DE69601865D1 - Photospaltung von rna mit texaphyrinen - Google Patents

Photospaltung von rna mit texaphyrinen

Info

Publication number
DE69601865D1
DE69601865D1 DE69601865T DE69601865T DE69601865D1 DE 69601865 D1 DE69601865 D1 DE 69601865D1 DE 69601865 T DE69601865 T DE 69601865T DE 69601865 T DE69601865 T DE 69601865T DE 69601865 D1 DE69601865 D1 DE 69601865D1
Authority
DE
Germany
Prior art keywords
texaphyrin
site
polymer
texaphyrines
ribonucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69601865T
Other languages
English (en)
Other versions
DE69601865T2 (de
Inventor
Darren Magda
Jonathan Sessler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacyclics LLC
University of Texas System
Original Assignee
Pharmacyclics LLC
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics LLC, University of Texas System filed Critical Pharmacyclics LLC
Application granted granted Critical
Publication of DE69601865D1 publication Critical patent/DE69601865D1/de
Publication of DE69601865T2 publication Critical patent/DE69601865T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69601865T 1995-06-07 1996-05-31 Photospaltung von rna mit texaphyrinen Expired - Fee Related DE69601865T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,551 US5714328A (en) 1995-06-07 1995-06-07 RNA photocleavage using texaphyrins
PCT/US1996/009419 WO1996040253A2 (en) 1995-06-07 1996-05-31 Rna photocleavage using texaphyrins

Publications (2)

Publication Number Publication Date
DE69601865D1 true DE69601865D1 (de) 1999-04-29
DE69601865T2 DE69601865T2 (de) 1999-08-05

Family

ID=23924628

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69601865T Expired - Fee Related DE69601865T2 (de) 1995-06-07 1996-05-31 Photospaltung von rna mit texaphyrinen

Country Status (14)

Country Link
US (1) US5714328A (de)
EP (1) EP0810878B1 (de)
JP (2) JPH10510844A (de)
KR (1) KR100355251B1 (de)
AT (1) ATE177951T1 (de)
AU (1) AU694051B2 (de)
CA (1) CA2218477C (de)
DE (1) DE69601865T2 (de)
DK (1) DK0810878T3 (de)
ES (1) ES2130826T3 (de)
GR (1) GR3030257T3 (de)
NO (1) NO975312L (de)
NZ (1) NZ310739A (de)
WO (1) WO1996040253A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457183A (en) * 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5969111A (en) * 1994-04-14 1999-10-19 Board Of Regents, The University Of Texas System Texaphyrins substituted with imidazole are provided
EP0864002A4 (de) 1995-10-27 1999-07-28 Elliot R Ramberg Verfahren und zusammensetzungen zur erkennung von spezifischen nukleotidsequenzen
US5776925A (en) * 1996-01-25 1998-07-07 Pharmacyclics, Inc. Methods for cancer chemosensitization
US6022959A (en) * 1996-08-20 2000-02-08 Pharmacyclics, Inc. Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof
AU5237798A (en) * 1997-05-14 1998-12-08 Sergy Mykolaiovytch Khrapunov Method for treatment of deoxyribonucleic acid sequence by restrictase
US6022526A (en) * 1997-07-30 2000-02-08 Pharmacyclics, Inc. Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanoma
US7049110B2 (en) * 1998-07-21 2006-05-23 Gambro, Inc. Inactivation of West Nile virus and malaria using photosensitizers
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US7498156B2 (en) * 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US6277337B1 (en) 1998-07-21 2001-08-21 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US20070099170A1 (en) * 1998-07-21 2007-05-03 Navigant Biotechnologies, Inc. Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
JP4207258B2 (ja) * 1998-08-31 2009-01-14 東ソー株式会社 特定核酸配列の切断方法
US6284220B1 (en) 1999-06-03 2001-09-04 The General Hospital Corporation Noninvasive imaging of nucleic acid vectors
US7220747B2 (en) * 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
US7985588B2 (en) * 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US7648699B2 (en) * 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
TW590780B (en) * 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US6843961B2 (en) * 2000-06-15 2005-01-18 Gambro, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US7112671B2 (en) * 2000-08-30 2006-09-26 Pharmacyclics, Inc. Non-symmetric tripyrranes in the synthesis of novel macrocycles
US6638924B2 (en) 2000-08-30 2003-10-28 Pharmacyclics, Inc. Metallotexaphyrin derivatives
US7449454B2 (en) * 2000-08-30 2008-11-11 Pharmacyclics, Inc. Metallotexaphyrin derivatives
EP1356086A2 (de) * 2000-12-13 2003-10-29 Institut Für Physikalische Hochtechnologie E.V. Verfahren zum simultanen positionsspezifischen schneiden von fadenförmigen organischen molekülketten, insbesonere dna
US20030228564A1 (en) * 2001-05-30 2003-12-11 Edrich Richard Alan Nitric oxide in a pathogen inactivation process
US6984734B2 (en) 2002-02-26 2006-01-10 Board Of Regents, The University Of Texas System Cyclo[n]pyrroles and methods thereto
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
JP2006224318A (ja) * 2005-02-15 2006-08-31 Brother Ind Ltd インクジェット記録装置
US20070072838A1 (en) 2005-09-26 2007-03-29 Pharmacyclics, Inc. High-purity texaphyrin metal complexes
US20070078119A1 (en) * 2005-09-30 2007-04-05 Pharmacyclics, Inc. Storage system for texaphyrin pharmaceutical formulations
US8133474B2 (en) * 2006-09-15 2012-03-13 Massachusetts Institute Of Technology Sensors for fluorescence and magnetic resonance imaging
US20140127077A1 (en) 2012-11-05 2014-05-08 Gail Rock Device and method for sterilization of instruments and surfaces

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318825A (en) * 1979-08-15 1982-03-09 Frame Robert R Catalytic composite, and method of manufacture
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4613322A (en) * 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
FR2540122B1 (fr) * 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
JPS61275228A (ja) * 1985-03-14 1986-12-05 バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド 治療用タンパク組成物中のビ−ルスの光動的不活性化
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
FR2586704B1 (fr) * 1985-09-04 1987-12-18 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs)
US4772681A (en) * 1986-01-17 1988-09-20 Hamari Chemicals, Ltd. Porphyrin derivatives
US5242797A (en) * 1986-03-21 1993-09-07 Myron J. Block Nucleic acid assay method
US4915683A (en) * 1986-11-21 1990-04-10 The Medical College Of Wisconsin, Inc. Antiviral method, agents and apparatus
US5135717A (en) * 1986-12-24 1992-08-04 British Technology Group Usa Inc. Tetrabenztriazaporphyrin reagents and kits containing the same
US4883790A (en) * 1987-01-20 1989-11-28 University Of British Columbia Wavelength-specific cytotoxic agents
US4878891A (en) * 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
JP2796153B2 (ja) * 1988-07-28 1998-09-10 ベスト インダストリーズ インコーポレーテッド 放射性材料収納カプセル
JPH04500516A (ja) * 1988-09-08 1992-01-30 ブリティッシュ　テクノロジー　グループ　ユーエスエイ，インコーポレイテッド 赤色シフト―フタロシアニン及びテトラベンゾトリアザポルフィリン試薬
US5272142A (en) * 1989-03-06 1993-12-21 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles and methods for treating tumors
US5256399A (en) * 1989-03-06 1993-10-26 Board Of Regents, The University Of Texas System Aromatic pentadentate expanded porphyrins in magnetic resonance imaging
US5162509A (en) * 1989-03-06 1992-11-10 Board Of Regents, The University Of Texas System Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US4935498A (en) * 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5041078A (en) * 1989-03-06 1991-08-20 Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas Photodynamic viral deactivation with sapphyrins
US5457183A (en) * 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5599923A (en) * 1989-03-06 1997-02-04 Board Of Regents, University Of Tx Texaphyrin metal complexes having improved functionalization
US5252720A (en) * 1989-03-06 1993-10-12 Board Of Regents, The University Of Texas System Metal complexes of water soluble texaphyrins
US5559207A (en) * 1989-03-06 1996-09-24 Board Of Regents, University Of Texas Texaphyrin metal complex mediated ester hydrolysis
US4959363A (en) * 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
FR2650761B1 (fr) * 1989-08-10 1994-03-04 Elf Aquitaine Ste Nale Catalyseur d'oxydation a base de metalloporphyrine sur support
US5219732A (en) * 1989-09-05 1993-06-15 The Regents Of The University Of California Antibody-mediated cofactor-driven reactions
US5159065A (en) * 1989-12-21 1992-10-27 Board Of Regents, The University Of Texas System Sapphyrins, derivatives and syntheses
US5457195A (en) * 1989-12-21 1995-10-10 Board Of Regents, The University Of Texas System Sapphyrin derivatives and conjugates
AU643542B2 (en) * 1990-06-14 1993-11-18 Monsanto Company RNA hydrolysis/cleavage
US5272056A (en) * 1991-01-03 1993-12-21 The Research Foundation Of State University Of New York Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
US5607924A (en) * 1992-01-21 1997-03-04 Pharmacyclics, Inc. DNA photocleavage using texaphyrins
US5371199B1 (en) * 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
FR2697254A1 (fr) * 1992-10-22 1994-04-29 Genset Sa Conjugués constitués par un oligonucléotide lié à des dérivés de métalloporphyrine cationique, leur préparation et leur utilisation.
EP0758250A1 (de) * 1994-04-28 1997-02-19 The Board Of Regents, The University Of Texas System Texaphyrin-festträger und vorrichtungen
EP0778845A1 (de) * 1994-09-02 1997-06-18 Novartis AG Oligonukleotidkonjugate, zusammensetzungen und verfahren zur spaltung von ribonukleinsäuren

Also Published As

Publication number Publication date
CA2218477C (en) 2002-10-22
GR3030257T3 (en) 1999-08-31
NZ310739A (en) 2000-09-29
AU6159096A (en) 1996-12-30
DE69601865T2 (de) 1999-08-05
US5714328A (en) 1998-02-03
EP0810878A2 (de) 1997-12-10
KR100355251B1 (ko) 2003-02-17
ATE177951T1 (de) 1999-04-15
KR19980701473A (ko) 1998-05-15
WO1996040253A3 (en) 1997-01-23
EP0810878B1 (de) 1999-03-24
JPH10510844A (ja) 1998-10-20
DK0810878T3 (da) 1999-10-11
NO975312L (no) 1998-02-05
JP2001316270A (ja) 2001-11-13
WO1996040253A2 (en) 1996-12-19
CA2218477A1 (en) 1996-12-19
ES2130826T3 (es) 1999-07-01
NO975312D0 (no) 1997-11-19
AU694051B2 (en) 1998-07-09

Similar Documents

Publication Publication Date Title
DE69601865D1 (de) Photospaltung von rna mit texaphyrinen
Peck-Miller et al. Kinetics of the processing of the precursor to 4· 5 S RNA, a naturally occurring substrate for RNase P from Escherichia coli
Knorre et al. Complementary-addressed (sequence-specific) modification of nucleic acids
Sancar et al. Repair of psoralen and acetylaminofluorene DNA adducts by ABC excinuclease
DE69736981D1 (de) In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
EP0967274A3 (de) Verfahren zur Reinigung von kovalent geschlossenen DNA-Molekülen
WO1994029316A3 (en) Texaphyrin metal complex mediated ester hydrolysis
Pratviel et al. Nonenzymic cleavage and ligation of DNA at a three A. cntdot. T base pair site. A two-step pseudohydrolysis of DNA
IL143238A0 (en) Dna-protein fusions and uses thereof
BR8805646A (pt) Processo para amplificacao de genes estaveis em adn cromossomico de microorganismos procarioticos
BR9306252A (pt) Processo para modificaçao enzimática de macromolécula biológica
Rabin et al. Analysis of RNA secondary structure by photochemical reversal of psoralen crosslinks
MXPA02002036A (es) Recombinacion especifica de la secuencia de adn en celulas eucarioticas.
Suzuki et al. Nucleotide sequence cleavages of manganese-bleomycin induced by reductant, hydrogen peroxide and ultraviolet light. Comparison with iron-and cobalt-bleomycins
WO2001091741A3 (en) Compositions containing hexitol and an antiproliferative agent
Bull et al. Inactivation of E. coli RNA polymerase by pyridoxal 5′-phosphate: Identification of a low pKa lysine as the modified residue
Holm et al. Similar cleavage efficiencies of an oligoribonucleotide substrate and an mdr1 mRNA segment by a hammerhead ribozyme
Ziemba et al. Repair of triplex-directed DNA alkylation by nucleotide excision repair
Watanabe et al. Specificity of nucleotide sequence in DNA cleavage induced by D-glucosamine and D-glucosamine-6-phosphate in the presence of Cu2+
Siddiqui et al. The Function of Pseudouridylic Acid in Transfer Ribonucleic Acid: IV. CYANOETHYLATION OF FRAGMENTS OF ESCHERICHIA COLI FORMYLMETHIONINE TRANSFER RIBONUCLEIC ACID AND RECONSTITUTION OF ACCEPTOR ACTIVITY
HK1030887A1 (en) Treatment of bladder cancer by mycobacterium phleicell wall.
AU4232597A (en) Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof
CY1107455T1 (el) Συνθεση και μεθοδος για την προκληση αποπτωσης σε καρκινικα κυτταρα του προστατη
Link et al. A hypothesis to explain the substrate reactivity of ribosomal and stem-loop RNA with ricin A-chain
AU5659696A (en) Nucleic acid molecule for treating b cell malignant tumor, p rocess for producing the same and utilization of the same

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee