JP2000500803A - トリブロック共重合体を基材とする新規なヒドロゲル、その製造及びその用途 - Google Patents
トリブロック共重合体を基材とする新規なヒドロゲル、その製造及びその用途Info
- Publication number
- JP2000500803A JP2000500803A JP9520237A JP52023797A JP2000500803A JP 2000500803 A JP2000500803 A JP 2000500803A JP 9520237 A JP9520237 A JP 9520237A JP 52023797 A JP52023797 A JP 52023797A JP 2000500803 A JP2000500803 A JP 2000500803A
- Authority
- JP
- Japan
- Prior art keywords
- hydrogel
- water
- copolymer
- hydrophobic
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/916—Hydrogel compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.トリブロック共重合体と水とを基材とするヒドロゲルであって、上記ヒド ロゲルは上記トリブロック共重合体の重量と少なくとも等しい量の水を含有する 軟質ヒドロゲルの形で提供されること及び上記共重合体は、式(I): X−G−Y (I) [式中、Gはp個の反復単位からなる非ヒドロキシル化親水性線状重合体ブロック であり、pは10から150まで変動し得る数であり、X及びYの各々は、それぞれ、 m個及びn個の反復単位からなるポリエステルブロックを表し、比(m+n)/pは上記 共重合体が水に不溶性であるのに十分な大きさでありかつ比(m+n)/pは上記共重 合体の水混和性有機溶剤中の溶液に水を添加することにより、上記共重合体の重 量と少なくとも等しい量の水を保持することのできる軟質ゲルが形成されるよう に選択される]で表されることを特徴とするヒドロゲル。 2.pは10から120まで、特に、15から100まで変動し得る数である、請求項1 に記載のヒドロゲル。 3.前記比(m+n)/pは、前記ヒドロゲルが該ゲル中に含有される共重合体の重 量と少なくとも等しい量〜その2倍の量の水を含有し得るように選択される、請 求項1又は2に記載のヒドロゲル。 4.前記比(m+n)/pは約1〜5の数である、請求項1〜3のいずれかに記載の ヒドロゲル。 5.X及びYが、(i)乳酸、グリコール酸、マレイン酸モノエステル、ラクチ ド、グリコシド又はパラ−ジオキサノンから選ばれた単量体から誘導される重合 体、(ii)これらの単量体相互により形成される共重合体又は(iii)ジアシッドと ジオールとの重縮合により得られる重合体を表す、請求項1〜4のいずれかに記 載のヒドロゲル。 6.Gによって表わされる重合体ブロックは下記のもの:ポリ(エチレングリ コール)、ポリ(ビニルピロリドン)及びポリアクリルアミドから選ばれる、請 求項1〜5のいずれかに記載のヒドロゲル。 7.疎水性物質を含有する、請求項1〜6のいずれかに記載のヒドロゲル。 8.疎水性物質は医薬、着色剤、芳香物質及び殺虫剤から選ばれる、請求項7 に記載のヒドロゲル。 9.疎水性物質はホルモン、抗生物質、駆虫薬、抗癌剤、麻酔剤、鎮静薬及び ペプチドから選ばれる、請求項7及び8に記載のヒドロゲル。 10.水溶性巨大分子を含有する、請求項1〜9のいずれかに記載のヒドロゲル 。 11.請求項1〜6のいずれかに記載のヒドロゲルの凍結乾燥により得られる凍 結乾燥物。 12.請求項7〜10のいずれかに記載のヒドロゲルの凍結乾燥により得られる凍 結乾燥物。 13.請求項1〜6のいずれかに記載のヒドロゲル又は請求項11に記載の凍結乾 燥物を基材として含有する組成物。 14.請求項7〜10のいずれかに記載のヒドロゲル又は請求項12に記載の凍結乾 燥物を含有する組成物。 15.請求項1〜7のいずれかに記載のヒドロゲル又は請求項11又は12に記載の 凍結乾燥物を含有する医薬組成物。 16.水溶性巨大分子からなる医薬を更に含有する、請求項15に記載の組成物。 17.2mmの内径を有する中空針又は1mmの内径を有する中空針を通過すること ができるのに十分な変形性を有する、請求項15又は16に記載の組成物。 18.請求項1〜6のいずれかに記載の共重合体X−G−Yの水混和性有機溶剤 中の溶液を調製しついでこの溶液を軟質ヒドロゲルを製造するのに十分な量の水 と接触させることを特徴とする、請求項1〜12のいずれかに記載のヒドロゲル又 は凍結乾燥物の製造方法。 19.ヒドロゲルの水による洗浄及び/又は水に対する透析及び/又は凍結乾燥を 更に行う、請求項18に記載の方法。 20.疎水性物質及び請求項1〜6のいずれかに記載のトリブロック共重合体を 、該疎水性物質及び共重合体に対する溶剤である水混和性有機溶剤中に 溶解させた溶液を調製しついでこの溶液を水と接触させて、上記疎水性物質を保 持することのできる軟質ヒドロゲルを得ることを特徴とする、疎水性物質をヒド ロゲル中に閉込める方法。 21.請求項1〜6のいずれかに記載のトリブロック共重合体を水混和性有機溶 剤中に溶解させた溶液を調製しついでこの溶液を疎水性巨大分子の水溶液と接触 させて、上記巨大分子を保持することのできる軟質ヒドロゲルを得ることを特徴 とする、疎水性巨大分子をヒドロゲル中に閉込める方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR95/14144 | 1995-11-29 | ||
FR9514144A FR2741628B1 (fr) | 1995-11-29 | 1995-11-29 | Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs |
PCT/FR1996/001901 WO1997019973A1 (fr) | 1995-11-29 | 1996-11-29 | Nouveaux hydrogels a base de copolymeres trisequences, leur preparation et leur application |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007248994A Division JP2008056935A (ja) | 1995-11-29 | 2007-09-26 | トリブロック共重合体を基材とする新規なヒドロゲル、その製造及びその用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000500803A true JP2000500803A (ja) | 2000-01-25 |
JP4521067B2 JP4521067B2 (ja) | 2010-08-11 |
Family
ID=9485003
