 145 5. .225 2. .070 31. .086 1. .00 16. .64 N

ATOM 900 N GLN A 146 6. .138 7. .332 31. .095 1. .00 19. .19 N ATOM 901 CA GLN A 146 7..436 7..719 31..653 1..00 22..04 C

ATOM 902 C GLN A 146 8. .124 6. .547 32. .298 1. .00 21. .36 C

ATOM 903 O GLN A 146 7. .472 5. ,715 32. , 909 1. , 00 20. ,81 O

ATOM 904 CB GLN A 146 7. .271 8. .806 32. .696 1. .00 22. .05 C

ATOM 905 CG GLN A 146 7. .100 10. .169 32. .086 1. .00 24. .38 C

ATOM 906 CD GLN A 146 6. .779 11. .201 33. .138 1. , 00 26. ,21 C

ATOM 907 OE1 GLN A 146 7. .318 11. .167 34. .259 1. .00 26. .11 O

ATOM 908 NE2 GLN A 146 5. .890 12. .111 32. .794 1. .00 25. .62 N

ATOM 909 N ILE A 147 9. .444 6. .511 32. .159 1. .00 22. .65 N

ATOM 910 CA ILE A 147 10. .304 5. .573 32. .885 1. .00 23. .42 C

ATOM 911 C ILE A 147 11. .370 6. .378 33. .593 1. .00 23. .30 C

ATOM 912 O ILE A 147 11. .938 7. .294 33. .002 1. .00 24. .07 O

ATOM 913 CB ILE A 147 11. .021 4. .606 31. .914 1. .00 24. .82 C

ATOM 914 CGI ILE A 147 10. .014 3. .908 31. .017 1. .00 26. .38 C

ATOM 915 CG2 ILE A 147 11. .828 3. .559 32. .682 1. .00 25. .46 C

ATOM 916 CD1 ILE A 147 9. .105 2. .922 31. .730 1. .00 26. .73 C

ATOM 917 N THR A 148 11. .654 6. .032 34. .846 1. .00 23. .35 N

ATOM 918 CA THR A 148 12. .739 6. , 656 35. , 606 1. , 00 23. ,81 C

ATOM 919 C THR A 148 13. .844 5. .609 35. .797 1. .00 24. .79 C

ATOM 920 O THR A 148 13. .586 4. .511 36. .276 1. .00 23. .95 O

ATOM 921 CB THR A 148 12. .254 7. .161 36. .988 1. , 00 23. ,86 C

ATOM 922 OG1 THR A 148 11. .226 8. .131 36. .808 1. .00 24. .14 0

ATOM 923 CG2 THR A 148 13. .381 7. .800 37. .782 1. .00 23. .21 c

ATOM 924 N TYR A 149 15. .056 5. .951 35. .377 1. .00 25. .48 N

ATOM 925 CA TYR A 149 16. .236 5. .125 35. .587 1. .00 27. .15 C

ATOM 926 C TYR A 149 17. .012 5. .709 36. .770 1. .00 28. .14 C

ATOM 927 O TYR A 149 17. .486 6. .856 36. .714 1. .00 28. .21 O

ATOM 928 CB TYR A 149 17. .074 5. .153 34. .317 1. .00 28. .66 c

ATOM 929 CG TYR A 149 18. .351 4. .343 34. .314 1. .00 29. .04 c

ATOM 930 CD1 TYR A 149 18. .331 2. .976 34. .031 1. .00 30. .91 c

ATOM 931 CD2 TYR A 149 19. .586 4. .950 34. .544 1. .00 29. .44 c

ATOM 932 CE1 TYR A 149 19. .505 2. .228 33. .994 1. .00 30. .68 c

ATOM 933 CE2 TYR A 149 20. .766 4. .218 34. .507 1. .00 30. .06 c

ATOM 934 CZ TYR A 149 20. .716 2. .855 34. .236 1. .00 31. .27 c

ATOM 935 OH TYR A 149 21. .869 2. .117 34. .197 1. .00 31. .86 0

ATOM 936 N HIS A 150 17. .102 4. .945 37. .856 1. .00 28. .38 N

ATOM 937 CA HIS A 150 17. .922 5. .339 39. .015 1. .00 28. .83 c

ATOM 938 C HIS A 150 19. .320 4. .838 38. .787 1. .00 29. .09 c

ATOM 939 O HIS A 150 19. .514 3. .684 38. .433 1. .00 29. .52 0

ATOM 940 CB HIS A 150 17. .362 4. .778 40. .314 1. .00 27. .57 c

ATOM 941 CG HIS A 150 16. .014 5. .335 40. .694 1. .00 28. .00 c

ATOM 942 ND1 HIS A 150 15. .870 6. .485 41. .404 1. .00 29. .61 N

ATOM 943 CD2 HIS A 150 14. .727 4. .845 40. .481 1. .00 27. .22 C

ATOM 944 CE1 HIS A 150 14. .565 6. .730 41. .609 1. .00 26. .91 C

ATOM 945 NE2 HIS A 150 13. .864 5. .726 41. .050 1. .00 28. .35 N

ATOM 946 N CYS A 151 20. .306 5. , 706 38. , 982 1. , 00 30. , 70 N

ATOM 947 CA CYS A 151 21. .685 5. .433 38. .563 1. .00 30. .61 C

ATOM 948 C CYS A 151 22. .714 5. .702 39. .663 1. .00 31. .30 C

ATOM 949 O CYS A 151 22. .644 6. .709 40. .391 1. , 00 29. , 22 O

ATOM 950 CB CYS A 151 22. .044 6. .311 37. .362 1. .00 27. .85 C

ATOM 951 SG CYS A 151 21. .858 8. .076 37. .725 1. .00 27. .71 S

ATOM 952 N LYS A 152 23. .665 4. .784 39. .760 1. .00 35. .54 N

ATOM 953 CA LYS A 152 24. .879 4. .973 40. .541 1. .00 37. .13 C

ATOM 954 C LYS A 152 26. .027 4. .549 39. .639 1. .00 36. .31 C

ATOM 955 O LYS A 152 26. .098 3. .390 39. .218 1. .00 34. .07 O

ATOM 956 CB LYS A 152 24. .846 4. .125 41. .812 1. .00 42. .49 C

ATOM 957 CG LYS A 152 26. .071 4. .306 42. .713 1. .00 47. .76 c

ATOM 958 CD LYS A 152 26. .184 3. .177 43. .728 1. .00 49. .18 c

ATOM 959 CE LYS A 152 27. .408 3. .351 44. .607 1. .00 52. .43 c

ATOM 960 NZ LYS A 152 27. .503 2. .275 45. .631 1. .00 56. .96 N

ATOM 961 N ASN A 153 26. .899 5. .506 39. .327 1. .00 35. .42 N ATOM 962 CA ASN A 153 28..004 5..316 38..383 1..00 35..87 C

ATOM 963 C ASN A 153 27. .577 4. .752 37. .035 1. .00 34. .91 C

ATOM 964 O ASN A 153 28. .266 3. .895 36. .465 1. .00 37. .15 O

ATOM 965 CB ASN A 153 29. .142 4. .478 39. .001 1. .00 37. .99 C

ATOM 966 CG ASN A 153 29. .698 5. .090 40. .282 1. .00 40. .64 C

ATOM 967 OD1 ASN A 153 29. .822 4. .416 41. .308 1. .00 43. .50 O

ATOM 968 ND2 ASN A 153 30. .021 6. .368 40. .233 1. .00 43. .76 N

ATOM 969 N SER A 154 26. .449 5. .234 36. .512 1. .00 32. .94 N

ATOM 970 CA SER A 154 25. .947 4. .732 35. .237 1. .00 30. .25 C

ATOM 971 C SER A 154 25. .281 5. .833 34. .421 1. .00 31. .77 C

ATOM 972 O SER A 154 24. .253 6. .374 34. .828 1. .00 31. .97 O

ATOM 973 CB SER A 154 24. .947 3. .600 35. .487 1. .00 29. .65 C

ATOM 974 OG SER A 154 24. .421 3. , 082 34. , 278 1. , 00 28. , 55 O

ATOM 975 N ILE A 155 25. .860 6. .149 33. .268 1. .00 30. .52 N

ATOM 976 CA ILE A 155 25. .242 7. .085 32. .323 1. .00 30. .65 C

ATOM 977 C ILE A 155 23. .912 6. .513 31. .837 1. , 00 29. , 93 C

ATOM 978 O ILE A 155 23. .830 5. .320 31. .496 1. .00 29. .99 O

ATOM 979 CB ILE A 155 26. .131 7. .323 31. .075 1. .00 29. .26 C

ATOM 980 CGI ILE A 155 27. .557 7. .754 31. .461 1. .00 30. .80 c

ATOM 981 CG2 ILE A 155 25. .476 8. .295 30. .108 1. .00 28. .70 c

ATOM 982 CD1 ILE A 155 27. .650 8. .803 32. .543 1. .00 31. .04 c

ATOM 983 N ALA A 156 22. .889 7. .367 31. .787 1. .00 27. .72 N

ATOM 984 CA ALA A 156 21. .567 6. .996 31. .257 1. .00 24. .71 C

ATOM 985 C ALA A 156 21. .287 7. .617 29. .912 1. .00 24. .06 C

ATOM 986 O ALA A 156 20. .673 7. .002 29. .043 1. .00 25. .32 O

ATOM 987 CB ALA A 156 20. .484 7. .419 32. .238 1. .00 23. .50 c

ATOM 988 N TYR A 157 21. .698 8. .864 29. .732 1. .00 24. .66 N

ATOM 989 CA TYR A 157 21. .414 9. , 547 28. , 479 1. , 00 25. , 38 C

ATOM 990 C TYR A 157 22. .653 10. .271 27. .990 1. .00 26. .69 C

ATOM 991 O TYR A 157 23. .350 9. .768 27. .133 1. .00 27. .87 O

ATOM 992 CB TYR A 157 20. .219 10. .494 28. .630 1. , 00 22. , 87 c

ATOM 993 CG TYR A 157 19. .912 11. .350 27. .403 1. .00 23. .23 c

ATOM 994 CD1 TYR A 157 19. .460 10. .777 26. .208 1. .00 22. .20 c

ATOM 995 CD2 TYR A 157 20. .033 12. .745 27. .462 1. .00 22. .66 c

ATOM 996 CE1 TYR A 157 19. .164 11. .567 25. .103 1. .00 22. .88 c

ATOM 997 CE2 TYR A 157 19. .722 13. .540 26. .376 1. .00 22. .52 c

ATOM 998 CZ TYR A 157 19. .295 12. .952 25. .202 1. .00 22. .79 c

ATOM 999 OH TYR A 157 19. .013 13. .761 24. .145 1. .00 21. .41 0

HETATM 1000 N MSE A 158 22. .931 11. .434 28. .572 1. .00 28. .52 N

HETATM 1001 CA MSE A 158 24. .092 12. .228 28. .223 1. .00 31. .08 C

HETATM 1002 C MSE A 158 25. .292 11. .829 29. .059 1. .00 30. .13 c

HETATM 1003 O MSE A 158 25. .181 11. .625 30. .270 1. .00 27. .12 0

HETATM 1004 CB MSE A 158 23. .663 13. , 664 28. , 524 1. , 00 30. , 95 c

HETATM 1005 CG MSE A 158 24. .790 14. .675 28. .455 1. .00 38. .01 c

HETATM 1006 SE MSE A 158 25. .108 15. .044 26. .549 1. .00 47. .08 SE

HETATM 1007 CE MSE A 158 23. .837 16. .551 26. .430 1. , 00 42. , 32 C

ATOM 1008 N ASP A 159 26. .444 11. .724 28. .407 1. .00 31. .42 N

ATOM 1009 CA ASP A 159 27. .733 11. .539 29. .084 1. .00 33. .90 C

ATOM 1010 C ASP A 159 28. .355 12. .932 29. .191 1. .00 35. .33 C

ATOM 1011 O ASP A 159 28. .687 13. .525 28. .166 1. .00 35. .40 O

ATOM 1012 CB ASP A 159 28. .627 10. .619 28. .236 1. .00 36. .42 C

ATOM 1013 CG ASP A 159 29. .978 10. .268 28. .910 1. .00 37. .37 c

ATOM 1014 OD1 ASP A 159 30. .667 11. .139 29. .489 1. .00 39. .05 0

ATOM 1015 OD2 ASP A 159 30. .363 9. .090 28. .827 1. .00 39. .80 0

ATOM 1016 N AGLN A 160 28. .492 13. .472 30. .390 0. .50 37. .38 N

ATOM 1017 CA AGLN A 160 29. .004 14. .832 30. .522 0. .50 42. .11 C

ATOM 1018 C AGLN A 160 30. .437 14. .998 30. .025 0. .50 44. .21 C

ATOM 1019 O AGLN A 160 30. .755 15. .999 29. .402 0. .50 44. .22 O

ATOM 1020 CB AGLN A 160 28. .848 15. .368 31. .943 0. .50 46. .01 c

ATOM 1021 CG AGLN A 160 28. .477 16. .843 32. .019 0. .50 49. .72 c

ATOM 1022 CD AGLN A 160 27. .147 17. .182 31. .340 0. .50 57. .36 c ATOM 1023 OE1AGLN A 160 26..085 16..703 31..738 0..50 61..87 O

ATOM 1024 NE2AGLN A 160 27. .208 18. .028 30. .316 0. .50 57. .99 N

ATOM 1025 N BGLN A 160 28. .517 13. .487 30. .380 0. .50 37. .38 N

ATOM 1026 CA BGLN A 160 29. .021 14. .840 30. .535 0. .50 42. .11 C

ATOM 1027 C BGLN A 160 30. .449 15. .009 30. .032 0. .50 44. .21 C

ATOM 1028 O BGLN A 160 30. .756 15. .985 29. .366 0. .50 44. .22 O

ATOM 1029 CB BGLN A 160 28. .920 15. .279 31. .989 0. .50 46. .01 C

ATOM 1030 CG BGLN A 160 29. .157 16. .753 32. .205 0. .50 49. .72 C

ATOM 1031 CD BGLN A 160 30. .282 17. .013 33. .177 0. .50 57. .36 C

ATOM 1032 OE1BGLN A 160 30. .064 17. , 515 34. , 274 0. , 50 61. , 87 O

ATOM 1033 NE2BGLN A 160 31. .495 16. .672 32. .775 0. .50 57. .99 N

ATOM 1034 N ALA A 161 31. .294 14. .021 30. .295 1. .00 42. .71 N

ATOM 1035 CA ALA A 161 32. .683 14. .111 29. .874 1. , 00 44. ,81 C

ATOM 1036 C ALA A 161 32. .885 14. .169 28. .365 1. .00 43. .74 C

ATOM 1037 O ALA A 161 33. .659 14. .973 27. .880 1. .00 46. .68 O

ATOM 1038 CB ALA A 161 33. .477 12. .962 30. .457 1. .00 44. .23 C

ATOM 1039 N SER A 162 32. .174 13. .339 27. .623 1. .00 42. .24 N

ATOM 1040 CA SER A 162 32. .255 13. .370 26. .155 1. .00 39. .22 C

ATOM 1041 C SER A 162 31. .330 14. .408 25. .531 1. .00 37. .42 C

ATOM 1042 O SER A 162 31. .627 14. .945 24. .474 1. .00 38. .34 O

ATOM 1043 CB SER A 162 31. .932 12. .002 25. .565 1. .00 39. .94 C

ATOM 1044 OG SER A 162 30. .539 11. .736 25. .674 1. .00 44. .77 0

ATOM 1045 N GLY A 163 30. .196 14. .665 26. .171 1. .00 35. .06 N

ATOM 1046 CA GLY A 163 29. .197 15. .580 25. .617 1. .00 33. .80 C

ATOM 1047 C GLY A 163 28. .293 14. .933 24. .574 1. .00 33. .31 C

ATOM 1048 O GLY A 163 27. .697 15. .619 23. .744 1. .00 34. .24 O

ATOM 1049 N ASN A 164 28. .180 13. .612 24. .603 1. .00 29. .74 N

ATOM 1050 CA ASN A 164 27. .286 12. .934 23. .679 1. .00 29. .60 C

ATOM 1051 C ASN A 164 26. .305 11. .960 24. .339 1. .00 27. .78 C

ATOM 1052 O ASN A 164 26. .393 11. .675 25. .529 1. .00 28. .47 O

ATOM 1053 CB ASN A 164 28. .085 12. .240 22. .559 1. .00 28. .42 C

ATOM 1054 CG ASN A 164 28. .908 11. .058 23. .059 1. .00 29. .24 c

ATOM 1055 OD1 ASN A 164 28. .437 10. .242 23. .855 1. .00 29. .32 0

ATOM 1056 ND2 ASN A 164 30. .146 10. .960 22. .583 1. .00 29. .06 N

ATOM 1057 N VAL A 165 25. .400 11. .427 23. .530 1. .00 28. .05 N

ATOM 1058 CA VAL A 165 24. .399 10. .475 23. .993 1. .00 27. .83 C

ATOM 1059 C VAL A 165 24. .592 9. .057 23. .404 1. .00 29. .74 C

ATOM 1060 O VAL A 165 23. .639 8. , 255 23. , 355 1. , 00 27. , 61 O

ATOM 1061 CB VAL A 165 22. .979 10. .995 23. .681 1. .00 26. .75 C

ATOM 1062 CGI VAL A 165 22. .716 12. .312 24. .413 1. .00 25. .04 C

ATOM 1063 CG2 VAL A 165 22. .769 11. .138 22. .172 1. .00 24. .71 C

ATOM 1064 N LYS A 166 25. .824 8. .742 22. .985 1. .00 30. .63 N

ATOM 1065 CA LYS A 166 26. .147 7. .416 22. .432 1. .00 32. .12 C

ATOM 1066 C LYS A 166 25. .979 6. .283 23. .454 1. .00 33. .40 C

ATOM 1067 O LYS A 166 25. .692 5. .155 23. .077 1. .00 34. .96 O

ATOM 1068 CB LYS A 166 27. .561 7. .392 21. .823 1. .00 33. .99 C

ATOM 1069 CG LYS A 166 27. .668 8. .154 20. .505 1. .00 34. .87 c

ATOM 1070 N LYS A 167 26. .135 6. .599 24. .740 1. .00 33. .89 N

ATOM 1071 CA LYS A 167 25. .939 5. .634 25. .827 1. .00 34. .89 C

ATOM 1072 C LYS A 167 24. .505 5. , 586 26. , 390 1. , 00 33. , 75 C

ATOM 1073 O LYS A 167 24. .257 4. .945 27. .416 1. .00 32. .41 O

ATOM 1074 CB LYS A 167 26. .932 5. .920 26. .964 1. .00 37. .60 C

ATOM 1075 CG LYS A 167 28. .398 5. .747 26. .571 1. , 00 39. , 87 c

ATOM 1076 CD LYS A 167 29. .315 6. .016 27. .755 1. .00 41. .55 c

ATOM 1077 CE LYS A 167 30. .776 5. .950 27. .336 1. .00 43. .02 c

ATOM 1078 NZ LYS A 167 31. .647 6. .429 28. .442 1. .00 44. .86 N

ATOM 1079 N ALA A 168 23. .576 6. .261 25. .712 1. .00 31. .99 N

ATOM 1080 CA ALA A 168 22. .181 6. .361 26. .156 1. .00 29. .52 C

ATOM 1081 C ALA A 168 21. .472 5. .018 26. .107 1. .00 29. .47 C

ATOM 1082 O ALA A 168 21. .564 4. .298 25. .114 1. .00 27. .24 O

ATOM 1083 CB ALA A 168 21. .423 7. .377 25. .306 1. .00 29. .14 C ATOM 1084 N LEU A 169 20..741 4 ,.697 27 ,.175 1 ,.00 27 ,.84 N

ATOM 1085 CA LEU A 169 19. .916 3, .492 27 , .201 1 , .00 25, .96 C

ATOM 1086 C LEU A 169 18. .829 3, .471 26, .118 1 , .00 26, .34 C

ATOM 1087 O LEU A 169 18. .587 4. .467 25. .447 1. .00 26. .73 O

ATOM 1088 CB LEU A 169 19. .318 3, .296 28 , .589 1 , .00 26, .61 C

ATOM 1089 CG LEU A 169 18. .372 4 , .344 29, .172 1 , .00 25, .99 C

ATOM 1090 CD1 LEU A 169 16. .967 4 , .193 28 , .601 1. .00 25. .00 C

ATOM 1091 CD2 LEU A 169 18. .343 4 , .180 30 , .676 1 , .00 27 , .56 c

ATOM 1092 N LYS A 170 18. .208 2 , .310 25, .939 1 , .00 27 , .11 N

ATOM 1093 CA LYS A 170 17. .185 2 , .078 24 , .933 1 , .00 27 , .45 C

ATOM 1094 C LYS A 170 15. .954 1 , .534 25, .639 1 , .00 27 , .78 C

ATOM 1095 O LYS A 170 16. .066 0 , .937 26, .714 1 , .00 26, .95 O

ATOM 1096 CB LYS A 170 17. .646 1 , .000 23, .956 1 , .00 30 , .63 C

ATOM 1097 CG LYS A 170 18. .672 1 , .444 22 , .922 1 , .00 35, .94 c

ATOM 1098 CD LYS A 170 18. .661 0 , .546 21 , .680 1 , .00 36, .03 c

ATOM 1099 CE LYS A 170 19. .362 -0. .797 21. .889 1. .00 36. .77 c

ATOM 1100 NZ LYS A 170 19. .194 -1. .595 20. .643 1. .00 36. .43 N

ATOM 1101 N LEU A 171 14. .787 1 , .715 25, .026 1 , .00 27 , .28 N

ATOM 1102 CA LEU A 171 13. .546 1 , .148 25, .565 1 , .00 27 , .69 C

ATOM 1103 C LEU A 171 12. .850 0 , .251 24 , .552 1 , .00 27 , .39 C

ATOM 1104 O LEU A 171 12. .979 0 , .441 23, .348 1 , .00 28 , .03 O

ATOM 1105 CB LEU A 171 12. .593 2 , .262 26, .033 1 , .00 25, .80 C

ATOM 1106 CG LEU A 171 13. .123 3, .198 27 , .137 1 , .00 25, .84 C

ATOM 1107 CD1 LEU A 171 12. .253 4 , .446 27 , .281 1 , .00 26, .26 C

ATOM 1108 CD2 LEU A 171 13. .220 2 , .484 28 , .463 1 , .00 23, .60 C

HETATM 1109 N MSE A 172 12. .097 -0. .720 25. .054 1. .00 28. .89 N

HETATM 1110 CA MSE A 172 11. .332 -1. .619 24. .203 1. .00 30. .67 C

HETATM 1111 C MSE A 172 9. .838 -1. .364 24. .243 1. .00 30. .12 C

HETATM 1112 O MSE A 172 9. .186 -1. .496 25. .290 1. .00 30. .08 O

HETATM 1113 CB MSE A 172 11. .650 -3. .039 24. .649 1. .00 36. .24 C

HETATM 1114 CG MSE A 172 10. .826 -4. .047 23. .866 1. .00 42. .73 c

HETATM 1115 SE MSE A 172 11. .714 -4. .377 22. .153 1. .00 63. .84 SE

HETATM 1116 CE MSE A 172 11. .329 -2. .740 21. .172 1. .00 49. .57 C

ATOM 1117 N GLY A 173 9. .276 -1. .044 23. .085 1. .00 29. .13 N

ATOM 1118 CA GLY A 173 7. .842 -0. .830 22. .954 1. .00 31. .09 C

ATOM 1119 C GLY A 173 7. .070 -2. .096 22. .637 1. .00 32. .26 C

ATOM 1120 O GLY A 173 7. .616 -3. .186 22. .681 1. .00 31. .11 O

ATOM 1121 N SER A 174 5. .804 -1. .930 22. .277 1. .00 33. .30 N

ATOM 1122 CA SER A 174 4. .876 -3. .034 22. .177 1. .00 36. .83 C

ATOM 1123 C SER A 174 4. .652 -3. .555 20. .769 1. .00 41. .68 C

ATOM 1124 O SER A 174 4. .064 -4. .621 20. .613 1. .00 47. .45 O

ATOM 1125 CB SER A 174 3. .543 -2. .657 22. .815 1. .00 34. .86 C

ATOM 1126 OG SER A 174 3. .600 -2. .848 24. .219 1. .00 32. .97 0

ATOM 1127 N ASN A 175 5. .100 -2. .818 19. .754 1. .00 43. .56 N

ATOM 1128 CA ASN A 175 5. .108 -3. .349 18. .381 1. .00 48. .40 C

ATOM 1129 C ASN A 175 6. .497 -3. .810 17. .950 1. .00 50. .02 C

ATOM 1130 O ASN A 175 6. .898 -3. .588 16. .815 1. .00 52. .65 O

ATOM 1131 CB ASN A 175 4. .537 -2. .338 17. .376 1. .00 47. .65 C

ATOM 1132 CG ASN A 175 3. .191 -2. .768 16. .822 1. .00 48. .34 c

ATOM 1133 OD1 ASN A 175 2. .671 -3. .826 17. .175 1. .00 49. .64 0

ATOM 1134 ND2 ASN A 175 2. .622 -1. .951 15. .943 1. .00 46. .50 N

ATOM 1135 N GLU A 176 7. .215 -4. .443 18. .878 1. .00 51. .19 N

ATOM 1136 CA GLU A 176 8. .639 -4. .791 18. .732 1. .00 52. .28 C

ATOM 1137 C GLU A 176 9. .573 -3. .620 18. .342 1. .00 54. .18 C

ATOM 1138 O GLU A 176 10. .755 -3. .840 18. .052 1. .00 58. .15 O

ATOM 1139 CB GLU A 176 8. .815 -5. .979 17. .778 1. .00 53. .86 C

ATOM 1140 N GLY A 177 9. .051 -2. .390 18. .345 1. .00 48. .66 N

ATOM 1141 CA GLY A 177 9. .844 -1. .200 18. .024 1. .00 45. .19 C

ATOM 1142 C GLY A 177 10. .637 -0. .689 19. .219 1. .00 41. .71 C

ATOM 1143 O GLY A 177 10. .185 -0. .794 20. .351 1. .00 45. .40 O

ATOM 1144 N GLU A 178 11. .823 -0. .144 18. .972 1. .00 39. .28 N ATOM 1145 CA GLU A 178 12..689 0..397 20..029 1 ,.00 36..92 C

ATOM 1146 C GLU A 178 12. .565 1. .907 20. .140 1. .00 33. , 07 C

ATOM 1147 O GLU A 178 12. .378 2. .579 19. .132 1 , .00 35. .37 O

ATOM 1148 CB GLU A 178 14. .149 0. .043 19. .748 1 , .00 37. .32 C

ATOM 1149 CG GLU A 178 14. .519 -1. , 375 20. , 147 1. .00 38. , 02 C

ATOM 1150 CD GLU A 178 15. .886 -1. ,796 19. , 646 1. .00 39. , 24 C

ATOM 1151 OE1 GLU A 178 16. .549 -1. , 022 18. , 925 1. .00 42. , 65 O

ATOM 1152 OE2 GLU A 178 16. .296 -2. , 921 19. , 957 1. .00 41. , 95 O

ATOM 1153 N PHE A 179 12. .673 2. .435 21. .358 1 , .00 28. .41 N

ATOM 1154 CA PHE A 179 12. .723 3. .886 21. .546 1 , .00 26. .75 C

ATOM 1155 C PHE A 179 14. .146 4. .249 21. .928 1 , .00 25. .18 C

ATOM 1156 O PHE A 179 14. .728 3. .616 22. .792 1 , .00 23. .85 O

ATOM 1157 CB PHE A 179 11. .713 4. .382 22. .610 1 , .00 24. .72 C

ATOM 1158 CG PHE A 179 10. .330 3. , 822 22. , 434 1. .00 23. , 22 c

ATOM 1159 CD1 PHE A 179 9. .700 3. .862 21. .191 1 , .00 22. .90 c

ATOM 1160 CD2 PHE A 179 9. .659 3. .247 23. .503 1 , .00 23. .10 c

ATOM 1161 CE1 PHE A 179 8. .431 3. .331 21. .022 1 , .00 22. .74 c

ATOM 1162 CE2 PHE A 179 8. .388 2. .717 23. .343 1 , .00 23. .24 c

ATOM 1163 CZ PHE A 179 7. .775 2. .753 22. .101 1 , .00 23. .27 c

ATOM 1164 N LYS A 180 14. .693 5. .271 21. .281 1 , .00 25. .63 N

ATOM 1165 CA LYS A 180 16. .116 5. .565 21. .387 1 , .00 27. .44 C

ATOM 1166 C LYS A 180 16. .408 7. .060 21. .531 1 , .00 26. .39 c

ATOM 1167 O LYS A 180 15. .544 7. .888 21. .286 1 , .00 27. .17 0

ATOM 1168 CB LYS A 180 16. .840 5. .016 20. .146 1 , .00 28. .24 c

ATOM 1169 CG LYS A 180 16. .877 3. .502 20. .054 1 , .00 28. .51 c

ATOM 1170 CD LYS A 180 18. .050 3. , 035 19. ,196 1. .00 30. , 48 c

ATOM 1171 CE LYS A 180 17. .732 3. .070 17. .709 1 , .00 32. .03 c

ATOM 1172 NZ LYS A 180 18. .786 2. .328 16. .958 1 , .00 36. .32 N

ATOM 1173 N ALA A 181 17. .637 7. .389 21. .914 1. .00 26. , 05 N

ATOM 1174 CA ALA A 181 18. .090 8. .774 21. .984 1 , .00 26. .11 C

ATOM 1175 C ALA A 181 18. .098 9. .447 20. .614 1 , .00 26. .47 C

ATOM 1176 O ALA A 181 17. .834 10. .640 20. .503 1 , .00 24. .27 O

ATOM 1177 CB ALA A 181 19. .471 8. .836 22. .601 1 , .00 25. .61 C

ATOM 1178 N GLU A 182 18. .415 8. .674 19. .576 1 , .00 28. .77 N

ATOM 1179 CA GLU A 182 18. .538 9. .200 18. .213 1 , .00 31. .55 C

ATOM 1180 C GLU A 182 17. .933 8. .240 17. .198 1 , .00 32. .74 C

ATOM 1181 O GLU A 182 17. .503 7. .132 17. .550 1 , .00 32. .11 O

ATOM 1182 CB GLU A 182 20. .006 9. .435 17. .875 1 , .00 34. .77 C

ATOM 1183 CG GLU A 182 20. .626 10. .600 18. .631 1 , .00 38. .08 c

ATOM 1184 CD GLU A 182 22. .105 10. .767 18. .348 1 , .00 39. .28 c

ATOM 1185 OE1 GLU A 182 22. .913 10. .024 18. .935 1 , .00 38. .28 0

ATOM 1186 OE2 GLU A 182 22. .462 11. .664 17. .557 1 , .00 42. .55 0

ATOM 1187 N GLY A 183 17. .922 8. .670 15. .937 1 , .00 34. .41 N

ATOM 1188 CA GLY A 183 17. .452 7. .854 14. .833 1 , .00 33. .50 C

ATOM 1189 C GLY A 183 16. .105 8. .351 14. .385 1 , .00 37. .13 C

ATOM 1190 O GLY A 183 15. .764 9. .514 14. .606 1 , .00 40. .22 0

ATOM 1191 N ASN A 184 15. .290 7. .437 13. .890 1 , .00 38. .52 N

ATOM 1192 CA ASN A 184 14. .029 7. .829 13. .336 1 , .00 39. .10 C

ATOM 1193 C ASN A 184 13. .354 8. .619 14. .422 1 , .00 38. .71 C

ATOM 1194 O ASN A 184 13. .112 8. .132 15. .510 1 , .00 35. .72 O

ATOM 1195 CB ASN A 184 13. .225 6. .562 13. .045 1 , .00 40. .61 C

ATOM 1196 CG ASN A 184 11. .853 6. .843 12. .479 1 , .00 42. .90 c

ATOM 1197 OD1 ASN A 184 11. .360 7. .958 12. .533 1 , .00 43. .94 0

ATOM 1198 ND2 ASN A 184 11. .229 5. .819 11. .935 1 , .00 41. .98 N

ATOM 1199 N SER A 185 13. .007 9. .842 14. .074 1 , .00 39. .01 N

ATOM 1200 CA SER A 185 12. .397 10. .785 15. .002 1 , .00 38. .01 C

ATOM 1201 C SER A 185 10. .970 10. , 396 15. , 434 1. .00 35. , 44 C

ATOM 1202 O SER A 185 10. .418 10. .981 16. .355 1 , .00 36. .94 O

ATOM 1203 CB SER A 185 12. .450 12. .211 14. .429 1 , .00 38. .68 C

ATOM 1204 OG SER A 185 11. .355 12. .479 13. .575 1. .00 41. ,46 O

ATOM 1205 N LYS A 186 10. .388 9. .399 14. .779 1 , .00 33. .56 N ATOM 1206 CA LYS A 186 9..120 8..832 15..221 1..00 33..24 C

ATOM 1207 C LYS A 186 9. .293 7. .881 16. .413 1. .00 31. .62 C

ATOM 1208 O LYS A 186 8. .343 7. .600 17. .133 1. .00 30. .98 O

ATOM 1209 CB LYS A 186 8. .424 8. .110 14. .058 1. .00 36. .35 C

ATOM 1210 CG LYS A 186 7. .754 9. .042 13. .055 1. .00 36. .45 C

ATOM 1211 N PHE A 187 10. .507 7. .386 16. .612 1. .00 29. .30 N

ATOM 1212 CA PHE A 187 10. .776 6. .394 17. .642 1. .00 29. .97 C

ATOM 1213 C PHE A 187 11. .804 6. .849 18. .684 1. .00 28. .43 C

ATOM 1214 O PHE A 187 12. .318 6. .031 19. .435 1. .00 30. .32 O

ATOM 1215 CB PHE A 187 11. .174 5. .052 17. .012 1. .00 32. .01 C

ATOM 1216 CG PHE A 187 10. .037 4. .359 16. .287 1. .00 33. .88 c

ATOM 1217 CD1 PHE A 187 9. .641 4. .772 15. .019 1. .00 34. .82 c

ATOM 1218 CD2 PHE A 187 9. .369 3. .279 16. .877 1. .00 37. .09 c

ATOM 1219 CE1 PHE A 187 8. .587 4. .147 14. .354 1. .00 36. .08 c

ATOM 1220 CE2 PHE A 187 8. .325 2. .637 16. .216 1. .00 37. .34 c

ATOM 1221 CZ PHE A 187 7. .928 3. .077 14. .951 1. .00 37. .01 c

ATOM 1222 N THR A 188 12. .086 8. .152 18. .738 1. .00 26. .02 N

ATOM 1223 CA THR A 188 12. .946 8. .695 19. .787 1. .00 25. .89 C

ATOM 1224 C THR A 188 12. .136 9. .058 21. .049 1. .00 24. .32 C

ATOM 1225 O THR A 188 11. .039 9. .597 20. .969 1. .00 23. .61 0

ATOM 1226 CB THR A 188 13. .710 9. , 958 19. , 328 1. , 00 26. , 67 c

ATOM 1227 OG1 THR A 188 12. .779 10. .924 18. .842 1. .00 26. .83 0

ATOM 1228 CG2 THR A 188 14. .714 9. .626 18. .209 1. .00 26. .85 c

ATOM 1229 N TYR A 189 12. .691 8. .773 22. .213 1. , 00 22. , 73 N

ATOM 1230 CA TYR A 189 12. .080 9. .228 23. .442 1. .00 23. .15 C

ATOM 1231 C TYR A 189 12. .498 10. .665 23. .715 1. .00 22. .81 C

ATOM 1232 O TYR A 189 13. .327 11. .191 22. .988 1. .00 22. .93 0

ATOM 1233 CB TYR A 189 12. .436 8. .298 24. .598 1. .00 21. .63 c

ATOM 1234 CG TYR A 189 13. .908 8. .020 24. .801 1. .00 22. .01 c

ATOM 1235 CD1 TYR A 189 14. .808 9. .053 25. .082 1. .00 21. .83 c

ATOM 1236 CD2 TYR A 189 14. .399 6. .710 24. .774 1. .00 21. .72 c

ATOM 1237 CE1 TYR A 189 16. .146 8. .798 25. .295 1. .00 20. .69 c

ATOM 1238 CE2 TYR A 189 15. .743 6. .447 24. .997 1. .00 21. .68 c

ATOM 1239 CZ TYR A 189 16. .608 7. .498 25. .256 1. .00 21. .85 c

ATOM 1240 OH TYR A 189 17. .947 7. .254 25. .487 1. .00 22. .89 0

ATOM 1241 N THR A 190 11. .915 11. , 314 24. , 723 1. , 00 21. , 62 N

ATOM 1242 CA THR A 190 12. .482 12. .581 25. .185 1. .00 23. .21 c

ATOM 1243 C THR A 190 12. .949 12. .444 26. .630 1. .00 22. .79 c

ATOM 1244 O THR A 190 12. .520 11. .541 27. .349 1. , 00 24. ,41 0

ATOM 1245 CB THR A 190 11. .528 13. .797 25. .047 1. .00 24. .64 c

ATOM 1246 OG1 THR A 190 10. .459 13. .677 25. .988 1. .00 24. .99 0

ATOM 1247 CG2 THR A 190 10. .963 13. .946 23. .609 1. .00 23. .82 c

ATOM 1248 N VAL A 191 13. .833 13. .340 27. .047 1. .00 21. .21 N

ATOM 1249 CA VAL A 191 14. .429 13. .281 28. .384 1. .00 19. .89 C

ATOM 1250 C VAL A 191 13. .903 14. .481 29. .199 1. .00 19. .50 c

ATOM 1251 O VAL A 191 14. .038 15. .636 28. .776 1. .00 18. .93 0

ATOM 1252 CB VAL A 191 15. .968 13. .266 28. .270 1. .00 20. .29 c

ATOM 1253 CGI VAL A 191 16. .641 13. .342 29. .632 1. .00 19. .81 c

ATOM 1254 CG2 VAL A 191 16. .424 12. .008 27. .527 1. .00 20. .38 c

ATOM 1255 N LEU A 192 13. .284 14. .196 30. .344 1. .00 18. .53 N

ATOM 1256 CA LEU A 192 12. .613 15. , 226 31. , 142 1. , 00 19. ,26 C

ATOM 1257 C LEU A 192 13. .520 15. .773 32. .257 1. .00 19. .19 C

ATOM 1258 O LEU A 192 13. .277 16. .846 32. .780 1. .00 18. .51 0

ATOM 1259 CB LEU A 192 11. .289 14. .690 31. .725 1. , 00 18. ,16 c

ATOM 1260 CG LEU A 192 10. .187 14. .197 30. .753 1. .00 19. .60 c

ATOM 1261 CD1 LEU A 192 8. .933 13. .806 31. .535 1. .00 19. .35 c

ATOM 1262 CD2 LEU A 192 9. .825 15. .209 29. .654 1. .00 17. .79 c

ATOM 1263 N GLU A 193 14. .534 15. .005 32. .628 1. .00 20. .21 N

ATOM 1264 CA GLU A 193 15. .581 15. .429 33. .562 1. .00 22. .61 C

ATOM 1265 C GLU A 193 16. .709 14. .392 33. .486 1. .00 24. .10 C

ATOM 1266 O GLU A 193 16. .449 13. .210 33. .201 1. .00 24. .92 0 ATOM 1267 CB GLU A 193 15..052 15..576 34..997 1..00 24..25 C

ATOM 1268 CG GLU A 193 14. .658 14. .281 35. .674 1. .00 26. .27 C

ATOM 1269 CD GLU A 193 14. .229 14. .467 37. .124 1. .00 30. .48 c

ATOM 1270 OE1 GLU A 193 13. .023 14. .714 37. .351 1. .00 32. .48 0

ATOM 1271 OE2 GLU A 193 15. .085 14. .338 38. .046 1. .00 31. .16 0

ATOM 1272 N ASP A 194 17. .949 14. .823 33. .714 1. .00 24. .68 N

ATOM 1273 CA ASP A 194 19. .106 13. .938 33. .511 1. .00 25. .65 C

ATOM 1274 C ASP A 194 20. .185 14. .214 34. .550 1. .00 28. .19 C

ATOM 1275 O ASP A 194 21. .047 15. .083 34. .354 1. .00 28. .36 O

ATOM 1276 CB ASP A 194 19. .644 14. .075 32. .079 1. .00 24. .36 c

ATOM 1277 CG ASP A 194 20. .661 12. .993 31. .714 1. .00 24. .60 c

ATOM 1278 OD1 ASP A 194 20. .935 12. .117 32. .549 1. .00 24. .81 0

ATOM 1279 OD2 ASP A 194 21. .204 13. .017 30. .585 1. .00 22. .41 0

ATOM 1280 N GLY A 195 20. .114 13. .480 35. .664 1. .00 28. .67 N

ATOM 1281 CA GLY A 195 21. .100 13. .581 36. .749 1. .00 28. .04 C

ATOM 1282 C GLY A 195 22. .111 12. .435 36. .751 1. .00 27. .54 C

ATOM 1283 O GLY A 195 22. .839 12. .245 37. .715 1. .00 28. .82 0

ATOM 1284 N CYS A 196 22. .159 11. , 675 35. ,666 1. , 00 26. , 17 N

ATOM 1285 CA CYS A 196 23. .005 10. .493 35. .593 1. .00 26. .22 C

ATOM 1286 C CYS A 196 24. .236 10. .716 34. .730 1. .00 27. .10 C

ATOM 1287 O CYS A 196 24. .851 9. .752 34. .299 1. , 00 28. ,09 O

ATOM 1288 CB CYS A 196 22. .203 9. .302 35. .037 1. .00 24. .62 C

ATOM 1289 SG CYS A 196 20. .862 8. .786 36. .096 1. .00 20. .87 s

ATOM 1290 N THR A 197 24. .607 11. .980 34. .500 1. .00 27. .88 N

ATOM 1291 CA THR A 197 25. .609 12. .332 33. .466 1. .00 28. .49 C

ATOM 1292 C THR A 197 27. .079 12. .036 33. .840 1. .00 30. .15 C

ATOM 1293 O THR A 197 27. .922 11. .911 32. .947 1. .00 32. .13 O

ATOM 1294 CB THR A 197 25. .480 13. .809 32. .991 1. .00 27. .00 c

ATOM 1295 OG1 THR A 197 25. .849 14. .692 34. .059 1. .00 24. .56 0

ATOM 1296 CG2 THR A 197 24. .040 14. .134 32. .533 1. .00 24. .94 c

ATOM 1297 N LYS A 198 27. .383 11. .934 35. .134 1. .00 32. .77 N

ATOM 1298 CA LYS A 198 28. .749 11. .588 35. .622 1. .00 35. .38 C

ATOM 1299 C LYS A 198 28. .727 10. .377 36. .542 1. .00 34. .86 C

ATOM 1300 O LYS A 198 27. .741 10. .162 37. .240 1. .00 35. .04 O

ATOM 1301 CB LYS A 198 29. .323 12. .734 36. .463 1. .00 36. .68 c

ATOM 1302 CG LYS A 198 29. .700 14. .006 35. .733 1. .00 39. .25 c

ATOM 1303 CD LYS A 198 29. .841 15. .149 36. .734 1. .00 39. .25 c

ATOM 1304 N HIS A 199 29. .820 9. .615 36. .595 1. .00 37. .97 N

ATOM 1305 CA HIS A 199 29. .999 8. .630 37. .678 1. .00 38. .79 C

ATOM 1306 C HIS A 199 30. .412 9. .388 38. .898 1. .00 38. .55 C

ATOM 1307 O HIS A 199 31. .430 10. .051 38. .876 1. .00 41. .69 O

ATOM 1308 CB HIS A 199 31. .033 7. .553 37. .326 1. .00 37. .82 c

ATOM 1309 CG HIS A 199 30. .672 6. .720 36. .107 1. .00 38. .85 c

ATOM 1310 ND1 HIS A 199 31. .494 5. .778 35. .602 1. .00 38. .05 N

ATOM 1311 CD2 HIS A 199 29. .542 6. .736 35. .278 1. .00 40. .80 C

ATOM 1312 CE1 HIS A 199 30. .922 5. , 207 34. , 521 1. , 00 38. , 92 C

ATOM 1313 NE2 HIS A 199 29. .725 5. .792 34. .324 1. .00 38. .92 N

ATOM 1314 N THR A 200 29. .619 9. .335 39. .967 1. .00 40. .42 N

ATOM 1315 CA THR A 200 29. .918 10. .121 41. .179 1. , 00 41. , 14 C

ATOM 1316 C THR A 200 29. .908 9. .283 42. .457 1. .00 41. .44 C

ATOM 1317 O THR A 200 30. .063 9. .825 43. .552 1. .00 39. .51 O

ATOM 1318 CB THR A 200 28. .915 11. .283 41. .433 1. .00 41. .27 C

ATOM 1319 OG1 THR A 200 27. .673 10. .760 41. .935 1. .00 39. .87 O

ATOM 1320 CG2 THR A 200 28. .679 12. .144 40. .196 1. .00 41. .33 C

ATOM 1321 N GLY A 201 29. .677 7. .983 42. .327 1. .00 42. .60 N

ATOM 1322 CA GLY A 201 29. .548 7. .116 43. .499 1. .00 44. .23 C

ATOM 1323 C GLY A 201 28. .287 7. .365 44. .318 1. .00 45. .12 C

ATOM 1324 O GLY A 201 28. .023 6. .654 45. .288 1. .00 47. .32 O

ATOM 1325 N GLU A 202 27. .516 8. .384 43. .934 1. .00 44. .55 N

ATOM 1326 CA GLU A 202 26. .226 8. .677 44. .554 1. .00 43. .02 C

ATOM 1327 C GLU A 202 25. .065 8. ,214 43. , 664 1. , 00 39. ,71 C ATOM 1328 O GLU A 202 25..259 7..912 42..495 1..00 36..99 O

ATOM 1329 CB GLU A 202 26. .115 10. .176 44. .876 1. .00 47. .01 C

ATOM 1330 CG GLU A 202 27. .086 10. .653 45. .953 1. .00 52. .50 C

ATOM 1331 CD GLU A 202 26. .690 10. .191 47. .347 1. .00 55. .82 C

ATOM 1332 OE1 GLU A 202 25. .863 10. .881 47. .979 1. .00 60. .52 O

ATOM 1333 OE2 GLU A 202 27. .193 9. .143 47. .816 1. .00 55. .46 O

ATOM 1334 N TRP A 203 23. .865 8. .152 44. .235 1. .00 39. .10 N

ATOM 1335 CA TRP A 203 22. .643 7. .797 43. .494 1. .00 37. .44 C

ATOM 1336 C TRP A 203 21. .960 8. .992 42. .891 1. .00 34. .81 C

ATOM 1337 O TRP A 203 21. .828 10. .015 43. .539 1. .00 35. .26 O

ATOM 1338 CB TRP A 203 21. .661 7. .080 44. .417 1. .00 36. .42 C

ATOM 1339 CG TRP A 203 22. .009 5. , 627 44. , 595 1. , 00 36. , 33 c

ATOM 1340 CD1 TRP A 203 22. .743 5. .044 45. .632 1. .00 34. .26 c

ATOM 1341 CD2 TRP A 203 21. .673 4. .517 43. .687 1. .00 35. .25 c

ATOM 1342 NE1 TRP A 203 22. .881 3. .693 45. .428 1. , 00 34. , 94 N

ATOM 1343 CE2 TRP A 203 22. .262 3. .308 44. .286 1. .00 34. .51 C

ATOM 1344 CE3 TRP A 203 20. .968 4. .408 42. .482 1. .00 33. .38 C

ATOM 1345 CZ2 TRP A 203 22. .133 2. .061 43. .697 1. .00 32. .78 C

ATOM 1346 CZ3 TRP A 203 20. .852 3. .144 41. .895 1. .00 33. .35 c

ATOM 1347 CH2 TRP A 203 21. .417 1. .998 42. .495 1. .00 34. .81 c

ATOM 1348 N SER A 204 21. .510 8. .868 41. .646 1. .00 33. .04 N

ATOM 1349 CA SER A 204 20. .674 9. .897 41. .020 1. .00 30. .74 C

ATOM 1350 C SER A 204 19. .650 9. .245 40. .069 1. .00 29. .63 C

ATOM 1351 O SER A 204 19. .454 8. .027 40. .089 1. .00 28. .94 O

ATOM 1352 CB SER A 204 21. .561 10. .918 40. .280 1. .00 31. .19 c

ATOM 1353 OG SER A 204 20. .830 12. .084 39. .918 1. .00 31. .76 0

ATOM 1354 N LYS A 205 19. .008 10. .043 39. .220 1. .00 27. .73 N

ATOM 1355 CA LYS A 205 18. .004 9. .499 38. .291 1. .00 26. .50 C

ATOM 1356 C LYS A 205 17. .869 10. .343 37. .028 1. .00 24. .29 C

ATOM 1357 O LYS A 205 18. .175 11. .543 37. .034 1. .00 24. .30 O

ATOM 1358 CB LYS A 205 16. .637 9. .375 38. .986 1. .00 26. .09 c

ATOM 1359 CG LYS A 205 15. .953 10. .714 39. .209 1. .00 27. .72 c

ATOM 1360 CD LYS A 205 14. .651 10. .618 39. .998 1. .00 28. .03 c

ATOM 1361 CE LYS A 205 14. .209 12. .008 40. .416 1. .00 27. .76 c

ATOM 1362 NZ LYS A 205 12. .746 12. .082 40. .698 1. .00 28. .37 N

ATOM 1363 N THR A 206 17. .404 9. .692 35. .963 1. .00 22. .43 N

ATOM 1364 CA THR A 206 17. .102 10. .319 34. .690 1. .00 21. .49 C

ATOM 1365 C THR A 206 15. .726 9. .832 34. .284 1. .00 21. .38 C

ATOM 1366 O THR A 206 15. .420 8. .651 34. .427 1. .00 21. .92 O

ATOM 1367 CB THR A 206 18. .127 9. .937 33. .604 1. .00 20. .65 C

ATOM 1368 OG1 THR A 206 19. .390 10. .521 33. .922 1. .00 20. .29 O

ATOM 1369 CG2 THR A 206 17. .685 10. .432 32. .216 1. .00 20. .09 C

ATOM 1370 N VAL A 207 14. .895 10. , 744 33. , 788 1. , 00 20. , 42 N

ATOM 1371 CA VAL A 207 13. .521 10. .404 33. .473 1. .00 19. .69 C

ATOM 1372 C VAL A 207 13. .302 10. .500 31. .971 1. .00 19. .94 C

ATOM 1373 O VAL A 207 13. .621 11. .517 31. .335 1. , 00 19. , 25 O

ATOM 1374 CB VAL A 207 12. .525 11. .320 34. .205 1. .00 19. .87 C

ATOM 1375 CGI VAL A 207 11. .095 10. .943 33. .821 1. .00 19. .23 c

ATOM 1376 CG2 VAL A 207 12. .718 11. .234 35. .726 1. .00 19. .15 c

ATOM 1377 N PHE A 208 12. .775 9. .416 31. .423 1. .00 19. .53 N

ATOM 1378 CA PHE A 208 12. .505 9. .276 30. .010 1. .00 20. .85 C

ATOM 1379 C PHE A 208 11. .007 9. .274 29. .736 1. .00 20. .54 C

ATOM 1380 O PHE A 208 10. .230 8. .767 30. .548 1. .00 21. .70 O

ATOM 1381 CB PHE A 208 13. .060 7. .935 29. .541 1. .00 20. .76 c

ATOM 1382 CG PHE A 208 14. .534 7. .814 29. .695 1. .00 22. .10 c

ATOM 1383 CD1 PHE A 208 15. .083 7. .439 30. .907 1. .00 21. .44 c

ATOM 1384 CD2 PHE A 208 15. .374 8. .073 28. .620 1. .00 21. .98 c

ATOM 1385 CE1 PHE A 208 16. .443 7. .323 31. .050 1. .00 22. .89 c

ATOM 1386 CE2 PHE A 208 16. .739 7. .957 28. .759 1. .00 23. .39 c

ATOM 1387 CZ PHE A 208 17. .278 7. .586 29. .977 1. .00 22. .33 c

ATOM 1388 N GLU A 209 10. .613 9. .802 28. .584 1. .00 19. .32 N ATOM 1389 CA GLU A 209 9..219 9..778 28..201 1..00 20..82 C

ATOM 1390 C GLU A 209 9. .092 9. .407 26. .738 1. .00 20. .07 C

ATOM 1391 O GLU A 209 9. .827 9. .922 25. .907 1. .00 21. .32 O

ATOM 1392 CB GLU A 209 8. .570 11. .144 28. .441 1. .00 22. .04 C

ATOM 1393 CG GLU A 209 7. .093 11. .172 28. .096 1. .00 24. .55 C

ATOM 1394 CD GLU A 209 6. .509 12. .567 28. .138 1. .00 28. .41 C

ATOM 1395 OE1 GLU A 209 6. .961 13. ,466 27. , 381 1. , 00 31. , 45 O

ATOM 1396 OE2 GLU A 209 5. .577 12. .764 28. .932 1. .00 31. .88 O

ATOM 1397 N TYR A 210 8. .187 8. .494 26. .431 1. .00 20. .06 N

ATOM 1398 CA TYR A 210 7. .741 8. .323 25. .045 1. , 00 20. , 67 C

ATOM 1399 C TYR A 210 6. .288 8. .734 24. .882 1. .00 20. .95 C

ATOM 1400 O TYR A 210 5. .417 8. .318 25. .653 1. .00 20. .63 O

ATOM 1401 CB TYR A 210 7. .969 6. .902 24. .505 1. .00 21. .14 C

ATOM 1402 CG TYR A 210 7. .690 6. .798 23. .014 1. .00 22. .82 c

ATOM 1403 CD1 TYR A 210 8. .550 7. .386 22. .071 1. .00 22. .22 c

ATOM 1404 CD2 TYR A 210 6. .551 6. .148 22. .546 1. .00 22. .47 c

ATOM 1405 CE1 TYR A 210 8. .292 7. .299 20. .710 1. .00 21. .92 c

ATOM 1406 CE2 TYR A 210 6. .288 6. .059 21. .198 1. .00 22. .67 c

ATOM 1407 CZ TYR A 210 7. .155 6. .637 20. .285 1. .00 23. .05 c

ATOM 1408 OH TYR A 210 6. .858 6. .547 18. .947 1. .00 23. .44 0

ATOM 1409 N ARG A 211 6. .042 9. .540 23. .858 1. .00 21. .37 N

ATOM 1410 CA ARG A 211 4. .737 10. .105 23. .600 1. .00 23. .98 C

ATOM 1411 C ARG A 211 4. .385 9. .867 22. .128 1. .00 24. .48 c

ATOM 1412 O ARG A 211 5. .215 10. .054 21. .244 1. .00 24. .73 0

ATOM 1413 CB ARG A 211 4. .788 11. .598 23. .958 1. .00 25. .88 c

ATOM 1414 CG ARG A 211 3. .463 12. .312 24. .008 1. .00 29. .67 c

ATOM 1415 CD ARG A 211 3. .646 13. .739 24. .521 1. .00 31. .11 c

ATOM 1416 NE ARG A 211 3. .848 13. .750 25. .963 1. .00 33. .02 N

ATOM 1417 CZ ARG A 211 2. .856 13. .733 26. .852 1. .00 35. .99 C

ATOM 1418 NH1 ARG A 211 1. .588 13. .716 26. .447 1. .00 38. .83 N

ATOM 1419 NH2 ARG A 211 3. .123 13. .739 28. .147 1. .00 33. .47 N

ATOM 1420 N THR A 212 3. .174 9. .406 21. .849 1. .00 24. .60 N

ATOM 1421 CA THR A 212 2. .845 9. .031 20. .467 1. .00 24. .91 C

ATOM 1422 C THR A 212 1. .353 9. , 133 20. , 148 1. , 00 25. , 66 C

ATOM 1423 O THR A 212 0. .499 8. .917 21. .022 1. .00 25. .35 O

ATOM 1424 CB THR A 212 3. .300 7. .585 20. .146 1. .00 25. .01 C

ATOM 1425 OG1 THR A 212 3. .046 7. .295 18. .769 1. , 00 24. ,29 O

ATOM 1426 CG2 THR A 212 2. .534 6. .542 20. .995 1. .00 24. .15 C

ATOM 1427 N ARG A 213 1. .047 9. .415 18. .888 1. .00 26. .61 N

ATOM 1428 CA ARG A 213 -0. .322 9. .317 18. .388 1. .00 28. .29 C

ATOM 1429 C ARG A 213 -0. .631 7. .909 17. .860 1. .00 28. .03 C

ATOM 1430 O ARG A 213 -1. .748 7. .634 17. .458 1. .00 30. .58 O

ATOM 1431 CB ARG A 213 -0. .572 10. .397 17. .326 1. .00 33. .29 C

ATOM 1432 CG ARG A 213 -0. .558 11. .806 17. .930 1. .00 39. .79 c

ATOM 1433 CD ARG A 213 -0. .799 12. .933 16. .930 1. .00 44. .72 c

ATOM 1434 NE ARG A 213 -1. .982 12. .723 16. .090 1. .00 50. .21 N

ATOM 1435 CZ ARG A 213 -3. .244 12. .919 16. .476 1. .00 55. .47 C

ATOM 1436 NH1 ARG A 213 -3. .523 13. .335 17. .710 1. .00 54. .38 N

ATOM 1437 NH2 ARG A 213 -4. .237 12. .693 15. .621 1. .00 56. .14 N

ATOM 1438 N LYS A 214 0. .360 7. .021 17. .880 1. .00 26. .94 N

ATOM 1439 CA LYS A 214 0. .205 5. .640 17. .416 1. .00 27. .45 C

ATOM 1440 C LYS A 214 0. .357 4. .717 18. .599 1. .00 24. .60 C

ATOM 1441 O LYS A 214 1. .417 4. .122 18. .807 1. .00 22. .80 O

ATOM 1442 CB LYS A 214 1. .248 5. .307 16. .335 1. .00 30. .90 C

ATOM 1443 CG LYS A 214 0. .898 5. .882 14. .966 1. .00 36. .72 C

ATOM 1444 CD LYS A 214 -0. .123 4. .993 14. .246 1. .00 42. .16 C

ATOM 1445 CE LYS A 214 -1. .355 5. .768 13. .777 1. .00 40. .96 C

ATOM 1446 NZ LYS A 214 -0. .995 6. .823 12. .790 1. .00 43. .70 N

ATOM 1447 N ALA A 215 -0. .722 4. .613 19. .367 1. .00 21. .93 N

ATOM 1448 CA ALA A 215 -0. .696 4. .036 20. .703 1. .00 21. .78 C

ATOM 1449 C ALA A 215 -0. .362 2. .543 20. .762 1. .00 22. .05 C ATOM 1450 O ALA A 215 -0..020 2 ,.028 21..842 1 ,.00 21 ,.28 O

ATOM 1451 CB ALA A 215 -2. .002 4 , .349 21. .438 1 , .00 22 , .08 C

ATOM 1452 N VAL A 216 -0. .416 1 , .857 19. .615 1 , .00 21 , .27 N

ATOM 1453 CA VAL A 216 0. .036 0 , .455 19. .540 1 , .00 22 , .24 C

ATOM 1454 C VAL A 216 1. .520 0 , .301 19. .917 1 , .00 22 , .27 C

ATOM 1455 O VAL A 216 1. .958 -0. .776 20. , 332 1. .00 21. .68 O

ATOM 1456 CB VAL A 216 -0. .285 -0. .242 18. ,169 1. .00 22. .83 c

ATOM 1457 CGI VAL A 216 -1. .791 -0. .367 17. , 982 1. .00 22. .34 c

ATOM 1458 CG2 VAL A 216 0. .318 0 , .515 16. .993 1 , .00 22 , .81 c

ATOM 1459 N ARG A 217 2. .282 1 , .382 19. .803 1. .00 22. .57 N

ATOM 1460 CA ARG A 217 3. .701 1 , .340 20. .155 1 , .00 23, .53 C

ATOM 1461 C ARG A 217 3. .948 1 , .183 21. .652 1 , .00 22 , .51 C

ATOM 1462 O ARG A 217 5. .004 0 , .746 22. .072 1 , .00 24 , .04 O

ATOM 1463 CB ARG A 217 4. .403 2 , .591 19. .633 1 , .00 24 , .57 c

ATOM 1464 CG ARG A 217 4. .556 2 , .603 18. .126 1 , .00 25, .21 c

ATOM 1465 CD ARG A 217 5. .026 3, .976 17. .644 1 , .00 27 , .57 c

ATOM 1466 NE ARG A 217 4. .787 4 , .111 16. .207 1 , .00 28 , .43 N

ATOM 1467 CZ ARG A 217 4. .954 5, .214 15. .487 1 , .00 28 , .85 C

ATOM 1468 NH1 ARG A 217 5. .359 6, .352 16. .033 1 , .00 30 , .76 N

ATOM 1469 NH2 ARG A 217 4. .696 5, .172 14. .201 1 , .00 29, .06 N

ATOM 1470 N LEU A 218 2. .969 1 , .529 22. .465 1 , .00 22 , .65 N

ATOM 1471 CA LEU A 218 3. .119 1 , .399 23. .920 1 , .00 21 , .57 C

ATOM 1472 C LEU A 218 2. .244 0 , .246 24. .399 1 , .00 20 , .91 C

ATOM 1473 O LEU A 218 1. .349 -0. .162 23. , 674 1. .00 21. .07 O

ATOM 1474 CB LEU A 218 2. .717 2 , .697 24. .627 1 , .00 19, .42 C

ATOM 1475 CG LEU A 218 3. .679 3, .878 24. .478 1 , .00 20 , .69 C

ATOM 1476 CD1 LEU A 218 3. .057 5, .143 25. .079 1 , .00 19, .08 C

ATOM 1477 CD2 LEU A 218 5. .038 3, .589 25. .115 1 , .00 20 , .83 C

ATOM 1478 N PRO A 219 2. .459 -0. .243 25. , 639 1. .00 20. .58 N

ATOM 1479 CA PRO A 219 3. .421 0 , .204 26. .656 1 , .00 20 , .42 C

ATOM 1480 C PRO A 219 4. .851 -0. .256 26. ,410 1. .00 21. .42 C

ATOM 1481 O PRO A 219 5. .124 -1. .063 25. , 510 1. .00 21. .82 O

ATOM 1482 CB PRO A 219 2. .903 -0. .458 27. , 940 1. .00 20. .48 C

ATOM 1483 CG PRO A 219 2. .242 -1. .716 27. , 458 1. .00 20. .66 c

ATOM 1484 CD PRO A 219 1. .592 -1. .329 26. , 150 1. .00 21. .21 c

ATOM 1485 N ILE A 220 5. .739 0 , .271 27. .239 1 , .00 21 , .41 N

ATOM 1486 CA ILE A 220 7. .117 -0. .120 27. , 320 1. .00 22. .67 C

ATOM 1487 C ILE A 220 7. .214 -1. .460 28. , 053 1. .00 23. .80 C

ATOM 1488 O ILE A 220 6. .625 -1. .627 29. , 130 1. .00 23. .28 O

ATOM 1489 CB ILE A 220 7. .915 0 , .959 28. .083 1 , .00 23, .23 c

ATOM 1490 CGI ILE A 220 8. .042 2 , .216 27. .217 1 , .00 21 , .85 c

ATOM 1491 CG2 ILE A 220 9. .288 0 , .438 28. .502 1 , .00 22 , .95 c

ATOM 1492 CD1 ILE A 220 8. .531 3, .433 27. .970 1 , .00 23, .69 c

ATOM 1493 N VAL A 221 7. .948 -2. .410 27. , 474 1. .00 25. .16 N

ATOM 1494 CA VAL A 221 8. .033 -3. .760 28. ,061 1. .00 26. .86 C

ATOM 1495 C VAL A 221 9. .431 -4. .159 28. , 537 1. .00 26. .95 C

ATOM 1496 O VAL A 221 9. .572 -5. .119 29. , 282 1. .00 28. .75 0

ATOM 1497 CB VAL A 221 7. .446 -4. .882 27. , 144 1. .00 27. .43 c

ATOM 1498 CGI VAL A 221 5. .957 -4. .661 26. , 850 1. .00 25. .34 c

ATOM 1499 CG2 VAL A 221 8. .243 -5. .023 25. , 855 1. .00 25. .50 c

ATOM 1500 N ASP A 222 10. .457 -3. .429 28. ,119 1. .00 28. .06 N

ATOM 1501 CA ASP A 222 11. .824 -3. .721 28. , 582 1. .00 29. .19 C

ATOM 1502 C ASP A 222 12. .690 -2. .474 28. , 477 1. .00 27. .61 C

ATOM 1503 O ASP A 222 12. .328 -1. .513 27. ,799 1. .00 28. .16 0

ATOM 1504 CB ASP A 222 12. .450 -4. .881 27. , 773 1. .00 28. .59 c

ATOM 1505 CG ASP A 222 13. .473 -5. .710 28. , 587 1. .00 31. .79 c

ATOM 1506 OD1 ASP A 222 14. .038 -5. .244 29. , 617 1. .00 31. .15 0

ATOM 1507 OD2 ASP A 222 13. .718 -6. .867 28. ,190 1. .00 33. .34 0

ATOM 1508 N ILE A 223 13. .828 -2. .512 29. , 152 1. .00 26. .47 N

ATOM 1509 CA ILE A 223 14. .811 -1. .445 29. , 138 1. .00 27. .03 C

ATOM 1510 C ILE A 223 16. .207 -2. .047 28. , 919 1. .00 29. .80 C ATOM 1511 O ILE A 223 16..524 -3..095 29..506 1..00 28., 07 O

ATOM 1512 CB ILE A 223 14. .760 -0. .631 30. .455 1. .00 26. ,71 C

ATOM 1513 CGI ILE A 223 15. .690 0 , .581 30 , .386 1 , .00 25. .40 C

ATOM 1514 CG2 ILE A 223 15. .069 -1. .499 31. .682 1. .00 26. , 69 C

ATOM 1515 CD1 ILE A 223 15. .431 1 , .596 31 , .468 1 , .00 23. .36 C

ATOM 1516 N ALA A 224 17. .019 -1. .403 28. .068 1. .00 28. , 58 N

ATOM 1517 CA ALA A 224 18. .407 -1. .823 27. .852 1. .00 29. ,19 C

ATOM 1518 C ALA A 224 19. .425 -0. .737 28. .167 1. .00 28. , 66 C

ATOM 1519 O ALA A 224 19. .756 0 , .071 27 , .301 1 , .00 29. .40 O

ATOM 1520 CB ALA A 224 18. .621 -2. .338 26. .425 1. .00 31. , 20 C

ATOM 1521 N PRO A 225 19. .948 -0. .731 29. .401 1. .00 28. , 90 N

ATOM 1522 CA PRO A 225 21. .035 0 , .165 29, .709 1 , .00 30. .67 C

ATOM 1523 C PRO A 225 22. .253 -0. .182 28. .864 1. .00 32. , 95 C

ATOM 1524 O PRO A 225 22. .307 -1. .257 28. .267 1. .00 35. ,21 O

ATOM 1525 CB PRO A 225 21. .322 -0. .110 31. .190 1. .00 30. , 02 C

ATOM 1526 CG PRO A 225 20. .182 -0. .933 31. .696 1. .00 28. , 66 c

ATOM 1527 CD PRO A 225 19. .665 -1. .660 30. .507 1. .00 29. , 56 c

ATOM 1528 N TYR A 226 23. .211 0 , .732 28 , .821 1 , .00 34. .32 N

ATOM 1529 CA TYR A 226 24. .451 0 , .547 28 , .094 1 , .00 36. .51 C

ATOM 1530 C TYR A 226 25. .622 0 , .691 29, .067 1 , .00 36. .86 C

ATOM 1531 O TYR A 226 26. .515 -0. .156 29. .128 1. .00 36. , 03 O

ATOM 1532 CB TYR A 226 24. .544 1 , .589 26, .980 1 , .00 37. .86 c

ATOM 1533 CG TYR A 226 25. .799 1 , .525 26, .153 1 , .00 38. .08 c

ATOM 1534 CD1 TYR A 226 26. .953 2 , .186 26, .554 1 , .00 39. .52 c

ATOM 1535 CD2 TYR A 226 25. .828 0 , .814 24 , .960 1 , .00 41. .13 c

ATOM 1536 CE1 TYR A 226 28. .110 2 , .132 25, .795 1 , .00 42. .25 c

ATOM 1537 CE2 TYR A 226 26. .982 0 , .749 24 , .192 1 , .00 44. .17 c

ATOM 1538 CZ TYR A 226 28. .116 1 , .410 24 , .617 1 , .00 43. .55 c

ATOM 1539 OH TYR A 226 29. .252 1. .351 23. .854 1. .00 48. , 97 0

ATOM 1540 N ASP A 227 25. .611 1 , .756 29, .853 1 , .00 36. .59 N

ATOM 1541 CA ASP A 227 26. .723 1 , .995 30 , .753 1 , .00 36. .15 c

ATOM 1542 C ASP A 227 26. .554 1 , .221 32 , .049 1. .00 38. , 17 c

ATOM 1543 O ASP A 227 26. .266 1 , .788 33, .102 1 , .00 37. .08 0

ATOM 1544 CB ASP A 227 26. .911 3, .482 31 , .006 1 , .00 35. .10 c

ATOM 1545 CG ASP A 227 28. .193 3, .784 31 , .743 1 , .00 35. .66 c

ATOM 1546 OD1 ASP A 227 29. .226 3, .138 31 , .455 1 , .00 36. .91 0

ATOM 1547 OD2 ASP A 227 28. .165 4 , .678 32 , .608 1 , .00 35. .66 0

ATOM 1548 N ILE A 228 26. .739 -0. .091 31. .941 1. .00 39. , 74 N

ATOM 1549 CA ILE A 228 26. .695 -1. .016 33. .079 1. .00 41. , 47 C

ATOM 1550 C ILE A 228 27. .713 -2. .142 32. .858 1. .00 42. , 92 c

ATOM 1551 O ILE A 228 28. .293 -2. .245 31. .773 1. .00 39. , 78 0

ATOM 1552 CB ILE A 228 25. .295 -1. .643 33. .252 1. .00 39. ,41 c

ATOM 1553 CGI ILE A 228 24. .697 -1. .990 31. .883 1. .00 39. , 35 c

ATOM 1554 CG2 ILE A 228 24. .397 -0. .705 34. .035 1. .00 40. , 34 c

ATOM 1555 CD1 ILE A 228 23. .792 -3. .208 31. .870 1. .00 39. , 95 c

ATOM 1556 N GLY A 229 27. .840 -3. .009 33. .855 1. .00 45. , 30 N

ATOM 1557 CA GLY A 229 28. .777 -4. .118 33. .862 1. .00 51. , 38 C

ATOM 1558 C GLY A 229 30. .038 -3. .987 34. .703 1. .00 53. , 65 c

ATOM 1559 O GLY A 229 30. .756 -4. .948 34. .897 1. .00 56. , 53 0

ATOM 1560 N GLY A 230 30. .298 -2. .794 35. .194 1. .00 54. , 07 N

ATOM 1561 CA GLY A 230 31. .357 -2. .536 36. .135 1. .00 52. , 96 C

ATOM 1562 C GLY A 230 30. .909 -2. .820 37. .533 1. .00 55. , 39 C

ATOM 1563 O GLY A 230 29. .729 -2. .878 37. .781 1. .00 55. , 30 O

ATOM 1564 N PRO A 231 31. .867 -2. .986 38. .432 1. .00 54. , 10 N

ATOM 1565 CA PRO A 231 31. .657 -3. .367 39. .828 1. .00 53. , 25 C

ATOM 1566 C PRO A 231 30. .881 -2. .363 40. .620 1. .00 53. , 43 C

ATOM 1567 O PRO A 231 30. .097 -2. .706 41. .480 1. .00 53. , 04 O

ATOM 1568 CB PRO A 231 33. .077 -3. .391 40. .383 1. .00 53. ,76 C

ATOM 1569 CG PRO A 231 33. .923 -3. .668 39. .218 1. .00 54. ,16 c

ATOM 1570 CD PRO A 231 33. .284 -2. .973 38. .070 1. .00 54. , 03 c

ATOM 1571 N ASP A 232 31. .173 -1. .108 40. .343 1. .00 54. ,06 N ATOM 1572 CA ASP A 232 30..608 0 ,.032 41..024 1 ,.00 51 ,.89 C

ATOM 1573 C ASP A 232 29. .299 0 , .510 40. .393 1 , .00 47 , .54 C

ATOM 1574 O ASP A 232 28. .653 1 , .396 40. .901 1 , .00 43, .86 O

ATOM 1575 CB ASP A 232 31. .638 1 , .154 40. .962 1 , .00 56, .54 C

ATOM 1576 CG ASP A 232 32. .206 1 , .355 39. .556 1 , .00 60 , .63 C

ATOM 1577 OD1 ASP A 232 32. .357 0 , .373 38. .811 1 , .00 58 , .18 O

ATOM 1578 OD2 ASP A 232 32. .495 2 , .506 39. .184 1 , .00 64 , .78 O

ATOM 1579 N GLN A 233 28. .940 -0. .084 39. , 273 1. .00 42. .65 N

ATOM 1580 CA GLN A 233 27. .832 0 , .388 38. .435 1 , .00 42 , .15 C

ATOM 1581 C GLN A 233 26. .522 -0. .309 38. ,762 1. .00 43. .39 C

ATOM 1582 O GLN A 233 26. .345 -1. .492 38. , 425 1. .00 44. .00 O

ATOM 1583 CB GLN A 233 28. .157 0 , .146 36. .960 1 , .00 40 , .27 C

ATOM 1584 CG GLN A 233 29. .440 0 , .803 36. .482 1 , .00 39, .45 c

ATOM 1585 CD GLN A 233 29. .556 0 , .804 34. .970 1 , .00 40 , .46 c

ATOM 1586 OE1 GLN A 233 29. .823 -0. .229 34. , 358 1. .00 43. .88 0

ATOM 1587 NE2 GLN A 233 29. .346 1 , .968 34. .355 1 , .00 38 , .46 N

ATOM 1588 N GLU A 234 25. .610 0 , .435 39. .396 1 , .00 42 , .42 N

ATOM 1589 CA GLU A 234 24. .289 -0. .065 39. , 825 1. .00 40. .82 C

ATOM 1590 C GLU A 234 23. .104 0 , .729 39. .219 1 , .00 40 , .19 C

ATOM 1591 O GLU A 234 23. .226 1. .932 38. , 926 1. .00 36. .99 O

ATOM 1592 CB GLU A 234 24. .175 -0. .021 41. , 360 1. .00 42. .42 C

ATOM 1593 CG GLU A 234 25. .192 -0. .858 42. , 141 1. .00 45. .40 C

ATOM 1594 CD GLU A 234 24. .858 -0. .961 43. , 627 1. .00 46. .15 C

ATOM 1595 OE1 GLU A 234 23. .849 -1. .609 43. , 967 1. .00 49. .44 O

ATOM 1596 OE2 GLU A 234 25. .601 -0. .402 44. ,465 1. .00 47. .17 0

ATOM 1597 N PHE A 235 21. .957 0 , .067 39. .049 1 , .00 37 , .18 N

ATOM 1598 CA PHE A 235 20. .751 0 , .760 38. .607 1 , .00 37 , .03 C

ATOM 1599 C PHE A 235 19. .451 0 , .198 39. .160 1 , .00 36, .98 C

ATOM 1600 O PHE A 235 19. .383 -0. .955 39. , 596 1. .00 36. .59 O

ATOM 1601 CB PHE A 235 20. .679 0 , .884 37. .076 1 , .00 37 , .25 C

ATOM 1602 CG PHE A 235 20. .283 -0. .386 36. , 372 1. .00 37. .91 c

ATOM 1603 CD1 PHE A 235 18. .938 -0. .700 36. ,160 1. .00 36. .27 c

ATOM 1604 CD2 PHE A 235 21. .249 -1. .264 35. , 903 1. .00 37. .77 c

ATOM 1605 CE1 PHE A 235 18. .575 -1. .872 35. , 509 1. .00 37. .42 c

ATOM 1606 CE2 PHE A 235 20. .888 -2. .436 35. , 245 1. .00 36. .75 c

ATOM 1607 CZ PHE A 235 19. .554 -2. .747 35. , 056 1. .00 36. .03 c

ATOM 1608 N GLY A 236 18. .436 1 , .060 39. .152 1 , .00 36, .40 N

ATOM 1609 CA GLY A 236 17. .059 0 , .720 39. .489 1 , .00 34 , .74 C

ATOM 1610 C GLY A 236 16. .152 1 , .365 38. .453 1 , .00 31 , .48 c

ATOM 1611 O GLY A 236 16. .600 2 , .219 37. .698 1 , .00 29, .57 0

ATOM 1612 N VAL A 237 14. .885 0 , .946 38. .417 1 , .00 32 , .20 N

ATOM 1613 CA VAL A 237 13. .892 1 , .440 37. .448 1 , .00 30 , .34 C

ATOM 1614 C VAL A 237 12. .530 1 , .627 38. .112 1 , .00 30 , .93 C

ATOM 1615 O VAL A 237 12. .044 0 , .740 38. .819 1 , .00 29, .92 O

ATOM 1616 CB VAL A 237 13. .732 0 , .487 36. .240 1 , .00 30 , .44 c

ATOM 1617 CGI VAL A 237 12. .848 1 , .109 35. .159 1 , .00 30 , .10 c

ATOM 1618 CG2 VAL A 237 15. .087 0 , .109 35. .650 1 , .00 29, .80 c

ATOM 1619 N ASP A 238 11. .938 2 , .803 37. .911 1 , .00 29, .64 N

ATOM 1620 CA ASP A 238 10. .535 3, .042 38. .230 1 , .00 28 , .83 C

ATOM 1621 C ASP A 238 9. .786 3, .107 36. .918 1 , .00 27 , .09 C

ATOM 1622 O ASP A 238 10. .050 3, .987 36. .099 1 , .00 26, .54 O

ATOM 1623 CB ASP A 238 10. .340 4 , .364 38. .985 1 , .00 31 , .82 c

ATOM 1624 CG ASP A 238 10. .673 4 , .256 40. .453 1 , .00 35, .53 c

ATOM 1625 OD1 ASP A 238 10. .307 3. .233 41. , 076 1. .00 42. .70 0

ATOM 1626 OD2 ASP A 238 11. .269 5, .209 40. .997 1 , .00 38 , .23 0

ATOM 1627 N VAL A 239 8. .876 2 , .160 36. .714 1 , .00 24 , .83 N

ATOM 1628 CA VAL A 239 8. .100 2 , .081 35. .495 1. .00 23. .13 C

ATOM 1629 C VAL A 239 6. .819 2 , .845 35. .692 1 , .00 21 , .75 C

ATOM 1630 O VAL A 239 5. .947 2 , .431 36. .459 1 , .00 20 , .13 0

ATOM 1631 CB VAL A 239 7. .753 0 , .630 35. .115 1 , .00 24 , .31 c

ATOM 1632 CGI VAL A 239 6. .970 0 , .596 33. .802 1 , .00 24 , .31 c ATOM 1633 CG2 VAL A 239 9..027 -0.,195 34., 992 1..00 26.,01 C

ATOM 1634 N GLY A 240 6. .700 3. .959 34. .980 1 , .00 20. .78 N

ATOM 1635 CA GLY A 240 5. .499 4. .765 35. .063 1 , .00 19. .45 C

ATOM 1636 C GLY A 240 4. .357 4. .041 34. .376 1 , .00 19. .03 C

ATOM 1637 O GLY A 240 4. .585 3. .088 33. .607 1 , .00 17. .85 O

ATOM 1638 N PRO A 241 3. .117 4. .451 34. .696 1 , .00 18. .65 N

ATOM 1639 CA PRO A 241 1. .938 3. .871 34. .073 1 , .00 18. .41 C

ATOM 1640 C PRO A 241 1. .832 4. .254 32. .619 1 , .00 17. .54 C

ATOM 1641 O PRO A 241 2. .287 5. .313 32. .225 1 , .00 18. .43 O

ATOM 1642 CB PRO A 241 0. .765 4. .499 34. .856 1 , .00 18. .17 C

ATOM 1643 CG PRO A 241 1. .320 5. .719 35. .504 1 , .00 17. .67 c

ATOM 1644 CD PRO A 241 2. .760 5. .372 35. .799 1 , .00 18. .56 c

ATOM 1645 N VAL A 242 1. .234 3. .390 31. .819 1 , .00 17. .29 N

ATOM 1646 CA VAL A 242 0. .983 3. .752 30. .448 1 , .00 17. .11 C

ATOM 1647 C VAL A 242 -0. .330 4. , 530 30. , 459 1. .00 17. , 28 C

ATOM 1648 O VAL A 242 -1. .334 4. .087 31. .041 1 , .00 17. .63 O

ATOM 1649 CB VAL A 242 1. .017 2. .515 29. .517 1 , .00 17. .35 c

ATOM 1650 CGI VAL A 242 0. .140 1. .370 30. .058 1. .00 16. , 96 c

ATOM 1651 CG2 VAL A 242 0. .633 2. .904 28. .093 1 , .00 16. .86 c

ATOM 1652 N CYS A 243 -0. .315 5. .710 29. .858 1 , .00 16. .79 N

ATOM 1653 CA CYS A 243 -1. .469 6. .570 29. .929 1 , .00 17. .34 C

ATOM 1654 C CYS A 243 -2. .061 6. .733 28. .553 1 , .00 18. .13 C

ATOM 1655 O CYS A 243 -1. .373 7. .176 27. .629 1 , .00 18. .63 O

ATOM 1656 CB CYS A 243 -1. .093 7. .938 30. .545 1 , .00 17. .27 c

ATOM 1657 SG CYS A 243 -0. .721 7. .866 32. .312 1 , .00 15. .27 s

ATOM 1658 N PHE A 244 -3. .327 6. .349 28. .411 1 , .00 17. .97 N

ATOM 1659 CA PHE A 244 -4. .032 6. .447 27. .124 1 , .00 19. .12 C

ATOM 1660 C PHE A 244 -5. .056 7. .570 27. .152 1 , .00 20. .89 C

ATOM 1661 O PHE A 244 -5. .741 7. .760 28. .165 1 , .00 22. .36 O

ATOM 1662 CB PHE A 244 -4. .772 5. .155 26. .832 1 , .00 17. .53 c

ATOM 1663 CG PHE A 244 -3. .878 3. .968 26. .688 1 , .00 17. .77 c

ATOM 1664 CD1 PHE A 244 -3. .286 3. .671 25. .453 1 , .00 17. .45 c

ATOM 1665 CD2 PHE A 244 -3. .641 3. .126 27. .767 1 , .00 17. .13 c

ATOM 1666 CE1 PHE A 244 -2. .451 2. .565 25. .311 1 , .00 17. .98 c

ATOM 1667 CE2 PHE A 244 -2. .826 2. .015 27. .624 1 , .00 17. .41 c

ATOM 1668 CZ PHE A 244 -2. .222 1. .733 26. .399 1 , .00 17. .55 c

ATOM 1669 N LEU A 245 -5. .168 8. .294 26. .060 1 , .00 22. .48 N

ATOM 1670 CA LEU A 245 -6. .227 9. .243 25. .882 1 , .00 25. .37 C

ATOM 1671 C LEU A 245 -7. .232 8. .781 24. .826 1 , .00 29. .94 c

ATOM 1672 O LEU A 245 -8. .284 8. .272 25. .172 1 , .00 31. .71 0

ATOM 1673 CB LEU A 245 -5. .678 10. .601 25. .513 1 , .00 26. .88 c

ATOM 1674 CG LEU A 245 -6. .705 11. .720 25. .436 1 , .00 27. .98 c

ATOM 1675 CD1 LEU A 245 -7. .613 11. , 755 26. , 648 1. .00 27. , 61 c

ATOM 1676 CD2 LEU A 245 -6. .016 13. .043 25. .264 1 , .00 27. .49 c

ATOM 1677 OXT LEU A 245 -7. .197 8. .963 23. .670 1 , .00 30. .35 0

TER 1678 LEU A 245

ATOM 1679 N ILE B 28 -28. .311 -9. , 047 33. , 849 1. .00 44. , 92 N

ATOM 1680 CA ILE B 28 -27. .826 -10. , 289 33. , 259 1. .00 45. , 60 C

ATOM 1681 C ILE B 28 -26. .934 -10. ,014 32. , 053 1. .00 44. , 57 c

ATOM 1682 O ILE B 28 -26. .973 -8. , 929 31. , 474 1. .00 42. , 83 0

ATOM 1683 CB ILE B 28 -28. .989 -11. , 201 32. , 828 1. .00 45. , 34 c

ATOM 1684 N SER B 29 -26. .134 -11. , 002 31. , 705 1. .00 45. , 63 N

ATOM 1685 CA SER B 29 -25. .112 -10. , 903 30. , 699 1. .00 45. ,49 C

ATOM 1686 C SER B 29 -25. .480 -11. , 903 29. , 617 1. .00 40. ,71 C

ATOM 1687 O SER B 29 -25. .912 -12. , 989 29. , 917 1. .00 43. , 66 O

ATOM 1688 CB SER B 29 -23. .761 -11. , 242 31. , 321 1. .00 48. ,16 c

ATOM 1689 OG SER B 29 -22. .690 -10. , 572 30. , 695 1. .00 48. , 72 0

ATOM 1690 N PRO B 30 -25. .316 -11. , 535 28. , 361 1. .00 36. , 23 N

ATOM 1691 CA PRO B 30 -25. .917 -12. , 289 27. ,267 1. .00 33. , 25 C

ATOM 1692 C PRO B 30 -25. .452 -13. ,719 27. , 256 1. .00 31. , 10 C

ATOM 1693 O PRO B 30 -24. .316 -13. , 962 27. , 555 1. .00 32. , 33 O ATOM 1694 CB PRO B 30 -25..411 -11..572 26..015 1..00 33..25 C

ATOM 1695 CG PRO B 30 -24. .416 -10. .573 26. .460 1. .00 33. .49 C

ATOM 1696 CD PRO B 30 -24. .633 -10. .321 27. .900 1. .00 34. .81 C

ATOM 1697 N ASP B 31 -26. .319 -14. .654 26. .926 1. .00 27. .41 N

ATOM 1698 CA ASP B 31 -25. .942 -16. .059 27. .072 1. .00 28. .37 C

ATOM 1699 C ASP B 31 -25. .523 -16. .798 25. .788 1. .00 26. .46 C

ATOM 1700 O ASP B 31 -25. .382 -18. .014 25. .801 1. .00 25. .34 O

ATOM 1701 CB ASP B 31 -27. .045 -16. .839 27. .789 1. .00 31. .39 C

ATOM 1702 CG ASP B 31 -28. .354 -16. .827 27. .037 1. .00 33. .78 C

ATOM 1703 OD1 ASP B 31 -28. .441 -16. .269 25. .917 1. .00 33. .50 0

ATOM 1704 OD2 ASP B 31 -29. .321 -17. .381 27. .590 1. .00 40. .93 0

ATOM 1705 N GLY B 32 -25. .314 -16. .069 24. .697 1. .00 23. .78 N

ATOM 1706 CA GLY B 32 -24. .830 -16. .679 23. .471 1. .00 22. .72 C

ATOM 1707 C GLY B 32 -25. .897 -17. .319 22. .605 1. .00 22. .46 C

ATOM 1708 O GLY B 32 -25. .578 -18. .093 21. .718 1. .00 20. .61 O

ATOM 1709 N SER B 33 -27. .169 -17. .029 22. .877 1. .00 23. .21 N

ATOM 1710 CA SER B 33 -28. .264 -17. .490 22. .006 1. .00 23. .47 C

ATOM 1711 C SER B 33 -28. .404 -16. .482 20. .869 1. .00 23. .97 C

ATOM 1712 O SER B 33 -27. .864 -15. .374 20. .957 1. .00 23. .31 O

ATOM 1713 CB SER B 33 -29. .556 -17. .506 22. .806 1. .00 23. .27 C

ATOM 1714 OG SER B 33 -29. .852 -16. .174 23. .194 1. .00 23. .64 0

ATOM 1715 N ARG B 34 -29. .132 -16. .836 19. .812 1. .00 24. .22 N

ATOM 1716 CA ARG B 34 -29. .372 -15. .891 18. .724 1. .00 24. .50 C

ATOM 1717 C ARG B 34 -30. .048 -14. .604 19. .199 1. .00 24. .54 C

ATOM 1718 O ARG B 34 -29. .700 -13. .531 18. .757 1. .00 24. .56 O

ATOM 1719 CB ARG B 34 -30. .176 -16. .529 17. .588 1. .00 25. .74 C

ATOM 1720 CG ARG B 34 -30. .222 -15. .656 16. .338 1. .00 26. .65 c

ATOM 1721 CD ARG B 34 -30. .664 -16. .422 15. .098 1. .00 27. .17 c

ATOM 1722 NE ARG B 34 -30. .501 -15. .590 13. .910 1. .00 28. .74 N

ATOM 1723 CZ ARG B 34 -30. .724 -15. .989 12. .658 1. .00 30. .50 C

ATOM 1724 NH1 ARG B 34 -31. .109 -17. .237 12. .394 1. .00 31. .06 N

ATOM 1725 NH2 ARG B 34 -30. .542 -15. .128 11. .669 1. .00 31. .20 N

ATOM 1726 N LYS B 35 -30. .998 -14. .709 20. .118 1. .00 26. .26 N

ATOM 1727 CA LYS B 35 -31. .631 -13. .520 20. .679 1. .00 27. .87 C

ATOM 1728 C LYS B 35 -30. .693 -12. .637 21. .530 1. .00 26. .22 C

ATOM 1729 O LYS B 35 -30. .849 -11. .415 21. .567 1. .00 25. .52 O

ATOM 1730 CB LYS B 35 -32. .884 -13. .888 21. .490 1. .00 32. .50 C

ATOM 1731 CG LYS B 35 -33. .665 -12. .647 21. .915 1. .00 36. .42 C

ATOM 1732 CD LYS B 35 -35. .047 -12. .929 22. .473 1. .00 42. .56 C

ATOM 1733 CE LYS B 35 -35. .818 -11. .613 22. .523 1. .00 45. .91 C

ATOM 1734 NZ LYS B 35 -37. .133 -11. .728 23. .216 1. .00 51. .11 N

ATOM 1735 N ASN B 36 -29. .733 -13. .270 22. .207 1. .00 24. .68 N

ATOM 1736 CA ASN B 36 -28. .824 -12. .591 23. .122 1. .00 23. .87 C

ATOM 1737 C ASN B 36 -27. .357 -13. .007 22. .873 1. .00 21. .74 C

ATOM 1738 O ASN B 36 -26. .756 -13. .707 23. .700 1. .00 19. .81 O

ATOM 1739 CB ASN B 36 -29. .216 -12. .906 24. .578 1. .00 26. .50 C

ATOM 1740 CG ASN B 36 -30. .611 -12. .421 24. .935 1. .00 27. .98 C

ATOM 1741 OD1 ASN B 36 -30. .915 -11. .244 24. .820 1. .00 30. .58 O

ATOM 1742 ND2 ASN B 36 -31. .457 -13. .332 25. .390 1. .00 30. .11 N

ATOM 1743 N PRO B 37 -26. .778 -12. .601 21. .725 1. .00 20. .33 N

ATOM 1744 CA PRO B 37 -25. .417 -13. .053 21. .452 1. .00 19. .76 C

ATOM 1745 C PRO B 37 -24. .404 -12. .429 22. .410 1. .00 19. .69 C

ATOM 1746 O PRO B 37 -24. .568 -11. .284 22. .807 1. .00 19. .70 O

ATOM 1747 CB PRO B 37 -25. .166 -12. .577 20. .009 1. .00 19. .96 C

ATOM 1748 CG PRO B 37 -26. .095 -11. .422 19. .821 1. .00 20. .73 C

ATOM 1749 CD PRO B 37 -27. .316 -11. .766 20. .635 1. .00 21. .01 C

ATOM 1750 N ALA B 38 -23. .365 -13. .176 22. .774 1. .00 19. .23 N

ATOM 1751 CA ALA B 38 -22. .243 -12. .607 23. .527 1. .00 19. .17 C

ATOM 1752 C ALA B 38 -21. .273 -11. .879 22. .584 1. .00 19. .41 C

ATOM 1753 O ALA B 38 -21. .384 -12. .009 21. .376 1. .00 19. .54 O

ATOM 1754 CB ALA B 38 -21. .537 -13. .689 24. .321 1. .00 18. .58 C ATOM 1755 N ARG B 39 -20..350 -11..090 23..131 1..00 19..18 N

ATOM 1756 CA ARG B 39 -19. .389 -10. .365 22. .321 1. .00 18. .98 C

ATOM 1757 C ARG B 39 -18. .476 -11. .349 21. .564 1. .00 19. .54 C

ATOM 1758 O ARG B 39 -18. .222 -11. .186 20. .367 1. .00 17. .99 O

ATOM 1759 CB ARG B 39 -18. .553 -9. .438 23. .213 1. .00 19. .55 C

ATOM 1760 CG ARG B 39 -17. .522 -8. .591 22. .461 1. .00 19. .34 c

ATOM 1761 CD ARG B 39 -16. .788 -7. .643 23. .405 1. .00 20. .72 c

ATOM 1762 NE ARG B 39 -15. .799 -8. .342 24. .234 1. .00 19. .70 N

ATOM 1763 CZ ARG B 39 -14. .563 -8. .661 23. .843 1. .00 20. .74 C

ATOM 1764 NH1 ARG B 39 -14. .104 -8. .342 22. .623 1. .00 20. .02 N

ATOM 1765 NH2 ARG B 39 -13. .762 -9. .299 24. .680 1. .00 20. .22 N

ATOM 1766 N ASN B 40 -17. .945 -12. .327 22. .304 1. .00 18. .63 N

ATOM 1767 CA ASN B 40 -17. .222 -13. .472 21. .758 1. .00 18. .73 C

ATOM 1768 C ASN B 40 -17. .294 -14. .634 22. .738 1. .00 19. .17 C

ATOM 1769 O ASN B 40 -17. .979 -14. .520 23. .772 1. .00 18. .72 O

ATOM 1770 CB ASN B 40 -15. .777 -13. .129 21. .400 1. .00 19. .57 C

ATOM 1771 CG ASN B 40 -14. .981 -12. .586 22. .568 1. .00 19. .56 C

ATOM 1772 OD1 ASN B 40 -15. .277 -12. .849 23. .722 1. .00 20. .12 O

ATOM 1773 ND2 ASN B 40 -13. .945 -11. .828 22. .254 1. .00 20. .45 N

ATOM 1774 N CYS B 41 -16. .599 -15. .733 22. .431 1. .00 18. .44 N

ATOM 1775 CA CYS B 41 -16. .613 -16. .917 23. .294 1. .00 18. .05 C

ATOM 1776 C CYS B 41 -15. .820 -16. .736 24. .599 1. .00 18. .81 C

ATOM 1777 O CYS B 41 -16. .157 -17. .351 25. .610 1. .00 19. .28 O

ATOM 1778 CB CYS B 41 -16. .090 -18. .156 22. .535 1. .00 17. .39 C

ATOM 1779 SG CYS B 41 -17. .108 -18. .561 21. .097 1. .00 17. .19 S

ATOM 1780 N ARG B 42 -14. .765 -15. .921 24. .582 1. .00 19. .02 N

ATOM 1781 CA ARG B 42 -14. .039 -15. .618 25. .815 1. .00 19. .14 C

ATOM 1782 C ARG B 42 -14. .921 -14. .919 26. .832 1. .00 20. .33 C

ATOM 1783 O ARG B 42 -14. .889 -15. .251 28. .015 1. .00 21. .04 O

ATOM 1784 CB ARG B 42 -12. .791 -14. .777 25. .558 1. .00 19. .76 C

ATOM 1785 CG ARG B 42 -11. .862 -14. .695 26. .774 1. .00 21. .56 c

ATOM 1786 CD ARG B 42 -11. .284 -16. .086 27. .077 1. .00 23. .01 c

ATOM 1787 NE ARG B 42 -10. .428 -16. .172 28. .261 1. .00 25. .24 N

ATOM 1788 CZ ARG B 42 -10. .883 -16. .257 29. .513 1. .00 27. .08 C

ATOM 1789 NH1 ARG B 42 -12. .196 -16. .228 29. .755 1. .00 26. .67 N

ATOM 1790 NH2 ARG B 42 -10. .027 -16. .360 30. .530 1. .00 25. .92 N

ATOM 1791 N ASP B 43 -15. .692 -13. .933 26. .376 1. .00 22. .43 N

ATOM 1792 CA ASP B 43 -16. .636 -13. .235 27. .250 1. .00 24. .80 C

ATOM 1793 C ASP B 43 -17. .670 -14. .188 27. .786 1. .00 26. .78 C

ATOM 1794 O ASP B 43 -18. .029 -14. .123 28. .959 1. .00 29. .57 O

ATOM 1795 CB ASP B 43 -17. .351 -12. .113 26. .505 1. .00 24. .91 C

ATOM 1796 CG ASP B 43 -16. .556 -10. .843 26. .491 1. .00 24. .83 C

ATOM 1797 OD1 ASP B 43 -15. .302 -10. .930 26. .538 1. .00 25. .16 O

ATOM 1798 OD2 ASP B 43 -17. .184 -9. .767 26. .426 1. .00 24. .83 O

ATOM 1799 N LEU B 44 -18. .138 -15. .077 26. .917 1. .00 26. .39 N

ATOM 1800 CA LEU B 44 -19. .164 -16. .025 27. .287 1. .00 27. .52 C

ATOM 1801 C LEU B 44 -18. .610 -17. .006 28. .311 1. .00 27. .51 C

ATOM 1802 O LEU B 44 -19. .287 -17. .347 29. .270 1. .00 26. .74 O

ATOM 1803 CB LEU B 44 -19. .700 -16. .743 26. .045 1. .00 25. .97 C

ATOM 1804 CG LEU B 44 -20. .937 -17. .612 26. .215 1. .00 26. .02 c

ATOM 1805 CD1 LEU B 44 -22. .132 -16. .788 26. .692 1. .00 24. .65 c

ATOM 1806 CD2 LEU B 44 -21. .238 -18. .330 24. .897 1. .00 24. .88 c

ATOM 1807 N LYS B 45 -17. .367 -17. .437 28. .123 1. .00 29. .09 N

ATOM 1808 CA LYS B 45 -16. .705 -18. .276 29. .127 1. .00 29. .86 C

ATOM 1809 C LYS B 45 -16. .585 -17. .567 30. .488 1. .00 31. .38 C

ATOM 1810 O LYS B 45 -16. .835 -18. .192 31. .510 1. .00 33. .17 O

ATOM 1811 CB LYS B 45 -15. .338 -18. .754 28. .643 1. .00 28. .90 c

ATOM 1812 CG LYS B 45 -14. .544 -19. .597 29. .643 1. .00 28. .65 c

ATOM 1813 CD LYS B 45 -13. .195 -19. .938 29. .030 1. .00 29. .50 c

ATOM 1814 CE LYS B 45 -12. .163 -20. .456 30. .027 1. .00 31. .59 c

ATOM 1815 NZ LYS B 45 -12. .453 -21. .876 30. .356 1. .00 34. .36 N ATOM 1816 N PHE B 46 -16..234 -16..274 30..483 1..00 30..60 N

ATOM 1817 CA PHE B 46 -15. .964 -15. .506 31. .716 1. .00 31. .82 C

ATOM 1818 C PHE B 46 -17. .238 -15. .343 32. .511 1. .00 32. .98 C

ATOM 1819 O PHE B 46 -17. .263 -15. .582 33. .715 1. .00 34. .18 O

ATOM 1820 CB PHE B 46 -15. .395 -14. .106 31. .409 1. .00 31. .41 C

ATOM 1821 CG PHE B 46 -14. .363 -13. .634 32. .390 1. .00 31. .64 C

ATOM 1822 CD1 PHE B 46 -14. .731 -13. .142 33. .633 1. .00 33. .39 C

ATOM 1823 CD2 PHE B 46 -13. .014 -13. .649 32. .057 1. .00 33. .40 C

ATOM 1824 CE1 PHE B 46 -13. .774 -12. .700 34. .543 1. .00 34. .70 C

ATOM 1825 CE2 PHE B 46 -12. .044 -13. .213 32. .961 1. .00 33. .30 C

ATOM 1826 CZ PHE B 46 -12. .428 -12. .735 34. .207 1. .00 35. .38 C

ATOM 1827 N CYS B 47 -18. .285 -14. .930 31. .811 1. .00 33. .66 N

ATOM 1828 CA CYS B 47 -19. .580 -14. .599 32. .383 1. .00 34. .54 C

ATOM 1829 C CYS B 47 -20. .518 -15. .822 32. .572 1. .00 34. .51 C

ATOM 1830 O CYS B 47 -21. .500 -15. .755 33. .311 1. .00 36. .26 O

ATOM 1831 CB CYS B 47 -20. .244 -13. .519 31. .490 1. .00 35. .10 C

ATOM 1832 SG CYS B 47 -20. .202 -11. .802 32. .125 1. .00 39. .98 s

ATOM 1833 N HIS B 48 -20. .233 -16. .931 31. .895 1. .00 32. .33 N

ATOM 1834 CA HIS B 48 -21. .100 -18. .113 31. .958 1. .00 30. .32 C

ATOM 1835 C HIS B 48 -20. .258 -19. .357 31. .968 1. .00 30. .99 C

ATOM 1836 O HIS B 48 -20. .237 -20. .120 30. .991 1. .00 29. .44 O

ATOM 1837 CB HIS B 48 -22. .067 -18. .131 30. .785 1. .00 29. .97 C

ATOM 1838 CG HIS B 48 -23. .179 -17. .119 30. .888 1. .00 31. .93 c

ATOM 1839 ND1 HIS B 48 -24. .272 -17. .307 31. .661 1. .00 31. .93 N

ATOM 1840 CD2 HIS B 48 -23. .323 -15. .862 30. .303 1. .00 32. .87 C

ATOM 1841 CE1 HIS B 48 -25. .084 -16. .237 31. .558 1. .00 32. .48 C

ATOM 1842 NE2 HIS B 48 -24. .507 -15. .356 30. .721 1. .00 33. .26 N

ATOM 1843 N PRO B 49 -19. .531 -19. .586 33. .073 1. .00 31. .23 N

ATOM 1844 CA PRO B 49 -18. .565 -20. .679 33. .064 1. .00 30. .32 C

ATOM 1845 C PRO B 49 -19. .199 -22. .070 33. .093 1. .00 30. .71 C

ATOM 1846 O PRO B 49 -18. .481 -23. .058 32. .941 1. .00 32. .45 O

ATOM 1847 CB PRO B 49 -17. .729 -20. .429 34. .326 1. .00 31. .73 C

ATOM 1848 CG PRO B 49 -18. .619 -19. .646 35. .230 1. .00 30. .19 C

ATOM 1849 CD PRO B 49 -19. .562 -18. .864 34. .362 1. .00 30. .86 C

ATOM 1850 N GLU B 50 -20. .513 -22. .120 33. .246 1. .00 30. .50 N

ATOM 1851 CA GLU B 50 -21. .320 -23. .328 33. .215 1. .00 31. .47 C

ATOM 1852 C GLU B 50 -21. .485 -23. .927 31. .815 1. .00 30. .93 C

ATOM 1853 O GLU B 50 -21. .685 -25. .100 31. .670 1. .00 30. .45 O

ATOM 1854 CB GLU B 50 -22. .697 -23. .108 33. .904 1. .00 33. .19 C

ATOM 1855 CG GLU B 50 -23. .817 -22. .330 33. .175 1. .00 34. .21 c

ATOM 1856 CD GLU B 50 -23. .619 -20. .839 33. .185 1. .00 36. .47 c

ATOM 1857 OE1 GLU B 50 -22. .566 -20. .487 33. .681 1. .00 38. .82 0

ATOM 1858 OE2 GLU B 50 -24. .465 -20. .014 32. .751 1. .00 36. .70 0

ATOM 1859 N LEU B 51 -21. .363 -23. .104 30. .799 1. .00 28. .23 N

ATOM 1860 CA LEU B 51 -21. .675 -23. .520 29. .430 1. .00 27. .28 C

ATOM 1861 C LEU B 51 -20. .629 -24. .434 28. .808 1. .00 26. .26 C

ATOM 1862 O LEU B 51 -19. .442 -24. .221 28. .952 1. .00 26. .17 0

ATOM 1863 CB LEU B 51 -21. .928 -22. .323 28. .524 1. .00 25. .52 c

ATOM 1864 CG LEU B 51 -23. .090 -21. .433 28. .940 1. .00 25. .20 c

ATOM 1865 CD1 LEU B 51 -23. .084 -20. .187 28. .074 1. .00 24. .25 c

ATOM 1866 CD2 LEU B 51 -24. .430 -22. .153 28. .842 1. .00 26. .17 c

ATOM 1867 N LYS B 52 -21. .086 -25. .446 28. .088 1. .00 24. .95 N

ATOM 1868 CA LYS B 52 -20. .177 -26. .401 27. .489 1. .00 24. .36 C

ATOM 1869 C LYS B 52 -19. .828 -26. .004 26. .051 1. .00 22. .79 C

ATOM 1870 O LYS B 52 -20. .537 -25. .223 25. .413 1. .00 21. .92 0

ATOM 1871 CB LYS B 52 -20. .819 -27. .784 27. .527 1. .00 27. .71 c

ATOM 1872 CG LYS B 52 -21. .094 -28. .300 28. .941 1. .00 28. .14 c

ATOM 1873 CD LYS B 52 -21. .803 -29. .638 28. .875 1. .00 29. .87 c

ATOM 1874 CE LYS B 52 -22. .332 -30. .028 30. .245 1. .00 32. .55 c

ATOM 1875 NZ LYS B 52 -21. .202 -30. .513 31. .088 1. .00 37. .86 N

ATOM 1876 N SER B 53 -18. .728 -26. .539 25. .553 1. .00 21. .77 N ATOM 1877 CA SER B 53 -18..302 -26..281 24..196 1..00 21..49 C

ATOM 1878 C SER B 53 -19. .397 -26. .615 23. .212 1. .00 22. .00 C

ATOM 1879 O SER B 53 -20. .043 -27. .675 23. .291 1. .00 22. .15 O

ATOM 1880 CB SER B 53 -17. .053 -27. .078 23. .877 1. .00 21. .19 C

ATOM 1881 OG SER B 53 -16. .028 -26. .686 24. .762 1. .00 21. .50 O

ATOM 1882 N GLY B 54 -19. .606 -25. .710 22. .270 1. .00 20. .45 N

ATOM 1883 CA GLY B 54 -20. .620 -25. .932 21. .277 1. .00 19. .78 C

ATOM 1884 C GLY B 54 -20. .905 -24. .683 20. .494 1. .00 20. .06 C

ATOM 1885 O GLY B 54 -20. .106 -23. .743 20. .476 1. .00 18. .69 O

ATOM 1886 N GLU B 55 -22. .073 -24. .687 19. .866 1. .00 20. .44 N

ATOM 1887 CA GLU B 55 -22. .488 -23. .650 18. .956 1. .00 21. .22 C

ATOM 1888 C GLU B 55 -23. .156 -22. .502 19. .709 1. .00 20. .37 C

ATOM 1889 O GLU B 55 -24. .086 -22. .735 20. .483 1. .00 20. .26 O

ATOM 1890 CB GLU B 55 -23. .475 -24. .256 17. .957 1. .00 24. .41 C

ATOM 1891 CG GLU B 55 -24. .194 -23. .231 17. .101 1. .00 26. .20 c

ATOM 1892 CD GLU B 55 -25. .004 -23. .911 16. .025 1. .00 29. .94 c

ATOM 1893 OE1 GLU B 55 -26. .182 -24. .240 16. .288 1. .00 32. .54 0

ATOM 1894 OE2 GLU B 55 -24. .442 -24. .141 14. .932 1. .00 32. .86 0

ATOM 1895 N TYR B 56 -22. .684 -21. .277 19. .476 1. .00 19. .18 N

ATOM 1896 CA TYR B 56 -23. .287 -20. .093 20. .069 1. .00 18. .78 C

ATOM 1897 C TYR B 56 -23. .253 -18. .988 19. .032 1. .00 19. .92 C

ATOM 1898 O TYR B 56 -22. .596 -19. .125 17. .978 1. .00 18. .82 0

ATOM 1899 CB TYR B 56 -22. .523 -19. .637 21. .332 1. .00 18. .39 c

ATOM 1900 CG TYR B 56 -22. .553 -20. .677 22. .443 1. .00 19. .20 c

ATOM 1901 CD1 TYR B 56 -21. .591 -21. .687 22. .506 1. .00 18. .74 c

ATOM 1902 CD2 TYR B 56 -23. .576 -20. .681 23. .400 1. .00 18. .72 c

ATOM 1903 CE1 TYR B 56 -21. .636 -22. .659 23. .505 1. .00 19. .39 c

ATOM 1904 CE2 TYR B 56 -23. .624 -21. .642 24. .403 1. .00 19. .05 c

ATOM 1905 CZ TYR B 56 -22. .646 -22. .635 24. .453 1. .00 19. .33 c

ATOM 1906 OH TYR B 56 -22. .682 -23. .606 25. .456 1. .00 19. .20 0

ATOM 1907 N TRP B 57 -23. .955 -17. .898 19. .345 1. .00 18. .71 N

ATOM 1908 CA TRP B 57 -23. .981 -16. .706 18. .523 1. .00 18. .95 c

ATOM 1909 C TRP B 57 -23. .200 -15. .623 19. .192 1. .00 18. .79 c

ATOM 1910 O TRP B 57 -23. .360 -15. .382 20. .407 1. .00 18. .90 0

ATOM 1911 CB TRP B 57 -25. .410 -16. .258 18. .351 1. .00 20. .24 c

ATOM 1912 CG TRP B 57 -26. .189 -17. .195 17. .461 1. .00 21. .27 c

ATOM 1913 CD1 TRP B 57 -26. .772 -18. .410 17. .818 1. .00 21. .05 c

ATOM 1914 CD2 TRP B 57 -26. .488 -17. .029 16. .021 1. .00 20. .59 c

ATOM 1915 NE1 TRP B 57 -27. .401 -18. .970 16. .741 1. .00 22. .71 N

ATOM 1916 CE2 TRP B 57 -27. .289 -18. .188 15. .639 1. .00 21. .48 C

ATOM 1917 CE3 TRP B 57 -26. .227 -16. .046 15. .074 1. .00 20. .23 c

ATOM 1918 CZ2 TRP B 57 -27. .766 -18. .363 14. .338 1. .00 20. .90 c

ATOM 1919 CZ3 TRP B 57 -26. .717 -16. .220 13. .778 1. .00 20. .22 c

ATOM 1920 CH2 TRP B 57 -27. .452 -17. .359 13. .412 1. .00 20. .38 c

ATOM 1921 N VAL B 58 -22. .312 -14. .983 18. .436 1. .00 17. .51 N

ATOM 1922 CA VAL B 58 -21. .485 -13. .909 18. .998 1. .00 17. .67 C

ATOM 1923 C VAL B 58 -21. .559 -12. .663 18. .114 1. .00 18. .53 C

ATOM 1924 O VAL B 58 -21. .845 -12. .771 16. .926 1. .00 17. .88 0

ATOM 1925 CB VAL B 58 -20. .013 -14. .334 19. .245 1. .00 18. .00 c

ATOM 1926 CGI VAL B 58 -19. .939 -15. .494 20. .254 1. .00 17. .12 c

ATOM 1927 CG2 VAL B 58 -19. .301 -14. .698 17. .943 1. .00 16. .27 c

ATOM 1928 N ASP B 59 -21. .311 -11. .488 18. .700 1. .00 18. .39 N

ATOM 1929 CA ASP B 59 -21. .504 -10. .239 18. .000 1. .00 17. .79 C

ATOM 1930 C ASP B 59 -20. .344 -9. .332 18. .311 1. .00 17. .08 C

ATOM 1931 O ASP B 59 -20. .470 -8. .387 19. .098 1. .00 16. .97 0

ATOM 1932 CB ASP B 59 -22. .826 -9. .587 18. .418 1. .00 18. .90 c

ATOM 1933 CG ASP B 59 -23. .194 -8. .386 17. .537 1. .00 20. .00 c

ATOM 1934 OD1 ASP B 59 -22. .777 -8. .344 16. .354 1. .00 20. .08 0

ATOM 1935 OD2 ASP B 59 -23. .920 -7. .492 18. .011 1. .00 19. .75 0

ATOM 1936 N PRO B 60 -19. .193 -9. .623 17. .705 1. .00 17. .72 N

ATOM 1937 CA PRO B 60 -17. .965 -8. .870 17. .997 1. .00 17. .52 C ATOM 1938 C PRO B 60 -18..130 -7..371 17..835 1..00 17..74 C

ATOM 1939 O PRO B 60 -17. .501 -6. .627 18. .568 1. .00 16. .28 O

ATOM 1940 CB PRO B 60 -16. .967 -9. .398 16. .969 1. .00 17. .16 C

ATOM 1941 CG PRO B 60 -17. .460 -10. .774 16. .656 1. .00 17. .32 C

ATOM 1942 CD PRO B 60 -18. .951 -10. .739 16. .762 1. .00 17. .36 C

ATOM 1943 N ASN B 61 -18. .965 -6. .933 16. .891 1. .00 18. .32 N

ATOM 1944 CA ASN B 61 -19. .133 -5. .493 16. .687 1. .00 18. .96 C

ATOM 1945 C ASN B 61 -20. .194 -4. .840 17. .577 1. .00 19. .44 C

ATOM 1946 O ASN B 61 -20. .406 -3. .636 17. .486 1. .00 19. .09 O

ATOM 1947 CB ASN B 61 -19. .320 -5. .137 15. .205 1. .00 18. .45 C

ATOM 1948 CG ASN B 61 -20. .659 -5. .577 14. .631 1. .00 18. .76 C

ATOM 1949 OD1 ASN B 61 -21. .564 -6. .053 15. .335 1. .00 18. .24 0

ATOM 1950 ND2 ASN B 61 -20. .799 -5. .383 13. .321 1. .00 17. .55 N

ATOM 1951 N GLN B 62 -20. .835 -5. .638 18. .437 1. .00 19. .01 N

ATOM 1952 CA GLN B 62 -21. .853 -5. .153 19. .383 1. .00 20. .08 C

ATOM 1953 C GLN B 62 -22. .933 -4. .341 18. .672 1. .00 20. .47 C

ATOM 1954 O GLN B 62 -23. .367 -4. .734 17. .589 1. .00 20. .94 O

ATOM 1955 CB GLN B 62 -21. .221 -4. .378 20. .555 1. .00 20. .58 C

ATOM 1956 CG GLN B 62 -20. .312 -5. .232 21. .438 1. .00 22. .22 C

ATOM 1957 CD GLN B 62 -21. .082 -6. .299 22. .191 1. .00 23. .62 C

ATOM 1958 OE1 GLN B 62 -21. .304 -7. .425 21. .692 1. .00 25. .30 O

ATOM 1959 NE2 GLN B 62 -21. .521 -5. .953 23. .385 1. .00 22. .90 N

ATOM 1960 N GLY B 63 -23. .381 -3. .236 19. .268 1. .00 21. .42 N

ATOM 1961 CA GLY B 63 -24. .481 -2. .438 18. .681 1. .00 22. .48 C

ATOM 1962 C GLY B 63 -25. .692 -3. .335 18. .465 1. .00 22. .60 C

ATOM 1963 O GLY B 63 -26. .014 -4. .134 19. .330 1. .00 23. .09 O

ATOM 1964 N CYS B 64 -26. .320 -3. .247 17. .297 1. .00 24. .15 N

ATOM 1965 CA CYS B 64 -27. .422 -4. .152 16. .910 1. .00 25. .37 C

ATOM 1966 C CYS B 64 -27. .057 -5. .651 16. .999 1. .00 24. .10 C

ATOM 1967 O CYS B 64 -25. .996 -6. .069 16. .548 1. .00 23. .86 O

ATOM 1968 CB CYS B 64 -27. .863 -3. .828 15. .483 1. .00 27. .27 C

ATOM 1969 SG CYS B 64 -29. .474 -4. .463 14. .994 1. .00 27. .27 s

ATOM 1970 N LYS B 65 -27. .956 -6. .451 17. .557 1. .00 25. .02 N

ATOM 1971 CA LYS B 65 -27. .741 -7. .895 17. .711 1. .00 26. .43 C

ATOM 1972 C LYS B 65 -27. .935 -8. .675 16. .396 1. .00 24. .52 C

ATOM 1973 O LYS B 65 -27. .521 -9. .828 16. .265 1. .00 21. .79 O

ATOM 1974 CB LYS B 65 -28. .717 -8. .455 18. .744 1. .00 29. .50 C

ATOM 1975 CG LYS B 65 -28. .608 -7. .876 20. .154 1. .00 33. .86 c

ATOM 1976 CD LYS B 65 -29. .859 -8. .277 20. .943 1. .00 37. .20 c

ATOM 1977 CE LYS B 65 -29. .744 -8. .057 22. .445 1. .00 39. .34 c

ATOM 1978 NZ LYS B 65 -29. .692 -6. .608 22. .782 1. .00 41. .61 N

ATOM 1979 N LEU B 66 -28. .561 -8. .034 15. .420 1. .00 24. .09 N

ATOM 1980 CA LEU B 66 -29. .123 -8. .767 14. .286 1. .00 23. .83 C

ATOM 1981 C LEU B 66 -28. .092 -9. .283 13. .297 1. .00 23. .25 C

ATOM 1982 O LEU B 66 -28. .379 -10. .208 12. .542 1. .00 22. .29 O

ATOM 1983 CB LEU B 66 -30. .198 -7. .931 13. .595 1. .00 25. .30 C

ATOM 1984 CG LEU B 66 -31. .440 -7. .770 14. .488 1. .00 26. .75 C

ATOM 1985 CD1 LEU B 66 -32. .450 -6. .804 13. .880 1. .00 27. .42 C

ATOM 1986 CD2 LEU B 66 -32. .073 -9. .143 14. .712 1. .00 27. .62 C

ATOM 1987 N ASP B 67 -26. .887 -8. .704 13. .331 1. .00 21. .72 N

ATOM 1988 CA ASP B 67 -25. .802 -9. .149 12. .462 1. .00 20. .78 C

ATOM 1989 C ASP B 67 -24. .810 -10. .110 13. .160 1. .00 19. .30 C

ATOM 1990 O ASP B 67 -23. .664 -10. .271 12. .712 1. .00 18. .79 O

ATOM 1991 CB ASP B 67 -25. .085 -7. .944 11. .809 1. .00 20. .62 C

ATOM 1992 CG ASP B 67 -24. .399 -7. .017 12. .821 1. .00 21. .94 c

ATOM 1993 OD1 ASP B 67 -24. .524 -7. .229 14. .064 1. .00 21. .32 0

ATOM 1994 OD2 ASP B 67 -23. .701 -6. .061 12. .359 1. .00 21. .99 0

ATOM 1995 N ALA B 68 -25. .264 -10. .757 14. .232 1. .00 18. .21 N

ATOM 1996 CA ALA B 68 -24. .447 -11. .747 14. .951 1. .00 17. .91 C

ATOM 1997 C ALA B 68 -24. .054 -12. .906 14. .056 1. .00 17. .67 C

ATOM 1998 O ALA B 68 -24. .742 -13. .200 13. .075 1. .00 18. .53 O ATOM 1999 CB ALA B 68 -25..190 -12..274 16..163 1..00 17..62 C

ATOM 2000 N ILE B 69 -22. .948 -13. .556 14. .409 1. .00 17. .97 N

ATOM 2001 CA ILE B 69 -22. .409 -14. .691 13. .669 1. .00 18. .77 C

ATOM 2002 C ILE B 69 -22. .460 -15. .948 14. .507 1. .00 19. .24 C

ATOM 2003 O ILE B 69 -22. .409 -15. .905 15. .743 1. .00 18. .80 O

ATOM 2004 CB ILE B 69 -20. .969 -14. .461 13. .137 1. .00 19. .42 C

ATOM 2005 CGI ILE B 69 -19. .996 -14. .122 14. .267 1. .00 20. .65 C

ATOM 2006 CG2 ILE B 69 -20. .947 -13. .367 12. .067 1. .00 19. .99 c

ATOM 2007 CD1 ILE B 69 -18. .547 -14. .089 13. .817 1. .00 20. .68 c

ATOM 2008 N LYS B 70 -22. .580 -17. .073 13. .827 1. .00 19. .01 N

ATOM 2009 CA LYS B 70 -22. .714 -18. .328 14. .512 1. .00 20. .58 C

ATOM 2010 C LYS B 70 -21. .357 -19. .017 14. .538 1. .00 18. .93 C

ATOM 2011 O LYS B 70 -20. .679 -19. .118 13. .504 1. .00 18. .38 O

ATOM 2012 CB LYS B 70 -23. .775 -19. .179 13. .810 1. .00 22. .89 c

ATOM 2013 CG LYS B 70 -24. .129 -20. .437 14. .567 1. .00 26. .93 c

ATOM 2014 CD LYS B 70 -25. .247 -21. .190 13. .863 1. .00 31. .29 c

ATOM 2015 CE LYS B 70 -24. .746 -21. .867 12. .599 1. .00 35. .17 c

ATOM 2016 NZ LYS B 70 -25. .915 -22. .244 11. .750 1. .00 39. .57 N

ATOM 2017 N VAL B 71 -20. .944 -19. .461 15. .725 1. .00 17. .29 N

ATOM 2018 CA VAL B 71 -19. .593 -19. .968 15. .897 1. .00 16. .64 C

ATOM 2019 C VAL B 71 -19. .573 -21. .219 16. .764 1. .00 16. .94 C

ATOM 2020 O VAL B 71 -20. .578 -21. .544 17. .406 1. .00 16. .74 O

ATOM 2021 CB VAL B 71 -18. .652 -18. .893 16. .514 1. .00 16. .65 C

ATOM 2022 CGI VAL B 71 -18. .616 -17. .637 15. .669 1. .00 16. .30 C

ATOM 2023 CG2 VAL B 71 -19. .058 -18. .559 17. .947 1. .00 16. .31 C

ATOM 2024 N PHE B 72 -18. .427 -21. .907 16. .790 1. .00 16. .56 N

ATOM 2025 CA PHE B 72 -18. .150 -22. .899 17. .827 1. .00 17. .81 C

ATOM 2026 C PHE B 72 -17. .352 -22. .213 18. .953 1. .00 17. .30 C

ATOM 2027 O PHE B 72 -16. .313 -21. .598 18. .672 1. .00 16. .66 O

ATOM 2028 CB PHE B 72 -17. .360 -24. .103 17. .258 1. .00 17. .44 C

ATOM 2029 CG PHE B 72 -16. .980 -25. .145 18. .308 1. .00 17. .93 c

ATOM 2030 CD1 PHE B 72 -17. .895 -26. .114 18. .718 1. .00 17. .70 c

ATOM 2031 CD2 PHE B 72 -15. .701 -25. .160 18. .876 1. .00 17. .65 c

ATOM 2032 CE1 PHE B 72 -17. .541 -27. .079 19. .666 1. .00 18. .26 c

ATOM 2033 CE2 PHE B 72 -15. .343 -26. .119 19. .824 1. .00 18. .10 c

ATOM 2034 CZ PHE B 72 -16. .257 -27. .088 20. .218 1. .00 17. .58 c

ATOM 2035 N CYS B 73 -17. .834 -22. .305 20. .200 1. .00 16. .77 N

ATOM 2036 CA CYS B 73 -17. .052 -21. .853 21. .366 1. .00 17. .42 C

ATOM 2037 C CYS B 73 -16. .391 -23. .061 22. .003 1. .00 18. .33 c

ATOM 2038 O CYS B 73 -17. .079 -23. .995 22. .451 1. .00 18. .76 0

ATOM 2039 CB CYS B 73 -17. .908 -21. .135 22. .421 1. .00 16. .41 c

ATOM 2040 SG CYS B 73 -18. .664 -19. .567 21. .911 1. .00 15. .41 s

ATOM 2041 N ASN B 74 -15. .060 -23. .069 22. .007 1. .00 19. .66 N

ATOM 2042 CA ASN B 74 -14. .318 -23. .991 22. .876 1. .00 20. .71 C

ATOM 2043 C ASN B 74 -14. .325 -23. .391 24. .282 1. .00 20. .98 C

ATOM 2044 O ASN B 74 -13. .588 -22. .444 24. .559 1. .00 21. .77 0

ATOM 2045 CB ASN B 74 -12. .880 -24. .192 22. .366 1. .00 20. .51 c

ATOM 2046 CG ASN B 74 -12. .148 -25. .332 23. .089 1. .00 20. .53 c

ATOM 2047 OD1 ASN B 74 -12. .308 -25. .510 24. .285 1. .00 20. .94 0

ATOM 2048 ND2 ASN B 74 -11. .336 -26. .092 22. .360 1. .00 19. .46 N

HETATM 2049 N MSE B 75 -15. .166 -23. .925 25. .162 1. .00 20. .96 N

HETATM 2050 CA MSE B 75 -15. .285 -23. .381 26. .519 1. .00 22. .51 C

HETATM 2051 C MSE B 75 -14. .142 -23. .752 27. .444 1. .00 23. .28 C

HETATM 2052 O MSE B 75 -14. .015 -23. .178 28. .523 1. .00 22. .92 O

HETATM 2053 CB MSE B 75 -16. .629 -23. .736 27. .148 1. .00 25. .06 C

HETATM 2054 CG MSE B 75 -17. .756 -23. .134 26. .331 1. .00 28. .53 C

HETATM 2055 SE MSE B 75 -17. .555 -21. .171 26. .272 1. .00 37. .37 SE

HETATM 2056 CE MSE B 75 -19. .459 -20. .889 25. .911 1. .00 34. .28 C

ATOM 2057 N GLU B 76 -13. .277 -24. .677 27. .033 1. .00 22. .62 N

ATOM 2058 CA GLU B 76 -12. .099 -24. .972 27. .834 1. .00 23. .87 C

ATOM 2059 C GLU B 76 -11. .049 -23. .855 27. .631 1. .00 24. .88 C ATOM 2060 O GLU B 76 -10..508 -23..299 28..597 1..00 24..85 O

ATOM 2061 CB GLU B 76 -11. .560 -26. .374 27. .495 1. .00 23. .56 C

ATOM 2062 CG GLU B 76 -10. .598 -26. .923 28. .538 1. .00 27. .70 C

ATOM 2063 N THR B 77 -10. .813 -23. .483 26. .373 1. .00 24. .61 N

ATOM 2064 CA THR B 77 -9. .812 -22. .459 26. .038 1. .00 25. .17 C

ATOM 2065 C THR B 77 -10. .378 -21. .039 25. .944 1. .00 26. .00 C

ATOM 2066 O THR B 77 -9. .637 -20. .084 26. .091 1. .00 27. .65 O

ATOM 2067 CB THR B 77 -9. .118 -22. .763 24. .698 1. .00 25. .67 C

ATOM 2068 OG1 THR B 77 -10. .103 -22. .792 23. .659 1. .00 26. .33 0

ATOM 2069 CG2 THR B 77 -8. .412 -24. .110 24. .734 1. .00 24. .97 c

ATOM 2070 N GLY B 78 -11. .682 -20. .907 25. .694 1. .00 25. .72 N

ATOM 2071 CA GLY B 78 -12. .309 -19. .611 25. .484 1. .00 22. .62 C

ATOM 2072 C GLY B 78 -12. .256 -19. .127 24. .048 1. .00 20. .67 C

ATOM 2073 O GLY B 78 -12. .569 -17. .978 23. .771 1. .00 19. .66 O

ATOM 2074 N GLU B 79 -11. .837 -20. .001 23. .144 1. .00 20. .03 N

ATOM 2075 CA GLU B 79 -11. .634 -19. .659 21. .750 1. .00 20. .00 C

ATOM 2076 C GLU B 79 -12. .943 -19. .550 20. .975 1. .00 18. .93 C

ATOM 2077 O GLU B 79 -13. .850 -20. .347 21. .174 1. .00 18. .20 O

ATOM 2078 CB GLU B 79 -10. .786 -20. .723 21. .065 1. .00 21. .45 C

ATOM 2079 CG GLU B 79 -9. .289 -20. .695 21. .331 1. .00 22. .74 c

ATOM 2080 CD GLU B 79 -8. .649 -21. .970 20. .824 1. .00 24. .60 c

ATOM 2081 OE1 GLU B 79 -9. .011 -23. .058 21. .338 1. .00 25. .84 0

ATOM 2082 OE2 GLU B 79 -7. .835 -21. .903 19. .875 1. .00 24. .69 0

ATOM 2083 N THR B 80 -12. .997 -18. .584 20. .065 1. .00 17. .39 N

ATOM 2084 CA THR B 80 -14. .133 -18. .378 19. .181 1. .00 16. .91 C

ATOM 2085 C THR B 80 -13. .711 -18. .899 17. .815 1. .00 16. .85 C

ATOM 2086 O THR B 80 -12. .781 -18. .371 17. .226 1. .00 16. .74 0

ATOM 2087 CB THR B 80 -14. .415 -16. .862 19. .037 1. .00 16. .59 c

ATOM 2088 OG1 THR B 80 -14. .660 -16. .289 20. .322 1. .00 16. .53 0

ATOM 2089 CG2 THR B 80 -15. .636 -16. .587 18. .146 1. .00 17. .06 c

ATOM 2090 N CYS B 81 -14. .382 -19. .924 17. .311 1. .00 16. .66 N

ATOM 2091 CA CYS B 81 -13. .954 -20. .571 16. .073 1. .00 17. .15 C

ATOM 2092 C CYS B 81 -14. .982 -20. .423 14. .953 1. .00 17. .47 C

ATOM 2093 O CYS B 81 -16. .116 -20. .875 15. .082 1. .00 18. .50 0

ATOM 2094 CB CYS B 81 -13. .673 -22. .067 16. .326 1. .00 17. .17 c

ATOM 2095 SG CYS B 81 -12. .350 -22. .366 17. .506 1. .00 17. .11 s

ATOM 2096 N ILE B 82 -14. .577 -19. .824 13. .839 1. .00 18. .00 N

ATOM 2097 CA ILE B 82 -15. .500 -19. .564 12. .736 1. .00 19. .01 C

ATOM 2098 C ILE B 82 -15. .229 -20. .517 11. .559 1. .00 19. .07 C

ATOM 2099 O ILE B 82 -14. .129 -20. .551 11. .022 1. .00 18. .29 O

ATOM 2100 CB ILE B 82 -15. .428 -18. .081 12. .291 1. .00 19. .27 c

ATOM 2101 CGI ILE B 82 -15. .571 -17. .182 13. .524 1. .00 19. .89 c

ATOM 2102 CG2 ILE B 82 -16. .530 -17. .791 11. .268 1. .00 19. .73 c

ATOM 2103 CD1 ILE B 82 -15. .565 -15. .703 13. .227 1. .00 21. .14 c

ATOM 2104 N SER B 83 -16. .230 -21. .294 11. .171 1. .00 19. .71 N

ATOM 2105 CA SER B 83 -16. .052 -22. .237 10. .073 1. .00 20. .70 C

ATOM 2106 C SER B 83 -15. .948 -21. .525 8. .736 1. .00 21. .91 C

ATOM 2107 O SER B 83 -16. .537 -20. .450 8. .553 1. .00 22. .83 0

ATOM 2108 CB SER B 83 -17. .206 -23. .227 10. .044 1. .00 20. .76 c

ATOM 2109 OG SER B 83 -17. .186 -23. .997 11. .235 1. .00 21. .60 0

ATOM 2110 N ALA B 84 -15. .190 -22. .108 7. .828 1. .00 22. .04 N

ATOM 2111 CA ALA B 84 -15. .113 -21. .706 6. .449 1. .00 22. .70 C

ATOM 2112 C ALA B 84 -16. .358 -22. .106 5. .688 1. .00 24. .32 C

ATOM 2113 O ALA B 84 -16. .919 -23. .110 5. .946 1. .00 24. .58 O

ATOM 2114 CB ALA B 84 -13. .913 -22. .331 5. .808 1. .00 20. .77 c

ATOM 2115 N ASN B 85 -16. .774 -21. .283 4. .757 1. .00 27. .78 N

ATOM 2116 CA ASN B 85 -17. .824 -21. .622 3. .836 1. .00 32. .63 C

ATOM 2117 C ASN B 85 -17. .413 -21. .306 2. .438 1. .00 34. .34 C

ATOM 2118 O ASN B 85 -17. .262 -20. .165 2. .112 1. .00 38. .60 O

ATOM 2119 CB ASN B 85 -19. .040 -20. .781 4. .127 1. .00 38. .13 C

ATOM 2120 CG ASN B 85 -20. .202 -21. .598 4. .592 1. .00 41. .81 c ATOM 2121 OD1 ASN B 85 -20..852 -22..277 3..810 1..00 42..83 O

ATOM 2122 ND2 ASN B 85 -20. .461 -21. .547 5. .876 1. .00 44. .62 N

ATOM 2123 N PRO B 86 -17. .291 -22. .296 1. .582 1. .00 33. .90 N

ATOM 2124 CA PRO B 86 -17. .431 -23. .693 1. .932 1. .00 32. .74 C

ATOM 2125 C PRO B 86 -16. .253 -24. .238 2. .717 1. .00 31. .18 C

ATOM 2126 O PRO B 86 -15. .230 -23. .639 2. .809 1. .00 31. .10 O

ATOM 2127 CB PRO B 86 -17. .497 -24. .356 0. .570 1. .00 33. .62 C

ATOM 2128 CG PRO B 86 -16. .605 -23. .529 -0. .263 1. .00 34. .99 C

ATOM 2129 CD PRO B 86 -16. .692 -22. .133 0. .258 1. .00 35. .58 C

ATOM 2130 N LEU B 87 -16. .463 -25. .387 3. .312 1. .00 32. .73 N

ATOM 2131 CA LEU B 87 -15. .464 -26. .046 4. .146 1. .00 34. .56 C

ATOM 2132 C LEU B 87 -14. .338 -26. .638 3. .306 1. .00 35. .33 C

ATOM 2133 O LEU B 87 -13. .187 -26. .691 3. .734 1. .00 35. .03 O

ATOM 2134 CB LEU B 87 -16. .129 -27. .164 4. .957 1. .00 34. .63 C

ATOM 2135 CG LEU B 87 -17. .167 -26. .738 6. .015 1. .00 39. .54 c

ATOM 2136 CD1 LEU B 87 -18. .142 -27. .854 6. .401 1. .00 37. .44 c

ATOM 2137 CD2 LEU B 87 -16. .464 -26. .190 7. .251 1. .00 38. .19 c

ATOM 2138 N ASN B 88 -14. .673 -27. .096 2. .110 1. .00 34. .63 N

ATOM 2139 CA ASN B 88 -13. .712 -27. .863 1. .354 1. .00 37. .37 C

ATOM 2140 C ASN B 88 -13. .539 -27. .456 -0. .104 1. .00 34. .32 C

ATOM 2141 O ASN B 88 -14. .400 -26. .820 -0. .704 1. .00 32. .92 O

ATOM 2142 CB ASN B 88 -14. .012 -29. .360 1. .468 1. .00 41. .76 c

ATOM 2143 CG ASN B 88 -15. .215 -29. .764 0. .667 1. .00 45. .96 c

ATOM 2144 OD1 ASN B 88 -16. .320 -29. .282 0. .917 1. .00 52. .59 0

ATOM 2145 ND2 ASN B 88 -15. .014 -30. .651 -0. .307 1. .00 46. .30 N

ATOM 2146 N VAL B 89 -12. .379 -27. .816 -0. .630 1. .00 32. .56 N

ATOM 2147 CA VAL B 89 -12. .071 -27. .747 -2. .038 1. .00 31. .50 C

ATOM 2148 C VAL B 89 -12. .067 -29. .213 -2. .448 1. .00 30. .26 C

ATOM 2149 O VAL B 89 -11. .293 -29. .983 -1. .907 1. .00 27. .41 O

ATOM 2150 CB VAL B 89 -10. .689 -27. .095 -2. .269 1. .00 30. .63 C

ATOM 2151 CGI VAL B 89 -10. .225 -27. .273 -3. .705 1. .00 29. .88 C

ATOM 2152 CG2 VAL B 89 -10. .744 -25. .623 -1. .921 1. .00 30. .12 C

ATOM 2153 N PRO B 90 -12. .979 -29. .612 -3. .364 1. .00 32. .00 N

ATOM 2154 CA PRO B 90 -13. .069 -31. .033 -3. .770 1. .00 31. .73 C

ATOM 2155 C PRO B 90 -11. .766 -31. .539 -4. .390 1. .00 31. .02 C

ATOM 2156 O PRO B 90 -10. .974 -30. .762 -4. .924 1. .00 31. .14 O

ATOM 2157 CB PRO B 90 -14. .206 -31. .043 -4. .816 1. .00 31. .20 C

ATOM 2158 CG PRO B 90 -14. .977 -29. .785 -4. .580 1. .00 31. .33 c

ATOM 2159 CD PRO B 90 -13. .995 -28. .775 -4. .036 1. .00 30. .75 c

ATOM 2160 N ARG B 91 -11. .548 -32. .840 -4. .294 1. .00 33. .16 N

ATOM 2161 CA ARG B 91 -10. .379 -33. .482 -4. .861 1. .00 34. .01 C

ATOM 2162 C ARG B 91 -10. .474 -33. .460 -6. .371 1. .00 35. .34 C

ATOM 2163 O ARG B 91 -11. .445 -33. .956 -6. .920 1. .00 35. .40 O

ATOM 2164 CB ARG B 91 -10. .357 -34. .925 -4. .383 1. .00 37. .36 c

ATOM 2165 CG ARG B 91 -9. .931 -35. .104 -2. .931 1. .00 40. .53 c

ATOM 2166 CD ARG B 91 -10. .762 -36. .195 -2. .291 1. .00 42. .87 c

ATOM 2167 NE ARG B 91 -10. .028 -36. .975 -1. .306 1. .00 46. .71 N

ATOM 2168 CZ ARG B 91 -9. .686 -38. .250 -1. .478 1. .00 50. .26 C

ATOM 2169 NH1 ARG B 91 -10. .005 -38. .894 -2. .604 1. .00 52. .66 N

ATOM 2170 NH2 ARG B 91 -9. .029 -38. .889 -0. .522 1. .00 49. .82 N

ATOM 2171 N LYS B 92 -9. .482 -32. .883 -7. .047 1. .00 37. .92 N

ATOM 2172 CA LYS B 92 -9. .523 -32. .769 -8. .511 1. .00 38. .90 C

ATOM 2173 C LYS B 92 -8. .151 -32. .575 -9. .117 1. .00 39. .65 C

ATOM 2174 O LYS B 92 -7. .192 -32. .195 -8. .427 1. .00 36. .92 O

ATOM 2175 CB LYS B 92 -10. .394 -31. .579 -8. .943 1. .00 42. .99 C

ATOM 2176 CG LYS B 92 -11. .852 -31. .893 -9. .262 1. .00 46. .65 C

ATOM 2177 CD LYS B 92 -12. .584 -30. .661 -9. .785 1. .00 49. .05 C

ATOM 2178 CE LYS B 92 -14. .095 -30. .812 -9. .649 1. .00 54. .36 C

ATOM 2179 NZ LYS B 92 -14. .821 -29. .513 -9. .787 1. .00 56. .75 N

ATOM 2180 N HIS B 93 -8. .064 -32. .832 -10. .420 1. .00 38. .09 N

ATOM 2181 CA HIS B 93 -6. .935 -32. .378 -11. .215 1. .00 40. .07 C ATOM 2182 C HIS B 93 -7..160 -30..913 -11..531 1..00 41..13 C

ATOM 2183 O HIS B 93 -7. .771 -30. .569 -12. .539 1. .00 44. .77 O

ATOM 2184 CB HIS B 93 -6. .784 -33. .250 -12. .471 1. .00 42. .51 C

ATOM 2185 CG HIS B 93 -5. .693 -32. .792 -13. .411 1. .00 44. .67 C

ATOM 2186 ND1 HIS B 93 -4. .393 -33. .064 -13. .198 1. .00 47. .03 N

ATOM 2187 CD2 HIS B 93 -5. .754 -32. .053 -14. .597 1. .00 47. .01 C

ATOM 2188 CE1 HIS B 93 -3. .653 -32. .522 -14. .186 1. .00 47. .37 C

ATOM 2189 NE2 HIS B 93 -4. .489 -31. .909 -15. .045 1. .00 48. .67 N

ATOM 2190 N TRP B 94 -6. .692 -30. .035 -10. .650 1. .00 37. .76 N

ATOM 2191 CA TRP B 94 -6. .994 -28. .602 -10. .746 1. .00 35. .81 C

ATOM 2192 C TRP B 94 -6. .070 -27. .836 -11. .675 1. .00 36. .12 C

ATOM 2193 O TRP B 94 -6. .438 -26. .794 -12. .217 1. .00 34. .06 O

ATOM 2194 CB TRP B 94 -6. .938 -27. .956 -9. .353 1. .00 33. .00 C

ATOM 2195 CG TRP B 94 -8. .065 -28. .330 -8. .409 1. .00 33. .63 C

ATOM 2196 CD1 TRP B 94 -8. .037 -29. .270 -7. .378 1. .00 32. .78 C

ATOM 2197 CD2 TRP B 94 -9. .430 -27. .769 -8. .379 1. .00 33. .59 C

ATOM 2198 NE1 TRP B 94 -9. .250 -29. .335 -6. .742 1. .00 32. .91 N

ATOM 2199 CE2 TRP B 94 -10. .132 -28. .460 -7. .289 1. .00 33. .21 C

ATOM 2200 CE3 TRP B 94 -10. .112 -26. .790 -9. .118 1. .00 33. .14 C

ATOM 2201 CZ2 TRP B 94 -11. .464 -28. .187 -6. .975 1. .00 33. .17 C

ATOM 2202 CZ3 TRP B 94 -11. .455 -26. .522 -8. .793 1. .00 34. .15 C

ATOM 2203 CH2 TRP B 94 -12. .114 -27. .207 -7. .747 1. .00 33. .98 c

ATOM 2204 N TRP B 95 -4. .839 -28. .303 -11. .834 1. .00 34. .40 N

ATOM 2205 CA TRP B 95 -3. .864 -27. .524 -12. .583 1. .00 33. .97 C

ATOM 2206 C TRP B 95 -3. .142 -28. .378 -13. .562 1. .00 35. .21 C

ATOM 2207 O TRP B 95 -2. .603 -29. .439 -13. .210 1. .00 33. .17 O

ATOM 2208 CB TRP B 95 -2. .877 -26. .876 -11. .628 1. .00 33. .47 C

ATOM 2209 CG TRP B 95 -1. .848 -25. .990 -12. .286 1. .00 33. .16 c

ATOM 2210 CD1 TRP B 95 -0. .491 -26. .254 -12. .475 1. .00 32. .57 c

ATOM 2211 CD2 TRP B 95 -2. .059 -24. .644 -12. .846 1. .00 33. .09 c

ATOM 2212 NE1 TRP B 95 0. .133 -25. .198 -13. .090 1. .00 33. .14 N

ATOM 2213 CE2 TRP B 95 -0. .750 -24. .198 -13. .343 1. .00 33. .63 C

ATOM 2214 CE3 TRP B 95 -3. .159 -23. .801 -12. .981 1. .00 33. .59 C

ATOM 2215 CZ2 TRP B 95 -0. .576 -22. .956 -13. .940 1. .00 33. .03 C

ATOM 2216 CZ3 TRP B 95 -2. .970 -22. .547 -13. .579 1. .00 33. .16 c

ATOM 2217 CH2 TRP B 95 -1. .713 -22. .139 -14. .053 1. .00 33. .79 c

ATOM 2218 N THR B 96 -3. .136 -27. .920 -14. .807 1. .00 36. .81 N

ATOM 2219 CA THR B 96 -2. .385 -28. .566 -15. .864 1. .00 37. .58 C

ATOM 2220 C THR B 96 -1. .320 -27. .626 -16. .366 1. .00 40. .45 C

ATOM 2221 O THR B 96 -1. .608 -26. .502 -16. .793 1. .00 40. .56 O

ATOM 2222 CB THR B 96 -3. .297 -28. .948 -17. .037 1. .00 39. .69 c

ATOM 2223 OG1 THR B 96 -4. .233 -29. .932 -16. .591 1. .00 40. .76 0

ATOM 2224 CG2 THR B 96 -2. .471 -29. .526 -18. .211 1. .00 39. .25 c

ATOM 2225 N ASP B 97 -0. .082 -28. .091 -16. .298 1. .00 42. .16 N

ATOM 2226 CA ASP B 97 1. .033 -27. .432 -16. .949 1. .00 42. .41 C

ATOM 2227 C ASP B 97 1. .915 -28. .532 -17. .533 1. .00 44. .51 C

ATOM 2228 O ASP B 97 2. .779 -29. .087 -16. .845 1. .00 41. .59 O

ATOM 2229 CB ASP B 97 1. .803 -26. .567 -15. .957 1. .00 44. .09 c

ATOM 2230 CG ASP B 97 2. .975 -25. .832 -16. .603 1. .00 48. .49 c

ATOM 2231 OD1 ASP B 97 3. .285 -26. .090 -17. .788 1. .00 47. .94 0

ATOM 2232 OD2 ASP B 97 3. .595 -24. .993 -15. .914 1. .00 51. .11 0

ATOM 2233 N SER B 98 1. .685 -28. .843 -18. .809 1. .00 46. .97 N

ATOM 2234 CA SER B 98 2. .380 -29. .947 -19. .488 1. .00 46. .32 C

ATOM 2235 C SER B 98 3. .798 -29. .582 -19. .961 1. .00 44. .75 C

ATOM 2236 O SER B 98 4. .506 -30. .421 -20. .520 1. .00 46. .20 0

ATOM 2237 CB SER B 98 1. .528 -30. .520 -20. .637 1. .00 47. .33 c

ATOM 2238 OG SER B 98 1. .680 -29. .762 -21. .825 1. .00 49. .63 0

ATOM 2239 N SER B 99 4. .213 -28. .339 -19. .725 1. .00 43. .95 N

ATOM 2240 CA SER B 99 5. .620 -27. .958 -19. .888 1. .00 44. .30 C

ATOM 2241 C SER B 99 6. .484 -28. .589 -18. .774 1. .00 42. .23 C

ATOM 2242 O SER B 99 7. .710 -28. .447 -18. .772 1. .00 41. .51 O ATOM 2243 CB SER B 99 5..776 -26..431 -19..879 1..00 43..41 C

ATOM 2244 OG SER B 99 5. .768 -25. .924 -18. .554 1. .00 43. .43 O

ATOM 2245 N ALA B 100 5. .823 -29. .266 -17. .834 1. .00 40. .91 N

ATOM 2246 CA ALA B 100 6. .463 -29. .954 -16. .699 1. .00 42. .13 C

ATOM 2247 C ALA B 100 7. .233 -29. .014 -15. .756 1. .00 41. .69 C

ATOM 2248 O ALA B 100 7. .960 -29. .467 -14. .859 1. .00 41. .53 O

ATOM 2249 CB ALA B 100 7. .347 -31. .111 -17. .187 1. .00 41. .09 C

ATOM 2250 N GLU B 101 7. .070 -27. .709 -15. .971 1. .00 40. .77 N

ATOM 2251 CA GLU B 101 7. .566 -26. .698 -15. .044 1. .00 42. .88 C

ATOM 2252 C GLU B 101 6. .865 -26. .837 -13. .676 1. .00 41. .17 C

ATOM 2253 O GLU B 101 5. .665 -27. .082 -13. .605 1. .00 38. .38 O

ATOM 2254 CB GLU B 101 7. .338 -25. .300 -15. .627 1. .00 47. .10 C

ATOM 2255 CG GLU B 101 8. .294 -24. .233 -15. .112 1. .00 51. .66 c

ATOM 2256 CD GLU B 101 9. .752 -24. .516 -15. .460 1. .00 54. .66 c

ATOM 2257 OE1 GLU B 101 10. .076 -24. .605 -16. .673 1. .00 54. .14 0

ATOM 2258 OE2 GLU B 101 10. .574 -24. .645 -14. .518 1. .00 52. .39 0

ATOM 2259 N LYS B 102 7. .625 -26. .716 -12. .595 1. .00 40. .00 N

ATOM 2260 CA LYS B 102 7. .031 -26. .687 -11. .257 1. .00 37. .99 C

ATOM 2261 C LYS B 102 7. .186 -25. .278 -10. .664 1. .00 37. .62 C

ATOM 2262 O LYS B 102 8. .240 -24. .645 -10. .802 1. .00 38. .40 0

ATOM 2263 CB LYS B 102 7. .620 -27. .778 -10. .347 1. .00 34. .89 c

ATOM 2264 CG LYS B 102 7. .482 -29. .225 -10. .855 1. .00 33. .28 c

ATOM 2265 CD LYS B 102 6. .041 -29. .608 -11. .182 1. .00 34. .41 c

ATOM 2266 CE LYS B 102 5. .931 -31. .021 -11. .759 1. .00 34. .15 c

ATOM 2267 NZ LYS B 102 4. .621 -31. .212 -12. .457 1. .00 34. .00 N

ATOM 2268 N LYS B 103 6. .127 -24. .800 -10. .013 1. .00 35. .89 N

ATOM 2269 CA LYS B 103 5. .982 -23. .385 -9. .601 1. .00 36. .20 C

ATOM 2270 C LYS B 103 4. .801 -23. .278 -8. .613 1. .00 31. .89 C

ATOM 2271 O LYS B 103 3. .855 -24. .073 -8. .687 1. .00 28. .58 O

ATOM 2272 CB LYS B 103 5. .743 -22. .519 -10. .864 1. .00 38. .17 C

ATOM 2273 CG LYS B 103 5. .138 -21. .133 -10. .668 1. .00 42. .28 C

ATOM 2274 CD LYS B 103 4. .234 -20. .756 -11. .852 1. .00 44. .85 C

ATOM 2275 CE LYS B 103 3. .534 -19. .397 -11. .681 1. .00 46. .78 c

ATOM 2276 NZ LYS B 103 2. .203 -19. .416 -10. .981 1. .00 47. .80 N

ATOM 2277 N HIS B 104 4. .854 -22. .327 -7. .680 1. .00 30. .47 N

ATOM 2278 CA HIS B 104 3. .680 -22. .074 -6. .845 1. .00 31. .25 C

ATOM 2279 C HIS B 104 2. .591 -21. .475 -7. .667 1. .00 30. .61 C

ATOM 2280 O HIS B 104 2. .807 -20. .489 -8. .377 1. .00 30. .76 O

ATOM 2281 CB HIS B 104 4. .006 -21. .173 -5. .667 1. .00 30. .69 C

ATOM 2282 CG HIS B 104 4. .938 -21. .805 -4. .682 1. .00 31. .41 C

ATOM 2283 ND1 HIS B 104 4. .584 -22. .872 -3. .935 1. .00 32. .17 N

ATOM 2284 CD2 HIS B 104 6. .259 -21. .515 -4. .360 1. .00 29. .02 C

ATOM 2285 CE1 HIS B 104 5. .623 -23. .225 -3. .152 1. .00 30. .53 C

ATOM 2286 NE2 HIS B 104 6. .645 -22. .397 -3. .419 1. .00 30. .71 N

ATOM 2287 N VAL B 105 1. .416 -22. .085 -7. .599 1. .00 30. .27 N

ATOM 2288 CA VAL B 105 0. .246 -21. .562 -8. .283 1. .00 30. .42 C

ATOM 2289 C VAL B 105 -0. .886 -21. .414 -7. .260 1. .00 30. .76 C

ATOM 2290 O VAL B 105 -1. .330 -22. .414 -6. .677 1. .00 28. .63 O

ATOM 2291 CB VAL B 105 -0. .202 -22. .508 -9. .419 1. .00 32. .71 C

ATOM 2292 CGI VAL B 105 -1. .476 -22. .005 -10. .078 1. .00 31. .46 C

ATOM 2293 CG2 VAL B 105 0. .899 -22. .681 -10. .461 1. .00 34. .21 C

ATOM 2294 N TRP B 106 -1. .329 -20. .172 -7. .032 1. .00 29. .38 N

ATOM 2295 CA TRP B 106 -2. .469 -19. .909 -6. .147 1. .00 27. .50 C

ATOM 2296 C TRP B 106 -3. .718 -20. .518 -6. .696 1. .00 28. .19 C

ATOM 2297 O TRP B 106 -4. .072 -20. .252 -7. .845 1. .00 28. .55 O

ATOM 2298 CB TRP B 106 -2. .671 -18. .413 -5. .921 1. .00 26. .78 C

ATOM 2299 CG TRP B 106 -1. .550 -17. .839 -5. .116 1. .00 27. .19 c

ATOM 2300 CD1 TRP B 106 -0. .506 -17. .042 -5. .568 1. .00 27. .66 c

ATOM 2301 CD2 TRP B 106 -1. .262 -18. .084 -3. .693 1. .00 26. .74 c

ATOM 2302 NE1 TRP B 106 0. .380 -16. .777 -4. .554 1. .00 28. .64 N

ATOM 2303 CE2 TRP B 106 -0. .024 -17. .359 -3. .396 1. .00 27. .70 C ATOM 2304 CE3 TRP B 106 -1..897 -18..784 -2..671 1..00 26..41 C

ATOM 2305 CZ2 TRP B 106 0. .536 -17. .342 -2. .118 1. .00 27. .48 C

ATOM 2306 CZ3 TRP B 106 -1. .309 -18. .772 -1. .384 1. .00 25. .51 C

ATOM 2307 CH2 TRP B 106 -0. .128 -18. .074 -1. .121 1. .00 25. .16 C

ATOM 2308 N PHE B 107 -4. .381 -21. .349 -5. .883 1. .00 25. .84 N

ATOM 2309 CA PHE B 107 -5. .687 -21. .907 -6. .206 1. .00 27. .32 C

ATOM 2310 C PHE B 107 -6. .761 -20. .835 -6. .494 1. .00 29. .75 C

ATOM 2311 O PHE B 107 -7. .363 -20. .834 -7. .562 1. .00 30. .38 O

ATOM 2312 CB PHE B 107 -6. .133 -22. .846 -5. .086 1. .00 25. .56 C

ATOM 2313 CG PHE B 107 -7. .565 -23. .292 -5. .176 1. .00 24. .98 C

ATOM 2314 CD1 PHE B 107 -7. .949 -24. .306 -6. .056 1. .00 24. .11 c

ATOM 2315 CD2 PHE B 107 -8. .529 -22. .742 -4. .339 1. .00 23. .55 c

ATOM 2316 CE1 PHE B 107 -9. .273 -24. .727 -6. .119 1. .00 24. .12 c

ATOM 2317 CE2 PHE B 107 -9. .850 -23. .150 -4. .407 1. .00 21. .80 c

ATOM 2318 CZ PHE B 107 -10. .227 -24. .143 -5. .291 1. .00 23. .52 c

ATOM 2319 N GLY B 108 -7. .005 -19. .944 -5. .535 1. .00 31. .27 N

ATOM 2320 CA GLY B 108 -7. .995 -18. .877 -5. .686 1. .00 31. .10 C

ATOM 2321 C GLY B 108 -7. .685 -17. .841 -6. .761 1. .00 32. .05 C

ATOM 2322 O GLY B 108 -8. .562 -17. .472 -7. .514 1. .00 31. .23 0

ATOM 2323 N GLU B 109 -6. .445 -17. .350 -6. .812 1. .00 34. .65 N

ATOM 2324 CA GLU B 109 -6. .020 -16. .390 -7. .835 1. .00 36. .79 C

ATOM 2325 C GLU B 109 -5. .923 -16. .939 -9. .257 1. .00 36. .37 C

ATOM 2326 O GLU B 109 -6. .250 -16. .229 -10. .199 1. .00 35. .98 O

ATOM 2327 CB GLU B 109 -4. .667 -15. .779 -7. .486 1. .00 40. .53 C

ATOM 2328 CG GLU B 109 -4. .731 -14. .442 -6. .782 1. .00 43. .27 c

ATOM 2329 CD GLU B 109 -3. .350 -13. .922 -6. .439 1. .00 46. .01 c

ATOM 2330 OE1 GLU B 109 -2. .434 -14. .052 -7. .289 1. .00 48. .11 0

ATOM 2331 OE2 GLU B 109 -3. .172 -13. .404 -5. .315 1. .00 45. .39 0

ATOM 2332 N SER B 110 -5. .470 -18. .180 -9. .430 1. .00 34. .85 N

ATOM 2333 CA SER B 110 -5. .095 -18. .630 -10. .786 1. .00 33. .52 C

ATOM 2334 C SER B 110 -5. .767 -19. .863 -11. .359 1. .00 32. .60 C

ATOM 2335 O SER B 110 -5. .649 -20. .103 -12. .549 1. .00 33. .55 0

ATOM 2336 CB SER B 110 -3. .584 -18. .814 -10. .888 1. .00 33. .02 c

ATOM 2337 OG SER B 110 -2. .917 -17. .845 -10. .100 1. .00 34. .62 0

HETATM 2338 N MSE B 111 -6. .444 -20. .663 -10. .547 1. .00 31. .53 N

HETATM 2339 CA MSE B 111 -6. .948 -21. .950 -11. .055 1. .00 33. .85 C

HETATM 2340 C MSE B 111 -8. .385 -21. .851 -11. .500 1. .00 35. .10 C

HETATM 2341 O MSE B 111 -9. .170 -21. .086 -10. .933 1. .00 36. .22 O

HETATM 2342 CB MSE B 111 -6. .738 -23. .037 -10. .001 1. .00 35. .06 c

HETATM 2343 CG MSE B 111 -5. .240 -23. .160 -9. .654 1. .00 36. .95 c

HETATM 2344 SE MSE B 111 -4. .829 -24. .799 -8. .624 1. .00 36. .73 SE

HETATM 2345 CE MSE B 111 -6. .679 -25. .439 -8. .549 1. .00 40. .18 C

ATOM 2346 N ASP B 112 -8. .735 -22. .604 -12. .540 1. .00 35. .96 N

ATOM 2347 CA ASP B 112 -10. .102 -22. .638 -13. .052 1. .00 37. .39 C

ATOM 2348 C ASP B 112 -11. .021 -23. .327 -12. .054 1. .00 34. .52 C

ATOM 2349 O ASP B 112 -10. .792 -24. .468 -11. .705 1. .00 36. .07 O

ATOM 2350 CB ASP B 112 -10. .158 -23. .391 -14. .389 1. .00 43. .10 C

ATOM 2351 CG ASP B 112 -9. .334 -22. .725 -15. .476 1. .00 47. .56 c

ATOM 2352 OD1 ASP B 112 -9. .295 -21. .476 -15. .515 1. .00 54. .94 0

ATOM 2353 OD2 ASP B 112 -8. .734 -23. .449 -16. .299 1. .00 48. .85 0

ATOM 2354 N GLY B 113 -12. .078 -22. .646 -11. .629 1. .00 33. .31 N

ATOM 2355 CA GLY B 113 -12. .946 -23. .155 -10. .551 1. .00 33. .37 C

ATOM 2356 C GLY B 113 -12. .451 -22. .671 -9. .192 1. .00 32. .22 C

ATOM 2357 O GLY B 113 -13. .059 -22. .948 -8. .160 1. .00 30. .37 O

ATOM 2358 N GLY B 114 -11. .343 -21. .926 -9. .207 1. .00 33. .80 N

ATOM 2359 CA GLY B 114 -10. .719 -21. .409 -7. .987 1. .00 34. .79 C

ATOM 2360 C GLY B 114 -11. .528 -20. .359 -7. .241 1. .00 35. .48 C

ATOM 2361 O GLY B 114 -12. .266 -19. .579 -7. .844 1. .00 36. .94 O

ATOM 2362 N PHE B 115 -11. .390 -20. .349 -5. .917 1. .00 34. .95 N

ATOM 2363 CA PHE B 115 -11. .992 -19. .321 -5. .066 1. .00 32. .36 C

ATOM 2364 C PHE B 115 -11. .122 -19. .097 -3. .840 1. .00 33. .37 C ATOM 2365 O PHE B 115 -10..420 -20..016 -3..392 1..00 32..11 O

ATOM 2366 CB PHE B 115 -13. .417 -19. .703 -4. .640 1. .00 31. .03 C

ATOM 2367 CG PHE B 115 -13. .535 -21. .070 -4. .008 1. .00 33. .81 C

ATOM 2368 CD1 PHE B 115 -13. .358 -21. .244 -2. .635 1. .00 33. .54 C

ATOM 2369 CD2 PHE B 115 -13. .871 -22. .181 -4. .777 1. .00 32. .69 C

ATOM 2370 CE1 PHE B 115 -13. .482 -22. .509 -2. .050 1. .00 34. .51 C

ATOM 2371 CE2 PHE B 115 -14. .003 -23. .440 -4. .196 1. .00 34. .28 C

ATOM 2372 CZ PHE B 115 -13. .806 -23. .610 -2. .829 1. .00 33. .89 C

ATOM 2373 N GLN B 116 -11. .163 -17. .880 -3. .303 1. .00 32. .82 N

ATOM 2374 CA GLN B 116 -10. .477 -17. .571 -2. .055 1. .00 32. .39 C

ATOM 2375 C GLN B 116 -11. .410 -17. .936 -0. .917 1. .00 31. .95 C

ATOM 2376 O GLN B 116 -12. .611 -18. .099 -1. .140 1. .00 32. .29 O

ATOM 2377 CB GLN B 116 -10. .019 -16. .119 -2. .023 1. .00 32. .05 C

ATOM 2378 CG GLN B 116 -8. .852 -15. .932 -2. .977 1. .00 36. .03 c

ATOM 2379 CD GLN B 116 -8. .045 -14. .687 -2. .719 1. .00 37. .49 c

ATOM 2380 OE1 GLN B 116 -8. .590 -13. .636 -2. .364 1. .00 40. .75 0

ATOM 2381 NE2 GLN B 116 -6. .737 -14. .790 -2. .912 1. .00 37. .56 N

ATOM 2382 N PHE B 117 -10. .860 -18. .161 0. .274 1. .00 29. .64 N

ATOM 2383 CA PHE B 117 -11. .667 -18. .757 1. .335 1. .00 28. .32 C

ATOM 2384 C PHE B 117 -12. .452 -17. .712 2. .084 1. .00 27. .26 C

ATOM 2385 O PHE B 117 -11. .969 -16. .609 2. .338 1. .00 26. .68 O

ATOM 2386 CB PHE B 117 -10. .835 -19. .594 2. .317 1. .00 28. .45 C

ATOM 2387 CG PHE B 117 -9. .994 -20. .635 1. .662 1. .00 28. .80 C

ATOM 2388 CD1 PHE B 117 -10. .511 -21. .428 0. .638 1. .00 28. .87 C

ATOM 2389 CD2 PHE B 117 -8. .677 -20. .819 2. .057 1. .00 27. .25 C

ATOM 2390 CE1 PHE B 117 -9. .722 -22. .380 0. .022 1. .00 28. .19 c

ATOM 2391 CE2 PHE B 117 -7. .891 -21. .767 1. .442 1. .00 26. .96 c

ATOM 2392 CZ PHE B 117 -8. .412 -22. .550 0. .430 1. .00 26. .99 c

ATOM 2393 N SER B 118 -13. .650 -18. .110 2. .471 1. .00 27. .01 N

ATOM 2394 CA SER B 118 -14. .625 -17. .228 3. .069 1. .00 28. .24 C

ATOM 2395 C SER B 118 -15. .150 -17. .813 4. .404 1. .00 26. .46 C

ATOM 2396 O SER B 118 -15. .210 -19. .041 4. .584 1. .00 26. .14 0

ATOM 2397 CB SER B 118 -15. .744 -17. .015 2. .036 1. .00 28. .98 c

ATOM 2398 OG SER B 118 -16. .946 -16. .637 2. .648 1. .00 35. .27 0

ATOM 2399 N TYR B 119 -15. .544 -16. .932 5. .326 1. .00 24. .97 N

ATOM 2400 CA TYR B 119 -15. .903 -17. .326 6. .690 1. .00 23. .17 C

ATOM 2401 C TYR B 119 -17. .141 -16. .603 7. .240 1. .00 23. .95 C

ATOM 2402 O TYR B 119 -17. .305 -15. .383 7. .053 1. .00 23. .99 O

ATOM 2403 CB TYR B 119 -14. .707 -17. .070 7. .629 1. .00 22. .42 c

ATOM 2404 CG TYR B 119 -13. .425 -17. .769 7. .207 1. .00 21. .77 c

ATOM 2405 CD1 TYR B 119 -12. .592 -17. .222 6. .212 1. .00 21. .77 c

ATOM 2406 CD2 TYR B 119 -13. .062 -18. .983 7. .775 1. .00 20. .57 c

ATOM 2407 CE1 TYR B 119 -11. .451 -17. .879 5. .793 1. .00 19. .93 c

ATOM 2408 CE2 TYR B 119 -11. .925 -19. .639 7. .378 1. .00 20. .16 c

ATOM 2409 CZ TYR B 119 -11. .114 -19. .089 6. .398 1. .00 20. .54 c

ATOM 2410 OH TYR B 119 -9. .958 -19. .759 6. .037 1. .00 19. .00 0

ATOM 2411 N GLY B 120 -17. .988 -17. .350 7. .957 1. .00 23. .80 N

ATOM 2412 CA GLY B 120 -19. .157 -16. .774 8. .635 1. .00 23. .70 c

ATOM 2413 C GLY B 120 -20. .466 -17. .027 7. .887 1. .00 24. .72 c

ATOM 2414 O GLY B 120 -20. .441 -17. .484 6. .742 1. .00 24. .78 0

ATOM 2415 N ASN B 121 -21. .592 -16. .724 8. .542 1. .00 23. .59 N

ATOM 2416 CA ASN B 121 -22. .946 -16. .985 8. .036 1. .00 24. .65 C

ATOM 2417 C ASN B 121 -23. .152 -16. .583 6. .559 1. .00 24. .79 C

ATOM 2418 O ASN B 121 -23. .092 -15. .405 6. .210 1. .00 23. .93 O

ATOM 2419 CB ASN B 121 -23. .990 -16. .247 8. .893 1. .00 25. .86 c

ATOM 2420 CG ASN B 121 -23. .968 -16. .654 10. .368 1. .00 27. .04 c

ATOM 2421 OD1 ASN B 121 -22. .906 -16. .807 11. .000 1. .00 25. .24 0

ATOM 2422 ND2 ASN B 121 -25. .162 -16. .813 10. .930 1. .00 27. .54 N

ATOM 2423 N PRO B 122 -23. .424 -17. .561 5. .690 1. .00 25. .45 N

ATOM 2424 CA PRO B 122 -23. .601 -17. .218 4. .274 1. .00 25. .03 C

ATOM 2425 C PRO B 122 -24. .772 -16. .272 4. .033 1. .00 23. .96 C ATOM 2426 O PRO B 122 -24..781 -15..576 3..036 1..00 24..42 O

ATOM 2427 CB PRO B 122 -23. .860 -18. .567 3. .597 1. .00 25. .49 C

ATOM 2428 CG PRO B 122 -23. .462 -19. .622 4. .598 1. .00 27. .06 C

ATOM 2429 CD PRO B 122 -23. .616 -18. .997 5. .960 1. .00 26. .44 C

ATOM 2430 N GLU B 123 -25. .748 -16. .229 4. .929 1. .00 23. .61 N

ATOM 2431 CA GLU B 123 -26. .876 -15. .309 4. .729 1. .00 24. .21 C

ATOM 2432 C GLU B 123 -26. .587 -13. .840 5. .049 1. .00 23. .30 C

ATOM 2433 O GLU B 123 -27. .400 -12. .963 4. .724 1. .00 23. .58 O

ATOM 2434 CB GLU B 123 -28. .140 -15. .794 5. .448 1. .00 25. .13 C

ATOM 2435 CG GLU B 123 -28. .183 -15. .553 6. .948 1. .00 29. .14 C

ATOM 2436 CD GLU B 123 -27. .365 -16. .558 7. .784 1. .00 29. .85 c

ATOM 2437 OE1 GLU B 123 -26. .669 -17. .448 7. .224 1. .00 28. .06 0

ATOM 2438 OE2 GLU B 123 -27. .429 -16. .443 9. .035 1. .00 30. .82 0

ATOM 2439 N LEU B 124 -25. .444 -13. .555 5. .673 1. .00 21. .68 N

ATOM 2440 CA LEU B 124 -25. .102 -12. .158 5. .984 1. .00 21. .96 C

ATOM 2441 C LEU B 124 -24. .348 -11. .467 4. .838 1. .00 21. .63 C

ATOM 2442 O LEU B 124 -23. .616 -12. .119 4. .081 1. .00 24. .19 O

ATOM 2443 CB LEU B 124 -24. .285 -12. .046 7. .279 1. .00 20. .22 c

ATOM 2444 CG LEU B 124 -25. .008 -12. .260 8. .610 1. .00 21. .48 c

ATOM 2445 CD1 LEU B 124 -23. .975 -12. .310 9. .740 1. .00 19. .98 c

ATOM 2446 CD2 LEU B 124 -26. .045 -11. .165 8. .868 1. .00 21. .37 c

ATOM 2447 N PRO B 125 -24. .496 -10. .147 4. .718 1. .00 21. .44 N

ATOM 2448 CA PRO B 125 -23. .664 -9. .458 3. .713 1. .00 23. .14 C

ATOM 2449 C PRO B 125 -22. .167 -9. .650 3. .951 1. .00 24. .90 C

ATOM 2450 O PRO B 125 -21. .682 -9. .618 5. .095 1. .00 23. .59 0

ATOM 2451 CB PRO B 125 -24. .028 -7. .982 3. .889 1. .00 22. .48 c

ATOM 2452 CG PRO B 125 -25. .323 -7. .962 4. .644 1. .00 21. .59 c

ATOM 2453 CD PRO B 125 -25. .372 -9. .224 5. .465 1. .00 21. .10 c

ATOM 2454 N GLU B 126 -21. .446 -9. .835 2. .857 1. .00 26. .15 N

ATOM 2455 CA GLU B 126 -20. .006 -9. .998 2. .879 1. .00 28. .25 C

ATOM 2456 C GLU B 126 -19. .298 -8. .881 3. .667 1. .00 27. .31 C

ATOM 2457 O GLU B 126 -18. .373 -9. .165 4. .434 1. .00 24. .83 0

ATOM 2458 CB GLU B 126 -19. .474 -10. .093 1. .439 1. .00 32. .37 c

ATOM 2459 CG GLU B 126 -17. .979 -9. .902 1. .280 1. .00 39. .30 c

ATOM 2460 CD GLU B 126 -17. .523 -9. .924 -0. .176 1. .00 47. .60 c

ATOM 2461 OE1 GLU B 126 -18. .376 -9. .927 -1. .095 1. .00 50. .29 0

ATOM 2462 OE2 GLU B 126 -16. .293 -9. .930 -0. .406 1. .00 51. .86 0

ATOM 2463 N ASP B 127 -19. .742 -7. .648 3. .491 1. .00 26. .66 N

ATOM 2464 CA ASP B 127 -19. .201 -6. .497 4. .199 1. .00 28. .33 C

ATOM 2465 C ASP B 127 -19. .392 -6. .609 5. .699 1. .00 25. .40 c

ATOM 2466 O ASP B 127 -18. .561 -6. .193 6. .439 1. .00 24. .84 0

ATOM 2467 CB ASP B 127 -19. .716 -5. .158 3. .640 1. .00 32. .48 c

ATOM 2468 CG ASP B 127 -21. .197 -4. .884 3. .959 1. .00 39. .31 c

ATOM 2469 OD1 ASP B 127 -22. .067 -5. .267 3. .171 1. .00 44. .06 0

ATOM 2470 OD2 ASP B 127 -21. .498 -4. .241 4. .973 1. .00 44. .51 0

ATOM 2471 N VAL B 128 -20. .509 -7. .169 6. .120 1. .00 22. .96 N

ATOM 2472 CA VAL B 128 -20. .822 -7. .343 7. .535 1. .00 21. .81 C

ATOM 2473 C VAL B 128 -19. .905 -8. .416 8. .132 1. .00 21. .08 C

ATOM 2474 O VAL B 128 -19. .366 -8. .243 9. .230 1. .00 21. .52 0

ATOM 2475 CB VAL B 128 -22. .315 -7. .691 7. .739 1. .00 22. .25 c

ATOM 2476 CGI VAL B 128 -22. .598 -8. .191 9. .145 1. .00 21. .05 c

ATOM 2477 CG2 VAL B 128 -23. .190 -6. .490 7. .403 1. .00 22. .39 c

ATOM 2478 N LEU B 129 -19. .700 -9. .502 7. .393 1. .00 20. .37 N

ATOM 2479 CA LEU B 129 -18. .831 -10. .591 7. .836 1. .00 20. .39 C

ATOM 2480 C LEU B 129 -17. .402 -10. .090 7. .949 1. .00 21. .14 C

ATOM 2481 O LEU B 129 -16. .690 -10. .429 8. .900 1. .00 18. .71 0

ATOM 2482 CB LEU B 129 -18. .917 -11. .797 6. .885 1. .00 19. .85 c

ATOM 2483 CG LEU B 129 -20. .250 -12. .571 6. .865 1. .00 20. .35 c

ATOM 2484 CD1 LEU B 129 -20. .292 -13. .606 5. .748 1. .00 19. .36 c

ATOM 2485 CD2 LEU B 129 -20. .516 -13. .240 8. .201 1. .00 20. .36 c

ATOM 2486 N AASP B 130 -17. .003 -9. .256 6. .990 0. .50 22. .05 N ATOM 2487 CA AASP B 130 -15..654 -8..708 6..980 0..50 25..08 C

ATOM 2488 C AASP B 130 -15. .398 -7. .874 8. .246 0. .50 23. .75 C

ATOM 2489 O AASP B 130 -14. .356 -8. .009 8. .871 0. .50 22. .82 O

ATOM 2490 CB AASP B 130 -15. .408 -7. .899 5. .703 0. .50 30. .33 C

ATOM 2491 CG AASP B 130 -13. .991 -7. .319 5. .639 0. .50 38. .08 C

ATOM 2492 OD1AASP B 130 -13. .036 -8. .075 5. .320 0. .50 43. .98 O

ATOM 2493 OD2AASP B 130 -13. .827 -6. .099 5. .904 0. .50 40. .43 O

ATOM 2494 N BASP B 130 -17. .006 -9. .223 7. .020 0. .50 22. .05 N

ATOM 2495 CA BASP B 130 -15. .671 -8. .653 6. .969 0. .50 25. .08 C

ATOM 2496 C BASP B 130 -15. .396 -7. .830 8. .216 0. .50 23. .75 C

ATOM 2497 O BASP B 130 -14. .422 -8. .027 8. .855 0. .50 22. .82 O

ATOM 2498 CB BASP B 130 -15. .511 -7. .705 5. .781 0. .50 30. .33 C

ATOM 2499 CG BASP B 130 -15. .259 -8. .403 4. .460 0. .50 38. .08 c

ATOM 2500 OD1BASP B 130 -14. .938 -9. .603 4. .415 0. .50 43. .98 0

ATOM 2501 OD2BASP B 130 -15. .354 -7. .716 3. .420 0. .50 40. .43 0

ATOM 2502 N VAL B 131 -16. .367 -7. .044 8. .636 1. .00 22. .84 N

ATOM 2503 CA VAL B 131 -16. .271 -6. .236 9. .857 1. .00 21. .38 C

ATOM 2504 C VAL B 131 -16. .290 -7. .114 11. .115 1. .00 21. .18 C

ATOM 2505 O VAL B 131 -15. .507 -6. .888 12. .039 1. .00 22. .17 O

ATOM 2506 CB VAL B 131 -17. .390 -5. .177 9. .905 1. .00 21. .79 c

ATOM 2507 CGI VAL B 131 -17. .524 -4. .553 11. .294 1. .00 20. .28 c

ATOM 2508 CG2 VAL B 131 -17. .140 -4. .106 8. .842 1. .00 22. .58 c

ATOM 2509 N GLN B 132 -17. .149 -8. .128 11. .147 1. .00 19. .68 N

ATOM 2510 CA GLN B 132 -17. .180 -9. .031 12. .298 1. .00 20. .05 C

ATOM 2511 C GLN B 132 -15. .842 -9. .752 12. .473 1. .00 20. .92 C

ATOM 2512 O GLN B 132 -15. .298 -9. .795 13. .579 1. .00 21. .04 O

ATOM 2513 CB GLN B 132 -18. .350 -10. .016 12. .223 1. .00 20. .19 c

ATOM 2514 CG GLN B 132 -19. .733 -9. .378 12. .331 1. .00 20. .31 c

ATOM 2515 CD GLN B 132 -20. .089 -8. .891 13. .725 1. .00 20. .80 c

ATOM 2516 OE1 GLN B 132 -19. .246 -8. .354 14. .454 1. .00 21. .23 0

ATOM 2517 NE2 GLN B 132 -21. .354 -9. .070 14. .106 1. .00 20. .06 N

ATOM 2518 N LEU B 133 -15. .288 -10. .277 11. .381 1. .00 20. .99 N

ATOM 2519 CA LEU B 133 -13. .947 -10. .853 11. .429 1. .00 21. .40 C

ATOM 2520 C LEU B 133 -12. .866 -9. .860 11. .806 1. .00 20. .29 C

ATOM 2521 O LEU B 133 -11. .934 -10. .223 12. .504 1. .00 20. .38 O

ATOM 2522 CB LEU B 133 -13. .584 -11. .546 10. .108 1. .00 22. .73 C

ATOM 2523 CG LEU B 133 -13. .928 -13. .030 10. .061 1. .00 25. .58 C

ATOM 2524 CD1 LEU B 133 -15. .405 -13. .286 10. .352 1. .00 25. .48 C

ATOM 2525 CD2 LEU B 133 -13. .616 -13. .524 8. .663 1. .00 30. .24 c

ATOM 2526 N ALA B 134 -13. .012 -8. .612 11. .363 1. .00 19. .27 N

ATOM 2527 CA ALA B 134 -12. .034 -7. .555 11. .608 1. .00 18. .68 C

ATOM 2528 C ALA B 134 -11. .929 -7. .238 13. .098 1. .00 18. .75 C

ATOM 2529 O ALA B 134 -10. .833 -7. .047 13. .624 1. .00 19. .15 O

ATOM 2530 CB ALA B 134 -12. .374 -6. .287 10. .803 1. .00 17. .90 c

ATOM 2531 N PHE B 135 -13. .068 -7. .194 13. .785 1. .00 19. .61 N

ATOM 2532 CA PHE B 135 -13. .074 -7. .007 15. .237 1. .00 18. .61 C

ATOM 2533 C PHE B 135 -12. .278 -8. .106 15. .915 1. .00 19. .35 C

ATOM 2534 O PHE B 135 -11. .471 -7. .822 16. .806 1. .00 21. .09 O

ATOM 2535 CB PHE B 135 -14. .490 -6. .951 15. .795 1. .00 17. .77 C

ATOM 2536 CG PHE B 135 -15. .024 -5. .554 15. .943 1. .00 18. .21 c

ATOM 2537 CD1 PHE B 135 -15. .596 -4. .891 14. .850 1. .00 18. .62 c

ATOM 2538 CD2 PHE B 135 -14. .940 -4. .888 17. .162 1. .00 18. .08 c

ATOM 2539 CE1 PHE B 135 -16. .083 -3. .602 14. .974 1. .00 18. .78 c

ATOM 2540 CE2 PHE B 135 -15. .435 -3. .603 17. .300 1. .00 19. .09 c

ATOM 2541 CZ PHE B 135 -16. .011 -2. .955 16. .201 1. .00 19. .54 c

ATOM 2542 N LEU B 136 -12. .476 -9. .353 15. .492 1. .00 19. .14 N

ATOM 2543 CA LEU B 136 -11. .735 -10. .469 16. .089 1. .00 19. .18 C

ATOM 2544 C LEU B 136 -10. .254 -10. .469 15. .701 1. .00 18. .88 c

ATOM 2545 O LEU B 136 -9. .383 -10. .753 16. .534 1. .00 19. .81 0

ATOM 2546 CB LEU B 136 -12. .392 -11. .819 15. .750 1. .00 19. .74 c

ATOM 2547 CG LEU B 136 -13. .777 -12. .073 16. .338 1. .00 18. .48 c ATOM 2548 CD1 LEU B 136 -14..421 -13..210 15..584 1..00 19..88 C

ATOM 2549 CD2 LEU B 136 -13. .657 -12. .421 17. .812 1. .00 18. .40 C

ATOM 2550 N ARG B 137 -9. .963 -10. .128 14. .449 1. .00 18. .49 N

ATOM 2551 CA ARG B 137 -8. .580 -10. .164 13. .948 1. .00 18. .30 C

ATOM 2552 C ARG B 137 -7. .734 -9. .081 14. .608 1. .00 18. .94 C

ATOM 2553 O ARG B 137 -6. .569 -9. .304 14. .981 1. .00 18. .51 O

ATOM 2554 CB ARG B 137 -8. .558 -10. .013 12. .425 1. .00 17. .97 C

ATOM 2555 CG ARG B 137 -9. .192 -11. .181 11. .671 1. .00 17. .81 c

ATOM 2556 CD ARG B 137 -9. .450 -10. .851 10. .205 1. .00 18. .92 c

ATOM 2557 NE ARG B 137 -8. .208 -10. .395 9. .596 1. .00 18. .81 N

ATOM 2558 CZ ARG B 137 -8. .024 -9. .206 9. .039 1. .00 19. .81 C

ATOM 2559 NH1 ARG B 137 -9. .025 -8. .341 8. .923 1. .00 20. .13 N

ATOM 2560 NH2 ARG B 137 -6. .828 -8. .889 8. .577 1. .00 20. .31 N

ATOM 2561 N LEU B 138 -8. .333 -7. .904 14. .775 1. .00 19. .23 N

ATOM 2562 CA LEU B 138 -7. .601 -6. .778 15. .324 1. .00 19. .76 C

ATOM 2563 C LEU B 138 -7. .481 -6. .797 16. .843 1. .00 18. .91 C

ATOM 2564 O LEU B 138 -6. .508 -6. .297 17. .365 1. .00 18. .29 O

ATOM 2565 CB LEU B 138 -8. .184 -5. .432 14. .859 1. .00 20. .33 C

ATOM 2566 CG LEU B 138 -7. .635 -4. .769 13. .587 1. .00 23. .50 C

ATOM 2567 CD1 LEU B 138 -6. .100 -4. .770 13. .571 1. .00 23. .37 C

ATOM 2568 CD2 LEU B 138 -8. .197 -5. .411 12. .316 1. .00 23. .72 C

ATOM 2569 N LEU B 139 -8. .472 -7. .350 17. .540 1. .00 18. .71 N

ATOM 2570 CA LEU B 139 -8. .588 -7. .160 18. .988 1. .00 19. .12 C

ATOM 2571 C LEU B 139 -8. .550 -8. .462 19. .828 1. .00 20. .03 C

ATOM 2572 O LEU B 139 -8. .928 -8. .454 20. .992 1. .00 20. .67 O

ATOM 2573 CB LEU B 139 -9. .850 -6. .325 19. .277 1. .00 19. .59 C

ATOM 2574 CG LEU B 139 -9. .772 -4. .903 18. .666 1. .00 19. .52 c

ATOM 2575 CD1 LEU B 139 -11. .146 -4. .275 18. .549 1. .00 20. .53 c

ATOM 2576 CD2 LEU B 139 -8. .838 -3. .985 19. .459 1. .00 18. .78 c

ATOM 2577 N SER B 140 -8. .106 -9. .571 19. .228 1. .00 20. .04 N

ATOM 2578 CA SER B 140 -7. .859 -10. .845 19. .949 1. .00 21. .04 C

ATOM 2579 C SER B 140 -6. .418 -10. .899 20. .415 1. .00 20. .81 C

ATOM 2580 O SER B 140 -5. .561 -10. .226 19. .842 1. .00 21. .93 O

ATOM 2581 CB SER B 140 -8. .093 -12. .050 19. .027 1. .00 21. .14 c

ATOM 2582 OG SER B 140 -9. .475 -12. .235 18. .767 1. .00 22. .35 0

ATOM 2583 N SER B 141 -6. .138 -11. .713 21. .426 1. .00 21. .71 N

ATOM 2584 CA SER B 141 -4. .762 -11. .888 21. .895 1. .00 23. .04 C

ATOM 2585 C SER B 141 -3. .967 -12. .812 20. .971 1. .00 23. .23 C

ATOM 2586 O SER B 141 -2. .764 -12. .667 20. .817 1. .00 23. .85 O

ATOM 2587 CB SER B 141 -4. .733 -12. .433 23. .320 1. .00 23. .96 c

ATOM 2588 OG SER B 141 -5. .165 -13. .779 23. .363 1. .00 26. .76 0

ATOM 2589 N ARG B 142 -4. .646 -13. .781 20. .374 1. .00 22. .77 N

ATOM 2590 CA ARG B 142 -3. .982 -14. .695 19. .462 1. .00 24. .45 C

ATOM 2591 C ARG B 142 -5. .019 -15. .390 18. .597 1. .00 22. .89 C

ATOM 2592 O ARG B 142 -6. .227 -15. .273 18. .863 1. .00 21. .02 O

ATOM 2593 CB ARG B 142 -3. .147 -15. .727 20. .226 1. .00 27. .64 c

ATOM 2594 CG ARG B 142 -3. .955 -16. .724 21. .032 1. .00 33. .81 c

ATOM 2595 CD ARG B 142 -3. .078 -17. .482 22. .013 1. .00 41. .05 c

ATOM 2596 NE ARG B 142 -2. .785 -16. .660 23. .189 1. .00 50. .79 N

ATOM 2597 CZ ARG B 142 -1. .568 -16. .322 23. .607 1. .00 53. .07 C

ATOM 2598 NH1 ARG B 142 -0. .475 -16. .737 22. .963 1. .00 53. .96 N

ATOM 2599 NH2 ARG B 142 -1. .452 -15. .571 24. .691 1. .00 53. .94 N

ATOM 2600 N ALA B 143 -4. .535 -16. .108 17. .582 1. .00 19. .52 N

ATOM 2601 CA ALA B 143 -5. .381 -16. .874 16. .687 1. .00 19. .65 C

ATOM 2602 C ALA B 143 -4. .604 -18. .027 16. .101 1. .00 19. .71 C

ATOM 2603 O ALA B 143 -3. .368 -17. .996 16. .066 1. .00 19. .77 O

ATOM 2604 CB ALA B 143 -5. .938 -15. .998 15. .568 1. .00 17. .90 C

ATOM 2605 N SER B 144 -5. .338 -19. .028 15. .617 1. .00 19. .26 N

ATOM 2606 CA SER B 144 -4. .745 -20. .193 14. .962 1. .00 19. .31 C

ATOM 2607 C SER B 144 -5. .741 -20. .797 13. .966 1. .00 18. .30 C

ATOM 2608 O SER B 144 -6. .943 -20. .585 14. .069 1. .00 18. .20 O ATOM 2609 CB SER B 144 -4..386 -21..246 15..993 1..00 18..80 C

ATOM 2610 OG SER B 144 -5. .592 -21. .805 16. .471 1. .00 20. .65 O

ATOM 2611 N GLN B 145 -5. .240 -21. .554 12. .999 1. .00 17. .97 N

ATOM 2612 CA GLN B 145 -6. .111 -22. .195 12. .030 1. .00 18. .32 C

ATOM 2613 C GLN B 145 -5. .328 -23. .334 11. .431 1. .00 18. .44 C

ATOM 2614 O GLN B 145 -4. .133 -23. .177 11. .155 1. .00 19. .17 O

ATOM 2615 CB GLN B 145 -6. .566 -21. .197 10. .924 1. .00 17. .26 C

ATOM 2616 CG GLN B 145 -7. .567 -21. .764 9. .909 1. .00 17. .21 c

ATOM 2617 CD GLN B 145 -7. .964 -20. .761 8. .820 1. .00 17. .77 c

ATOM 2618 OE1 GLN B 145 -7. .350 -19. .703 8. .665 1. .00 17. .53 0

ATOM 2619 NE2 GLN B 145 -9. .000 -21. .091 8. .065 1. .00 17. .34 N

ATOM 2620 N GLN B 146 -6. .007 -24. .459 11. .236 1. .00 17. .83 N

ATOM 2621 CA GLN B 146 -5. .472 -25. .605 10. .513 1. .00 19. .73 C

ATOM 2622 C GLN B 146 -6. .079 -25. .722 9. .113 1. .00 20. .38 C

ATOM 2623 O GLN B 146 -7. .252 -25. .381 8. .870 1. .00 20. .50 O

ATOM 2624 CB GLN B 146 -5. .739 -26. .921 11. .280 1. .00 19. .77 C

ATOM 2625 CG GLN B 146 -5. .067 -27. .011 12. .643 1. .00 21. .11 C

ATOM 2626 CD GLN B 146 -5. .433 -28. .277 13. .411 1. .00 22. .01 C

ATOM 2627 OE1 GLN B 146 -5. .872 -29. .272 12. .836 1. .00 22. .66 O

ATOM 2628 NE2 GLN B 146 -5. .249 -28. .236 14. .719 1. .00 22. .19 N

ATOM 2629 N ILE B 147 -5. .287 -26. .254 8. .195 1. .00 21. .08 N

ATOM 2630 CA ILE B 147 -5. .761 -26. .533 6. .860 1. .00 22. .04 C

ATOM 2631 C ILE B 147 -5. .174 -27. .888 6. .469 1. .00 22. .06 C

ATOM 2632 O ILE B 147 -4. .038 -28. .186 6. .818 1. .00 22. .16 O

ATOM 2633 CB ILE B 147 -5. .417 -25. .349 5. .918 1. .00 22. .90 C

ATOM 2634 CGI ILE B 147 -5. .968 -25. .563 4. .514 1. .00 24. .19 C

ATOM 2635 CG2 ILE B 147 -3. .919 -25. .070 5. .894 1. .00 23. .32 C

ATOM 2636 CD1 ILE B 147 -6. .245 -24. .253 3. .782 1. .00 25. .68 C

ATOM 2637 N THR B 148 -5. .985 -28. .735 5. .834 1. .00 23. .07 N

ATOM 2638 CA THR B 148 -5. .577 -30. .074 5. .403 1. .00 23. .59 C

ATOM 2639 C THR B 148 -5. .509 -30. .154 3. .893 1. .00 24. .14 C

ATOM 2640 O THR B 148 -6. .491 -29. .866 3. .214 1. .00 23. .38 O

ATOM 2641 CB THR B 148 -6. .587 -31. .135 5. .850 1. .00 23. .93 C

ATOM 2642 OG1 THR B 148 -6. .809 -30. .995 7. .241 1. .00 25. .06 0

ATOM 2643 CG2 THR B 148 -6. .064 -32. .571 5. .595 1. .00 24. .48 c

ATOM 2644 N TYR B 149 -4. .342 -30. .537 3. .377 1. .00 24. .47 N

ATOM 2645 CA TYR B 149 -4. .135 -30. .750 1. .941 1. .00 23. .90 C

ATOM 2646 C TYR B 149 -4. .273 -32. .252 1. .662 1. .00 25. .28 C

ATOM 2647 O TYR B 149 -3. .535 -33. .059 2. .231 1. .00 25. .13 O

ATOM 2648 CB TYR B 149 -2. .733 -30. .249 1. .579 1. .00 23. .70 c

ATOM 2649 CG TYR B 149 -2. .319 -30. .269 0. .107 1. .00 23. .95 c

ATOM 2650 CD1 TYR B 149 -2. .727 -29. .259 -0. .763 1. .00 23. .93 c

ATOM 2651 CD2 TYR B 149 -1. .475 -31. .272 -0. .395 1. .00 23. .17 c

ATOM 2652 CE1 TYR B 149 -2. .324 -29. .249 -2. .091 1. .00 23. .99 c

ATOM 2653 CE2 TYR B 149 -1. .052 -31. .275 -1. .720 1. .00 23. .32 c

ATOM 2654 CZ TYR B 149 -1. .489 -30. .260 -2. .576 1. .00 24. .95 c

ATOM 2655 OH TYR B 149 -1. .103 -30. .228 -3. .905 1. .00 23. .53 0

ATOM 2656 N HIS B 150 -5. .239 -32. .622 0. .820 1. .00 25. .86 N

ATOM 2657 CA HIS B 150 -5. .374 -33. .997 0. .329 1. .00 26. .21 c

ATOM 2658 C HIS B 150 -4. .577 -34. .133 -0. .941 1. .00 26. .59 c

ATOM 2659 O HIS B 150 -4. .714 -33. .322 -1. .852 1. .00 25. .68 0

ATOM 2660 CB HIS B 150 -6. .830 -34. .360 0. .101 1. .00 26. .21 c

ATOM 2661 CG HIS B 150 -7. .659 -34. .317 1. .350 1. .00 27. .35 c

ATOM 2662 ND1 HIS B 150 -7. .823 -35. .387 2. .145 1. .00 29. .22 N

ATOM 2663 CD2 HIS B 150 -8. .345 -33. .263 1. .963 1. .00 28. .79 C

ATOM 2664 CE1 HIS B 150 -8. .599 -35. .059 3. .200 1. .00 28. .41 C

ATOM 2665 NE2 HIS B 150 -8. .915 -33. .754 3. .087 1. .00 30. .92 N

ATOM 2666 N CYS B 151 -3. .725 -35. .152 -0. .997 1. .00 25. .14 N

ATOM 2667 CA CYS B 151 -2. .719 -35. .255 -2. .039 1. .00 25. .49 C

ATOM 2668 C CYS B 151 -2. .788 -36. .610 -2. .734 1. .00 27. .46 C

ATOM 2669 O CYS B 151 -2. .893 -37. .642 -2. .073 1. .00 26. .89 O ATOM 2670 CB CYS B 151 -1..322 -35..093 -1..426 1..00 23..98 C

ATOM 2671 SG CYS B 151 -1. .073 -36. .240 -0. .046 1. .00 23. .87 S

ATOM 2672 N LYS B 152 -2. .727 -36. .585 -4. .064 1. .00 29. .95 N

ATOM 2673 CA LYS B 152 -2. .378 -37. .767 -4. .872 1. .00 32. .62 C

ATOM 2674 C LYS B 152 -1. .222 -37. .374 -5. .793 1. .00 32. .41 C

ATOM 2675 O LYS B 152 -1. .361 -36. .500 -6. .656 1. .00 30. .94 O

ATOM 2676 CB LYS B 152 -3. .589 -38. .228 -5. .683 1. .00 36. .80 C

ATOM 2677 CG LYS B 152 -3. .377 -39. .398 -6. .645 1. .00 39. .10 c

ATOM 2678 CD LYS B 152 -4. .670 -39. .645 -7. .435 1. .00 40. .95 c

ATOM 2679 CE LYS B 152 -4. .565 -40. .862 -8. .337 1. .00 44. .58 c

ATOM 2680 NZ LYS B 152 -5. .910 -41. .309 -8. .792 1. .00 45. .58 N

ATOM 2681 N ASN B 153 -0. .074 -38. .003 -5. .589 1. .00 32. .67 N

ATOM 2682 CA ASN B 153 1. .146 -37. .676 -6. .325 1. .00 34. .41 C

ATOM 2683 C ASN B 153 1. .498 -36. .202 -6. .260 1. .00 35. .81 C

ATOM 2684 O ASN B 153 1. .771 -35. .572 -7. .291 1. .00 38. .09 O

ATOM 2685 CB ASN B 153 1. .062 -38. .137 -7. .781 1. .00 34. .32 C

ATOM 2686 CG ASN B 153 0. .619 -39. .578 -7. .902 1. .00 34. .57 C

ATOM 2687 OD1 ASN B 153 -0. .328 -39. .881 -8. .621 1. .00 37. .99 O

ATOM 2688 ND2 ASN B 153 1. .283 -40. .469 -7. .187 1. .00 32. .15 N

ATOM 2689 N SER B 154 1. .497 -35. .665 -5. .040 1. .00 33. .69 N

ATOM 2690 CA SER B 154 1. .804 -34. .264 -4. .805 1. .00 31. .47 C

ATOM 2691 C SER B 154 2. .427 -34. .075 -3. .425 1. .00 30. .13 C

ATOM 2692 O SER B 154 1. .770 -34. .262 -2. .413 1. .00 29. .66 O

ATOM 2693 CB SER B 154 0. .533 -33. .406 -4. .950 1. .00 30. .82 C

ATOM 2694 OG SER B 154 0. .840 -32. .015 -4. .848 1. .00 29. .21 O

ATOM 2695 N ILE B 155 3. .707 -33. .723 -3. .401 1. .00 29. .89 N

ATOM 2696 CA ILE B 155 4. .389 -33. .314 -2. .182 1. .00 28. .76 C

ATOM 2697 C ILE B 155 3. .671 -32. .072 -1. .645 1. .00 28. .71 C

ATOM 2698 O ILE B 155 3. .313 -31. .167 -2. .424 1. .00 26. .92 O

ATOM 2699 CB ILE B 155 5. .859 -32. .970 -2. .466 1. .00 29. .95 C

ATOM 2700 CGI ILE B 155 6. .564 -34. .102 -3. .252 1. .00 33. .95 c

ATOM 2701 CG2 ILE B 155 6. .612 -32. .643 -1. .189 1. .00 31. .11 c

ATOM 2702 CD1 ILE B 155 6. .543 -35. .476 -2. .594 1. .00 32. .84 c

ATOM 2703 N ALA B 156 3. .430 -32. .062 -0. .334 1. .00 24. .19 N

ATOM 2704 CA ALA B 156 2. .735 -30. .972 0. .335 1. .00 25. .59 C

ATOM 2705 C ALA B 156 3. .732 -30. .220 1. .168 1. .00 24. .58 C

ATOM 2706 O ALA B 156 3. .657 -28. .995 1. .318 1. .00 25. .07 O

ATOM 2707 CB ALA B 156 1. .625 -31. .509 1. .221 1. .00 24. .06 c

ATOM 2708 N TYR B 157 4. .695 -30. .957 1. .700 1. .00 23. .64 N

ATOM 2709 CA TYR B 157 5. .662 -30. .352 2. .581 1. .00 23. .17 C

ATOM 2710 C TYR B 157 7. .057 -30. .941 2. .365 1. .00 24. .84 C

ATOM 2711 O TYR B 157 7. .924 -30. .303 1. .754 1. .00 24. .25 O

ATOM 2712 CB TYR B 157 5. .182 -30. .466 4. .024 1. .00 21. .01 c

ATOM 2713 CG TYR B 157 6. .132 -29. .911 5. .045 1. .00 21. .73 c

ATOM 2714 CD1 TYR B 157 6. .448 -28. .546 5. .076 1. .00 20. .28 c

ATOM 2715 CD2 TYR B 157 6. .706 -30. .753 6. .003 1. .00 20. .76 c

ATOM 2716 CE1 TYR B 157 7. .329 -28. .046 6. .024 1. .00 20. .54 c

ATOM 2717 CE2 TYR B 157 7. .562 -30. .258 6. .959 1. .00 20. .44 c

ATOM 2718 CZ TYR B 157 7. .867 -28. .916 6. .967 1. .00 21. .10 c

ATOM 2719 OH TYR B 157 8. .740 -28. .470 7. .914 1. .00 22. .33 0

HETATM 2720 N MSE B 158 7. .259 -32. .160 2. .845 1. .00 25. .66 N

HETATM 2721 CA MSE B 158 8. .565 -32. .780 2. .783 1. .00 27. .03 C

HETATM 2722 C MSE B 158 8. .544 -33. .706 1. .592 1. .00 26. .33 c

HETATM 2723 O MSE B 158 7. .558 -34. .383 1. .320 1. .00 22. .68 0

HETATM 2724 CB MSE B 158 8. .766 -33. .463 4. .135 1. .00 30. .85 c

HETATM 2725 CG MSE B 158 9. .727 -34. .637 4. .146 1. .00 38. .64 c

HETATM 2726 SE MSE B 158 11. .487 -33. .955 4. .676 1. .00 54. .87 SE

HETATM 2727 CE MSE B 158 11. .201 -33. .367 6. .535 1. .00 49. .26 C

ATOM 2728 N ASP B 159 9. .647 -33. .782 0. .888 1. .00 26. .49 N

ATOM 2729 CA ASP B 159 9. .793 -34. .760 -0. .152 1. .00 28. .55 C

ATOM 2730 C ASP B 159 10. .692 -35. .897 0. .351 1. .00 27. .61 C ATOM 2731 O ASP B 159 11..782 -35..646 0..801 1..00 26..75 O

ATOM 2732 CB ASP B 159 10. .378 -34. .080 -1. .378 1. .00 30. .23 C

ATOM 2733 CG ASP B 159 10. .915 -35. .040 -2. .360 1. .00 31. .58 C

ATOM 2734 OD1 ASP B 159 10. .158 -35. .599 -3. .127 1. .00 33. .66 O

ATOM 2735 OD2 ASP B 159 12. .104 -35. .267 -2. .344 1. .00 37. .30 O

ATOM 2736 N GLN B 160 10. .186 -37. .099 0. .336 1. .00 28. .35 N

ATOM 2737 CA GLN B 160 10. .951 -38. .182 0. .879 1. .00 32. .30 C

ATOM 2738 C GLN B 160 12. .270 -38. .435 0. .137 1. .00 31. .65 C

ATOM 2739 O GLN B 160 13. .265 -38. .684 0. .757 1. .00 31. .08 O

ATOM 2740 CB GLN B 160 10. .112 -39. .437 0. .970 1. .00 20. .00 C

ATOM 2741 CG GLN B 160 10. .861 -40. .612 1. .542 1. .00 20. .00 c

ATOM 2742 CD GLN B 160 10. .913 -41. .753 0. .570 1. .00 20. .00 c

ATOM 2743 OE1 GLN B 160 10. .107 -42. .659 0. .652 1. .00 20. .00 0

ATOM 2744 NE2 GLN B 160 11. .839 -41. .702 -0. .372 1. .00 20. .00 N

ATOM 2745 N ALA B 161 12. .258 -38. .349 -1. .181 1. .00 30. .96 N

ATOM 2746 CA ALA B 161 13. .462 -38. .586 -1. .966 1. .00 30. .28 C

ATOM 2747 C ALA B 161 14. .612 -37. .663 -1. .569 1. .00 30. .69 C

ATOM 2748 O ALA B 161 15. .766 -38. .088 -1. .519 1. .00 29. .91 O

ATOM 2749 CB ALA B 161 13. .160 -38. .447 -3. .451 1. .00 27. .61 C

ATOM 2750 N SER B 162 14. .296 -36. .401 -1. .297 1. .00 29. .14 N

ATOM 2751 CA SER B 162 15. .325 -35. .410 -1. .035 1. .00 27. .77 C

ATOM 2752 C SER B 162 15. .556 -35. .159 0. .436 1. .00 27. .72 C

ATOM 2753 O SER B 162 16. .598 -34. .629 0. .819 1. .00 26. .61 O

ATOM 2754 CB SER B 162 14. .984 -34. .083 -1. .719 1. .00 28. .79 C

ATOM 2755 OG SER B 162 13. .966 -33. .392 -1. .017 1. .00 29. .82 0

ATOM 2756 N GLY B 163 14. .571 -35. .503 1. .261 1. .00 28. .57 N

ATOM 2757 CA GLY B 163 14. .606 -35. .110 2. .675 1. .00 27. .67 C

ATOM 2758 C GLY B 163 14. .437 -33. .613 2. .922 1. .00 28. .54 C

ATOM 2759 O GLY B 163 14. .659 -33. .138 4. .037 1. .00 28. .63 O

ATOM 2760 N ASN B 164 14. .043 -32. .845 1. .908 1. .00 26. .81 N

ATOM 2761 CA ASN B 164 13. .885 -31. .410 2. .143 1. .00 26. .29 C

ATOM 2762 C ASN B 164 12. .493 -30. .896 1. .802 1. .00 24. .73 C

ATOM 2763 O ASN B 164 11. .649 -31. .647 1. .301 1. .00 22. .62 O

ATOM 2764 CB ASN B 164 15. .016 -30. .575 1. .485 1. .00 28. .21 C

ATOM 2765 CG ASN B 164 14. .854 -30. .432 -0. .028 1. .00 29. .49 c

ATOM 2766 OD1 ASN B 164 13. .754 -30. .239 -0. .546 1. .00 28. .39 0

ATOM 2767 ND2 ASN B 164 15. .970 -30. .528 -0. .742 1. .00 30. .44 N

ATOM 2768 N VAL B 165 12. .265 -29. .614 2. .102 1. .00 24. .40 N

ATOM 2769 CA VAL B 165 10. .942 -28. .997 2. .004 1. .00 23. .66 C

ATOM 2770 C VAL B 165 10. .885 -27. .901 0. .922 1. .00 24. .36 C

ATOM 2771 O VAL B 165 10. .060 -26. .979 0. .996 1. .00 22. .57 O

ATOM 2772 CB VAL B 165 10. .458 -28. .447 3. .376 1. .00 22. .32 C

ATOM 2773 CGI VAL B 165 10. .297 -29. .584 4. .374 1. .00 22. .20 C

ATOM 2774 CG2 VAL B 165 11. .400 -27. .376 3. .919 1. .00 20. .55 C

ATOM 2775 N LYS B 166 11. .736 -28. .024 -0. .099 1. .00 23. .78 N

ATOM 2776 CA LYS B 166 11. .812 -26. .988 -1. .137 1. .00 24. .25 C

ATOM 2777 C LYS B 166 10. .579 -27. .007 -2. .013 1. .00 23. .51 C

ATOM 2778 O LYS B 166 10. .266 -26. .013 -2. .641 1. .00 24. .31 O

ATOM 2779 CB LYS B 166 13. .088 -27. .107 -2. .008 1. .00 25. .54 C

ATOM 2780 CG LYS B 166 14. .402 -26. .925 -1. .266 1. .00 25. .86 c

ATOM 2781 CD LYS B 166 14. .516 -25. .552 -0. .635 1. .00 28. .38 c

ATOM 2782 CE LYS B 166 15. .904 -25. .380 -0. .024 1. .00 32. .68 c

ATOM 2783 NZ LYS B 166 15. .928 -24. .302 1. .001 1. .00 35. .36 N

ATOM 2784 N LYS B 167 9. .874 -28. .129 -2. .041 1. .00 23. .35 N

ATOM 2785 CA LYS B 167 8. .628 -28. .229 -2. .798 1. .00 23. .90 C

ATOM 2786 C LYS B 167 7. .357 -27. .979 -1. .967 1. .00 24. .20 C

ATOM 2787 O LYS B 167 6. .251 -28. .254 -2. .437 1. .00 25. .14 O

ATOM 2788 CB LYS B 167 8. .531 -29. .597 -3. .441 1. .00 25. .22 C

ATOM 2789 CG LYS B 167 9. .664 -29. .929 -4. .408 1. .00 27. .79 C

ATOM 2790 CD LYS B 167 9. .629 -31. .425 -4. .712 1. .00 31. .17 C

ATOM 2791 CE LYS B 167 10. .338 -31. .783 -6. .007 1. .00 32. .86 C ATOM 2792 NZ LYS B 167 10..092 -33..229 -6..260 1..00 36..98 N

ATOM 2793 N ALA B 168 7. .499 -27. .463 -0. .746 1. .00 23. .62 N

ATOM 2794 CA ALA B 168 6. .327 -27. .266 0. .139 1. .00 22. .83 C

ATOM 2795 C ALA B 168 5. .402 -26. .183 -0. .389 1. .00 22. .66 C

ATOM 2796 O ALA B 168 5. .868 -25. .192 -0. .941 1. .00 23. .93 O

ATOM 2797 CB ALA B 168 6. .778 -26. .918 1. .543 1. .00 21. .73 C

ATOM 2798 N LEU B 169 4. .100 -26. .377 -0. .206 1. .00 22. .15 N

ATOM 2799 CA LEU B 169 3. .099 -25. .385 -0. .542 1. .00 21. .50 C

ATOM 2800 C LEU B 169 3. .178 -24. .131 0. .341 1. .00 22. .83 C

ATOM 2801 O LEU B 169 3. .885 -24. .109 1. .362 1. .00 22. .38 O

ATOM 2802 CB LEU B 169 1. .708 -26. .009 -0. .479 1. .00 20. .99 C

ATOM 2803 CG LEU B 169 1. .163 -26. .558 0. .862 1. .00 20. .40 C

ATOM 2804 CD1 LEU B 169 0. .550 -25. .452 1. .715 1. .00 20. .08 c

ATOM 2805 CD2 LEU B 169 0. .124 -27. .641 0. .602 1. .00 18. .28 c

ATOM 2806 N LYS B 170 2. .458 -23. .091 -0. .084 1. .00 24. .09 N

ATOM 2807 CA LYS B 170 2. .318 -21. .817 0. .653 1. .00 24. .71 C

ATOM 2808 C LYS B 170 0. .852 -21. .552 0. .971 1. .00 23. .61 C

ATOM 2809 O LYS B 170 -0. .059 -22. .037 0. .283 1. .00 23. .76 O

ATOM 2810 CB LYS B 170 2. .785 -20. .620 -0. .189 1. .00 26. .14 c

ATOM 2811 CG LYS B 170 4. .253 -20. .599 -0. .550 1. .00 31. .05 c

ATOM 2812 CD LYS B 170 4. .692 -19. .233 -1. .085 1. .00 32. .42 c

ATOM 2813 CE LYS B 170 4. .135 -18. .878 -2. .465 1. .00 32. .13 c

ATOM 2814 NZ LYS B 170 4. .811 -17. .629 -2. .941 1. .00 30. .94 N

ATOM 2815 N LEU B 171 0. .633 -20. .733 1. .988 1. .00 22. .75 N

ATOM 2816 CA LEU B 171 -0. .713 -20. .307 2. .355 1. .00 22. .79 C

ATOM 2817 C LEU B 171 -0. .717 -18. .783 2. .333 1. .00 22. .38 C

ATOM 2818 O LEU B 171 0. .283 -18. .169 2. .657 1. .00 24. .24 O

ATOM 2819 CB LEU B 171 -1. .059 -20. .828 3. .761 1. .00 20. .55 C

ATOM 2820 CG LEU B 171 -0. .926 -22. .333 4. .021 1. .00 20. .00 C

ATOM 2821 CD1 LEU B 171 -0. .944 -22. .624 5. .520 1. .00 19. .39 C

ATOM 2822 CD2 LEU B 171 -2. .040 -23. .089 3. .316 1. .00 19. .41 c

HETATM 2823 N AMSE B 172 -1. .839 -18. .183 1. .955 0. .50 23. .16 N

HETATM 2824 CA AMSE B 172 -1. .971 -16. .730 1. .958 0. .50 24. .07 C

HETATM 2825 C AMSE B 172 -2. .774 -16. .304 3. .155 0. .50 23. .72 C

HETATM 2826 O AMSE B 172 -3. .897 -16. .758 3. .350 0. .50 23. .31 O

HETATM 2827 CB AMSE B 172 -2. .710 -16. .288 0. .705 0. .50 25. .84 C

HETATM 2828 CG AMSE B 172 -2. .719 -14. .767 0. .569 0. .50 27. .75 c

HETATM 2829 SE AMSE B 172 -3. .691 -14. .254 -1. .073 0. .50 33. .70 SE

HETATM 2830 CE AMSE B 172 -2. .396 -14. .868 -2. .424 0. .50 30. .81 C

HETATM 2831 N BMSE B 172 -1. .834 -18. .179 1. .945 0. .50 23. .41 N

HETATM 2832 CA BMSE B 172 -1. .952 -16. .725 1. .966 0. .50 24. .51 C

HETATM 2833 C BMSE B 172 -2. .767 -16. .308 3. .156 0. .50 24. .00 C

HETATM 2834 O BMSE B 172 -3. .888 -16. .769 3. .345 0. .50 23. .55 O

HETATM 2835 CB BMSE B 172 -2. .651 -16. .217 0. .716 0. .50 26. .88 C

HETATM 2836 CG BMSE B 172 -2. .794 -14. .697 0. .766 0. .50 29. .34 c

HETATM 2837 SE BMSE B 172 -1. .055 -13. .849 0. .390 0. .50 37. .23 SE

HETATM 2838 CE BMSE B 172 -1. .639 -11. .984 0. .110 0. .50 34. .29 C

ATOM 2839 N GLY B 173 -2. .206 -15. .426 3. .972 1. .00 24. .07 N

ATOM 2840 CA GLY B 173 -2. .933 -14. .867 5. .100 1. .00 24. .84 C

ATOM 2841 C GLY B 173 -3. .780 -13. .670 4. .717 1. .00 26. .04 C

ATOM 2842 O GLY B 173 -3. .983 -13. .387 3. .550 1. .00 26. .62 O

ATOM 2843 N SER B 174 -4. .256 -12. .956 5. .722 1. .00 26. .75 N

ATOM 2844 CA SER B 174 -5. .241 -11. .918 5. .541 1. .00 27. .03 C

ATOM 2845 C SER B 174 -4. .653 -10. .529 5. .638 1. .00 29. .58 C

ATOM 2846 O SER B 174 -5. .379 -9. .549 5. .503 1. .00 30. .56 O

ATOM 2847 CB SER B 174 -6. .330 -12. .054 6. .618 1. .00 25. .02 C

ATOM 2848 OG SER B 174 -7. .282 -13. .028 6. .260 1. .00 23. .72 0

ATOM 2849 N ASN B 175 -3. .363 -10. .431 5. .917 1. .00 32. .09 N

ATOM 2850 CA ASN B 175 -2. .711 -9. .128 6. .025 1. .00 37. .02 C

ATOM 2851 C ASN B 175 -1. .665 -9. .019 4. .930 1. .00 39. .52 C

ATOM 2852 O ASN B 175 -0. .546 -8. .546 5. .164 1. .00 39. .27 O ATOM 2853 CB ASN B 175 -2..071 -8..931 7..416 1..00 37..92 C

ATOM 2854 CG ASN B 175 -1. .910 -7. .455 7. .797 1. .00 39. .72 C

ATOM 2855 OD1 ASN B 175 -2. .773 -6. .620 7. .492 1. .00 37. .64 O

ATOM 2856 ND2 ASN B 175 -0. .808 -7. .133 8. .487 1. .00 36. .83 N

ATOM 2857 N GLU B 176 -2. .035 -9. .487 3. .737 1. .00 41. .13 N

ATOM 2858 CA GLU B 176 -1. .152 -9. .444 2. .568 1. .00 46. .44 C

ATOM 2859 C GLU B 176 0. .144 -10. .281 2. .747 1. .00 49. .31 C

ATOM 2860 O GLU B 176 1. .150 -10. .046 2. .057 1. .00 50. .95 O

ATOM 2861 CB GLU B 176 -0. .826 -7. .983 2. .203 1. .00 50. .04 C

ATOM 2862 CG GLU B 176 -2. .043 -7. .058 2. .210 1. .00 55. .29 C

ATOM 2863 CD GLU B 176 -1. .777 -5. .706 1. .563 1. .00 58. .61 C

ATOM 2864 OE1 GLU B 176 -0. .912 -4. .944 2. .062 1. .00 58. .56 O

ATOM 2865 OE2 GLU B 176 -2. .448 -5. .405 0. .555 1. .00 57. .53 O

ATOM 2866 N GLY B 177 0. .108 -11. .254 3. .664 1. .00 43. .44 N

ATOM 2867 CA GLY B 177 1. .274 -12. .075 3. .988 1. .00 38. .78 C

ATOM 2868 C GLY B 177 1. .106 -13. .535 3. .590 1. .00 36. .85 C

ATOM 2869 O GLY B 177 -0. .010 -14. .027 3. .427 1. .00 39. .90 O

ATOM 2870 N GLU B 178 2. .227 -14. .224 3. .421 1. .00 32. .29 N

ATOM 2871 CA GLU B 178 2. .232 -15. .639 3. .083 1. .00 30. .90 C

ATOM 2872 C GLU B 178 2. .868 -16. .438 4. .211 1. .00 27. .50 C

ATOM 2873 O GLU B 178 3. .825 -15. .992 4. .825 1. .00 26. .71 O

ATOM 2874 CB GLU B 178 3. .033 -15. .886 1. .798 1. .00 32. .09 C

ATOM 2875 CG GLU B 178 2. .578 -15. .058 0. .607 1. .00 34. .22 c

ATOM 2876 CD GLU B 178 3. .435 -15. .264 -0. .621 1. .00 34. .06 c

ATOM 2877 OE1 GLU B 178 4. .440 -16. .006 -0. .561 1. .00 34. .92 0

ATOM 2878 OE2 GLU B 178 3. .101 -14. .671 -1. .657 1. .00 35. .87 0

ATOM 2879 N PHE B 179 2. .338 -17. .629 4. .454 1. .00 25. .35 N

ATOM 2880 CA PHE B 179 2. .913 -18. .558 5. .421 1. .00 23. .77 C

ATOM 2881 C PHE B 179 3. .620 -19. .664 4. .657 1. .00 23. .58 C

ATOM 2882 O PHE B 179 3. .048 -20. .252 3. .730 1. .00 22. .92 0

ATOM 2883 CB PHE B 179 1. .813 -19. .118 6. .322 1. .00 21. .25 c

ATOM 2884 CG PHE B 179 0. .873 -18. .072 6. .841 1. .00 20. .42 c

ATOM 2885 CD1 PHE B 179 1. .359 -16. .845 7. .307 1. .00 20. .77 c

ATOM 2886 CD2 PHE B 179 -0. .505 -18. .299 6. .864 1. .00 19. .27 c

ATOM 2887 CE1 PHE B 179 0. .484 -15. .874 7. .780 1. .00 20. .30 c

ATOM 2888 CE2 PHE B 179 -1. .381 -17. .336 7. .348 1. .00 20. .06 c

ATOM 2889 CZ PHE B 179 -0. .886 -16. .123 7. .801 1. .00 20. .27 c

ATOM 2890 N LYS B 180 4. .867 -19. .924 5. .027 1. .00 24. .24 N

ATOM 2891 CA LYS B 180 5. .748 -20. .787 4. .227 1. .00 25. .07 C

ATOM 2892 C LYS B 180 6. .413 -21. .858 5. .078 1. .00 25. .09 c

ATOM 2893 O LYS B 180 6. .412 -21. .765 6. .314 1. .00 22. .67 0

ATOM 2894 CB LYS B 180 6. .867 -19. .952 3. .598 1. .00 25. .45 c

ATOM 2895 CG LYS B 180 6. .441 -18. .912 2. .567 1. .00 29. .34 c

ATOM 2896 CD LYS B 180 7. .674 -18. .452 1. .802 1. .00 31. .29 c

ATOM 2897 CE LYS B 180 7. .352 -17. .406 0. .759 1. .00 36. .91 c

ATOM 2898 NZ LYS B 180 7. .356 -16. .042 1. .359 1. .00 40. .93 N

ATOM 2899 N ALA B 181 7. .051 -22. .829 4. .417 1. .00 24. .55 N

ATOM 2900 CA ALA B 181 7. .829 -23. .826 5. .147 1. .00 25. .86 C

ATOM 2901 C ALA B 181 9. .046 -23. .208 5. .801 1. .00 25. .86 C

ATOM 2902 O ALA B 181 9. .436 -23. .611 6. .878 1. .00 25. .50 O

ATOM 2903 CB ALA B 181 8. .249 -24. .972 4. .245 1. .00 25. .75 C

ATOM 2904 N GLU B 182 9. .656 -22. .233 5. .139 1. .00 27. .57 N

ATOM 2905 CA GLU B 182 10. .913 -21. .652 5. .615 1. .00 29. .74 C

ATOM 2906 C GLU B 182 10. .886 -20. .141 5. .446 1. .00 30. .72 C

ATOM 2907 O GLU B 182 9. .907 -19. .582 4. .958 1. .00 30. .56 O

ATOM 2908 CB GLU B 182 12. .097 -22. .237 4. .837 1. .00 31. .50 C

ATOM 2909 CG GLU B 182 12. .046 -23. .750 4. .637 1. .00 31. .15 c

ATOM 2910 CD GLU B 182 13. .296 -24. .281 3. .948 1. .00 32. .65 c

ATOM 2911 OE1 GLU B 182 14. .312 -24. .441 4. .646 1. .00 35. .10 0

ATOM 2912 OE2 GLU B 182 13. .276 -24. .534 2. .719 1. .00 31. .69 0

ATOM 2913 N GLY B 183 11. .972 -19. .488 5. .838 1. .00 32. .71 N ATOM 2914 CA GLY B 183 12..074 -18..029 5..776 1..00 30..95 C

ATOM 2915 C GLY B 183 11. .794 -17. .358 7. .109 1. .00 31. .01 C

ATOM 2916 O GLY B 183 12. .001 -17. .940 8. .173 1. .00 30. .30 O

ATOM 2917 N ASN B 184 11. .343 -16. .112 7. .037 1. .00 33. .16 N

ATOM 2918 CA ASN B 184 10. .974 -15. .313 8. .193 1. .00 31. .41 C

ATOM 2919 C ASN B 184 10. .202 -16. .208 9. .164 1. .00 32. .72 C

ATOM 2920 O ASN B 184 9. .105 -16. .698 8. .832 1. .00 28. .90 O

ATOM 2921 CB ASN B 184 10. .090 -14. .161 7. .697 1. .00 33. .23 C

ATOM 2922 CG ASN B 184 9. .820 -13. .118 8. .755 1. .00 34. .50 c

ATOM 2923 OD1 ASN B 184 9. .656 -13. .425 9. .936 1. .00 38. .66 0

ATOM 2924 ND2 ASN B 184 9. .758 -11. .870 8. .330 1. .00 33. .70 N

ATOM 2925 N SER B 185 10. .786 -16. .431 10. .344 1. .00 32. .19 N

ATOM 2926 CA SER B 185 10. .211 -17. .328 11. .338 1. .00 33. .12 C

ATOM 2927 C SER B 185 8. .882 -16. .827 11. .919 1. .00 33. .11 C

ATOM 2928 O SER B 185 8. .167 -17. .584 12. .547 1. .00 32. .36 O

ATOM 2929 CB SER B 185 11. .195 -17. .553 12. .474 1. .00 34. .97 C

ATOM 2930 OG SER B 185 11. .415 -16. .318 13. .128 1. .00 39. .48 O

ATOM 2931 N LYS B 186 8. .555 -15. .556 11. .720 1. .00 33. .48 N

ATOM 2932 CA LYS B 186 7. .254 -15. .052 12. .175 1. .00 33. .75 C

ATOM 2933 C LYS B 186 6. .129 -15. .549 11. .260 1. .00 29. .80 C

ATOM 2934 O LYS B 186 4. .960 -15. .490 11. .619 1. .00 26. .51 O

ATOM 2935 CB LYS B 186 7. .260 -13. .523 12. .259 1. .00 35. .91 C

ATOM 2936 CG LYS B 186 8. .287 -12. .951 13. .237 1. .00 40. .18 c

ATOM 2937 CD LYS B 186 8. .037 -11. .472 13. .561 1. .00 43. .38 c

ATOM 2938 CE LYS B 186 8. .399 -10. .525 12. .418 1. .00 45. .77 c

ATOM 2939 NZ LYS B 186 9. .823 -10. .081 12. .473 1. .00 48. .12 N

ATOM 2940 N PHE B 187 6. .508 -16. .056 10. .090 1. .00 27. .71 N

ATOM 2941 CA PHE B 187 5. .558 -16. .383 9. .034 1. .00 27. .47 C

ATOM 2942 C PHE B 187 5. .586 -17. .850 8. .596 1. .00 25. .53 C

ATOM 2943 O PHE B 187 4. .945 -18. .224 7. .607 1. .00 26. .31 O

ATOM 2944 CB PHE B 187 5. .741 -15. .434 7. .835 1. .00 28. .41 C

ATOM 2945 CG PHE B 187 5. .215 -14. .040 8. .086 1. .00 30. .40 C

ATOM 2946 CD1 PHE B 187 6. .025 -13. .061 8. .666 1. .00 31. .03 C

ATOM 2947 CD2 PHE B 187 3. .904 -13. .711 7. .761 1. .00 31. .25 C

ATOM 2948 CE1 PHE B 187 5. .544 -11. .778 8. .905 1. .00 32. .45 c

ATOM 2949 CE2 PHE B 187 3. .408 -12. .425 8. .001 1. .00 32. .58 c

ATOM 2950 CZ PHE B 187 4. .230 -11. .460 8. .571 1. .00 31. .58 c

ATOM 2951 N THR B 188 6. .311 -18. .686 9. .329 1. .00 24. .12 N

ATOM 2952 CA THR B 188 6. .321 -20. .119 9. .007 1. .00 23. .74 C

ATOM 2953 C THR B 188 5. .104 -20. .808 9. .620 1. .00 23. .26 C

ATOM 2954 O THR B 188 4. .713 -20. .519 10. .759 1. .00 23. .49 0

ATOM 2955 CB THR B 188 7. .622 -20. .818 9. .456 1. .00 24. .00 c

ATOM 2956 OG1 THR B 188 7. .881 -20. .477 10. .804 1. .00 24. .90 0

ATOM 2957 CG2 THR B 188 8. .832 -20. .334 8. .641 1. .00 24. .60 c

ATOM 2958 N TYR B 189 4. .486 -21. .704 8. .857 1. .00 22. .12 N

ATOM 2959 CA TYR B 189 3. .480 -22. .582 9. .427 1. .00 20. .62 C

ATOM 2960 C TYR B 189 4. .195 -23. .747 10. .102 1. .00 20. .20 C

ATOM 2961 O TYR B 189 5. .420 -23. .854 10. .017 1. .00 18. .64 0

ATOM 2962 CB TYR B 189 2. .489 -23. .068 8. .353 1. .00 19. .84 c

ATOM 2963 CG TYR B 189 3. .120 -23. .681 7. .116 1. .00 20. .88 c

ATOM 2964 CD1 TYR B 189 3. .926 -24. .828 7. .198 1. .00 20. .54 c

ATOM 2965 CD2 TYR B 189 2. .872 -23. .148 5. .842 1. .00 20. .82 c

ATOM 2966 CE1 TYR B 189 4. .497 -25. .392 6. .057 1. .00 20. .57 c

ATOM 2967 CE2 TYR B 189 3. .431 -23. .717 4. .695 1. .00 20. .58 c

ATOM 2968 CZ TYR B 189 4. .242 -24. .829 4. .801 1. .00 20. .73 c

ATOM 2969 OH TYR B 189 4. .811 -25. .382 3. .646 1. .00 21. .64 0

ATOM 2970 N THR B 190 3. .435 -24. .616 10. .766 1. .00 19. .93 N

ATOM 2971 CA THR B 190 3. .981 -25. .879 11. .268 1. .00 21. .15 c

ATOM 2972 C THR B 190 3. .121 -27. .000 10. .711 1. .00 21. .49 c

ATOM 2973 O THR B 190 1. .945 -26. .797 10. .378 1. .00 22. .00 0

ATOM 2974 CB THR B 190 4. .034 -25. .982 12. .823 1. .00 21. .52 c ATOM 2975 OG1 THR B 190 2..716 -26..141 13..344 1..00 22..39 O

ATOM 2976 CG2 THR B 190 4. .690 -24. .753 13. .457 1. .00 21. .18 C

ATOM 2977 N VAL B 191 3. .703 -28. .184 10. .623 1. .00 20. .10 N

ATOM 2978 CA VAL B 191 3. .020 -29. .314 10. .041 1. .00 19. .50 C

ATOM 2979 C VAL B 191 2. .728 -30. .284 11. .167 1. .00 18. .87 C

ATOM 2980 O VAL B 191 3. .626 -30. .643 11. .951 1. .00 18. .28 O

ATOM 2981 CB VAL B 191 3. .874 -29. .956 8. .929 1. .00 20. .21 C

ATOM 2982 CGI VAL B 191 3. .239 -31. .227 8. .417 1. .00 19. .53 C

ATOM 2983 CG2 VAL B 191 4. .092 -28. .959 7. .784 1. .00 20. .73 c

ATOM 2984 N LEU B 192 1. .473 -30. .703 11. .243 1. .00 18. .58 N

ATOM 2985 CA LEU B 192 0. .997 -31. .538 12. .349 1. .00 19. .62 C

ATOM 2986 C LEU B 192 1. .033 -33. .015 12. .025 1. .00 19. .87 C

ATOM 2987 O LEU B 192 1. .132 -33. .859 12. .928 1. .00 18. .44 O

ATOM 2988 CB LEU B 192 -0. .409 -31. .125 12. .782 1. .00 19. .40 C

ATOM 2989 CG LEU B 192 -0. .578 -29. .678 13. .267 1. .00 20. .26 c

ATOM 2990 CD1 LEU B 192 -2. .017 -29. .542 13. .774 1. .00 19. .60 c

ATOM 2991 CD2 LEU B 192 0. .438 -29. .333 14. .362 1. .00 19. .43 c

ATOM 2992 N GLU B 193 0. .899 -33. .311 10. .735 1. .00 21. .29 N

ATOM 2993 CA GLU B 193 1. .152 -34. .626 10. .166 1. .00 22. .19 C

ATOM 2994 C GLU B 193 1. .452 -34. .458 8. .664 1. .00 22. .85 C

ATOM 2995 O GLU B 193 1. .050 -33. .469 8. .046 1. .00 21. .18 O

ATOM 2996 CB GLU B 193 -0. .033 -35. .571 10. .394 1. .00 23. .69 c

ATOM 2997 CG GLU B 193 -1. .155 -35. .448 9. .395 1. .00 25. .92 c

ATOM 2998 CD GLU B 193 -2. .414 -36. .167 9. .839 1. .00 28. .17 c

ATOM 2999 OE1 GLU B 193 -3. .024 -35. .720 10. .831 1. .00 28. .92 0

ATOM 3000 OE2 GLU B 193 -2. .822 -37. .156 9. .178 1. .00 29. .37 0

ATOM 3001 N ASP B 194 2. .137 -35. .433 8. .077 1. .00 23. .62 N

ATOM 3002 CA ASP B 194 2. .584 -35. .323 6. .684 1. .00 23. .36 C

ATOM 3003 C ASP B 194 2. .594 -36. .679 6. .007 1. .00 23. .79 C

ATOM 3004 O ASP B 194 3. .554 -37. .416 6. .143 1. .00 24. .50 0

ATOM 3005 CB ASP B 194 3. .981 -34. .686 6. .622 1. .00 23. .25 c

ATOM 3006 CG ASP B 194 4. .390 -34. .287 5. .199 1. .00 22. .87 c

ATOM 3007 OD1 ASP B 194 3. .596 -34. .467 4. .257 1. .00 21. .87 0

ATOM 3008 OD2 ASP B 194 5. .505 -33. .774 5. .038 1. .00 22. .31 0

ATOM 3009 N GLY B 195 1. .517 -37. .009 5. .296 1. .00 23. .12 N

ATOM 3010 CA GLY B 195 1. .418 -38. .280 4. .585 1. .00 23. .24 C

ATOM 3011 C GLY B 195 1. .612 -38. .160 3. .078 1. .00 24. .79 C

ATOM 3012 O GLY B 195 1. .372 -39. .106 2. .348 1. .00 26. .64 0

ATOM 3013 N CYS B 196 2. .054 -36. .993 2. .614 1. .00 24. .28 N

ATOM 3014 CA CYS B 196 2. .117 -36. .687 1. .191 1. .00 23. .29 C

ATOM 3015 C CYS B 196 3. .542 -36. .743 0. .608 1. .00 24. .68 C

ATOM 3016 O CYS B 196 3. .749 -36. .301 -0. .531 1. .00 24. .79 O

ATOM 3017 CB CYS B 196 1. .549 -35. .280 0. .968 1. .00 22. .67 c

ATOM 3018 SG CYS B 196 -0. .195 -35. .103 1. .398 1. .00 21. .13 s

ATOM 3019 N THR B 197 4. .506 -37. .285 1. .365 1. .00 23. .03 N

ATOM 3020 CA THR B 197 5. .939 -37. .190 1. .021 1. .00 23. .48 C

ATOM 3021 C THR B 197 6. .435 -37. .952 -0. .227 1. .00 25. .56 C

ATOM 3022 O THR B 197 7. .583 -37. .724 -0. .654 1. .00 25. .03 O

ATOM 3023 CB THR B 197 6. .855 -37. .631 2. .187 1. .00 22. .39 c

ATOM 3024 OG1 THR B 197 6. .695 -39. .038 2. .425 1. .00 21. .32 0

ATOM 3025 CG2 THR B 197 6. .544 -36. .840 3. .461 1. .00 22. .64 c

ATOM 3026 N LYS B 198 5. .614 -38. .853 -0. .776 1. .00 26. .68 N

ATOM 3027 CA LYS B 198 5. .958 -39. .632 -1. .985 1. .00 30. .56 C

ATOM 3028 C LYS B 198 4. .768 -39. .720 -2. .923 1. .00 31. .50 C

ATOM 3029 O LYS B 198 3. .624 -39. .693 -2. .467 1. .00 32. .91 O

ATOM 3030 CB LYS B 198 6. .317 -41. .098 -1. .655 1. .00 33. .90 c

ATOM 3031 CG LYS B 198 6. .846 -41. .412 -0. .267 1. .00 36. .05 c

ATOM 3032 CD LYS B 198 7. .007 -42. .926 -0. .079 1. .00 38. .43 c

ATOM 3033 CE LYS B 198 6. .906 -43. .287 1. .402 1. .00 42. .82 c

ATOM 3034 NZ LYS B 198 6. .815 -44. .746 1. .698 1. .00 41. .34 N

ATOM 3035 N HIS B 199 5. .028 -39. .883 -4. .221 1. .00 33. .04 N ATOM 3036 CA HIS B 199 3..968 -40..168 -5..198 1..00 33..08 C

ATOM 3037 C HIS B 199 3. .683 -41. .646 -5. .199 1. .00 35. .68 C

ATOM 3038 O HIS B 199 4. .450 -42. .439 -5. .766 1. .00 36. .09 O

ATOM 3039 CB HIS B 199 4. .389 -39. .747 -6. .604 1. .00 33. .37 C

ATOM 3040 CG HIS B 199 4. .653 -38. .261 -6. .769 1. .00 33. .74 C

ATOM 3041 ND1 HIS B 199 4. .787 -37. .686 -7. .977 1. .00 33. .38 N

ATOM 3042 CD2 HIS B 199 4. .818 -37. .246 -5. .836 1. .00 32. .64 C

ATOM 3043 CE1 HIS B 199 5. .043 -36. .375 -7. .828 1. .00 32. .24 C

ATOM 3044 NE2 HIS B 199 5. .055 -36. .104 -6. .521 1. .00 33. .68 N

ATOM 3045 N THR B 200 2. .576 -42. .044 -4. .584 1. .00 35. .86 N

ATOM 3046 CA THR B 200 2. .257 -43. .458 -4. .441 1. .00 34. .82 C

ATOM 3047 C THR B 200 1. .140 -43. .887 -5. .374 1. .00 36. .25 C

ATOM 3048 O THR B 200 0. .854 -45. .076 -5. .491 1. .00 37. .56 O

ATOM 3049 CB THR B 200 1. .792 -43. .776 -3. .018 1. .00 34. .32 C

ATOM 3050 OG1 THR B 200 0. .527 -43. .146 -2. .805 1. .00 35. .68 O

ATOM 3051 CG2 THR B 200 2. .793 -43. .268 -1. .989 1. .00 35. .72 C

ATOM 3052 N GLY B 201 0. .486 -42. .930 -6. .020 1. .00 36. .04 N

ATOM 3053 CA GLY B 201 -0. .743 -43. .218 -6. .763 1. .00 37. .09 C

ATOM 3054 C GLY B 201 -1. .943 -43. .388 -5. .841 1. .00 41. .16 C

ATOM 3055 O GLY B 201 -3. .036 -43. .709 -6. .298 1. .00 46. .03 O

ATOM 3056 N GLU B 202 -1. .746 -43. .173 -4. .540 1. .00 40. .39 N

ATOM 3057 CA GLU B 202 -2. .832 -43. .249 -3. .552 1. .00 40. .92 C

ATOM 3058 C GLU B 202 -3. .119 -41. .885 -2. .900 1. .00 36. .74 C

ATOM 3059 O GLU B 202 -2. .328 -40. .961 -3. .019 1. .00 32. .39 O

ATOM 3060 CB GLU B 202 -2. .509 -44. .290 -2. .470 1. .00 43. .79 C

ATOM 3061 CG GLU B 202 -2. .540 -45. .735 -2. .942 1. .00 49. .32 c

ATOM 3062 CD GLU B 202 -3. .934 -46. .193 -3. .342 1. .00 55. .28 c

ATOM 3063 OE1 GLU B 202 -4. .479 -45. .670 -4. .344 1. .00 59. .97 0

ATOM 3064 OE2 GLU B 202 -4. .492 -47. .077 -2. .651 1. .00 57. .71 0

ATOM 3065 N TRP B 203 -4. .252 -41. .779 -2. .209 1. .00 35. .49 N

ATOM 3066 CA TRP B 203 -4. .647 -40. .543 -1. .543 1. .00 32. .09 C

ATOM 3067 C TRP B 203 -4. .158 -40. .478 -0. .124 1. .00 31. .24 C

ATOM 3068 O TRP B 203 -4. .237 -41. .454 0. .626 1. .00 30. .71 0

ATOM 3069 CB TRP B 203 -6. .159 -40. .366 -1. .593 1. .00 31. .85 c

ATOM 3070 CG TRP B 203 -6. .640 -39. .789 -2. .907 1. .00 32. .16 c

ATOM 3071 CD1 TRP B 203 -7. .166 -40. .480 -3. .996 1. .00 31. .80 c

ATOM 3072 CD2 TRP B 203 -6. .635 -38. .378 -3. .325 1. .00 31. .96 c

ATOM 3073 NE1 TRP B 203 -7. .478 -39. .623 -5. .016 1. .00 31. .66 N

ATOM 3074 CE2 TRP B 203 -7. .188 -38. .353 -4. .688 1. .00 32. .26 C

ATOM 3075 CE3 TRP B 203 -6. .265 -37. .178 -2. .725 1. .00 30. .59 C

ATOM 3076 CZ2 TRP B 203 -7. .357 -37. .170 -5. .393 1. .00 31. .33 c

ATOM 3077 CZ3 TRP B 203 -6. .410 -35. .998 -3. .456 1. .00 31. .09 c

ATOM 3078 CH2 TRP B 203 -6. .948 -35. .991 -4. .755 1. .00 32. .18 c

ATOM 3079 N SER B 204 -3. .645 -39. .317 0. .259 1. .00 29. .98 N

ATOM 3080 CA SER B 204 -3. .237 -39. .087 1. .637 1. .00 29. .00 C

ATOM 3081 C SER B 204 -3. .416 -37. .607 1. .997 1. .00 28. .78 C

ATOM 3082 O SER B 204 -4. .069 -36. .851 1. .264 1. .00 28. .32 O

ATOM 3083 CB SER B 204 -1. .793 -39. .551 1. .840 1. .00 28. .54 c

ATOM 3084 OG SER B 204 -1. .526 -39. .790 3. .214 1. .00 32. .11 0

ATOM 3085 N LYS B 205 -2. .835 -37. .184 3. .119 1. .00 28. .15 N

ATOM 3086 CA LYS B 205 -2. .995 -35. .803 3. .563 1. .00 24. .71 C

ATOM 3087 C LYS B 205 -1. .859 -35. .278 4. .440 1. .00 23. .03 C

ATOM 3088 O LYS B 205 -1. .105 -36. .022 5. .067 1. .00 22. .47 O

ATOM 3089 CB LYS B 205 -4. .348 -35. .629 4. .267 1. .00 25. .12 c

ATOM 3090 CG LYS B 205 -4. .376 -36. .239 5. .648 1. .00 24. .49 c

ATOM 3091 CD LYS B 205 -5. .782 -36. .406 6. .173 1. .00 26. .92 c

ATOM 3092 CE LYS B 205 -5. .737 -37. .327 7. .377 1. .00 28. .06 c

ATOM 3093 NZ LYS B 205 -6. .580 -36. .772 8. .455 1. .00 29. .96 N

ATOM 3094 N THR B 206 -1. .755 -33. .963 4. .461 1. .00 21. .50 N

ATOM 3095 CA THR B 206 -0. .805 -33. .262 5. .292 1. .00 20. .98 C

ATOM 3096 C THR B 206 -1. .618 -32. .158 5. .951 1. .00 20. .99 C ATOM 3097 O THR B 206 -2..462 -31..527 5..300 1..00 20..18 O

ATOM 3098 CB THR B 206 0. .327 -32. .691 4. .417 1. .00 20. .92 C

ATOM 3099 OG1 THR B 206 1. .014 -33. .793 3. .793 1. .00 19. .95 O

ATOM 3100 CG2 THR B 206 1. .305 -31. .869 5. .232 1. .00 19. .33 C

ATOM 3101 N VAL B 207 -1. .389 -31. .954 7. .245 1. .00 19. .70 N

ATOM 3102 CA VAL B 207 -2. .141 -30. .965 7. .992 1. .00 18. .50 C

ATOM 3103 C VAL B 207 -1. .191 -29. .840 8. .392 1. .00 18. .92 C

ATOM 3104 O VAL B 207 -0. .131 -30. .085 9. .018 1. .00 18. .13 O

ATOM 3105 CB VAL B 207 -2. .816 -31. .586 9. .233 1. .00 18. .35 C

ATOM 3106 CGI VAL B 207 -3. .490 -30. .506 10. .056 1. .00 18. .19 c

ATOM 3107 CG2 VAL B 207 -3. .810 -32. .690 8. .835 1. .00 17. .41 c

ATOM 3108 N PHE B 208 -1. .573 -28. .617 8. .021 1. .00 17. .40 N

ATOM 3109 CA PHE B 208 -0. .778 -27. .450 8. .316 1. .00 18. .29 C

ATOM 3110 C PHE B 208 -1. .478 -26. .613 9. .376 1. .00 18. .80 C

ATOM 3111 O PHE B 208 -2. .693 -26. .603 9. .436 1. .00 20. .46 O

ATOM 3112 CB PHE B 208 -0. .608 -26. .608 7. .057 1. .00 18. .04 c

ATOM 3113 CG PHE B 208 0. .086 -27. .321 5. .921 1. .00 18. .60 c

ATOM 3114 CD1 PHE B 208 -0. .624 -28. .164 5. .068 1. .00 17. .84 c

ATOM 3115 CD2 PHE B 208 1. .441 -27. .104 5. .678 1. .00 18. .80 c

ATOM 3116 CE1 PHE B 208 0. .014 -28. .775 3. .998 1. .00 19. .00 c

ATOM 3117 CE2 PHE B 208 2. .083 -27. .718 4. .602 1. .00 19. .59 c

ATOM 3118 CZ PHE B 208 1. .367 -28. .558 3. .770 1. .00 18. .80 c

ATOM 3119 N GLU B 209 -0. .708 -25. .880 10. .170 1. .00 19. .30 N

ATOM 3120 CA GLU B 209 -1. .252 -24. .954 11. .159 1. .00 20. .57 C

ATOM 3121 C GLU B 209 -0. .457 -23. .664 11. .161 1. .00 20. .24 c

ATOM 3122 O GLU B 209 0. .761 -23. .689 11. .068 1. .00 19. .41 0

ATOM 3123 CB GLU B 209 -1. .176 -25. .558 12. .559 1. .00 21. .61 c

ATOM 3124 CG GLU B 209 -1. .706 -24. .660 13. .659 1. .00 25. .14 c

ATOM 3125 CD GLU B 209 -1. .680 -25. .343 15. .006 1. .00 27. .95 c

ATOM 3126 OE1 GLU B 209 -0. .592 -25. .543 15. .558 1. .00 30. .66 0

ATOM 3127 OE2 GLU B 209 -2. .758 -25. .688 15. .513 1. .00 32. .31 0

ATOM 3128 N TYR B 210 -1. .150 -22. .534 11. .249 1. .00 20. .23 N

ATOM 3129 CA TYR B 210 -0. .470 -21. .291 11. .561 1. .00 21. .14 C

ATOM 3130 C TYR B 210 -1. .039 -20. .746 12. .843 1. .00 21. .14 c

ATOM 3131 O TYR B 210 -2. .248 -20. .719 13. .020 1. .00 22. .04 0

ATOM 3132 CB TYR B 210 -0. .591 -20. .265 10. .444 1. .00 20. .99 c

ATOM 3133 CG TYR B 210 0. .199 -19. .006 10. .740 1. .00 21. .52 c

ATOM 3134 CD1 TYR B 210 1. .596 -19. .024 10. .741 1. .00 21. .76 c

ATOM 3135 CD2 TYR B 210 -0. .442 -17. .812 11. .034 1. .00 21. .36 c

ATOM 3136 CE1 TYR B 210 2. .333 -17. .880 11. .007 1. .00 22. .21 c

ATOM 3137 CE2 TYR B 210 0. .287 -16. .667 11. .305 1. .00 22. .51 c

ATOM 3138 CZ TYR B 210 1. .672 -16. .714 11. .279 1. .00 21. .77 c

ATOM 3139 OH TYR B 210 2. .394 -15. .596 11. .530 1. .00 23. .56 0

ATOM 3140 N ARG B 211 -0. .162 -20. .329 13. .742 1. .00 22. .38 N

ATOM 3141 CA ARG B 211 -0. .569 -19. .921 15. .079 1. .00 24. .14 c

ATOM 3142 C ARG B 211 0. .176 -18. .622 15. .325 1. .00 23. .57 c

ATOM 3143 O ARG B 211 1. .360 -18. .547 15. .055 1. .00 22. .67 0

ATOM 3144 CB ARG B 211 -0. .197 -21. .039 16. .075 1. .00 27. .00 c

ATOM 3145 CG ARG B 211 -0. .353 -20. .732 17. .556 1. .00 31. .38 c

ATOM 3146 CD ARG B 211 -0. .129 -21. .995 18. .393 1. .00 32. .65 c

ATOM 3147 NE ARG B 211 -1. .051 -23. .059 18. .013 1. .00 33. .13 N

ATOM 3148 CZ ARG B 211 -2. .261 -23. .246 18. .548 1. .00 33. .54 C

ATOM 3149 NH1 ARG B 211 -2. .714 -22. .445 19. .512 1. .00 31. .58 N

ATOM 3150 NH2 ARG B 211 -3. .026 -24. .239 18. .113 1. .00 30. .46 N

ATOM 3151 N THR B 212 -0. .507 -17. .585 15. .785 1. .00 23. .50 N

ATOM 3152 CA THR B 212 0. .144 -16. .281 15. .894 1. .00 23. .61 C

ATOM 3153 C THR B 212 -0. .454 -15. .397 16. .961 1. .00 25. .40 C

ATOM 3154 O THR B 212 -1. .612 -15. .561 17. .350 1. .00 26. .63 O

ATOM 3155 CB THR B 212 0. .119 -15. .514 14. .553 1. .00 23. .13 C

ATOM 3156 OG1 THR B 212 0. .732 -14. .231 14. .720 1. .00 23. .22 O

ATOM 3157 CG2 THR B 212 -1. .316 -15. .318 14. .043 1. .00 22. .88 C ATOM 3158 N ARG B 213 0..343 -14..438 17..416 1..00 27..30 N

ATOM 3159 CA ARG B 213 -0. .142 -13. .407 18. .322 1. .00 28. .71 C

ATOM 3160 C ARG B 213 -0. .581 -12. .172 17. .561 1. .00 26. .93 C

ATOM 3161 O ARG B 213 -1. .123 -11. .232 18. .145 1. .00 27. .62 O

ATOM 3162 CB ARG B 213 0. .916 -13. .097 19. .391 1. .00 33. .24 C

ATOM 3163 CG ARG B 213 1. .026 -14. .255 20. .381 1. .00 40. .26 C

ATOM 3164 CD ARG B 213 2. .190 -14. .120 21. .330 1. .00 48. .59 C

ATOM 3165 NE ARG B 213 1. .757 -14. .372 22. .703 1. .00 59. .16 N

ATOM 3166 CZ ARG B 213 1. .522 -13. .416 23. .600 1. .00 62. .93 C

ATOM 3167 NH1 ARG B 213 1. .689 -12. .132 23. .281 1. .00 64. .07 N

ATOM 3168 NH2 ARG B 213 1. .129 -13. .743 24. .822 1. .00 63. .14 N

ATOM 3169 N LYS B 214 -0. .365 -12. .183 16. .253 1. .00 25. .18 N

ATOM 3170 CA LYS B 214 -0. .838 -11. .113 15. .397 1. .00 26. .56 C

ATOM 3171 C LYS B 214 -1. .997 -11. .620 14. .538 1. .00 23. .60 C

ATOM 3172 O LYS B 214 -1. .827 -11. .908 13. .349 1. .00 22. .19 O

ATOM 3173 CB LYS B 214 0. .304 -10. .578 14. .526 1. .00 29. .35 C

ATOM 3174 CG LYS B 214 1. .441 -9. .931 15. .313 1. .00 35. .70 C

ATOM 3175 CD LYS B 214 1. .133 -8. .492 15. .731 1. .00 41. .16 C

ATOM 3176 CE LYS B 214 0. .858 -7. .586 14. .528 1. .00 45. .96 C

ATOM 3177 NZ LYS B 214 1. .125 -6. .147 14. .831 1. .00 47. .39 N

ATOM 3178 N ALA B 215 -3. .179 -11. .685 15. .149 1. .00 21. .48 N

ATOM 3179 CA ALA B 215 -4. .359 -12. .361 14. .567 1. .00 20. .83 C

ATOM 3180 C ALA B 215 -4. .848 -11. .677 13. .315 1. .00 19. .88 C

ATOM 3181 O ALA B 215 -5. .680 -12. .207 12. .586 1. .00 19. .76 O

ATOM 3182 CB ALA B 215 -5. .489 -12. .465 15. .601 1. .00 19. .94 C

ATOM 3183 N VAL B 216 -4. .336 -10. .486 13. .064 1. .00 20. .23 N

ATOM 3184 CA VAL B 216 -4. .619 -9. .780 11. .804 1. .00 20. .33 C

ATOM 3185 C VAL B 216 -4. .166 -10. .603 10. .571 1. .00 20. .23 C

ATOM 3186 O VAL B 216 -4. .730 -10. .477 9. .475 1. .00 20. .49 O

ATOM 3187 CB VAL B 216 -4. .040 -8. .326 11. .863 1. .00 20. .95 C

ATOM 3188 CGI VAL B 216 -2. .520 -8. .315 11. .896 1. .00 20. .98 c

ATOM 3189 CG2 VAL B 216 -4. .579 -7. .428 10. .765 1. .00 21. .01 c

ATOM 3190 N ARG B 217 -3. .183 -11. .478 10. .760 1. .00 19. .52 N

ATOM 3191 CA ARG B 217 -2. .659 -12. .291 9. .657 1. .00 20. .04 C

ATOM 3192 C ARG B 217 -3. .602 -13. .430 9. .284 1. .00 19. .49 C

ATOM 3193 O ARG B 217 -3. .469 -14. .037 8. .245 1. .00 17. .35 O

ATOM 3194 CB ARG B 217 -1. .294 -12. .870 10. .039 1. .00 21. .55 c

ATOM 3195 CG ARG B 217 -0. .323 -11. .803 10. .528 1. .00 22. .86 c

ATOM 3196 CD ARG B 217 1. .007 -12. .403 10. .909 1. .00 23. .96 c

ATOM 3197 NE ARG B 217 1. .959 -11. .354 11. .227 1. .00 24. .12 N

ATOM 3198 CZ ARG B 217 2. .979 -11. .516 12. .056 1. .00 26. .20 C

ATOM 3199 NH1 ARG B 217 3. .165 -12. .691 12. .664 1. .00 26. .37 N

ATOM 3200 NH2 ARG B 217 3. .794 -10. .501 12. .296 1. .00 27. .33 N

ATOM 3201 N LEU B 218 -4. .566 -13. .712 10. .147 1. .00 20. .28 N

ATOM 3202 CA LEU B 218 -5. .527 -14. .759 9. .876 1. .00 19. .69 C

ATOM 3203 C LEU B 218 -6. .898 -14. .135 9. .544 1. .00 19. .49 C

ATOM 3204 O LEU B 218 -7. .124 -12. .959 9. .865 1. .00 19. .97 O

ATOM 3205 CB LEU B 218 -5. .603 -15. .712 11. .067 1. .00 19. .12 C

ATOM 3206 CG LEU B 218 -4. .408 -16. .668 11. .192 1. .00 19. .30 C

ATOM 3207 CD1 LEU B 218 -4. .558 -17. .495 12. .471 1. .00 18. .09 C

ATOM 3208 CD2 LEU B 218 -4. .314 -17. .564 9. .970 1. .00 18. .78 C

ATOM 3209 N PRO B 219 -7. .806 -14. .905 8. .904 1. .00 18. .14 N

ATOM 3210 CA PRO B 219 -7. .737 -16. .297 8. .429 1. .00 18. .14 C

ATOM 3211 C PRO B 219 -6. .933 -16. .526 7. .137 1. .00 18. .66 C

ATOM 3212 O PRO B 219 -6. .469 -15. .580 6. .506 1. .00 18. .08 O

ATOM 3213 CB PRO B 219 -9. .195 -16. .627 8. .153 1. .00 17. .64 C

ATOM 3214 CG PRO B 219 -9. .776 -15. .322 7. .734 1. .00 17. .72 c

ATOM 3215 CD PRO B 219 -9. .130 -14. .319 8. .640 1. .00 18. .27 c

ATOM 3216 N ILE B 220 -6. .802 -17. .797 6. .760 1. .00 19. .29 N

ATOM 3217 CA ILE B 220 -6. .206 -18. .195 5. .504 1. .00 19. .43 C

ATOM 3218 C ILE B 220 -7. .219 -18. .008 4. .384 1. .00 19. .23 C ATOM 3219 O ILE B 220 -8..365 -18..413 4..497 1..00 17..86 O

ATOM 3220 CB ILE B 220 -5. .684 -19. .654 5. .587 1. .00 20. .30 C

ATOM 3221 CGI ILE B 220 -4. .578 -19. .745 6. .654 1. .00 19. .42 C

ATOM 3222 CG2 ILE B 220 -5. .146 -20. .155 4. .233 1. .00 18. .66 C

ATOM 3223 CD1 ILE B 220 -4. .463 -21. .134 7. .251 1. .00 20. .31 C

ATOM 3224 N VAL B 221 -6. .782 -17. .375 3. .301 1. .00 19. .87 N

ATOM 3225 CA VAL B 221 -7. .692 -17. .044 2. .213 1. .00 22. .01 C

ATOM 3226 C VAL B 221 -7. .319 -17. .805 0. .939 1. .00 23. .18 C

ATOM 3227 O VAL B 221 -8. .121 -17. .931 0. .045 1. .00 25. .43 O

ATOM 3228 CB VAL B 221 -7. .765 -15. .511 1. .958 1. .00 22. .24 C

ATOM 3229 CGI VAL B 221 -8. .262 -14. .768 3. .199 1. .00 21. .82 c

ATOM 3230 CG2 VAL B 221 -6. .408 -14. .961 1. .550 1. .00 22. .32 c

ATOM 3231 N ASP B 222 -6. .105 -18. .341 0. .878 1. .00 23. .60 N

ATOM 3232 CA ASP B 222 -5. .658 -19. .061 -0. .318 1. .00 23. .78 C

ATOM 3233 C ASP B 222 -4. .510 -20. .019 -0. .005 1. .00 22. .61 C

ATOM 3234 O ASP B 222 -3. .851 -19. .915 1. .049 1. .00 21. .43 O

ATOM 3235 CB ASP B 222 -5. .229 -18. .065 -1. .415 1. .00 24. .16 c

ATOM 3236 CG ASP B 222 -5. .565 -18. .542 -2. .846 1. .00 25. .70 c

ATOM 3237 OD1 ASP B 222 -5. .825 -19. .745 -3. .087 1. .00 25. .95 0

ATOM 3238 OD2 ASP B 222 -5. .531 -17. .688 -3. .763 1. .00 28. .06 0

ATOM 3239 N ILE B 223 -4. .266 -20. .923 -0. .958 1. .00 22. .82 N

ATOM 3240 CA ILE B 223 -3. .255 -21. .959 -0. .876 1. .00 21. .98 C

ATOM 3241 C ILE B 223 -2. .573 -22. .069 -2. .241 1. .00 23. .13 C

ATOM 3242 O ILE B 223 -3. .234 -22. .054 -3. .270 1. .00 25. .08 0

ATOM 3243 CB ILE B 223 -3. .877 -23. .318 -0. .430 1. .00 21. .05 c

ATOM 3244 CGI ILE B 223 -2. .813 -24. .411 -0. .270 1. .00 21. .71 c

ATOM 3245 CG2 ILE B 223 -4. .970 -23. .787 -1. .380 1. .00 21. .73 c

ATOM 3246 CD1 ILE B 223 -3. .257 -25. .594 0. .585 1. .00 20. .10 c

ATOM 3247 N ALA B 224 -1. .251 -22. .170 -2. .239 1. .00 21. .94 N

ATOM 3248 CA ALA B 224 -0. .493 -22. .368 -3. .458 1. .00 22. .30 C

ATOM 3249 C ALA B 224 0. .354 -23. .626 -3. .361 1. .00 20. .97 C

ATOM 3250 O ALA B 224 1. .471 -23. .576 -2. .857 1. .00 21. .59 0

ATOM 3251 CB ALA B 224 0. .402 -21. .166 -3. .749 1. .00 20. .86 c

ATOM 3252 N PRO B 225 -0. .172 -24. .743 -3. .853 1. .00 21. .29 N

ATOM 3253 CA PRO B 225 0. .646 -25. .939 -4. .028 1. .00 22. .77 C

ATOM 3254 C PRO B 225 1. .811 -25. .679 -5. .000 1. .00 25. .03 C

ATOM 3255 O PRO B 225 1. .719 -24. .791 -5. .848 1. .00 24. .95 O

ATOM 3256 CB PRO B 225 -0. .338 -26. .964 -4. .616 1. .00 22. .46 c

ATOM 3257 CG PRO B 225 -1. .716 -26. .404 -4. .375 1. .00 21. .39 c

ATOM 3258 CD PRO B 225 -1. .548 -24. .913 -4. .365 1. .00 21. .57 c

ATOM 3259 N TYR B 226 2. .903 -26. .420 -4. .842 1. .00 25. .94 N

ATOM 3260 CA TYR B 226 4. .055 -26. .348 -5. .742 1. .00 28. .32 C

ATOM 3261 C TYR B 226 4. .140 -27. .582 -6. .600 1. .00 27. .98 C

ATOM 3262 O TYR B 226 4. .246 -27. .489 -7. .823 1. .00 29. .03 O

ATOM 3263 CB TYR B 226 5. .350 -26. .227 -4. .940 1. .00 31. .21 c

ATOM 3264 CG TYR B 226 6. .634 -26. .192 -5. .756 1. .00 33. .06 c

ATOM 3265 CD1 TYR B 226 7. .258 -27. .379 -6. .167 1. .00 32. .67 c

ATOM 3266 CD2 TYR B 226 7. .246 -24. .977 -6. .084 1. .00 33. .08 c

ATOM 3267 CE1 TYR B 226 8. .437 -27. .356 -6. .894 1. .00 33. .15 c

ATOM 3268 CE2 TYR B 226 8. .436 -24. .946 -6. .811 1. .00 33. .64 c

ATOM 3269 CZ TYR B 226 9. .024 -26. .141 -7. .212 1. .00 34. .20 c

ATOM 3270 OH TYR B 226 10. .198 -26. .138 -7. .932 1. .00 33. .80 0

ATOM 3271 N ASP B 227 4. .121 -28. .747 -5. .962 1. .00 27. .94 N

ATOM 3272 CA ASP B 227 4. .242 -30. .008 -6. .698 1. .00 28. .07 c

ATOM 3273 C ASP B 227 2. .927 -30. .377 -7. .397 1. .00 27. .05 c

ATOM 3274 O ASP B 227 2. .273 -31. .350 -7. .033 1. .00 27. .35 0

ATOM 3275 CB ASP B 227 4. .763 -31. .143 -5. .804 1. .00 27. .46 c

ATOM 3276 CG ASP B 227 5. .059 -32. .424 -6. .592 1. .00 28. .20 c

ATOM 3277 OD1 ASP B 227 5. .393 -32. .328 -7. .791 1. .00 27. .49 0

ATOM 3278 OD2 ASP B 227 4. .939 -33. .526 -6. .018 1. .00 28. .30 0

ATOM 3279 N ILE B 228 2. .550 -29. .578 -8. .399 1. .00 26. .38 N ATOM 3280 CA ILE B 228 1..342 -29..834 -9..197 1..00 28..56 C

ATOM 3281 C ILE B 228 1. .592 -29. .548 -10. .686 1. .00 29. .52 C

ATOM 3282 O ILE B 228 2. .612 -28. .937 -11. .045 1. .00 30. .47 O

ATOM 3283 CB ILE B 228 0. .142 -28. .978 -8. .707 1. .00 28. .10 C

ATOM 3284 CGI ILE B 228 0. .527 -27. .492 -8. .622 1. .00 27. .43 C

ATOM 3285 CG2 ILE B 228 -0. .362 -29. .484 -7. .364 1. .00 28. .15 C

ATOM 3286 CD1 ILE B 228 -0. .629 -26. .564 -8. .299 1. .00 27. .53 C

ATOM 3287 N GLY B 229 0. .661 -29. .971 -11. .538 1. .00 30. .35 N

ATOM 3288 CA GLY B 229 0. .723 -29. .651 -12. .966 1. .00 36. .22 C

ATOM 3289 C GLY B 229 0. .796 -30. .862 -13. .888 1. .00 39. .84 C

ATOM 3290 O GLY B 229 0. .348 -30. .793 -15. .033 1. .00 40. .42 O

ATOM 3291 N GLY B 230 1. .358 -31. .964 -13. .381 1. .00 40. .43 N

ATOM 3292 CA GLY B 230 1. .471 -33. .221 -14. .121 1. .00 38. .96 C

ATOM 3293 C GLY B 230 0. .129 -33. .930 -14. .249 1. .00 41. .35 C

ATOM 3294 O GLY B 230 -0. .763 -33. .716 -13. .421 1. .00 39. .01 O

ATOM 3295 N PRO B 231 -0. .020 -34. .780 -15. .296 1. .00 43. .30 N

ATOM 3296 CA PRO B 231 -1. .282 -35. .477 -15. .641 1. .00 42. .37 C

ATOM 3297 C PRO B 231 -1. .901 -36. .279 -14. .492 1. .00 42. .03 C

ATOM 3298 O PRO B 231 -3. .115 -36. .437 -14. .429 1. .00 39. .87 O

ATOM 3299 CB PRO B 231 -0. .868 -36. .431 -16. .778 1. .00 41. .99 C

ATOM 3300 CG PRO B 231 0. .635 -36. .453 -16. .770 1. .00 41. .94 c

ATOM 3301 CD PRO B 231 1. .064 -35. .117 -16. .241 1. .00 39. .84 c

ATOM 3302 N ASP B 232 -1. .066 -36. .780 -13. .592 1. .00 43. .77 N

ATOM 3303 CA ASP B 232 -1. .532 -37. .605 -12. .479 1. .00 45. .44 C

ATOM 3304 C ASP B 232 -1. .554 -36. .879 -11. .109 1. .00 42. .89 C

ATOM 3305 O ASP B 232 -1. .804 -37. .497 -10. .066 1. .00 39. .99 O

ATOM 3306 CB ASP B 232 -0. .678 -38. .878 -12. .404 1. .00 49. .87 c

ATOM 3307 CG ASP B 232 0. .826 -38. .586 -12. .374 1. .00 56. .73 c

ATOM 3308 OD1 ASP B 232 1. .262 -37. .439 -12. .676 1. .00 58. .02 0

ATOM 3309 OD2 ASP B 232 1. .583 -39. .529 -12. .048 1. .00 63. .47 0

ATOM 3310 N GLN B 233 -1. .299 -35. .576 -11. .109 1. .00 38. .33 N

ATOM 3311 CA GLN B 233 -1. .212 -34. .846 -9. .857 1. .00 34. .48 C

ATOM 3312 C GLN B 233 -2. .530 -34. .173 -9. .476 1. .00 34. .19 C

ATOM 3313 O GLN B 233 -3. .085 -33. .361 -10. .238 1. .00 33. .01 0

ATOM 3314 CB GLN B 233 -0. .058 -33. .856 -9. .900 1. .00 34. .33 c

ATOM 3315 CG GLN B 233 1. .288 -34. .487 -10. .217 1. .00 32. .07 c

ATOM 3316 CD GLN B 233 2. .407 -33. .475 -10. .114 1. .00 33. .07 c

ATOM 3317 OE1 GLN B 233 2. .506 -32. .588 -10. .947 1. .00 36. .22 0

ATOM 3318 NE2 GLN B 233 3. .246 -33. .589 -9. .078 1. .00 30. .34 N

ATOM 3319 N GLU B 234 -3. .018 -34. .532 -8. .285 1. .00 33. .55 N

ATOM 3320 CA GLU B 234 -4. .317 -34. .087 -7. .774 1. .00 32. .99 C

ATOM 3321 C GLU B 234 -4. .309 -33. .650 -6. .309 1. .00 31. .33 C

ATOM 3322 O GLU B 234 -3. .518 -34. .156 -5. .495 1. .00 30. .01 O

ATOM 3323 CB GLU B 234 -5. .337 -35. .201 -7. .929 1. .00 33. .75 C

ATOM 3324 CG GLU B 234 -5. .783 -35. .454 -9. .352 1. .00 37. .30 C

ATOM 3325 CD GLU B 234 -6. .883 -36. .504 -9. .394 1. .00 40. .91 C

ATOM 3326 OE1 GLU B 234 -7. .913 -36. .337 -8. .709 1. .00 44. .65 0

ATOM 3327 OE2 GLU B 234 -6. .714 -37. .513 -10. .095 1. .00 43. .11 0

ATOM 3328 N PHE B 235 -5. .204 -32. .718 -5. .971 1. .00 29. .88 N

ATOM 3329 CA PHE B 235 -5. .356 -32. .281 -4. .584 1. .00 28. .49 C

ATOM 3330 C PHE B 235 -6. .768 -31. .888 -4. .198 1. .00 28. .36 C

ATOM 3331 O PHE B 235 -7. .596 -31. .533 -5. .052 1. .00 28. .54 O

ATOM 3332 CB PHE B 235 -4. .367 -31. .162 -4. .233 1. .00 27. .87 c

ATOM 3333 CG PHE B 235 -4. .698 -29. .823 -4. .835 1. .00 28. .03 c

ATOM 3334 CD1 PHE B 235 -5. .594 -28. .960 -4. .200 1. .00 26. .75 c

ATOM 3335 CD2 PHE B 235 -4. .085 -29. .406 -6. .021 1. .00 26. .93 c

ATOM 3336 CE1 PHE B 235 -5. .899 -27. .732 -4. .752 1. .00 27. .04 c

ATOM 3337 CE2 PHE B 235 -4. .378 -28. .167 -6. .569 1. .00 26. .41 c

ATOM 3338 CZ PHE B 235 -5. .277 -27. .331 -5. .932 1. .00 27. .68 c

ATOM 3339 N GLY B 236 -7. .022 -31. .977 -2. .896 1. .00 28. .24 N

ATOM 3340 CA GLY B 236 -8. .245 -31. .479 -2. .254 1. .00 27. .63 C ATOM 3341 C GLY B 236 -7..833 -30..643 -1..046 1..00 27..05 C

ATOM 3342 O GLY B 236 -6. .656 -30. .639 -0. .669 1. .00 25. .84 O

ATOM 3343 N VAL B 237 -8. .782 -29. .923 -0. .444 1. .00 25. .24 N

ATOM 3344 CA VAL B 237 -8. .482 -29. .094 0. .727 1. .00 23. .94 C

ATOM 3345 C VAL B 237 -9. .629 -29. .151 1. .728 1. .00 24. .44 C

ATOM 3346 O VAL B 237 -10. .794 -29. .076 1. .342 1. .00 24. .79 O

ATOM 3347 CB VAL B 237 -8. .206 -27. .626 0. .331 1. .00 24. .46 C

ATOM 3348 CGI VAL B 237 -7. .798 -26. .784 1. .550 1. .00 23. .44 c

ATOM 3349 CG2 VAL B 237 -7. .136 -27. .537 -0. .754 1. .00 23. .51 c

ATOM 3350 N ASP B 238 -9. .309 -29. .329 3. .009 1. .00 24. .52 N

ATOM 3351 CA ASP B 238 -10. .290 -29. .115 4. .096 1. .00 24. .07 C

ATOM 3352 C ASP B 238 -9. .798 -27. .904 4. .860 1. .00 22. .42 C

ATOM 3353 O ASP B 238 -8. .731 -27. .957 5. .471 1. .00 21. .47 O

ATOM 3354 CB ASP B 238 -10. .348 -30. .293 5. .073 1. .00 26. .86 c

ATOM 3355 CG ASP B 238 -10. .948 -31. .551 4. .471 1. .00 31. .96 c

ATOM 3356 OD1 ASP B 238 -11. .744 -31. .485 3. .507 1. .00 34. .30 0

ATOM 3357 OD2 ASP B 238 -10. .621 -32. .632 4. .993 1. .00 36. .67 0

ATOM 3358 N VAL B 239 -10. .557 -26. .817 4. .802 1. .00 20. .67 N

ATOM 3359 CA VAL B 239 -10. .217 -25. .578 5. .484 1. .00 19. .15 C

ATOM 3360 C VAL B 239 -10. .797 -25. .618 6. .906 1. .00 18. .61 C

ATOM 3361 O VAL B 239 -12. .013 -25. .635 7. .089 1. .00 17. .35 0

ATOM 3362 CB VAL B 239 -10. .801 -24. .359 4. .738 1. .00 20. .18 c

ATOM 3363 CGI VAL B 239 -10. .283 -23. .076 5. .355 1. .00 19. .56 c

ATOM 3364 CG2 VAL B 239 -10. .459 -24. .406 3. .243 1. .00 20. .09 c

ATOM 3365 N GLY B 240 -9. .928 -25. .622 7. .909 1. .00 17. .60 N

ATOM 3366 CA GLY B 240 -10. .382 -25. .611 9. .288 1. .00 17. .57 C

ATOM 3367 C GLY B 240 -10. .856 -24. .242 9. .739 1. .00 17. .30 C

ATOM 3368 O GLY B 240 -10. .564 -23. .235 9. .085 1. .00 17. .29 0

ATOM 3369 N PRO B 241 -11. .614 -24. .200 10. .851 1. .00 17. .59 N

ATOM 3370 CA PRO B 241 -12. .112 -22. .929 11. .375 1. .00 17. .48 C

ATOM 3371 C PRO B 241 -10. .966 -22. .036 11. .824 1. .00 17. .77 C

ATOM 3372 O PRO B 241 -9. .946 -22. .525 12. .315 1. .00 16. .47 O

ATOM 3373 CB PRO B 241 -12. .957 -23. .327 12. .604 1. .00 18. .16 C

ATOM 3374 CG PRO B 241 -13. .117 -24. .818 12. .564 1. .00 18. .64 c

ATOM 3375 CD PRO B 241 -12. .154 -25. .386 11. .557 1. .00 17. .37 c

ATOM 3376 N VAL B 242 -11. .114 -20. .737 11. .630 1. .00 17. .79 N

ATOM 3377 CA VAL B 242 -10. .143 -19. .810 12. .184 1. .00 17. .97 C

ATOM 3378 C VAL B 242 -10. .568 -19. .599 13. .640 1. .00 18. .91 C

ATOM 3379 O VAL B 242 -11. .746 -19. .365 13. .915 1. .00 19. .17 O

ATOM 3380 CB VAL B 242 -10. .046 -18. .507 11. .362 1. .00 17. .77 c

ATOM 3381 CGI VAL B 242 -11. .431 -17. .865 11. .172 1. .00 17. .79 c

ATOM 3382 CG2 VAL B 242 -9. .043 -17. .538 11. .975 1. .00 16. .23 c

ATOM 3383 N CYS B 243 -9. .627 -19. .749 14. .570 1. .00 18. .46 N

ATOM 3384 CA CYS B 243 -9. .962 -19. .740 15. .988 1. .00 19. .36 C

ATOM 3385 C CYS B 243 -9. .260 -18. .573 16. .669 1. .00 20. .15 C

ATOM 3386 O CYS B 243 -8. .019 -18. .490 16. .642 1. .00 19. .46 O

ATOM 3387 CB CYS B 243 -9. .593 -21. .072 16. .678 1. .00 18. .60 c

ATOM 3388 SG CYS B 243 -10. .611 -22. .518 16. .236 1. .00 18. .00 s

ATOM 3389 N PHE B 244 -10. .062 -17. .685 17. .264 1. .00 19. .30 N

ATOM 3390 CA PHE B 244 -9. .546 -16. .501 17. .957 1. .00 20. .35 C

ATOM 3391 C PHE B 244 -9. .663 -16. .631 19. .473 1. .00 21. .44 C

ATOM 3392 O PHE B 244 -10. .677 -17. .109 19. .983 1. .00 22. .40 O

ATOM 3393 CB PHE B 244 -10. .310 -15. .232 17. .525 1. .00 17. .95 c

ATOM 3394 CG PHE B 244 -10. .270 -14. .953 16. .041 1. .00 17. .96 c

ATOM 3395 CD1 PHE B 244 -9. .250 -14. .195 15. .494 1. .00 17. .16 c

ATOM 3396 CD2 PHE B 244 -11. .285 -15. .427 15. .189 1. .00 17. .56 c

ATOM 3397 CE1 PHE B 244 -9. .221 -13. .914 14. .141 1. .00 17. .84 c

ATOM 3398 CE2 PHE B 244 -11. .269 -15. .145 13. .824 1. .00 17. .40 c

ATOM 3399 CZ PHE B 244 -10. .238 -14. .377 13. .296 1. .00 18. .05 c

ATOM 3400 N LEU B 245 -8. .655 -16. .154 20. .193 1. .00 24. .37 N

ATOM 3401 CA LEU B 245 -8. .769 -16. .003 21. .640 1. .00 28. .28 C ATOM 3402 C LEU B 245 -9..044 -14., 530 22., 046 1..00 32., 94 C

ATOM 3403 O LEU B 245 -10. .207 -14. , 075 21. , 989 1. .00 37. , 53 O

ATOM 3404 CB LEU B 245 -7. .539 -16. , 571 22. , 345 1. .00 29. , 96 C

ATOM 3405 CG LEU B 245 -7. .644 -16. , 830 23. , 850 1. .00 31. , 63 C

ATOM 3406 CD1 LEU B 245 -8. .610 -17. , 972 24. , 148 1. .00 34. , 78 C

ATOM 3407 CD2 LEU B 245 -6. .271 -17. , 132 24. , 457 1. .00 32. ,19 C

ATOM 3408 OXT LEU B 245 -8. .169 -13. , 740 22. , 441 1. .00 30. ,71 O

TER 3409 LEU B 245

ATOM 3410 N ILE C 28 -36. .603 0. , 186 23. , 427 1. .00 67. ,89 N

ATOM 3411 CA ILE C 28 -35. .799 1. .428 23. .223 1 , .00 69. .36 C

ATOM 3412 C ILE C 28 -34. .540 1. .162 22. .380 1 , .00 69. .74 C

ATOM 3413 O ILE C 28 -33. .469 1. .716 22. .655 1. .00 72. , 72 O

ATOM 3414 CB ILE C 28 -35. .433 2. .096 24. .571 1 , .00 65. .69 C

ATOM 3415 N SER C 29 -34. .683 0. .314 21. .355 1 , .00 67. .94 N

ATOM 3416 CA SER C 29 -33. .614 0. .027 20. .385 1 , .00 64. .32 C

ATOM 3417 C SER C 29 -33. .132 1. .319 19. .719 1 , .00 62. .59 C

ATOM 3418 O SER C 29 -33. .959 2. .085 19. .214 1 , .00 62. .51 O

ATOM 3419 CB SER C 29 -34. .112 -0. , 959 19. , 318 1. .00 65. , 25 C

ATOM 3420 OG SER C 29 -33. .130 -1. , 184 18. , 317 1. .00 66. , 28 0

ATOM 3421 N PRO C 30 -31. .798 1. .564 19. .717 1 , .00 57. .82 N

ATOM 3422 CA PRO C 30 -31. .213 2. .821 19. .219 1 , .00 52. .98 C

ATOM 3423 C PRO C 30 -31. .768 3. .224 17. .856 1 , .00 48. .57 C

ATOM 3424 O PRO C 30 -31. .938 2. .379 16. .982 1 , .00 49. .73 O

ATOM 3425 CB PRO C 30 -29. .721 2. .495 19. .130 1 , .00 54. .58 C

ATOM 3426 CG PRO C 30 -29. .511 1. .479 20. .203 1 , .00 51. .45 c

ATOM 3427 CD PRO C 30 -30. .750 0. .626 20. .172 1 , .00 55. .71 c

ATOM 3428 N ASP C 31 -32. .064 4. .506 17. .691 1 , .00 44. .13 N

ATOM 3429 CA ASP C 31 -32. .800 4. .967 16. .517 1 , .00 40. .55 C

ATOM 3430 C ASP C 31 -32. .113 6. .044 15. .695 1 , .00 36. .71 C

ATOM 3431 O ASP C 31 -32. .633 6. .452 14. .666 1 , .00 36. .61 O

ATOM 3432 CB ASP C 31 -34. .230 5. .390 16. .895 1 , .00 41. .43 c

ATOM 3433 CG ASP C 31 -34. .282 6. .558 17. .877 1 , .00 43. .32 c

ATOM 3434 OD1 ASP C 31 -33. .234 7. .117 18. .292 1 , .00 43. .68 0

ATOM 3435 OD2 ASP c 31 -35. .419 6. .921 18. .240 1 , .00 46. .07 0

ATOM 3436 N GLY c 32 -30. .942 6. .495 16. .130 1 , .00 34. .48 N

ATOM 3437 CA GLY c 32 -30. .204 7. .508 15. .372 1 , .00 32. .21 C

ATOM 3438 C GLY c 32 -30. .510 8. .935 15. .801 1 , .00 32. .10 C

ATOM 3439 O GLY c 32 -29. .969 9. .883 15. .225 1 , .00 27. .08 0

ATOM 3440 N SER c 33 -31. .368 9. .089 16. .817 1 , .00 32. .19 N

ATOM 3441 CA SER c 33 -31. .552 10. .397 17. .449 1 , .00 35. .33 C

ATOM 3442 C SER c 33 -30. .348 10. .705 18. .344 1 , .00 37. .29 C

ATOM 3443 O SER c 33 -29. .580 9. .798 18. .700 1 , .00 37. .41 O

ATOM 3444 CB SER c 33 -32. .848 10. .453 18. .258 1 , .00 34. .96 C

ATOM 3445 OG SER c 33 -32. .863 9. .472 19. .284 1 , .00 37. .49 0

ATOM 3446 N ARG c 34 -30. .184 11. .981 18. .685 1 , .00 37. .45 N

ATOM 3447 CA ARG c 34 -29. .101 12. , 445 19. , 551 1. .00 39. , 72 C

ATOM 3448 C ARG c 34 -29. .095 11. .724 20. .893 1 , .00 39. .47 C

ATOM 3449 O ARG c 34 -28. .038 11. .435 21. .441 1 , .00 41. .01 O

ATOM 3450 CB ARG c 34 -29. .193 13. .959 19. .778 1. .00 40. , 39 c

ATOM 3451 CG ARG c 34 -27. .904 14. .557 20. .330 1 , .00 42. .89 c

ATOM 3452 CD ARG c 34 -27. .995 16. .066 20. .527 1 , .00 42. .36 c

ATOM 3453 NE ARG c 34 -26. .654 16. .646 20. .574 1 , .00 44. .33 N

ATOM 3454 CZ ARG c 34 -26. .371 17. .937 20. .402 1 , .00 47. .24 C

ATOM 3455 NH1 ARG c 34 -27. .335 18. .826 20. .172 1 , .00 46. .56 N

ATOM 3456 NH2 ARG c 34 -25. .108 18. .340 20. .456 1 , .00 48. .38 N

ATOM 3457 N LYS c 35 -30. .286 11. .441 21. .403 1 , .00 40. .44 N

ATOM 3458 CA LYS c 35 -30. .443 10. .763 22. .675 1 , .00 40. .62 C

ATOM 3459 C LYS c 35 -30. .286 9. .252 22. .547 1 , .00 37. .93 C

ATOM 3460 O LYS c 35 -29. .946 8. .586 23. .523 1 , .00 37. .48 O

ATOM 3461 CB LYS c 35 -31. .796 11. .112 23. .315 1 , .00 43. .27 C

ATOM 3462 CG LYS c 35 -32. .029 12. .612 23. .467 1 , .00 48. .49 C ATOM 3463 CD LYS C 35 -32..795 12..957 24..735 1 ,.00 49..06 C

ATOM 3464 CE LYS C 35 -32. .480 14. .385 25. .156 1 , .00 49. .78 C

ATOM 3465 NZ LYS C 35 -32. .117 14. .429 26. .602 1 , .00 51. .56 N

ATOM 3466 N ASN C 36 -30. .543 8. .709 21. .359 1 , .00 35. .61 N

ATOM 3467 CA ASN C 36 -30. .379 7. .268 21. .150 1 , .00 36. .14 C

ATOM 3468 C ASN C 36 -29. .612 6. .910 19. .884 1 , .00 30. .79 C

ATOM 3469 O ASN C 36 -30. .184 6. , 341 18. , 957 1. .00 28. , 00 O

ATOM 3470 CB ASN C 36 -31. .718 6. .534 21. .230 1 , .00 39. .74 C

ATOM 3471 CG ASN C 36 -31. .836 5. .705 22. .488 1 , .00 48. .81 C

ATOM 3472 OD1 ASN C 36 -31. .188 4. .649 22. .618 1. .00 49. , 68 O

ATOM 3473 ND2 ASN C 36 -32. .648 6. .182 23. .442 1 , .00 48. .17 N

ATOM 3474 N PRO C 37 -28. .312 7. .273 19. .841 1 , .00 28. .72 N

ATOM 3475 CA PRO C 37 -27. .501 7. .073 18. .638 1 , .00 27. .12 C

ATOM 3476 C PRO C 37 -27. .244 5. .594 18. .390 1 , .00 26. .70 C

ATOM 3477 O PRO C 37 -27. .196 4. .818 19. .340 1 , .00 27. .30 O

ATOM 3478 CB PRO C 37 -26. .195 7. .794 18. .968 1 , .00 27. .32 C

ATOM 3479 CG PRO C 37 -26. .121 7. .786 20. .464 1 , .00 28. .02 C

ATOM 3480 CD PRO C 37 -27. .549 7. .949 20. .908 1 , .00 27. .93 C

ATOM 3481 N ALA C 38 -27. .147 5. .213 17. .121 1 , .00 25. .83 N

ATOM 3482 CA ALA C 38 -26. .751 3. .861 16. .741 1 , .00 27. .94 C

ATOM 3483 C ALA C 38 -25. .227 3. .861 16. .680 1 , .00 26. .60 C

ATOM 3484 O ALA C 38 -24. .615 4. .913 16. .817 1 , .00 30. .21 O

ATOM 3485 CB ALA C 38 -27. .372 3. .474 15. .392 1 , .00 25. .75 C

ATOM 3486 N ARG C 39 -24. .610 2. .708 16. .480 1 , .00 26. .62 N

ATOM 3487 CA ARG c 39 -23. .147 2. .646 16. .448 1 , .00 25. .50 C

ATOM 3488 C ARG c 39 -22. .582 3. .287 15. .189 1 , .00 24. .38 C

ATOM 3489 O ARG c 39 -21. .581 4. .011 15. .244 1 , .00 23. .23 O

ATOM 3490 CB ARG c 39 -22. .640 1. .211 16. .597 1 , .00 26. .15 C

ATOM 3491 CG ARG c 39 -21. .127 1. .145 16. .643 1 , .00 26. .35 c

ATOM 3492 CD ARG c 39 -20. .593 -0. , 131 17. ,263 1. .00 26. , 24 c

ATOM 3493 NE ARG c 39 -19. .331 0. .185 17. .945 1 , .00 27. .34 N

ATOM 3494 CZ ARG c 39 -18. .623 -0. , 651 18. , 702 1. .00 27. ,26 C

ATOM 3495 NH1 ARG c 39 -19. .010 -1. , 912 18. , 880 1. .00 24. , 14 N

ATOM 3496 NH2 ARG c 39 -17. .516 -0. , 204 19. ,290 1. .00 26. , 84 N

ATOM 3497 N ASN c 40 -23. .233 3. .007 14. .063 1. .00 22. , 80 N

ATOM 3498 CA ASN c 40 -22. .922 3. .611 12. .788 1 , .00 22. .34 C

ATOM 3499 C ASN c 40 -24. .095 3. .397 11. .859 1 , .00 22. .49 C

ATOM 3500 O ASN c 40 -25. .106 2. .826 12. .252 1 , .00 21. .26 O

ATOM 3501 CB ASN c 40 -21. .638 3. .015 12. .176 1 , .00 23. .04 C

ATOM 3502 CG ASN c 40 -21. .804 1. .573 11. .746 1 , .00 24. .41 C

ATOM 3503 OD1 ASN c 40 -22. .840 0. .942 11. .976 1 , .00 26. .83 O

ATOM 3504 ND2 ASN c 40 -20. .782 1. .040 11. .120 1 , .00 25. .40 N

ATOM 3505 N CYS c 41 -23. .958 3. .834 10. .610 1 , .00 23. .97 N

ATOM 3506 CA CYS c 41 -25. .091 3. .783 9. .704 1 , .00 24. .67 C

ATOM 3507 C CYS c 41 -25. .527 2. .355 9. .350 1 , .00 24. .67 C

ATOM 3508 O CYS c 41 -26. .730 2. .100 9. .273 1 , .00 24. .01 O

ATOM 3509 CB CYS c 41 -24. .870 4. .679 8. .467 1 , .00 24. .98 C

ATOM 3510 SG CYS c 41 -24. .741 6. .451 8. .897 1 , .00 26. .17 S

ATOM 3511 N ARG c 42 -24. .590 1. .427 9. .141 1 , .00 24. .52 N

ATOM 3512 CA ARG c 42 -25. .024 0. .076 8. .816 1 , .00 26. .76 C

ATOM 3513 C ARG c 42 -25. .747 -0. , 556 9. , 985 1. .00 26. , 88 C

ATOM 3514 O ARG c 42 -26. .735 -1. , 240 9. ,790 1. .00 27. , 24 O

ATOM 3515 CB ARG c 42 -23. .913 -0. , 849 8. , 323 1. .00 29. , 87 C

ATOM 3516 CG ARG c 42 -24. .514 -2. ,010 7. , 528 1. .00 32. , 14 c

ATOM 3517 CD ARG c 42 -23. .455 -2. , 908 6. , 952 1. .00 33. , 17 c

ATOM 3518 NE ARG c 42 -22. .491 -3. , 270 7. , 991 1. .00 33. , 83 N

ATOM 3519 CZ ARG c 42 -21. .184 -3. ,463 7. ,796 1. .00 33. , 51 C

ATOM 3520 NH1 ARG c 42 -20. .648 -3. , 329 6. , 594 1. .00 31. ,11 N

ATOM 3521 NH2 ARG c 42 -20. .409 -3. , 779 8. , 826 1. .00 34. , 42 N

ATOM 3522 N ASP c 43 -25. .259 -0. , 304 11. ,192 1. .00 27. , 55 N

ATOM 3523 CA ASP c 43 -25. .879 -0. ,795 12. , 423 1. .00 29. , 82 C ATOM 3524 C ASP C 43 -27..334 -0..285 12..525 1..00 30..04 C

ATOM 3525 O ASP C 43 -28. .259 -1. .057 12. .798 1. .00 30. .54 O

ATOM 3526 CB ASP C 43 -25. .020 -0. .322 13. .605 1. .00 30. .89 C

ATOM 3527 CG ASP C 43 -25. .508 -0. .820 14. .951 1. .00 34. .68 C

ATOM 3528 OD1 ASP C 43 -25. .574 -2. .054 15. .149 1. .00 35. .28 O

ATOM 3529 OD2 ASP C 43 -25. .774 0 , .040 15, .841 1 , .00 35, .29 O

ATOM 3530 N LEU C 44 -27. .526 1 , .009 12 , .271 1 , .00 28 , .35 N

ATOM 3531 CA LEU C 44 -28. .857 1. .615 12. .250 1. .00 29. .19 C

ATOM 3532 C LEU C 44 -29. .730 0 , .975 11 , .174 1 , .00 29, .38 C

ATOM 3533 O LEU C 44 -30. .871 0 , .592 11 , .439 1 , .00 30 , .63 O

ATOM 3534 CB LEU C 44 -28. .760 3, .125 11 , .982 1. .00 27. .98 C

ATOM 3535 CG LEU C 44 -30. .067 3, .922 11 , .922 1 , .00 26, .81 c

ATOM 3536 CD1 LEU C 44 -30. .755 3, .915 13, .280 1 , .00 25, .63 c

ATOM 3537 CD2 LEU C 44 -29. .764 5, .344 11 , .477 1 , .00 27 , .97 c

ATOM 3538 N LYS C 45 -29. .192 0 , .870 9, .963 1 , .00 28 , .95 N

ATOM 3539 CA LYS C 45 -29. .907 0 , .236 8 , .866 1 , .00 32 , .61 C

ATOM 3540 C LYS C 45 -30. .348 -1. .189 9. .249 1. .00 35. .95 C

ATOM 3541 O LYS C 45 -31. .515 -1. .541 9. .108 1. .00 37. .02 O

ATOM 3542 CB LYS C 45 -29. .051 0 , .220 7 , .607 1 , .00 33, .43 c

ATOM 3543 CG LYS C 45 -29. .749 -0. .441 6. .434 1. .00 34. .57 c

ATOM 3544 CD LYS C 45 -28. .833 -0. .581 5. .228 1. .00 33. .84 c

ATOM 3545 CE LYS C 45 -29. .536 -1. .446 4. .195 1. .00 34. .63 c

ATOM 3546 NZ LYS c 45 -28. .997 -1. .202 2. .835 1. .00 36. .99 N

ATOM 3547 N PHE c 46 -29. .418 -1. .989 9. .770 1. .00 35. .78 N

ATOM 3548 CA PHE c 46 -29. .737 -3. .308 10. .309 1. .00 34. .24 C

ATOM 3549 C PHE c 46 -30. .846 -3. .322 11. .372 1. .00 34. .71 C

ATOM 3550 O PHE c 46 -31. .698 -4. .209 11. .374 1. .00 36. .18 O

ATOM 3551 CB PHE c 46 -28. .472 -3. .971 10. .871 1. .00 35. .94 C

ATOM 3552 CG PHE c 46 -28. .062 -5. .208 10. .132 1. .00 35. .00 C

ATOM 3553 CD1 PHE c 46 -28. .713 -6. .406 10. .359 1. .00 33. .73 C

ATOM 3554 CD2 PHE c 46 -27. .040 -5. .170 9. .207 1. .00 35. .55 c

ATOM 3555 CE1 PHE c 46 -28. .349 -7. .554 9. .683 1. .00 34. .54 c

ATOM 3556 CE2 PHE c 46 -26. .673 -6. .313 8. .515 1. .00 34. .43 c

ATOM 3557 CZ PHE c 46 -27. .327 -7. .509 8. .760 1. .00 33. .75 c

ATOM 3558 N CYS c 47 -30. .849 -2. .364 12. .288 1. .00 33. .57 N

ATOM 3559 CA CYS c 47 -31. .857 -2. .413 13. .357 1. .00 33. .92 C

ATOM 3560 C CYS c 47 -33. .178 -1. .721 12. .966 1. .00 34. .10 C

ATOM 3561 O CYS c 47 -34. .227 -2. .035 13. .515 1. .00 35. .24 0

ATOM 3562 CB CYS c 47 -31. .289 -1. .896 14. .688 1. .00 33. .38 c

ATOM 3563 SG CYS c 47 -30. .810 -3. .170 15. .903 1. .00 35. .23 s

ATOM 3564 N HIS c 48 -33. .115 -0. .798 12. .007 1. .00 35. .53 N

ATOM 3565 CA HIS c 48 -34. .305 -0. .107 11. .474 1. .00 35. .15 C

ATOM 3566 C HIS c 48 -34. .223 0 , .038 9, .980 1 , .00 33, .33 C

ATOM 3567 O HIS c 48 -33. .991 1 , .147 9, .468 1 , .00 30 , .65 O

ATOM 3568 CB HIS c 48 -34. .476 1 , .263 12 , .120 1 , .00 34 , .94 c

ATOM 3569 CG HIS c 48 -34. .843 1 , .202 13, .567 1 , .00 36, .01 c

ATOM 3570 ND1 HIS c 48 -33. .956 1 , .436 14 , .541 1 , .00 37 , .75 N

ATOM 3571 CD2 HIS c 48 -36. .050 0 , .903 14 , .195 1 , .00 37 , .60 C

ATOM 3572 CE1 HIS c 48 -34. .556 1 , .301 15, .744 1 , .00 37 , .72 C

ATOM 3573 NE2 HIS c 48 -35. .838 0 , .974 15, .531 1 , .00 38 , .46 N

ATOM 3574 N PRO c 49 -34. .434 -1. .077 9. .248 1. .00 34. .86 N

ATOM 3575 CA PRO c 49 -34. .197 -1. .069 7. .792 1. .00 33. .48 C

ATOM 3576 C PRO c 49 -35. .235 -0. .261 7. .013 1. .00 33. .28 C

ATOM 3577 O PRO c 49 -35. .027 0 , .007 5, .840 1 , .00 33, .87 O

ATOM 3578 CB PRO c 49 -34. .218 -2. .556 7. .415 1. .00 33. .49 C

ATOM 3579 CG PRO c 49 -35. .051 -3. .215 8. .473 1. .00 34. .23 C

ATOM 3580 CD PRO c 49 -35. .060 -2. .338 9. .706 1. .00 35. .30 C

ATOM 3581 N GLU c 50 -36. .318 0 , .159 7 , .663 1. .00 35. .44 N

ATOM 3582 CA GLU c 50 -37. .293 1 , .049 7 , .008 1 , .00 40 , .45 C

ATOM 3583 C GLU c 50 -36. .785 2 , .498 6, .870 1 , .00 41 , .61 C

ATOM 3584 O GLU c 50 -37. .244 3, .224 5, .988 1 , .00 43, .30 O ATOM 3585 CB GLU C 50 -38..657 1..009 7..717 1..00 41..87 C

ATOM 3586 CG GLU C 50 -38. .749 1. .789 9. .028 1. .00 46. .54 C

ATOM 3587 CD GLU C 50 -37. .881 1. .216 10. .151 1. .00 50. .90 C

ATOM 3588 OE1 GLU C 50 -37. .271 0. .130 9. .968 1. .00 48. .13 O

ATOM 3589 OE2 GLU C 50 -37. .815 1. .854 11. .229 1. .00 52. .80 O

ATOM 3590 N LEU C 51 -35. .830 2. .900 7. .719 1. .00 39. .31 N

ATOM 3591 CA LEU C 51 -35. .304 4. .279 7. .722 1. .00 37. .64 C

ATOM 3592 C LEU C 51 -34. .645 4. .673 6. .414 1. .00 37. .91 C

ATOM 3593 O LEU C 51 -33. .922 3. .881 5. .814 1. .00 38. .09 O

ATOM 3594 CB LEU C 51 -34. .305 4. .505 8. .870 1. .00 34. .57 C

ATOM 3595 CG LEU C 51 -34. .889 4. .649 10. .277 1. .00 35. .59 c

ATOM 3596 CD1 LEU C 51 -33. .786 4. .777 11. .323 1. .00 36. .07 c

ATOM 3597 CD2 LEU C 51 -35. .828 5. .841 10. .374 1. .00 35. .50 c

ATOM 3598 N LYS C 52 -34. .884 5. .912 5. .992 1. .00 38. .49 N

ATOM 3599 CA LYS C 52 -34. .285 6. .442 4. .768 1. .00 37. .44 C

ATOM 3600 C LYS C 52 -33. .052 7. .265 5. .056 1. .00 35. .71 C

ATOM 3601 O LYS C 52 -32. .805 7. .685 6. .197 1. .00 34. .63 O

ATOM 3602 CB LYS c 52 -35. .293 7. .293 3. .992 1. .00 42. .21 c

ATOM 3603 CG LYS c 52 -36. .315 6. .466 3. .232 1. .00 47. .02 c

ATOM 3604 CD LYS c 52 -37. .424 7. .334 2. .666 1. .00 51. .22 c

ATOM 3605 CE LYS c 52 -38. .456 6. .479 1. .948 1. .00 55. .73 c

ATOM 3606 NZ LYS c 52 -39. .107 5. , 520 2. , 884 1. , 00 58. , 48 N

ATOM 3607 N SER c 53 -32. .276 7. .477 4. .003 1. .00 34. .88 N

ATOM 3608 CA SER c 53 -31. .072 8. .283 4. .048 1. .00 36. .05 C

ATOM 3609 C SER c 53 -31. .360 9. .659 4. .607 1. .00 37. .34 C

ATOM 3610 O SER c 53 -32. .480 10. .146 4. .505 1. .00 34. .37 O

ATOM 3611 CB SER c 53 -30. .468 8. .417 2. .652 1. .00 33. .29 C

ATOM 3612 OG SER c 53 -30. .243 7. .138 2. .100 1. .00 33. .75 O

ATOM 3613 N GLY c 54 -30. .325 10. .276 5. .179 1. .00 39. .21 N

ATOM 3614 CA GLY c 54 -30. .439 11. .566 5. .843 1. .00 39. .72 C

ATOM 3615 C GLY c 54 -29. .524 11. .651 7. .046 1. .00 40. .45 C

ATOM 3616 O GLY c 54 -28. .621 10. .820 7. .217 1. .00 43. .25 O

ATOM 3617 N GLU c 55 -29. .774 12. .649 7. .889 1. .00 39. .20 N

ATOM 3618 CA GLU c 55 -28. .911 12. , 952 9. , 029 1. , 00 36. , 70 C

ATOM 3619 C GLU c 55 -29. .277 12. .128 10. .231 1. .00 33. .44 C

ATOM 3620 O GLU c 55 -30. .450 12. .051 10. .624 1. .00 31. .28 O

ATOM 3621 CB GLU c 55 -28. .995 14. .431 9. .410 1. , 00 40. , 85 C

ATOM 3622 CG GLU c 55 -28. .513 15. .393 8. .336 1. .00 47. .43 c

ATOM 3623 CD GLU c 55 -27. .004 15. .531 8. .301 1. .00 50. .84 c

ATOM 3624 OE1 GLU c 55 -26. .321 14. .540 7. .966 1. .00 49. .08 0

ATOM 3625 OE2 GLU c 55 -26. .505 16. .638 8. .618 1. .00 56. .40 0

ATOM 3626 N TYR c 56 -28. .267 11. .507 10. .826 1. .00 30. .60 N

ATOM 3627 CA TYR c 56 -28. .497 10. .707 12. .023 1. .00 29. .66 C

ATOM 3628 C TYR c 56 -27. .364 10. .894 13. .011 1. .00 26. .96 C

ATOM 3629 O TYR c 56 -26. .285 11. .341 12. .650 1. .00 26. .42 0

ATOM 3630 CB TYR c 56 -28. .681 9. .226 11. .667 1. .00 28. .68 c

ATOM 3631 CG TYR c 56 -29. .939 8. .922 10. .879 1. .00 29. .05 c

ATOM 3632 CD1 TYR c 56 -31. .148 8. .632 11. .529 1. .00 29. .74 c

ATOM 3633 CD2 TYR c 56 -29. .922 8. .925 9. .489 1. .00 28. .43 c

ATOM 3634 CE1 TYR c 56 -32. .301 8. .355 10. .807 1. .00 29. .59 c

ATOM 3635 CE2 TYR c 56 -31. .055 8. .644 8. .757 1. .00 27. .88 c

ATOM 3636 CZ TYR c 56 -32. .237 8. , 361 9. ,410 1. , 00 30. , 48 c

ATOM 3637 OH TYR c 56 -33. .357 8. .074 8. .658 1. .00 31. .91 0

ATOM 3638 N TRP c 57 -27. .633 10. .598 14. .271 1. .00 27. .35 N

ATOM 3639 CA TRP c 57 -26. .580 10. .584 15. .273 1. , 00 28. ,01 c

ATOM 3640 C TRP c 57 -26. .060 9. .171 15. .415 1. .00 27. .25 c

ATOM 3641 O TRP c 57 -26. .843 8. .234 15. .607 1. .00 27. .30 0

ATOM 3642 CB TRP c 57 -27. .095 11. .154 16. .593 1. .00 31. .07 c

ATOM 3643 CG TRP c 57 -27. .346 12. .648 16. .512 1. .00 32. .81 c

ATOM 3644 CD1 TRP c 57 -28. .466 13. .295 15. .984 1. .00 33. .02 c

ATOM 3645 CD2 TRP c 57 -26. .451 13. .729 16. .944 1. .00 33. .67 c ATOM 3646 NE1 TRP C 57 -28..326 14..662 16..067 1..00 35..43 N

ATOM 3647 CE2 TRP C 57 -27. .149 14. .990 16. .636 1. .00 34. .18 C

ATOM 3648 CE3 TRP C 57 -25. .185 13. .782 17. .541 1. .00 34. .23 C

ATOM 3649 CZ2 TRP C 57 -26. .589 16. .232 16. .922 1. .00 33. .98 C

ATOM 3650 CZ3 TRP C 57 -24. .634 15. .047 17. .830 1. .00 34. .50 C

ATOM 3651 CH2 TRP C 57 -25. .318 16. .238 17. .523 1. .00 33. .95 C

ATOM 3652 N VAL C 58 -24. .744 9. .006 15. .265 1. .00 25. .07 N

ATOM 3653 CA VAL C 58 -24. .082 7. .710 15. .502 1. .00 24. .64 C

ATOM 3654 C VAL C 58 -22. .980 7. .852 16. .540 1. .00 24. .64 C

ATOM 3655 O VAL C 58 -22. .457 8. .952 16. .740 1. .00 25. .88 O

ATOM 3656 CB VAL C 58 -23. .526 7. .059 14. .207 1. .00 22. .75 C

ATOM 3657 CGI VAL C 58 -24. .642 6. .846 13. .181 1. .00 22. .05 c

ATOM 3658 CG2 VAL C 58 -22. .415 7. .894 13. .609 1. .00 21. .83 c

ATOM 3659 N ASP C 59 -22. .623 6. .740 17. .184 1. .00 23. .82 N

ATOM 3660 CA ASP C 59 -21. .665 6. .755 18. .293 1. .00 23. .02 C

ATOM 3661 C ASP c 59 -20. .692 5. .569 18. .201 1. .00 21. .82 C

ATOM 3662 O ASP c 59 -20. .829 4. .583 18. .935 1. .00 21. .54 O

ATOM 3663 CB ASP c 59 -22. .423 6. .723 19. .633 1. .00 22. .68 c

ATOM 3664 CG ASP c 59 -21. .513 6. , 991 20. ,813 1. , 00 23. , 51 c

ATOM 3665 OD1 ASP c 59 -20. .522 7. .719 20. .625 1. .00 24. .37 0

ATOM 3666 OD2 ASP c 59 -21. .775 6. .483 21. .927 1. .00 24. .95 0

ATOM 3667 N PRO c 60 -19. .718 5. .656 17. .292 1. , 00 21. , 04 N

ATOM 3668 CA PRO c 60 -18. .875 4. .503 16. .975 1. .00 21. .32 C

ATOM 3669 C PRO c 60 -18. .167 3. .895 18. .189 1. .00 23. .42 C

ATOM 3670 O PRO c 60 -18. .054 2. .669 18. .285 1. .00 22. .88 0

ATOM 3671 CB PRO c 60 -17. .846 5. .067 15. .984 1. .00 21. .18 c

ATOM 3672 CG PRO c 60 -18. .447 6. .312 15. .434 1. .00 21. .52 c

ATOM 3673 CD PRO c 60 -19. .478 6. .807 16. .400 1. .00 20. .67 c

ATOM 3674 N ASN c 61 -17. .633 4. .726 19. .059 1. .00 24. .03 N

ATOM 3675 CA ASN c 61 -16. .982 4. .271 20. .256 1. .00 23. .90 C

ATOM 3676 C ASN c 61 -17. .901 3. .749 21. .347 1. .00 24. .29 C

ATOM 3677 O ASN c 61 -17. .441 3. .283 22. .304 1. .00 24. .17 0

ATOM 3678 CB ASN c 61 -16. .040 5. .352 20. .815 1. .00 23. .46 c

ATOM 3679 CG ASN c 61 -16. .760 6. .549 21. .453 1. .00 23. .29 c

ATOM 3680 OD1 ASN c 61 -17. .933 6. .565 21. .659 1. .00 22. .52 0

ATOM 3681 ND2 ASN c 61 -16. .002 7. .523 21. .795 1. .00 22. .22 N

ATOM 3682 N GLN c 62 -19. .207 3. .914 21. .194 1. .00 25. .09 N

ATOM 3683 CA GLN c 62 -20. .183 3. .435 22. .180 1. .00 25. .40 C

ATOM 3684 C GLN c 62 -19. .958 3. .981 23. .606 1. .00 25. .77 C

ATOM 3685 O GLN c 62 -19. .604 5. .130 23. .767 1. .00 25. .78 O

ATOM 3686 CB GLN c 62 -20. .286 1. .905 22. .160 1. .00 24. .17 C

ATOM 3687 CG GLN c 62 -20. .746 1. .330 20. .832 1. .00 24. .20 C

ATOM 3688 CD GLN c 62 -22. .229 1. .530 20. .569 1. .00 24. .24 C

ATOM 3689 OE1 GLN c 62 -23. .041 0. .677 20. .879 1. .00 22. .46 0

ATOM 3690 NE2 GLN c 62 -22. .577 2. .661 19. .987 1. .00 23. .89 N

ATOM 3691 N GLY c 63 -20. .138 3. .155 24. .632 1. .00 27. .56 N

ATOM 3692 CA GLY c 63 -20. .026 3. .657 26. .005 1. .00 29. .44 C

ATOM 3693 C GLY c 63 -20. .913 4. .879 26. .173 1. .00 29. .48 C

ATOM 3694 O GLY c 63 -22. .086 4. .845 25. .792 1. .00 29. .56 O

ATOM 3695 N CYS c 64 -20. .348 5. .962 26. .711 1. .00 31. .16 N

ATOM 3696 CA CYS c 64 -21. .078 7. .228 26. .899 1. .00 31. .73 C

ATOM 3697 C CYS c 64 -21. .729 7. .725 25. .591 1. .00 33. .27 C

ATOM 3698 O CYS c 64 -21. .050 7. .880 24. .560 1. .00 33. .55 O

ATOM 3699 CB CYS c 64 -20. .151 8. .299 27. .486 1. .00 33. .62 C

ATOM 3700 SG CYS c 64 -20. .937 9. .854 28. .021 1. .00 33. .77 s

ATOM 3701 N LYS c 65 -23. .039 7. , 970 25. , 642 1. , 00 33. ,76 N

ATOM 3702 CA LYS c 65 -23. .792 8. .488 24. .486 1. .00 35. .40 C

ATOM 3703 C LYS c 65 -23. .504 9. .963 24. .159 1. .00 33. .75 C

ATOM 3704 O LYS c 65 -23. .820 10. .424 23. .057 1. , 00 33. , 92 O

ATOM 3705 CB LYS c 65 -25. .308 8. .314 24. .686 1. .00 38. .86 C

ATOM 3706 CG LYS c 65 -25. .753 6. .952 25. .205 1. .00 42. .84 c ATOM 3707 CD LYS C 65 -27..272 6..872 25..263 1..00 46..67 C

ATOM 3708 CE LYS C 65 -27. .772 5. .958 26. .377 1. .00 51. .09 C

ATOM 3709 NZ LYS C 65 -27. .472 4. .516 26. .134 1. .00 52. .01 N

ATOM 3710 N LEU C 66 -22. .904 10. .695 25. .096 1. .00 31. .02 N

ATOM 3711 CA LEU C 66 -22. .769 12. .157 24. .966 1. .00 31. .32 C

ATOM 3712 C LEU C 66 -21. .754 12. .650 23. .918 1. .00 30. .51 C

ATOM 3713 O LEU C 66 -21. .812 13. .803 23. .486 1. .00 32. .26 O

ATOM 3714 CB LEU C 66 -22. .497 12. .809 26. .328 1. .00 31. .07 C

ATOM 3715 CG LEU C 66 -23. .465 12. .526 27. .485 1. .00 33. .16 C

ATOM 3716 CD1 LEU C 66 -22. .960 13. .214 28. .746 1. .00 34. .30 C

ATOM 3717 CD2 LEU C 66 -24. .894 12. .959 27. .185 1. .00 32. .55 C

ATOM 3718 N ASP C 67 -20. .837 11. .795 23. .486 1. .00 28. .26 N

ATOM 3719 CA ASP C 67 -19. .907 12. , 231 22. , 437 1. , 00 27. ,19 C

ATOM 3720 C ASP C 67 -20. .320 11. .751 21. .045 1. .00 26. .47 C

ATOM 3721 O ASP C 67 -19. .465 11. .647 20. .157 1. .00 25. .05 O

ATOM 3722 CB ASP C 67 -18. .472 11. .785 22. .738 1. , 00 27. , 53 C

ATOM 3723 CG ASP C 67 -18. .339 10. .260 22. .875 1. .00 28. .68 c

ATOM 3724 OD1 ASP C 67 -19. .351 9. .521 22. .722 1. .00 28. .00 0

ATOM 3725 OD2 ASP c 67 -17. .213 9. .793 23. .164 1. .00 28. .12 0

ATOM 3726 N ALA c 68 -21. .617 11. .478 20. .844 1. .00 25. .64 N

ATOM 3727 CA ALA c 68 -22. .095 11. .021 19. .524 1. .00 25. .34 C

ATOM 3728 C ALA c 68 -21. .825 12. .074 18. .472 1. .00 26. .00 C

ATOM 3729 O ALA c 68 -21. .678 13. .254 18. .791 1. .00 26. .46 O

ATOM 3730 CB ALA c 68 -23. .566 10. .667 19. .556 1. .00 23. .75 c

ATOM 3731 N ILE c 69 -21. .727 11. .632 17. .223 1. .00 26. .51 N

ATOM 3732 CA ILE c 69 -21. .481 12. .513 16. .094 1. .00 26. .53 C

ATOM 3733 C ILE c 69 -22. .656 12. .466 15. .123 1. .00 27. .52 C

ATOM 3734 O ILE c 69 -23. .306 11. .428 14. .947 1. .00 27. .54 O

ATOM 3735 CB ILE c 69 -20. .173 12. .163 15. .339 1. .00 27. .21 c

ATOM 3736 CGI ILE c 69 -20. .143 10. .686 14. .895 1. .00 25. .25 c

ATOM 3737 CG2 ILE c 69 -18. .955 12. .491 16. .198 1. .00 28. .48 c

ATOM 3738 CD1 ILE c 69 -19. .002 10. .381 13. .950 1. .00 23. .98 c

ATOM 3739 N LYS c 70 -22. .925 13. .600 14. .498 1. .00 28. .75 N

ATOM 3740 CA LYS c 70 -24. .011 13. .710 13. .557 1. .00 30. .49 C

ATOM 3741 C LYS c 70 -23. .420 13. .398 12. .204 1. .00 30. .25 C

ATOM 3742 O LYS c 70 -22. .385 13. .943 11. .834 1. .00 29. .89 O

ATOM 3743 CB LYS c 70 -24. .593 15. .118 13. .589 1. .00 33. .19 c

ATOM 3744 CG LYS c 70 -25. .953 15. .279 12. .920 1. .00 36. .97 c

ATOM 3745 CD LYS c 70 -26. .532 16. .636 13. .312 1. .00 40. .32 c

ATOM 3746 CE LYS c 70 -27. .662 17. .102 12. .406 1. .00 45. .52 c

ATOM 3747 NZ LYS c 70 -27. .894 18. , 573 12. , 578 1. , 00 46. , 93 N

ATOM 3748 N VAL c 71 -24. .057 12. .482 11. .483 1. .00 29. .18 N

ATOM 3749 CA VAL c 71 -23. .553 12. .071 10. .190 1. .00 30. .14 C

ATOM 3750 C VAL c 71 -24. .687 11. .977 9. .187 1. , 00 29. , 73 C

ATOM 3751 O VAL c 71 -25. .875 12. .046 9. .545 1. .00 30. .06 O

ATOM 3752 CB VAL c 71 -22. .836 10. .690 10. .259 1. .00 29. .06 C

ATOM 3753 CGI VAL c 71 -21. .750 10. .680 11. .335 1. .00 28. .99 C

ATOM 3754 CG2 VAL c 71 -23. .844 9. .581 10. .496 1. .00 27. .62 C

ATOM 3755 N PHE c 72 -24. .296 11. .775 7. .938 1. .00 29. .83 N

ATOM 3756 CA PHE c 72 -25. .220 11. .389 6. .896 1. .00 30. .37 C

ATOM 3757 C PHE c 72 -25. .155 9. .878 6. .626 1. .00 28. .33 C

ATOM 3758 O PHE c 72 -24. .102 9. .334 6. .312 1. .00 27. .59 O

ATOM 3759 CB PHE c 72 -24. .936 12. .175 5. .616 1. .00 30. .94 C

ATOM 3760 CG PHE c 72 -25. .830 11. .792 4. .466 1. .00 33. .24 c

ATOM 3761 CD1 PHE c 72 -27. .126 12. .306 4. .373 1. .00 35. .08 c

ATOM 3762 CD2 PHE c 72 -25. .379 10. .909 3. .480 1. .00 33. .28 c

ATOM 3763 CE1 PHE c 72 -27. .953 11. .946 3. .314 1. .00 35. .18 c

ATOM 3764 CE2 PHE c 72 -26. .201 10. .546 2. .429 1. .00 35. .20 c

ATOM 3765 CZ PHE c 72 -27. .491 11. .064 2. .348 1. .00 35. .92 c

ATOM 3766 N CYS c 73 -26. .297 9. .218 6. .756 1. .00 29. .06 N

ATOM 3767 CA CYS c 73 -26. .407 7. .791 6. .501 1. .00 28. .83 C ATOM 3768 C CYS C 73 -27..032 7..623 5..134 1..00 30..21 C

ATOM 3769 O CYS C 73 -28. .170 8. .030 4. .929 1. .00 29. .38 O

ATOM 3770 CB CYS C 73 -27. .310 7. .134 7. .539 1. .00 27. .80 C

ATOM 3771 SG CYS C 73 -26. .652 7. .048 9. .211 1. .00 25. .08 S

ATOM 3772 N ASN C 74 -26. .269 7. .073 4. .197 1. .00 31. .76 N

ATOM 3773 CA ASN C 74 -26. .821 6. .582 2. .940 1. .00 34. .62 C

ATOM 3774 C ASN C 74 -27. .439 5. .202 3. .184 1. .00 34. .55 C

ATOM 3775 O ASN C 74 -26. .716 4. , 203 3. ,260 1. , 00 35. , 08 O

ATOM 3776 CB ASN C 74 -25. .726 6. .507 1. .861 1. .00 34. .78 C

ATOM 3777 CG ASN C 74 -26. .208 5. .838 0. .562 1. .00 38. .37 c

ATOM 3778 OD1 ASN C 74 -27. .260 5. .191 0. .516 1. .00 39. .65 0

ATOM 3779 ND2 ASN C 74 -25. .419 5. .983 -0. ,495 1. , 00 38. , 92 N

HETATM 3780 N MSE C 75 -28. .764 5. .158 3. .321 1. .00 34. .51 N

HETATM 3781 CA MSE C 75 -29. .468 3. .930 3. .725 1. .00 37. .75 C

HETATM 3782 C MSE C 75 -29. .630 2. .916 2. .623 1. .00 38. .12 C

HETATM 3783 O MSE C 75 -30. .105 1. .811 2. .866 1. .00 41. .74 O

HETATM 3784 CB MSE C 75 -30. .804 4. .219 4. .415 1. .00 38. .42 C

HETATM 3785 CG MSE C 75 -30. .598 4. .953 5. .738 1. .00 43. .35 C

HETATM 3786 SE MSE c 75 -29. .534 3. .934 7. .074 1. .00 50. .39 SE

HETATM 3787 CE MSE c 75 -27. .740 4. , 030 6. , 300 1. , 00 44. , 61 C

ATOM 3788 N GLU c 76 -29. .234 3. .266 1. .408 1. .00 40. .51 N

ATOM 3789 CA GLU c 76 -29. .194 2. .290 0. .321 1. .00 42. .26 C

ATOM 3790 C GLU c 76 -27. .955 1. .414 0. .502 1. , 00 44. , 74 C

ATOM 3791 O GLU c 76 -28. .069 0. .186 0. .560 1. .00 44. .38 O

ATOM 3792 CB GLU c 76 -29. .191 2. .976 -1. , 049 1. , 00 39. , 50 C

ATOM 3793 N THR c 77 -26. .789 2. .053 0. .645 1. .00 44. .00 N

ATOM 3794 CA THR c 77 -25. .510 1. .339 0. .740 1. .00 43. .80 C

ATOM 3795 C THR c 77 -25. .055 1. .025 2. .163 1. .00 40. .76 C

ATOM 3796 O THR c 77 -24. .179 0. .191 2. .358 1. .00 43. .09 O

ATOM 3797 CB THR c 77 -24. .367 2. .111 0. .051 1. .00 44. .68 C

ATOM 3798 OG1 THR c 77 -24. .053 3. .278 0. .820 1. .00 45. .11 0

ATOM 3799 CG2 THR c 77 -24. .775 2. .521 -1. , 349 1. , 00 45. , 14 c

ATOM 3800 N GLY c 78 -25. .634 1. .702 3. .145 1. .00 40. .22 N

ATOM 3801 CA GLY c 78 -25. .210 1. .564 4. .534 1. .00 36. .37 C

ATOM 3802 C GLY c 78 -24. .008 2. , 408 4. , 955 1. , 00 33. , 80 C

ATOM 3803 O GLY c 78 -23. .543 2. .300 6. .094 1. .00 30. .52 O

ATOM 3804 N GLU c 79 -23. .503 3. .244 4. .052 1. .00 32. .87 N

ATOM 3805 CA GLU c 79 -22. .350 4. .097 4. .354 1. , 00 32. , 56 C

ATOM 3806 C GLU c 79 -22. .597 5. .117 5. .458 1. .00 31. .64 C

ATOM 3807 O GLU c 79 -23. .669 5. .719 5. .532 1. .00 32. .37 O

ATOM 3808 CB GLU c 79 -21. .910 4. .858 3. .123 1. .00 33. .62 C

ATOM 3809 CG GLU c 79 -21. .146 4. .038 2. .106 1. .00 36. .66 c

ATOM 3810 CD GLU c 79 -21. .041 4. .764 0. .787 1. .00 36. .89 c

ATOM 3811 OE1 GLU c 79 -22. .107 5. .081 0. .212 1. .00 39. .49 0

ATOM 3812 OE2 GLU c 79 -19. .909 5. .023 0. .340 1. .00 35. .95 0

ATOM 3813 N THR c 80 -21. .576 5. .318 6. .289 1. .00 29. .12 N

ATOM 3814 CA THR c 80 -21. .541 6. .406 7. .263 1. .00 28. .14 C

ATOM 3815 C THR c 80 -20. .673 7. .523 6. .676 1. .00 27. .85 C

ATOM 3816 O THR c 80 -19. .531 7. .292 6. .305 1. .00 27. .21 0

ATOM 3817 CB THR c 80 -20. .986 5. .933 8. .625 1. .00 26. .22 c

ATOM 3818 OG1 THR c 80 -21. .828 4. .893 9. .140 1. .00 26. .07 0

ATOM 3819 CG2 THR c 80 -20. .953 7. .087 9. .646 1. .00 25. .86 c

ATOM 3820 N CYS c 81 -21. .237 8. .719 6. .564 1. .00 28. .42 N

ATOM 3821 CA CYS c 81 -20. .556 9. .831 5. .897 1. .00 29. .08 C

ATOM 3822 C CYS c 81 -20. .408 11. .035 6. .833 1. .00 27. .99 C

ATOM 3823 O CYS c 81 -21. .395 11. .567 7. .337 1. .00 27. .83 0

ATOM 3824 CB CYS c 81 -21. .291 10. .198 4. .588 1. .00 29. .94 c

ATOM 3825 SG CYS c 81 -21. .288 8. .862 3. .339 1. .00 31. .87 s

ATOM 3826 N ILE c 82 -19. .170 11. .422 7. .071 1. .00 29. .45 N

ATOM 3827 CA ILE c 82 -18. .858 12. .568 7. .903 1. .00 32. .63 C

ATOM 3828 C ILE c 82 -18. .408 13. .773 7. .077 1. .00 32. .30 C ATOM 3829 O ILE C 82 -17..452 13..715 6..345 1 ,.00 29..98 O

ATOM 3830 CB ILE C 82 -17. .761 12. , 232 8. , 921 1. .00 32. , 24 C

ATOM 3831 CGI ILE C 82 -18. .107 10. .969 9. .674 1 , .00 33. .65 C

ATOM 3832 CG2 ILE C 82 -17. .601 13. .341 9. .920 1 , .00 32. .45 C

ATOM 3833 CD1 ILE C 82 -16. .906 10. .262 10. .209 1. .00 34. ,01 C

ATOM 3834 N SER C 83 -19. .142 14. .859 7. .228 1 , .00 35. .15 N

ATOM 3835 CA SER C 83 -18. .884 16. .115 6. .546 1 , .00 36. .44 C

ATOM 3836 C SER C 83 -17. .659 16. .815 7. .088 1 , .00 37. .98 C

ATOM 3837 O SER C 83 -17. .366 16. .736 8. .254 1 , .00 35. .64 O

ATOM 3838 CB SER C 83 -20. .068 17. .054 6. .712 1 , .00 37. .51 C

ATOM 3839 OG SER C 83 -21. .189 16. .659 5. .973 1 , .00 39. .28 O

ATOM 3840 N ALA C 84 -16. .963 17. .512 6. .214 1 , .00 40. .00 N

ATOM 3841 CA ALA C 84 -15. .937 18. .457 6. .597 1 , .00 42. .21 C

ATOM 3842 C ALA C 84 -16. .504 19. .738 7. .189 1 , .00 42. .31 C

ATOM 3843 O ALA C 84 -17. .605 20. .138 6. .892 1 , .00 41. .44 O

ATOM 3844 CB ALA C 84 -15. .047 18. .773 5. .422 1 , .00 41. .35 C

ATOM 3845 N ASN C 85 -15. .732 20. .256 8. .129 1 , .00 46. .95 N

ATOM 3846 CA ASN c 85 -15. .954 21. .543 8. .723 1 , .00 49. .58 C

ATOM 3847 C ASN c 85 -14. .658 22. .293 8. .751 1 , .00 51. .16 C

ATOM 3848 O ASN c 85 -13. .794 21. .984 9. .534 1 , .00 54. .50 O

ATOM 3849 CB ASN c 85 -16. .456 21. .371 10. .138 1 , .00 51. .82 C

ATOM 3850 CG ASN c 85 -17. .942 21. .594 10. .251 1 , .00 57. .02 c

ATOM 3851 OD1 ASN c 85 -18. .390 22. .664 10. .649 1 , .00 59. .69 0

ATOM 3852 ND2 ASN c 85 -18. .716 20. .595 9. .877 1 , .00 54. .86 N

ATOM 3853 N PRO c 86 -14. .534 23. .322 7. .936 1 , .00 50. .45 N

ATOM 3854 CA PRO c 86 -15. .553 23. .742 6. .974 1 , .00 48. .60 C

ATOM 3855 C PRO c 86 -15. .767 22. .857 5. .737 1 , .00 48. .45 C

ATOM 3856 O PRO c 86 -14. .922 22. .098 5. .318 1 , .00 46. .46 O

ATOM 3857 CB PRO c 86 -15. .059 25. .114 6. .548 1 , .00 48. .40 C

ATOM 3858 CG PRO c 86 -13. .605 25. , 129 6. ,868 1. .00 48. , 55 C

ATOM 3859 CD PRO c 86 -13. .236 23. .937 7. .666 1 , .00 48. .17 C

ATOM 3860 N LEU c 87 -16. .953 22. .982 5. .172 1 , .00 51. .26 N

ATOM 3861 CA LEU c 87 -17. .341 22. .279 3. .953 1 , .00 52. .08 C

ATOM 3862 C LEU c 87 -16. .490 22. .637 2. .739 1 , .00 51. .38 C

ATOM 3863 O LEU c 87 -16. .148 21. .764 1. .930 1 , .00 47. .89 O

ATOM 3864 CB LEU c 87 -18. .816 22. .569 3. .630 1 , .00 53. .01 C

ATOM 3865 CG LEU c 87 -19. .895 21. .656 4. .229 1 , .00 57. .03 c

ATOM 3866 CD1 LEU c 87 -21. .265 22. .321 4. .174 1 , .00 56. .11 c

ATOM 3867 CD2 LEU c 87 -19. .920 20. .298 3. .530 1 , .00 56. .85 c

ATOM 3868 N ASN c 88 -16. .175 23. .924 2. .600 1 , .00 54. .40 N

ATOM 3869 CA ASN c 88 -15. .515 24. .405 1. .390 1 , .00 55. .88 C

ATOM 3870 C ASN c 88 -14. .408 25. , 420 1. , 581 1. .00 54. , 52 C

ATOM 3871 O ASN c 88 -14. .381 26. .170 2. .560 1 , .00 57. .73 O

ATOM 3872 CB ASN c 88 -16. .534 24. .892 0. .340 1 , .00 59. .03 c

ATOM 3873 CG ASN c 88 -17. .312 26. .108 0. .786 1. .00 64. ,06 c

ATOM 3874 OD1 ASN c 88 -18. .016 26. .073 1. .799 1 , .00 69. .86 0

ATOM 3875 ND2 ASN c 88 -17. .210 27. .191 0. .015 1 , .00 63. .48 N

ATOM 3876 N VAL c 89 -13. .479 25. .398 0. .634 1 , .00 50. .97 N

ATOM 3877 CA VAL c 89 -12. .515 26. .465 0. .445 1 , .00 50. .22 C

ATOM 3878 C VAL c 89 -13. .147 27. .435 -0. , 572 1. .00 51. , 17 C

ATOM 3879 O VAL c 89 -13. .520 27. .014 -1. , 676 1. .00 49. , 28 O

ATOM 3880 CB VAL c 89 -11. .178 25. .892 -0. , 071 1. .00 48. , 85 C

ATOM 3881 CGI VAL c 89 -10. .173 27. .002 -0. , 368 1. .00 48. , 85 C

ATOM 3882 CG2 VAL c 89 -10. .615 24. .884 0. .926 1 , .00 46. .10 C

ATOM 3883 N PRO c 90 -13. .305 28. .727 -0. ,198 1. .00 51. , 25 N

ATOM 3884 CA PRO c 90 -13. .948 29. .686 -1. , 122 1. .00 52. , 66 C

ATOM 3885 C PRO c 90 -13. .091 29. .993 -2. , 353 1. .00 50. ,06 C

ATOM 3886 O PRO c 90 -11. .867 29. .842 -2. , 304 1. .00 47. , 72 O

ATOM 3887 CB PRO c 90 -14. .131 30. .953 -0. ,269 1. .00 52. ,16 C

ATOM 3888 CG PRO c 90 -13. .939 30. , 520 1. , 149 1. .00 52. , 75 c

ATOM 3889 CD PRO c 90 -13. .011 29. .338 1. .111 1 , .00 52. .69 c ATOM 3890 N ARG C 91 -13..739 30..411 -3..440 1..00 49..19 N

ATOM 3891 CA ARG C 91 -13. .040 30. .760 -4. .682 1. .00 53. .84 C

ATOM 3892 C ARG C 91 -12. .205 32. .032 -4. .500 1. .00 55. .52 C

ATOM 3893 O ARG C 91 -12. .750 33. .134 -4. .396 1. .00 58. .92 O

ATOM 3894 CB ARG C 91 -14. .030 30. .942 -5. .841 1. .00 52. .70 C

ATOM 3895 CG ARG C 91 -14. .760 29. .679 -6. .277 1. .00 53. .67 c

ATOM 3896 CD ARG C 91 -15. .663 29. .963 -7. .467 1. .00 54. .15 c

ATOM 3897 NE ARG C 91 -16. .295 28. .749 -7. .984 1. .00 56. .94 N

ATOM 3898 CZ ARG C 91 -17. .015 28. .680 -9. .106 1. .00 58. .26 C

ATOM 3899 NH1 ARG C 91 -17. .202 29. .754 -9. .866 1. .00 55. .00 N

ATOM 3900 NH2 ARG C 91 -17. .550 27. .525 -9. .476 1. .00 57. .91 N

ATOM 3901 N LYS C 92 -10. .886 31. .874 -4. .450 1. .00 54. .45 N

ATOM 3902 CA LYS C 92 -9. .981 33. .012 -4. .264 1. .00 57. .08 C

ATOM 3903 C LYS C 92 -8. .686 32. .861 -5. .054 1. .00 56. .21 C

ATOM 3904 O LYS C 92 -8. .283 31. .749 -5. .423 1. .00 50. .89 O

ATOM 3905 CB LYS C 92 -9. .637 33. .235 -2. .778 1. .00 56. .51 C

ATOM 3906 CG LYS C 92 -10. .777 33. .738 -1. .898 1. .00 60. .60 C

ATOM 3907 CD LYS C 92 -10. .351 34. .919 -1. .031 1. .00 62. .46 C

ATOM 3908 CE LYS C 92 -9. .210 34. .576 -0. .074 1. .00 64. .01 C

ATOM 3909 NZ LYS C 92 -8. .464 35. .801 0 , .342 1 , .00 62 , .96 N

ATOM 3910 N PHE c 93 -8. .053 34. .002 -5. .317 1. .00 58. .17 N

ATOM 3911 CA PHE c 93 -6. .664 34. .050 -5. .747 1. .00 58. .99 C

ATOM 3912 C PHE c 93 -5. .820 33. .742 -4. .502 1. .00 59. .85 C

ATOM 3913 O PHE c 93 -5. .350 34. .654 -3. .804 1. .00 59. .02 O

ATOM 3914 CB PHE c 93 -6. .354 35. .430 -6. .345 1. .00 63. .53 C

ATOM 3915 CG PHE c 93 -4. .910 35. .632 -6. .707 1. .00 67. .24 C

ATOM 3916 CD1 PHE c 93 -4. .387 35. , 076 -7. .868 1. .00 65. .69 C

ATOM 3917 CD2 PHE c 93 -4. .070 36. .386 -5. .884 1. .00 68. .20 C

ATOM 3918 CE1 PHE c 93 -3. .057 35. .256 -8. .194 1. .00 67. .22 C

ATOM 3919 CE2 PHE c 93 -2. .738 36. .571 -6. .209 1. .00 69. .49 c

ATOM 3920 CZ PHE c 93 -2. .234 36. .008 -7. .371 1. .00 68. .15 c

ATOM 3921 N TRP c 94 -5. .664 32. .446 -4. .218 1. .00 56. .21 N

ATOM 3922 CA TRP c 94 -5. .081 31. .972 -2. .957 1. .00 55. .72 C

ATOM 3923 C TRP c 94 -3. .589 32. .107 -2. .888 1. .00 58. .30 C

ATOM 3924 O TRP c 94 -3. .026 32. .329 -1. .813 1. .00 58. .92 O

ATOM 3925 CB TRP c 94 -5. .456 30. .512 -2. .712 1. .00 52. .18 c

ATOM 3926 CG TRP c 94 -6. .870 30. .332 -2. .229 1. .00 50. .49 c

ATOM 3927 CD1 TRP c 94 -7. .956 29. .844 -2. .947 1. .00 48. .13 c

ATOM 3928 CD2 TRP c 94 -7. .401 30. .642 -0. .892 1. .00 49. .91 c

ATOM 3929 NE1 TRP c 94 -9. .085 29. .828 -2. .177 1. .00 48. .65 N

ATOM 3930 CE2 TRP c 94 -8. .827 30. .291 -0. .929 1. .00 50. .19 C

ATOM 3931 CE3 TRP c 94 -6. .858 31. .155 0 , .290 1 , .00 48 , .33 C

ATOM 3932 CZ2 TRP c 94 -9. .661 30. .460 0 , .180 1 , .00 48 , .07 c

ATOM 3933 CZ3 TRP c 94 -7. .705 31. .317 1 , .399 1 , .00 49 , .88 c

ATOM 3934 CH2 TRP c 94 -9. .074 30. .975 1 , .342 1 , .00 47 , .99 c

ATOM 3935 N TRP c 95 -2. .939 31. .962 -4. .038 1. .00 56. .31 N

ATOM 3936 CA TRP c 95 -1. .495 31. .851 -4. .093 1. .00 56. .58 C

ATOM 3937 C TRP c 95 -0. .924 32. .748 -5. .152 1. .00 59. .04 C

ATOM 3938 O TRP c 95 -1. .439 32. .810 -6. .282 1. .00 54. .81 O

ATOM 3939 CB TRP c 95 -1. .124 30. .408 -4. .382 1. .00 55. .37 c

ATOM 3940 CG TRP c 95 0. .348 30. .111 -4. .273 1. .00 56. .03 c

ATOM 3941 CD1 TRP c 95 1. .233 29. .810 -5. .306 1. .00 55. .74 c

ATOM 3942 CD2 TRP c 95 1. .159 30. .063 -3. .045 1. .00 56. .03 c

ATOM 3943 NE1 TRP c 95 2. .499 29. .584 -4. .820 1. .00 58. .99 N

ATOM 3944 CE2 TRP c 95 2. .527 29. ,719 -3. .473 1. .00 57. .66 C

ATOM 3945 CE3 TRP c 95 0. .901 30. .261 -1. .688 1. .00 54. .51 C

ATOM 3946 CZ2 TRP c 95 3. .574 29. .586 -2. .564 1. .00 56. .34 c

ATOM 3947 CZ3 TRP c 95 1. .962 30. .118 -0. .783 1. .00 56. .57 c

ATOM 3948 CH2 TRP c 95 3. .266 29. .787 -1. .212 1. .00 56. .84 c

ATOM 3949 N THR c 96 0. .156 33. .455 -4. .834 1. .00 62. .84 N

ATOM 3950 CA THR c 96 0. .830 34. .286 -5. .839 1. .00 67. .83 C ATOM 3951 C THR C 96 2..292 33..895 -6..108 1..00 71..59 C

ATOM 3952 O THR C 96 3. .160 34. .012 -5. .258 1. .00 74. .74 O

ATOM 3953 CB THR C 96 0. .617 35. .798 -5. .595 1. .00 67. .89 C

ATOM 3954 OG1 THR C 96 1. .530 36. .567 -6. .383 1. .00 69. .28 O

ATOM 3955 CG2 THR C 96 0. .764 36. .152 -4. .149 1. .00 68. .42 C

ATOM 3956 N ASP C 97 2. .523 33. ,414 -7. .321 1. .00 74. .07 N

ATOM 3957 CA ASP C 97 3. .752 32. .760 -7. .771 1. .00 76. .05 C

ATOM 3958 C ASP C 97 4. .497 31. .939 -6. .740 1. .00 76. .43 C

ATOM 3959 O ASP C 97 5. .322 31. .093 -7. .100 1. .00 74. .93 O

ATOM 3960 CB ASP C 97 4. .703 33. .731 -8. .474 1. .00 82. .46 C

ATOM 3961 CG ASP C 97 4. .187 34. .154 -9. .832 1. .00 83. .79 C

ATOM 3962 OD1 ASP C 97 3. .266 33. .470 -10. .306 1. .00 83. .11 0

ATOM 3963 OD2 ASP C 97 4. .695 35. .137 -10. .428 1. .00 84. .59 0

ATOM 3964 N LYS C 103 6. .522 23. .877 -8. .268 1. .00 60. .57 N

ATOM 3965 CA LYS C 103 6. .249 23. .391 -6. .919 1. .00 59. .36 C

ATOM 3966 C LYS C 103 4. .765 23. .065 -6. .706 1. .00 60. .56 C

ATOM 3967 O LYS C 103 3. .887 23. .798 -7. .171 1. .00 58. .11 O

ATOM 3968 CB LYS C 103 6. .709 24. .418 -5. .874 1. .00 55. .96 c

ATOM 3969 N HIS C 104 4. .502 21. .952 -6. .019 1. .00 58. .31 N

ATOM 3970 CA HIS C 104 3. .196 21. .706 -5. .404 1. .00 56. .13 C

ATOM 3971 C HIS C 104 3. .138 22. , 428 -4. .095 1. .00 52. .65 C

ATOM 3972 O HIS C 104 4. .049 22. .304 -3. .272 1. .00 54. .78 O

ATOM 3973 CB HIS C 104 2. .973 20. .222 -5. .153 1. .00 55. .18 C

ATOM 3974 CG HIS C 104 2. .736 19. .423 -6. .399 1. .00 57. .98 c

ATOM 3975 ND1 HIS c 104 1. .540 19. .394 -7. .025 1. .00 57. .28 N

ATOM 3976 CD2 HIS c 104 3. .586 18. .590 -7. .126 1. .00 58. .40 C

ATOM 3977 CE1 HIS c 104 1. .622 18. .592 -8. .102 1. .00 58. .32 C

ATOM 3978 NE2 HIS c 104 2. .875 18. .097 -8. .162 1. .00 58. .90 N

ATOM 3979 N VAL c 105 2. .065 23. .181 -3. .880 1. .00 53. .23 N

ATOM 3980 CA VAL c 105 1. .901 23. .957 -2. .645 1. .00 55. .61 C

ATOM 3981 C VAL c 105 0. .673 23. .516 -1. .830 1. .00 56. .15 C

ATOM 3982 O VAL c 105 -0. .450 23. .522 -2. .337 1. .00 53. .85 O

ATOM 3983 CB VAL c 105 1. .819 25. .472 -2. .935 1. .00 54. .20 C

ATOM 3984 CGI VAL c 105 1. .746 26. .263 -1. .638 1. .00 53. .62 C

ATOM 3985 CG2 VAL c 105 3. .005 25. .928 -3. .782 1. .00 56. .61 C

ATOM 3986 N TRP c 106 0. .909 23. .148 -0. .566 1. .00 56. .15 N

ATOM 3987 CA TRP c 106 -0. .143 22. .685 0 , .359 1 , .00 49 , .76 C

ATOM 3988 C TRP c 106 -1. .005 23. .796 0 , .863 1 , .00 50 , .05 C

ATOM 3989 O TRP c 106 -0. .523 24. .732 1 , .497 1 , .00 48 , .76 O

ATOM 3990 CB TRP c 106 0. .470 21. .903 1 , .521 1 , .00 45, .13 C

ATOM 3991 CG TRP c 106 1. .027 20. .598 1 , .037 1 , .00 42 , .96 c

ATOM 3992 CD1 TRP c 106 2. .369 20. .244 0 , .878 1 , .00 40 , .86 c

ATOM 3993 CD2 TRP c 106 0. .255 19. .432 0 , .565 1 , .00 41 , .06 c

ATOM 3994 NE1 TRP c 106 2. .476 18. .973 0 , .363 1 , .00 41 , .94 N

ATOM 3995 CE2 TRP c 106 1. .244 18. .428 0 , .153 1 , .00 40 , .71 C

ATOM 3996 CE3 TRP c 106 -1. .110 19. .134 0 , .451 1 , .00 41 , .06 C

ATOM 3997 CZ2 TRP c 106 0. .864 17. .186 -0. .337 1. .00 40. .09 C

ATOM 3998 CZ3 TRP c 106 -1. .483 17. .881 -0. .056 1. .00 40. .12 c

ATOM 3999 CH2 TRP c 106 -0. .520 16. , 931 -0. .438 1. .00 42. .37 c

ATOM 4000 N PHE c 107 -2. .299 23. .704 0 , .579 1 , .00 50 , .36 N

ATOM 4001 CA PHE c 107 -3. .240 24. .720 1 , .017 1 , .00 51 , .08 C

ATOM 4002 C PHE c 107 -3. .197 24. .953 2 , .535 1. .00 52. .19 C

ATOM 4003 O PHE c 107 -3. .125 26. .104 2 , .991 1 , .00 50 , .56 O

ATOM 4004 CB PHE c 107 -4. .654 24. .365 0 , .568 1 , .00 50 , .31 c

ATOM 4005 CG PHE c 107 -5. .721 25. .243 1 , .161 1 , .00 50 , .91 c

ATOM 4006 CD1 PHE c 107 -5. .900 26. .551 0 , .710 1 , .00 50 , .42 c

ATOM 4007 CD2 PHE c 107 -6. .558 24. .759 2 , .165 1 , .00 49 , .17 c

ATOM 4008 CE1 PHE c 107 -6. .888 27. .357 1 , .254 1 , .00 50 , .74 c

ATOM 4009 CE2 PHE c 107 -7. .546 25. .562 2 , .711 1 , .00 48 , .97 c

ATOM 4010 CZ PHE c 107 -7. .714 26. .861 2 , .253 1 , .00 50 , .57 c

ATOM 4011 N GLY c 108 -3. .231 23. .864 3, .301 1 , .00 50 , .11 N ATOM 4012 CA GLY C 108 -3..318 23..943 4..760 1..00 55..08 C

ATOM 4013 C GLY C 108 -2. .025 24. .404 5. .399 1. .00 58. .14 C

ATOM 4014 O GLY C 108 -2. .035 25. .169 6. .363 1. .00 58. .66 O

ATOM 4015 N GLU C 109 -0. .914 23. .949 4. .833 1. .00 61. .33 N

ATOM 4016 CA GLU C 109 0. .408 24. .200 5. .391 1. .00 66. .45 C

ATOM 4017 C GLU C 109 0. .990 25. .578 5. .055 1. .00 67. .33 C

ATOM 4018 O GLU C 109 1. .653 26. .182 5. .899 1. .00 67. .25 O

ATOM 4019 CB GLU C 109 1. .381 23. .097 4. .954 1. .00 68. .13 C

ATOM 4020 CG GLU C 109 0. .893 21. .690 5. .264 1. .00 68. .54 c

ATOM 4021 CD GLU C 109 1. .976 20. .639 5. .126 1. .00 73. .57 c

ATOM 4022 OE1 GLU C 109 2. .955 20. .865 4. .380 1. .00 75. .84 0

ATOM 4023 OE2 GLU C 109 1. .847 19. .578 5. .773 1. .00 73. .08 0

ATOM 4024 N SER C 110 0. .726 26. .080 3. .844 1. .00 66. .48 N

ATOM 4025 CA SER C 110 1. .509 27. .200 3. .293 1. .00 61. .88 C

ATOM 4026 C SER C 110 0. .749 28. .460 2. .863 1. .00 63. .21 C

ATOM 4027 O SER C 110 1. .329 29. , 549 2. , 826 1. , 00 65. , 45 0

ATOM 4028 CB SER C 110 2. .361 26. .711 2. .125 1. .00 56. .94 c

ATOM 4029 OG SER C 110 3. .169 25. .623 2. .522 1. .00 53. .78 0

HETATM 4030 N MSE C 111 -0. .531 28. .324 2. .543 1. .00 60. .28 N

HETATM 4031 CA MSE C 111 -1. .271 29. .434 1. .938 1. .00 60. .86 C

HETATM 4032 C MSE C 111 -1. .836 30. .381 2. .972 1. .00 62. .54 C

HETATM 4033 O MSE C 111 -2. .287 29. .951 4. .043 1. .00 60. .76 O

HETATM 4034 CB MSE C 111 -2. .350 28. .902 0. .988 1. .00 60. .53 c

HETATM 4035 CG MSE C 111 -1. .714 28. .043 -0. ,113 1. , 00 61. , 36 c

HETATM 4036 SE MSE C 111 -2. .864 27. .851 -1. ,714 1. , 00 60. , 35 SE

HETATM 4037 CE MSE C 111 -1. .967 26. .314 -2. , 558 1. , 00 55. , 73 C

ATOM 4038 N ASP c 112 -1. .813 31. .678 2. .645 1. .00 59. .93 N

ATOM 4039 CA ASP c 112 -2. .337 32. , 737 3. , 515 1. , 00 59. , 31 C

ATOM 4040 C ASP c 112 -3. .842 32. .570 3. .739 1. .00 60. .04 C

ATOM 4041 O ASP c 112 -4. .646 32. .712 2. .807 1. .00 60. .00 O

ATOM 4042 CB ASP c 112 -2. .015 34. .127 2. .948 1. , 00 56. , 61 C

ATOM 4043 N GLY c 113 -4. .207 32. .256 4. .982 1. .00 59. .67 N

ATOM 4044 CA GLY c 113 -5. .594 31. .963 5. .345 1. .00 57. .32 C

ATOM 4045 C GLY c 113 -5. .981 30. .513 5. .084 1. .00 57. .41 C

ATOM 4046 O GLY c 113 -7. .164 30. .170 5. .118 1. .00 59. .56 O

ATOM 4047 N GLY c 114 -4. .980 29. .672 4. .816 1. .00 55. .28 N

ATOM 4048 CA GLY c 114 -5. .175 28. .244 4. .574 1. .00 52. .85 C

ATOM 4049 C GLY c 114 -5. .436 27. .455 5. .845 1. .00 55. .68 C

ATOM 4050 O GLY c 114 -5. .092 27. .901 6. .947 1. .00 56. .31 O

ATOM 4051 N PHE c 115 -6. .058 26. .285 5. .689 1. .00 53. .68 N

ATOM 4052 CA PHE c 115 -6. .382 25. .395 6. .808 1. .00 49. .22 C

ATOM 4053 C PHE c 115 -6. .422 23. .947 6. .347 1. .00 48. .74 C

ATOM 4054 O PHE c 115 -6. .720 23. , 663 5. , 185 1. , 00 46. , 47 O

ATOM 4055 CB PHE c 115 -7. .720 25. .779 7. .473 1. .00 47. .54 C

ATOM 4056 CG PHE c 115 -8. .886 25. .869 6. .515 1. .00 47. .72 c

ATOM 4057 CD1 PHE c 115 -9. .559 24. .716 6. .088 1. , 00 46. , 83 c

ATOM 4058 CD2 PHE c 115 -9. .330 27. .112 6. .052 1. .00 46. .66 c

ATOM 4059 CE1 PHE c 115 -10. .631 24. .805 5. .204 1. .00 48. .00 c

ATOM 4060 CE2 PHE c 115 -10. .408 27. .208 5. .175 1. .00 47. .62 c

ATOM 4061 CZ PHE c 115 -11. .059 26. .052 4. .748 1. .00 47. .78 c

ATOM 4062 N GLN c 116 -6. .106 23. .030 7. .254 1. .00 48. .26 N

ATOM 4063 CA GLN c 116 -6. .285 21. .610 6. .972 1. .00 48. .60 C

ATOM 4064 C GLN c 116 -7. .742 21. .257 7. .234 1. .00 46. .97 c

ATOM 4065 O GLN c 116 -8. .395 21. .910 8. .049 1. .00 44. .18 0

ATOM 4066 CB GLN c 116 -5. .343 20. .758 7. .813 1. .00 48. .90 c

ATOM 4067 CG GLN c 116 -3. .885 21. .119 7. .610 1. .00 52. .45 c

ATOM 4068 CD GLN c 116 -3. .014 19. .905 7. .397 1. .00 52. .96 c

ATOM 4069 OE1 GLN c 116 -3. .225 18. .859 8. .004 1. .00 55. .23 0

ATOM 4070 NE2 GLN c 116 -2. .023 20. .040 6. .526 1. .00 56. .03 N

ATOM 4071 N PHE c 117 -8. .264 20. .259 6. .521 1. .00 47. .32 N

ATOM 4072 CA PHE c 117 -9. .692 19. .928 6. .621 1. .00 46. .68 C ATOM 4073 C PHE C 117 -9..897 19..066 7..848 1..00 43..90 C

ATOM 4074 O PHE C 117 -9. .057 18. .232 8. .179 1. .00 43. .57 O

ATOM 4075 CB PHE C 117 -10. .211 19. .192 5. .373 1. .00 48. .28 C

ATOM 4076 CG PHE C 117 -9. .656 19. .709 4. .066 1. .00 49. .16 C

ATOM 4077 CD1 PHE C 117 -9. .735 21. .061 3. .734 1. .00 50. .43 C

ATOM 4078 CD2 PHE C 117 -9. .073 18. .830 3. .156 1. .00 48. .66 C

ATOM 4079 CE1 PHE C 117 -9. .225 21. .524 2. .532 1. .00 49. .35 C

ATOM 4080 CE2 PHE C 117 -8. .568 19. .284 1. .954 1. .00 48. .28 C

ATOM 4081 CZ PHE C 117 -8. .643 20. .633 1. .641 1. .00 49. .46 C

ATOM 4082 N SER C 118 -11. .009 19. , 283 8. , 526 1. , 00 44. ,26 N

ATOM 4083 CA SER C 118 -11. .326 18. .524 9. .729 1. .00 46. .40 C

ATOM 4084 C SER C 118 -12. .751 18. .021 9. .641 1. .00 46. .85 C

ATOM 4085 O SER C 118 -13. .573 18. .565 8. .887 1. , 00 44. , 74 O

ATOM 4086 CB SER C 118 -11. .138 19. .376 10. .985 1. .00 46. .70 C

ATOM 4087 OG SER C 118 -11. .936 20. .546 10. .912 1. .00 46. .47 0

ATOM 4088 N TYR C 119 -13. .031 16. .979 10. .418 1. .00 47. .46 N

ATOM 4089 CA TYR C 119 -14. .244 16. .198 10. .254 1. .00 47. .70 C

ATOM 4090 C TYR C 119 -14. .856 15. .927 11. .599 1. .00 50. .46 C

ATOM 4091 O TYR C 119 -14. .151 15. .611 12. .555 1. .00 51. .60 O

ATOM 4092 CB TYR C 119 -13. .913 14. .881 9. .550 1. .00 46. .59 C

ATOM 4093 CG TYR C 119 -13. .305 15. .113 8. .200 1. .00 45. .54 c

ATOM 4094 CD1 TYR C 119 -11. .934 15. .299 8. .056 1. .00 45. .55 c

ATOM 4095 CD2 TYR C 119 -14. .105 15. .207 7. .071 1. .00 44. .69 c

ATOM 4096 CE1 TYR c 119 -11. .378 15. .546 6. .818 1. .00 44. .68 c

ATOM 4097 CE2 TYR c 119 -13. .557 15. .452 5. .828 1. .00 44. .07 c

ATOM 4098 CZ TYR c 119 -12. .198 15. .622 5. .706 1. .00 43. .46 c

ATOM 4099 OH TYR c 119 -11. .661 15. .860 4. .467 1. .00 42. .02 0

ATOM 4100 N GLY c 120 -16. .174 16. .050 11. .664 1. .00 51. .14 N

ATOM 4101 CA GLY c 120 -16. .904 15. .789 12. .890 1. .00 53. .40 C

ATOM 4102 C GLY c 120 -17. .282 17. .080 13. .575 1. .00 55. .18 c

ATOM 4103 O GLY c 120 -16. .696 18. .137 13. .296 1. .00 56. .38 0

ATOM 4104 N ASN c 121 -18. .264 16. .974 14. .472 1. .00 53. .63 N

ATOM 4105 CA ASN c 121 -18. .799 18. .104 15. .234 1. .00 51. .36 C

ATOM 4106 C ASN c 121 -17. .687 18. .946 15. .875 1. .00 52. .20 C

ATOM 4107 O ASN c 121 -16. .885 18. .422 16. .657 1. .00 54. .28 O

ATOM 4108 CB ASN c 121 -19. .780 17. .592 16. .290 1. .00 49. .48 c

ATOM 4109 CG ASN c 121 -20. .837 16. .660 15. .708 1. .00 50. .50 c

ATOM 4110 OD1 ASN c 121 -20. .536 15. ,797 14. , 882 1. , 00 49. , 42 0

ATOM 4111 ND2 ASN c 121 -22. .080 16. .830 16. .141 1. .00 48. .26 N

ATOM 4112 N PRO c 122 -17. .616 20. .245 15. .518 1. .00 52. .16 N

ATOM 4113 CA PRO c 122 -16. .534 21. .155 15. .953 1. .00 49. .68 C

ATOM 4114 C PRO c 122 -16. .508 21. .397 17. .461 1. .00 46. .55 C

ATOM 4115 O PRO c 122 -15. .457 21. .713 18. .016 1. .00 47. .41 O

ATOM 4116 CB PRO c 122 -16. .867 22. .467 15. .227 1. .00 51. .25 C

ATOM 4117 CG PRO c 122 -17. .746 22. .060 14. .090 1. .00 52. .24 C

ATOM 4118 CD PRO c 122 -18. .562 20. .922 14. .612 1. .00 51. .36 C

ATOM 4119 N GLU c 123 -17. .665 21. .257 18. .102 1. .00 43. .60 N

ATOM 4120 CA GLU c 123 -17. .794 21. .417 19. .549 1. .00 44. .61 C

ATOM 4121 C GLU c 123 -17. .371 20. .175 20. .345 1. .00 41. .54 C

ATOM 4122 O GLU c 123 -17. .475 20. ,169 21. , 564 1. , 00 41. , 33 O

ATOM 4123 CB GLU c 123 -19. .229 21. .823 19. .923 1. .00 46. .81 C

ATOM 4124 CG GLU c 123 -20. .280 20. .710 19. .842 1. .00 49. .36 c

ATOM 4125 CD GLU c 123 -20. .632 20. .263 18. .418 1. , 00 52. , 94 c

ATOM 4126 OE1 GLU c 123 -20. .112 20. .831 17. .427 1. .00 51. .65 0

ATOM 4127 OE2 GLU c 123 -21. .445 19. .315 18. .289 1. .00 56. .94 0

ATOM 4128 N LEU c 124 -16. .933 19. .119 19. .661 1. .00 37. .48 N

ATOM 4129 CA LEU c 124 -16. .315 17. .976 20. .340 1. .00 34. .54 C

ATOM 4130 C LEU c 124 -14. .801 18. .127 20. .267 1. .00 30. .64 C

ATOM 4131 O LEU c 124 -14. .281 18. .505 19. .226 1. .00 29. .93 0

ATOM 4132 CB LEU c 124 -16. .751 16. .650 19. .710 1. .00 34. .60 c

ATOM 4133 CG LEU c 124 -18. .170 16. .158 20. .000 1. .00 35. .69 c ATOM 4134 CD1 LEU C 124 -18..612 15..105 18..997 1..00 37..29 C

ATOM 4135 CD2 LEU C 124 -18. .283 15. .613 21. .417 1. .00 36. .87 C

ATOM 4136 N PRO C 125 -14. .087 17. .830 21. .369 1. .00 28. .99 N

ATOM 4137 CA PRO C 125 -12. .634 17. .972 21. .372 1. .00 28. .44 C

ATOM 4138 C PRO C 125 -11. .976 17. .095 20. .310 1. .00 29. .04 C

ATOM 4139 O PRO C 125 -12. .537 16. .062 19. .901 1. .00 28. .81 O

ATOM 4140 CB PRO C 125 -12. .237 17. , 485 22. , 770 1. , 00 28. , 42 C

ATOM 4141 CG PRO C 125 -13. .470 17. .649 23. .603 1. .00 29. .03 C

ATOM 4142 CD PRO C 125 -14. .593 17. .334 22. .660 1. .00 29. .44 c

ATOM 4143 N GLU C 126 -10. .782 17. .491 19. .889 1. , 00 28. , 38 N

ATOM 4144 CA GLU C 126 -10. .074 16. .794 18. .821 1. .00 29. .07 C

ATOM 4145 C GLU C 126 -9. .749 15. .322 19. .168 1. .00 28. .31 C

ATOM 4146 O GLU C 126 -9. .872 14. .448 18. .311 1. .00 26. .79 O

ATOM 4147 CB GLU C 126 -8. .815 17. .576 18. .418 1. .00 30. .20 C

ATOM 4148 CG GLU C 126 -8. .238 17. .211 17. .054 1. .00 31. .52 c

ATOM 4149 N ASP C 127 -9. .353 15. .053 20. .419 1. .00 28. .10 N

ATOM 4150 CA ASP C 127 -8. .991 13. .698 20. .838 1. .00 27. .52 C

ATOM 4151 C ASP C 127 -10. .190 12. .760 20. .770 1. .00 26. .84 C

ATOM 4152 O ASP C 127 -10. .037 11. .575 20. .507 1. .00 26. .89 O

ATOM 4153 CB ASP C 127 -8. .389 13. .682 22. .244 1. .00 28. .61 C

ATOM 4154 CG ASP C 127 -9. .331 14. .213 23. .295 1. .00 31. .04 c

ATOM 4155 OD1 ASP C 127 -9. .656 15. .423 23. .250 1. .00 30. .54 0

ATOM 4156 OD2 ASP C 127 -9. .742 13. .420 24. .178 1. .00 32. .49 0

ATOM 4157 N VAL C 128 -11. .376 13. .310 20. .992 1. .00 25. .25 N

ATOM 4158 CA VAL C 128 -12. .604 12. .553 20. .964 1. .00 26. .35 C

ATOM 4159 C VAL C 128 -13. .031 12. .230 19. .529 1. .00 27. .96 C

ATOM 4160 O VAL c 128 -13. .486 11. .106 19. .263 1. .00 27. .04 O

ATOM 4161 CB VAL c 128 -13. .721 13. .298 21. .703 1. .00 25. .75 c

ATOM 4162 CGI VAL c 128 -15. .084 12. .703 21. .391 1. .00 26. .80 c

ATOM 4163 CG2 VAL c 128 -13. .465 13. .266 23. .194 1. .00 25. .54 c

ATOM 4164 N LEU c 129 -12. .912 13. .210 18. .628 1. .00 27. .16 N

ATOM 4165 CA LEU c 129 -13. .179 12. .992 17. .206 1. .00 28. .16 C

ATOM 4166 C LEU c 129 -12. .203 11. .970 16. .620 1. .00 27. .54 C

ATOM 4167 O LEU c 129 -12. .598 11. .126 15. .814 1. .00 25. .42 O

ATOM 4168 CB LEU c 129 -13. .089 14. ,294 16. , 407 1. , 00 28. , 28 c

ATOM 4169 CG LEU c 129 -14. .144 15. .366 16. .708 1. .00 32. .63 c

ATOM 4170 CD1 LEU c 129 -14. .010 16. .530 15. .724 1. .00 33. .64 c

ATOM 4171 CD2 LEU c 129 -15. .570 14. .815 16. .692 1. , 00 32. ,49 c

ATOM 4172 N ASP c 130 -10. .932 12. .075 17. .015 1. .00 27. .31 N

ATOM 4173 CA ASP c 130 -9. .911 11. .098 16. .648 1. .00 27. .93 C

ATOM 4174 C ASP c 130 -10. .335 9. .674 17. .036 1. .00 25. .98 C

ATOM 4175 O ASP c 130 -10. .158 8. .748 16. .283 1. .00 24. .33 0

ATOM 4176 CB ASP c 130 -8. .599 11. .417 17. .357 1. .00 32. .47 c

ATOM 4177 CG ASP c 130 -7. .826 12. .560 16. .705 1. .00 38. .03 c

ATOM 4178 OD1 ASP c 130 -8. .304 13. .112 15. .686 1. .00 43. .13 0

ATOM 4179 OD2 ASP c 130 -6. .739 12. .910 17. .233 1. .00 39. .71 0

ATOM 4180 N VAL c 131 -10. .872 9. .511 18. .235 1. .00 24. .83 N

ATOM 4181 CA VAL c 131 -11. .307 8. .201 18. .692 1. .00 25. .05 C

ATOM 4182 C VAL c 131 -12. .513 7. .709 17. .886 1. .00 25. .64 C

ATOM 4183 O VAL c 131 -12. .569 6. .533 17. .502 1. .00 24. .56 0

ATOM 4184 CB VAL c 131 -11. .573 8. .217 20. .215 1. .00 24. .77 c

ATOM 4185 CGI VAL c 131 -12. .435 7. .039 20. .659 1. .00 24. .18 c

ATOM 4186 CG2 VAL c 131 -10. .245 8. .236 20. .976 1. .00 22. .08 c

ATOM 4187 N GLN c 132 -13. .461 8. .609 17. .609 1. .00 24. .90 N

ATOM 4188 CA GLN c 132 -14. .679 8. .219 16. .886 1. .00 24. .61 C

ATOM 4189 C GLN c 132 -14. .307 7. .732 15. .499 1. .00 24. .38 C

ATOM 4190 O GLN c 132 -14. .805 6. .695 15. .057 1. .00 23. .45 0

ATOM 4191 CB GLN c 132 -15. .695 9. .363 16. .814 1. .00 23. .49 c

ATOM 4192 CG GLN c 132 -16. .307 9. .725 18. .164 1. .00 23. .98 c

ATOM 4193 CD GLN c 132 -17. .292 8. .693 18. .679 1. .00 24. .19 c

ATOM 4194 OE1 GLN c 132 -17. .110 7. .475 18. .509 1. .00 24. .52 0 ATOM 4195 NE2 GLN C 132 -18..353 9..170 19..306 1 ,.00 23..21 N

ATOM 4196 N LEU C 133 -13. .404 8. ,467 14. , 845 1. .00 23. ,76 N

ATOM 4197 CA LEU C 133 -12. .844 8. .072 13. .550 1 , .00 24. .69 C

ATOM 4198 C LEU C 133 -12. .048 6. .757 13. .569 1 , .00 25. .92 C

ATOM 4199 O LEU C 133 -12. .086 5. .992 12. .594 1 , .00 25. .94 O

ATOM 4200 CB LEU C 133 -11. .942 9. .181 13. .005 1 , .00 26. .02 C

ATOM 4201 CG LEU C 133 -12. .605 10. .427 12. .430 1 , .00 27. .47 C

ATOM 4202 CD1 LEU C 133 -11. .508 11. .393 12. .002 1 , .00 29. .85 C

ATOM 4203 CD2 LEU C 133 -13. .468 10. .042 11. .245 1 , .00 27. .95 C

ATOM 4204 N ALA C 134 -11. .287 6. .518 14. .643 1 , .00 23. .71 N

ATOM 4205 CA ALA C 134 -10. .542 5. .272 14. .761 1 , .00 24. .33 C

ATOM 4206 C ALA C 134 -11. .512 4. .084 14. .779 1 , .00 24. .52 C

ATOM 4207 O ALA C 134 -11. .298 3. .117 14. .068 1 , .00 24. .32 O

ATOM 4208 CB ALA C 134 -9. .626 5. , 282 15. , 996 1. .00 23. , 61 C

ATOM 4209 N PHE C 135 -12. .586 4. .190 15. .564 1 , .00 23. .74 N

ATOM 4210 CA PHE C 135 -13. .616 3. .157 15. .641 1 , .00 25. .50 C

ATOM 4211 C PHE C 135 -14. .379 2. .978 14. .342 1. .00 29. , 88 C

ATOM 4212 O PHE C 135 -14. .755 1. .852 14. .003 1 , .00 30. .82 O

ATOM 4213 CB PHE C 135 -14. .642 3. .477 16. .716 1 , .00 23. .78 C

ATOM 4214 CG PHE C 135 -14. .311 2. .928 18. .068 1 , .00 23. .41 c

ATOM 4215 CD1 PHE C 135 -13. .543 3. .674 18. .970 1 , .00 23. .12 c

ATOM 4216 CD2 PHE C 135 -14. .764 1. .666 18. .453 1 , .00 23. .04 c

ATOM 4217 CE1 PHE C 135 -13. .254 3. .177 20. .240 1 , .00 23. .65 c

ATOM 4218 CE2 PHE C 135 -14. .467 1. .162 19. .720 1 , .00 23. .43 c

ATOM 4219 CZ PHE c 135 -13. .724 1. .918 20. .618 1 , .00 22. .46 c

ATOM 4220 N LEU c 136 -14. .642 4. .073 13. .646 1 , .00 32. .16 N

ATOM 4221 CA LEU c 136 -15. .392 4. .044 12. .410 1 , .00 34. .44 C

ATOM 4222 C LEU c 136 -14. .647 3. .253 11. .375 1 , .00 34. .45 c

ATOM 4223 O LEU c 136 -15. .237 2. , 550 10. , 608 1. .00 37. , 82 0

ATOM 4224 CB LEU c 136 -15. .722 5. .442 11. .899 1 , .00 34. .91 c

ATOM 4225 CG LEU c 136 -17. .168 5. .838 12. .112 1 , .00 36. .33 c

ATOM 4226 CD1 LEU c 136 -17. .388 7. .284 11. .751 1. .00 35. , 37 c

ATOM 4227 CD2 LEU c 136 -18. .079 4. .928 11. .320 1 , .00 37. .60 c

ATOM 4228 N ARG c 137 -13. .322 3. .360 11. .383 1 , .00 32. .70 N

ATOM 4229 CA ARG c 137 -12. .492 2. .540 10. .507 1 , .00 35. .27 C

ATOM 4230 C ARG c 137 -12. .600 1. .045 10. .826 1 , .00 38. .60 C

ATOM 4231 O ARG c 137 -12. .685 0. .216 9. .920 1 , .00 40. .86 0

ATOM 4232 CB ARG c 137 -11. .030 2. .987 10. .583 1 , .00 32. .09 c

ATOM 4233 CG ARG c 137 -10. .840 4. .495 10. .545 1 , .00 31. .27 c

ATOM 4234 CD ARG c 137 -9. .446 4. .863 10. .063 1 , .00 32. .09 c

ATOM 4235 NE ARG c 137 -9. .340 6. .280 9. .728 1 , .00 33. .98 N

ATOM 4236 CZ ARG c 137 -9. .027 7. .233 10. .600 1 , .00 34. .95 C

ATOM 4237 NH1 ARG c 137 -8. .788 6. .923 11. .866 1 , .00 36. .17 N

ATOM 4238 NH2 ARG c 137 -8. .953 8. .497 10. .206 1 , .00 36. .42 N

ATOM 4239 N LEU c 138 -12. .595 0. .706 12. .114 1 , .00 36. .85 N

ATOM 4240 CA LEU c 138 -12. .679 -0. , 692 12. , 543 1. .00 35. , 60 C

ATOM 4241 C LEU c 138 -14. .007 -1. , 327 12. , 142 1. .00 34. , 69 C

ATOM 4242 O LEU c 138 -14. .054 -2. ,467 11. , 679 1. .00 34. ,71 O

ATOM 4243 CB LEU c 138 -12. .482 -0. , 800 14. , 057 1. .00 32. , 94 C

ATOM 4244 CG LEU c 138 -12. .602 -2. , 201 14. , 658 1. .00 33. ,01 C

ATOM 4245 CD1 LEU c 138 -13. .979 -2. , 788 14. , 384 1. .00 31. , 13 C

ATOM 4246 CD2 LEU c 138 -11. .510 -3. ,113 14. ,119 1. .00 31. , 45 C

ATOM 4247 N LEU c 139 -15. .080 -0. , 566 12. , 319 1. .00 36. , 88 N

ATOM 4248 CA LEU c 139 -16. .422 -0. , 953 11. , 870 1. .00 34. , 78 C

ATOM 4249 C LEU c 139 -16. .584 -0. , 928 10. , 348 1. .00 36. , 50 C

ATOM 4250 O LEU c 139 -17. .702 -1. , 084 9. ,865 1. .00 35. , 08 O

ATOM 4251 CB LEU c 139 -17. .453 -0. , 025 12. ,491 1. .00 33. , 78 C

ATOM 4252 CG LEU c 139 -17. .636 -0. , 079 14. ,012 1. .00 34. , 33 c

ATOM 4253 CD1 LEU c 139 -18. .004 1. .299 14. .556 1 , .00 31. .77 c

ATOM 4254 CD2 LEU c 139 -18. .683 -1. , 126 14. , 387 1. .00 31. , 45 c

ATOM 4255 N SER c 140 -15. .486 -0. , 745 9. , 600 1. .00 35. , 10 N ATOM 4256 CA SER C 140 -15..562 -0..593 8..139 1..00 33..50 C

ATOM 4257 C SER C 140 -14. .630 -1. .520 7. .373 1. .00 30. .86 C

ATOM 4258 O SER C 140 -13. .502 -1. .719 7. .779 1. .00 28. .12 O

ATOM 4259 CB SER C 140 -15. .242 0 , .850 7 , .742 1 , .00 32 , .06 C

ATOM 4260 OG SER C 140 -16. .089 1 , .746 8 , .425 1 , .00 34 , .11 O

ATOM 4261 N SER C 141 -15. .118 -2. .042 6. .250 1. .00 32. .22 N

ATOM 4262 CA SER C 141 -14. .320 -2. .825 5. .295 1. .00 35. .62 C

ATOM 4263 C SER C 141 -13. .586 -1. .936 4. .328 1. .00 35. .62 C

ATOM 4264 O SER C 141 -12. .590 -2. .341 3. .737 1. .00 38. .27 O

ATOM 4265 CB SER C 141 -15. .233 -3. .682 4. .437 1. .00 34. .69 C

ATOM 4266 OG SER C 141 -16. .047 -4. .467 5. .254 1. .00 39. .91 0

ATOM 4267 N ARG C 142 -14. .122 -0. .736 4. .125 1. .00 34. .82 N

ATOM 4268 CA ARG C 142 -13. .648 0 , .146 3, .075 1 , .00 35, .09 C

ATOM 4269 C ARG C 142 -14. .130 1 , .565 3, .340 1 , .00 33, .25 C

ATOM 4270 O ARG C 142 -15. .053 1 , .790 4 , .139 1 , .00 30 , .28 O

ATOM 4271 CB ARG C 142 -14. .104 -0. .358 1. .692 1. .00 36. .48 c

ATOM 4272 CG ARG C 142 -15. .573 -0. .137 1. .412 1. .00 39. .65 c

ATOM 4273 CD ARG C 142 -16. .100 -1. .064 0. .324 1. .00 46. .41 c

ATOM 4274 NE ARG C 142 -16. .672 -2. .285 0. .893 1. .00 49. .44 N

ATOM 4275 CZ ARG C 142 -16. .364 -3. .522 0. .511 1. .00 49. .84 C

ATOM 4276 NH1 ARG C 142 -15. .499 -3. .725 -0. .479 1. .00 52. .47 N

ATOM 4277 NH2 ARG C 142 -16. .944 -4. .559 1. .114 1. .00 49. .92 N

ATOM 4278 N ALA C 143 -13. .481 2 , .520 2 , .684 1 , .00 31 , .64 N

ATOM 4279 CA ALA C 143 -13. .861 3. .923 2. .798 1. .00 33. .28 C

ATOM 4280 C ALA c 143 -13. .596 4 , .632 1 , .492 1 , .00 32 , .92 C

ATOM 4281 O ALA c 143 -12. .799 4 , .163 0 , .685 1 , .00 34 , .03 O

ATOM 4282 CB ALA c 143 -13. .103 4 , .602 3, .925 1. .00 33. .08 C

ATOM 4283 N SER c 144 -14. .264 5, .766 1 , .295 1 , .00 33, .46 N

ATOM 4284 CA SER c 144 -14. .072 6, .568 0 , .095 1 , .00 33, .69 C

ATOM 4285 C SER c 144 -14. .318 8 , .043 0 , .359 1 , .00 34 , .50 C

ATOM 4286 O SER c 144 -15. .022 8 , .408 1 , .319 1 , .00 34 , .39 O

ATOM 4287 CB SER c 144 -14. .994 6, .096 -1. .028 1. .00 32. .57 C

ATOM 4288 OG SER c 144 -16. .339 6, .411 -0. .729 1. .00 33. .54 0

ATOM 4289 N GLN c 145 -13. .741 8 , .883 -0. .505 1. .00 32. .54 N

ATOM 4290 CA GLN c 145 -13. .986 10 , .315 -0. .449 1. .00 33. .78 C

ATOM 4291 C GLN c 145 -13. .804 10 , .976 -1. .799 1. .00 33. .58 C

ATOM 4292 O GLN c 145 -12. .849 10 , .681 -2. .542 1. .00 31. .53 O

ATOM 4293 CB GLN c 145 -13. .092 11 , .023 0 , .583 1 , .00 31 , .22 C

ATOM 4294 CG GLN c 145 -13. .612 12. .409 0. .949 1. .00 32. .80 c

ATOM 4295 CD GLN c 145 -12. .762 13, .143 1 , .985 1 , .00 35, .61 c

ATOM 4296 OE1 GLN c 145 -13. .083 14 , .273 2 , .376 1 , .00 35, .95 0

ATOM 4297 NE2 GLN c 145 -11. .676 12 , .515 2 , .424 1 , .00 32 , .50 N

ATOM 4298 N GLN c 146 -14. .718 11 , .899 -2. .078 1. .00 32. .01 N

ATOM 4299 CA GLN c 146 -14. .586 12 , .795 -3. .212 1. .00 34. .96 C

ATOM 4300 C GLN c 146 -14. .124 14 , .180 -2. .777 1. .00 33. .48 C

ATOM 4301 O GLN c 146 -14. .389 14 , .627 -1. .659 1. .00 32. .55 O

ATOM 4302 CB GLN c 146 -15. .914 12 , .896 -3. .976 1. .00 36. .43 C

ATOM 4303 CG GLN c 146 -16. .156 11 , .667 -4. .819 1. .00 41. .74 C

ATOM 4304 CD GLN c 146 -17. .516 11 , .629 -5. .485 1. .00 44. .23 C

ATOM 4305 OE1 GLN c 146 -18. .137 12 , .660 -5. .725 1. .00 42. .80 O

ATOM 4306 NE2 GLN c 146 -17. .979 10. .418 -5. .797 1. .00 43. .84 N

ATOM 4307 N ILE c 147 -13. .449 14 , .867 -3. .689 1. .00 34. .74 N

ATOM 4308 CA ILE c 147 -13. .056 16, .244 -3. .469 1. .00 34. .24 C

ATOM 4309 C ILE c 147 -13. .089 16, .973 -4. .810 1. .00 34. .78 C

ATOM 4310 O ILE c 147 -12. .481 16, .518 -5. .791 1. .00 36. .23 O

ATOM 4311 CB ILE c 147 -11. .685 16, .335 -2. .726 1. .00 35. .25 C

ATOM 4312 CGI ILE c 147 -11. .309 17 , .793 -2. .454 1. .00 37. .14 C

ATOM 4313 CG2 ILE c 147 -10. .588 15, .582 -3. .478 1. .00 34. .73 C

ATOM 4314 CD1 ILE c 147 -10. .322 17 , .974 -1. .316 1. .00 38. .83 C

ATOM 4315 N THR c 148 -13. .823 18 , .085 -4. .845 1. .00 35. .44 N

ATOM 4316 CA THR c 148 -14. .008 18 , .903 -6. .055 1. .00 35. .03 C ATOM 4317 C THR C 148 -13..110 20..152 -6..057 1..00 34..86 C

ATOM 4318 O THR C 148 -13. .215 21. .026 -5. .175 1. .00 33. .37 O

ATOM 4319 CB THR C 148 -15. .486 19. .362 -6. .222 1. .00 35. .06 C

ATOM 4320 OG1 THR C 148 -16. .356 18. .229 -6. .253 1. .00 36. .28 O

ATOM 4321 CG2 THR C 148 -15. .686 20. .169 -7. .510 1. .00 35. .67 C

ATOM 4322 N TYR C 149 -12. .260 20. .236 -7. .075 1. .00 34. .23 N

ATOM 4323 CA TYR C 149 -11. .415 21. .416 -7. .316 1. .00 35. .00 C

ATOM 4324 C TYR C 149 -12. .068 22. .386 -8. .323 1. .00 34. .82 C

ATOM 4325 O TYR C 149 -12. .223 22. .057 -9. .509 1. .00 33. .70 O

ATOM 4326 CB TYR C 149 -10. .051 20. .932 -7. .829 1. .00 35. .37 C

ATOM 4327 CG TYR C 149 -8. .987 21. .985 -7. .991 1. .00 36. .81 c

ATOM 4328 CD1 TYR C 149 -8. .306 22. .501 -6. .877 1. .00 37. .20 c

ATOM 4329 CD2 TYR C 149 -8. .633 22. .443 -9. .261 1. .00 37. .15 c

ATOM 4330 CE1 TYR C 149 -7. .309 23. .449 -7. .028 1. .00 37. .67 c

ATOM 4331 CE2 TYR C 149 -7. .646 23. .397 -9. .429 1. .00 37. .61 c

ATOM 4332 CZ TYR C 149 -6. .981 23. .894 -8. .318 1. .00 39. .88 c

ATOM 4333 OH TYR C 149 -5. .992 24. .838 -8. .493 1. .00 38. .63 0

ATOM 4334 N HIS C 150 -12. .475 23. , 560 -7. .848 1. .00 36. .29 N

ATOM 4335 CA HIS C 150 -12. .995 24. .622 -8. .733 1. .00 38. .23 C

ATOM 4336 C HIS C 150 -11. .841 25. .417 -9. .278 1. .00 38. .27 c

ATOM 4337 O HIS C 150 -11. .041 25. .942 -8. .509 1. .00 39. .28 0

ATOM 4338 CB HIS C 150 -13. .972 25. .541 -8. .000 1. .00 37. .73 c

ATOM 4339 CG HIS c 150 -15. .238 24. .853 -7. .568 1. .00 37. .77 c

ATOM 4340 ND1 HIS c 150 -16. .245 24. .583 -8. .422 1. .00 39. .67 N

ATOM 4341 CD2 HIS c 150 -15. .634 24. .367 -6. .328 1. .00 38. .55 C

ATOM 4342 CE1 HIS c 150 -17. .233 23. .956 -7. .763 1. .00 39. .27 C

ATOM 4343 NE2 HIS c 150 -16. .858 23. .827 -6. .479 1. .00 37. .80 N

ATOM 4344 N CYS c 151 -11. .747 25. .512 -10. .605 1. .00 36. .74 N

ATOM 4345 CA CYS c 151 -10. .552 26. .049 -11. .258 1. .00 38. .31 C

ATOM 4346 C CYS c 151 -10. .843 27. .244 -12. .183 1. .00 42. .14 C

ATOM 4347 O CYS c 151 -11. .844 27. .246 -12. .918 1. .00 42. .98 O

ATOM 4348 CB CYS c 151 -9. .884 24. .940 -12. .077 1. .00 34. .29 C

ATOM 4349 SG CYS c 151 -10. .964 24. .272 -13. .359 1. .00 28. .58 S

ATOM 4350 N LYS c 152 -9. .971 28. .253 -12. .140 1. .00 42. .50 N

ATOM 4351 CA LYS c 152 -9. .921 29. .270 -13. .198 1. .00 43. .85 C

ATOM 4352 C LYS c 152 -8. .471 29. .481 -13. .619 1. .00 43. .60 C

ATOM 4353 O LYS c 152 -7. .647 29. .940 -12. .821 1. .00 42. .28 O

ATOM 4354 CB LYS c 152 -10. .574 30. .590 -12. .772 1. .00 46. .50 C

ATOM 4355 CG LYS c 152 -10. .614 31. .630 -13. .895 1. .00 50. .06 c

ATOM 4356 CD LYS c 152 -11. .401 32. .886 -13. .527 1. .00 50. .20 c

ATOM 4357 CE LYS c 152 -10. .506 33. .984 -12. .969 1. .00 49. .69 c

ATOM 4358 NZ LYS c 152 -11. .279 35. .237 -12. .711 1. .00 50. .81 N

ATOM 4359 N ASN c 153 -8. .179 29. .137 -14. .877 1. .00 43. .42 N

ATOM 4360 CA ASN c 153 -6. .806 29. .116 -15. .427 1. .00 44. .43 C

ATOM 4361 C ASN c 153 -5. .872 28. .273 -14. .569 1. .00 43. .93 C

ATOM 4362 O ASN c 153 -4. .728 28. , 637 -14. .314 1. .00 44. .38 O

ATOM 4363 CB ASN c 153 -6. .240 30. .531 -15. .639 1. .00 42. .12 C

ATOM 4364 CG ASN c 153 -7. .061 31. .343 -16. .611 1. .00 40. .92 C

ATOM 4365 OD1 ASN c 153 -7. .295 32. .528 -16. .391 1. .00 42. .60 O

ATOM 4366 ND2 ASN c 153 -7. .516 30. .707 -17. .687 1. .00 37. .55 N

ATOM 4367 N SER c 154 -6. .386 27. .131 -14. .136 1. .00 45. .94 N

ATOM 4368 CA SER c 154 -5. .658 26. .260 -13. .254 1. .00 46. .20 C

ATOM 4369 C SER c 154 -5. .945 24. .815 -13. .602 1. .00 45. .60 C

ATOM 4370 O SER c 154 -7. .044 24. .291 -13. .341 1. .00 45. .07 O

ATOM 4371 CB SER c 154 -6. .024 26. .553 -11. .796 1. .00 47. .13 C

ATOM 4372 OG SER c 154 -5. .189 25. .817 -10. .930 1. .00 47. .62 O

ATOM 4373 N ILE c 155 -4. .945 24. .192 -14. .217 1. .00 44. .81 N

ATOM 4374 CA ILE c 155 -4. .920 22. .754 -14. .441 1. .00 45. .71 C

ATOM 4375 C ILE c 155 -5. .060 22. .050 -13. .091 1. .00 45. .64 C

ATOM 4376 O ILE c 155 -4. .399 22. .431 -12. .110 1. .00 44. .10 O

ATOM 4377 CB ILE c 155 -3. .604 22. , 308 -15. .147 1. .00 46. .86 C ATOM 4378 CGI ILE C 155 -3..378 23..109 -16..446 1..00 49..01 C

ATOM 4379 CG2 ILE C 155 -3. .573 20. .799 -15. .408 1. .00 43. .29 C

ATOM 4380 CD1 ILE C 155 -4. .459 22. .953 -17. .493 1. .00 48. .58 C

ATOM 4381 N ALA C 156 -5. .946 21. .053 -13. .062 1. .00 43. .65 N

ATOM 4382 CA ALA C 156 -6. .177 20. .198 -11. .902 1. .00 43. .60 C

ATOM 4383 C ALA C 156 -5. .677 18. .777 -12. .163 1. .00 43. .54 C

ATOM 4384 O ALA C 156 -5. .132 18. .122 -11. .277 1. .00 41. .16 O

ATOM 4385 CB ALA C 156 -7. .662 20. .168 -11. .567 1. .00 41. .16 C

ATOM 4386 N TYR C 157 -5. .891 18. .294 -13. .381 1. .00 46. .04 N

ATOM 4387 CA TYR C 157 -5. .539 16. .923 -13. .722 1. .00 50. .38 C

ATOM 4388 C TYR C 157 -4. .840 16. .816 -15. .083 1. .00 53. .19 C

ATOM 4389 O TYR C 157 -3. .620 16. .669 -15. .137 1. .00 51. .89 O

ATOM 4390 CB TYR C 157 -6. .773 16. .010 -13. .641 1. .00 48. .72 C

ATOM 4391 CG TYR C 157 -6. .480 14. .552 -13. .917 1. .00 48. .83 c

ATOM 4392 CD1 TYR C 157 -5. .500 13. ,867 -13. .187 1. .00 48. .69 c

ATOM 4393 CD2 TYR C 157 -7. .181 13. .852 -14. .907 1. .00 46. .49 c

ATOM 4394 CE1 TYR C 157 -5. .225 12. .530 -13. .435 1. .00 48. .91 c

ATOM 4395 CE2 TYR C 157 -6. .913 12. .513 -15. .156 1. .00 48. .60 c

ATOM 4396 CZ TYR C 157 -5. .934 11. .859 -14. .417 1. .00 48. .62 c

ATOM 4397 OH TYR C 157 -5. .655 10. .538 -14. .654 1. .00 46. .88 0

HETATM 4398 N MSE C 158 -5. .613 16. .889 -16. .167 1. .00 58. .45 N

HETATM 4399 CA MSE C 158 -5. .063 16. .799 -17. .520 1. .00 62. .20 C

HETATM 4400 C MSE c 158 -4. .730 18. .184 -17. .998 1. .00 59. .93 c

HETATM 4401 O MSE c 158 -5. .512 19. .109 -17. .804 1. .00 57. .63 0

HETATM 4402 CB MSE c 158 -6. .106 16. .142 -18. .427 1. .00 70. .10 c

HETATM 4403 CG MSE c 158 -5. .631 15. .882 -19. .859 1. .00 82. .13 c

HETATM 4404 SE MSE c 158 -4. .984 14. .025 -20. .063 1. .00 89. .66 SE

HETATM 4405 CE MSE c 158 -6. .708 13. .066 -20. .117 1. .00 89. .66 C

ATOM 4406 N ASP c 159 -3. .557 18. .339 -18. .610 1. .00 60. .09 N

ATOM 4407 CA ASP c 159 -3. .189 19. .582 -19. .294 1. .00 64. .10 C

ATOM 4408 C ASP c 159 -3. .371 19. .412 -20. .803 1. .00 63. .07 C

ATOM 4409 O ASP c 159 -2. .686 18. .594 -21. .418 1. .00 63. .94 O

ATOM 4410 CB ASP c 159 -1. .745 19. .985 -18. .958 1. .00 66. .61 C

ATOM 4411 CG ASP c 159 -1. .297 21. .245 -19. .692 1. .00 69. .02 c

ATOM 4412 OD1 ASP c 159 -1. .296 21. .246 -20. .938 1. .00 70. .83 0

ATOM 4413 OD2 ASP c 159 -0. .928 22. .233 -19. .023 1. .00 71. .78 0

ATOM 4414 N GLN c 160 -4. .291 20. .188 -21. .385 1. .00 63. .54 N

ATOM 4415 CA GLN c 160 -4. .659 20. .070 -22. .807 1. .00 67. .28 C

ATOM 4416 C GLN c 160 -3. .475 20. .271 -23. .755 1. .00 69. .42 C

ATOM 4417 O GLN c 160 -3. .317 19. .519 -24. .723 1. .00 67. .57 O

ATOM 4418 CB GLN c 160 -5. .798 21. .032 -23. .170 1. .00 66. .33 c

ATOM 4419 N ALA c 161 -2. .648 21. .275 -23. .450 1. .00 71. .93 N

ATOM 4420 CA ALA c 161 -1. .465 21. , 636 -24. .246 1. .00 73. .56 C

ATOM 4421 C ALA c 161 -0. .333 20. .587 -24. .258 1. .00 76. .68 C

ATOM 4422 O ALA c 161 0. .507 20. .588 -25. .161 1. .00 79. .14 O

ATOM 4423 CB ALA c 161 -0. .929 22. .997 -23. .808 1. .00 69. .75 c

ATOM 4424 N SER c 162 -0. .308 19. .691 -23. .275 1. .00 75. .35 N

ATOM 4425 CA SER c 162 0. .756 18. .690 -23. .208 1. .00 73. .97 C

ATOM 4426 C SER c 162 0. .261 17. .242 -23. .294 1. .00 70. .43 C

ATOM 4427 O SER c 162 1. .070 16. .322 -23. .429 1. .00 69. .27 O

ATOM 4428 CB SER c 162 1. .599 18. .895 -21. .945 1. .00 77. .95 C

ATOM 4429 OG SER c 162 0. .820 18. .693 -20. .778 1. .00 79. .82 0

ATOM 4430 N GLY c 163 -1. .055 17. .044 -23. .214 1. .00 67. .07 N

ATOM 4431 CA GLY c 163 -1. .655 15. .699 -23. .243 1. .00 64. .90 C

ATOM 4432 C GLY c 163 -1. .344 14. .775 -22. .061 1. .00 65. .87 C

ATOM 4433 O GLY c 163 -1. .792 13. .622 -22. .038 1. .00 62. .69 O

ATOM 4434 N ASN c 164 -0. .690 15. .345 -21. .052 1. .00 62. .68 N

ATOM 4435 CA ASN c 164 -0. .195 14. .642 -19. .880 1. .00 64. .34 C

ATOM 4436 C ASN c 164 -0. .624 15. .193 -18. .523 1. .00 64. .46 C

ATOM 4437 O ASN c 164 -1. .266 16. .227 -18. .395 1. .00 64. .75 O

ATOM 4438 CB ASN c 164 1. .321 14. .534 -19. .895 1. .00 63. .47 C ATOM 4439 CG ASN C 164 1..999 15..837 -19..567 1..00 65..35 C

ATOM 4440 OD1 ASN C 164 1. .637 16. .519 -18. .630 1. .00 66. .19 O

ATOM 4441 ND2 ASN C 164 2. .990 16. .185 -20. .347 1. .00 66. .75 N

ATOM 4442 N VAL C 165 -0. .294 14. .424 -17. .510 1. .00 61. .24 N

ATOM 4443 CA VAL C 165 -0. .776 14. .635 -16. .178 1. .00 57. .89 C

ATOM 4444 C VAL C 165 0. .225 15. .215 -15. .199 1. .00 58. .04 C

ATOM 4445 O VAL C 165 -0. .033 15. .258 -14. .022 1. .00 59. .31 O

ATOM 4446 CB VAL C 165 -1. .270 13. .306 -15. .655 1. .00 57. .90 C

ATOM 4447 CGI VAL C 165 -0. .977 13. .170 -14. .184 1. .00 59. .14 C

ATOM 4448 CG2 VAL C 165 -2. .725 13. , 125 -16. .003 1. .00 55. .06 C

ATOM 4449 N LYS C 166 1. .363 15. .674 -15. .675 1. .00 57. .57 N

ATOM 4450 CA LYS C 166 2. .470 16. .024 -14. .798 1. .00 58. .76 C

ATOM 4451 C LYS C 166 2. .180 17. .164 -13. .860 1. .00 59. .48 C

ATOM 4452 O LYS C 166 2. .864 17. .354 -12. .876 1. .00 62. .30 O

ATOM 4453 CB LYS C 166 3. .721 16. .344 -15. .604 1. .00 61. .22 C

ATOM 4454 N LYS C 167 1. .201 17. .961 -14. .223 1. .00 57. .84 N

ATOM 4455 CA LYS C 167 0. .772 19. .153 -13. .481 1. .00 54. .82 C

ATOM 4456 C LYS C 167 -0. .415 18. .852 -12. .554 1. .00 53. .25 C

ATOM 4457 O LYS C 167 -0. .911 19. .753 -11. .860 1. .00 49. .88 O

ATOM 4458 CB LYS C 167 0. .384 20. .288 -14. .443 1. .00 58. .36 C

ATOM 4459 CG LYS C 167 1. .532 20. .976 -15. .169 1. .00 58. .26 c

ATOM 4460 CD LYS C 167 0. .985 22. , 077 -16. .070 1. .00 60. .76 c

ATOM 4461 CE LYS C 167 2. .072 22. .898 -16. .758 1. .00 61. .15 c

ATOM 4462 NZ LYS C 167 1. .497 24. .110 -17. .419 1. .00 61. .41 N

ATOM 4463 N ALA c 168 -0. .870 17. .595 -12. .556 1. .00 47. .85 N

ATOM 4464 CA ALA c 168 -2. .045 17. .181 -11. .781 1. .00 45. .67 C

ATOM 4465 C ALA c 168 -1. .845 17. .428 -10. .294 1. .00 44. .21 C

ATOM 4466 O ALA c 168 -0. .751 17. .204 -9. .762 1. .00 44. .54 O

ATOM 4467 CB ALA c 168 -2. .373 15. .717 -12. .037 1. .00 43. .92 C

ATOM 4468 N LEU c 169 -2. .898 17. .900 -9. .624 1. .00 43. .18 N

ATOM 4469 CA LEU c 169 -2. .822 18. .171 -8. .183 1. .00 40. .51 C

ATOM 4470 C LEU c 169 -2. .631 16. .898 -7. .337 1. .00 39. .68 C

ATOM 4471 O LEU c 169 -2. .805 15. .775 -7. .832 1. .00 38. .16 O

ATOM 4472 CB LEU c 169 -4. .027 18. .994 -7. .699 1. .00 38. .86 C

ATOM 4473 CG LEU c 169 -5. .454 18. .434 -7. .765 1. .00 38. .35 c

ATOM 4474 CD1 LEU c 169 -5. .698 17. .370 -6. .711 1. .00 38. .73 c

ATOM 4475 CD2 LEU c 169 -6. .464 19. , 559 -7. .608 1. .00 37. .01 c

ATOM 4476 N LYS c 170 -2. .266 17. .100 -6. .071 1. .00 38. .94 N

ATOM 4477 CA LYS c 170 -2. .105 16. .024 -5. .094 1. .00 42. .58 C

ATOM 4478 C LYS c 170 -2. .967 16. .264 -3. .849 1. .00 41. .42 C

ATOM 4479 O LYS c 170 -3. .262 17. .419 -3. .475 1. .00 39. .71 O

ATOM 4480 CB LYS c 170 -0. .641 15. .895 -4. .654 1. .00 43. .91 c

ATOM 4481 CG LYS c 170 0. .346 15. .503 -5. .742 1. .00 46. .68 c

ATOM 4482 CD LYS c 170 1. .740 15. .331 -5. .142 1. .00 49. .94 c

ATOM 4483 CE LYS c 170 2. .241 16. .615 -4. .487 1. .00 51. .61 c

ATOM 4484 NZ LYS c 170 3. .448 16. .415 -3. .632 1. .00 54. .74 N

ATOM 4485 N LEU c 171 -3. .351 15. .186 -3. .195 1. .00 40. .18 N

ATOM 4486 CA LEU c 171 -4. .133 15. .263 -1. .974 1. .00 40. .92 C

ATOM 4487 C LEU c 171 -3. .407 14. .596 -0. .826 1. .00 41. .30 C

ATOM 4488 O LEU c 171 -2. .729 13. .618 -1. .030 1. .00 42. .33 O

ATOM 4489 CB LEU c 171 -5. .465 14. .576 -2. .174 1. .00 39. .26 C

ATOM 4490 CG LEU c 171 -6. .315 14. .994 -3. .357 1. .00 37. .54 C

ATOM 4491 CD1 LEU c 171 -7. .272 13. .868 -3. .669 1. .00 34. .94 C

ATOM 4492 CD2 LEU c 171 -7. .078 16. .225 -2. .931 1. .00 37. .01 c

HETATM 4493 N MSE c 172 -3. .555 15. .131 0 , .376 1 , .00 43, .60 N

HETATM 4494 CA MSE c 172 -2. .975 14. .515 1 , .553 1 , .00 47 , .56 C

HETATM 4495 C MSE c 172 -4. .010 13. .723 2 , .291 1 , .00 48 , .03 C

HETATM 4496 O MSE c 172 -5. .011 14. .255 2 , .790 1 , .00 46 , .31 O

HETATM 4497 CB MSE c 172 -2. .435 15. .557 2 , .514 1 , .00 51 , .03 C

HETATM 4498 CG MSE c 172 -1. .614 14. .985 3, .671 1 , .00 60 , .36 c

HETATM 4499 SE MSE c 172 -0. .272 13. .654 3, .118 1 , .00 78 , .18 SE HETATM 4500 CE MSE C 172 0..433 13..152 4 ,.877 1 ,.00 74 ,.28 C

ATOM 4501 N GLY C 173 -3. .762 12. .432 2 , .396 1 , .00 46 , .40 N

ATOM 4502 CA GLY C 173 -4. .624 11. .528 3, .151 1 , .00 50 , .22 C

ATOM 4503 C GLY C 173 -4. .283 11. , 563 4. .628 1. .00 52. .27 C

ATOM 4504 O GLY C 173 -3. .410 12. .321 5, .059 1 , .00 53, .37 O

ATOM 4505 N SER C 174 -4. .990 10. .757 5, .411 1 , .00 54 , .17 N

ATOM 4506 CA SER C 174 -4. .598 10. .501 6, .795 1. .00 54. .66 C

ATOM 4507 C SER C 174 -3. .402 9. .554 6, .793 1 , .00 56, .45 C

ATOM 4508 O SER C 174 -3. .061 8. .979 5, .746 1 , .00 57 , .20 O

ATOM 4509 CB SER C 174 -5. .769 9. .931 7 , .599 1 , .00 50 , .08 C

ATOM 4510 OG SER C 174 -6. .643 10. .980 7 , .976 1 , .00 47 , .46 0

ATOM 4511 N ASN C 175 -2. .760 9. .410 7 , .952 1 , .00 57 , .30 N

ATOM 4512 CA ASN C 175 -1. .532 8. .622 8 , .063 1 , .00 58 , .88 C

ATOM 4513 C ASN C 175 -0. .480 9. .166 7 , .078 1 , .00 56, .98 C

ATOM 4514 O ASN C 175 0. .210 8. .416 6, .384 1 , .00 56, .37 O

ATOM 4515 CB ASN C 175 -1. .812 7. .116 7 , .856 1 , .00 54 , .45 C

ATOM 4516 N GLY C 177 0. .710 10. .194 4 , .086 1 , .00 46 , .15 N

ATOM 4517 CA GLY C 177 0. .341 9. .434 2 , .883 1 , .00 52 , .12 C

ATOM 4518 C GLY C 177 -0. .370 10. .271 1 , .818 1 , .00 54 , .72 C

ATOM 4519 O GLY C 177 -1. .446 10. .833 2 , .066 1 , .00 58 , .83 O

ATOM 4520 N GLU C 178 0. .220 10. .342 0 , .626 1 , .00 52 , .21 N

ATOM 4521 CA GLU C 178 -0. .281 11. .220 -0. .439 1. .00 50. .28 C

ATOM 4522 C GLU C 178 -1. .057 10. .478 -1. .538 1. .00 47. .42 C

ATOM 4523 O GLU C 178 -0. .679 9. .360 -1. .940 1. .00 41. .38 O

ATOM 4524 CB GLU c 178 0. .875 12. .006 -1. .067 1. .00 52. .08 C

ATOM 4525 CG GLU c 178 1. .333 13. .234 -0. .280 1. .00 53. .18 c

ATOM 4526 CD GLU c 178 2. .496 13. .963 -0. .947 1. .00 51. .58 c

ATOM 4527 OE1 GLU c 178 3. .099 13. .413 -1. .891 1. .00 52. .13 0

ATOM 4528 OE2 GLU c 178 2. .819 15. .091 -0. .526 1. .00 55. .15 0

ATOM 4529 N PHE c 179 -2. .143 11. .102 -2. .010 1. .00 43. .92 N

ATOM 4530 CA PHE c 179 -2. .878 10. .572 -3. .168 1. .00 46. .28 C

ATOM 4531 C PHE c 179 -2. .534 11. , 352 -4. .431 1. .00 45. .81 C

ATOM 4532 O PHE c 179 -2. .626 12. .582 -4. .451 1. .00 46. .68 0

ATOM 4533 CB PHE c 179 -4. .395 10. .546 -2. .936 1. .00 46. .42 c

ATOM 4534 CG PHE c 179 -4. .796 9. .925 -1. .631 1. .00 46. .84 c

ATOM 4535 CD1 PHE c 179 -4. .291 8. .678 -1. .249 1. .00 45. .24 c

ATOM 4536 CD2 PHE c 179 -5. .669 10. .597 -0. .771 1. .00 46. .32 c

ATOM 4537 CE1 PHE c 179 -4. .642 8. .120 -0. .032 1. .00 45. .62 c

ATOM 4538 CE2 PHE c 179 -6. .035 10. .037 0 , .444 1 , .00 46 , .14 c

ATOM 4539 CZ PHE c 179 -5. .516 8. .799 0 , .814 1 , .00 46 , .46 c

ATOM 4540 N LYS c 180 -2. .124 10. .633 -5. .473 1. .00 46. .26 N

ATOM 4541 CA LYS c 180 -1. .578 11. .271 -6. .670 1. .00 45. .79 C

ATOM 4542 C LYS c 180 -2. .222 10. .761 -7. .953 1. .00 44. .10 c

ATOM 4543 O LYS c 180 -2. .999 9. ,810 -7. .932 1. .00 43. .26 0

ATOM 4544 CB LYS c 180 -0. .056 11. .085 -6. .723 1. .00 47. .69 c

ATOM 4545 CG LYS c 180 0. .691 11. .606 -5. .497 1. .00 49. .87 c

ATOM 4546 CD LYS c 180 2. .189 11. .800 -5. .722 1. .00 51. .76 c

ATOM 4547 CE LYS c 180 2. .802 10. .795 -6. .693 1. .00 52. .49 c

ATOM 4548 NZ LYS c 180 2. .784 9. .390 -6. .211 1. .00 54. .87 N

ATOM 4549 N ALA c 181 -1. .887 11. .401 -9. .068 1. .00 44. .03 N

ATOM 4550 CA ALA c 181 -2. .401 11. .003 -10. .380 1. .00 46. .48 C

ATOM 4551 C ALA c 181 -1. .685 9. .760 -10. .898 1. .00 46. .64 C

ATOM 4552 O ALA c 181 -2. .267 8. .955 -11. .627 1. .00 45. .08 O

ATOM 4553 CB ALA c 181 -2. .264 12. .149 -11. .373 1. .00 42. .74 C

ATOM 4554 N GLU c 182 -0. .418 9. .625 -10. .518 1. .00 48. .41 N

ATOM 4555 CA GLU c 182 0. .412 8. .492 -10. .920 1. .00 54. .19 C

ATOM 4556 C GLU c 182 1. .215 7. .990 -9. .718 1. .00 56. .52 C

ATOM 4557 O GLU c 182 0. .936 8. .376 -8. .577 1. .00 55. .22 O

ATOM 4558 CB GLU c 182 1. .344 8. ,893 -12. .068 1. .00 54. .96 C

ATOM 4559 CG GLU c 182 0. .617 9. .217 -13. .368 1. .00 57. .08 c

ATOM 4560 CD GLU c 182 1. .497 9. .900 -14. .402 1. .00 57. .58 c ATOM 4561 OE1 GLU C 182 2..267 10..823 -14..036 1..00 58..55 O

ATOM 4562 OE2 GLU C 182 1. .400 9. .514 -15. .588 1. .00 54. .82 O

ATOM 4563 N GLY C 183 2. .207 7. .139 -9. .979 1. .00 59. .72 N

ATOM 4564 CA GLY C 183 3. .028 6. .539 -8. .923 1. .00 62. .17 C

ATOM 4565 C GLY C 183 2. .435 5. .212 -8. .490 1. .00 60. .76 C

ATOM 4566 O GLY C 183 1. .795 4. .530 -9. .294 1. .00 58. .68 O

ATOM 4567 N ASN C 184 2. .637 4. .848 -7. .222 1. .00 63. .21 N

ATOM 4568 CA ASN C 184 2. .093 3. .594 -6. .684 1. .00 65. .12 C

ATOM 4569 C ASN C 184 0. .578 3. .498 -6. .854 1. .00 63. .65 C

ATOM 4570 O ASN C 184 -0. .154 4. .431 -6. .514 1. .00 63. .40 O

ATOM 4571 CB ASN C 184 2. .473 3. .414 -5. .213 1. .00 67. .51 C

ATOM 4572 CG ASN C 184 2. .202 2. .005 -4. .699 1. .00 71. .84 c

ATOM 4573 OD1 ASN C 184 1. .861 1. .095 -5. .464 1. .00 73. .54 0

ATOM 4574 ND2 ASN C 184 2. .366 1. .817 -3. .394 1. .00 69. .55 N

ATOM 4575 N SER C 185 0. .116 2. .367 -7. .354 1. .00 62. .16 N

ATOM 4576 CA SER C 185 -1. .286 2. .183 -7. .674 1. .00 60. .83 C

ATOM 4577 C SER C 185 -2. .165 2. .266 -6. .453 1. .00 60. .59 C

ATOM 4578 O SER C 185 -3. .264 2. .767 -6. .510 1. .00 62. .75 O

ATOM 4579 CB SER C 185 -1. .523 0. .865 -8. .423 1. .00 59. .73 C

ATOM 4580 OG SER C 185 -1. .208 -0. , 256 -7. .639 1. .00 59. .56 O

ATOM 4581 N LYS C 186 -1. .688 1. .730 -5. .351 1. .00 58. .23 N

ATOM 4582 CA LYS C 186 -2. .457 1. .701 -4. .104 1. .00 55. .65 C

ATOM 4583 C LYS c 186 -2. .824 3. .117 -3. .646 1. .00 53. .29 C

ATOM 4584 O LYS c 186 -3. .745 3. .291 -2. .839 1. .00 46. .44 O

ATOM 4585 CB LYS c 186 -1. .676 0. .974 -2. .992 1. .00 56. .04 C

ATOM 4586 CG LYS c 186 -1. .650 -0. , 548 -3. .117 1. .00 55. .31 c

ATOM 4587 CD LYS c 186 -0. .467 -1. , 134 -2. .351 1. .00 54. .04 c

ATOM 4588 N PHE c 187 -2. .108 4. .116 -4. .174 1. .00 50. .61 N

ATOM 4589 CA PHE c 187 -2. .219 5. .506 -3. .703 1. .00 48. .61 C

ATOM 4590 C PHE c 187 -2. .750 6. .511 -4. .730 1. .00 44. .33 C

ATOM 4591 O PHE c 187 -2. .848 7. .712 -4. .444 1. .00 44. .94 O

ATOM 4592 CB PHE c 187 -0. .881 5. .982 -3. .116 1. .00 49. .53 c

ATOM 4593 CG PHE c 187 -0. .594 5. .426 -1. .743 1. .00 54. .32 c

ATOM 4594 CD1 PHE c 187 -0. .046 4. .151 -1. .588 1. .00 54. .04 c

ATOM 4595 CD2 PHE c 187 -0. .888 6. .169 -0. .600 1. .00 55. .15 c

ATOM 4596 CE1 PHE c 187 0. .213 3. .639 -0. .322 1. .00 54. .69 c

ATOM 4597 CE2 PHE c 187 -0. .631 5. .658 0 , .668 1 , .00 55, .89 c

ATOM 4598 CZ PHE c 187 -0. .080 4. .391 0 , .806 1 , .00 52 , .58 c

ATOM 4599 N THR c 188 -3. .093 6. .025 -5. .915 1. .00 41. .29 N

ATOM 4600 CA THR c 188 -3. .666 6. .884 -6. .958 1. .00 40. .85 C

ATOM 4601 C THR c 188 -5. .153 7. .128 -6. .758 1. .00 38. .02 c

ATOM 4602 O THR c 188 -5. .921 6. .185 -6. .560 1. .00 37. .36 0

ATOM 4603 CB THR c 188 -3. .515 6. .263 -8. .350 1. .00 40. .72 c

ATOM 4604 OG1 THR c 188 -4. .092 4. .948 -8. .335 1. .00 38. .39 0

ATOM 4605 CG2 THR c 188 -2. .041 6. .210 -8. .757 1. .00 40. .88 c

ATOM 4606 N TYR c 189 -5. .551 8. .396 -6. .831 1. .00 37. .58 N

ATOM 4607 CA TYR c 189 -6. .957 8. .759 -6. .905 1. .00 36. .99 C

ATOM 4608 C TYR c 189 -7. .514 8. .450 -8. .297 1. .00 39. .35 C

ATOM 4609 O TYR c 189 -6. .757 8. .130 -9. .209 1. .00 39. .84 0

ATOM 4610 CB TYR c 189 -7. .158 10. .233 -6. .540 1. .00 37. .03 c

ATOM 4611 CG TYR c 189 -6. .315 11. .266 -7. .295 1. .00 36. .27 c

ATOM 4612 CD1 TYR c 189 -6. .400 11. .407 -8. .682 1. .00 36. .30 c

ATOM 4613 CD2 TYR c 189 -5. .483 12. .141 -6. .606 1. .00 37. .22 c

ATOM 4614 CE1 TYR c 189 -5. .656 12. , 365 -9. .358 1. .00 37. .38 c

ATOM 4615 CE2 TYR c 189 -4. .740 13. .108 -7. .272 1. .00 37. .47 c

ATOM 4616 CZ TYR c 189 -4. .828 13. .212 -8. .652 1. .00 38. .42 c

ATOM 4617 OH TYR c 189 -4. .094 14. .174 -9. .322 1. .00 39. .61 0

ATOM 4618 N THR c 190 -8. .838 8. .503 -8. .446 1. .00 41. .67 N

ATOM 4619 CA THR c 190 -9. .475 8. .468 -9. .768 1. .00 41. .08 c

ATOM 4620 C THR c 190 -10. .165 9. .805 -10. .005 1. .00 41. .72 c

ATOM 4621 O THR c 190 -10. .523 10. .504 -9. .054 1. .00 41. .37 0 ATOM 4622 CB THR C 190 -10..517 7..333 -9..928 1..00 39..85 C

ATOM 4623 OG1 THR C 190 -11. .578 7. .516 -8. .986 1. .00 42. .96 O

ATOM 4624 CG2 THR C 190 -9. .889 5. .961 -9. .725 1. .00 39. .52 C

ATOM 4625 N VAL C 191 -10. .350 10. .149 -11. .276 1. .00 40. .93 N

ATOM 4626 CA VAL C 191 -10. .948 11. .413 -11. .666 1. .00 40. .37 C

ATOM 4627 C VAL C 191 -12. .314 11. .165 -12. .309 1. .00 41. .23 C

ATOM 4628 O VAL C 191 -12. .425 10. .324 -13. .191 1. .00 40. .37 O

ATOM 4629 CB VAL C 191 -10. .009 12. , 147 -12. .632 1. .00 40. .54 C

ATOM 4630 CGI VAL C 191 -10. .535 13. .539 -12. .954 1. .00 41. .33 C

ATOM 4631 CG2 VAL C 191 -8. .619 12. .233 -12. .016 1. .00 42. .61 c

ATOM 4632 N LEU C 192 -13. .313 11. .889 -11. .858 1. .00 44. .00 N

ATOM 4633 CA LEU C 192 -14. .652 11. .739 -12. .349 1. .00 45. .06 C

ATOM 4634 C LEU C 192 -15. .059 12. .706 -13. .452 1. .00 44. .96 C

ATOM 4635 O LEU C 192 -15. .596 12. .242 -14. .383 1. .00 47. .29 O

ATOM 4636 CB LEU C 192 -15. .651 11. .744 -11. .219 1. .00 45. .47 c

ATOM 4637 CG LEU C 192 -15. .393 10. .814 -10. .057 1. .00 47. .97 c

ATOM 4638 CD1 LEU C 192 -16. .547 10. .885 -9. .095 1. .00 48. .75 c

ATOM 4639 CD2 LEU c 192 -15. .159 9. .401 -10. .503 1. .00 46. .54 c

ATOM 4640 N GLU c 193 -14. .841 14. .021 -13. .336 1. .00 47. .42 N

ATOM 4641 CA GLU c 193 -14. .911 14. .983 -14. .476 1. .00 44. .62 C

ATOM 4642 C GLU c 193 -13. .651 15. .750 -14. .427 1. .00 42. .39 C

ATOM 4643 O GLU c 193 -13. .101 15. .948 -13. .397 1. .00 43. .76 O

ATOM 4644 CB GLU c 193 -16. .139 15. , 986 -14. .589 1. .00 45. .20 c

ATOM 4645 CG GLU c 193 -16. .616 16. .321 -16. .076 1. .00 40. .58 c

ATOM 4646 CD GLU c 193 -16. .849 17. .829 -16. .500 1. .00 42. .54 c

ATOM 4647 OE1 GLU c 193 -16. .970 18. .804 -15. .651 1. .00 28. .84 0

ATOM 4648 OE2 GLU c 193 -16. .886 18. .030 -17. .706 1. .00 44. .06 0

ATOM 4649 N ASP c 194 -13. .200 16. .157 -15. .580 1. .00 41. .11 N

ATOM 4650 CA ASP c 194 -12. .060 17. .005 -15. .688 1. .00 43. .05 C

ATOM 4651 C ASP c 194 -12. .401 18. .133 -16. .649 1. .00 43. .35 C

ATOM 4652 O ASP c 194 -12. .263 17. .984 -17. .837 1. .00 45. .18 0

ATOM 4653 CB ASP c 194 -10. .883 16. .181 -16. .192 1. .00 40. .42 c

ATOM 4654 CG ASP c 194 -9. .582 16. .868 -16. .012 1. .00 43. .21 c

ATOM 4655 OD1 ASP c 194 -9. .578 17. .976 -15. .482 1. .00 41. .35 0

ATOM 4656 OD2 ASP c 194 -8. .555 16. .297 -16. .398 1. .00 45. .58 0

ATOM 4657 N GLY c 195 -12. .824 19. .266 -16. .122 1. .00 41. .96 N

ATOM 4658 CA GLY c 195 -13. .138 20. .423 -16. .938 1. .00 42. .20 C

ATOM 4659 C GLY c 195 -12. .079 21. .504 -16. .842 1. .00 44. .85 C

ATOM 4660 O GLY c 195 -12. .255 22. .599 -17. .380 1. .00 43. .09 0

ATOM 4661 N CYS c 196 -10. .976 21. .190 -16. .160 1. .00 43. .98 N

ATOM 4662 CA CYS c 196 -9. .914 22. .152 -15. .879 1. .00 41. .08 C

ATOM 4663 C CYS c 196 -8. .740 22. .030 -16. .851 1. .00 46. .09 C

ATOM 4664 O CYS c 196 -7. .677 22. .626 -16. .621 1. .00 47. .03 O

ATOM 4665 CB CYS c 196 -9. .427 21. .969 -14. .432 1. .00 39. .27 c

ATOM 4666 SG CYS c 196 -10. .723 22. .261 -13. .205 1. .00 30. .84 s

ATOM 4667 N THR c 197 -8. .930 21. .276 -17. .937 1. .00 46. .67 N

ATOM 4668 CA THR c 197 -7. .824 20. .968 -18. .869 1. .00 51. .89 C

ATOM 4669 C THR c 197 -7. .168 22. .182 -19. .571 1. .00 54. .52 C

ATOM 4670 O THR c 197 -5. .982 22. .128 -19. .937 1. .00 53. .09 O

ATOM 4671 CB THR c 197 -8. .219 19. .913 -19. .931 1. .00 53. .35 c

ATOM 4672 OG1 THR c 197 -9. .224 20. , 453 -20. .802 1. .00 56. .11 0

ATOM 4673 CG2 THR c 197 -8. .735 18. .638 -19. .275 1. .00 48. .40 c

ATOM 4674 N LYS c 198 -7. .921 23. .269 -19. .744 1. .00 55. .20 N

ATOM 4675 CA LYS c 198 -7. .422 24. .422 -20. .495 1. .00 57. .62 C

ATOM 4676 C LYS c 198 -7. .567 25. .733 -19. .728 1. .00 57. .23 C

ATOM 4677 O LYS c 198 -8. .562 25. .944 -19. .033 1. .00 56. .40 O

ATOM 4678 CB LYS c 198 -8. .147 24. .519 -21. .851 1. .00 62. .40 c

ATOM 4679 CG LYS c 198 -7. .348 25. .175 -22. .979 1. .00 67. .35 c

ATOM 4680 CD LYS c 198 -8. .171 25. .274 -24. .265 1. .00 70. .01 c

ATOM 4681 CE LYS c 198 -7. .380 25. .855 -25. .434 1. .00 66. .15 c

ATOM 4682 NZ LYS c 198 -7. .230 27. .336 -25. .382 1. .00 64. .69 N ATOM 4683 N HIS C 199 -6..564 26..603 -19..851 1..00 55..51 N

ATOM 4684 CA HIS C 199 -6. .710 28. .006 -19. .470 1. .00 54. .83 C

ATOM 4685 C HIS C 199 -7. .739 28. .595 -20. .398 1. .00 52. .68 C

ATOM 4686 O HIS C 199 -7. .441 28. .840 -21. .567 1. .00 51. .29 O

ATOM 4687 CB HIS C 199 -5. .385 28. .766 -19. .628 1. .00 55. .07 C

ATOM 4688 CG HIS C 199 -4. .362 28. .478 -18. .546 1. .00 57. .81 C

ATOM 4689 ND1 HIS C 199 -3. .786 29. .456 -17. .816 1. .00 58. .62 N

ATOM 4690 CD2 HIS C 199 -3. .812 27. .278 -18. .095 1. .00 59. .74 C

ATOM 4691 CE1 HIS C 199 -2. .920 28. .914 -16. .941 1. .00 58. .03 C

ATOM 4692 NE2 HIS C 199 -2. .939 27. .579 -17. .109 1. .00 61. .56 N

ATOM 4693 N THR C 200 -8. .966 28. .794 -19. .915 1. .00 48. .81 N

ATOM 4694 CA THR C 200 -10. .019 29. .402 -20. .758 1. .00 48. .53 C

ATOM 4695 C THR C 200 -10. .458 30. .785 -20. .251 1. .00 46. .78 C

ATOM 4696 O THR C 200 -11. .165 31. .510 -20. .956 1. .00 46. .10 O

ATOM 4697 CB THR C 200 -11. .280 28. .510 -20. .906 1. .00 48. .58 C

ATOM 4698 OG1 THR C 200 -11. .967 28. .433 -19. .650 1. .00 48. .31 O

ATOM 4699 CG2 THR C 200 -10. .940 27. .091 -21. .415 1. .00 48. .09 C

ATOM 4700 N GLY C 201 -10. .051 31. , 123 -19. .035 1. .00 43. .74 N

ATOM 4701 CA GLY C 201 -10. .473 32. .330 -18. .361 1. .00 43. .36 C

ATOM 4702 C GLY C 201 -11. .787 32. .185 -17. .628 1. .00 44. .94 C

ATOM 4703 O GLY c 201 -12. .294 33. .103 -17. .029 1. .00 43. .25 O

ATOM 4704 N GLU c 202 -12. .325 30. .990 -17. .650 1. .00 49. .35 N

ATOM 4705 CA GLU c 202 -13. .627 30. .746 -17. .089 1. .00 51. .23 C

ATOM 4706 C GLU c 202 -13. .558 29. .719 -15. .980 1. .00 48. .57 C

ATOM 4707 O GLU c 202 -12. .595 29. .001 -15. .860 1. .00 47. .02 O

ATOM 4708 CB GLU c 202 -14. .590 30. .335 -18. .189 1. .00 54. .58 C

ATOM 4709 CG GLU c 202 -14. .616 31. .363 -19. .293 1. .00 62. .11 c

ATOM 4710 CD GLU c 202 -15. .892 31. .372 -20. .098 1. .00 66. .55 c

ATOM 4711 OE1 GLU c 202 -16. .306 30. .300 -20. .545 1. .00 68. .42 0

ATOM 4712 OE2 GLU c 202 -16. .454 32. .456 -20. .298 1. .00 70. .70 0

ATOM 4713 N TRP c 203 -14. .567 29. .719 -15. .129 1. .00 45. .61 N

ATOM 4714 CA TRP c 203 -14. .639 28. .775 -14. .021 1. .00 42. .10 C

ATOM 4715 C TRP c 203 -15. .120 27. , 430 -14. .483 1. .00 40. .93 C

ATOM 4716 O TRP c 203 -16. .090 27. .332 -15. .241 1. .00 39. .37 0

ATOM 4717 CB TRP c 203 -15. .573 29. .303 -12. .941 1. .00 41. .94 c

ATOM 4718 CG TRP c 203 -14. .912 30. .340 -12. .076 1. .00 42. .57 c

ATOM 4719 CD1 TRP c 203 -15. .031 31. .728 -12. .162 1. .00 41. .08 c

ATOM 4720 CD2 TRP c 203 -13. .980 30. .104 -10. .969 1. .00 41. .84 c

ATOM 4721 NE1 TRP c 203 -14. .262 32. .342 -11. .211 1. .00 41. .13 N

ATOM 4722 CE2 TRP c 203 -13. .609 31. .431 -10. .457 1. .00 41. .20 C

ATOM 4723 CE3 TRP c 203 -13. .432 28. .970 -10. .372 1. .00 41. .66 C

ATOM 4724 CZ2 TRP c 203 -12. .733 31. .590 -9. .391 1. .00 40. .99 c

ATOM 4725 CZ3 TRP c 203 -12. .546 29. .145 -9. .298 1. .00 41. .27 c

ATOM 4726 CH2 TRP c 203 -12. .209 30. .424 -8. .821 1. .00 41. .84 c

ATOM 4727 N SER c 204 -14. .425 26. , 384 -14. .048 1. .00 38. .88 N

ATOM 4728 CA SER c 204 -14. .884 25. .012 -14. .229 1. .00 38. .83 C

ATOM 4729 C SER c 204 -14. .451 24. .191 -13. .000 1. .00 38. .23 C

ATOM 4730 O SER c 204 -14. .119 24. .759 -11. .964 1. .00 40. .09 O

ATOM 4731 CB SER c 204 -14. .359 24. .430 -15. .545 1. .00 38. .75 c

ATOM 4732 OG SER c 204 -14. .959 23. .173 -15. .811 1. .00 39. .17 0

ATOM 4733 N LYS c 205 -14. .455 22. .867 -13. .106 1. .00 37. .79 N

ATOM 4734 CA LYS c 205 -14. .180 22. .007 -11. .948 1. .00 37. .47 C

ATOM 4735 C LYS c 205 -13. .731 20. .602 -12. .343 1. .00 35. .58 C

ATOM 4736 O LYS c 205 -14. .111 20. .101 -13. .408 1. .00 33. .15 O

ATOM 4737 CB LYS c 205 -15. .409 21. .920 -11. .030 1. .00 35. .11 c

ATOM 4738 CG LYS c 205 -16. .616 21. .303 -11. .706 1. .00 35. .50 c

ATOM 4739 CD LYS c 205 -17. .670 20. .913 -10. .703 1. .00 35. .33 c

ATOM 4740 CE LYS c 205 -18. .744 20. .068 -11. .350 1. .00 37. .38 c

ATOM 4741 NZ LYS c 205 -19. .616 19. .528 -10. .278 1. .00 41. .26 N

ATOM 4742 N THR c 206 -12. .923 19. .988 -11. .471 1. .00 34. .48 N

ATOM 4743 CA THR c 206 -12. .461 18. .603 -11. .628 1. .00 34. .27 C ATOM 4744 C THR C 206 -12..804 17..819 -10..352 1..00 34..86 C

ATOM 4745 O THR C 206 -12. .579 18. .310 -9. .236 1. .00 32. .54 O

ATOM 4746 CB THR C 206 -10. .944 18. .553 -11. .947 1. .00 34. .60 C

ATOM 4747 OG1 THR C 206 -10. .709 19. .174 -13. .218 1. .00 33. .54 O

ATOM 4748 CG2 THR C 206 -10. .409 17. .113 -11. .990 1. .00 31. .54 C

ATOM 4749 N VAL C 207 -13. .382 16. .627 -10. .515 1. .00 34. .13 N

ATOM 4750 CA VAL C 207 -13. .811 15. .834 -9. .364 1. .00 33. .86 C

ATOM 4751 C VAL C 207 -12. .897 14. .630 -9. .152 1. .00 35. .66 C

ATOM 4752 O VAL C 207 -12. .687 13. .822 -10. .068 1. .00 37. .13 O

ATOM 4753 CB VAL C 207 -15. .286 15. .395 -9. .473 1. .00 34. .05 C

ATOM 4754 CGI VAL C 207 -15. .718 14. .644 -8. .220 1. .00 31. .38 c

ATOM 4755 CG2 VAL C 207 -16. .190 16. , 602 -9. .702 1. .00 34. .40 c

ATOM 4756 N PHE C 208 -12. .350 14. .533 -7. .941 1. .00 34. .19 N

ATOM 4757 CA PHE C 208 -11. .431 13. .466 -7. .550 1. .00 33. .87 C

ATOM 4758 C PHE C 208 -12. .081 12. .518 -6. .555 1. .00 34. .62 C

ATOM 4759 O PHE C 208 -12. .951 12. .909 -5. .776 1. .00 32. .47 O

ATOM 4760 CB PHE C 208 -10. .199 14. .060 -6. .875 1. .00 32. .19 c

ATOM 4761 CG PHE C 208 -9. .436 14. .997 -7. .741 1. .00 33. .22 c

ATOM 4762 CD1 PHE C 208 -9. .783 16. .352 -7. .804 1. .00 34. .65 c

ATOM 4763 CD2 PHE C 208 -8. .372 14. .539 -8. .505 1. .00 32. .10 c

ATOM 4764 CE1 PHE C 208 -9. .070 17. .229 -8. .619 1. .00 33. .54 c

ATOM 4765 CE2 PHE C 208 -7. .658 15. .413 -9. .314 1. .00 32. .98 c

ATOM 4766 CZ PHE C 208 -8. .008 16. .754 -9. .369 1. .00 33. .14 c

ATOM 4767 N GLU C 209 -11. .625 11. .274 -6. .562 1. .00 36. .34 N

ATOM 4768 CA GLU c 209 -12. .122 10. .280 -5. .632 1. .00 37. .78 C

ATOM 4769 C GLU c 209 -11. .019 9. .285 -5. .294 1. .00 39. .20 c

ATOM 4770 O GLU c 209 -10. .291 8. .804 -6. .184 1. .00 40. .11 0

ATOM 4771 CB GLU c 209 -13. .333 9. .558 -6. .215 1. .00 39. .56 c

ATOM 4772 CG GLU c 209 -14. .132 8. .762 -5. .200 1. .00 44. .67 c

ATOM 4773 CD GLU c 209 -15. .166 7. .872 -5. .863 1. .00 50. .62 c

ATOM 4774 OE1 GLU c 209 -14. .822 7. .205 -6. .862 1. .00 56. .53 0

ATOM 4775 OE2 GLU c 209 -16. .320 7. .830 -5. .388 1. .00 51. .70 0

ATOM 4776 N TYR c 210 -10. .873 9. .015 -4. .003 1. .00 37. .04 N

ATOM 4777 CA TYR c 210 -9. .990 7. .959 -3. .547 1. .00 36. .23 C

ATOM 4778 C TYR c 210 -10. .813 6. .897 -2. .825 1. .00 36. .15 c

ATOM 4779 O TYR c 210 -11. .641 7. .231 -1. .970 1. .00 38. .79 0

ATOM 4780 CB TYR c 210 -8. .880 8. .511 -2. .644 1. .00 35. .99 c

ATOM 4781 CG TYR c 210 -7. .916 7. .424 -2. .224 1. .00 35. .39 c

ATOM 4782 CD1 TYR c 210 -7. .079 6. .813 -3. .156 1. .00 34. .29 c

ATOM 4783 CD2 TYR c 210 -7. .892 6. , 964 -0. .913 1. .00 35. .60 c

ATOM 4784 CE1 TYR c 210 -6. .215 5. .795 -2. .785 1. .00 35. .82 c

ATOM 4785 CE2 TYR c 210 -7. .037 5. .941 -0. .529 1. .00 34. .64 c

ATOM 4786 CZ TYR c 210 -6. .202 5. .364 -1. .460 1. .00 34. .95 c

ATOM 4787 OH TYR c 210 -5. .356 4. .368 -1. .064 1. .00 33. .05 0

ATOM 4788 N ARG c 211 -10. .615 5. .640 -3. .210 1. .00 35. .96 N

ATOM 4789 CA ARG c 211 -11. .315 4. .494 -2. .623 1. .00 40. .07 c

ATOM 4790 C ARG c 211 -10. .321 3. .447 -2. .135 1. .00 40. .58 c

ATOM 4791 O ARG c 211 -9. .348 3. .157 -2. .821 1. .00 38. .15 0

ATOM 4792 CB ARG c 211 -12. .227 3. .841 -3. .654 1. .00 42. .18 c

ATOM 4793 CG ARG c 211 -13. .623 4. .391 -3. .642 1. .00 44. .60 c

ATOM 4794 CD ARG c 211 -14. .427 4. .017 -4. .873 1. .00 47. .44 c

ATOM 4795 NE ARG c 211 -15. .595 4. .890 -4. .955 1. .00 51. .29 N

ATOM 4796 CZ ARG c 211 -16. .682 4. .777 -4. .191 1. .00 52. .82 C

ATOM 4797 NH1 ARG c 211 -16. .777 3. .806 -3. .288 1. .00 54. .42 N

ATOM 4798 NH2 ARG c 211 -17. .682 5. , 635 -4. .333 1. .00 53. .77 N

ATOM 4799 N THR c 212 -10. .579 2. .859 -0. .967 1. .00 41. .21 N

ATOM 4800 CA THR c 212 -9. .635 1. .892 -0. .393 1. .00 40. .20 C

ATOM 4801 C THR c 212 -10. .263 0. .975 0 , .659 1 , .00 41 , .40 C

ATOM 4802 O THR c 212 -11. .242 1. .341 1 , .322 1 , .00 40 , .30 O

ATOM 4803 CB THR c 212 -8. .399 2. .625 0 , .198 1 , .00 40 , .38 C

ATOM 4804 OG1 THR c 212 -7. .430 1. .678 0 , .666 1 , .00 39, .99 O ATOM 4805 CG2 THR C 212 -8..810 3..579 1..340 1 ,.00 38..85 C

ATOM 4806 N ARG C 213 -9. .694 -0. , 222 0. , 772 1. .00 40. ,81 N

ATOM 4807 CA ARG C 213 -9. .921 -1. , 142 1. , 887 1. .00 45. , 17 C

ATOM 4808 C ARG C 213 -9. .213 -0. , 635 3. ,162 1. .00 46. , 42 C

ATOM 4809 O ARG C 213 -9. .689 -0. , 824 4. , 279 1. .00 49. , 25 O

ATOM 4810 CB ARG C 213 -9. .387 -2. , 518 1. ,495 1. .00 47. , 72 C

ATOM 4811 CG ARG C 213 -9. .820 -3. , 683 2. , 360 1. .00 52. , 72 c

ATOM 4812 CD ARG C 213 -9. .854 -4. , 961 1. , 527 1. .00 52. , 77 c

ATOM 4813 NE ARG C 213 -10. .908 -4. , 905 0. , 516 1. .00 55. , 48 N

ATOM 4814 CZ ARG C 213 -12. .201 -5. , 144 0. , 756 1. .00 57. , 53 C

ATOM 4815 NH1 ARG C 213 -12. .621 -5. ,469 1. , 981 1. .00 52. , 95 N

ATOM 4816 NH2 ARG C 213 -13. .080 -5. , 054 -0. , 234 1. .00 53. , 14 N

ATOM 4817 N LYS C 214 -8. .078 0. .025 2. .989 1 , .00 45. .80 N

ATOM 4818 CA LYS C 214 -7. .329 0. .541 4. .123 1 , .00 44. .43 C

ATOM 4819 C LYS C 214 -7. .850 1. .888 4. .597 1 , .00 42. .75 C

ATOM 4820 O LYS C 214 -7. .314 2. .950 4. .253 1 , .00 44. .37 O

ATOM 4821 CB LYS C 214 -5. .836 0. .558 3. .809 1 , .00 47. .62 C

ATOM 4822 CG LYS C 214 -5. .269 -0. , 847 3. , 593 1. .00 51. ,46 C

ATOM 4823 CD LYS C 214 -5. .222 -1. , 645 4. ,896 1. .00 52. , 75 C

ATOM 4824 CE LYS C 214 -4. .726 -3. ,069 4. , 681 1. .00 51. , 64 C

ATOM 4825 NZ LYS c 214 -5. .718 -3. , 879 3. , 928 1. .00 47. ,89 N

ATOM 4826 N ALA c 215 -8. .898 1. .833 5. .415 1 , .00 38. .95 N

ATOM 4827 CA ALA c 215 -9. .603 3. .035 5. .834 1 , .00 35. .82 C

ATOM 4828 C ALA c 215 -8. .764 3. .980 6. .706 1 , .00 36. .11 C

ATOM 4829 O ALA c 215 -9. .129 5. .147 6. .871 1 , .00 35. .84 O

ATOM 4830 CB ALA c 215 -10. .924 2. .678 6. .506 1 , .00 35. .46 C

ATOM 4831 N VAL c 216 -7. .637 3. .501 7. .238 1 , .00 34. .27 N

ATOM 4832 CA VAL c 216 -6. .686 4. .401 7. .921 1 , .00 35. .65 C

ATOM 4833 C VAL c 216 -6. .149 5. .534 7. .031 1 , .00 36. .70 C

ATOM 4834 O VAL c 216 -5. .723 6. .580 7. .535 1 , .00 34. .93 O

ATOM 4835 CB VAL c 216 -5. .507 3. .649 8. .593 1 , .00 35. .11 C

ATOM 4836 CGI VAL c 216 -6. .035 2. .674 9. .642 1 , .00 35. .75 c

ATOM 4837 CG2 VAL c 216 -4. .643 2. .929 7. .562 1 , .00 32. .90 c

ATOM 4838 N ARG c 217 -6. .178 5. .331 5. .713 1 , .00 37. .34 N

ATOM 4839 CA ARG c 217 -5. .686 6. .347 4. .778 1 , .00 36. .16 C

ATOM 4840 C ARG c 217 -6. .637 7. .520 4. .632 1 , .00 36. .22 C

ATOM 4841 O ARG c 217 -6. .245 8. , 577 4. , 152 1. .00 37. , 77 O

ATOM 4842 CB ARG c 217 -5. .388 5. .740 3. .407 1 , .00 39. .66 c

ATOM 4843 CG ARG c 217 -4. .189 4. .816 3. .409 1 , .00 41. .77 c

ATOM 4844 CD ARG c 217 -4. .057 4. .087 2. .089 1. .00 44. , 84 c

ATOM 4845 NE ARG c 217 -3. .231 2. .900 2. .251 1 , .00 46. .01 N

ATOM 4846 CZ ARG c 217 -3. .179 1. .899 1. .385 1 , .00 46. .33 C

ATOM 4847 NH1 ARG c 217 -3. .897 1. .936 0. .271 1 , .00 46. .54 N

ATOM 4848 NH2 ARG c 217 -2. .408 0. .857 1. .641 1 , .00 45. .75 N

ATOM 4849 N LEU c 218 -7. .883 7. .367 5. .065 1 , .00 34. .73 N

ATOM 4850 CA LEU c 218 -8. .806 8. .499 4. .975 1 , .00 34. .00 C

ATOM 4851 C LEU c 218 -9. .189 9. .033 6. .366 1 , .00 35. .44 C

ATOM 4852 O LEU c 218 -9. .011 8. .332 7. .353 1 , .00 32. .77 O

ATOM 4853 CB LEU c 218 -10. .023 8. .125 4. .126 1 , .00 30. .93 C

ATOM 4854 CG LEU c 218 -9. .708 7. .947 2. .634 1 , .00 30. .71 C

ATOM 4855 CD1 LEU c 218 -10. .832 7. .193 1. .937 1 , .00 30. .08 C

ATOM 4856 CD2 LEU c 218 -9. .435 9. .283 1. .941 1 , .00 30. .87 C

ATOM 4857 N PRO c 219 -9. .712 10. .272 6. .453 1 , .00 36. .22 N

ATOM 4858 CA PRO c 219 -10. .102 11. .185 5. .368 1 , .00 36. .81 C

ATOM 4859 C PRO c 219 -8. .934 11. .961 4. .745 1 , .00 37. .71 C

ATOM 4860 O PRO c 219 -7. .793 11. .852 5. .197 1 , .00 38. .87 O

ATOM 4861 CB PRO c 219 -11. .056 12. .150 6. .071 1 , .00 35. .99 C

ATOM 4862 CG PRO c 219 -10. .529 12. .222 7. .466 1 , .00 38. .18 c

ATOM 4863 CD PRO c 219 -9. .894 10. .891 7. .779 1 , .00 36. .03 c

ATOM 4864 N ILE c 220 -9. .234 12. .725 3. .700 1 , .00 37. .30 N

ATOM 4865 CA ILE c 220 -8. .280 13. .654 3. .101 1 , .00 37. .17 C ATOM 4866 C ILE C 220 -8..165 14.,863 4..025 1..00 37..64 C

ATOM 4867 O ILE C 220 -9. .176 15. .322 4 , .576 1 , .00 37 , .06 O

ATOM 4868 CB ILE C 220 -8. .737 14. .082 1 , .684 1 , .00 35, .24 C

ATOM 4869 CGI ILE C 220 -8. .768 12. .864 0 , .746 1. .00 35. .15 C

ATOM 4870 CG2 ILE C 220 -7. .841 15. .182 1 , .124 1 , .00 33, .45 C

ATOM 4871 CD1 ILE C 220 -9. .624 13. .047 -0. .496 1. .00 35. .51 C

ATOM 4872 N VAL C 221 -6. .944 15. .375 4 , .196 1 , .00 38 , .74 N

ATOM 4873 CA VAL C 221 -6. .694 16. .475 5, .135 1 , .00 37 , .93 C

ATOM 4874 C VAL C 221 -6. .151 17. .747 4 , .487 1 , .00 38 , .63 C

ATOM 4875 O VAL C 221 -6. .289 18. .835 5, .040 1 , .00 35, .81 O

ATOM 4876 CB VAL C 221 -5. .770 16. .031 6, .291 1 , .00 39, .60 C

ATOM 4877 CGI VAL C 221 -6. .449 14. .948 7 , .122 1 , .00 39, .31 C

ATOM 4878 CG2 VAL C 221 -4. .427 15. .540 5, .760 1 , .00 40 , .25 c

ATOM 4879 N ASP C 222 -5. .529 17. .618 3, .321 1 , .00 41 , .02 N

ATOM 4880 CA ASP C 222 -4. .974 18. .788 2 , .628 1 , .00 41 , .25 C

ATOM 4881 C ASP C 222 -5. .029 18. .570 1 , .111 1 , .00 41 , .23 C

ATOM 4882 O ASP c 222 -5. .332 17. .468 0 , .655 1 , .00 41 , .64 O

ATOM 4883 CB ASP c 222 -3. .538 19. .064 3, .115 1 , .00 43, .43 c

ATOM 4884 CG ASP c 222 -3. .162 20. , 559 3. .101 1. .00 46. .07 c

ATOM 4885 OD1 ASP c 222 -3. .973 21. .384 2 , .620 1 , .00 47 , .92 0

ATOM 4886 OD2 ASP c 222 -2. .042 20. .906 3, .574 1 , .00 46 , .29 0

ATOM 4887 N ILE c 223 -4. .749 19. .625 0 , .340 1 , .00 40 , .49 N

ATOM 4888 CA ILE c 223 -4. .776 19. .577 -1. .126 1. .00 39. .90 C

ATOM 4889 C ILE c 223 -3. .613 20. .417 -1. .700 1. .00 40. .71 C

ATOM 4890 O ILE c 223 -3. .344 21. .526 -1. .229 1. .00 41. .57 O

ATOM 4891 CB ILE c 223 -6. .177 20. .002 -1. .667 1. .00 38. .25 c

ATOM 4892 CGI ILE c 223 -6. .279 19. .867 -3. .191 1. .00 39. .37 c

ATOM 4893 CG2 ILE c 223 -6. .553 21. .416 -1. .210 1. .00 37. .70 c

ATOM 4894 CD1 ILE c 223 -7. .711 19. .948 -3. .719 1. .00 37. .36 c

ATOM 4895 N ALA c 224 -2. .913 19. .863 -2. .690 1. .00 42. .24 N

ATOM 4896 CA ALA c 224 -1. .729 20. , 501 -3. .296 1. .00 41. .90 C

ATOM 4897 C ALA c 224 -1. .872 20. .744 -4. .805 1. .00 39. .91 C

ATOM 4898 O ALA c 224 -1. .451 19. .905 -5. .608 1. .00 37. .33 0

ATOM 4899 CB ALA c 224 -0. .481 19. .664 -3. .019 1. .00 42. .94 c

ATOM 4900 N PRO c 225 -2. .450 21. .898 -5. .199 1. .00 42. .74 N

ATOM 4901 CA PRO c 225 -2. .463 22. .223 -6. .631 1. .00 47. .29 C

ATOM 4902 C PRO c 225 -1. .057 22. .576 -7. .136 1. .00 51. .92 C

ATOM 4903 O PRO c 225 -0. .239 23. .100 -6. .368 1. .00 51. .08 O

ATOM 4904 CB PRO c 225 -3. .387 23. .451 -6. .728 1. .00 47. .20 c

ATOM 4905 CG PRO c 225 -3. .804 23. .800 -5. .334 1. .00 46. .56 c

ATOM 4906 CD PRO c 225 -2. .962 23. .007 -4. .373 1. .00 43. .23 c

ATOM 4907 N TYR c 226 -0. .784 22. .275 -8. .407 1. .00 56. .56 N

ATOM 4908 CA TYR c 226 0. .481 22. .662 -9. .049 1. .00 59. .66 C

ATOM 4909 C TYR c 226 0. .377 23. .981 -9. .828 1. .00 59. .77 C

ATOM 4910 O TYR c 226 1. .067 24. .957 -9. .505 1. .00 58. .47 O

ATOM 4911 CB TYR c 226 0. .997 21. .543 -9. .962 1. .00 62. .60 c

ATOM 4912 CG TYR c 226 2. .367 21. .816 -10. .530 1. .00 66. .25 c

ATOM 4913 CD1 TYR c 226 3. .516 21. .536 -9. .787 1. .00 70. .43 c

ATOM 4914 CD2 TYR c 226 2. .518 22. .364 -11. .801 1. .00 68. .01 c

ATOM 4915 CE1 TYR c 226 4. .778 21. .789 -10. .297 1. .00 72. .49 c

ATOM 4916 CE2 TYR c 226 3. .776 22. .620 -12. .322 1. .00 72. .60 c

ATOM 4917 CZ TYR c 226 4. .902 22. .330 -11. .563 1. .00 73. .38 c

ATOM 4918 OH TYR c 226 6. .151 22. .583 -12. .073 1. .00 78. .47 0

ATOM 4919 N ASP c 227 -0. .485 23. .991 -10. .846 1. .00 58. .24 N

ATOM 4920 CA ASP c 227 -0. .654 25. .130 -11. .750 1. .00 56. .82 c

ATOM 4921 C ASP c 227 -1. .306 26. .348 -11. .071 1. .00 58. .16 c

ATOM 4922 O ASP c 227 -2. .503 26. .603 -11. .232 1. .00 57. .94 0

ATOM 4923 CB ASP c 227 -1. .432 24. .699 -13. .007 1. .00 56. .34 c

ATOM 4924 CG ASP c 227 -1. .418 25. .759 -14. .107 1. .00 56. .25 c

ATOM 4925 OD1 ASP c 227 -0. .599 26. .702 -14. .040 1. .00 54. .88 0

ATOM 4926 OD2 ASP c 227 -2. .237 25. .653 -15. .040 1. .00 58. .19 0 ATOM 4927 N ILE C 228 -0..507 27., 071 -10..296 1..00 58..88 N

ATOM 4928 CA ILE C 228 -0. .861 28. .326 -9. .643 1. .00 59. .08 C

ATOM 4929 C ILE C 228 0. .458 29. .053 -9. .367 1. .00 58. .23 C

ATOM 4930 O ILE C 228 1. .484 28. .429 -9. .350 1. .00 60. .11 O

ATOM 4931 CB ILE C 228 -1. .562 28. .087 -8. .295 1. .00 61. .62 C

ATOM 4932 CGI ILE C 228 -0. .737 27. .148 -7. .422 1. .00 61. .96 C

ATOM 4933 CG2 ILE C 228 -2. .970 27. .533 -8. .485 1. .00 61. .61 C

ATOM 4934 CD1 ILE C 228 -1. .188 27. .056 -5. .981 1. .00 57. .91 C

ATOM 4935 N GLY C 229 0. .445 30. .330 -9. .043 1. .00 58. .20 N

ATOM 4936 CA GLY C 229 -0. .671 31. .192 -9. .268 1. .00 59. .37 C

ATOM 4937 C GLY C 229 -0. .159 32. .414 -9. .985 1. .00 61. .18 C

ATOM 4938 O GLY C 229 0. .584 33. .203 -9. .438 1. .00 62. .26 O

ATOM 4939 N GLY C 230 -0. .631 32. .591 -11. .201 1. .00 59. .57 N

ATOM 4940 CA GLY C 230 -0. .489 33. .821 -11. .928 1. .00 61. .06 C

ATOM 4941 C GLY C 230 -1. .538 34. .735 -11. .345 1. .00 63. .03 C

ATOM 4942 O GLY C 230 -2. .333 34. .312 -10. .542 1. .00 62. .17 O

ATOM 4943 N PRO C 231 -1. .525 35. .991 -11. .732 1. .00 62. .80 N

ATOM 4944 CA PRO C 231 -2. .512 36. .937 -11. .238 1. .00 64. .66 C

ATOM 4945 C PRO C 231 -3. .903 36. .453 -11. .618 1. .00 63. .28 C

ATOM 4946 O PRO C 231 -4. .854 36. .691 -10. .904 1. .00 62. .61 O

ATOM 4947 CB PRO C 231 -2. .168 38. .220 -11. .991 1. .00 66. .86 C

ATOM 4948 CG PRO C 231 -1. .425 37. .767 -13. .201 1. .00 66. .08 c

ATOM 4949 CD PRO C 231 -0. .653 36. .579 -12. .752 1. .00 63. .50 c

ATOM 4950 N ASP c 232 -3. .994 35. .851 -12. .790 1. .00 60. .58 N

ATOM 4951 CA ASP c 232 -5. .178 35. .202 -13. .324 1. .00 59. .20 C

ATOM 4952 C ASP c 232 -5. .647 33. , 922 -12. .610 1. .00 56. .66 C

ATOM 4953 O ASP c 232 -6. .811 33. .571 -12. .663 1. .00 54. .32 O

ATOM 4954 CB ASP c 232 -4. .909 34. .881 -14. .777 1. .00 58. .09 c

ATOM 4955 CG ASP c 232 -3. .565 34. .243 -14. .967 1. .00 61. .55 c

ATOM 4956 OD1 ASP c 232 -2. .636 34. .619 -14. .241 1. .00 56. .95 0

ATOM 4957 OD2 ASP c 232 -3. .443 33. .363 -15. .832 1. .00 64. .54 0

ATOM 4958 N GLN c 233 -4. .709 33. .174 -12. .048 1. .00 55. .07 N

ATOM 4959 CA GLN c 233 -4. .990 31. .847 -11. .512 1. .00 51. .64 C

ATOM 4960 C GLN c 233 -5. .731 31. .860 -10. .179 1. .00 49. .38 C

ATOM 4961 O GLN c 233 -5. .324 32. .509 -9. .246 1. .00 48. .65 0

ATOM 4962 CB GLN c 233 -3. .695 31. .056 -11. .408 1. .00 48. .27 c

ATOM 4963 CG GLN c 233 -3. .008 30. .914 -12. .744 1. .00 49. .69 c

ATOM 4964 CD GLN c 233 -1. .816 29. .995 -12. .716 1. .00 47. .23 c

ATOM 4965 OE1 GLN c 233 -0. .836 30. .281 -12. .069 1. .00 48. .64 0

ATOM 4966 NE2 GLN c 233 -1. .890 28. .910 -13. .445 1. .00 43. .77 N

ATOM 4967 N GLU c 234 -6. .829 31. .120 -10. .117 1. .00 47. .36 N

ATOM 4968 CA GLU c 234 -7. .671 31. .050 -8. .914 1. .00 45. .39 C

ATOM 4969 C GLU c 234 -8. .242 29. .642 -8. .755 1. .00 45. .03 C

ATOM 4970 O GLU c 234 -8. .271 28. .861 -9. .719 1. .00 44. .71 O

ATOM 4971 CB GLU c 234 -8. .836 32. .042 -8. .983 1. .00 44. .74 C

ATOM 4972 CG GLU c 234 -8. .470 33. .515 -8. .929 1. .00 48. .89 C

ATOM 4973 CD GLU c 234 -9. .692 34. .418 -8. .990 1. .00 52. .89 C

ATOM 4974 OE1 GLU c 234 -10. .824 33. .937 -8. .761 1. .00 54. .07 0

ATOM 4975 OE2 GLU c 234 -9. .526 35. .621 -9. .268 1. .00 53. .22 0

ATOM 4976 N PHE c 235 -8. .687 29. .335 -7. .534 1. .00 42. .74 N

ATOM 4977 CA PHE c 235 -9. .394 28. .092 -7. .237 1. .00 42. .60 C

ATOM 4978 C PHE c 235 -10. .220 28. .127 -5. .943 1. .00 42. .23 C

ATOM 4979 O PHE c 235 -10. .070 29. , 020 -5. .092 1. .00 40. .64 O

ATOM 4980 CB PHE c 235 -8. .424 26. .885 -7. .223 1. .00 44. .64 c

ATOM 4981 CG PHE c 235 -7. .539 26. .823 -6. .012 1. .00 44. .56 c

ATOM 4982 CD1 PHE c 235 -6. .299 27. .466 -6. .003 1. .00 44. .97 c

ATOM 4983 CD2 PHE c 235 -7. .947 26. .131 -4. .869 1. .00 45. .36 c

ATOM 4984 CE1 PHE c 235 -5. .483 27. .422 -4. .881 1. .00 44. .65 c

ATOM 4985 CE2 PHE c 235 -7. .133 26. .086 -3. .746 1. .00 47. .17 c

ATOM 4986 CZ PHE c 235 -5. .897 26. .732 -3. .753 1. .00 45. .25 c

ATOM 4987 N GLY c 236 -11. .093 27. .131 -5. .825 1. .00 41. .40 N ATOM 4988 CA GLY C 236 -11..817 26..821 -4..601 1..00 38., 48 C

