DE69529499D1 - Stereoselektives Verfahren zur Herstellung von Dihydro-2,3-benzodiazepin-Derivaten - Google Patents
Stereoselektives Verfahren zur Herstellung von Dihydro-2,3-benzodiazepin-DerivatenInfo
- Publication number
- DE69529499D1 DE69529499D1 DE69529499T DE69529499T DE69529499D1 DE 69529499 D1 DE69529499 D1 DE 69529499D1 DE 69529499 T DE69529499 T DE 69529499T DE 69529499 T DE69529499 T DE 69529499T DE 69529499 D1 DE69529499 D1 DE 69529499D1
- Authority
- DE
- Germany
- Prior art keywords
- dihydro
- preparation
- benzodiazepine derivatives
- stereoselective process
- stereoselective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29864594A | 1994-08-31 | 1994-08-31 | |
US08/413,036 US5665878A (en) | 1994-08-31 | 1995-03-28 | Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69529499D1 true DE69529499D1 (de) | 2003-03-06 |
DE69529499T2 DE69529499T2 (de) | 2003-12-04 |
Family
ID=26970799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69529499T Expired - Lifetime DE69529499T2 (de) | 1994-08-31 | 1995-08-30 | Stereoselektives Verfahren zur Herstellung von Dihydro-2,3-benzodiazepin-Derivaten |
Country Status (22)
Country | Link |
---|---|
US (3) | US5919954A (de) |
EP (1) | EP0699677B1 (de) |
JP (1) | JP3481019B2 (de) |
KR (1) | KR100399518B1 (de) |
CN (1) | CN1086705C (de) |
AT (1) | ATE231867T1 (de) |
AU (1) | AU702658B2 (de) |
BR (1) | BR9503845A (de) |
CA (1) | CA2157234C (de) |
CZ (1) | CZ295675B6 (de) |
DE (1) | DE69529499T2 (de) |
DK (1) | DK0699677T3 (de) |
ES (1) | ES2189819T3 (de) |
FI (1) | FI113269B (de) |
HK (1) | HK1013818A1 (de) |
HU (1) | HU223776B1 (de) |
IL (1) | IL115100A (de) |
IN (1) | IN190402B (de) |
NO (1) | NO312838B1 (de) |
PL (3) | PL188796B1 (de) |
RU (1) | RU2151149C1 (de) |
TR (1) | TR199501071A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1271360A (zh) * | 1997-08-12 | 2000-10-25 | 埃吉斯药物工厂 | 作为ampa/红藻氨酸受体抑制剂的1,3-二氧杂环戊烷并/4,5-h//2,3/苯并-二氮杂䓬衍生物 |
UA67749C2 (uk) | 1997-08-12 | 2004-07-15 | Егіш Дьйодьсердьяр Рт. | Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування |
WO1999023242A1 (en) * | 1997-11-04 | 1999-05-14 | Eli Lilly And Company | Ketoreductase gene and protein from yeast |
US20030219456A1 (en) * | 2002-05-21 | 2003-11-27 | Taing Ok | Method of utilization of zygosaccharomyces rouxii |
US6858605B2 (en) | 2003-02-04 | 2005-02-22 | Ivax Drug Research Institute, Ltd. | Substituted 2,3-benzodiazepine derivatives |
ATE425817T1 (de) * | 2005-12-05 | 2009-04-15 | Deutsche Post Ag | Verfahren zum sortieren von postsendungen und vorrichtung mit einer datenstruktur fur einen sortierplan |
AU2006334172A1 (en) * | 2005-12-30 | 2007-07-12 | Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag | Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis |
KR100841592B1 (ko) | 2007-04-16 | 2008-06-26 | 한양대학교 산학협력단 | 벤조디옥솔 유도체와 이의 제조방법 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3794642A (en) * | 1973-01-15 | 1974-02-26 | Lilly Co Eli | Oxidation of substituted methanes to the corresponding substituted methanols |
DE2816475A1 (de) * | 1978-04-15 | 1979-10-25 | Bayer Ag | Isochroman-derivate, verfahren zu ihrer herstellung und ihre verwendung als synergisten in insektiziden und akariziden mitteln |
US4358041A (en) | 1980-06-12 | 1982-11-09 | Olin Corporation | Powder-actuated tool with power adjustment and angle-fire control |
HU191702B (en) * | 1984-06-27 | 1987-03-30 | Gyogyszerkutato Intezet | New process for preparing 1-aryl-5 h-2,3-benzodiazepines |
HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
HU198494B (en) | 1986-08-15 | 1989-10-30 | Gyogyszerkutato Intezet | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
EP0357787B1 (de) * | 1988-02-12 | 1996-05-08 | Daicel Chemical Industries, Ltd. | Verfahren zur herstellung von optisch aktiven 2-hydroxysäureabkömmlingen |
JP2679145B2 (ja) * | 1988-09-02 | 1997-11-19 | ダイセル化学工業株式会社 | オキシケトンの製造法 |
HU206719B (en) | 1990-12-21 | 1992-12-28 | Gyogyszerkutato Intezet | Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them |
HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
JP3061422B2 (ja) * | 1990-12-27 | 2000-07-10 | ダイセル化学工業株式会社 | 光学活性(s)−2−クロロ−1−フェニルプロパノールの製造法 |
JPH04271789A (ja) * | 1991-01-10 | 1992-09-28 | Takeda Chem Ind Ltd | D−パントラクトンの製造方法 |
HU219777B (hu) * | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
-
1995
- 1995-08-29 TR TR95/01071A patent/TR199501071A2/xx unknown
- 1995-08-30 CN CN95116311A patent/CN1086705C/zh not_active Expired - Fee Related
- 1995-08-30 HU HU9502545A patent/HU223776B1/hu not_active IP Right Cessation
- 1995-08-30 FI FI954064A patent/FI113269B/fi active
- 1995-08-30 DE DE69529499T patent/DE69529499T2/de not_active Expired - Lifetime
- 1995-08-30 NO NO19953396A patent/NO312838B1/no not_active IP Right Cessation
- 1995-08-30 EP EP95306051A patent/EP0699677B1/de not_active Expired - Lifetime
- 1995-08-30 JP JP22157095A patent/JP3481019B2/ja not_active Expired - Fee Related
- 1995-08-30 CZ CZ19952219A patent/CZ295675B6/cs not_active IP Right Cessation
- 1995-08-30 PL PL95310226A patent/PL188796B1/pl not_active IP Right Cessation
- 1995-08-30 BR BR9503845A patent/BR9503845A/pt not_active IP Right Cessation
- 1995-08-30 PL PL95369079A patent/PL190640B1/pl not_active IP Right Cessation
- 1995-08-30 RU RU95114549/04A patent/RU2151149C1/ru not_active IP Right Cessation
- 1995-08-30 AU AU30355/95A patent/AU702658B2/en not_active Ceased
- 1995-08-30 KR KR1019950027526A patent/KR100399518B1/ko not_active IP Right Cessation
- 1995-08-30 DK DK95306051T patent/DK0699677T3/da active
- 1995-08-30 AT AT95306051T patent/ATE231867T1/de not_active IP Right Cessation
- 1995-08-30 CA CA002157234A patent/CA2157234C/en not_active Expired - Fee Related
- 1995-08-30 PL PL95369080A patent/PL190318B1/pl not_active IP Right Cessation
- 1995-08-30 IL IL11510095A patent/IL115100A/xx not_active IP Right Cessation
- 1995-08-30 IN IN1044CA1995 patent/IN190402B/en unknown
- 1995-08-30 ES ES95306051T patent/ES2189819T3/es not_active Expired - Lifetime
-
1997
- 1997-04-14 US US08/843,307 patent/US5919954A/en not_active Expired - Fee Related
-
1998
- 1998-12-23 HK HK98115181A patent/HK1013818A1/xx not_active IP Right Cessation
-
1999
- 1999-03-02 US US09/260,449 patent/US5986114A/en not_active Expired - Fee Related
- 1999-07-02 US US09/346,795 patent/US6160133A/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT778277E (pt) | Derivados heterociclicos substituidos como antagonistas do crf | |
DE60040905D1 (de) | VERFAHREN ZUR HERSTELLUNG VON (E)-(6-i2-i4-(4-FLUORPHENYL)-6-ISOPROPYL-2-iMETHYL(METHYLSULFONYL)AMINO PYRIMIDIN-5-YL VINYL (4R,6S)-2,2-DIMETHYLi1,3 DIOXAN-4-YL)ESSIGSÄURE-TERT-BUTYLESTER | |
DE69231815D1 (de) | Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren | |
DE69529499T2 (de) | Stereoselektives Verfahren zur Herstellung von Dihydro-2,3-benzodiazepin-Derivaten | |
ATE51617T1 (de) | Verfahren zur herstellung von 4-phenyl-pyrrolderivaten. | |
DE69704832T2 (de) | Verfahren zur Herstellung von Pyrimidinderivaten | |
DE69925992D1 (de) | VERFAHREN ZUR HERSTELLUNG VON 5-HYDROXYBENZO[b]THIOPHEN-3-CARBONSÄURE | |
MY117754A (en) | Stereoselective process for producing dihydro-2, 3-benzodiazepine derivatives | |
MA23268A1 (fr) | Procede de preparation de composes azacyliques heterocycliques utiles comme antagonistes des recepteurs d'natagonisne ii. | |
AU3210593A (en) | Improvements in or relating to organic compounds | |
DE59812284D1 (de) | Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethyl-piperidin | |
DE59809538D1 (de) | Verfahren zur Herstellung von 1,2,3,6-Tetrahydro-2,2,6,6-tetramethylpyridin | |
DE59806309D1 (de) | Verfahren zur Herstellung von 1,2,3,6-Tetrahydro-2,2,6,6,-tetramethylpyridin-N-oxyl | |
ATE160147T1 (de) | Verfahren zur herstellung von enantiomer reinem imidazo (4,5,1-jk) (1,4)-benzodiazepin-2(1h)- thionen | |
DE69500362D1 (de) | Verfahren zur Herstellung 5,6-dihydroxyindol-Derivate ausgehend von Dopa | |
DE60006026D1 (de) | Verfahren zur Herstellung von 8-cyclopentyl-6-ethyl-3 (substituierten)-5,8-dihydro-4H-1,2,3A,7,8-penta aza-as-Indacenen und dafür geeigneter Zwischenprodukte | |
DE69816773D1 (de) | Verfahren zur herstellung von 1,4-benzodioxan-derivaten | |
DE59812729D1 (de) | Verfahren zur Herstellung von 1,3-Dioxanverbindungen | |
DK0949250T3 (da) | Fremgangsmåde til fremstilling af alpha1L-adrenoceptorantagonister | |
DE69834853D1 (de) | 1H-pyrrolo i1,2-böi1,2,4ötriazolederivate, Zwischenprodukte und Verfahren zur Herstellung von 1H-1,2,4,-triazol-5-yl Essigsäureesterderivate | |
DE3864463D1 (de) | Gamma-l-glutanyl-4-nitoanilid-derivate und verfahren zur bestimmung von gamma-gtp-aktivitaet unter verwendung dieser derivate. | |
DE3683352D1 (de) | Verfahren zur herstellung von indolinen. | |
BR9610392A (pt) | Processo para a preparação de derivados de rodanina substituídos com benzila | |
DE59709211D1 (de) | Verfahren zur Herstellung von 4,6-Dihydroxypyrimidin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |