DE69613481T2 - Hydrogele auf basis von dreiblockcopolymerisate, ihre herstellung und ihre verwendung - Google Patents

Hydrogele auf basis von dreiblockcopolymerisate, ihre herstellung und ihre verwendung

Info

Publication number
DE69613481T2
DE69613481T2 DE69613481T DE69613481T DE69613481T2 DE 69613481 T2 DE69613481 T2 DE 69613481T2 DE 69613481 T DE69613481 T DE 69613481T DE 69613481 T DE69613481 T DE 69613481T DE 69613481 T2 DE69613481 T2 DE 69613481T2
Authority
DE
Germany
Prior art keywords
copolymer
water
retaining
production
ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69613481T
Other languages
English (en)
Other versions
DE69613481D1 (de
Inventor
Michel Vert
Suming Li
Iliya Rashkov
Jose-Luis Espartero-Sanchez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE69613481D1 publication Critical patent/DE69613481D1/de
Application granted granted Critical
Publication of DE69613481T2 publication Critical patent/DE69613481T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/916—Hydrogel compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69613481T 1995-11-29 1996-11-29 Hydrogele auf basis von dreiblockcopolymerisate, ihre herstellung und ihre verwendung Expired - Lifetime DE69613481T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9514144A FR2741628B1 (fr) 1995-11-29 1995-11-29 Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs
PCT/FR1996/001901 WO1997019973A1 (fr) 1995-11-29 1996-11-29 Nouveaux hydrogels a base de copolymeres trisequences, leur preparation et leur application

Publications (2)

Publication Number Publication Date
DE69613481D1 DE69613481D1 (de) 2001-07-26
DE69613481T2 true DE69613481T2 (de) 2002-04-25

Family

ID=9485003

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69613481T Expired - Lifetime DE69613481T2 (de) 1995-11-29 1996-11-29 Hydrogele auf basis von dreiblockcopolymerisate, ihre herstellung und ihre verwendung

Country Status (11)

Country Link
US (1) US6350812B1 (de)
EP (1) EP0863933B1 (de)
JP (2) JP4521067B2 (de)
AT (1) ATE202373T1 (de)
DE (1) DE69613481T2 (de)
DK (1) DK0863933T3 (de)
ES (1) ES2159767T3 (de)
FR (1) FR2741628B1 (de)
GR (1) GR3036586T3 (de)
PT (1) PT863933E (de)
WO (1) WO1997019973A1 (de)

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US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US6566406B1 (en) 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
US6316522B1 (en) * 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
JP4656725B2 (ja) * 1997-10-03 2011-03-23 プロセリックス・ソルト・レイク・シティ，インコーポレーテッド 逆熱的ゲル化特性を有する生分解性低分子量トリブロックポリ（ラクチド−ｃｏ−グリコリド）−ポリエチレングリコールコポリマー
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6222091B1 (en) * 1997-11-19 2001-04-24 Basf Aktiengesellschaft Multicomponent superabsorbent gel particles
US6072101A (en) * 1997-11-19 2000-06-06 Amcol International Corporation Multicomponent superabsorbent gel particles
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US7347850B2 (en) 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
CA2402546C (en) * 2000-03-15 2009-06-02 Yu-Ling Cheng Environment responsive gelling copolymer
US7160931B2 (en) 2000-03-15 2007-01-09 Yu-Ling Cheng Thermally reversible implant and filler
US7193007B2 (en) 2000-03-15 2007-03-20 Yu-Ling Cheng Environment responsive gelling copolymer
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US7347988B2 (en) * 2001-11-15 2008-03-25 University Of North Texas Synthesis, uses and compositions of crystal hydrogels
BR0305034A (pt) * 2002-06-06 2004-07-20 Nippon Catalytic Chem Ind Composição para absorção de água, processo para produção da mesma, absorvente e produto absorvente
WO2003104307A1 (en) * 2002-06-10 2003-12-18 Rhodia Inc Phase-separated composition comprising two miscible solvents, and use thereof in a process for making capsules
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20070054985A1 (en) * 2003-06-10 2007-03-08 Mathieu Joanicot Phase-separated composition comprising two miscible solvents, and use thereof in a process for making capsules
US20060018872A1 (en) * 2004-06-16 2006-01-26 Tew Gregory N Poly(lactic acid) copolymer hydrogels and related methods of drug delivery
US8357391B2 (en) * 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
US8304468B2 (en) * 2005-09-07 2012-11-06 Dsm Ip Assets B.V. Polymers comprising thioester bonds
FR2891746B1 (fr) * 2005-10-11 2008-01-11 Centre Nat Rech Scient Matrice poreuse biocompatible et biodegradable notamment utile pour la construction cellulaire
FR2893943B1 (fr) 2005-11-28 2011-08-19 Centre Nat Rech Scient Procede de preparation de copolymeres par polymerisation anionique sans solvant
CN101400718A (zh) 2006-03-14 2009-04-01 株式会社Jms 生物体吸收性材料制造用材料、生物体吸收性材料及其制造方法
JP2008069324A (ja) * 2006-09-15 2008-03-27 Mitsui Chemicals Inc 生分解性を有する水環境応答型ポリマーを含む水崩壊性組成物および水崩壊性成形体
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
JP5171146B2 (ja) * 2007-07-27 2013-03-27 学校法人 関西大学 温度応答性を有する生分解性ポリマー及びその製造方法
US8246998B2 (en) 2007-11-01 2012-08-21 Boston Scientific Scimed, Inc. Injectable biodegradable particles
CN102395401B (zh) 2009-02-12 2015-08-19 因赛普特有限责任公司 经由水凝胶塞的药物递送
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
SG10201508568VA (en) 2010-12-29 2015-11-27 Medincell Biodegradable drug delivery compositions
US20130195946A1 (en) * 2012-01-31 2013-08-01 Aurora Stamper Insecticidal hydrogel feeding spheres
JP6134788B2 (ja) 2012-06-27 2017-05-24 メドインセルル 疎水性組成物のための生分解性薬物送達
FR3027522B1 (fr) 2014-10-27 2016-12-09 I Ceram Composition poreuse chargee en principe actif
KR101694228B1 (ko) * 2014-10-29 2017-01-10 인하대학교 산학협력단 장기간 보관이 가능한 폴리디아세틸렌 기반의 바이오센서
AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
US11801217B2 (en) 2017-07-17 2023-10-31 Medincell S.A. Biodegradable block copolymer drug delivery composition
WO2019195256A1 (en) 2018-04-04 2019-10-10 Board Of Regents, The University Of Texas System Biodegradable elastic hydrogels for bioprinting
GB201900258D0 (en) 2019-01-08 2019-02-27 Medincell Pharmaceutical composition
EP4014963A1 (de) 2020-12-16 2022-06-22 Medincell Pharmazeutische zusammensetzung
GB202104224D0 (en) 2021-03-25 2021-05-12 Medincell Pharmaceutical composition
CN117222402A (zh) 2021-04-30 2023-12-12 美蒂森股份公司 新制剂
BR112024002231A2 (pt) 2021-08-05 2024-04-30 Medincell S A Composição farmacêutica

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
CA1043039A (en) * 1973-01-29 1978-11-21 Robert D. Lundberg Multiphase block and graft copolymers comprising a hydrophilic continuous phase and hydrophobic domains
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
JPH0678375B2 (ja) * 1985-12-09 1994-10-05 三井東圧化学株式会社 高分子多孔体の製造方法
US4882168A (en) * 1986-09-05 1989-11-21 American Cyanamid Company Polyesters containing alkylene oxide blocks as drug delivery systems
IL82834A (en) * 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5019094A (en) * 1990-05-09 1991-05-28 Ethicon, Inc. Crystalline copolymers of p-dioxanone and poly(alkylene oxides)
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof

Also Published As

Publication number Publication date
FR2741628B1 (fr) 1998-02-06
ES2159767T3 (es) 2001-10-16
DK0863933T3 (da) 2001-09-24
ATE202373T1 (de) 2001-07-15
PT863933E (pt) 2001-12-28
GR3036586T3 (en) 2001-12-31
DE69613481D1 (de) 2001-07-26
JP2000500803A (ja) 2000-01-25
WO1997019973A1 (fr) 1997-06-05
EP0863933B1 (de) 2001-06-20
US6350812B1 (en) 2002-02-26
FR2741628A1 (fr) 1997-05-30
JP4521067B2 (ja) 2010-08-11
EP0863933A1 (de) 1998-09-16
JP2008056935A (ja) 2008-03-13

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