ES2138359T3 - Utilizacion de derivados de 1,4 dihidropiridina en la prevencion y la terapia de la degradacion arteroesclerosa de las paredes arteriales. - Google Patents

Utilizacion de derivados de 1,4 dihidropiridina en la prevencion y la terapia de la degradacion arteroesclerosa de las paredes arteriales.

Info

Publication number
ES2138359T3
ES2138359T3 ES96924834T ES96924834T ES2138359T3 ES 2138359 T3 ES2138359 T3 ES 2138359T3 ES 96924834 T ES96924834 T ES 96924834T ES 96924834 T ES96924834 T ES 96924834T ES 2138359 T3 ES2138359 T3 ES 2138359T3
Authority
ES
Spain
Prior art keywords
degradation
arterosclerous
dihydropyridine
therapy
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96924834T
Other languages
English (en)
Inventor
Abraham Sartani
Amedeo Leonardi
Rodolfo Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati SA
Original Assignee
Recordati SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati SA filed Critical Recordati SA
Application granted granted Critical
Publication of ES2138359T3 publication Critical patent/ES2138359T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE HA ENCONTRADO QUE LAS 1,4 - DIHIDROPIRIDINAS DETIENEN VARIOS PROCESOS QUE INTERVIENEN EN EL DESARROLLO DE LAS LESIONES VASCULARES ATEROSCLEROTICAS, COMO LA PROLIFERACION Y MIGRACION DE MIOCITOS, EL METABOLISMO DEL COLESTEROL EN LOS MACROFAGOS Y LA MODIFICACION OXIDATIVA DE LAS LIPOPROTEINAS DE BAJA DENSIDAD. POR TANTO, SON UTILES PARA LA FABRICACION DE MEDICAMENTOS QUE PREVENGAN, DETENGAN Y REVIERTAN LA DEGRADACION ATEROSCLEROTICA DE LAS PAREDES ARTERIALES HUMANAS. LAS 1,4 - DIHIDROPIRIDINAS PREFERENTES PARA ESTE PROPOSITO SON LERCANIDIPINO, (S) LERCANIDIPINO Y (R) - LERCANIDIPINO.
ES96924834T 1995-07-14 1996-06-28 Utilizacion de derivados de 1,4 dihidropiridina en la prevencion y la terapia de la degradacion arteroesclerosa de las paredes arteriales. Expired - Lifetime ES2138359T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI951513A IT1275532B (it) 1995-07-14 1995-07-14 Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa

Publications (1)

Publication Number Publication Date
ES2138359T3 true ES2138359T3 (es) 2000-01-01

Family

ID=11371972

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96924834T Expired - Lifetime ES2138359T3 (es) 1995-07-14 1996-06-28 Utilizacion de derivados de 1,4 dihidropiridina en la prevencion y la terapia de la degradacion arteroesclerosa de las paredes arteriales.

Country Status (19)

Country Link
EP (1) EP0839036B1 (es)
JP (1) JPH11509214A (es)
KR (1) KR19990028741A (es)
CN (1) CN1190345A (es)
AT (1) ATE183644T1 (es)
AU (1) AU690471B2 (es)
CA (1) CA2219501A1 (es)
CZ (1) CZ11698A3 (es)
DE (1) DE69603968T2 (es)
DK (1) DK0839036T3 (es)
ES (1) ES2138359T3 (es)
GR (1) GR3031096T3 (es)
HU (1) HUP9802736A3 (es)
IL (1) IL122302A (es)
IT (1) IT1275532B (es)
NO (1) NO980171L (es)
SK (1) SK4198A3 (es)
WO (1) WO1997003669A1 (es)
ZA (1) ZA965924B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US6852737B2 (en) 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
TW200613275A (en) * 2004-08-24 2006-05-01 Recordati Ireland Ltd Lercanidipine salts
AR053023A1 (es) * 2005-02-25 2007-04-18 Recordati Ireland Ltd Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen
WO2011161223A2 (en) 2010-06-23 2011-12-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
MX2013004151A (es) 2010-10-12 2013-05-20 Medicines Co Formulaciones de emulsion de clevidipina que contienen agentes antimicrobianos.
SI2654729T1 (sl) 2010-12-24 2016-08-31 Krka, D.D., Novo Mesto Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters

Also Published As

Publication number Publication date
JPH11509214A (ja) 1999-08-17
ATE183644T1 (de) 1999-09-15
DE69603968D1 (de) 1999-09-30
IL122302A (en) 2000-08-13
NO980171D0 (no) 1998-01-14
ITMI951513A1 (it) 1997-01-14
IL122302A0 (en) 1998-04-05
KR19990028741A (ko) 1999-04-15
SK4198A3 (en) 1998-05-06
GR3031096T3 (en) 1999-12-31
EP0839036A1 (en) 1998-05-06
CN1190345A (zh) 1998-08-12
CA2219501A1 (en) 1997-02-06
WO1997003669A1 (en) 1997-02-06
ITMI951513A0 (it) 1995-07-14
HUP9802736A3 (en) 2000-03-28
IT1275532B (it) 1997-08-07
NO980171L (no) 1998-01-14
ZA965924B (en) 1997-01-30
HUP9802736A2 (hu) 1999-03-29
DE69603968T2 (de) 2000-04-06
EP0839036B1 (en) 1999-08-25
CZ11698A3 (cs) 1998-06-17
DK0839036T3 (da) 2000-01-24
AU6516496A (en) 1997-02-18
AU690471B2 (en) 1998-04-23

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