DE69603968D1 - Verwendung von 1,4-dihydropyridinderivaten in der prävention und therapie der atherosklerotischen degeneration von arterienwänden - Google Patents

Verwendung von 1,4-dihydropyridinderivaten in der prävention und therapie der atherosklerotischen degeneration von arterienwänden

Info

Publication number
DE69603968D1
DE69603968D1 DE69603968T DE69603968T DE69603968D1 DE 69603968 D1 DE69603968 D1 DE 69603968D1 DE 69603968 T DE69603968 T DE 69603968T DE 69603968 T DE69603968 T DE 69603968T DE 69603968 D1 DE69603968 D1 DE 69603968D1
Authority
DE
Germany
Prior art keywords
arterial walls
therapy
prevention
lercanidipine
atherosclerotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69603968T
Other languages
English (en)
Other versions
DE69603968T2 (de
Inventor
Abraham Sartani
Amedeo Leonardi
Rodolfo Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati SA
Original Assignee
Recordati SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati SA filed Critical Recordati SA
Publication of DE69603968D1 publication Critical patent/DE69603968D1/de
Application granted granted Critical
Publication of DE69603968T2 publication Critical patent/DE69603968T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69603968T 1995-07-14 1996-06-28 Verwendung von 1,4-dihydropyridinderivaten in der prävention und therapie der atherosklerotischen degeneration von arterienwänden Expired - Fee Related DE69603968T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI951513A IT1275532B (it) 1995-07-14 1995-07-14 Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
PCT/EP1996/002872 WO1997003669A1 (en) 1995-07-14 1996-06-28 Use of 1,4-dihydropyridine derivatives in the prevention and therapy of atherosclerotic degradation of arterial walls

Publications (2)

Publication Number Publication Date
DE69603968D1 true DE69603968D1 (de) 1999-09-30
DE69603968T2 DE69603968T2 (de) 2000-04-06

Family

ID=11371972

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69603968T Expired - Fee Related DE69603968T2 (de) 1995-07-14 1996-06-28 Verwendung von 1,4-dihydropyridinderivaten in der prävention und therapie der atherosklerotischen degeneration von arterienwänden

Country Status (19)

Country Link
EP (1) EP0839036B1 (de)
JP (1) JPH11509214A (de)
KR (1) KR19990028741A (de)
CN (1) CN1190345A (de)
AT (1) ATE183644T1 (de)
AU (1) AU690471B2 (de)
CA (1) CA2219501A1 (de)
CZ (1) CZ11698A3 (de)
DE (1) DE69603968T2 (de)
DK (1) DK0839036T3 (de)
ES (1) ES2138359T3 (de)
GR (1) GR3031096T3 (de)
HU (1) HUP9802736A3 (de)
IL (1) IL122302A (de)
IT (1) IT1275532B (de)
NO (1) NO980171L (de)
SK (1) SK4198A3 (de)
WO (1) WO1997003669A1 (de)
ZA (1) ZA965924B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US6852737B2 (en) 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
TW200613275A (en) * 2004-08-24 2006-05-01 Recordati Ireland Ltd Lercanidipine salts
AR053023A1 (es) * 2005-02-25 2007-04-18 Recordati Ireland Ltd Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen
WO2011161223A2 (en) 2010-06-23 2011-12-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
MX2013004151A (es) 2010-10-12 2013-05-20 Medicines Co Formulaciones de emulsion de clevidipina que contienen agentes antimicrobianos.
SI2654729T1 (sl) 2010-12-24 2016-08-31 Krka, D.D., Novo Mesto Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters

Also Published As

Publication number Publication date
JPH11509214A (ja) 1999-08-17
ATE183644T1 (de) 1999-09-15
IL122302A (en) 2000-08-13
NO980171D0 (no) 1998-01-14
ITMI951513A1 (it) 1997-01-14
IL122302A0 (en) 1998-04-05
KR19990028741A (ko) 1999-04-15
SK4198A3 (en) 1998-05-06
GR3031096T3 (en) 1999-12-31
ES2138359T3 (es) 2000-01-01
EP0839036A1 (de) 1998-05-06
CN1190345A (zh) 1998-08-12
CA2219501A1 (en) 1997-02-06
WO1997003669A1 (en) 1997-02-06
ITMI951513A0 (it) 1995-07-14
HUP9802736A3 (en) 2000-03-28
IT1275532B (it) 1997-08-07
NO980171L (no) 1998-01-14
ZA965924B (en) 1997-01-30
HUP9802736A2 (hu) 1999-03-29
DE69603968T2 (de) 2000-04-06
EP0839036B1 (de) 1999-08-25
CZ11698A3 (cs) 1998-06-17
DK0839036T3 (da) 2000-01-24
AU6516496A (en) 1997-02-18
AU690471B2 (en) 1998-04-23

Similar Documents

Publication Publication Date Title
IS4536A (is) Ný taxóíð, aðferð til framleiðslu þeirra og lyfjasamsetningar sem innihalda þau
EE9700153A (et) Heterotsükliga kondenseerunud püridiinid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid
MC2077A1 (fr) Derives benzoiques et phenylacetiques,procedes pour leur preparation et compositions pharmaceutiques en contenant
NO975985L (no) Aromatiske forbindelser og farmasöytiske blandinger inneholdende dem
FI942076A (fi) Sappihappojohdannaisia, menetelmä niiden valmistamiseksi ja näiden yhdisteiden käyttö lääkaaineina
CY2008012I1 (el) Υδροξυεστερες ραπαμυκινης, διαδικασια για τη παρασκευη τους και φαρμακευτικες συνθεσεις περιεχουσες αυτες
IS1947B (is) Setin bensýlamínópíperidín efnasambönd og lyfjablöndur þeirra
AR017639A1 (es) Procedimiento de la alquilacion directa en una etapa, en las posiciones 7 y 10 simultaneamente de las dos funciones hidroxilos de la 10-desacetilbacatina o de los derivados de esta ultima esterificados en la posicion 13.
NO975984L (no) Aromatiske forbindelser og farmasöytiske blandinger inneholdende dem
DE69603968D1 (de) Verwendung von 1,4-dihydropyridinderivaten in der prävention und therapie der atherosklerotischen degeneration von arterienwänden
ATA900894A (de) Pharmazeutische kompositionen zum vorbeugen und heilen von krebserkrankungen und verfahren zu ihrer herstellung
FR2753449B1 (fr) Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique
DK0441279T3 (da) Bilobalid-phospholipid-komplekser, deres anvendelse og sammensætninger, der indeholder dem
DE69909128D1 (de) Einschlusskomplexe von dehydroepiandrosteron und korrespondierende pharmazeutische zusammenstellungen
ATE140455T1 (de) Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
FI953956A (fi) 2,3-rengaskondensoidut 1,4-dihydropyridiinit, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä
UA35566C2 (uk) Лікарський засіб для профілактики і лікування порушень ліпоїдного і холестеринового обміну речовин і спосіб профілактики і лікування цих порушень
KR900009580A (ko) 벤젠 유도체, 그 제조방법 및 그를 함유하는 약학 조성물
TW372962B (en) Pharmaceutical compositions for the prevention, arrest or reversal of atherosclerotic degradation in the arterial walls of a patient
DE69011046D1 (de) Pyridinderivate, Verfahren zur Herstellung und pharmazeutische Zusammensetzungen.
NO894594D0 (no) Farmasoeytiske sammensetninger omfattende labdan diterpenoid-derivater og pyrimido(6,1-a)isoquinolin-4-ono-derivater.
DE59200566D1 (de) Aryl-Chinolyl-substituierte 1,4-Dihydropyridin-dicarbonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln.
HUT60737A (en) Process for producing new 1,4-dihydropyridine derivatives and pharmaceutical compositions comprising same as active ingredient
FI972129A (fi) 6-metoksi-1H-bentsotriatsoli-5-karboksamidijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä lääkekoostumuksia
ATE157670T1 (de) Digitoxigenin und dihydrodigitoxigenin 3-beta- derivate und pharmazeutische präparate davon, zur behandlung von hypertonie

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: RECORDATI S. A. CHEMICAL AND PHARMACEUTICAL CO., C

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee