WO1996040253A3 - Rna photocleavage using texaphyrins - Google Patents

Rna photocleavage using texaphyrins Download PDF

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Publication number
WO1996040253A3
WO1996040253A3 PCT/US1996/009419 US9609419W WO9640253A3 WO 1996040253 A3 WO1996040253 A3 WO 1996040253A3 US 9609419 W US9609419 W US 9609419W WO 9640253 A3 WO9640253 A3 WO 9640253A3
Authority
WO
WIPO (PCT)
Prior art keywords
texaphyrin
photocleavage
site
polymer
rna
Prior art date
Application number
PCT/US1996/009419
Other languages
French (fr)
Other versions
WO1996040253A2 (en
Inventor
Darren Magda
Jonathan L Sessler
Original Assignee
Pharmacyclics Inc
Univ Texas
Darren Magda
Jonathan L Sessler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Inc, Univ Texas, Darren Magda, Jonathan L Sessler filed Critical Pharmacyclics Inc
Priority to EP96919188A priority Critical patent/EP0810878B1/en
Priority to NZ310739A priority patent/NZ310739A/en
Priority to CA002218477A priority patent/CA2218477C/en
Priority to DK96919188T priority patent/DK0810878T3/en
Priority to JP9501740A priority patent/JPH10510844A/en
Priority to AU61590/96A priority patent/AU694051B2/en
Priority to DE69601865T priority patent/DE69601865T2/en
Publication of WO1996040253A2 publication Critical patent/WO1996040253A2/en
Publication of WO1996040253A3 publication Critical patent/WO1996040253A3/en
Priority to NO975312A priority patent/NO975312L/en
Priority to GR990401350T priority patent/GR3030257T3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods for photocleavage of a polymer of ribonucleic acid using a texaphyrin or a texaphyrin metal complex are provided. A preferred method of use is the site-specific cleavage of a polymer of ribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide. Possible substrates for cleavage include messenger, ribosomal, transfer, small nuclear, and small cytosolic ribonucleic acids, and RNA cofactors, thereby inactivating these ribonucleic acids and providing a multifaceted approach for treating benign or malignant cancer cells, or other undesired cells or tissues.
PCT/US1996/009419 1995-06-07 1996-05-31 Rna photocleavage using texaphyrins WO1996040253A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP96919188A EP0810878B1 (en) 1995-06-07 1996-05-31 Rna photocleavage using texaphyrins
NZ310739A NZ310739A (en) 1995-06-07 1996-05-31 RNA photocleavage using texaphyrins
CA002218477A CA2218477C (en) 1995-06-07 1996-05-31 Rna photocleavage using texaphyrins
DK96919188T DK0810878T3 (en) 1995-06-07 1996-05-31 RNA photo-cleavage using texaphyrins
JP9501740A JPH10510844A (en) 1995-06-07 1996-05-31 Photocleavage of RNA using texaphyrin
AU61590/96A AU694051B2 (en) 1995-06-07 1996-05-31 RNA photocleavage using texaphyrins
DE69601865T DE69601865T2 (en) 1995-06-07 1996-05-31 PHOTO CUTTING RNA WITH TEXAPHYRINES
NO975312A NO975312L (en) 1995-06-07 1997-11-19 RNA photo-cleavage using texaphyrins
GR990401350T GR3030257T3 (en) 1995-06-07 1999-05-19 Rna photocleavage using texaphyrins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,551 US5714328A (en) 1995-06-07 1995-06-07 RNA photocleavage using texaphyrins
US08/484,551 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040253A2 WO1996040253A2 (en) 1996-12-19
WO1996040253A3 true WO1996040253A3 (en) 1997-01-23

Family

ID=23924628

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009419 WO1996040253A2 (en) 1995-06-07 1996-05-31 Rna photocleavage using texaphyrins

Country Status (14)