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52023797A Expired - Fee Related JP4521067B2 (ja) | 1995-11-29 | 1996-11-29 | トリブロック共重合体を基材とする新規なヒドロゲル、その製造及びその用途 |
JP2007248994A Pending JP2008056935A (ja) | 1995-11-29 | 2007-09-26 | トリブロック共重合体を基材とする新規なヒドロゲル、その製造及びその用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007248994A Pending JP2008056935A (ja) | 1995-11-29 | 2007-09-26 | トリブロック共重合体を基材とする新規なヒドロゲル、その製造及びその用途 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6350812B1 (ja) |
EP (1) | EP0863933B1 (ja) |
JP (2) | JP4521067B2 (ja) |
AT (1) | ATE202373T1 (ja) |
DE (1) | DE69613481T2 (ja) |
DK (1) | DK0863933T3 (ja) |
ES (1) | ES2159767T3 (ja) |
FR (1) | FR2741628B1 (ja) |
GR (1) | GR3036586T3 (ja) |
PT (1) | PT863933E (ja) |
WO (1) | WO1997019973A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003523926A (ja) * | 1998-08-14 | 2003-08-12 | インセプト エルエルシー | 複合ヒドロゲル薬物送達システム |
WO2007119352A1 (ja) * | 2006-03-14 | 2007-10-25 | Jms.Co., Ltd | 生体吸収性材料製造用材料、生体吸収性材料およびそれらの製造方法 |
JP2008069324A (ja) * | 2006-09-15 | 2008-03-27 | Mitsui Chemicals Inc | 生分解性を有する水環境応答型ポリマーを含む水崩壊性組成物および水崩壊性成形体 |
JP2009029967A (ja) * | 2007-07-27 | 2009-02-12 | Univ Kansai | 温度応答性を有する生分解性ポリマー及びその製造方法 |
JP2009516532A (ja) * | 2005-10-11 | 2009-04-23 | サントル・ナショナル・ドゥ・ラ・レシェルシュ・サイエンティフィーク−セ・エン・エール・エス− | 組織の再構築のために特に有用な、生体適合性で且つ生分解性の多孔質マトリックス |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8003705B2 (en) | 1996-09-23 | 2011-08-23 | Incept Llc | Biocompatible hydrogels made with small molecule precursors |
US7009034B2 (en) | 1996-09-23 | 2006-03-07 | Incept, Llc | Biocompatible crosslinked polymers |
US6316522B1 (en) * | 1997-08-18 | 2001-11-13 | Scimed Life Systems, Inc. | Bioresorbable hydrogel compositions for implantable prostheses |
AU736812B2 (en) * | 1997-10-03 | 2001-08-02 | Btg International Limited | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6201072B1 (en) * | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6072101A (en) * | 1997-11-19 | 2000-06-06 | Amcol International Corporation | Multicomponent superabsorbent gel particles |
US6222091B1 (en) * | 1997-11-19 | 2001-04-24 | Basf Aktiengesellschaft | Multicomponent superabsorbent gel particles |
US7347850B2 (en) | 1998-08-14 | 2008-03-25 | Incept Llc | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof |
US6818018B1 (en) | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
WO2000033764A1 (en) | 1998-12-04 | 2000-06-15 | Pathak Chandrashekhar P | Biocompatible crosslinked polymers |
US7160931B2 (en) | 2000-03-15 | 2007-01-09 | Yu-Ling Cheng | Thermally reversible implant and filler |
CA2402546C (en) * | 2000-03-15 | 2009-06-02 | Yu-Ling Cheng | Environment responsive gelling copolymer |
US7193007B2 (en) | 2000-03-15 | 2007-03-20 | Yu-Ling Cheng | Environment responsive gelling copolymer |
US20040185101A1 (en) * | 2001-03-27 | 2004-09-23 | Macromed, Incorporated. | Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof |
US7347988B2 (en) * | 2001-11-15 | 2008-03-25 | University Of North Texas | Synthesis, uses and compositions of crystal hydrogels |
BR0305034A (pt) * | 2002-06-06 | 2004-07-20 | Nippon Catalytic Chem Ind | Composição para absorção de água, processo para produção da mesma, absorvente e produto absorvente |
WO2003104307A1 (en) * | 2002-06-10 | 2003-12-18 | Rhodia Inc | Phase-separated composition comprising two miscible solvents, and use thereof in a process for making capsules |
US7649023B2 (en) * | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
US20070054985A1 (en) * | 2003-06-10 | 2007-03-08 | Mathieu Joanicot | Phase-separated composition comprising two miscible solvents, and use thereof in a process for making capsules |
US20060018872A1 (en) * | 2004-06-16 | 2006-01-26 | Tew Gregory N | Poly(lactic acid) copolymer hydrogels and related methods of drug delivery |
US8357391B2 (en) * | 2004-07-30 | 2013-01-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages |
EP1922351A1 (en) * | 2005-09-07 | 2008-05-21 | DSMIP Assets B.V. | Polymers comprising thioester bonds |
FR2893943B1 (fr) * | 2005-11-28 | 2011-08-19 | Centre Nat Rech Scient | Procede de preparation de copolymeres par polymerisation anionique sans solvant |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
US8246998B2 (en) | 2007-11-01 | 2012-08-21 | Boston Scientific Scimed, Inc. | Injectable biodegradable particles |
US8409606B2 (en) | 2009-02-12 | 2013-04-02 | Incept, Llc | Drug delivery through hydrogel plugs |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
LT2658525T (lt) * | 2010-12-29 | 2017-12-11 | Medincell | Biologiškai skaidomos vaistų tiekimo kompozicijos |
US20130195946A1 (en) * | 2012-01-31 | 2013-08-01 | Aurora Stamper | Insecticidal hydrogel feeding spheres |
EP2866837B1 (en) * | 2012-06-27 | 2022-12-14 | Medincell S.A. | Biodegradable drug delivery for hydrophobic compositions |
FR3027522B1 (fr) | 2014-10-27 | 2016-12-09 | I Ceram | Composition poreuse chargee en principe actif |
KR101694228B1 (ko) * | 2014-10-29 | 2017-01-10 | 인하대학교 산학협력단 | 장기간 보관이 가능한 폴리디아세틸렌 기반의 바이오센서 |
HRP20231453T1 (hr) | 2015-11-16 | 2024-03-01 | Medincell S.A. | Postupak za morseliranje i/ili usmjeravanje farmaceutski aktivnih sastojaka na sinovijalno tkivo |
TWI795423B (zh) | 2017-07-17 | 2023-03-11 | 法商麥迪榭爾公司 | 用於調節至少一種活性成份之藥物釋放動力學的可生物降解之藥物傳遞之組合物混合物 |
US11884765B2 (en) | 2018-04-04 | 2024-01-30 | Board Of Regents, The University Of Texas System | Biodegradable elastic hydrogels for bioprinting |
GB201900258D0 (en) | 2019-01-08 | 2019-02-27 | Medincell | Pharmaceutical composition |
EP4014963A1 (en) | 2020-12-16 | 2022-06-22 | Medincell | Pharmaceutical composition |
GB202104224D0 (en) | 2021-03-25 | 2021-05-12 | Medincell | Pharmaceutical composition |
JP2024516264A (ja) | 2021-04-30 | 2024-04-12 | メディンセル エスアー | 新規製剤 |
BR112024002231A2 (pt) | 2021-08-05 | 2024-04-30 | Medincell S A | Composição farmacêutica |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1043039A (en) * | 1973-01-29 | 1978-11-21 | Robert D. Lundberg | Multiphase block and graft copolymers comprising a hydrophilic continuous phase and hydrophobic domains |
EP0092918B1 (en) * | 1982-04-22 | 1988-10-19 | Imperial Chemical Industries Plc | Continuous release formulations |
US4452973A (en) * | 1982-11-12 | 1984-06-05 | American Cyanamid Company | Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same |
JPH0678375B2 (ja) | 1985-12-09 | 1994-10-05 | 三井東圧化学株式会社 | 高分子多孔体の製造方法 |
US4882168A (en) * | 1986-09-05 | 1989-11-21 | American Cyanamid Company | Polyesters containing alkylene oxide blocks as drug delivery systems |
IL82834A (en) * | 1987-06-09 | 1990-11-05 | Yissum Res Dev Co | Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom |
US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5019094A (en) * | 1990-05-09 | 1991-05-28 | Ethicon, Inc. | Crystalline copolymers of p-dioxanone and poly(alkylene oxides) |
US5612052A (en) * | 1995-04-13 | 1997-03-18 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
-
1995
- 1995-11-29 FR FR9514144A patent/FR2741628B1/fr not_active Expired - Fee Related
-
1996
- 1996-11-29 JP JP52023797A patent/JP4521067B2/ja not_active Expired - Fee Related
- 1996-11-29 DK DK96941085T patent/DK0863933T3/da active
- 1996-11-29 AT AT96941085T patent/ATE202373T1/de active
- 1996-11-29 PT PT96941085T patent/PT863933E/pt unknown
- 1996-11-29 WO PCT/FR1996/001901 patent/WO1997019973A1/fr active IP Right Grant
- 1996-11-29 DE DE69613481T patent/DE69613481T2/de not_active Expired - Lifetime
- 1996-11-29 US US09/077,357 patent/US6350812B1/en not_active Expired - Fee Related
- 1996-11-29 EP EP96941085A patent/EP0863933B1/fr not_active Expired - Lifetime
- 1996-11-29 ES ES96941085T patent/ES2159767T3/es not_active Expired - Lifetime
-
2001
- 2001-09-11 GR GR20010401443T patent/GR3036586T3/el unknown
-
2007
- 2007-09-26 JP JP2007248994A patent/JP2008056935A/ja active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003523926A (ja) * | 1998-08-14 | 2003-08-12 | インセプト エルエルシー | 複合ヒドロゲル薬物送達システム |
JP2009516532A (ja) * | 2005-10-11 | 2009-04-23 | サントル・ナショナル・ドゥ・ラ・レシェルシュ・サイエンティフィーク−セ・エン・エール・エス− | 組織の再構築のために特に有用な、生体適合性で且つ生分解性の多孔質マトリックス |
WO2007119352A1 (ja) * | 2006-03-14 | 2007-10-25 | Jms.Co., Ltd | 生体吸収性材料製造用材料、生体吸収性材料およびそれらの製造方法 |
US8158729B2 (en) | 2006-03-14 | 2012-04-17 | Jms Co., Ltd. | Material for producing bioabsorbable material, bioabsorbable material, and process for producing these |
JP5267121B2 (ja) * | 2006-03-14 | 2013-08-21 | 株式会社ジェイ・エム・エス | 生体吸収性材料製造用材料、生体吸収性材料およびそれらの製造方法 |
JP2008069324A (ja) * | 2006-09-15 | 2008-03-27 | Mitsui Chemicals Inc | 生分解性を有する水環境応答型ポリマーを含む水崩壊性組成物および水崩壊性成形体 |
JP2009029967A (ja) * | 2007-07-27 | 2009-02-12 | Univ Kansai | 温度応答性を有する生分解性ポリマー及びその製造方法 |
Also Published As
Publication number | Publication date |
---|---|
EP0863933A1 (fr) | 1998-09-16 |
FR2741628A1 (fr) | 1997-05-30 |
DE69613481T2 (de) | 2002-04-25 |
FR2741628B1 (fr) | 1998-02-06 |
ES2159767T3 (es) | 2001-10-16 |
GR3036586T3 (en) | 2001-12-31 |
US6350812B1 (en) | 2002-02-26 |
WO1997019973A1 (fr) | 1997-06-05 |
JP4521067B2 (ja) | 2010-08-11 |
PT863933E (pt) | 2001-12-28 |
EP0863933B1 (fr) | 2001-06-20 |
JP2008056935A (ja) | 2008-03-13 |
DE69613481D1 (de) | 2001-07-26 |
DK0863933T3 (da) | 2001-09-24 |
ATE202373T1 (de) | 2001-07-15 |
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