ATOM 4989 C GLY C 236 -11. .928 25. .306 -4. .511 1. .00 39. ,49 C

ATOM 4990 O GLY C 236 -11. .534 24. .598 -5. .444 1. .00 37. , 28 O

ATOM 4991 N VAL C 237 -12. .453 24. .811 -3. .388 1. .00 38. ,41 N

ATOM 4992 CA VAL C 237 -12. .581 23. .375 -3. .145 1. .00 37. , 63 C

ATOM 4993 C VAL C 237 -13. .894 23. .066 -2. .436 1. .00 39. ,29 C

ATOM 4994 O VAL C 237 -14. .307 23. .805 -1. .536 1. .00 37. , 42 O

ATOM 4995 CB VAL C 237 -11. .435 22. .827 -2. .265 1. .00 37. , 98 C

ATOM 4996 CGI VAL C 237 -11. .453 21. .314 -2. .274 1. .00 37. , 66 c

ATOM 4997 CG2 VAL C 237 -10. .070 23. .331 -2. .731 1. .00 38. ,46 c

ATOM 4998 N ASP C 238 -14. .558 21. .997 -2. .867 1. .00 39. ,09 N

ATOM 4999 CA ASP C 238 -15. .638 21. .389 -2. .093 1. .00 40. , 00 C

ATOM 5000 C ASP C 238 -15. .137 20. .035 -1. .595 1. .00 38. , 84 C

ATOM 5001 O ASP C 238 -14. .911 19. .113 -2. .389 1. .00 38. , 07 O

ATOM 5002 CB ASP C 238 -16. .913 21. .183 -2. .926 1. .00 43. , 10 c

ATOM 5003 CG ASP C 238 -17. .504 22. .481 -3. .448 1. .00 45. ,79 c

ATOM 5004 OD1 ASP C 238 -17. .583 23. .472 -2. .694 1. .00 48. , 04 0

ATOM 5005 OD2 ASP C 238 -17. .927 22. .492 -4. .621 1. .00 47. , 70 0

ATOM 5006 N VAL C 239 -14. .935 19. .930 -0. .284 1. .00 38. , 62 N

ATOM 5007 CA VAL C 239 -14. .523 18. .665 0 , .314 1 , .00 38. .00 C

ATOM 5008 C VAL C 239 -15. .793 17. .884 0 , .620 1 , .00 36. .67 C

ATOM 5009 O VAL C 239 -16. .618 18. .316 1 , .422 1 , .00 37. .19 0

ATOM 5010 CB VAL C 239 -13. .672 18. , 845 1. .587 1. .00 39. ,16 c

ATOM 5011 CGI VAL c 239 -12. .984 17. .539 1 , .933 1 , .00 40. .04 c

ATOM 5012 CG2 VAL c 239 -12. .636 19. .955 1 , .412 1 , .00 39. .77 c

ATOM 5013 N GLY c 240 -15. .955 16. .759 -0. .069 1. .00 35. , 38 N

ATOM 5014 CA GLY c 240 -17. .093 15. .881 0 , .129 1 , .00 33. .42 C

ATOM 5015 C GLY c 240 -16. .894 15. .027 1 , .364 1 , .00 33. .87 C

ATOM 5016 O GLY c 240 -15. .759 14. .852 1 , .829 1 , .00 33. .13 0

ATOM 5017 N PRO c 241 -17. .997 14. .486 1 , .909 1 , .00 33. .19 N

ATOM 5018 CA PRO c 241 -17. .874 13. .747 3, .157 1 , .00 32. .23 C

ATOM 5019 C PRO c 241 -16. .951 12. .524 3, .006 1 , .00 31. .99 C

ATOM 5020 O PRO c 241 -16. .842 11. .960 1 , .910 1 , .00 29. .71 O

ATOM 5021 CB PRO c 241 -19. .326 13. .320 3, .459 1 , .00 33. .90 C

ATOM 5022 CG PRO c 241 -20. .035 13. .341 2 , .129 1 , .00 33. .69 c

ATOM 5023 CD PRO c 241 -19. .367 14. .436 1 , .345 1 , .00 34. .34 c

ATOM 5024 N VAL c 242 -16. .265 12. .147 4 , .084 1 , .00 30. .82 N

ATOM 5025 CA VAL c 242 -15. .563 10. .870 4 , .095 1 , .00 29. .73 C

ATOM 5026 C VAL c 242 -16. .600 9. .815 4 , .473 1 , .00 29. .50 C

ATOM 5027 O VAL c 242 -17. .419 10. .023 5, .398 1 , .00 28. .61 O

ATOM 5028 CB VAL c 242 -14. .294 10. .886 4 , .979 1 , .00 30. .55 c

ATOM 5029 CGI VAL c 242 -14. .615 11. .291 6, .412 1 , .00 29. .11 c

ATOM 5030 CG2 VAL c 242 -13. .543 9. .559 4 , .900 1 , .00 29. .32 c

ATOM 5031 N CYS c 243 -16. .616 8. .733 3, .696 1 , .00 29. .19 N

ATOM 5032 CA CYS c 243 -17. .673 7. .733 3, .787 1 , .00 29. .27 C

ATOM 5033 C CYS c 243 -17. .099 6. .346 4 , .067 1 , .00 29. .25 C

ATOM 5034 O CYS c 243 -16. .221 5. .875 3, .343 1 , .00 28. .81 O

ATOM 5035 CB CYS c 243 -18. .532 7. , 731 2. .503 1. .00 30. , 07 c

ATOM 5036 SG CYS c 243 -19. .570 9. .198 2 , .245 1 , .00 27. .27 s

ATOM 5037 N PHE c 244 -17. .609 5. .708 5, .120 1 , .00 28. .25 N

ATOM 5038 CA PHE c 244 -17. .151 4. .391 5, .580 1. .00 29. , 12 C

ATOM 5039 C PHE c 244 -18. .255 3. .349 5, .438 1 , .00 30. .04 C

ATOM 5040 O PHE c 244 -19. .403 3. .614 5, .802 1 , .00 29. .88 O

ATOM 5041 CB PHE c 244 -16. .763 4. .435 7 , .067 1 , .00 28. .78 c

ATOM 5042 CG PHE c 244 -15. .624 5. .368 7 , .388 1 , .00 28. .38 c

ATOM 5043 CD1 PHE c 244 -14. .309 4. .919 7 , .360 1 , .00 29. .32 c

ATOM 5044 CD2 PHE c 244 -15. .868 6. .682 7 , .752 1 , .00 28. .29 c

ATOM 5045 CE1 PHE c 244 -13. .259 5. .776 7 , .664 1 , .00 29. .50 c

ATOM 5046 CE2 PHE c 244 -14. .823 7. .546 8 , .056 1 , .00 28. .24 c

ATOM 5047 CZ PHE c 244 -13. .519 7. .094 8 , .014 1 , .00 28. .75 c

ATOM 5048 N LEU c 245 -17. .896 2. .170 4 , .929 1 , .00 31. .11 N ATOM 5049 CA LEU C 245 -18..788 1..015 4..912 1 ,.00 35..36 C

ATOM 5050 C LEU C 245 -18. .059 -0. , 233 5. , 380 1. .00 36. ,76 C

ATOM 5051 O LEU C 245 -18. .533 -0. , 977 6. , 245 1. .00 39. , 54 O

ATOM 5052 CB LEU C 245 -19. .370 0. .789 3. .509 1 , .00 38. .60 C

ATOM 5053 CG LEU C 245 -20. .166 -0. ,493 3. ,210 1. .00 38. , 69 C

ATOM 5054 CD1 LEU C 245 -21. .390 -0. , 647 4. , 106 1. .00 37. , 36 C

ATOM 5055 CD2 LEU C 245 -20. .565 -0. ,495 1. , 737 1. .00 39. , 20 C

ATOM 5056 OXT LEU C 245 -16. .968 -0. , 531 4. , 911 1. .00 38. , 58 O

TER 5057 LEU C 245

HETATM 5058 CA CA A 246 -15. .447 -6. ,463 29. , 322 1. .00 21. , 39 CA

HETATM 5059 CI GOL A1246 -1. .137 11. .108 34. .337 1 , .00 29. .39 C

HETATM 5060 01 GOL A1246 -2. .052 11. .683 35. .281 1 , .00 27. .54 O

HETATM 5061 C2 GOL A1246 -0. .314 12. .213 33. .677 1 , .00 33. .26 C

HETATM 5062 02 GOL A1246 -1. .174 13. , 175 33. , 051 1. .00 30. , 74 O

HETATM 5063 C3 GOL A1246 0. .584 11. .604 32. .609 1 , .00 35. .37 C

HETATM 5064 03 GOL A1246 1. .645 10. .917 33. .276 1 , .00 41. .30 0

HETATM 5065 CI GOL A1247 -8. .017 17. .183 38. .903 1. .00 42. , 58 c

HETATM 5066 01 GOL A1247 -6. .913 16. .758 39. .721 1 , .00 42. .31 0

HETATM 5067 C2 GOL A1247 -9. .347 16. .953 39. .632 1 , .00 39. .39 c

HETATM 5068 02 GOL A1247 -9. .285 15. .758 40. .396 1 , .00 37. .26 0

HETATM 5069 C3 GOL A1247 -10. .493 16. .805 38. .644 1 , .00 38. .83 c

HETATM 5070 03 GOL A1247 -11. .455 17. .833 38. .918 1 , .00 41. .25 0

HETATM 5071 CI GOL A1248 9. .344 16. .771 36. .668 1 , .00 33. .84 c

HETATM 5072 01 GOL A1248 9. .321 17. .332 37. .979 1 , .00 34. .75 0

HETATM 5073 C2 GOL A1248 10. .780 16. .871 36. .153 1 , .00 35. .22 c

HETATM 5074 02 GOL A1248 11. .073 18. .182 35. .659 1 , .00 36. .06 0

HETATM 5075 C3 GOL A1248 10. .869 15. .904 34. .993 1 , .00 34. .22 c

HETATM 5076 03 GOL A1248 11. .026 14. .598 35. .533 1 , .00 33. .81 0

HETATM 5077 CI GOL A1249 9. .265 15. .513 42. .316 1 , .00 46. .68 c

HETATM 5078 01 GOL A1249 7. .859 15. .573 42. .018 1 , .00 41. .55 0

HETATM 5079 C2 GOL A1249 10. .046 15. .058 41. .088 1 , .00 49. .72 c

HETATM 5080 02 GOL A1249 9. .711 15. .894 39. .964 1 , .00 46. .41 0

HETATM 5081 C3 GOL A1249 11. .541 15. .139 41. .384 1 , .00 50. .44 c

HETATM 5082 03 GOL A1249 12. .254 15. .067 40. .138 1 , .00 48. .95 0

HETATM 5083 CI GOL A1250 10. .937 19. .332 31. .877 1 , .00 32. .87 c

HETATM 5084 01 GOL A1250 11. .926 18. .712 31. .063 1 , .00 30. .14 0

HETATM 5085 C2 GOL A1250 9. .648 18. .531 31. .810 1 , .00 36. .97 c

HETATM 5086 02 GOL A1250 8. .863 18. .980 30. .689 1 , .00 39. .66 0

HETATM 5087 C3 GOL A1250 8. .900 18. .743 33. .119 1 , .00 37. .42 c

HETATM 5088 03 GOL A1250 7. .714 19. .492 32. .841 1 , .00 37. .96 0

HETATM 5089 CA CA B 246 -23. .721 -6. ,197 16. , 008 1. .00 19. , 48 CA

HETATM 5090 CI GOL B1246 -16. .628 -13. , 303 4. , 454 1. .00 46. , 75 c

HETATM 5091 01 GOL B1246 -17. .028 -12. ,860 3. , 158 1. .00 49. , 15 0

HETATM 5092 C2 GOL B1246 -15. .161 -12. , 943 4. , 594 1. .00 46. , 48 c

HETATM 5093 02 GOL B1246 -14. .408 -14. , 145 4. , 749 1. .00 43. , 72 0

HETATM 5094 C3 GOL B1246 -14. .974 -12. , 057 5. ,811 1. .00 44. , 95 c

HETATM 5095 03 GOL B1246 -13. .580 -11. , 754 5. , 919 1. .00 43. , 25 0

HETATM 5096 CI GOL B1247 11. .043 -20. , 582 1. , 056 1. .00 47. , 13 c

HETATM 5097 01 GOL B1247 11. .591 -19. , 676 2. , 025 1. .00 41. , 77 0

HETATM 5098 C2 GOL B1247 9. .721 -21. , 222 1. , 513 1. .00 43. , 36 c

HETATM 5099 02 GOL B1247 9. .976 -22. , 153 2. , 550 1. .00 43. ,29 0

HETATM 5100 C3 GOL B1247 9. .071 -22. ,018 0. , 382 1. .00 45. , 51 c

HETATM 5101 03 GOL B1247 8. .006 -21. , 316 -0. , 270 1. .00 44. , 72 0

HETATM 5102 CA CA C 246 -19. .633 7. .220 22. .869 1 , .00 23. .13 CA

HETATM 5103 O HOH A2001 -18. .973 -1. , 631 42. , 771 1. .00 30. , 66 0

HETATM 5104 O HOH A2002 -14. .555 -6. , 843 38. , 433 1. .00 31. , 04 0

HETATM 5105 O HOH A2003 -20. .749 -0. , 845 33. , 682 1. .00 30. , 00 0

HETATM 5106 O HOH A2004 -18. .944 0. .129 30. .391 1 , .00 28. .44 0

HETATM 5107 0 HOH A2005 -18. .406 4. .537 29. .332 1 , .00 34. .61 0

HETATM 5108 0 HOH A2006 -13. .135 1. .015 23. .983 1 , .00 28. .68 0

HETATM 5109 0 HOH A2007 -10. .694 4. .607 23. .044 1 , .00 27. .78 0 HETATM 5110 0 HOH A2008 -11..488 7..711 24..161 1 ,.00 37..06 O

HETATM 5111 0 HOH A2009 -12. .972 9. .347 23. .474 1 , .00 35. .97 O

HETATM 5112 0 HOH A2010 -8. .991 7. .711 28. .491 1 , .00 22. .40 O

HETATM 5113 0 HOH A2011 -10. .395 16. .448 25. .558 1 , .00 30. .59 O

HETATM 5114 0 HOH A2012 -17. .814 7. .620 24. .492 1 , .00 25. .26 O

HETATM 5115 0 HOH A2013 -15. .109 9. .972 25. .110 1 , .00 30. .07 O

HETATM 5116 0 HOH A2014 -4. .755 5. .013 41. .390 1 , .00 28. .04 O

HETATM 5117 0 HOH A2015 -20. .363 -1. , 732 23. ,167 1. .00 25. ,89 O

HETATM 5118 0 HOH A2016 -23. .544 1. , 045 26. , 155 1. .00 42. , 64 O

HETATM 5119 0 HOH A2017 -7. .334 10. .025 43. .850 1 , .00 24. .30 O

HETATM 5120 0 HOH A2018 -5. .710 15. .372 37. .560 1 , .00 21. .85 O

HETATM 5121 0 HOH A2019 -8. .325 7. .548 44. .257 1. .00 22. , 15 O

HETATM 5122 0 HOH A2020 -12. .039 7. .127 43. .345 1 , .00 25. .74 O

HETATM 5123 0 HOH A2021 -4. .848 2. .116 40. .398 1 , .00 41. .21 O

HETATM 5124 0 HOH A2022 -1. .116 6. .102 38. .530 1 , .00 24. .00 O

HETATM 5125 0 HOH A2023 -14. .985 -1. ,296 23. , 176 1. .00 29. , 58 O

HETATM 5126 0 HOH A2024 -16. .812 -4. , 246 22. , 690 1. .00 28. , 13 O

HETATM 5127 0 HOH A2025 -15. .302 -8. , 648 28. , 312 1. .00 22. , 61 O

HETATM 5128 0 HOH A2026 -20. .710 0. .427 25. .126 1 , .00 36. .04 O

HETATM 5129 0 HOH A2027 -20. .860 -4. , 181 24. , 847 1. .00 23. , 91 O

HETATM 5130 0 HOH A2028 -21. .434 -8. , 329 32. , 833 1. .00 35. , 57 O

HETATM 5131 0 HOH A2029 -12. .251 -7. ,463 36. , 734 1. .00 22. , 97 O

HETATM 5132 0 HOH A2030 -12. .976 -11. , 408 27. , 978 1. .00 27. , 53 O

HETATM 5133 0 HOH A2031 -3. .387 0. .576 37. .085 1 , .00 24. .12 O

HETATM 5134 0 HOH A2032 -6. .941 -18. , 681 32. , 032 1. .00 34. ,29 O

HETATM 5135 0 HOH A2033 -3. .193 16. .847 35. .115 1 , .00 32. .77 O

HETATM 5136 0 HOH A2034 4. .225 8. .830 35. .186 1 , .00 22. .44 0

HETATM 5137 0 HOH A2035 -1. .286 10. .313 27. .528 1 , .00 27. .93 0

HETATM 5138 0 HOH A2036 -2. .098 3. .692 37. .318 1 , .00 24. .53 0

HETATM 5139 0 HOH A2037 -1. .912 -2. , 671 36. , 730 1. .00 30. , 92 0

HETATM 5140 0 HOH A2038 3. .458 2. .045 36. .765 1 , .00 23. .01 0

HETATM 5141 0 HOH A2039 0. .942 -1. , 609 40. , 707 1. .00 33. , 88 0

HETATM 5142 0 HOH A2040 6. .299 -8. ,117 34. , 963 1. .00 43. , 88 0

HETATM 5143 0 HOH A2041 16. .028 18. .730 35. .941 1 , .00 14. .46 0

HETATM 5144 0 HOH A2042 20. .321 19. .006 34. .650 1 , .00 27. .69 0

HETATM 5145 0 HOH A2043 22. .956 4. .655 23. .038 1 , .00 29. .34 0

HETATM 5146 0 HOH A2044 16. .531 -12. , 324 31. ,797 1. .00 31. ,86 0

HETATM 5147 0 HOH A2045 4. .805 -8. , 221 28. , 912 1. .00 41. , 99 0

HETATM 5148 0 HOH A2046 -1. .811 -12. , 147 34. , 656 1. .00 37. , 40 0

HETATM 5149 0 HOH A2047 -9. .091 -13. , 152 25. , 683 1. .00 32. , 52 0

HETATM 5150 0 HOH A2048 -7. .701 -17. , 319 29. , 627 1. .00 27. ,71 0

HETATM 5151 0 HOH A2049 -2. .279 -5. ,762 23. ,863 1. .00 18. , 98 0

HETATM 5152 0 HOH A2050 -0. .569 -7. , 259 28. , 903 1. .00 41. , 56 0

HETATM 5153 0 HOH A2051 -2. .618 -6. ,192 19. , 723 1. .00 34. ,29 0

HETATM 5154 0 HOH A2052 2. .882 9. .462 30. .856 1 , .00 22. .59 0

HETATM 5155 0 HOH A2053 3. .791 7. .396 32. .684 1 , .00 22. .32 0

HETATM 5156 0 HOH A2054 8. .760 7. .296 35. .929 1 , .00 31. .75 0

HETATM 5157 0 HOH A2055 26. .970 8. .351 40. .015 1 , .00 34. .42 0

HETATM 5158 0 HOH A2056 25. .935 8. .094 36. .870 1 , .00 35. .09 0

HETATM 5159 0 HOH A2057 23. .196 3. .437 29. .496 1 , .00 28. .83 0

HETATM 5160 0 HOH A2058 22. .978 10. .427 31. .756 1 , .00 23. .32 0

HETATM 5161 0 HOH A2059 26. .104 8. .995 26. .373 1 , .00 33. .36 0

HETATM 5162 0 HOH A2060 19. .091 5. .177 23. .035 1 , .00 26. .03 0

HETATM 5163 0 HOH A2061 6. .866 -0. , 318 19. , 252 1. .00 25. , 52 0

HETATM 5164 0 HOH A2062 2. .324 -4. , 964 25. , 424 1. .00 34. , 04 0

HETATM 5165 0 HOH A2063 16. .044 12. .386 22. .449 1 , .00 28. .83 0

HETATM 5166 0 HOH A2064 20. .403 6. .347 19. .645 1 , .00 30. .40 0

HETATM 5167 0 HOH A2065 9. .182 10. .247 18. .857 1 , .00 29. .49 0

HETATM 5168 0 HOH A2066 8. .579 10. .819 22. .486 1 , .00 29. .15 0

HETATM 5169 0 HOH A2067 9. .830 16. .634 26. .527 1 , .00 29. .48 0

HETATM 5170 0 HOH A2068 13. .718 18. .723 34. .659 1 , .00 16. .68 0 HETATM 5171 0 HOH A2069 17..589 14 ,.122 38 ,.232 1 ,.00 25,.57 O

HETATM 5172 0 HOH A2070 18. .205 17 , .348 35, .240 1 , .00 16, .79 O

HETATM 5173 0 HOH A2071 22. .353 17 , .207 33, .068 1 , .00 30 , .76 O

HETATM 5174 0 HOH A2072 21. .354 15, .640 29, .503 1 , .00 19, .44 O

HETATM 5175 0 HOH A2073 18. .932 16, .145 37 , .577 1 , .00 26, .18 O

HETATM 5176 0 HOH A2074 2. .138 9, .297 36, .081 1 , .00 35, .21 O

HETATM 5177 0 HOH B2001 -28. .109 -14. .196 10. .145 1. .00 27. .31 O

HETATM 5178 0 HOH B2002 -26. .826 -9. .807 23. .209 1. .00 25. .97 O

HETATM 5179 0 HOH B2003 -23. .276 -8. .997 23. .229 1. .00 24. .72 O

HETATM 5180 0 HOH B2004 -20. .590 -10. .535 26. .027 1. .00 25. .48 O

HETATM 5181 0 HOH B2005 -13. .029 -8. .465 19. .197 1. .00 28. .64 O

HETATM 5182 0 HOH B2006 -15. .328 -7. .097 20. .450 1. .00 25. .38 O

HETATM 5183 0 HOH B2007 -11. .525 -9. .373 21. .719 1. .00 21. .37 O

HETATM 5184 0 HOH B2008 -11. .033 -11. .137 26. .152 1. .00 33. .84 O

HETATM 5185 0 HOH B2009 -11. .364 -11. .949 20. .551 1. .00 33. .77 O

HETATM 5186 0 HOH B2010 -25. .567 -6. .974 22. .417 1. .00 36. .27 O

HETATM 5187 0 HOH B2011 -12. .811 -15. .876 22. .025 1. .00 17. .23 O

HETATM 5188 0 HOH B2012 -12. .852 -17. .327 32. .429 1. .00 28. .41 O

HETATM 5189 0 HOH B2013 -20. .751 -23. .522 13. .370 1. .00 42. .96 O

HETATM 5190 0 HOH B2014 -23. .987 -25. .910 28. .066 1. .00 26. .33 O

HETATM 5191 0 HOH B2015 -17. .348 -28. .695 27. .070 1. .00 24. .18 O

HETATM 5192 0 HOH B2016 -13. .678 -27. .798 24. .478 1. .00 18. .02 O

HETATM 5193 0 HOH B2017 -24. .794 -24. .927 22. .097 1. .00 24. .27 O

HETATM 5194 0 HOH B2018 -23. .359 -27. .508 19. .972 1. .00 28. .32 O

HETATM 5195 0 HOH B2019 -17. .538 -4. .227 20. .061 1. .00 29. .78 O

HETATM 5196 0 HOH B2020 -21. .875 -2. .328 15. .307 1. .00 31. .59 0

HETATM 5197 0 HOH B2021 -23. .928 -4. .274 14. .470 1. .00 17. .93 0

HETATM 5198 0 HOH B2022 -21. .585 -2. .105 12. .623 1. .00 38. .20 0

HETATM 5199 0 HOH B2023 8. .568 -27. .241 -22. .983 1. .00 35. .49 0

HETATM 5200 0 HOH B2024 -22. .930 -1. .971 21. .768 1. .00 24. .17 0

HETATM 5201 0 HOH B2025 -30. .478 -5. .431 18. .823 1. .00 30. .85 0

HETATM 5202 0 HOH B2026 -27. .284 -12. .633 12. .144 1. .00 20. .15 0

HETATM 5203 0 HOH B2027 -23. .247 -3. .758 10. .884 1. .00 30. .71 0

HETATM 5204 0 HOH B2028 -18. .823 -20. .910 12. .336 1. .00 20. .04 0

HETATM 5205 0 HOH B2029 -6. .456 -20. .323 27. .132 1. .00 39. .50 0

HETATM 5206 0 HOH B2030 -16. .567 -23. .351 13. .861 1. .00 18. .86 0

HETATM 5207 0 HOH B2031 -19. .215 -20. .001 8. .826 1. .00 28. .69 0

HETATM 5208 0 HOH B2032 -13. .927 -24. .631 8. .625 1. .00 15. .77 0

HETATM 5209 0 HOH B2033 12. .031 -22. .563 -0. .732 1. .00 38. .04 0

HETATM 5210 0 HOH B2034 -14. .190 -20. .700 1. .870 1. .00 35. .08 0

HETATM 5211 0 HOH B2035 -13. .493 -34. .577 -2. .955 1. .00 37. .63 0

HETATM 5212 0 HOH B2036 -1. .706 -31. .165 -11. .063 1. .00 34. .74 0

HETATM 5213 0 HOH B2037 2. .709 -24. .947 -13. .217 1. .00 34. .98 0

HETATM 5214 0 HOH B2038 -4. .661 -25. .311 -16. .106 1. .00 33. .47 0

HETATM 5215 0 HOH B2039 4. .020 -29. .098 -14. .447 1. .00 30. .29 0

HETATM 5216 0 HOH B2040 0. .156 -26. .656 -20. .401 1. .00 30. .00 0

HETATM 5217 0 HOH B2041 9. .486 -27. .376 -20. .573 1. .00 24. .94 0

HETATM 5218 0 HOH B2042 3. .544 -26. .235 -10. .656 1. .00 35. .63 0

HETATM 5219 0 HOH B2043 -0. .557 -18. .224 -8. .978 1. .00 29. .78 0

HETATM 5220 0 HOH B2044 7. .634 -20. .802 -6. .595 1. .00 39. .08 0

HETATM 5221 0 HOH B2045 8. .446 -24. .306 -1. .406 1. .00 30. .09 0

HETATM 5222 0 HOH B2046 -13. .176 -16. .066 -4. .263 1. .00 43. .41 0

HETATM 5223 0 HOH B2047 -18. .928 -17. .217 4. .527 1. .00 31. .92 0

HETATM 5224 0 HOH B2048 -21. .641 -13. .808 2. .195 1. .00 38. .05 0

HETATM 5225 0 HOH B2049 -22. .707 -10. .072 0. .327 1. .00 25. .73 0

HETATM 5226 0 HOH B2050 -11. .904 -8. .950 8. .122 1. .00 18. .36 0

HETATM 5227 0 HOH B2051 -3. .602 -8. .541 15. .224 1. .00 33. .88 0

HETATM 5228 0 HOH B2052 -9. .052 -5. .530 8. .084 1. .00 28. .03 0

HETATM 5229 0 HOH B2053 -3. .660 -10. .595 18. .175 1. .00 30. .93 0

HETATM 5230 0 HOH B2054 -6. .921 -23. .959 15. .032 1. .00 20. .30 0

HETATM 5231 0 HOH B2055 -8. .483 -24. .879 12. .643 1. .00 16. .58 0 HETATM 5232 O HOH B2056 1..994 -37..161 -2..601 1..00 32..02 O

HETATM 5233 O HOH B2057 3. .716 -28. .579 -3. .151 1. .00 21. .38 O

HETATM 5234 O HOH B2058 4. .604 -33. .792 1. .805 1. .00 18. .12 O

HETATM 5235 O HOH B2059 9. .643 -30. .734 -0. .601 1. .00 26. .23 O

HETATM 5236 O HOH B2060 12. .695 -31. .588 -2. .522 1. .00 26. .04 O

HETATM 5237 O HOH B2061 10. .950 -24. .469 1. .411 1. .00 29. .40 O

HETATM 5238 O HOH B2062 14. .940 -28. .792 4. .478 1. .00 40. .48 O

HETATM 5239 O HOH B2063 6. .406 -22. .808 1. .798 1. .00 20. .70 O

HETATM 5240 O HOH B2064 -0. .900 -12. .063 6. .497 1. .00 19. .93 O

HETATM 5241 O HOH B2065 -9. .797 -12. .421 5. .188 1. .00 27. .74 O

HETATM 5242 O HOH B2066 1. .323 -9. .890 7. .227 1. .00 32. .87 O

HETATM 5243 O HOH B2067 8. .352 -17. .498 6. .365 1. .00 30. .67 O

HETATM 5244 O HOH B2068 15. .368 -23. .895 7. .212 1. .00 37. .09 O

HETATM 5245 O HOH B2069 2. .805 -21. .099 13. .311 1. .00 21. .43 O

HETATM 5246 O HOH B2070 0. .704 -36. .413 13. .763 1. .00 23. .51 O

HETATM 5247 O HOH B2071 -2. .872 -33. .717 12. .736 1. .00 29. .32 O

HETATM 5248 O HOH B2072 2. .443 -38. .168 9. .401 1. .00 26. .73 O

HETATM 5249 O HOH B2073 -6. .072 -43. .842 -1. .946 1. .00 33. .74 O

HETATM 5250 O HOH B2074 3. .103 -14. .744 16. .986 1. .00 34. .50 O

HETATM 5251 O HOH B2075 5. .262 -11. .773 14. .723 1. .00 37. .82 O

HETATM 5252 O HOH B2076 8. .523 -19. .583 -2. .004 1. .00 36. .43 O

HETATM 5253 O HOH C2001 -27. .896 4 , .582 22 , .223 1 , .00 32 , .23 O

HETATM 5254 O HOH C2002 -25. .565 2 , .850 19, .924 1 , .00 36, .41 O

HETATM 5255 O HOH C2003 -26. .488 0 , .396 18 , .098 1 , .00 35, .11 O

HETATM 5256 O HOH C2004 -18. .148 -1. .881 21. .982 1. .00 28. .44 O

HETATM 5257 O HOH C2005 -15. .903 -1. .938 20. .365 1. .00 31. .42 O

HETATM 5258 O HOH C2006 -16. .455 0 , .585 22 , .633 1 , .00 30 , .53 0

HETATM 5259 0 HOH C2007 -21. .768 2 , .376 8 , .178 1 , .00 27 , .64 0

HETATM 5260 0 HOH C2008 -19. .629 0 , .416 8 , .196 1 , .00 40 , .91 0

HETATM 5261 0 HOH C2009 -20. .233 -2. .073 10. .547 1. .00 38. .69 0

HETATM 5262 0 HOH C2010 -33. .499 6, .246 1 , .315 1 , .00 39, .13 0

HETATM 5263 0 HOH C2011 -23. .548 4 , .520 23, .253 1 , .00 31 , .48 0

HETATM 5264 0 HOH C2012 -22. .963 8 , .839 -0. .306 1. .00 30. .00 0

HETATM 5265 0 HOH C2013 -17. .648 4 , .484 1 , .230 1 , .00 35, .42 0

HETATM 5266 0 HOH C2014 -20. .551 20 , .412 7 , .446 1 , .00 40 , .32 0

HETATM 5267 0 HOH C2015 -2. .791 31. .350 -7. .817 1. .00 30. .00 0

HETATM 5268 0 HOH C2016 3. .348 23, .901 0 , .802 1 , .00 37 , .17 0

HETATM 5269 0 HOH C2017 -10. .578 10 , .867 23, .437 1 , .00 26, .95 0

HETATM 5270 0 HOH C2018 -8. .457 8 , .826 14 , .281 1. .00 29. .27 0

HETATM 5271 0 HOH C2019 -10. .194 -1. .986 10. .832 1. .00 36. .12 0

HETATM 5272 0 HOH C2020 -9. .445 1 , .280 9, .176 1 , .00 39, .54 0

HETATM 5273 0 HOH C2021 -6. .231 6, .667 10 , .512 1 , .00 40 , .83 0

HETATM 5274 0 HOH C2022 -17. .486 9, .043 -1. .303 1. .00 41. .42 0

HETATM 5275 0 HOH C2023 -17. .450 11 , .980 -0. .730 1. .00 37. .00 0

HETATM 5276 0 HOH C2024 -16. .541 16, .773 -4. .042 1. .00 28. .77 0

HETATM 5277 0 HOH C2025 -18. .851 18 , .518 -7. .414 1. .00 30. .58 0

HETATM 5278 0 HOH C2026 -9. .908 28 , .291 -17. .159 1. .00 30. .17 0

HETATM 5279 0 HOH C2027 -7. .403 19, .442 -15. .511 1. .00 33. .76 0

HETATM 5280 0 HOH C2028 1. .586 12 , .486 -9. .899 1. .00 39. .29 0

HETATM 5281 0 HOH C2029 -16. .810 -20. .450 -3. .223 1. .00 42. .58 0

CONECT 94 355

CONECT 147 3700

CONECT 249 5058

CONECT 250 5058

CONECT 264 5058

CONECT 269 5058

CONECT 282 5058

CONECT 284 1832

CONECT 308 5058

CONECT 355 94

CONECT 358 364 CONECT 364 358 365

CONECT 365 364 366 368

CONECT 366 365 367 372

CONECT 367 366

CONECT 368 365 369

CONECT 369 368 370

CONECT 370 369 371

CONECT 371 370

CONECT 372 366

CONECT 413 1657

CONECT 622 626

CONECT 626 622 627

CONECT 627 626 628 630

CONECT 628 627 629 634

CONECT 629 628

CONECT 630 627 631

CONECT 631 630 632

CONECT 632 631 633

CONECT 633 632

CONECT 634 628

CONECT 951 1289

CONECT 990 1000

CONECT 1000 990 1001

CONECT 1001 1000 1002

CONECT 1002 1001 1003

CONECT 1003 1002

CONECT 1004 1001 1005

CONECT 1005 1004 1006

CONECT 1006 1005 1007

CONECT 1007 1006

CONECT 1008 1002

CONECT 1103 1109

CONECT 1109 1103 1110

CONECT 1110 1109 1111

CONECT 1111 1110 1112

CONECT 1112 1111

CONECT 1113 1110 1114

CONECT 1114 1113 1115

CONECT 1115 1114 1116

CONECT 1116 1115

CONECT 1117 1111

CONECT 1289 951

CONECT 1657 413

CONECT 1779 2040

CONECT 1832 284

CONECT 1934 5089

CONECT 1935 5089

CONECT 1949 5089

CONECT 1954 5089

CONECT 1967 5089

CONECT 1969 3563

CONECT 1993 5089

CONECT 2040 1779

CONECT 2043 2049

CONECT 2049 2043 2050

CONECT 2050 2049 2051

CONECT 2051 2050 2052

CONECT 2052 2051

CONECT 2053 2050 2054

CONECT 2054 2053 2055

CONECT 2055 2054 2056 CONECT 2056 2055

CONECT 2057 2051

CONECT 2095 3388

CONECT 2334 2338

CONECT 2338 2334 2339

CONECT 2339 2338 2340 2342

CONECT 2340 2339 2341 2346

CONECT 2341 2340

CONECT 2342 2339 2343

CONECT 2343 2342 2344

CONECT 2344 2343 2345

CONECT 2345 2344

CONECT 2346 2340

CONECT 2671 3018

CONECT 2710 2720

CONECT 2720 2710 2721

CONECT 2721 2720 2722 2724

CONECT 2722 2721 2723 2728

CONECT 2723 2722

CONECT 2724 2721 2725

CONECT 2725 2724 2726

CONECT 2726 2725 2727

CONECT 2727 2726

CONECT 2728 2722

CONECT 2817 2823 2831

CONECT 2823 2817 2824

CONECT 2824 2823 2825 2827

CONECT 2825 2824 2826 2839

CONECT 2826 2825

CONECT 2827 2824 2828

CONECT 2828 2827 2829

CONECT 2829 2828 2830

CONECT 2830 2829

CONECT 2831 2817 2832

CONECT 2832 2831 2833 2835

CONECT 2833 2832 2834 2839

CONECT 2834 2833

CONECT 2835 2832 2836

CONECT 2836 2835 2837

CONECT 2837 2836 2838

CONECT 2838 2837

CONECT 2839 2825 2833

CONECT 3018 2671

CONECT 3388 2095

CONECT 3510 3771

CONECT 3563 1969

CONECT 3665 5102

CONECT 3666 5102

CONECT 3680 5102

CONECT 3685 5102

CONECT 3698 5102

CONECT 3700 147

CONECT 3724 5102

CONECT 3771 3510

CONECT 3774 3780

CONECT 3780 3774 3781

CONECT 3781 3780 3782 3784

CONECT 3782 3781 3783 3788

CONECT 3783 3782

CONECT 3784 3781 3785

CONECT 3785 3784 3786 CONECT 3786 3785 3787

CONECT 3787 3786

CONECT 3788 3782

CONECT 3825 5036

CONECT 4026 4030

CONECT 4030 4026 4031

CONECT 4031 4030 4032

CONECT 4032 4031 4033

CONECT 4033 4032

CONECT 4034 4031 4035

CONECT 4035 4034 4036

CONECT 4036 4035 4037

CONECT 4037 4036

CONECT 4038 4032

CONECT 4349 4666

CONECT 4388 4398

CONECT 4398 4388 4399

CONECT 4399 4398 4400

CONECT 4400 4399 4401

CONECT 4401 4400

CONECT 4402 4399 4403

CONECT 4403 4402 4404

CONECT 4404 4403 4405

CONECT 4405 4404

CONECT 4406 4400

CONECT 4487 4493

CONECT 4493 4487 4494

CONECT 4494 4493 4495

CONECT 4495 4494 4496

CONECT 4496 4495

CONECT 4497 4494 4498

CONECT 4498 4497 4499

CONECT 4499 4498 4500

CONECT 4500 4499

CONECT 4501 4495

CONECT 4666 4349

CONECT 5036 3825

CONECT 5058 249 250 264 269

CONECT 5058 282 308

CONECT 5059 5060 5061

CONECT 5060 5059

CONECT 5061 5059 5062

CONECT 5062 5061

CONECT 5063 5061 5064

CONECT 5064 5063

CONECT 5065 5066 5067

CONECT 5066 5065

CONECT 5067 5065 5068

CONECT 5068 5067

CONECT 5069 5067 5070

CONECT 5070 5069

CONECT 5071 5072 5073

CONECT 5072 5071

CONECT 5073 5071 5074

CONECT 5074 5073

CONECT 5075 5073 5076

CONECT 5076 5075

CONECT 5077 5078 5079

CONECT 5078 5077

CONECT 5079 5077 5080

CONECT 5080 5079 CONECT 5081 5079 5082

CONECT 5082 5081

CONECT 5083 5084 5085

CONECT 5084 5083

CONECT 5085 5083 5086 5087

CONECT 5086 5085

CONECT 5087 5085 5088

CONECT 5088 5087

CONECT 5089 1934 1935 1949

CONECT 5089 1967 1993 5197

CONECT 5090 5091 5092

CONECT 5091 5090

CONECT 5092 5090 5093 5094

CONECT 5093 5092

CONECT 5094 5092 5095

CONECT 5095 5094

CONECT 5096 5097 5098

CONECT 5097 5096

CONECT 5098 5096 5099 5100

CONECT 5099 5098

CONECT 5100 5098 5101

CONECT 5101 5100

CONECT 5102 3665 3666 3680

CONECT 5102 3698 3724 5114

CONECT 5114 5102

CONECT 5127 5058

CONECT 5197 5089

MASTER 576 0 22 16 49 21 6 5278 221 60

END

11.5. Conclusion

Here the Inventors used the pHLsec plasmid system to produce a relatively large (90 KDa) and complex homotrimer containing 12 intra- and inter-chain disulfide bonds, in high yield and in native and Se-Met-labeled form. Incorporation of Se-Met was efficient, this being crucial for the structure determination of CPI I His for which there are no homologues in the protein data bank. Finally, three crystal forms were obtained, one of which diffracted X-rays to up to 1 .7 A resolution, thus paving the way for the first structure determination of this important protein domain.

In conclusion, the long awaited structure of the procollagen I I I C-propeptide trimer presented here provides a paradigm for this family of protein domains with key implications for human disease. It provides a structural basis for interpreting the effects of new C-propeptide mutations in genetic disorders, and also for the development of new anti-fibrotic therapies aimed at disrupting either procollagen trimerization or C- propeptide interactions with other proteins involved in the regulation of collagen fibril formation.

EXAMPLE 2: X-ray scattering and site-directed mutagenesis of the procollagen III C-propeptide trimer (CPIII) : CUB1 CUB2 PCPE-1 complex Tight regulation of collagen fibril deposition in the extracellular matrix is essential for normal tissue homeostasis and repair. A key regulatory step in the assem bly of col lagen fi brils is the C-terminal proteolytic processing of soluble procollagen precursors. This step, normally carried out by bone morphogenetic protein-1/tolloid-like proteinases (BTPs), is itself subject to regulation by procollagen C- proteinase enhancer proteins (PCPEs) which can increase BTP activity, in a substrate specific man ner, u p to 20-fold. Here the inventors show, by small angle X-ray scattering, that PCPE-1 binds to the stalk region of the procollagen C-propeptide trimer, at the junction with the base region, thus facilitating propeptide cleavage by BTPs. Site-directed mutagenesis reveals that this binding involves highly conserved, surface exposed lysine residues in the stalk/base regions of the C-propeptide trimer, and also aspartate residues involved in Ca²⁺ coordination in the CU B1 and CUB2 domains of PCPE-1 (CUB: complement C1 r/C1 s, Uegf, Bmp1 ). Together with detailed kinetics analysis, these results provide new insights into the mechanism of action of PCPEs and suggest possible strategies for the development of novel anti-fibrotic therapies. /. MA TERIALS AND METHODS

1.1. Molecular biology

All recombinant proteins were human forms. Mutations were introduced using the QuikChange XL site-directed mutagenesis kit from Stratagene. DNA sequences encoding CPI II-His-Bac and CPII I-Long-Bac were amplified by PCR from the N306Q mini-procollagen II I construct in pCEP4 (Vadon-Le Goff et al., 201 1 ). The resulting fragments were inserted into the Sacl l/Xhol sites of the pBAC3 (Novagen) vector, in frame with an N-terminal 6xHis-tag. For the preparation of CUB1 CUB2-Bac, first the T31A mutation was introduced into full-length PCPE-1 in pBlueScriptSK⁺ (Moali et al., 2005) to eliminate the N-glycosylation site. Following amplification, the region encoding CUB1 CUB2 was inserted into the BamHI/Xhol sites of the pBAC1 (Novagen) vector, including a C-terminal 6xHis-tag. Recombinant baculoviruses were obtained using the BacMagic-2 kit (Novagen) according to the manufacturer's protocol. CPIII-Long, CUB1 CUB2 and their mutated forms were also produced by transient transfection in 293 T cells (and hence referred to as CPIII-Long-293 or CUB1 CUB2-293) using the pHLsec plasmid (Aricescu et al.; 2006). For this, the CPIII-Long encoding region was amplified from the CPIII-Long-pBAC3 plasmid and inserted into the Agel/Xhol sites of pHLsec. Similarly, the CUB1 CUB2 encoding region was amplified from the CUB1 CUB2-pBAC1 plasmid and inserted into the Age1/Kpn1 sites of pHLsec. Mutations in CPIII-Long-293 and CUB1 CUB2-293 were generated from these pHLsec constructs.

1.2. Protein production and purification

PCPE-1 , PCPE-1-His, mini-procollagen III and BMP-1-FLAG (referred to as BMP- 1 in the text) were produced in 293-EBNA cells then purified, as described (Moali et al., 2005; Blanc et al., 2007). For expression of CPIII-His-Bac, CPIII-Long-Bac and CUB1 CUB2-Bac, Trichoplusia ni (High Five™ BTI-TN-5B1-4; Invitrogen) insect cells were cultured as described (Vadon-Le Goff et al., 201 1 ). When the cell density reached 1x10⁶ cells/ml, cells were infected with recombinant baculovirus using multiplicities of infection (MOI) of 1 for CPIII-His-Bac and CPIII-Long-Bac or 5 for CUB1 CUB2-Bac. After 3 days (for CPIII-His-Bac and CPIII-Long-Bac) or 4 days (for CUB1 CUB2-Bac) of infection, the culture medium was collected and the pH adjusted to 6.5. Subsequent purification was as described for CPIII-His-Bac (Vadon-Le Goff et al., 201 1 ). Production of CPIII-Long-293, and its mutants, and subsequent purification, are as described above for CPIIIHis-293 (Example 1 ). Production of CUB1 CUB2-293 was similar, except that a Superdex 75 16/60 column was used instead of a Superdex 200 16/60 column. 1.3. Characterization, interactions and kinetics

Circular dichroism measurements were carried out as described by Bekhouche et al. (2010). To investigate possible conformational changes on mixing, proteins were analyzed separately then mixed in a 1 :1 molar ratio and the measured mean residue weight molar ellipticities for the mixtures compared with those calculated from the sum of the individual spectra weighted according to molecular mass.

To study the CPIII/PCPE-1 complex by gel filtration, 250 μΙ aliquots of PCPE-1 and CPU I (each at 833 nM) were first analyzed separately on a Superdex 200 HR10/30 column (GE Healthcare), at room temperature, in 20 mM HEPES pH 7.4, 0.15 M NaCI, 5 mM CaCI₂. CPIII was then mixed with an excess of PCPE-1 and, following incubation for 30 min at room temperature, analyzed on the same column in the same conditions. Fractions were analyzed by SDS-PAGE.

Surface plasmon resonance experiments were performed using a Biacore T100 (GE Healthcare) at the Protein Production and Analysis facility of the UMS3444 (Lyon). Immobilization of PCPE-1-His or CPIII-Long, regeneration of sensor chips and analysis of kinetics were as previously described (Kronenberg et al., 2009; Blanc et al., 2007). Sensorgrams were recorded at 25°C using 10 mM HEPES pH 7.4, 0.15 M NaCI, 5 mM CaCI₂, 0.05 % P-20 as running buffer.

BMP-1 activity, in the presence and absence of PCPE-1 equimolar with respect to substrate, was measured at 37 °C in reaction volumes of 20 to 50 μΙ, in 50 mM HEPES pH 7.4, 0.15 M NaCI, 5 mM CaCI₂, 0.02% Brij-35, using CPIII-Long-293, at the specified concentrations. For enzyme kinetics, the substrate concentration was in the range 0 to 3000 nM, and in all cases incubation conditions were adjusted in order to remain within the linear region of the plot of amount of product released as a function of time. Reactions were stopped by the addition of EDTA and Laemmli sample buffer then reaction mixtures were analyzed by SDS-PAGE (using 4-20 % gradient gels; in reducing conditions) followed by Sypro Ruby staining and quantitation using a Molecular Dynamics Storm 860 imager (Bekhouche et al., 2010).

1.4. Structural analysis

Prior to small angle X-ray scattering analysis, samples (proteins and complexes) were further purified by gel filtration on a Superdex 200 HR16/60 prep grade column (GE Healthcare), equilibrated in 20 mM Hepes pH 7,4, 150 mM NaCI, 5 mM CaCI₂, 5 % glycerol. Experiments were carried out on the SWING beamline at the SOLEIL synchrotron (David et al., 2009), in the Q range 0.01 to 0.50 A^"1, where Q = 4nsin(9)/A, 2Θ is the scattering angle and λ = 1 .03 A is the X-ray wavelength. Immediately prior to SAXS analysis, all samples (proteins and complexes) were passed through an in-line gel filtration column (David et al., 2009). Scattering patterns were recorded every 1 .5 sec. Following data reduction and subtraction of buffer scattering, sample homogeneity within each peak was first checked by Guinier analysis (R_g constant) then data sets were pooled. Particle mass was calculated from the scattering intensity extrapolated to zero angle, using water as a reference (Orthaber et al., 2000) and a partial specific volume of 0.7425 cm³ g^"1 (Mylonas et al., 2007). Distance distribution functions p(r) were calculated using the program GNOM (Svergun, 1992). For ab initio shape determination, the programs DAMMIF (Franke et al., 2009), DAMMIN (Svergun, 1999), GASBOR (Svergun et al., 2001 ) and MONSA (Petoukhov et al., 2006)) were used. The models generated by MONSA for the individual molecules were very similar to those generated by DAMMIN.

Table 5. Summary of structural parameters determined from the small angle X-ray scattering data for individual proteins and complexes. Errors for R_g and kDa(obs) are standard deviations (N at least 10) based on estimates derived from Guinier plots. Errors in D_max are based on multiple GNOM runs. Typical χ² values are shown for the ab initio modelling. //. RESULTS

II.1. Structure of the PCPE- 1/CPIII complex

The inventors recently showed that the action of PCPE-1 relies solely on its binding to the C-propeptide region of the procollagen molecule (Vadon-Le Goff et al., 201 1 ). Since the corresponding dissociation constant (K_D) is in the nanomolar range, the inventors reasoned that it should be possible to isolate the PCPE-1 /C-propeptide trimer complex. As expected (Fig. 29A), when CPU I was first incubated with an excess of PCPE-1 then analyzed by gel filtration, the complex migrated ahead of the elution position of CPIII and could be separated from free PCPE-1 .

To determine the low resolution structure of the complex, and hence localize the PCPE binding site on the CPIII molecule, the inventors used small angle X-ray scattering (SAXS). For these studies, the inventors used CPIII-His-Bac (Fig. 24, consisting of the human procollagen III C-propeptide mutated at the single N- glycosylation site and with an N-terminal His₆-tag) as well as a longer construct called CPIII-Long-Bac (like CPIII-His-Bac but also including the last three GXY triplets of the triple-helical region, as well as the entire C-telopeptide). The inventors also produced a non-glycosylated form of the PCPE-1 CUB1 CUB2 region (called CUB1 CUB2-Bac), more suitable for structural studies, using a baculovirus expression system. For data collection, CUB1 CUB2-Bac, CPIII-His and CPIII-Long were first analyzed individually and then in the form of complexes (CUB1 CUB2-Bac with either CPIII-His-Bac or CPIII- Long-Bac). Immediately prior to SAXS analysis on the SWING beamline (David et al., 2009) at the SOLEIL synchrotron, all samples (proteins and complexes) were passed through an in-line gel filtration column. As shown in Table 5, by extrapolation of the scattering intensity to zero angle, all molecules (CUB1 CUB2-Bac, CPIII-His-Bac and CPIII-Long-Bac) behaved as monomers in solution, with the expected molecular masses. Table 5 also shows the observed values for R_g (radius of gyration), determined from Guinier plots, as well as maximum particle diameters D_max, determined from the distance distribution functions p(r) (Fig. 30).

Shown in the upper part of Fig. 24A are the averaged shapes determined for the different molecules from the SAXS data. For each molecule, first 10 individual ab initio shape determinations were made (without symmetry restrictions) using the program DAMMIF (Franke et al., 2009) and then averaged shapes were calculated using DAMAVER (Volkov et al., 2003). For CPIII-His, the ab initio shape consisted of a globular trimeric region connected to a short stalk, consistent with the high resolution structure of CPIII determined above (Example 1 ). CPIII-Long had a similar shape to CPIII-His, except that the molecule was some 22 A greater in length, as reflected in the D_max values (Table 5), due to the increased length of the stalk region. This is due to the additional presence of the C-telopeptide and the last three triplets of the triple-helical region in CPIII-Long that are absent in CPIII-His. This greater size of CPIII-Long was also reflected in the observed increase in the radius of gyration R_g, compared to CPIII- His (Table 5). Individual shape determinations for CUB1 CUB2-Bac, CPIII-His and CPIII-Long are shown in Fig. 31. Within each group, shapes were similar, as shown by the average normalized spatial discrepancy (NSD) values (Kozin et al., 2001 ) (Table 5). Fits to the scattering data were good, as illustrated in Fig. 24A, with corresponding chi-squared values given in Table 5.

When the different complexes were examined by SAXS, in both cases estimates of the molecular mass were consistent with the formation of complexes with a 1 :1 stoichiometry (Table 5). In addition, comparison of R_g and D_max values gave early indications about the localization of CUB1 CUB2-Bac on its binding partner (CPU l-His- Bac or CPIII-Long-Bac; Table 5). For both complexes, there was no change in D_max on CUB1 CUB2-Bac binding compared to CPIII-His-Bac or CPIII-Long-Bac alone (see Fig. 30 for the p(r) curves). In addition, there was little change in R_g. This shows that CUB1 CUB2-Bac binds to a site on its binding partner that is relatively central, i.e. changing neither the overall length of the particle nor the radial distribution of mass.

In order to further localize the CUB1 CUB2-Bac binding site, the inventors used the program MONSA to build ab initio shapes of the complexes taking into account the scattering curves for the complex as well as for its individual components (Petouchkov et al., 2006). As shown in Fig. 24B, this resulted in shapes where CUB1 CUB2-Bac was bound along the stalk of the CPU I trimer, with one end in contact with the globular domain, in both CPIII-His-Bac and CPIII-Long-Bac. For CPIII-His-Bac, CUB1 CUB2- Bac was bound in almost all (> 90 %) cases in register with the foot of the CPU I stalk, i.e. at the BMP-1 cleavage site (Fig. 24B, Fig. 32A). In contrast, for CPIII-Long-Bac, the tip of the stalk was always visible (Fig. 24B, Fig. 32B). This is consistent with the additional presence of the C-telopeptide at the end of the triple-helical region in CPIII- Long-Bac. For the complexes, again the individual shape determinations were very similar, with good fits to the scattering data (Fig. 24B, Table 5). Use of the program MONSA assumes that there were no major conformational changes in either partner on formation of the complex. To check this, the inventors measured the CD spectra of equimolar concentrations of CUB1 CUB2-Bac with CPIII-Long both before and after mixing. The CD spectra of the summed individual spectra and of the mixture were found to be similar, showing the absence of major changes in secondary structure (Fig. 29B).

The inventors conclude that the CUB1 CUB2 fragment of PCPE-1 binds to the stalk region of the procollagen I II C-propeptide trimer, at the junction with the globular region.

11.2. Identification of critical residues

The inventors previously identified critical residues in the CUB1 domain of PCPE-1 required for binding to CPIII (Blanc et al., 2007). These include a surface exposed phenylalanine residue that is unique to the CUB1 domains of PCPEs, as well as two aspartate residues that are likely, by analogy with CUB domain containing proteins of known structure, to be involved in Ca²⁺ coordination. Here the inventors modeled the structure of the CUB2 domain of PCPE-1 and identified two corresponding aspartate residues, D191 and D233, also likely to be involved in Ca²⁺ coordination (Fig. 25A). The inventors then expressed the CUB1 CUB2 fragment, in mammalian 293T cells, before and after site-directed mutagenesis of D191 to alanine.. As shown in Fig. 25B, when tested for enhancing activity in the presence of BMP-1 using CPIII-Long-293 as substrate, CUB1 CUB2-293 containing the D191A mutation was no longer able to enhance BMP-1 activity. In contrast, non-mutated CUB1 CUB2-293 showed enhancing activity as expected, and the amount of enhancement was identical to that of full length PCPE-1-293, confirming that the NTR domain does not contribute to enhancing activity (Kronenberg et al., 2009). In addition, by surface plasmon resonance, the D191A mutant was found to be unable to bind to CPIII-Long-293, unlike non-mutated CUB1 CUB2-293 which bound in a concentration dependent manner (Fig. 25C). These data show that an aspartate residue most likely to be involved in Ca²⁺ coordination in CUB2 is also required for PCPE enhancing activity, as previously shown for corresponding aspartate residues in the CUB1 domain (Blanc et al., 2009).

The inventors looked for putative interacting residues in the region of CPIII identified by SAXS as the PCPE binding site. Sequence alignment among different procollagen types and species using the UniProt-SwissProt database (Fig. 33) revealed three highly conserved lysine residues, at position 18 (in the stalk region) and at positions 35 and 45 (in the base region) as possible CPIII binding sites. These residues were then individually mutated and their effects on PCPE binding and enhancing activity determined. As shown in Fig. 26A, as with wild type CPIII-Long-293, cleavage of the K45Q mutant by BMP-1 , leading to release of the C-propeptides, continued to be enhanced by PCPE-1 . In contrast, with both the K18A and K35Q mutants, PCPE-1 no longer had any effect on basal BMP-1 activity. These effects were perfectly mirrored in the binding assays (Fig. 26B). By surface plasmon resonance (Biacore), the K45Q mutation had no effect on PCPE-1 binding to CPIII-Long-293, compared to wild-type. In contrast, binding was completely abrogated by both the K18A and K35Q mutations. The inventors conclude that lysines 18 and 35 are required for the interaction of PCPE-1 with CPIII, thus reinforcing the SAXS data indicating binding of the CUB1 CUB2 region of PCPE-1 to the CPIII stalk region, at the junction with the base. Fig. 27A shows the positions of the mutated lysines in the three- dimensional structure of CPIII. 11.3. Enzyme kinetics

Finally, to gain further insights into the mechanism of PCPE enhancing activity, the inventors carried out detailed kinetic analysis of the cleavage of CPIII-Long by BMP-1 in the presence and absence of PCPE-1 . Reaction rate data are shown in Fig. 28. In the presence of PCPE-1 (in equimolar ratio with respect to substrate), a k_cat of 1 10 ± 10 min^"1 and a K_m 2452 ± 379 nM were found. In the absence of PCPE-1 , it was difficult to obtain accurate kinetic constants due to the very high K_M and hence the need to work at prohibitively high substrate concentrations. The inventors obtained a k_cat of 26 ± 17 min^"1 and a K_m of 7289 ± 6109 nM. This shows that there is a significant increase in k_cat in the presence of PCPE-1 , though the effect on the K_m could not be determined with sufficient precision.

11.4. Conclusion and discussion

Here, by a combination of small angle X-ray scattering and site-directed mutagenesis, the inventors localized the binding site of PCPE-1 on the C-propeptide region of procollagen III (CPIII). The data show that the CUB1 CUB2 fragment of PCPE-1 binds to the stalk/base region of CPIII, and involves two conserved lysine residues in the latter (i.e. 2 per chain or 6 per trimer), one in the coiled-coil part of the stalk, the other at the junction with the base region. Both lysines are conserved in the C-propeptide regions of all the main fibrillar procollagens, with the notable exception of the proa1 (V) chain, for which C-propeptide cleavage appears to be unaffected by PCPE-1.

The inventors previously showed that both the binding and enhancing activities of PCPE-1 require a pair of aspartate residues in the CUB1 domain that are universally conserved in all the CUB domains of human PCPEs and BTPs (Blanc et al., 2007). Here the inventors show that one of the corresponding aspartates in the CUB2 domain is also essential for binding and enhancing activity. In addition to binding Ca²⁺, two of these conserved residues (the glutamate and the second aspartate) have surface exposed carboxy oxygens, which in the case of the cubulin : intrinsic factor-cobalamin complex, have been shown to participate in interactions with surface lysine or arginine residues on their cognate binding partner. The inventors show here that such interactions also occur in the binding of PCPE-1 to the procollagen C-propeptide, thus extending the repertoire of known protein-protein interactions involving Ca²⁺ binding CUB domains and exposed basic residues on their binding partners.

The observation that the stoichiometry of the PCPE-1 :CPIII interaction is 1 :1 (i.e. one molecule of PCPE-1 per C-propeptide trimer) is intriguing. The inventors show here that binding of the CUB1 CUB2 region of PCPE-1 to CPIII involves sites on both the CUB1 and CUB2 domains, as well as lysines K18 and K35 in the stalk/base region of CPIII, these residues being present in each of the three chains. At the moment, it is not known whether binding of CUB1 CUB2 to CPIII involves more than one chain of CPIII. It is possible, for example, that the interaction zone comprises the two CUB domains of CUB1 CUB2 and lysines K18 and K35 on a single chain of CPIII, as shown in Fig. 27B. Alternatively, the interaction zone could comprise one CUB domain binding to K18 on one chain, and the other CUB domain binding to K35 on another chain. Whatever the topology of the interaction however, due to the trimeric nature of CPIII, a single CUB1 CUB2 molecule should in theory have a choice of three ways in which to bind to CPIII. The inventors suggest that only one CUB1 CUB2 molecule is bound because of steric exclusion reasons, such that binding of one molecule of CUB1 CUB2 to CPIII blocks binding of any additional PCPE molecules. In this way, binding of one CUB1 CUB2 molecule to one C-propeptide trimer would introduce marked asymmetry in the complex, in addition to that detected above in CPIII itself (Example 1 ). The presence of such asymmetry may provide clues to the mechanism of enhancing activity.

What then is the mechanism of action of PCPE? Two possible consequences of PCPE-1 binding to the C-propeptide trimer can be envisaged, involving changes in the affinity of the enzyme for its substrate or changes in catalytic efficiency. Concerning the first possibility, complex formation might create a new interaction surface, involving both substrate and enhancer, which increases the affinity of BMP-1 for its substrate. Since the inventors were unable to measure the effect of PCPE-1 on the Michaelis- Mentin constant K_m for BMP-1 , and since the K_m itself includes the dissociation constant k_cat, which increases in the presence of PCPE-1 , this possibility cannot be excluded. For comparison, previous observations (Adar et al., 1986) using radioactively labeled chick procollagen I with BMP-1 and PCPE-1 (mostly the 34-36 kDa CUB1 CUB2 fragment) from mouse 3T6 cells, have reported a 20-fold increase in kcat and a 16-fold increase in K_m.

Concerning the second possibility, PCPE binding might lead to a change in structure of the enzyme:substrate complex, giving rise to the observed increase in catalytic activity. The proposed conformational change could occur in the substrate, in the enzyme, or both. Comparison with other proteolytic mechanisms provides possible clues. For example, there is evidence that cleavage of collagen molecules by at least some MMPs requires a conformational change in the substrate, the triple-helical structure being too large to enter the active site cleft (Chung et al., 2004; Tarn et al., 2004). Non-catalytic domains such as the linker/haemopexin domain in MMP-1 or MMP-14, or the fibronectin ll-like collagen binding domain in MMP-2, appear to stabilize partially unwound forms of the substrate, thereby exposing individual polypeptide chains (Nerenberg et al., 2008; Manka et al., 2012). This also could be a role for PCPEs, to interact with the trimeric substrate (in this case the coiled coil stalk of the C-propeptide trimer) and present individual chains for cleavage by BMP-1 /tolloid- like proteinases. This is consistent with the observed binding of PCPE-1 to the stalk region of CPIII, close to the BMP-1 cleavage site. This model would also be consistent with the observation that PCPE-1 does not enhance BMP-1 cleavage of individual procollagen chains, which presumably would already be exposed to the proteinase (Moali et al., 2005). In contrast, the inventors found no evidence of a change in secondary structure of the substrate on PCPE binding, albeit that small changes would not by detectable by circular dichroism. Alternatively, formation of the procollagen:PCPE complex might lead to a conformational change in the proteinase, thereby increasing catalytic efficiency. Recent observations on the low resolution structures of BMP-1 , mTId (mammalian tolloid) and mTLL-1 (mammalian tolloid-like 1 ) suggest a substrate exclusion mechanism of enzyme regulation involving the non- catalytic CUB and EGF (epidermal growth factor) domains (Berry et al., 2009 and 2010). Interaction with the procollagen:PCPE complex might therefore lead to a conformational change in BMP-1 that increases catalytic efficiency.

Identification of the site of interaction of PCPE-1 with the procollagen substrate could thus have important implications for the development of novel strategies to prevent the excessive accumulation of collagen seen in fibrotic diseases. Notably in view of the substrate specific nature of PCPE enhancing activity, which appears to be limited to C-terminal processing of the major fibrillar procollagens, strategies aimed at blocking the action of PCPEs would seem to be promising, especially as there is evidence of PCPE up-regulation in animal models of liver and cardiac fibrosis (Ogata et al., 1997; Kesseler-lcekson et al., 2006; Baicu et al., 2012). REFERENCES

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Claims

A crystal comprising a procollagen III C-propeptide trimer.

The crystal of claim 1 , wherein a monomer of said procollagen II I C-propeptide trimer is of sequence selected from SEQ ID N° 1 , SEQ ID N°2, SEQ ID N°6 and mutated sequences thereof.

The crystal of any one of claims 1 to 2, wherein: a) space group is P2₁2₁2₁, unit cell parameters are a = 76.5 A; b = 90.4 A, c =102.4 A, α β and γ= 90.0 degrees, and one procollagen III C-propeptide trimer is included in an asymmetric unit (crystal a), or b) space group is P321 , unit cell parameters are a = 86.1 A; b = 86.1 A, c = 73 A, a and β = 90.0 degrees and γ= 120.0 degrees, and one monomer of said procollagen III C-propeptide trimer is included in an asymmetric unit (crystal b), or c) space group is P2₁2₁2_1-Se, unit cell parameters are a = 83.9 A; b = 89.3 A, c =101.5 A, α β and γ= 90.0 degrees, and one procollagen III C-propeptide trimer is included in an asymmetric unit, said procollagen III C-propeptide being selenomethionylated (crystal c).

The crystal of claim 3, wherein the atomic coordinates of crystal a) are defined in Table A, the atomic coordinates of crystal b) are defined in Table B, or the atomic coordinates of crystal c) are defined in Table C.

The crystal of any one of claims 1 to 4, wherein said procollagen III C-propeptide trimer is further complexed with the CUB1 CUB2 domains of Procollagen C- proteinase Enhancer 1 (PCPE1 ).

The crystal of claim 5, wherein the CUB1 CUB2 domains of Procollagen C- proteinase Enhancer 1 are of sequence selected from SEQ ID N°3 and SEQ ID N°4.

A method for producing a crystal comprising a procollagen III C-propeptide trimer, comprising the following steps: a) providing a protein solution comprising a procollagen III C-propeptide trimer, wherein a monomer of procollagen III C-propeptide is as defined in claim 2; b) subjecting said protein solution to conditions which promote optimal crystallization.

The method according to claim 7, wherein the procollagen III C-propeptide trimer of step a) is further complexed with the CUB1 CUB2 domains Procollagen C- proteinase Enhancer 1 (PCPE1 ), said domains being as defined in claim 6.

A method for identifying a compound modulating the trimerization of procollagen III C-propeptide, comprising the steps of: a) providing the atomic coordinates of Table A, Table B or Table C as defined in claim 4 or a combination thereof, thereby defining a three-dimensional structure of the procollagen III C-propeptide trimer ; b) using said three-dimensional structure to design or select a compound modulating the trimerization of procollagen III C-propeptide by computer modeling; c) providing said compound.

10. The method of claim 9, said method further comprising the step: d) physically contacting said compound with procollagen III C-propeptide to determine the ability of said compound to modulate the trimerization of procollagen III C-propeptide.

1 1 . A method for identifying a compound modulating the binding of Procollagen C- proteinase Enhancer 1 (PCPE1 ) to the procollagen III C-propeptide trimer, comprising the steps of: a) providing the atomic coordinates of the crystal defined in claim 5 or 6, thereby defining a three-dimensional structure of the complex procollagen III C-propeptide trimer / CUB1 CUB2 domains of Procollagen C-proteinase Enhancer 1 ; b) using said three-dimensional structure to design or select a compound modulating the binding of the CUB1 CUB2 domains of Procollagen C- proteinase Enhancer 1 to the procollagen III C-propeptide trimer by computer modeling; c) providing said compound.

12. The method of claim 1 1 , said method further comprising the step: d) physically contacting said compound with a procollagen III C-propeptide trimer and Procollagen C-proteinase Enhancer 1 to determine the ability of said compound to modulate the binding of Procollagen C-proteinase Enhancer 1 (PCPE1 ) to the procollagen III C-propeptide trimer.

13. The method of any one of claim 1 1 to 12, wherein said compound binds to at least one lysine residue of the procollagen III C-propeptide selected from the group of lysine residues at position 18, 35, 45 and 52 of sequence SEQ ID N°1 , and of lysine residues at position 29, 46, 56 and 63 of sequence SEQ ID N°2 or SEQ ID N°6.