Country Link
US (1) US5714328A (en)
EP (1) EP0810878B1 (en)
JP (2) JPH10510844A (en)
KR (1) KR100355251B1 (en)
AT (1) ATE177951T1 (en)
AU (1) AU694051B2 (en)
CA (1) CA2218477C (en)
DE (1) DE69601865T2 (en)
DK (1) DK0810878T3 (en)
ES (1) ES2130826T3 (en)
GR (1) GR3030257T3 (en)
NO (1) NO975312L (en)
NZ (1) NZ310739A (en)
WO (1) WO1996040253A2 (en)

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US20070099170A1 (en) * 1998-07-21 2007-05-03 Navigant Biotechnologies, Inc. Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US7498156B2 (en) * 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US6277337B1 (en) 1998-07-21 2001-08-21 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
JP4207258B2 (en) * 1998-08-31 2009-01-14 東ソー株式会社 Method for cleaving a specific nucleic acid sequence
US6284220B1 (en) 1999-06-03 2001-09-04 The General Hospital Corporation Noninvasive imaging of nucleic acid vectors
US7220747B2 (en) * 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
TW590780B (en) * 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US7648699B2 (en) * 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
US7985588B2 (en) * 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US6843961B2 (en) * 2000-06-15 2005-01-18 Gambro, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US7449454B2 (en) * 2000-08-30 2008-11-11 Pharmacyclics, Inc. Metallotexaphyrin derivatives
WO2002017925A1 (en) * 2000-08-30 2002-03-07 Pharmacyclics, Inc. Non-symmetric tripyrrannes in the synthesis of novel macrocycles
US6638924B2 (en) 2000-08-30 2003-10-28 Pharmacyclics, Inc. Metallotexaphyrin derivatives
WO2002048399A2 (en) * 2000-12-13 2002-06-20 Institut für Physikalische Hochtechnologie e.V. Method for the simultaneous dissection in specific positions of filiform organic molecular chains, in particular dna
US20030228564A1 (en) * 2001-05-30 2003-12-11 Edrich Richard Alan Nitric oxide in a pathogen inactivation process
US6984734B2 (en) 2002-02-26 2006-01-10 Board Of Regents, The University Of Texas System Cyclo[n]pyrroles and methods thereto
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
JP2006224318A (en) * 2005-02-15 2006-08-31 Brother Ind Ltd Inkjet recording apparatus
US20070072838A1 (en) 2005-09-26 2007-03-29 Pharmacyclics, Inc. High-purity texaphyrin metal complexes
US20070078119A1 (en) * 2005-09-30 2007-04-05 Pharmacyclics, Inc. Storage system for texaphyrin pharmaceutical formulations
US8133474B2 (en) * 2006-09-15 2012-03-13 Massachusetts Institute Of Technology Sensors for fluorescence and magnetic resonance imaging
US20140127077A1 (en) 2012-11-05 2014-05-08 Gail Rock Device and method for sterilization of instruments and surfaces

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Also Published As

Publication number Publication date
JPH10510844A (en) 1998-10-20
CA2218477C (en) 2002-10-22
ATE177951T1 (en) 1999-04-15
KR19980701473A (en) 1998-05-15
US5714328A (en) 1998-02-03
WO1996040253A2 (en) 1996-12-19
ES2130826T3 (en) 1999-07-01
KR100355251B1 (en) 2003-02-17
DE69601865D1 (en) 1999-04-29
DE69601865T2 (en) 1999-08-05
JP2001316270A (en) 2001-11-13
AU6159096A (en) 1996-12-30
GR3030257T3 (en) 1999-08-31
NZ310739A (en) 2000-09-29
EP0810878A2 (en) 1997-12-10
CA2218477A1 (en) 1996-12-19
AU694051B2 (en) 1998-07-09
NO975312L (en) 1998-02-05
NO975312D0 (en) 1997-11-19
EP0810878B1 (en) 1999-03-24
DK0810878T3 (en) 1999-10-11

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